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PubMed code 1992112

Compile data set for download or QSAR
Found 53 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452955
PNG
(CHEMBL36271)
Show SMILES [I-].Cn1cc(-c2noc(C[N+](C)(C)C)n2)c2ccccc12
Show InChI InChI=1S/C15H19N4O.HI/c1-18-9-12(11-7-5-6-8-13(11)18)15-16-14(20-17-15)10-19(2,3)4;/h5-9H,10H2,1-4H3;1H/q+1;/p-1
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n/an/a 0.708n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50062446
PNG
(3-[3-(1-Methyl-1H-indol-3-yl)-[1,2,4]oxadiazol-5-y...)
Show SMILES Cn1cc(-c2noc(n2)C2CN3CCC2CC3)c2ccccc12 |TLB:7:9:13.12:15.16,(12.88,-12.88,;12.86,-11.36,;14.15,-10.61,;14.15,-9.1,;15.23,-8.03,;15.22,-6.52,;17.81,-6.52,;17.81,-8.01,;16.53,-8.78,;19.22,-8.8,;19.22,-10.41,;20.52,-11.16,;21.34,-9.77,;19.78,-9.35,;20.6,-7.97,;22.01,-8.78,;22.01,-10.39,;11.53,-9.11,;10.22,-8.34,;8.91,-9.11,;8.91,-10.63,;10.22,-11.4,;11.55,-10.63,)|
Show InChI InChI=1S/C18H20N4O/c1-21-10-15(13-4-2-3-5-16(13)21)17-19-18(23-20-17)14-11-22-8-6-12(14)7-9-22/h2-5,10,12,14H,6-9,11H2,1H3
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n/an/a 1.40n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM85330
PNG
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1ccccc1n2C
Show InChI InChI=1S/C18H19N3O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2/h3-6,9-10,13H,7-8,11H2,1-2H3
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n/an/a 1.90n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452961
PNG
(CHEMBL37802)
Show SMILES C1CN2CCC1C(C2)c1nc(no1)-c1c[nH]c2ccccc12 |(17.69,-11.42,;17.69,-12.94,;16.28,-13.67,;17.06,-12.36,;15.58,-11.97,;16.35,-10.64,;15.04,-11.43,;15.04,-12.97,;13.7,-10.67,;12.46,-11.42,;11.22,-10.7,;11.21,-9.26,;13.69,-9.25,;9.88,-11.45,;9.88,-12.98,;8.54,-13.73,;7.05,-13.34,;5.51,-14.18,;4,-13.29,;4.02,-11.52,;5.55,-10.67,;7.08,-11.57,)|
Show InChI InChI=1S/C17H18N4O/c1-2-4-15-12(3-1)13(9-18-15)16-19-17(22-20-16)14-10-21-7-5-11(14)6-8-21/h1-4,9,11,14,18H,5-8,10H2
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n/an/a 2.70n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452953
PNG
(CHEMBL284101)
Show SMILES Cn1cc(-c2noc(n2)C23CCN(CC2)CC3)c2ccccc12
Show InChI InChI=1S/C18H20N4O/c1-21-12-14(13-4-2-3-5-15(13)21)16-19-17(23-20-16)18-6-9-22(10-7-18)11-8-18/h2-5,12H,6-11H2,1H3
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n/an/a 4.30n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452944
PNG
(CHEMBL37444)
Show SMILES Cn1cc(-c2noc(n2)C2CN3CCC2C3)c2ccccc12 |THB:7:9:15:13.12|
Show InChI InChI=1S/C17H18N4O/c1-20-9-14(12-4-2-3-5-15(12)20)16-18-17(22-19-16)13-10-21-7-6-11(13)8-21/h2-5,9,11,13H,6-8,10H2,1H3
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n/an/a 7.59n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452944
PNG
(CHEMBL37444)
Show SMILES Cn1cc(-c2noc(n2)C2CN3CCC2C3)c2ccccc12 |THB:7:9:15:13.12|
Show InChI InChI=1S/C17H18N4O/c1-20-9-14(12-4-2-3-5-15(12)20)16-18-17(22-19-16)13-10-21-7-6-11(13)8-21/h2-5,9,11,13H,6-8,10H2,1H3
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n/an/a 7.60n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452966
PNG
(CHEMBL37500)
Show SMILES COc1cccc(c1)-c1noc(n1)C1CN2CCC1CC2 |(10.06,-7.99,;10.03,-9.49,;11.34,-10.27,;11.3,-11.8,;12.63,-12.57,;13.94,-11.81,;13.95,-10.32,;12.65,-9.52,;15.28,-9.56,;15.26,-8.06,;17.87,-8.04,;17.9,-9.55,;16.59,-10.32,;19.31,-10.35,;19.33,-11.96,;20.62,-12.71,;21.43,-11.33,;19.87,-10.9,;20.69,-9.52,;22.11,-10.32,;22.12,-11.94,)|
Show InChI InChI=1S/C16H19N3O2/c1-20-13-4-2-3-12(9-13)15-17-16(21-18-15)14-10-19-7-5-11(14)6-8-19/h2-4,9,11,14H,5-8,10H2,1H3
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n/an/a 13n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452959
PNG
(CHEMBL284523)
Show SMILES CN1CCC(CC1)c1nc(no1)-c1cn(C)c2ccccc12
Show InChI InChI=1S/C17H20N4O/c1-20-9-7-12(8-10-20)17-18-16(19-22-17)14-11-21(2)15-6-4-3-5-13(14)15/h3-6,11-12H,7-10H2,1-2H3
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Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452952
PNG
(CHEMBL36808)
Show SMILES CN1CCCC(C1)c1nc(no1)-c1cn(C)c2ccccc12
Show InChI InChI=1S/C17H20N4O/c1-20-9-5-6-12(10-20)17-18-16(19-22-17)14-11-21(2)15-8-4-3-7-13(14)15/h3-4,7-8,11-12H,5-6,9-10H2,1-2H3
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Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452963
PNG
(CHEMBL38310)
Show SMILES CN(C)CCc1nc(no1)-c1cn(C)c2ccccc12
Show InChI InChI=1S/C15H18N4O/c1-18(2)9-8-14-16-15(17-20-14)12-10-19(3)13-7-5-4-6-11(12)13/h4-7,10H,8-9H2,1-3H3
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n/an/a 14n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452958
PNG
(CHEMBL35722)
Show SMILES C1CN2CCC1C(C2)c1nc(no1)-c1[nH]nc2ccccc12 |(22.68,-8.88,;22.68,-10.42,;21.27,-11.14,;22.05,-9.84,;20.57,-9.44,;21.33,-8.13,;20.03,-8.91,;20.03,-10.43,;18.69,-8.15,;17.45,-8.88,;16.21,-8.16,;16.2,-6.74,;18.68,-6.72,;14.87,-8.92,;14.87,-10.46,;13.53,-11.19,;12.04,-10.81,;10.5,-11.67,;8.99,-10.78,;9.01,-8.99,;10.54,-8.15,;12.07,-9.05,)|
Show InChI InChI=1S/C16H17N5O/c1-2-4-13-11(3-1)14(19-18-13)15-17-16(22-20-15)12-9-21-7-5-10(12)6-8-21/h1-4,10,12H,5-9H2,(H,18,19)
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n/an/a 18n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452931
PNG
(CHEMBL35212)
Show SMILES Cn1cc(-c2nsc(n2)C2CC3CCN2C3)c2ccccc12 |THB:7:9:15:13.12|
Show InChI InChI=1S/C17H18N4S/c1-20-10-13(12-4-2-3-5-14(12)20)16-18-17(22-19-16)15-8-11-6-7-21(15)9-11/h2-5,10-11,15H,6-9H2,1H3
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n/an/a 20n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452931
PNG
(CHEMBL35212)
Show SMILES Cn1cc(-c2nsc(n2)C2CC3CCN2C3)c2ccccc12 |THB:7:9:15:13.12|
Show InChI InChI=1S/C17H18N4S/c1-20-10-13(12-4-2-3-5-14(12)20)16-18-17(22-19-16)15-8-11-6-7-21(15)9-11/h2-5,10-11,15H,6-9H2,1H3
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n/an/a 20.4n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM82561
PNG
(CAS_40796-97-2 | TROPANYL 3,5-DICHLOROBENZOATE | T...)
Show SMILES CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)c1cc(Cl)cc(Cl)c1 |r|
Show InChI InChI=1S/C15H17Cl2NO2/c1-18-12-2-3-13(18)8-14(7-12)20-15(19)9-4-10(16)6-11(17)5-9/h4-6,12-14H,2-3,7-8H2,1H3/t12-,13+,14+
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n/an/a 22n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452957
PNG
(CHEMBL34435)
Show SMILES C=CCn1cc(-c2noc(n2)C2CN3CCC2CC3)c2ccccc12 |(9.87,-17.73,;9.88,-16.09,;8.47,-15.27,;8.48,-13.63,;9.81,-12.88,;9.81,-11.37,;11.14,-10.62,;11.13,-9.2,;13.59,-9.18,;13.6,-10.6,;12.37,-11.33,;14.93,-11.35,;14.93,-12.87,;16.16,-13.57,;17.56,-12.85,;17.56,-11.33,;16.23,-10.56,;15.47,-11.88,;16.93,-12.27,;7.03,-11.48,;5.51,-10.6,;3.99,-11.44,;3.97,-13.19,;5.47,-14.08,;7,-13.25,)|
Show InChI InChI=1S/C20H22N4O/c1-2-9-24-13-17(15-5-3-4-6-18(15)24)19-21-20(25-22-19)16-12-23-10-7-14(16)8-11-23/h2-6,13-14,16H,1,7-12H2
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n/an/a 22n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for the displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor in rat brain membranes

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452954
PNG
(CHEMBL35775)
Show SMILES Cn1cc(-c2nc(no2)C2CN3CCC2CC3)c2ccccc12 |TLB:6:9:13.12:15.16,(12.88,-12.88,;12.86,-11.36,;14.15,-10.61,;14.15,-9.1,;15.23,-8.03,;16.53,-8.78,;17.81,-8.01,;17.81,-6.52,;15.22,-6.52,;19.22,-8.8,;19.22,-10.41,;20.52,-11.16,;21.34,-9.77,;19.78,-9.35,;20.6,-7.97,;22.01,-8.78,;22.01,-10.39,;11.53,-9.11,;10.22,-8.34,;8.91,-9.11,;8.91,-10.62,;10.22,-11.4,;11.55,-10.62,)|
Show InChI InChI=1S/C18H20N4O/c1-21-10-15(13-4-2-3-5-16(13)21)18-19-17(20-23-18)14-11-22-8-6-12(14)7-9-22/h2-5,10,12,14H,6-9,11H2,1H3
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n/an/a 30n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452969
PNG
(CHEMBL287685)
Show SMILES [I-].Cn1cc(-c2noc(n2)C2CCC[N+](C)(C)C2)c2ccccc12
Show InChI InChI=1S/C18H23N4O.HI/c1-21-11-15(14-8-4-5-9-16(14)21)17-19-18(23-20-17)13-7-6-10-22(2,3)12-13;/h4-5,8-9,11,13H,6-7,10,12H2,1-3H3;1H/q+1;/p-1
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n/an/a 35n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452932
PNG
(CHEMBL285166)
Show SMILES [I-].Cn1cc(-c2noc(n2)C2CC[N+](C)(C)CC2)c2ccccc12
Show InChI InChI=1S/C18H23N4O.HI/c1-21-12-15(14-6-4-5-7-16(14)21)17-19-18(23-20-17)13-8-10-22(2,3)11-9-13;/h4-7,12-13H,8-11H2,1-3H3;1H/q+1;/p-1
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n/an/a 35n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452967
PNG
(CHEMBL284315)
Show SMILES Oc1ccccc1-c1noc(n1)C1CN2CCC1CC2 |(12.68,-8.02,;12.65,-9.52,;11.34,-10.27,;11.3,-11.8,;12.63,-12.57,;13.94,-11.81,;13.95,-10.32,;15.28,-9.56,;15.26,-8.06,;17.87,-8.04,;17.9,-9.55,;16.59,-10.32,;19.31,-10.35,;19.33,-11.96,;20.62,-12.71,;21.43,-11.33,;19.87,-10.9,;20.69,-9.52,;22.11,-10.32,;22.12,-11.94,)|
Show InChI InChI=1S/C15H17N3O2/c19-13-4-2-1-3-11(13)14-16-15(20-17-14)12-9-18-7-5-10(12)6-8-18/h1-4,10,12,19H,5-9H2
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n/an/a 42n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452928
PNG
(CHEMBL288898)
Show SMILES Cn1cc(-c2noc(n2)C2CN3CCC2CC3)c2cc(F)ccc12 |(8.74,-15.25,;8.54,-13.73,;9.88,-12.98,;9.88,-11.45,;11.22,-10.7,;11.21,-9.26,;13.69,-9.25,;13.7,-10.67,;12.46,-11.42,;15.04,-11.43,;15.04,-12.97,;16.28,-13.67,;17.69,-12.94,;17.69,-11.42,;16.35,-10.64,;15.58,-11.97,;17.06,-12.36,;7.08,-11.57,;5.55,-10.67,;4.02,-11.52,;2.51,-10.6,;4,-13.29,;5.51,-14.18,;7.05,-13.34,)|
Show InChI InChI=1S/C18H19FN4O/c1-22-9-15(13-8-12(19)2-3-16(13)22)17-20-18(24-21-17)14-10-23-6-4-11(14)5-7-23/h2-3,8-9,11,14H,4-7,10H2,1H3
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n/an/a 46n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452972
PNG
(CHEMBL37237)
Show SMILES Cn1cc(-c2noc(CC3CN4CCC3CC4)n2)c2ccccc12 |(12.11,-13.55,;12.09,-12.04,;13.41,-11.27,;13.4,-9.74,;14.49,-8.65,;14.47,-7.12,;17.11,-7.12,;17.11,-8.64,;18.24,-9.77,;19.83,-9.33,;19.81,-7.7,;21.2,-6.87,;22.63,-7.66,;22.63,-9.26,;21.12,-10.08,;21.95,-8.68,;20.37,-8.27,;15.79,-9.42,;10.76,-9.74,;9.43,-8.98,;8.11,-9.76,;8.11,-11.29,;9.43,-12.05,;10.76,-11.27,)|
Show InChI InChI=1S/C19H22N4O/c1-22-12-16(15-4-2-3-5-17(15)22)19-20-18(24-21-19)10-14-11-23-8-6-13(14)7-9-23/h2-5,12-14H,6-11H2,1H3
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n/an/a 55n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452938
PNG
(CHEMBL288403)
Show SMILES C1CN2CCC1C(C2)c1nc(no1)-c1cccc2ccccc12 |(20.06,-11.01,;21.64,-11.44,;20.82,-12.83,;22.34,-12.06,;22.32,-10.42,;20.89,-9.62,;19.5,-10.45,;19.51,-12.07,;18.07,-9.64,;16.75,-10.42,;15.43,-9.65,;15.41,-8.14,;18.05,-8.11,;14.6,-11.18,;15.92,-11.96,;15.91,-13.49,;14.59,-14.23,;13.25,-13.47,;11.93,-14.2,;10.61,-13.43,;10.64,-11.89,;11.96,-11.14,;13.28,-11.93,)|
Show InChI InChI=1S/C19H19N3O/c1-2-6-15-13(4-1)5-3-7-16(15)18-20-19(23-21-18)17-12-22-10-8-14(17)9-11-22/h1-7,14,17H,8-12H2
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n/an/a 63n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452934
PNG
(CHEMBL286884)
Show SMILES Cn1cc(-c2noc(CCN)n2)c2ccccc12
Show InChI InChI=1S/C13H14N4O/c1-17-8-10(9-4-2-3-5-11(9)17)13-15-12(6-7-14)18-16-13/h2-5,8H,6-7,14H2,1H3
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n/an/a 68n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452965
PNG
(CHEMBL431892)
Show SMILES Oc1cccc(c1)-c1noc(n1)C1CN2CCC1CC2 |(3.45,-8.18,;4.75,-8.94,;4.71,-10.46,;6.04,-11.25,;7.34,-10.5,;7.35,-9,;6.05,-8.22,;8.68,-8.26,;8.65,-6.74,;11.26,-6.74,;11.28,-8.22,;9.98,-9.02,;12.69,-9.02,;12.71,-10.64,;13.99,-11.37,;14.8,-9.99,;13.25,-9.58,;14.07,-8.21,;15.48,-9.02,;15.49,-10.61,)|
Show InChI InChI=1S/C15H17N3O2/c19-12-3-1-2-11(8-12)14-16-15(20-17-14)13-9-18-6-4-10(13)5-7-18/h1-3,8,10,13,19H,4-7,9H2
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n/an/a 81n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452933
PNG
(CHEMBL37365)
Show SMILES CNCCc1nc(no1)-c1cn(C)c2ccccc12
Show InChI InChI=1S/C14H16N4O/c1-15-8-7-13-16-14(17-19-13)11-9-18(2)12-6-4-3-5-10(11)12/h3-6,9,15H,7-8H2,1-2H3
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n/an/a 85n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452945
PNG
(CHEMBL37360)
Show SMILES Cn1cc(-c2noc(n2)C2CC3CCC2NC3)c2ccccc12 |THB:7:9:15.16:13.12|
Show InChI InChI=1S/C18H20N4O/c1-22-10-14(12-4-2-3-5-16(12)22)17-20-18(23-21-17)13-8-11-6-7-15(13)19-9-11/h2-5,10-11,13,15,19H,6-9H2,1H3
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n/an/a 89n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452945
PNG
(CHEMBL37360)
Show SMILES Cn1cc(-c2noc(n2)C2CC3CCC2NC3)c2ccccc12 |THB:7:9:15.16:13.12|
Show InChI InChI=1S/C18H20N4O/c1-22-10-14(12-4-2-3-5-16(12)22)17-20-18(23-21-17)13-8-11-6-7-15(13)19-9-11/h2-5,10-11,13,15,19H,6-9H2,1H3
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n/an/a 89.1n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for the displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 recognition sites in rat brain membranes

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452937
PNG
(CHEMBL35645)
Show SMILES Cc1cccc2c(cn(C)c12)-c1noc(n1)C1CN2CCC1CC2 |(5.51,-15.83,;5.51,-14.18,;4,-13.28,;4.02,-11.52,;5.55,-10.67,;7.08,-11.56,;9.88,-11.45,;9.88,-12.97,;8.54,-13.73,;8.53,-15.38,;7.05,-13.34,;11.22,-10.69,;11.21,-9.26,;13.68,-9.25,;13.69,-10.67,;12.46,-11.41,;15.04,-11.43,;15.04,-12.96,;16.27,-13.66,;17.05,-12.35,;15.57,-11.96,;16.34,-10.63,;17.68,-11.41,;17.68,-12.94,)|
Show InChI InChI=1S/C19H22N4O/c1-12-4-3-5-14-16(10-22(2)17(12)14)18-20-19(24-21-18)15-11-23-8-6-13(15)7-9-23/h3-5,10,13,15H,6-9,11H2,1-2H3
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n/an/a 95n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452949
PNG
(CHEMBL36703)
Show SMILES Cn1cc(-c2noc(n2)C2CC3CCN2CC3)c2ccccc12 |TLB:7:9:13.12:15.16,(13.04,-13.04,;13.03,-11.51,;14.33,-10.75,;14.33,-9.22,;15.42,-8.13,;15.41,-6.6,;18.04,-6.6,;18.04,-8.11,;16.73,-8.89,;19.47,-8.91,;19.47,-10.54,;20.78,-11.3,;21.61,-9.9,;20.03,-9.47,;20.86,-8.07,;22.29,-8.89,;22.29,-10.52,;11.68,-9.23,;10.35,-8.45,;9.02,-9.23,;9.02,-10.76,;10.35,-11.54,;11.7,-10.76,)|
Show InChI InChI=1S/C18H20N4O/c1-21-11-14(13-4-2-3-5-15(13)21)17-19-18(23-20-17)16-10-12-6-8-22(16)9-7-12/h2-5,11-12,16H,6-10H2,1H3
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n/an/a 129n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452940
PNG
(CHEMBL36940)
Show SMILES Oc1ccc(cc1)-c1noc(n1)C1CN2CCC1CC2 |(10,-12.54,;11.3,-11.8,;12.63,-12.57,;13.94,-11.81,;13.95,-10.32,;12.65,-9.52,;11.34,-10.27,;15.28,-9.56,;15.26,-8.06,;17.87,-8.04,;17.9,-9.55,;16.59,-10.32,;19.31,-10.35,;19.33,-11.96,;20.62,-12.71,;22.12,-11.94,;22.11,-10.32,;20.69,-9.52,;19.87,-10.9,;21.43,-11.33,)|
Show InChI InChI=1S/C15H17N3O2/c19-12-3-1-11(2-4-12)14-16-15(20-17-14)13-9-18-7-5-10(13)6-8-18/h1-4,10,13,19H,5-9H2
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n/an/a 148n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452971
PNG
(CHEMBL37890)
Show SMILES COc1ccccc1-c1noc(n1)C1CN2CCC1CC2 |(13.99,-7.27,;12.68,-8.02,;12.65,-9.52,;11.34,-10.27,;11.3,-11.8,;12.63,-12.57,;13.94,-11.81,;13.95,-10.32,;15.28,-9.56,;15.26,-8.06,;17.87,-8.04,;17.9,-9.55,;16.59,-10.32,;19.31,-10.35,;19.33,-11.96,;20.62,-12.71,;21.43,-11.33,;19.87,-10.9,;20.69,-9.52,;22.11,-10.32,;22.12,-11.94,)|
Show InChI InChI=1S/C16H19N3O2/c1-20-14-5-3-2-4-12(14)15-17-16(21-18-15)13-10-19-8-6-11(13)7-9-19/h2-5,11,13H,6-10H2,1H3
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n/an/a 155n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452951
PNG
(CHEMBL288490)
Show SMILES CN(C)Cc1nc(no1)-c1cn(C)c2ccccc12
Show InChI InChI=1S/C14H16N4O/c1-17(2)9-13-15-14(16-19-13)11-8-18(3)12-7-5-4-6-10(11)12/h4-8H,9H2,1-3H3
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n/an/a 166n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452956
PNG
(CHEMBL35599)
Show SMILES CN(C)CCCc1nc(no1)-c1cn(C)c2ccccc12
Show InChI InChI=1S/C16H20N4O/c1-19(2)10-6-9-15-17-16(18-21-15)13-11-20(3)14-8-5-4-7-12(13)14/h4-5,7-8,11H,6,9-10H2,1-3H3
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n/an/a 191n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452970
PNG
(CHEMBL36478)
Show SMILES CN1C2CCC1CC(C2)c1nc(no1)-c1cn(C)c2ccccc12 |THB:0:1:7.6.8:3.4,9:7:1:3.4|
Show InChI InChI=1S/C19H22N4O/c1-22-11-16(15-5-3-4-6-17(15)22)18-20-19(24-21-18)12-9-13-7-8-14(10-12)23(13)2/h3-6,11-14H,7-10H2,1-2H3
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n/an/a 191n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452964
PNG
(CHEMBL37309)
Show SMILES C1CN2CCC1C(C2)c1nc(no1)-c1ccccc1 |(24.07,-9.43,;24.07,-11.06,;22.57,-11.83,;23.4,-10.44,;21.83,-10.01,;22.64,-8.63,;21.26,-9.45,;21.26,-11.07,;19.83,-8.65,;18.52,-9.43,;17.2,-8.66,;17.19,-7.15,;19.82,-7.13,;15.88,-9.43,;15.85,-10.93,;14.54,-11.69,;13.21,-10.91,;13.23,-9.38,;14.56,-8.63,)|
Show InChI InChI=1S/C15H17N3O/c1-2-4-12(5-3-1)14-16-15(19-17-14)13-10-18-8-6-11(13)7-9-18/h1-5,11,13H,6-10H2
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Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452943
PNG
(CHEMBL413273)
Show SMILES CN1CCC=C(C1)c1nc(no1)-c1cn(C)c2ccccc12 |c:4|
Show InChI InChI=1S/C17H18N4O/c1-20-9-5-6-12(10-20)17-18-16(19-22-17)14-11-21(2)15-8-4-3-7-13(14)15/h3-4,6-8,11H,5,9-10H2,1-2H3
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n/an/a 209n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for the displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor in rat brain membranes

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452929
PNG
(CHEMBL287093)
Show SMILES CN1CC2CCC1C(C2)c1nc(no1)-c1cn(C)c2ccccc12 |TLB:9:7:1.2:5.4,THB:0:1:7.8:5.4|
Show InChI InChI=1S/C19H22N4O/c1-22-10-12-7-8-17(22)14(9-12)19-20-18(21-24-19)15-11-23(2)16-6-4-3-5-13(15)16/h3-6,11-12,14,17H,7-10H2,1-2H3
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n/an/a 223n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452929
PNG
(CHEMBL287093)
Show SMILES CN1CC2CCC1C(C2)c1nc(no1)-c1cn(C)c2ccccc12 |TLB:9:7:1.2:5.4,THB:0:1:7.8:5.4|
Show InChI InChI=1S/C19H22N4O/c1-22-10-12-7-8-17(22)14(9-12)19-20-18(21-24-19)15-11-23(2)16-6-4-3-5-13(15)16/h3-6,11-12,14,17H,7-10H2,1-2H3
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n/an/a 224n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452942
PNG
(CHEMBL36315)
Show SMILES Cn1cc(-c2noc(CN)n2)c2ccccc12
Show InChI InChI=1S/C12H12N4O/c1-16-7-9(8-4-2-3-5-10(8)16)12-14-11(6-13)17-15-12/h2-5,7H,6,13H2,1H3
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n/an/a 282n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452960
PNG
(CHEMBL286001)
Show SMILES Cc1ccc2n(C)cc(-c3noc(n3)C3CN4CCC3CC4)c2c1 |(2.61,-10.67,;4.02,-11.52,;4,-13.28,;5.51,-14.18,;7.05,-13.34,;8.54,-13.73,;8.53,-15.38,;9.88,-12.97,;9.88,-11.45,;11.22,-10.69,;11.21,-9.26,;13.68,-9.25,;13.69,-10.67,;12.46,-11.41,;15.04,-11.43,;15.04,-12.96,;16.27,-13.66,;17.68,-12.94,;17.68,-11.41,;16.34,-10.63,;15.57,-11.96,;17.05,-12.35,;7.08,-11.56,;5.55,-10.67,)|
Show InChI InChI=1S/C19H22N4O/c1-12-3-4-17-14(9-12)16(10-22(17)2)18-20-19(24-21-18)15-11-23-7-5-13(15)6-8-23/h3-4,9-10,13,15H,5-8,11H2,1-2H3
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n/an/a 331n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452941
PNG
(CHEMBL36601)
Show SMILES Cn1cc(-c2noc(CCN3CCCCC3)n2)c2ccccc12
Show InChI InChI=1S/C18H22N4O/c1-21-13-15(14-7-3-4-8-16(14)21)18-19-17(23-20-18)9-12-22-10-5-2-6-11-22/h3-4,7-8,13H,2,5-6,9-12H2,1H3
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n/an/a 372n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452936
PNG
(CHEMBL36330)
Show SMILES Cn1cc(-c2noc(n2)C2=CCCNC2)c2ccccc12 |t:10|
Show InChI InChI=1S/C16H16N4O/c1-20-10-13(12-6-2-3-7-14(12)20)15-18-16(21-19-15)11-5-4-8-17-9-11/h2-3,5-7,10,17H,4,8-9H2,1H3
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Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452962
PNG
(CHEMBL37359)
Show SMILES CN1CCC(=CC1)c1nnc(o1)-c1cn(C)c2ccccc12 |c:4|
Show InChI InChI=1S/C17H18N4O/c1-20-9-7-12(8-10-20)16-18-19-17(22-16)14-11-21(2)15-6-4-3-5-13(14)15/h3-7,11H,8-10H2,1-2H3
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Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50014406
PNG
(2-Me 5-HT | 2-Methyl-5-hydroxytryptamine | 2-methy...)
Show SMILES Cc1[nH]c2ccc(O)cc2c1CCN
Show InChI InChI=1S/C11H14N2O/c1-7-9(4-5-12)10-6-8(14)2-3-11(10)13-7/h2-3,6,13-14H,4-5,12H2,1H3
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n/an/a 646n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452947
PNG
(CHEMBL36204)
Show SMILES Cn1c(cc2ccccc12)-c1noc(n1)C1CN2CCC1CC2 |(12.88,-9.99,;12.9,-8.35,;14.24,-7.6,;14.24,-6.07,;11.44,-6.19,;9.94,-5.28,;8.4,-6.14,;8.38,-7.91,;9.9,-8.79,;11.41,-7.95,;16.08,-8.22,;16.06,-6.79,;18.53,-6.79,;18.55,-8.21,;17.32,-8.94,;19.88,-8.94,;19.89,-10.48,;21.11,-11.19,;21.88,-9.87,;20.41,-9.49,;21.18,-8.18,;22.52,-8.94,;22.53,-10.45,)|
Show InChI InChI=1S/C18H20N4O/c1-21-15-5-3-2-4-13(15)10-16(21)17-19-18(23-20-17)14-11-22-8-6-12(14)7-9-22/h2-5,10,12,14H,6-9,11H2,1H3
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n/an/a 676n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452939
PNG
(CHEMBL287006)
Show SMILES C1CN2CCC1C(C2)c1nc(no1)-c1cc2ccccc2[nH]1 |(20.57,-9.44,;22.05,-9.84,;21.27,-11.14,;22.68,-10.42,;22.68,-8.88,;21.33,-8.13,;20.03,-8.91,;20.03,-10.43,;18.69,-8.15,;17.45,-8.88,;16.21,-8.16,;16.2,-6.74,;18.68,-6.72,;14.53,-7.61,;14.53,-6.09,;11.73,-6.2,;10.19,-5.31,;8.67,-6.16,;8.64,-7.92,;10.16,-8.82,;11.69,-7.98,;13.18,-8.37,)|
Show InChI InChI=1S/C17H18N4O/c1-2-4-14-12(3-1)9-15(18-14)16-19-17(22-20-16)13-10-21-7-5-11(13)6-8-21/h1-4,9,11,13,18H,5-8,10H2
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n/an/a 692n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452950
PNG
(CHEMBL288489)
Show SMILES CNCc1nc(no1)-c1cn(C)c2ccccc12
Show InChI InChI=1S/C13H14N4O/c1-14-7-12-15-13(16-18-12)10-8-17(2)11-6-4-3-5-9(10)11/h3-6,8,14H,7H2,1-2H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452935
PNG
(CHEMBL37093)
Show SMILES C1CN2CCC1C(C2)c1nc(no1)-c1ccc2ccccc2c1 |(19.98,-10.96,;21.55,-11.39,;20.73,-12.78,;22.24,-12.01,;22.23,-10.38,;20.81,-9.58,;19.42,-10.4,;19.43,-12.02,;18,-9.6,;16.68,-10.38,;15.37,-9.61,;15.34,-8.1,;17.97,-8.08,;14.03,-10.38,;14.02,-11.88,;12.7,-12.64,;11.36,-11.86,;10.05,-12.61,;8.74,-11.83,;8.77,-10.29,;10.09,-9.54,;11.4,-10.33,;12.71,-9.58,)|
Show InChI InChI=1S/C19H19N3O/c1-2-4-15-11-16(6-5-13(15)3-1)18-20-19(23-21-18)17-12-22-9-7-14(17)8-10-22/h1-6,11,14,17H,7-10,12H2
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n/an/a 1.48E+3n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452946
PNG
(CHEMBL36854)
Show SMILES C1CN2CCC1C(C2)c1nc(no1)-c1cnc2ccccc2c1 |(21.29,-10.96,;22.86,-11.39,;22.05,-12.78,;23.56,-12.01,;23.54,-10.38,;22.12,-9.58,;20.73,-10.4,;20.75,-12.02,;19.31,-9.6,;18,-10.38,;16.68,-9.61,;16.66,-8.1,;19.29,-8.08,;15.34,-10.38,;15.33,-11.88,;14.02,-12.64,;12.68,-11.86,;11.36,-12.61,;10.05,-11.83,;10.09,-10.29,;11.4,-9.54,;12.71,-10.33,;14.03,-9.58,)|
Show InChI InChI=1S/C18H18N4O/c1-2-4-16-13(3-1)9-14(10-19-16)17-20-18(23-21-17)15-11-22-7-5-12(15)6-8-22/h1-4,9-10,12,15H,5-8,11H2
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n/an/a 1.51E+3n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452968
PNG
(CHEMBL37922)
Show SMILES COc1ccc(cc1)-c1noc(n1)C1CN2CCC1CC2 |(11.29,-14.41,;10.54,-13.08,;11.3,-11.8,;12.63,-12.57,;13.94,-11.81,;13.95,-10.32,;12.65,-9.52,;11.34,-10.27,;15.28,-9.56,;15.26,-8.06,;17.87,-8.04,;17.9,-9.55,;16.59,-10.32,;19.31,-10.35,;19.33,-11.96,;20.62,-12.71,;22.12,-11.94,;22.11,-10.32,;20.69,-9.52,;19.87,-10.9,;21.43,-11.33,)|
Show InChI InChI=1S/C16H19N3O2/c1-20-13-4-2-12(3-5-13)15-17-16(21-18-15)14-10-19-8-6-11(14)7-9-19/h2-5,11,14H,6-10H2,1H3
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n/an/a 1.59E+3n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452930
PNG
(CHEMBL37797)
Show SMILES C1CN2CCC1C(C2)c1nc(no1)-c1cccnc1 |(20.89,-9.58,;22.4,-9.99,;21.6,-11.32,;23.04,-10.59,;23.04,-9.03,;21.67,-8.26,;20.35,-9.05,;20.35,-10.6,;18.98,-8.28,;17.73,-9.03,;16.47,-8.29,;16.46,-6.85,;18.97,-6.82,;15.2,-9.03,;13.94,-8.26,;12.66,-8.98,;12.65,-10.45,;13.92,-11.19,;15.17,-10.46,)|
Show InChI InChI=1S/C14H16N4O/c1-2-11(8-15-5-1)13-16-14(19-17-13)12-9-18-6-3-10(12)4-7-18/h1-2,5,8,10,12H,3-4,6-7,9H2
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n/an/a 2.95E+3n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452948
PNG
(CHEMBL36093)
Show SMILES CN1CCC=C(C1)c1csc(n1)-c1cn(C)c2ccccc12 |c:4|
Show InChI InChI=1S/C18H19N3S/c1-20-9-5-6-13(10-20)16-12-22-18(19-16)15-11-21(2)17-8-4-3-7-14(15)17/h3-4,6-8,11-12H,5,9-10H2,1-2H3
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n/an/a 5.89E+3n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%