Found 39 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305129
(6-(2-aminoethoxy)-2-(4-phenoxyphenyl)-9,10-dihydro...)Show SMILES NCCOc1ccc2CCn3nc(c(C(N)=O)c3Nc2c1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C26H25N5O3/c27-13-15-33-21-11-6-17-12-14-31-26(29-22(17)16-21)23(25(28)32)24(30-31)18-7-9-20(10-8-18)34-19-4-2-1-3-5-19/h1-11,16,29H,12-15,27H2,(H2,28,32) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305140
(7-(2-aminoethoxy)-2-(4-phenoxyphenyl)-9,10-dihydro...)Show SMILES NCCOc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C26H25N5O3/c27-13-15-33-21-10-11-22-18(16-21)12-14-31-26(29-22)23(25(28)32)24(30-31)17-6-8-20(9-7-17)34-19-4-2-1-3-5-19/h1-11,16,29H,12-15,27H2,(H2,28,32) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.410 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305119
(7-(2-(dimethylamino)ethoxy)-2-(4-hydroxyphenyl)-9,...)Show SMILES CN(C)CCOc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(O)cc1 Show InChI InChI=1S/C22H25N5O3/c1-26(2)11-12-30-17-7-8-18-15(13-17)9-10-27-22(24-18)19(21(23)29)20(25-27)14-3-5-16(28)6-4-14/h3-8,13,24,28H,9-12H2,1-2H3,(H2,23,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.440 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305131
(6-(3-(dimethylamino)propoxy)-2-(4-phenoxyphenyl)-9...)Show SMILES CN(C)CCCOc1ccc2CCn3nc(c(C(N)=O)c3Nc2c1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C29H31N5O3/c1-33(2)16-6-18-36-24-14-9-20-15-17-34-29(31-25(20)19-24)26(28(30)35)27(32-34)21-10-12-23(13-11-21)37-22-7-4-3-5-8-22/h3-5,7-14,19,31H,6,15-18H2,1-2H3,(H2,30,35) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.510 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305139
(6-(2-(4-methylpiperazin-1-yl)ethoxy)-2-(4-phenoxyp...)Show SMILES CN1CCN(CCOc2ccc3CCn4nc(c(C(N)=O)c4Nc3c2)-c2ccc(Oc3ccccc3)cc2)CC1 Show InChI InChI=1S/C31H34N6O3/c1-35-15-17-36(18-16-35)19-20-39-26-12-7-22-13-14-37-31(33-27(22)21-26)28(30(32)38)29(34-37)23-8-10-25(11-9-23)40-24-5-3-2-4-6-24/h2-12,21,33H,13-20H2,1H3,(H2,32,38) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.550 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305117
(7-(2-morpholinoethoxy)-2-(4-phenoxyphenyl)-9,10-di...)Show SMILES NC(=O)c1c2Nc3ccc(OCCN4CCOCC4)cc3CCn2nc1-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C30H31N5O4/c31-29(36)27-28(21-6-8-24(9-7-21)39-23-4-2-1-3-5-23)33-35-13-12-22-20-25(10-11-26(22)32-30(27)35)38-19-16-34-14-17-37-18-15-34/h1-11,20,32H,12-19H2,(H2,31,36) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.560 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50305126
(7-(2-(dimethylamino)ethoxy)-2-(4-phenoxyphenyl)-9,...)Show SMILES CN(C)CCOc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C28H29N5O3/c1-32(2)16-17-35-23-12-13-24-20(18-23)14-15-33-28(30-24)25(27(29)34)26(31-33)19-8-10-22(11-9-19)36-21-6-4-3-5-7-21/h3-13,18,30H,14-17H2,1-2H3,(H2,29,34) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of SRC |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305126
(7-(2-(dimethylamino)ethoxy)-2-(4-phenoxyphenyl)-9,...)Show SMILES CN(C)CCOc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C28H29N5O3/c1-32(2)16-17-35-23-12-13-24-20(18-23)14-15-33-28(30-24)25(27(29)34)26(31-33)19-8-10-22(11-9-19)36-21-6-4-3-5-7-21/h3-13,18,30H,14-17H2,1-2H3,(H2,29,34) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.720 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305142
(7-(2-hydroxyethoxy)-2-(4-phenoxyphenyl)-9,10-dihyd...)Show SMILES NC(=O)c1c2Nc3ccc(OCCO)cc3CCn2nc1-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C26H24N4O4/c27-25(32)23-24(17-6-8-20(9-7-17)34-19-4-2-1-3-5-19)29-30-13-12-18-16-21(33-15-14-31)10-11-22(18)28-26(23)30/h1-11,16,28,31H,12-15H2,(H2,27,32) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.75 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305138
(6-(2-morpholinoethoxy)-2-(4-phenoxyphenyl)-9,10-di...)Show SMILES NC(=O)c1c2Nc3cc(OCCN4CCOCC4)ccc3CCn2nc1-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C30H31N5O4/c31-29(36)27-28(22-7-9-24(10-8-22)39-23-4-2-1-3-5-23)33-35-13-12-21-6-11-25(20-26(21)32-30(27)35)38-19-16-34-14-17-37-18-15-34/h1-11,20,32H,12-19H2,(H2,31,36) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.770 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305121
(7-(2-(dimethylamino)ethoxy)-2-(4-(phenylamino)phen...)Show SMILES CN(C)CCOc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(Nc2ccccc2)cc1 Show InChI InChI=1S/C28H30N6O2/c1-33(2)16-17-36-23-12-13-24-20(18-23)14-15-34-28(31-24)25(27(29)35)26(32-34)19-8-10-22(11-9-19)30-21-6-4-3-5-7-21/h3-13,18,30-31H,14-17H2,1-2H3,(H2,29,35) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305125
(2-(4-(3-(2,6-dichlorophenyl)ureido)phenyl)-7-(2-(d...)Show SMILES CN(C)CCOc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(NC(=O)Nc2c(Cl)cccc2Cl)cc1 Show InChI InChI=1S/C29H29Cl2N7O3/c1-37(2)14-15-41-20-10-11-23-18(16-20)12-13-38-28(34-23)24(27(32)39)25(36-38)17-6-8-19(9-7-17)33-29(40)35-26-21(30)4-3-5-22(26)31/h3-11,16,34H,12-15H2,1-2H3,(H2,32,39)(H2,33,35,40) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.940 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305141
(7-(3-(dimethylamino)propoxy)-2-(4-phenoxyphenyl)-9...)Show SMILES CN(C)CCCOc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C29H31N5O3/c1-33(2)16-6-18-36-24-13-14-25-21(19-24)15-17-34-29(31-25)26(28(30)35)27(32-34)20-9-11-23(12-10-20)37-22-7-4-3-5-8-22/h3-5,7-14,19,31H,6,15-18H2,1-2H3,(H2,30,35) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305135
(2-(3-carbamoyl-2-(4-phenoxyphenyl)-9,10-dihydro-4H...)Show SMILES NC(=O)c1c2Nc3cc(OCC(O)=O)ccc3CCn2nc1-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C26H22N4O5/c27-25(33)23-24(17-7-9-19(10-8-17)35-18-4-2-1-3-5-18)29-30-13-12-16-6-11-20(34-15-22(31)32)14-21(16)28-26(23)30/h1-11,14,28H,12-13,15H2,(H2,27,33)(H,31,32) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305122
(2-(4-(2,6-dichlorobenzylamino)phenyl)-7-(2-(dimeth...)Show SMILES CN(C)CCOc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(NCc2c(Cl)cccc2Cl)cc1 Show InChI InChI=1S/C29H30Cl2N6O2/c1-36(2)14-15-39-21-10-11-25-19(16-21)12-13-37-29(34-25)26(28(32)38)27(35-37)18-6-8-20(9-7-18)33-17-22-23(30)4-3-5-24(22)31/h3-11,16,33-34H,12-15,17H2,1-2H3,(H2,32,38) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305118
(7-(2-(4-methylpiperazin-1-yl)ethoxy)-2-(4-phenoxyp...)Show SMILES CN1CCN(CCOc2ccc3Nc4c(C(N)=O)c(nn4CCc3c2)-c2ccc(Oc3ccccc3)cc2)CC1 Show InChI InChI=1S/C31H34N6O3/c1-35-15-17-36(18-16-35)19-20-39-26-11-12-27-23(21-26)13-14-37-31(33-27)28(30(32)38)29(34-37)22-7-9-25(10-8-22)40-24-5-3-2-4-6-24/h2-12,21,33H,13-20H2,1H3,(H2,32,38) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305143
(7-(2-amino-2-oxoethoxy)-2-(4-phenoxyphenyl)-9,10-d...)Show SMILES NC(=O)COc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C26H23N5O4/c27-22(32)15-34-20-10-11-21-17(14-20)12-13-31-26(29-21)23(25(28)33)24(30-31)16-6-8-19(9-7-16)35-18-4-2-1-3-5-18/h1-11,14,29H,12-13,15H2,(H2,27,32)(H2,28,33) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305130
(6-(2-(dimethylamino)ethoxy)-2-(4-phenoxyphenyl)-9,...)Show SMILES CN(C)CCOc1ccc2CCn3nc(c(C(N)=O)c3Nc2c1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C28H29N5O3/c1-32(2)16-17-35-23-13-8-19-14-15-33-28(30-24(19)18-23)25(27(29)34)26(31-33)20-9-11-22(12-10-20)36-21-6-4-3-5-7-21/h3-13,18,30H,14-17H2,1-2H3,(H2,29,34) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305134
(6-(2-amino-2-oxoethoxy)-2-(4-phenoxyphenyl)-9,10-d...)Show SMILES NC(=O)COc1ccc2CCn3nc(c(C(N)=O)c3Nc2c1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C26H23N5O4/c27-22(32)15-34-20-11-6-16-12-13-31-26(29-21(16)14-20)23(25(28)33)24(30-31)17-7-9-19(10-8-17)35-18-4-2-1-3-5-18/h1-11,14,29H,12-13,15H2,(H2,27,32)(H2,28,33) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305132
(6-(2-hydroxyethoxy)-2-(4-phenoxyphenyl)-9,10-dihyd...)Show SMILES NC(=O)c1c2Nc3cc(OCCO)ccc3CCn2nc1-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C26H24N4O4/c27-25(32)23-24(18-7-9-20(10-8-18)34-19-4-2-1-3-5-19)29-30-13-12-17-6-11-21(33-15-14-31)16-22(17)28-26(23)30/h1-11,16,28,31H,12-15H2,(H2,27,32) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase CSK
(Homo sapiens (Human)) | BDBM50305126
(7-(2-(dimethylamino)ethoxy)-2-(4-phenoxyphenyl)-9,...)Show SMILES CN(C)CCOc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C28H29N5O3/c1-32(2)16-17-35-23-12-13-24-20(18-23)14-15-33-28(30-24)25(27(29)34)26(31-33)19-8-10-22(11-9-19)36-21-6-4-3-5-7-21/h3-13,18,30H,14-17H2,1-2H3,(H2,29,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of Csk |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305123
(CHEMBL595625 | benzyl 4-(3-carbamoyl-7-(2-(dimethy...)Show SMILES CN(C)CCOc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(NC(=O)OCc2ccccc2)cc1 Show InChI InChI=1S/C30H32N6O4/c1-35(2)16-17-39-24-12-13-25-22(18-24)14-15-36-29(33-25)26(28(31)37)27(34-36)21-8-10-23(11-9-21)32-30(38)40-19-20-6-4-3-5-7-20/h3-13,18,33H,14-17,19H2,1-2H3,(H2,31,37)(H,32,38) | PDB
UniProtKB/SwissProt
antibodypedia
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| CHEMBL
PC cid
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UniChem
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| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305124
(7-(2-(dimethylamino)ethoxy)-2-(4-(3-phenylureido)p...)Show SMILES CN(C)CCOc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(NC(=O)Nc2ccccc2)cc1 Show InChI InChI=1S/C29H31N7O3/c1-35(2)16-17-39-23-12-13-24-20(18-23)14-15-36-28(33-24)25(27(30)37)26(34-36)19-8-10-22(11-9-19)32-29(38)31-21-6-4-3-5-7-21/h3-13,18,33H,14-17H2,1-2H3,(H2,30,37)(H2,31,32,38) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305128
(7-methoxy-2-(4-phenoxyphenyl)-9,10-dihydro-4H-benz...)Show SMILES COc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C25H22N4O3/c1-31-20-11-12-21-17(15-20)13-14-29-25(27-21)22(24(26)30)23(28-29)16-7-9-19(10-8-16)32-18-5-3-2-4-6-18/h2-12,15,27H,13-14H2,1H3,(H2,26,30) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305145
(2-(4-phenoxyphenyl)-7-(pyridin-3-ylmethoxy)-9,10-d...)Show SMILES NC(=O)c1c2Nc3ccc(OCc4cccnc4)cc3CCn2nc1-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C30H25N5O3/c31-29(36)27-28(21-8-10-24(11-9-21)38-23-6-2-1-3-7-23)34-35-16-14-22-17-25(12-13-26(22)33-30(27)35)37-19-20-5-4-15-32-18-20/h1-13,15,17-18,33H,14,16,19H2,(H2,31,36) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305120
(2-(4-aminophenyl)-7-(2-(dimethylamino)ethoxy)-9,10...)Show SMILES CN(C)CCOc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(N)cc1 Show InChI InChI=1S/C22H26N6O2/c1-27(2)11-12-30-17-7-8-18-15(13-17)9-10-28-22(25-18)19(21(24)29)20(26-28)14-3-5-16(23)6-4-14/h3-8,13,25H,9-12,23H2,1-2H3,(H2,24,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305136
(6-(2-oxopropoxy)-2-(4-phenoxyphenyl)-9,10-dihydro-...)Show SMILES CC(=O)COc1ccc2CCn3nc(c(C(N)=O)c3Nc2c1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C27H24N4O4/c1-17(32)16-34-22-12-7-18-13-14-31-27(29-23(18)15-22)24(26(28)33)25(30-31)19-8-10-21(11-9-19)35-20-5-3-2-4-6-20/h2-12,15,29H,13-14,16H2,1H3,(H2,28,33) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305127
(6-methoxy-2-(4-phenoxyphenyl)-9,10-dihydro-4H-benz...)Show SMILES COc1ccc2CCn3nc(c(C(N)=O)c3Nc2c1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C25H22N4O3/c1-31-20-12-7-16-13-14-29-25(27-21(16)15-20)22(24(26)30)23(28-29)17-8-10-19(11-9-17)32-18-5-3-2-4-6-18/h2-12,15,27H,13-14H2,1H3,(H2,26,30) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305144
(2-(4-phenoxyphenyl)-7-(pyridin-2-ylmethoxy)-9,10-d...)Show SMILES NC(=O)c1c2Nc3ccc(OCc4ccccn4)cc3CCn2nc1-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C30H25N5O3/c31-29(36)27-28(20-9-11-24(12-10-20)38-23-7-2-1-3-8-23)34-35-17-15-21-18-25(13-14-26(21)33-30(27)35)37-19-22-6-4-5-16-32-22/h1-14,16,18,33H,15,17,19H2,(H2,31,36) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305137
(2-(4-phenoxyphenyl)-6-(pyridin-3-ylmethoxy)-9,10-d...)Show SMILES NC(=O)c1c2Nc3cc(OCc4cccnc4)ccc3CCn2nc1-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C30H25N5O3/c31-29(36)27-28(22-9-11-24(12-10-22)38-23-6-2-1-3-7-23)34-35-16-14-21-8-13-25(17-26(21)33-30(27)35)37-19-20-5-4-15-32-18-20/h1-13,15,17-18,33H,14,16,19H2,(H2,31,36) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305116
(2-(4-phenoxyphenyl)-7-(pyridin-4-ylmethoxy)-9,10-d...)Show SMILES NC(=O)c1c2Nc3ccc(OCc4ccncc4)cc3CCn2nc1-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C30H25N5O3/c31-29(36)27-28(21-6-8-24(9-7-21)38-23-4-2-1-3-5-23)34-35-17-14-22-18-25(10-11-26(22)33-30(27)35)37-19-20-12-15-32-16-13-20/h1-13,15-16,18,33H,14,17,19H2,(H2,31,36) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305133
(6-(4-methylpentyloxy)-2-(4-phenoxyphenyl)-9,10-dih...)Show SMILES CC(C)CCCOc1ccc2CCn3nc(c(C(N)=O)c3Nc2c1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C30H32N4O3/c1-20(2)7-6-18-36-25-15-10-21-16-17-34-30(32-26(21)19-25)27(29(31)35)28(33-34)22-11-13-24(14-12-22)37-23-8-4-3-5-9-23/h3-5,8-15,19-20,32H,6-7,16-18H2,1-2H3,(H2,31,35) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase ZAP-70
(Homo sapiens (Human)) | BDBM50305126
(7-(2-(dimethylamino)ethoxy)-2-(4-phenoxyphenyl)-9,...)Show SMILES CN(C)CCOc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C28H29N5O3/c1-32(2)16-17-35-23-12-13-24-20(18-23)14-15-33-28(30-24)25(27(29)34)26(31-33)19-8-10-22(11-9-19)36-21-6-4-3-5-7-21/h3-13,18,30H,14-17H2,1-2H3,(H2,29,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of Zap70 |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (Human)) | BDBM50305126
(7-(2-(dimethylamino)ethoxy)-2-(4-phenoxyphenyl)-9,...)Show SMILES CN(C)CCOc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C28H29N5O3/c1-32(2)16-17-35-23-12-13-24-20(18-23)14-15-33-28(30-24)25(27(29)34)26(31-33)19-8-10-22(11-9-19)36-21-6-4-3-5-7-21/h3-13,18,30H,14-17H2,1-2H3,(H2,29,34) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of CDK1 |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this
Ligand-Target Pair | |
Calcium/calmodulin-dependent protein kinase type IV
(Homo sapiens (Human)) | BDBM50305126
(7-(2-(dimethylamino)ethoxy)-2-(4-phenoxyphenyl)-9,...)Show SMILES CN(C)CCOc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C28H29N5O3/c1-32(2)16-17-35-23-12-13-24-20(18-23)14-15-33-28(30-24)25(27(29)34)26(31-33)19-8-10-22(11-9-19)36-21-6-4-3-5-7-21/h3-13,18,30H,14-17H2,1-2H3,(H2,29,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of CamK4 |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this
Ligand-Target Pair | |
Protein kinase C alpha type
(Homo sapiens (Human)) | BDBM50305126
(7-(2-(dimethylamino)ethoxy)-2-(4-phenoxyphenyl)-9,...)Show SMILES CN(C)CCOc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C28H29N5O3/c1-32(2)16-17-35-23-12-13-24-20(18-23)14-15-33-28(30-24)25(27(29)34)26(31-33)19-8-10-22(11-9-19)36-21-6-4-3-5-7-21/h3-13,18,30H,14-17H2,1-2H3,(H2,29,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of PKCalpha |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50305126
(7-(2-(dimethylamino)ethoxy)-2-(4-phenoxyphenyl)-9,...)Show SMILES CN(C)CCOc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C28H29N5O3/c1-32(2)16-17-35-23-12-13-24-20(18-23)14-15-33-28(30-24)25(27(29)34)26(31-33)19-8-10-22(11-9-19)36-21-6-4-3-5-7-21/h3-13,18,30H,14-17H2,1-2H3,(H2,29,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of MAPK1 |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this
Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50305126
(7-(2-(dimethylamino)ethoxy)-2-(4-phenoxyphenyl)-9,...)Show SMILES CN(C)CCOc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C28H29N5O3/c1-32(2)16-17-35-23-12-13-24-20(18-23)14-15-33-28(30-24)25(27(29)34)26(31-33)19-8-10-22(11-9-19)36-21-6-4-3-5-7-21/h3-13,18,30H,14-17H2,1-2H3,(H2,29,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of MEK1 |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50305126
(7-(2-(dimethylamino)ethoxy)-2-(4-phenoxyphenyl)-9,...)Show SMILES CN(C)CCOc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C28H29N5O3/c1-32(2)16-17-35-23-12-13-24-20(18-23)14-15-33-28(30-24)25(27(29)34)26(31-33)19-8-10-22(11-9-19)36-21-6-4-3-5-7-21/h3-13,18,30H,14-17H2,1-2H3,(H2,29,34) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of PKBalpha |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013
BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this
Ligand-Target Pair | |
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