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PubMed code 19954866

Compile data set for download or QSAR
Found 31 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM21393
PNG
(7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-o...)
Show SMILES CCCN(CCC)C1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3
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 0.800n/an/an/an/an/an/an/an/a



Universit£ di Napoli

Curated by ChEMBL


Assay Description
Displacement of [3H]8OH-DPAT from 5HT1A in Sprague-Dawley rat brain cortex by liquid scintillation counting

Eur J Med Chem 45: 752-9 (2010)


Article DOI: 10.1016/j.ejmech.2009.11.023
BindingDB Entry DOI: 10.7270/Q2445MJR
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM21395
PNG
(3-(2-(4-(4-Fluorobenzoyl)piperidinol)ethyl)-2,4(1H...)
Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CCn2c(=O)[nH]c3ccccc3c2=O)CC1
Show InChI InChI=1S/C22H22FN3O3/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29/h1-8,16H,9-14H2,(H,24,29)
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 0.850n/an/an/an/an/an/an/an/a



Universit£ di Napoli

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5HT2A in Sprague-Dawley rat brain cortex by liquid scintillation counting

Eur J Med Chem 45: 752-9 (2010)


Article DOI: 10.1016/j.ejmech.2009.11.023
BindingDB Entry DOI: 10.7270/Q2445MJR
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50300166
PNG
(CHEMBL566533 | Ethyl 5-(3-(4-(3-chlorophenyl)piper...)
Show SMILES CCOC(=O)c1cc2cc(OCCCN3CCN(CC3)c3cccc(Cl)c3)ccc2[nH]1
Show InChI InChI=1S/C24H28ClN3O3/c1-2-30-24(29)23-16-18-15-21(7-8-22(18)26-23)31-14-4-9-27-10-12-28(13-11-27)20-6-3-5-19(25)17-20/h3,5-8,15-17,26H,2,4,9-14H2,1H3
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 1.28n/an/an/an/an/an/an/an/a



Universit£ di Napoli

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine from 5HT2C in Sprague-Dawley rat brain cortex by liquid scintillation counting

Eur J Med Chem 45: 752-9 (2010)


Article DOI: 10.1016/j.ejmech.2009.11.023
BindingDB Entry DOI: 10.7270/Q2445MJR
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50300170
PNG
(CHEMBL568284 | Ethyl 5-(3-(4-(4-chlorophenyl)piper...)
Show SMILES CCOC(=O)c1cc2cc(OCCCN3CCN(CC3)c3ccc(Cl)cc3)ccc2[nH]1
Show InChI InChI=1S/C24H28ClN3O3/c1-2-30-24(29)23-17-18-16-21(8-9-22(18)26-23)31-15-3-10-27-11-13-28(14-12-27)20-6-4-19(25)5-7-20/h4-9,16-17,26H,2-3,10-15H2,1H3
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 14n/an/an/an/an/an/an/an/a



Universit£ di Napoli

Curated by ChEMBL


Assay Description
Displacement of [3H]8OH-DPAT from 5HT1A in Sprague-Dawley rat brain cortex by liquid scintillation counting

Eur J Med Chem 45: 752-9 (2010)


Article DOI: 10.1016/j.ejmech.2009.11.023
BindingDB Entry DOI: 10.7270/Q2445MJR
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50300159
PNG
(CHEMBL583422 | Ethyl 5-(3-(4-((benzo[d][1,3]dioxol...)
Show SMILES CCOC(=O)c1cc2cc(OCCCN3CCN(Cc4ccc5OCOc5c4)CC3)ccc2[nH]1
Show InChI InChI=1S/C26H31N3O5/c1-2-31-26(30)23-16-20-15-21(5-6-22(20)27-23)32-13-3-8-28-9-11-29(12-10-28)17-19-4-7-24-25(14-19)34-18-33-24/h4-7,14-16,27H,2-3,8-13,17-18H2,1H3
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 26.1n/an/an/an/an/an/an/an/a



Universit£ di Napoli

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5HT2A in Sprague-Dawley rat brain cortex by liquid scintillation counting

Eur J Med Chem 45: 752-9 (2010)


Article DOI: 10.1016/j.ejmech.2009.11.023
BindingDB Entry DOI: 10.7270/Q2445MJR
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50300165
PNG
(CHEMBL566331 | Ethyl 5-(3-(4-(3,4-dichlorophenyl)p...)
Show SMILES CCOC(=O)c1cc2cc(OCCCN3CCN(CC3)c3cccc(c3)C(F)(F)F)ccc2[nH]1
Show InChI InChI=1S/C25H28F3N3O3/c1-2-33-24(32)23-16-18-15-21(7-8-22(18)29-23)34-14-4-9-30-10-12-31(13-11-30)20-6-3-5-19(17-20)25(26,27)28/h3,5-8,15-17,29H,2,4,9-14H2,1H3
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 35.8n/an/an/an/an/an/an/an/a



Universit£ di Napoli

Curated by ChEMBL


Assay Description
Displacement of [3H]8OH-DPAT from 5HT1A in Sprague-Dawley rat brain cortex by liquid scintillation counting

Eur J Med Chem 45: 752-9 (2010)


Article DOI: 10.1016/j.ejmech.2009.11.023
BindingDB Entry DOI: 10.7270/Q2445MJR
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50300166
PNG
(CHEMBL566533 | Ethyl 5-(3-(4-(3-chlorophenyl)piper...)
Show SMILES CCOC(=O)c1cc2cc(OCCCN3CCN(CC3)c3cccc(Cl)c3)ccc2[nH]1
Show InChI InChI=1S/C24H28ClN3O3/c1-2-30-24(29)23-16-18-15-21(7-8-22(18)26-23)31-14-4-9-27-10-12-28(13-11-27)20-6-3-5-19(25)17-20/h3,5-8,15-17,26H,2,4,9-14H2,1H3
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 39n/an/an/an/an/an/an/an/a



Universit£ di Napoli

Curated by ChEMBL


Assay Description
Displacement of [3H]8OH-DPAT from 5HT1A in Sprague-Dawley rat brain cortex by liquid scintillation counting

Eur J Med Chem 45: 752-9 (2010)


Article DOI: 10.1016/j.ejmech.2009.11.023
BindingDB Entry DOI: 10.7270/Q2445MJR
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50300162
PNG
(CHEMBL586050 | Ethyl 5-(3-(4-(2-chlorophenyl)piper...)
Show SMILES CCOC(=O)c1cc2cc(OCCCN3CCN(CC3)c3ccccc3Cl)ccc2[nH]1
Show InChI InChI=1S/C24H28ClN3O3/c1-2-30-24(29)22-17-18-16-19(8-9-21(18)26-22)31-15-5-10-27-11-13-28(14-12-27)23-7-4-3-6-20(23)25/h3-4,6-9,16-17,26H,2,5,10-15H2,1H3
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 39.7n/an/an/an/an/an/an/an/a



Universit£ di Napoli

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine from 5HT2C in Sprague-Dawley rat brain cortex by liquid scintillation counting

Eur J Med Chem 45: 752-9 (2010)


Article DOI: 10.1016/j.ejmech.2009.11.023
BindingDB Entry DOI: 10.7270/Q2445MJR
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50300159
PNG
(CHEMBL583422 | Ethyl 5-(3-(4-((benzo[d][1,3]dioxol...)
Show SMILES CCOC(=O)c1cc2cc(OCCCN3CCN(Cc4ccc5OCOc5c4)CC3)ccc2[nH]1
Show InChI InChI=1S/C26H31N3O5/c1-2-31-26(30)23-16-20-15-21(5-6-22(20)27-23)32-13-3-8-28-9-11-29(12-10-28)17-19-4-7-24-25(14-19)34-18-33-24/h4-7,14-16,27H,2-3,8-13,17-18H2,1H3
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 43.6n/an/an/an/an/an/an/an/a



Universit£ di Napoli

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine from 5HT2C in Sprague-Dawley rat brain cortex by liquid scintillation counting

Eur J Med Chem 45: 752-9 (2010)


Article DOI: 10.1016/j.ejmech.2009.11.023
BindingDB Entry DOI: 10.7270/Q2445MJR
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50300170
PNG
(CHEMBL568284 | Ethyl 5-(3-(4-(4-chlorophenyl)piper...)
Show SMILES CCOC(=O)c1cc2cc(OCCCN3CCN(CC3)c3ccc(Cl)cc3)ccc2[nH]1
Show InChI InChI=1S/C24H28ClN3O3/c1-2-30-24(29)23-17-18-16-21(8-9-22(18)26-23)31-15-3-10-27-11-13-28(14-12-27)20-6-4-19(25)5-7-20/h4-9,16-17,26H,2-3,10-15H2,1H3
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 45.1n/an/an/an/an/an/an/an/a



Universit£ di Napoli

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine from 5HT2C in Sprague-Dawley rat brain cortex by liquid scintillation counting

Eur J Med Chem 45: 752-9 (2010)


Article DOI: 10.1016/j.ejmech.2009.11.023
BindingDB Entry DOI: 10.7270/Q2445MJR
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50300160
PNG
(CHEMBL565707 | Ethyl 5-(3-(4-(4-methoxyphenyl)pipe...)
Show SMILES CCOC(=O)c1cc2cc(OCCCN3CCN(CC3)c3ccc(OC)cc3)ccc2[nH]1
Show InChI InChI=1S/C25H31N3O4/c1-3-31-25(29)24-18-19-17-22(9-10-23(19)26-24)32-16-4-11-27-12-14-28(15-13-27)20-5-7-21(30-2)8-6-20/h5-10,17-18,26H,3-4,11-16H2,1-2H3
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 50.4n/an/an/an/an/an/an/an/a



Universit£ di Napoli

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine from 5HT2C in Sprague-Dawley rat brain cortex by liquid scintillation counting

Eur J Med Chem 45: 752-9 (2010)


Article DOI: 10.1016/j.ejmech.2009.11.023
BindingDB Entry DOI: 10.7270/Q2445MJR
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50300167
PNG
(CHEMBL567649 | Ethyl 5-(3-(4-(pyridin-2-yl)piperaz...)
Show SMILES CCOC(=O)c1cc2cc(OCCCN3CCN(CC3)c3ccccn3)ccc2[nH]1
Show InChI InChI=1S/C23H28N4O3/c1-2-29-23(28)21-17-18-16-19(7-8-20(18)25-21)30-15-5-10-26-11-13-27(14-12-26)22-6-3-4-9-24-22/h3-4,6-9,16-17,25H,2,5,10-15H2,1H3
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 104n/an/an/an/an/an/an/an/a



Universit£ di Napoli

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine from 5HT2C in Sprague-Dawley rat brain cortex by liquid scintillation counting

Eur J Med Chem 45: 752-9 (2010)


Article DOI: 10.1016/j.ejmech.2009.11.023
BindingDB Entry DOI: 10.7270/Q2445MJR
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50300168
PNG
(CHEMBL565484 | Ethyl 5-(3-(4-(4-nitrophenyl)pipera...)
Show SMILES CCOC(=O)c1cc2cc(OCCCN3CCN(CC3)c3ccc(cc3)[N+]([O-])=O)ccc2[nH]1
Show InChI InChI=1S/C24H28N4O5/c1-2-32-24(29)23-17-18-16-21(8-9-22(18)25-23)33-15-3-10-26-11-13-27(14-12-26)19-4-6-20(7-5-19)28(30)31/h4-9,16-17,25H,2-3,10-15H2,1H3
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 247n/an/an/an/an/an/an/an/a



Universit£ di Napoli

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine from 5HT2C in Sprague-Dawley rat brain cortex by liquid scintillation counting

Eur J Med Chem 45: 752-9 (2010)


Article DOI: 10.1016/j.ejmech.2009.11.023
BindingDB Entry DOI: 10.7270/Q2445MJR
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50300169
PNG
(CHEMBL584919 | Ethyl 5-(3-(4-(2-furoyl)piperazin-1...)
Show SMILES CCOC(=O)c1cc2cc(OCCCN3CCN(CC3)C(=O)c3ccco3)ccc2[nH]1
Show InChI InChI=1S/C23H27N3O5/c1-2-29-23(28)20-16-17-15-18(6-7-19(17)24-20)30-14-4-8-25-9-11-26(12-10-25)22(27)21-5-3-13-31-21/h3,5-7,13,15-16,24H,2,4,8-12,14H2,1H3
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 309n/an/an/an/an/an/an/an/a



Universit£ di Napoli

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine from 5HT2C in Sprague-Dawley rat brain cortex by liquid scintillation counting

Eur J Med Chem 45: 752-9 (2010)


Article DOI: 10.1016/j.ejmech.2009.11.023
BindingDB Entry DOI: 10.7270/Q2445MJR
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50300167
PNG
(CHEMBL567649 | Ethyl 5-(3-(4-(pyridin-2-yl)piperaz...)
Show SMILES CCOC(=O)c1cc2cc(OCCCN3CCN(CC3)c3ccccn3)ccc2[nH]1
Show InChI InChI=1S/C23H28N4O3/c1-2-29-23(28)21-17-18-16-19(7-8-20(18)25-21)30-15-5-10-26-11-13-27(14-12-26)22-6-3-4-9-24-22/h3-4,6-9,16-17,25H,2,5,10-15H2,1H3
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 344n/an/an/an/an/an/an/an/a



Universit£ di Napoli

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5HT2A in Sprague-Dawley rat brain cortex by liquid scintillation counting

Eur J Med Chem 45: 752-9 (2010)


Article DOI: 10.1016/j.ejmech.2009.11.023
BindingDB Entry DOI: 10.7270/Q2445MJR
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50300169
PNG
(CHEMBL584919 | Ethyl 5-(3-(4-(2-furoyl)piperazin-1...)
Show SMILES CCOC(=O)c1cc2cc(OCCCN3CCN(CC3)C(=O)c3ccco3)ccc2[nH]1
Show InChI InChI=1S/C23H27N3O5/c1-2-29-23(28)20-16-17-15-18(6-7-19(17)24-20)30-14-4-8-25-9-11-26(12-10-25)22(27)21-5-3-13-31-21/h3,5-7,13,15-16,24H,2,4,8-12,14H2,1H3
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 452n/an/an/an/an/an/an/an/a



Universit£ di Napoli

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5HT2A in Sprague-Dawley rat brain cortex by liquid scintillation counting

Eur J Med Chem 45: 752-9 (2010)


Article DOI: 10.1016/j.ejmech.2009.11.023
BindingDB Entry DOI: 10.7270/Q2445MJR
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50300162
PNG
(CHEMBL586050 | Ethyl 5-(3-(4-(2-chlorophenyl)piper...)
Show SMILES CCOC(=O)c1cc2cc(OCCCN3CCN(CC3)c3ccccc3Cl)ccc2[nH]1
Show InChI InChI=1S/C24H28ClN3O3/c1-2-30-24(29)22-17-18-16-19(8-9-21(18)26-22)31-15-5-10-27-11-13-28(14-12-27)23-7-4-3-6-20(23)25/h3-4,6-9,16-17,26H,2,5,10-15H2,1H3
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 537n/an/an/an/an/an/an/an/a



Universit£ di Napoli

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5HT2A in Sprague-Dawley rat brain cortex by liquid scintillation counting

Eur J Med Chem 45: 752-9 (2010)


Article DOI: 10.1016/j.ejmech.2009.11.023
BindingDB Entry DOI: 10.7270/Q2445MJR
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50300166
PNG
(CHEMBL566533 | Ethyl 5-(3-(4-(3-chlorophenyl)piper...)
Show SMILES CCOC(=O)c1cc2cc(OCCCN3CCN(CC3)c3cccc(Cl)c3)ccc2[nH]1
Show InChI InChI=1S/C24H28ClN3O3/c1-2-30-24(29)23-16-18-15-21(7-8-22(18)26-23)31-14-4-9-27-10-12-28(13-11-27)20-6-3-5-19(25)17-20/h3,5-8,15-17,26H,2,4,9-14H2,1H3
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 1.07E+3n/an/an/an/an/an/an/an/a



Universit£ di Napoli

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from dopamine D1 in rat striatum by liquid scintillation counting

Eur J Med Chem 45: 752-9 (2010)


Article DOI: 10.1016/j.ejmech.2009.11.023
BindingDB Entry DOI: 10.7270/Q2445MJR
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50300165
PNG
(CHEMBL566331 | Ethyl 5-(3-(4-(3,4-dichlorophenyl)p...)
Show SMILES CCOC(=O)c1cc2cc(OCCCN3CCN(CC3)c3cccc(c3)C(F)(F)F)ccc2[nH]1
Show InChI InChI=1S/C25H28F3N3O3/c1-2-33-24(32)23-16-18-15-21(7-8-22(18)29-23)34-14-4-9-30-10-12-31(13-11-30)20-6-3-5-19(17-20)25(26,27)28/h3,5-8,15-17,29H,2,4,9-14H2,1H3
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 3.61E+3n/an/an/an/an/an/an/an/a



Universit£ di Napoli

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5HT2A in Sprague-Dawley rat brain cortex by liquid scintillation counting

Eur J Med Chem 45: 752-9 (2010)


Article DOI: 10.1016/j.ejmech.2009.11.023
BindingDB Entry DOI: 10.7270/Q2445MJR
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50300159
PNG
(CHEMBL583422 | Ethyl 5-(3-(4-((benzo[d][1,3]dioxol...)
Show SMILES CCOC(=O)c1cc2cc(OCCCN3CCN(Cc4ccc5OCOc5c4)CC3)ccc2[nH]1
Show InChI InChI=1S/C26H31N3O5/c1-2-31-26(30)23-16-20-15-21(5-6-22(20)27-23)32-13-3-8-28-9-11-29(12-10-28)17-19-4-7-24-25(14-19)34-18-33-24/h4-7,14-16,27H,2-3,8-13,17-18H2,1H3
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 1.00E+4n/an/an/an/an/an/an/an/a



Universit£ di Napoli

Curated by ChEMBL


Assay Description
Displacement of [3H]8OH-DPAT from 5HT1A in Sprague-Dawley rat brain cortex by liquid scintillation counting

Eur J Med Chem 45: 752-9 (2010)


Article DOI: 10.1016/j.ejmech.2009.11.023
BindingDB Entry DOI: 10.7270/Q2445MJR
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50300168
PNG
(CHEMBL565484 | Ethyl 5-(3-(4-(4-nitrophenyl)pipera...)
Show SMILES CCOC(=O)c1cc2cc(OCCCN3CCN(CC3)c3ccc(cc3)[N+]([O-])=O)ccc2[nH]1
Show InChI InChI=1S/C24H28N4O5/c1-2-32-24(29)23-17-18-16-21(8-9-22(18)25-23)33-15-3-10-26-11-13-27(14-12-26)19-4-6-20(7-5-19)28(30)31/h4-9,16-17,25H,2-3,10-15H2,1H3
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 1.00E+4n/an/an/an/an/an/an/an/a



Universit£ di Napoli

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5HT2A in Sprague-Dawley rat brain cortex by liquid scintillation counting

Eur J Med Chem 45: 752-9 (2010)


Article DOI: 10.1016/j.ejmech.2009.11.023
BindingDB Entry DOI: 10.7270/Q2445MJR
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50300166
PNG
(CHEMBL566533 | Ethyl 5-(3-(4-(3-chlorophenyl)piper...)
Show SMILES CCOC(=O)c1cc2cc(OCCCN3CCN(CC3)c3cccc(Cl)c3)ccc2[nH]1
Show InChI InChI=1S/C24H28ClN3O3/c1-2-30-24(29)23-16-18-15-21(7-8-22(18)26-23)31-14-4-9-27-10-12-28(13-11-27)20-6-3-5-19(25)17-20/h3,5-8,15-17,26H,2,4,9-14H2,1H3
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 1.00E+4n/an/an/an/an/an/an/an/a



Universit£ di Napoli

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5HT2A in Sprague-Dawley rat brain cortex by liquid scintillation counting

Eur J Med Chem 45: 752-9 (2010)


Article DOI: 10.1016/j.ejmech.2009.11.023
BindingDB Entry DOI: 10.7270/Q2445MJR
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50300159
PNG
(CHEMBL583422 | Ethyl 5-(3-(4-((benzo[d][1,3]dioxol...)
Show SMILES CCOC(=O)c1cc2cc(OCCCN3CCN(Cc4ccc5OCOc5c4)CC3)ccc2[nH]1
Show InChI InChI=1S/C26H31N3O5/c1-2-31-26(30)23-16-20-15-21(5-6-22(20)27-23)32-13-3-8-28-9-11-29(12-10-28)17-19-4-7-24-25(14-19)34-18-33-24/h4-7,14-16,27H,2-3,8-13,17-18H2,1H3
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 1.00E+4n/an/an/an/an/an/an/an/a



Universit£ di Napoli

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from dopamine D1 in rat striatum by liquid scintillation counting

Eur J Med Chem 45: 752-9 (2010)


Article DOI: 10.1016/j.ejmech.2009.11.023
BindingDB Entry DOI: 10.7270/Q2445MJR
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50300161
PNG
(CHEMBL568285 | ethyl 5-(3-(4-(3,4-dichlorophenyl)p...)
Show SMILES CCOC(=O)c1cc2cc(OCCCN3CCN(CC3)c3ccc(Cl)c(Cl)c3)ccc2[nH]1
Show InChI InChI=1S/C24H27Cl2N3O3/c1-2-31-24(30)23-15-17-14-19(5-7-22(17)27-23)32-13-3-8-28-9-11-29(12-10-28)18-4-6-20(25)21(26)16-18/h4-7,14-16,27H,2-3,8-13H2,1H3
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 1.00E+4n/an/an/an/an/an/an/an/a



Universit£ di Napoli

Curated by ChEMBL


Assay Description
Displacement of [3H]8OH-DPAT from 5HT1A in Sprague-Dawley rat brain cortex by liquid scintillation counting

Eur J Med Chem 45: 752-9 (2010)


Article DOI: 10.1016/j.ejmech.2009.11.023
BindingDB Entry DOI: 10.7270/Q2445MJR
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50300163
PNG
(CHEMBL567834 | Ethyl 5-(3-(4-(2-cyanophenyl)pipera...)
Show SMILES CCOC(=O)c1cc2cc(OCCCN3CCN(CC3)c3ccccc3C#N)ccc2[nH]1
Show InChI InChI=1S/C25H28N4O3/c1-2-31-25(30)23-17-20-16-21(8-9-22(20)27-23)32-15-5-10-28-11-13-29(14-12-28)24-7-4-3-6-19(24)18-26/h3-4,6-9,16-17,27H,2,5,10-15H2,1H3
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 1.00E+4n/an/an/an/an/an/an/an/a



Universit£ di Napoli

Curated by ChEMBL


Assay Description
Displacement of [3H]8OH-DPAT from 5HT1A in Sprague-Dawley rat brain cortex by liquid scintillation counting

Eur J Med Chem 45: 752-9 (2010)


Article DOI: 10.1016/j.ejmech.2009.11.023
BindingDB Entry DOI: 10.7270/Q2445MJR
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50300170
PNG
(CHEMBL568284 | Ethyl 5-(3-(4-(4-chlorophenyl)piper...)
Show SMILES CCOC(=O)c1cc2cc(OCCCN3CCN(CC3)c3ccc(Cl)cc3)ccc2[nH]1
Show InChI InChI=1S/C24H28ClN3O3/c1-2-30-24(29)23-17-18-16-21(8-9-22(18)26-23)31-15-3-10-27-11-13-28(14-12-27)20-6-4-19(25)5-7-20/h4-9,16-17,26H,2-3,10-15H2,1H3
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 1.00E+4n/an/an/an/an/an/an/an/a



Universit£ di Napoli

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5HT2A in Sprague-Dawley rat brain cortex by liquid scintillation counting

Eur J Med Chem 45: 752-9 (2010)


Article DOI: 10.1016/j.ejmech.2009.11.023
BindingDB Entry DOI: 10.7270/Q2445MJR
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50300160
PNG
(CHEMBL565707 | Ethyl 5-(3-(4-(4-methoxyphenyl)pipe...)
Show SMILES CCOC(=O)c1cc2cc(OCCCN3CCN(CC3)c3ccc(OC)cc3)ccc2[nH]1
Show InChI InChI=1S/C25H31N3O4/c1-3-31-25(29)24-18-19-17-22(9-10-23(19)26-24)32-16-4-11-27-12-14-28(15-13-27)20-5-7-21(30-2)8-6-20/h5-10,17-18,26H,3-4,11-16H2,1-2H3
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 1.00E+4n/an/an/an/an/an/an/an/a



Universit£ di Napoli

Curated by ChEMBL


Assay Description
Displacement of [3H]8OH-DPAT from 5HT1A in Sprague-Dawley rat brain cortex by liquid scintillation counting

Eur J Med Chem 45: 752-9 (2010)


Article DOI: 10.1016/j.ejmech.2009.11.023
BindingDB Entry DOI: 10.7270/Q2445MJR
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50300162
PNG
(CHEMBL586050 | Ethyl 5-(3-(4-(2-chlorophenyl)piper...)
Show SMILES CCOC(=O)c1cc2cc(OCCCN3CCN(CC3)c3ccccc3Cl)ccc2[nH]1
Show InChI InChI=1S/C24H28ClN3O3/c1-2-30-24(29)22-17-18-16-19(8-9-21(18)26-22)31-15-5-10-27-11-13-28(14-12-27)23-7-4-3-6-20(23)25/h3-4,6-9,16-17,26H,2,5,10-15H2,1H3
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 1.00E+4n/an/an/an/an/an/an/an/a



Universit£ di Napoli

Curated by ChEMBL


Assay Description
Displacement of [3H]8OH-DPAT from 5HT1A in Sprague-Dawley rat brain cortex by liquid scintillation counting

Eur J Med Chem 45: 752-9 (2010)


Article DOI: 10.1016/j.ejmech.2009.11.023
BindingDB Entry DOI: 10.7270/Q2445MJR
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50300161
PNG
(CHEMBL568285 | ethyl 5-(3-(4-(3,4-dichlorophenyl)p...)
Show SMILES CCOC(=O)c1cc2cc(OCCCN3CCN(CC3)c3ccc(Cl)c(Cl)c3)ccc2[nH]1
Show InChI InChI=1S/C24H27Cl2N3O3/c1-2-31-24(30)23-15-17-14-19(5-7-22(17)27-23)32-13-3-8-28-9-11-29(12-10-28)18-4-6-20(25)21(26)16-18/h4-7,14-16,27H,2-3,8-13H2,1H3
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 1.00E+4n/an/an/an/an/an/an/an/a



Universit£ di Napoli

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine from 5HT2C in Sprague-Dawley rat brain cortex by liquid scintillation counting

Eur J Med Chem 45: 752-9 (2010)


Article DOI: 10.1016/j.ejmech.2009.11.023
BindingDB Entry DOI: 10.7270/Q2445MJR
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50300160
PNG
(CHEMBL565707 | Ethyl 5-(3-(4-(4-methoxyphenyl)pipe...)
Show SMILES CCOC(=O)c1cc2cc(OCCCN3CCN(CC3)c3ccc(OC)cc3)ccc2[nH]1
Show InChI InChI=1S/C25H31N3O4/c1-3-31-25(29)24-18-19-17-22(9-10-23(19)26-24)32-16-4-11-27-12-14-28(15-13-27)20-5-7-21(30-2)8-6-20/h5-10,17-18,26H,3-4,11-16H2,1-2H3
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 1.00E+4n/an/an/an/an/an/an/an/a



Universit£ di Napoli

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5HT2A in Sprague-Dawley rat brain cortex by liquid scintillation counting

Eur J Med Chem 45: 752-9 (2010)


Article DOI: 10.1016/j.ejmech.2009.11.023
BindingDB Entry DOI: 10.7270/Q2445MJR
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50300164
PNG
(CHEMBL567648 | Ethyl 5-(3-(4-o-tolylpiperazin-1-yl...)
Show SMILES CCOC(=O)c1cc2cc(OCCCN3CCN(CC3)c3ccccc3C)ccc2[nH]1
Show InChI InChI=1S/C25H31N3O3/c1-3-30-25(29)23-18-20-17-21(9-10-22(20)26-23)31-16-6-11-27-12-14-28(15-13-27)24-8-5-4-7-19(24)2/h4-5,7-10,17-18,26H,3,6,11-16H2,1-2H3
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 1.00E+4n/an/an/an/an/an/an/an/a



Universit£ di Napoli

Curated by ChEMBL


Assay Description
Displacement of [3H]8OH-DPAT from 5HT1A in Sprague-Dawley rat brain cortex by liquid scintillation counting

Eur J Med Chem 45: 752-9 (2010)


Article DOI: 10.1016/j.ejmech.2009.11.023
BindingDB Entry DOI: 10.7270/Q2445MJR
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%