Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dihydrofolate reductase (Homo sapiens (Human)) | BDBM18050 (2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank MMDB PDB PubMed | n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Alabama Curated by ChEMBL | Assay Description Compound was tested for its inhibitory activity on Recombinant Human Dihydrofolate Reductase. | J Med Chem 34: 222-7 (1991) BindingDB Entry DOI: 10.7270/Q2XD10N1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Dihydrofolate reductase (Homo sapiens (Human)) | BDBM50010932 ((10-DA, 10-Deazaminopterin)2-{4-[2-(2,4-Diamino-pt...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Alabama Curated by ChEMBL | Assay Description Compound was tested for its inhibitory activity on Recombinant Human Dihydrofolate Reductase. | J Med Chem 34: 222-7 (1991) BindingDB Entry DOI: 10.7270/Q2XD10N1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Homo sapiens (Human)) | BDBM50016460 ((S)-2-{4-[1-(2,4-Diamino-pteridin-6-ylmethyl)-prop...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Alabama Curated by ChEMBL | Assay Description Compound was tested for its inhibitory activity on Recombinant Human Dihydrofolate Reductase. | J Med Chem 34: 222-7 (1991) BindingDB Entry DOI: 10.7270/Q2XD10N1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Homo sapiens (Human)) | BDBM50010930 (2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-ami...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 5.30 | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Alabama Curated by ChEMBL | Assay Description Compound was tested for its inhibitory activity on Recombinant Human Dihydrofolate Reductase. | J Med Chem 34: 222-7 (1991) BindingDB Entry DOI: 10.7270/Q2XD10N1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Homo sapiens (Human)) | BDBM50010928 (2-{4-[1-(2,4-Diamino-pteridin-6-ylmethyl)-propyl]-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 5.80 | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Alabama Curated by ChEMBL | Assay Description Compound was tested for its inhibitory activity on Recombinant Human Dihydrofolate Reductase. | J Med Chem 34: 222-7 (1991) BindingDB Entry DOI: 10.7270/Q2XD10N1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Homo sapiens (Human)) | BDBM50010931 (2-{4-[2-(2,4-Diamino-pteridin-6-yl)-ethyl]-benzoyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 5.90 | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Alabama Curated by ChEMBL | Assay Description Compound was tested for its inhibitory activity on Recombinant Human Dihydrofolate Reductase. | J Med Chem 34: 222-7 (1991) BindingDB Entry DOI: 10.7270/Q2XD10N1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Homo sapiens (Human)) | BDBM50010924 (2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-ami...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 6.40 | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Alabama Curated by ChEMBL | Assay Description Compound was tested for its inhibitory activity on Recombinant Human Dihydrofolate Reductase. | J Med Chem 34: 222-7 (1991) BindingDB Entry DOI: 10.7270/Q2XD10N1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Homo sapiens (Human)) | BDBM50010929 (2-{4-[2-(2,4-Diamino-pteridin-6-yl)-ethyl]-benzoyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 8.80 | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Alabama Curated by ChEMBL | Assay Description Compound was tested for its inhibitory activity on Recombinant Human Dihydrofolate Reductase. | J Med Chem 34: 222-7 (1991) BindingDB Entry DOI: 10.7270/Q2XD10N1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Folylpolyglutamate synthase, mitochondrial (Homo sapiens (Human)) | BDBM50010931 (2-{4-[2-(2,4-Diamino-pteridin-6-yl)-ethyl]-benzoyl...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Alabama Curated by ChEMBL | Assay Description Compound was evaluated for the inhibition of Folyl-polyglutamate synthase in CCRF-CEM Human leukemia cell. | J Med Chem 34: 222-7 (1991) BindingDB Entry DOI: 10.7270/Q2XD10N1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Folylpolyglutamate synthase, mitochondrial (Homo sapiens (Human)) | BDBM50010928 (2-{4-[1-(2,4-Diamino-pteridin-6-ylmethyl)-propyl]-...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.18E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Alabama Curated by ChEMBL | Assay Description Compound was evaluated for the inhibition of Folyl-polyglutamate synthase in CCRF-CEM Human leukemia cell. | J Med Chem 34: 222-7 (1991) BindingDB Entry DOI: 10.7270/Q2XD10N1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Folylpolyglutamate synthase, mitochondrial (Homo sapiens (Human)) | BDBM50010924 (2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-ami...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Alabama Curated by ChEMBL | Assay Description Compound was evaluated for the inhibition of Folyl-polyglutamate synthase in CCRF-CEM Human leukemia cell. | J Med Chem 34: 222-7 (1991) BindingDB Entry DOI: 10.7270/Q2XD10N1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Folylpolyglutamate synthase, mitochondrial (Homo sapiens (Human)) | BDBM50010929 (2-{4-[2-(2,4-Diamino-pteridin-6-yl)-ethyl]-benzoyl...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Alabama Curated by ChEMBL | Assay Description Compound was evaluated for the inhibition of Folyl-polyglutamate synthase in CCRF-CEM Human leukemia cell. | J Med Chem 34: 222-7 (1991) BindingDB Entry DOI: 10.7270/Q2XD10N1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Folylpolyglutamate synthase, mitochondrial (Homo sapiens (Human)) | BDBM50010930 (2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-ami...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Alabama Curated by ChEMBL | Assay Description Compound was evaluated for the inhibition of Folyl-polyglutamate synthase in CCRF-CEM Human leukemia cell. | J Med Chem 34: 222-7 (1991) BindingDB Entry DOI: 10.7270/Q2XD10N1 | |||||||||||
More data for this Ligand-Target Pair |