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PubMed code 19914836

Compile data set for download or QSAR
Found 2 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
11-beta-hydroxysteroid dehydrogenase 1


(Rattus norvegicus (rat))
BDBM50233538
PNG
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
Show SMILES CC1(C)[C@@H](O)CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O |r,t:19|
Show InChI InChI=1S/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)/t19-,21-,22-,23+,26+,27-,28-,29+,30+/m0/s1
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Article
PubMed
n/an/a 90n/an/an/an/an/an/a



Vienna University of Technology

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in rat liver assessed as cortisone level


Bioorg Med Chem 18: 433-54 (2010)


Article DOI: 10.1016/j.bmc.2009.10.036
BindingDB Entry DOI: 10.7270/Q2BP02W3
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase type 2


(Rattus norvegicus)
BDBM50233538
PNG
(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
Show SMILES CC1(C)[C@@H](O)CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O |r,t:19|
Show InChI InChI=1S/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)/t19-,21-,22-,23+,26+,27-,28-,29+,30+/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 360n/an/an/an/an/an/a



Vienna University of Technology

Curated by ChEMBL


Assay Description
Inhibition of rat renal 11beta-HSD2 in rat liver assessed as inhibition of cortisone production


Bioorg Med Chem 18: 433-54 (2010)


Article DOI: 10.1016/j.bmc.2009.10.036
BindingDB Entry DOI: 10.7270/Q2BP02W3
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%