Found 6 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50415240
(CHEMBL595737)Show SMILES Cc1cc(cc2C(Nc3cncc(Cl)c3)C(=NNc12)C(N)=O)S(C)(=O)=O |c:16| Show InChI InChI=1S/C16H16ClN5O3S/c1-8-3-11(26(2,24)25)5-12-13(8)21-22-15(16(18)23)14(12)20-10-4-9(17)6-19-7-10/h3-7,14,20-21H,1-2H3,(H2,18,23) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.0794 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of PDE4B catalytic domain by scintillation proximity assay |
Bioorg Med Chem Lett 20: 137-40 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4KPG |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50415241
(CHEMBL595549)Show SMILES CCn1nccc1NC1C(=NNc2c(C)cc(cc12)S(=O)(=O)CC)C(N)=O |c:10| Show InChI InChI=1S/C17H22N6O3S/c1-4-23-13(6-7-19-23)20-15-12-9-11(27(25,26)5-2)8-10(3)14(12)21-22-16(15)17(18)24/h6-9,15,20-21H,4-5H2,1-3H3,(H2,18,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.316 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of PDE4B catalytic domain by scintillation proximity assay |
Bioorg Med Chem Lett 20: 137-40 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4KPG |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50415243
(CHEMBL605095)Show SMILES CC(C)(C)S(=O)(=O)c1ccc2NN=C(C(Nc3cncc(F)c3)c2c1)C(N)=O |c:12| Show InChI InChI=1S/C18H20FN5O3S/c1-18(2,3)28(26,27)12-4-5-14-13(7-12)15(16(17(20)25)24-23-14)22-11-6-10(19)8-21-9-11/h4-9,15,22-23H,1-3H3,(H2,20,25) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.501 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of PDE4B catalytic domain by scintillation proximity assay |
Bioorg Med Chem Lett 20: 137-40 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4KPG |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50415244
(CHEMBL595054)Show SMILES CS(=O)(=O)c1cc(F)c2NN=C(C(Nc3cncc(F)c3)c2c1)C(N)=O |c:10| Show InChI InChI=1S/C15H13F2N5O3S/c1-26(24,25)9-3-10-12(11(17)4-9)21-22-14(15(18)23)13(10)20-8-2-7(16)5-19-6-8/h2-6,13,20-21H,1H3,(H2,18,23) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.631 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of PDE4B catalytic domain by scintillation proximity assay |
Bioorg Med Chem Lett 20: 137-40 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4KPG |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50415242
(CHEMBL595745)Show SMILES CS(=O)(=O)c1ccc2NN=C(C(Nc3cncc(Cl)c3)c2c1)C(N)=O |c:9| Show InChI InChI=1S/C15H14ClN5O3S/c1-25(23,24)10-2-3-12-11(5-10)13(14(15(17)22)21-20-12)19-9-4-8(16)6-18-7-9/h2-7,13,19-20H,1H3,(H2,17,22) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.794 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of PDE4B catalytic domain by scintillation proximity assay |
Bioorg Med Chem Lett 20: 137-40 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4KPG |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50415245
(CHEMBL593894)Show SMILES Cc1cc(cc2c(Nc3cccc(c3)C#N)c(C(N)=O)c(=O)[nH]c12)S(C)(=O)=O Show InChI InChI=1S/C19H16N4O4S/c1-10-6-13(28(2,26)27)8-14-16(10)23-19(25)15(18(21)24)17(14)22-12-5-3-4-11(7-12)9-20/h3-8H,1-2H3,(H2,21,24)(H2,22,23,25) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of PDE4B catalytic domain by scintillation proximity assay |
Bioorg Med Chem Lett 20: 137-40 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4KPG |
More data for this
Ligand-Target Pair | |
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