BindingDB logo
myBDB logout

PubMed code 20007017

Compile data set for download or QSAR
Found 45 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306179
PNG
(5-fluoro-2-(4-((methylamino)methyl)phenyl)-2H-inda...)
Show SMILES CNCc1ccc(cc1)-n1cc2cc(F)cc(C(N)=O)c2n1
Show InChI InChI=1S/C16H15FN4O/c1-19-8-10-2-4-13(5-3-10)21-9-11-6-12(17)7-14(16(18)22)15(11)20-21/h2-7,9,19H,8H2,1H3,(H2,18,22)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.40n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306173
PNG
(5-fluoro-2-(3-fluoro-4-((methylamino)methyl)phenyl...)
Show SMILES CNCc1ccc(cc1F)-n1cc2cc(F)cc(C(N)=O)c2n1
Show InChI InChI=1S/C16H14F2N4O/c1-20-7-9-2-3-12(6-14(9)18)22-8-10-4-11(17)5-13(16(19)23)15(10)21-22/h2-6,8,20H,7H2,1H3,(H2,19,23)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306168
PNG
(2-(4-(azetidine-3-carboxamido)-3-fluorophenyl)-5-f...)
Show SMILES NC(=O)c1cc(F)cc2cn(nc12)-c1ccc(NC(=O)C2CNC2)c(F)c1
Show InChI InChI=1S/C18H15F2N5O2/c19-11-3-9-8-25(24-16(9)13(4-11)17(21)26)12-1-2-15(14(20)5-12)23-18(27)10-6-22-7-10/h1-5,8,10,22H,6-7H2,(H2,21,26)(H,23,27)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 4n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306186
PNG
(2-(3-methoxy-4-((methylamino)methyl)phenyl)-2H-ind...)
Show SMILES CNCc1ccc(cc1OC)-n1cc2cccc(C(N)=O)c2n1
Show InChI InChI=1S/C17H18N4O2/c1-19-9-11-6-7-13(8-15(11)23-2)21-10-12-4-3-5-14(17(18)22)16(12)20-21/h3-8,10,19H,9H2,1-2H3,(H2,18,22)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 4n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306184
PNG
(2-(3-fluoro-4-((methylamino)methyl)phenyl)-2H-inda...)
Show SMILES CNCc1ccc(cc1F)-n1cc2cccc(C(N)=O)c2n1
Show InChI InChI=1S/C16H15FN4O/c1-19-8-10-5-6-12(7-14(10)17)21-9-11-3-2-4-13(16(18)22)15(11)20-21/h2-7,9,19H,8H2,1H3,(H2,18,22)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 4n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306187
PNG
(2-(4-((methylamino)methyl)-3-(trifluoromethyl)phen...)
Show SMILES CNCc1ccc(cc1C(F)(F)F)-n1cc2cccc(C(N)=O)c2n1
Show InChI InChI=1S/C17H15F3N4O/c1-22-8-10-5-6-12(7-14(10)17(18,19)20)24-9-11-3-2-4-13(16(21)25)15(11)23-24/h2-7,9,22H,8H2,1H3,(H2,21,25)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 5n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306181
PNG
(5-chloro-2-(4-((methylamino)methyl)phenyl)-2H-inda...)
Show SMILES CNCc1ccc(cc1)-n1cc2cc(Cl)cc(C(N)=O)c2n1
Show InChI InChI=1S/C16H15ClN4O/c1-19-8-10-2-4-13(5-3-10)21-9-11-6-12(17)7-14(16(18)22)15(11)20-21/h2-7,9,19H,8H2,1H3,(H2,18,22)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 5n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306171
PNG
(2-(4-(azetidine-3-carboxamido)phenyl)-5-fluoro-2H-...)
Show SMILES NC(=O)c1cc(F)cc2cn(nc12)-c1ccc(NC(=O)C2CNC2)cc1
Show InChI InChI=1S/C18H16FN5O2/c19-12-5-10-9-24(23-16(10)15(6-12)17(20)25)14-3-1-13(2-4-14)22-18(26)11-7-21-8-11/h1-6,9,11,21H,7-8H2,(H2,20,25)(H,22,26)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 5n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306210
PNG
(2-(4-((methylamino)methyl)phenyl)-2H-indazole-7-ca...)
Show SMILES CNCc1ccc(cc1)-n1cc2cccc(C(N)=O)c2n1
Show InChI InChI=1S/C16H16N4O/c1-18-9-11-5-7-13(8-6-11)20-10-12-3-2-4-14(16(17)21)15(12)19-20/h2-8,10,18H,9H2,1H3,(H2,17,21)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 5n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306167
PNG
(5-fluoro-2-(3-fluoro-4-(1-methylazetidine-3-carbox...)
Show SMILES CN1CC(C1)C(=O)Nc1ccc(cc1F)-n1cc2cc(F)cc(C(N)=O)c2n1
Show InChI InChI=1S/C19H17F2N5O2/c1-25-7-11(8-25)19(28)23-16-3-2-13(6-15(16)21)26-9-10-4-12(20)5-14(18(22)27)17(10)24-26/h2-6,9,11H,7-8H2,1H3,(H2,22,27)(H,23,28)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 6n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306174
PNG
(5-fluoro-2-(2-fluoro-4-((methylamino)methyl)phenyl...)
Show SMILES CNCc1ccc(c(F)c1)-n1cc2cc(F)cc(C(N)=O)c2n1
Show InChI InChI=1S/C16H14F2N4O/c1-20-7-9-2-3-14(13(18)4-9)22-8-10-5-11(17)6-12(16(19)23)15(10)21-22/h2-6,8,20H,7H2,1H3,(H2,19,23)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 6n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306170
PNG
(5-fluoro-2-(4-(1-methylazetidine-3-carboxamido)phe...)
Show SMILES CN1CC(C1)C(=O)Nc1ccc(cc1)-n1cc2cc(F)cc(C(N)=O)c2n1
Show InChI InChI=1S/C19H18FN5O2/c1-24-8-12(9-24)19(27)22-14-2-4-15(5-3-14)25-10-11-6-13(20)7-16(18(21)26)17(11)23-25/h2-7,10,12H,8-9H2,1H3,(H2,21,26)(H,22,27)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 6n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306180
PNG
(4-fluoro-2-(4-((methylamino)methyl)phenyl)-2H-inda...)
Show SMILES CNCc1ccc(cc1)-n1cc2c(F)ccc(C(N)=O)c2n1
Show InChI InChI=1S/C16H15FN4O/c1-19-8-10-2-4-11(5-3-10)21-9-13-14(17)7-6-12(16(18)22)15(13)20-21/h2-7,9,19H,8H2,1H3,(H2,18,22)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 8n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306205
PNG
(2-(4-(pyridin-4-ylmethylcarbamoyl)phenyl)-2H-indaz...)
Show SMILES NC(=O)c1cccc2cn(nc12)-c1ccc(cc1)C(=O)NCc1ccncc1
Show InChI InChI=1S/C21H17N5O2/c22-20(27)18-3-1-2-16-13-26(25-19(16)18)17-6-4-15(5-7-17)21(28)24-12-14-8-10-23-11-9-14/h1-11,13H,12H2,(H2,22,27)(H,24,28)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 10n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306200
PNG
(2-(4-(2-(pyrrolidin-1-yl)acetamido)phenyl)-2H-inda...)
Show SMILES NC(=O)c1cccc2cn(nc12)-c1ccc(NC(=O)CN2CCCC2)cc1
Show InChI InChI=1S/C20H21N5O2/c21-20(27)17-5-3-4-14-12-25(23-19(14)17)16-8-6-15(7-9-16)22-18(26)13-24-10-1-2-11-24/h3-9,12H,1-2,10-11,13H2,(H2,21,27)(H,22,26)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 10n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306192
PNG
(2-(4-(azetidine-3-carboxamido)phenyl)-2H-indazole-...)
Show SMILES NC(=O)c1cccc2cn(nc12)-c1ccc(NC(=O)C2CNC2)cc1
Show InChI InChI=1S/C18H17N5O2/c19-17(24)15-3-1-2-11-10-23(22-16(11)15)14-6-4-13(5-7-14)21-18(25)12-8-20-9-12/h1-7,10,12,20H,8-9H2,(H2,19,24)(H,21,25)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 10n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306209
PNG
(2-(4-(2-(dimethylamino)ethylcarbamoyl)phenyl)-2H-i...)
Show SMILES CN(C)CCNC(=O)c1ccc(cc1)-n1cc2cccc(C(N)=O)c2n1
Show InChI InChI=1S/C19H21N5O2/c1-23(2)11-10-21-19(26)13-6-8-15(9-7-13)24-12-14-4-3-5-16(18(20)25)17(14)22-24/h3-9,12H,10-11H2,1-2H3,(H2,20,25)(H,21,26)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 10n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306196
PNG
(2-(4-(1-methylpiperidine-4-carboxamido)phenyl)-2H-...)
Show SMILES CN1CCC(CC1)C(=O)Nc1ccc(cc1)-n1cc2cccc(C(N)=O)c2n1
Show InChI InChI=1S/C21H23N5O2/c1-25-11-9-14(10-12-25)21(28)23-16-5-7-17(8-6-16)26-13-15-3-2-4-18(20(22)27)19(15)24-26/h2-8,13-14H,9-12H2,1H3,(H2,22,27)(H,23,28)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 10n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306169
PNG
((R)-5-fluoro-2-(3-fluoro-4-(1-methylpiperidine-3-c...)
Show SMILES CN1CCC[C@H](C1)C(=O)Nc1ccc(cc1F)-n1cc2cc(F)cc(C(N)=O)c2n1 |r|
Show InChI InChI=1S/C21H21F2N5O2/c1-27-6-2-3-12(10-27)21(30)25-18-5-4-15(9-17(18)23)28-11-13-7-14(22)8-16(20(24)29)19(13)26-28/h4-5,7-9,11-12H,2-3,6,10H2,1H3,(H2,24,29)(H,25,30)/t12-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 12n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306185
PNG
(2-(3-hydroxy-4-((methylamino)methyl)phenyl)-2H-ind...)
Show SMILES CNCc1ccc(cc1O)-n1cc2cccc(C(N)=O)c2n1
Show InChI InChI=1S/C16H16N4O2/c1-18-8-10-5-6-12(7-14(10)21)20-9-11-3-2-4-13(16(17)22)15(11)19-20/h2-7,9,18,21H,8H2,1H3,(H2,17,22)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 12n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306201
PNG
(2-(4-(2-(dimethylamino)acetamido)phenyl)-2H-indazo...)
Show SMILES CN(C)CC(=O)Nc1ccc(cc1)-n1cc2cccc(C(N)=O)c2n1
Show InChI InChI=1S/C18H19N5O2/c1-22(2)11-16(24)20-13-6-8-14(9-7-13)23-10-12-4-3-5-15(18(19)25)17(12)21-23/h3-10H,11H2,1-2H3,(H2,19,25)(H,20,24)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 15n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306172
PNG
(5-fluoro-2-(4-(1-methylpiperidine-4-carboxamido)ph...)
Show SMILES CN1CCC(CC1)C(=O)Nc1ccc(cc1)-n1cc2cc(F)cc(C(N)=O)c2n1
Show InChI InChI=1S/C21H22FN5O2/c1-26-8-6-13(7-9-26)21(29)24-16-2-4-17(5-3-16)27-12-14-10-15(22)11-18(20(23)28)19(14)25-27/h2-5,10-13H,6-9H2,1H3,(H2,23,28)(H,24,29)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 16n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306193
PNG
((S)-2-(4-(1-methylpyrrolidine-2-carboxamido)phenyl...)
Show SMILES CN1CCC[C@H]1C(=O)Nc1ccc(cc1)-n1cc2cccc(C(N)=O)c2n1 |r|
Show InChI InChI=1S/C20H21N5O2/c1-24-11-3-6-17(24)20(27)22-14-7-9-15(10-8-14)25-12-13-4-2-5-16(19(21)26)18(13)23-25/h2,4-5,7-10,12,17H,3,6,11H2,1H3,(H2,21,26)(H,22,27)/t17-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 17n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306190
PNG
(2-(4-((N-methylazetidine-3-carboxamido)methyl)phen...)
Show SMILES CN(Cc1ccc(cc1)-n1cc2cccc(C(N)=O)c2n1)C(=O)C1CNC1
Show InChI InChI=1S/C20H21N5O2/c1-24(20(27)15-9-22-10-15)11-13-5-7-16(8-6-13)25-12-14-3-2-4-17(19(21)26)18(14)23-25/h2-8,12,15,22H,9-11H2,1H3,(H2,21,26)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 18n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306199
PNG
(2-(4-(2-(piperidin-1-yl)acetamido)phenyl)-2H-indaz...)
Show SMILES NC(=O)c1cccc2cn(nc12)-c1ccc(NC(=O)CN2CCCCC2)cc1
Show InChI InChI=1S/C21H23N5O2/c22-21(28)18-6-4-5-15-13-26(24-20(15)18)17-9-7-16(8-10-17)23-19(27)14-25-11-2-1-3-12-25/h4-10,13H,1-3,11-12,14H2,(H2,22,28)(H,23,27)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 20n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306183
PNG
(3-chloro-2-(4-((methylamino)methyl)phenyl)-2H-inda...)
Show SMILES CNCc1ccc(cc1)-n1nc2c(cccc2c1Cl)C(N)=O
Show InChI InChI=1S/C16H15ClN4O/c1-19-9-10-5-7-11(8-6-10)21-15(17)12-3-2-4-13(16(18)22)14(12)20-21/h2-8,19H,9H2,1H3,(H2,18,22)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 20n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306194
PNG
((S)-2-(4-(1-methylpiperidine-3-carboxamido)phenyl)...)
Show SMILES CN1CCC[C@@H](C1)C(=O)Nc1ccc(cc1)-n1cc2cccc(C(N)=O)c2n1 |r|
Show InChI InChI=1S/C21H23N5O2/c1-25-11-3-5-15(12-25)21(28)23-16-7-9-17(10-8-16)26-13-14-4-2-6-18(20(22)27)19(14)24-26/h2,4,6-10,13,15H,3,5,11-12H2,1H3,(H2,22,27)(H,23,28)/t15-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 20n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306208
PNG
(2-(4-(2-(pyrrolidin-1-yl)ethylcarbamoyl)phenyl)-2H...)
Show SMILES NC(=O)c1cccc2cn(nc12)-c1ccc(cc1)C(=O)NCCN1CCCC1
Show InChI InChI=1S/C21H23N5O2/c22-20(27)18-5-3-4-16-14-26(24-19(16)18)17-8-6-15(7-9-17)21(28)23-10-13-25-11-1-2-12-25/h3-9,14H,1-2,10-13H2,(H2,22,27)(H,23,28)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 20n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306178
PNG
(6-fluoro-2-(4-((methylamino)methyl)phenyl)-2H-inda...)
Show SMILES CNCc1ccc(cc1)-n1cc2ccc(F)c(C(N)=O)c2n1
Show InChI InChI=1S/C16H15FN4O/c1-19-8-10-2-5-12(6-3-10)21-9-11-4-7-13(17)14(16(18)22)15(11)20-21/h2-7,9,19H,8H2,1H3,(H2,18,22)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 20n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306203
PNG
(2-(4-(1,4-diazepane-1-carbonyl)phenyl)-2H-indazole...)
Show SMILES NC(=O)c1cccc2cn(nc12)-c1ccc(cc1)C(=O)N1CCCNCC1
Show InChI InChI=1S/C20H21N5O2/c21-19(26)17-4-1-3-15-13-25(23-18(15)17)16-7-5-14(6-8-16)20(27)24-11-2-9-22-10-12-24/h1,3-8,13,22H,2,9-12H2,(H2,21,26)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 22n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306189
PNG
(2-(4-((1-methylpiperidine-3-carboxamido)methyl)phe...)
Show SMILES CN1CCCC(C1)C(=O)NCc1ccc(cc1)-n1cc2cccc(C(N)=O)c2n1
Show InChI InChI=1S/C22H25N5O2/c1-26-11-3-5-17(13-26)22(29)24-12-15-7-9-18(10-8-15)27-14-16-4-2-6-19(21(23)28)20(16)25-27/h2,4,6-10,14,17H,3,5,11-13H2,1H3,(H2,23,28)(H,24,29)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 22n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306166
PNG
(2-phenyl-2H-indazole-7-carboxamide | CHEMBL594298)
Show SMILES NC(=O)c1cccc2cn(nc12)-c1ccccc1
Show InChI InChI=1S/C14H11N3O/c15-14(18)12-8-4-5-10-9-17(16-13(10)12)11-6-2-1-3-7-11/h1-9H,(H2,15,18)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 25n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306191
PNG
(2-(4-((N,1-dimethylpiperidine-3-carboxamido)methyl...)
Show SMILES CN(Cc1ccc(cc1)-n1cc2cccc(C(N)=O)c2n1)C(=O)C1CCCN(C)C1
Show InChI InChI=1S/C23H27N5O2/c1-26-12-4-6-18(14-26)23(30)27(2)13-16-8-10-19(11-9-16)28-15-17-5-3-7-20(22(24)29)21(17)25-28/h3,5,7-11,15,18H,4,6,12-14H2,1-2H3,(H2,24,29)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 25n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306177
PNG
(4,5-difluoro-2-(4-((methylamino)methyl)phenyl)-2H-...)
Show SMILES CNCc1ccc(cc1)-n1cc2c(F)c(F)cc(C(N)=O)c2n1
Show InChI InChI=1S/C16H14F2N4O/c1-20-7-9-2-4-10(5-3-9)22-8-12-14(18)13(17)6-11(16(19)23)15(12)21-22/h2-6,8,20H,7H2,1H3,(H2,19,23)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 25n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306198
PNG
(2-(4-(2-morpholinoacetamido)phenyl)-2H-indazole-7-...)
Show SMILES NC(=O)c1cccc2cn(nc12)-c1ccc(NC(=O)CN2CCOCC2)cc1
Show InChI InChI=1S/C20H21N5O3/c21-20(27)17-3-1-2-14-12-25(23-19(14)17)16-6-4-15(5-7-16)22-18(26)13-24-8-10-28-11-9-24/h1-7,12H,8-11,13H2,(H2,21,27)(H,22,26)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 30n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306195
PNG
((R)-2-(4-(1-methylpiperidine-3-carboxamido)phenyl)...)
Show SMILES CN1CCC[C@H](C1)C(=O)Nc1ccc(cc1)-n1cc2cccc(C(N)=O)c2n1 |r|
Show InChI InChI=1S/C21H23N5O2/c1-25-11-3-5-15(12-25)21(28)23-16-7-9-17(10-8-16)26-13-14-4-2-6-18(20(22)27)19(14)24-26/h2,4,6-10,13,15H,3,5,11-12H2,1H3,(H2,22,27)(H,23,28)/t15-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 30n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306204
PNG
(2-(4-(pyridin-4-ylcarbamoyl)phenyl)-2H-indazole-7-...)
Show SMILES NC(=O)c1cccc2cn(nc12)-c1ccc(cc1)C(=O)Nc1ccncc1
Show InChI InChI=1S/C20H15N5O2/c21-19(26)17-3-1-2-14-12-25(24-18(14)17)16-6-4-13(5-7-16)20(27)23-15-8-10-22-11-9-15/h1-12H,(H2,21,26)(H,22,23,27)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 30n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306207
PNG
(2-(4-(2-(piperidin-1-yl)ethylcarbamoyl)phenyl)-2H-...)
Show SMILES NC(=O)c1cccc2cn(nc12)-c1ccc(cc1)C(=O)NCCN1CCCCC1
Show InChI InChI=1S/C22H25N5O2/c23-21(28)19-6-4-5-17-15-27(25-20(17)19)18-9-7-16(8-10-18)22(29)24-11-14-26-12-2-1-3-13-26/h4-10,15H,1-3,11-14H2,(H2,23,28)(H,24,29)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 38n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306202
PNG
(2-(3-(1,4-diazepane-1-carbonyl)phenyl)-2H-indazole...)
Show SMILES NC(=O)c1cccc2cn(nc12)-c1cccc(c1)C(=O)N1CCCNCC1
Show InChI InChI=1S/C20H21N5O2/c21-19(26)17-7-2-5-15-13-25(23-18(15)17)16-6-1-4-14(12-16)20(27)24-10-3-8-22-9-11-24/h1-2,4-7,12-13,22H,3,8-11H2,(H2,21,26)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 40n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306197
PNG
((+/-)-2-(4-(1-methylpiperidine-2-carboxamido)pheny...)
Show SMILES CN1CCCCC1C(=O)Nc1ccc(cc1)-n1cc2cccc(C(N)=O)c2n1
Show InChI InChI=1S/C21H23N5O2/c1-25-12-3-2-7-18(25)21(28)23-15-8-10-16(11-9-15)26-13-14-5-4-6-17(20(22)27)19(14)24-26/h4-6,8-11,13,18H,2-3,7,12H2,1H3,(H2,22,27)(H,23,28)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 46n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306206
PNG
(2-(4-(2-morpholinoethylcarbamoyl)phenyl)-2H-indazo...)
Show SMILES NC(=O)c1cccc2cn(nc12)-c1ccc(cc1)C(=O)NCCN1CCOCC1
Show InChI InChI=1S/C21H23N5O3/c22-20(27)18-3-1-2-16-14-26(24-19(16)18)17-6-4-15(5-7-17)21(28)23-8-9-25-10-12-29-13-11-25/h1-7,14H,8-13H2,(H2,22,27)(H,23,28)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 54n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306188
PNG
(2-(4-((azetidine-3-carboxamido)methyl)phenyl)-2H-i...)
Show SMILES NC(=O)c1cccc2cn(nc12)-c1ccc(CNC(=O)C2CNC2)cc1
Show InChI InChI=1S/C19H19N5O2/c20-18(25)16-3-1-2-13-11-24(23-17(13)16)15-6-4-12(5-7-15)8-22-19(26)14-9-21-10-14/h1-7,11,14,21H,8-10H2,(H2,20,25)(H,22,26)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 65n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306182
PNG
(4-chloro-2-(4-((methylamino)methyl)phenyl)-2H-inda...)
Show SMILES CNCc1ccc(cc1)-n1cc2c(Cl)ccc(C(N)=O)c2n1
Show InChI InChI=1S/C16H15ClN4O/c1-19-8-10-2-4-11(5-3-10)21-9-13-14(17)7-6-12(16(18)22)15(13)20-21/h2-7,9,19H,8H2,1H3,(H2,18,22)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 180n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306175
PNG
(4-hydroxy-2-(4-((methylamino)methyl)phenyl)-2H-ind...)
Show SMILES CNCc1ccc(cc1)-n1cc2c(O)ccc(C(N)=O)c2n1
Show InChI InChI=1S/C16H16N4O2/c1-18-8-10-2-4-11(5-3-10)20-9-13-14(21)7-6-12(16(17)22)15(13)19-20/h2-7,9,18,21H,8H2,1H3,(H2,17,22)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 540n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306176
PNG
(4-methoxy-2-(4-((methylamino)methyl)phenyl)-2H-ind...)
Show SMILES CNCc1ccc(cc1)-n1cc2c(OC)ccc(C(N)=O)c2n1
Show InChI InChI=1S/C17H18N4O2/c1-19-9-11-3-5-12(6-4-11)21-10-14-15(23-2)8-7-13(17(18)22)16(14)20-21/h3-8,10,19H,9H2,1-2H3,(H2,18,22)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%