Affinity Data by PubMed id=19950901

PubMed code 19950901

Found 23 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50314073 (3-(3-bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-ox...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB PDB Article PubMed	5.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Roche Palo Alto Curated by ChEMBL					Assay Description Binding affinity to p38alpha				J Med Chem 53: 2345-53 (2010) Article DOI: 10.1021/jm9012906 BindingDB Entry DOI: 10.7270/Q27H1JQC
Roche Palo Alto Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50418610 (GW-856553 \| GW856553X \| LOSMAPIMOD \| US10550073, C...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	7.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Roche Palo Alto Curated by ChEMBL					Assay Description Binding affinity to p38alpha				J Med Chem 53: 2345-53 (2010) Article DOI: 10.1021/jm9012906 BindingDB Entry DOI: 10.7270/Q27H1JQC
Roche Palo Alto Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 11 (Homo sapiens (Human))	BDBM50418610 (GW-856553 \| GW856553X \| LOSMAPIMOD \| US10550073, C...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	25	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Roche Palo Alto Curated by ChEMBL					Assay Description Binding affinity to p38beta				J Med Chem 53: 2345-53 (2010) Article DOI: 10.1021/jm9012906 BindingDB Entry DOI: 10.7270/Q27H1JQC
Roche Palo Alto Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50314072 (5-(2,4-difluorophenoxy)-N-(2-(dimethylamino)ethyl)...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
Roche Palo Alto Curated by ChEMBL					Assay Description Inhibition of human recombinant p38alpha by liquid scintillation counting				J Med Chem 53: 2345-53 (2010) Article DOI: 10.1021/jm9012906 BindingDB Entry DOI: 10.7270/Q27H1JQC
Roche Palo Alto Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50266947 (2-(6-chloro-5-((2R,5S)-4-(4-fluorobenzyl)-2,5-dime...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Roche Palo Alto Curated by ChEMBL					Assay Description Inhibition of human recombinant p38alpha by liquid scintillation counting				J Med Chem 53: 2345-53 (2010) Article DOI: 10.1021/jm9012906 BindingDB Entry DOI: 10.7270/Q27H1JQC
Roche Palo Alto Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM15244 (5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfa...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Roche Palo Alto Curated by ChEMBL					Assay Description Inhibition of human recombinant p38alpha by liquid scintillation counting				J Med Chem 53: 2345-53 (2010) Article DOI: 10.1021/jm9012906 BindingDB Entry DOI: 10.7270/Q27H1JQC
Roche Palo Alto Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50314070 (6-(2,4-difluorophenoxy)-2-{[3-hydroxy-1-(2-hydroxy...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Roche Palo Alto Curated by ChEMBL					Assay Description Inhibition of human recombinant p38alpha by liquid scintillation counting				J Med Chem 53: 2345-53 (2010) Article DOI: 10.1021/jm9012906 BindingDB Entry DOI: 10.7270/Q27H1JQC
Roche Palo Alto Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Mitogen-activated protein kinase 9 (Homo sapiens (Human))	BDBM50314070 (6-(2,4-difluorophenoxy)-2-{[3-hydroxy-1-(2-hydroxy...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a
Roche Palo Alto Curated by ChEMBL					Assay Description Binding affinity to JNK2				J Med Chem 53: 2345-53 (2010) Article DOI: 10.1021/jm9012906 BindingDB Entry DOI: 10.7270/Q27H1JQC
Roche Palo Alto Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM50314071 (2-(2,4-difluorophenyl)-6-(1-(2,6-difluorophenyl)ur...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	780	n/a	n/a	n/a	n/a	n/a
Roche Palo Alto Curated by ChEMBL					Assay Description Binding affinity to JNK3				J Med Chem 53: 2345-53 (2010) Article DOI: 10.1021/jm9012906 BindingDB Entry DOI: 10.7270/Q27H1JQC
Roche Palo Alto Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50266947 (2-(6-chloro-5-((2R,5S)-4-(4-fluorobenzyl)-2,5-dime...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	0.480	n/a	n/a	n/a	n/a	n/a
Roche Palo Alto Curated by ChEMBL					Assay Description Binding affinity to p38alpha				J Med Chem 53: 2345-53 (2010) Article DOI: 10.1021/jm9012906 BindingDB Entry DOI: 10.7270/Q27H1JQC
Roche Palo Alto Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Activin receptor type-2B (Homo sapiens (Human))	BDBM50314071 (2-(2,4-difluorophenyl)-6-(1-(2,6-difluorophenyl)ur...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	92	n/a	n/a	n/a	n/a	n/a
Roche Palo Alto Curated by ChEMBL					Assay Description Binding affinity to ACVR2beta				J Med Chem 53: 2345-53 (2010) Article DOI: 10.1021/jm9012906 BindingDB Entry DOI: 10.7270/Q27H1JQC
Roche Palo Alto Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM50314070 (6-(2,4-difluorophenoxy)-2-{[3-hydroxy-1-(2-hydroxy...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a
Roche Palo Alto Curated by ChEMBL					Assay Description Binding affinity to JNK1				J Med Chem 53: 2345-53 (2010) Article DOI: 10.1021/jm9012906 BindingDB Entry DOI: 10.7270/Q27H1JQC
Roche Palo Alto Curated by ChEMBL					More data for this Ligand-Target Pair
Casein kinase I isoform epsilon (Homo sapiens (Human))	BDBM50314070 (6-(2,4-difluorophenoxy)-2-{[3-hydroxy-1-(2-hydroxy...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a
Roche Palo Alto Curated by ChEMBL					Assay Description Binding affinity to CSNK1epsilon				J Med Chem 53: 2345-53 (2010) Article DOI: 10.1021/jm9012906 BindingDB Entry DOI: 10.7270/Q27H1JQC
Roche Palo Alto Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase NLK (Homo sapiens (Human))	BDBM50314071 (2-(2,4-difluorophenyl)-6-(1-(2,6-difluorophenyl)ur...) Show SMILES Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a
Roche Palo Alto Curated by ChEMBL					Assay Description Binding affinity to NLK				J Med Chem 53: 2345-53 (2010) Article DOI: 10.1021/jm9012906 BindingDB Entry DOI: 10.7270/Q27H1JQC
Roche Palo Alto Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50314070 (6-(2,4-difluorophenoxy)-2-{[3-hydroxy-1-(2-hydroxy...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a
Roche Palo Alto Curated by ChEMBL					Assay Description Binding affinity to p38alpha				J Med Chem 53: 2345-53 (2010) Article DOI: 10.1021/jm9012906 BindingDB Entry DOI: 10.7270/Q27H1JQC
Roche Palo Alto Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Mitogen-activated protein kinase 11 (Homo sapiens (Human))	BDBM50314070 (6-(2,4-difluorophenoxy)-2-{[3-hydroxy-1-(2-hydroxy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a
Roche Palo Alto Curated by ChEMBL					Assay Description Binding affinity to p38beta				J Med Chem 53: 2345-53 (2010) Article DOI: 10.1021/jm9012906 BindingDB Entry DOI: 10.7270/Q27H1JQC
Roche Palo Alto Curated by ChEMBL					More data for this Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (Homo sapiens (Human))	BDBM50314071 (2-(2,4-difluorophenyl)-6-(1-(2,6-difluorophenyl)ur...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a
Roche Palo Alto Curated by ChEMBL					Assay Description Binding affinity to PIK4Cbeta				J Med Chem 53: 2345-53 (2010) Article DOI: 10.1021/jm9012906 BindingDB Entry DOI: 10.7270/Q27H1JQC
Roche Palo Alto Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 9 (Homo sapiens (Human))	BDBM50314071 (2-(2,4-difluorophenyl)-6-(1-(2,6-difluorophenyl)ur...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a
Roche Palo Alto Curated by ChEMBL					Assay Description Binding affinity to JNK2				J Med Chem 53: 2345-53 (2010) Article DOI: 10.1021/jm9012906 BindingDB Entry DOI: 10.7270/Q27H1JQC
Roche Palo Alto Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 11 (Homo sapiens (Human))	BDBM50314071 (2-(2,4-difluorophenyl)-6-(1-(2,6-difluorophenyl)ur...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a
Roche Palo Alto Curated by ChEMBL					Assay Description Binding affinity to p38beta				J Med Chem 53: 2345-53 (2010) Article DOI: 10.1021/jm9012906 BindingDB Entry DOI: 10.7270/Q27H1JQC
Roche Palo Alto Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 11 (Homo sapiens (Human))	BDBM50266947 (2-(6-chloro-5-((2R,5S)-4-(4-fluorobenzyl)-2,5-dime...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a
Roche Palo Alto Curated by ChEMBL					Assay Description Binding affinity to p38beta				J Med Chem 53: 2345-53 (2010) Article DOI: 10.1021/jm9012906 BindingDB Entry DOI: 10.7270/Q27H1JQC
Roche Palo Alto Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50314071 (2-(2,4-difluorophenyl)-6-(1-(2,6-difluorophenyl)ur...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a
Roche Palo Alto Curated by ChEMBL					Assay Description Binding affinity to p38alpha				J Med Chem 53: 2345-53 (2010) Article DOI: 10.1021/jm9012906 BindingDB Entry DOI: 10.7270/Q27H1JQC
Roche Palo Alto Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM50314070 (6-(2,4-difluorophenoxy)-2-{[3-hydroxy-1-(2-hydroxy...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a
Roche Palo Alto Curated by ChEMBL					Assay Description Binding affinity to JNK3				J Med Chem 53: 2345-53 (2010) Article DOI: 10.1021/jm9012906 BindingDB Entry DOI: 10.7270/Q27H1JQC
Roche Palo Alto Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase NLK (Homo sapiens (Human))	BDBM50314070 (6-(2,4-difluorophenoxy)-2-{[3-hydroxy-1-(2-hydroxy...) Show SMILES Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a
Roche Palo Alto Curated by ChEMBL					Assay Description Binding affinity to NLK				J Med Chem 53: 2345-53 (2010) Article DOI: 10.1021/jm9012906 BindingDB Entry DOI: 10.7270/Q27H1JQC
Roche Palo Alto Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%