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PubMed code 2002463

Compile data set for download or QSAR
Found 78 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011635
PNG
(1-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCN1C(=O)CCc2ccccc12)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C27H20ClN5OS/c1-17-30-31-24-16-29-26(20-9-3-4-10-22(20)28)21-15-19(35-27(21)33(17)24)8-6-14-32-23-11-5-2-7-18(23)12-13-25(32)34/h2-5,7,9-11,15H,12-14,16H2,1H3
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n/an/a 0.200n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011650
PNG
(1-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCn1c2ccccc2n(C)c1=O)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C26H19ClN6OS/c1-16-29-30-23-15-28-24(18-9-3-4-10-20(18)27)19-14-17(35-25(19)33(16)23)8-7-13-32-22-12-6-5-11-21(22)31(2)26(32)34/h3-6,9-12,14H,13,15H2,1-2H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011611
PNG
(1-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCn1c2ccccc2c(=O)n(C)c1=O)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C27H19ClN6O2S/c1-16-30-31-23-15-29-24(18-9-3-5-11-21(18)28)20-14-17(37-26(20)34(16)23)8-7-13-33-22-12-6-4-10-19(22)25(35)32(2)27(33)36/h3-6,9-12,14H,13,15H2,1-2H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011634
PNG
(4-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCN1C(=O)COc2ccccc12)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C26H18ClN5O2S/c1-16-29-30-23-14-28-25(18-8-2-3-9-20(18)27)19-13-17(35-26(19)32(16)23)7-6-12-31-21-10-4-5-11-22(21)34-15-24(31)33/h2-5,8-11,13H,12,14-15H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011623
PNG
(2a-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCC12CCCc3cccc(NC1=O)c23)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C29H22ClN5OS/c1-17-33-34-24-16-31-26(20-10-2-3-11-22(20)30)21-15-19(37-27(21)35(17)24)9-6-14-29-13-5-8-18-7-4-12-23(25(18)29)32-28(29)36/h2-4,7,10-12,15H,5,8,13-14,16H2,1H3,(H,32,36)
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011603
PNG
(1-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCn1c2ccccc2n(-c2ccccc2)c1=O)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C31H21ClN6OS/c1-20-34-35-28-19-33-29(23-13-5-6-14-25(23)32)24-18-22(40-30(24)37(20)28)12-9-17-36-26-15-7-8-16-27(26)38(31(36)39)21-10-3-2-4-11-21/h2-8,10-11,13-16,18H,17,19H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011640
PNG
(4-(2-Chloro-phenyl)-2-(3-indazol-1-yl-prop-1-ynyl)...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCn1ncc2ccccc12)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C25H17ClN6S/c1-16-29-30-23-15-27-24(19-9-3-4-10-21(19)26)20-13-18(33-25(20)32(16)23)8-6-12-31-22-11-5-2-7-17(22)14-28-31/h2-5,7,9-11,13-14H,12,15H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011653
PNG
(2-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCn1ccc2ccccc2c1=O)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C27H18ClN5OS/c1-17-30-31-24-16-29-25(21-10-4-5-11-23(21)28)22-15-19(35-27(22)33(17)24)8-6-13-32-14-12-18-7-2-3-9-20(18)26(32)34/h2-5,7,9-12,14-15H,13,16H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011669
PNG
(1-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCn1c2ccccc2ccc1=O)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C27H18ClN5OS/c1-17-30-31-24-16-29-26(20-9-3-4-10-22(20)28)21-15-19(35-27(21)33(17)24)8-6-14-32-23-11-5-2-7-18(23)12-13-25(32)34/h2-5,7,9-13,15H,14,16H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011673
PNG
(4-(2-Chloro-phenyl)-9-methyl-2-(3-phenoxy-prop-1-y...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCOc1ccccc1)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C24H17ClN4OS/c1-16-27-28-22-15-26-23(19-11-5-6-12-21(19)25)20-14-18(31-24(20)29(16)22)10-7-13-30-17-8-3-2-4-9-17/h2-6,8-9,11-12,14H,13,15H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011663
PNG
(1-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCN1C(=O)Cc2ccccc12)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C26H18ClN5OS/c1-16-29-30-23-15-28-25(19-9-3-4-10-21(19)27)20-14-18(34-26(20)32(16)23)8-6-12-31-22-11-5-2-7-17(22)13-24(31)33/h2-5,7,9-11,14H,12-13,15H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011646
PNG
(1-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCN1C(=O)OCc2ccccc12)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C26H18ClN5O2S/c1-16-29-30-23-14-28-24(19-9-3-4-10-21(19)27)20-13-18(35-25(20)32(16)23)8-6-12-31-22-11-5-2-7-17(22)15-34-26(31)33/h2-5,7,9-11,13H,12,14-15H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011602
PNG
(2-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCN1Cc2cccc3cccc(C1=O)c23)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C30H20ClN5OS/c1-18-33-34-26-16-32-28(22-11-2-3-13-25(22)31)24-15-21(38-30(24)36(18)26)10-6-14-35-17-20-9-4-7-19-8-5-12-23(27(19)20)29(35)37/h2-5,7-9,11-13,15H,14,16-17H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011649
PNG
(4-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCN1C(=O)COc2cc(F)ccc12)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C26H17ClFN5O2S/c1-15-30-31-23-13-29-25(18-6-2-3-7-20(18)27)19-12-17(36-26(19)33(15)23)5-4-10-32-21-9-8-16(28)11-22(21)35-14-24(32)34/h2-3,6-9,11-12H,10,13-14H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011627
PNG
(4-(2-Chloro-phenyl)-9-methyl-2-[3-(pyridin-3-yloxy...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCOc1cccnc1)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C23H16ClN5OS/c1-15-27-28-21-14-26-22(18-8-2-3-9-20(18)24)19-12-17(31-23(19)29(15)21)7-5-11-30-16-6-4-10-25-13-16/h2-4,6,8-10,12-13H,11,14H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011655
PNG
(6-Chloro-4-{3-[4-(2-chloro-phenyl)-9-methyl-6H-1-t...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCN1C(=O)COc2ccc(Cl)cc12)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C26H17Cl2N5O2S/c1-15-30-31-23-13-29-25(18-6-2-3-7-20(18)28)19-12-17(36-26(19)33(15)23)5-4-10-32-21-11-16(27)8-9-22(21)35-14-24(32)34/h2-3,6-9,11-12H,10,13-14H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011661
PNG
(2-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCN1CCc2ccccc2C1=O)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C27H20ClN5OS/c1-17-30-31-24-16-29-25(21-10-4-5-11-23(21)28)22-15-19(35-27(22)33(17)24)8-6-13-32-14-12-18-7-2-3-9-20(18)26(32)34/h2-5,7,9-11,15H,12-14,16H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011666
PNG
(1-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCN1C(=O)c2cccc3cccc1c23)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C29H18ClN5OS/c1-17-32-33-25-16-31-27(20-10-2-3-12-23(20)30)22-15-19(37-29(22)35(17)25)9-6-14-34-24-13-5-8-18-7-4-11-21(26(18)24)28(34)36/h2-5,7-8,10-13,15H,14,16H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011631
PNG
(2-{3-[6-(2-Fluoro-phenyl)-1-trifluoromethyl-4H-2,3...)
Show SMILES Fc1ccccc1C1=NCc2nnc(n2-c2ccc(cc12)C#CCN1C(=O)c2ccccc2C1=O)C(F)(F)F |t:8|
Show InChI InChI=1S/C28H15F4N5O2/c29-21-10-4-3-9-19(21)24-20-14-16(6-5-13-36-25(38)17-7-1-2-8-18(17)26(36)39)11-12-22(20)37-23(15-33-24)34-35-27(37)28(30,31)32/h1-4,7-12,14H,13,15H2
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011632
PNG
(4-{3-[6-(2-Fluoro-phenyl)-1-methyl-4H-2,3,5,10b-te...)
Show SMILES Cc1nnc2CN=C(c3ccccc3F)c3cc(ccc3-n12)C#CCN1C(=O)COc2ccccc12 |t:6|
Show InChI InChI=1S/C28H20FN5O2/c1-18-31-32-26-16-30-28(20-8-2-3-9-22(20)29)21-15-19(12-13-23(21)34(18)26)7-6-14-33-24-10-4-5-11-25(24)36-17-27(33)35/h2-5,8-13,15H,14,16-17H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011624
PNG
(2-(3-Benzoimidazol-1-yl-prop-1-ynyl)-4-(2-chloro-p...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCn1cnc2ccccc12)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C25H17ClN6S/c1-16-29-30-23-14-27-24(18-8-2-3-9-20(18)26)19-13-17(33-25(19)32(16)23)7-6-12-31-15-28-21-10-4-5-11-22(21)31/h2-5,8-11,13,15H,12,14H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011660
PNG
(1-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCN1C(=O)NCc2ccccc12)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C26H19ClN6OS/c1-16-30-31-23-15-28-24(19-9-3-4-10-21(19)27)20-13-18(35-25(20)33(16)23)8-6-12-32-22-11-5-2-7-17(22)14-29-26(32)34/h2-5,7,9-11,13H,12,14-15H2,1H3,(H,29,34)
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011648
PNG
(1-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCn1c2ccccc2n(C=C=C)c1=O)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C28H19ClN6OS/c1-3-14-33-23-12-6-7-13-24(23)34(28(33)36)15-8-9-19-16-21-26(20-10-4-5-11-22(20)29)30-17-25-32-31-18(2)35(25)27(21)37-19/h4-7,10-14,16H,1,15,17H2,2H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011612
PNG
(1-{3-[6-(2-Fluoro-phenyl)-1,4-dimethyl-4H-2,3,5,10...)
Show SMILES C[C@@H]1N=C(c2ccccc2F)c2cc(ccc2-n2c(C)nnc12)C#CCN1C(=O)CCc2ccccc12 |t:2|
Show InChI InChI=1S/C30H24FN5O/c1-19-30-34-33-20(2)36(30)27-15-13-21(18-24(27)29(32-19)23-10-4-5-11-25(23)31)8-7-17-35-26-12-6-3-9-22(26)14-16-28(35)37/h3-6,9-13,15,18-19H,14,16-17H2,1-2H3/t19-/m0/s1
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011625
PNG
(5-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCn1c2ccccc2c(=O)c2ccccc2c1=O)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C32H20ClN5O2S/c1-19-35-36-28-18-34-29(23-12-4-6-14-26(23)33)25-17-20(41-32(25)38(19)28)9-8-16-37-27-15-7-5-13-24(27)30(39)21-10-2-3-11-22(21)31(37)40/h2-7,10-15,17H,16,18H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011607
PNG
(1-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCN1C(=O)C(=O)c2ccccc12)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C26H16ClN5O2S/c1-15-29-30-22-14-28-23(17-8-2-4-10-20(17)27)19-13-16(35-26(19)32(15)22)7-6-12-31-21-11-5-3-9-18(21)24(33)25(31)34/h2-5,8-11,13H,12,14H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011609
PNG
(7-Chloro-1-{3-[4-(2-chloro-phenyl)-9-methyl-6H-1-t...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCN1C(=O)CCc2ccc(Cl)cc12)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C27H19Cl2N5OS/c1-16-31-32-24-15-30-26(20-6-2-3-7-22(20)29)21-14-19(36-27(21)34(16)24)5-4-12-33-23-13-18(28)10-8-17(23)9-11-25(33)35/h2-3,6-8,10,13-14H,9,11-12,15H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011626
PNG
(4-{3-[6-(2-Fluoro-phenyl)-1-methyl-4H-2,3,5,10b-te...)
Show SMILES Cc1nnc2CN=C(c3ccccc3F)c3cc(ccc3-n12)C#CCN1C(=O)CSc2ccccc12 |t:6|
Show InChI InChI=1S/C28H20FN5OS/c1-18-31-32-26-16-30-28(20-8-2-3-9-22(20)29)21-15-19(12-13-23(21)34(18)26)7-6-14-33-24-10-4-5-11-25(24)36-17-27(33)35/h2-5,8-13,15H,14,16-17H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011605
PNG
(4-(2-Chloro-phenyl)-9-methyl-2-[3-(1,2,3,4-tetrahy...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCn1c2CCCCc2c2ccccc12)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C30H24ClN5S/c1-19-33-34-28-18-32-29(23-12-2-5-13-25(23)31)24-17-20(37-30(24)36(19)28)9-8-16-35-26-14-6-3-10-21(26)22-11-4-7-15-27(22)35/h2-3,5-6,10,12-14,17H,4,7,11,15-16,18H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011651
PNG
(6,8-Dichloro-1-{3-[4-(2-chloro-phenyl)-9-methyl-6H...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCN1C(=O)CCc2cc(Cl)cc(Cl)c12)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C27H18Cl3N5OS/c1-15-32-33-23-14-31-25(19-6-2-3-7-21(19)29)20-13-18(37-27(20)35(15)23)5-4-10-34-24(36)9-8-16-11-17(28)12-22(30)26(16)34/h2-3,6-7,11-13H,8-10,14H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011613
PNG
(1-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCn1c2ccccc2[nH]c1=O)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C25H17ClN6OS/c1-15-29-30-22-14-27-23(17-8-2-3-9-19(17)26)18-13-16(34-24(18)32(15)22)7-6-12-31-21-11-5-4-10-20(21)28-25(31)33/h2-5,8-11,13H,12,14H2,1H3,(H,28,33)
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011665
PNG
(2-{3-[6-(2-Fluoro-phenyl)-1-methyl-4H-2,3,5,10b-te...)
Show SMILES Cc1nnc2CN=C(c3ccccc3F)c3cc(ccc3-n12)C#CCN1C(=O)c2ccccc2C1=O |t:6|
Show InChI InChI=1S/C28H18FN5O2/c1-17-31-32-25-16-30-26(21-10-4-5-11-23(21)29)22-15-18(12-13-24(22)34(17)25)7-6-14-33-27(35)19-8-2-3-9-20(19)28(33)36/h2-5,8-13,15H,14,16H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011668
PNG
(1-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCN1C(=O)CC(C)(C)c2ccccc12)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C29H24ClN5OS/c1-18-32-33-25-17-31-27(20-10-4-6-12-23(20)30)21-15-19(37-28(21)35(18)25)9-8-14-34-24-13-7-5-11-22(24)29(2,3)16-26(34)36/h4-7,10-13,15H,14,16-17H2,1-3H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011642
PNG
(2-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCN1C(=O)c2cccc3cccc(C1=O)c23)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C30H18ClN5O2S/c1-17-33-34-25-16-32-27(20-10-2-3-13-24(20)31)23-15-19(39-30(23)36(17)25)9-6-14-35-28(37)21-11-4-7-18-8-5-12-22(26(18)21)29(35)38/h2-5,7-8,10-13,15H,14,16H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011676
PNG
(1-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCN1C(=O)C2(C)CCCc3cccc1c23)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C30H24ClN5OS/c1-18-33-34-25-17-32-27(21-11-3-4-12-23(21)31)22-16-20(38-28(22)36(18)25)10-7-15-35-24-13-5-8-19-9-6-14-30(2,26(19)24)29(35)37/h3-5,8,11-13,16H,6,9,14-15,17H2,1-2H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011638
PNG
(5-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCn1c2ccccc2c2ccccc2c1=O)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C31H20ClN5OS/c1-19-34-35-28-18-33-29(24-13-4-6-14-26(24)32)25-17-20(39-31(25)37(19)28)9-8-16-36-27-15-7-5-11-22(27)21-10-2-3-12-23(21)30(36)38/h2-7,10-15,17H,16,18H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011619
PNG
(2-{3-[6-(2-Chloro-phenyl)-1-methyl-4H-2,3,5,10b-te...)
Show SMILES Cc1nnc2CN=C(c3ccccc3Cl)c3cc(ccc3-n12)C#CCN1C(=O)c2cccc3cccc(C1=O)c23 |t:6|
Show InChI InChI=1S/C32H20ClN5O2/c1-19-35-36-28-18-34-30(22-10-2-3-13-26(22)33)25-17-20(14-15-27(25)38(19)28)7-6-16-37-31(39)23-11-4-8-21-9-5-12-24(29(21)23)32(37)40/h2-5,8-15,17H,16,18H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011604
PNG
(5-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCn1c2CCCCCc2c2ccccc12)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C31H26ClN5S/c1-20-34-35-29-19-33-30(24-13-5-7-14-26(24)32)25-18-21(38-31(25)37(20)29)10-9-17-36-27-15-4-2-3-11-22(27)23-12-6-8-16-28(23)36/h5-8,12-14,16,18H,2-4,11,15,17,19H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011675
PNG
(5-{3-[4-(6-Chloro-3-oxo-cyclohexa-1,5-dienyl)-9-me...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCn1c2ccccc2c2ccccc2c1=O)c1cc(O)ccc1Cl |c:6|
Show InChI InChI=1S/C31H20ClN5O2S/c1-18-34-35-28-17-33-29(24-15-19(38)12-13-26(24)32)25-16-20(40-31(25)37(18)28)7-6-14-36-27-11-5-4-9-22(27)21-8-2-3-10-23(21)30(36)39/h2-5,8-13,15-16,38H,14,17H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011629
PNG
(7-Chloro-1-{3-[4-(2-chloro-phenyl)-9-methyl-6H-1-t...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCN1C(=O)Cn2ccc3c(Cl)ccc1c23)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C28H18Cl2N6OS/c1-16-32-33-24-14-31-26(18-6-2-3-7-21(18)29)20-13-17(38-28(20)36(16)24)5-4-11-35-23-9-8-22(30)19-10-12-34(27(19)23)15-25(35)37/h2-3,6-10,12-13H,11,14-15H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011670
PNG
(1-{3-[6-(2-Fluoro-phenyl)-1-methyl-4H-2,3,5,10b-te...)
Show SMILES Cc1nnc2CN=C(c3ccccc3F)c3cc(ccc3-n12)C#CCN1C(=O)CCc2ccccc12 |t:6|
Show InChI InChI=1S/C29H22FN5O/c1-19-32-33-27-18-31-29(22-9-3-4-10-24(22)30)23-17-20(12-14-26(23)35(19)27)7-6-16-34-25-11-5-2-8-21(25)13-15-28(34)36/h2-5,8-12,14,17H,13,15-16,18H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011659
PNG
(2-{3-[6-(2-Chloro-phenyl)-1-methyl-4H-2,3,5,10b-te...)
Show SMILES Cc1nnc2CN=C(c3ccccc3Cl)c3cc(ccc3-n12)C#CCN1C(=O)c2ccccc2C1=O |t:6|
Show InChI InChI=1S/C28H18ClN5O2/c1-17-31-32-25-16-30-26(21-10-4-5-11-23(21)29)22-15-18(12-13-24(22)34(17)25)7-6-14-33-27(35)19-8-2-3-9-20(19)28(33)36/h2-5,8-13,15H,14,16H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011672
PNG
(2-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES COc1cc2CCN(CC#Cc3cc4c(s3)-n3c(C)nnc3CN=C4c3ccccc3Cl)C(=O)c2cc1OC |c:25|
Show InChI InChI=1S/C29H24ClN5O3S/c1-17-32-33-26-16-31-27(20-8-4-5-9-23(20)30)22-14-19(39-29(22)35(17)26)7-6-11-34-12-10-18-13-24(37-2)25(38-3)15-21(18)28(34)36/h4-5,8-9,13-15H,10-12,16H2,1-3H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011614
PNG
(5-{3-[4-(2-Chloro-phenyl)-6-hydroxy-9-methyl-6H-1-...)
Show SMILES Cc1nnc2C(O)N=C(c3cc(sc3-n12)C#CCn1c2ccccc2c2ccccc2c1=O)c1ccccc1Cl |c:7|
Show InChI InChI=1S/C31H20ClN5O2S/c1-18-34-35-28-29(38)33-27(23-13-4-6-14-25(23)32)24-17-19(40-31(24)37(18)28)9-8-16-36-26-15-7-5-11-21(26)20-10-2-3-12-22(20)30(36)39/h2-7,10-15,17,29,38H,16H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011641
PNG
(10-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCn1c2ccccc2c(=O)c2ccccc12)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C31H20ClN5OS/c1-19-34-35-28-18-33-29(21-10-2-5-13-25(21)32)24-17-20(39-31(24)37(19)28)9-8-16-36-26-14-6-3-11-22(26)30(38)23-12-4-7-15-27(23)36/h2-7,10-15,17H,16,18H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011667
PNG
(3,8-Dichloro-5-{3-[4-(2-chloro-phenyl)-9-methyl-6H...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCn1c2cc(Cl)ccc2c2ccc(Cl)cc2c1=O)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C31H18Cl3N5OS/c1-17-36-37-28-16-35-29(23-6-2-3-7-26(23)34)25-15-20(41-31(25)39(17)28)5-4-12-38-27-14-19(33)9-11-22(27)21-10-8-18(32)13-24(21)30(38)40/h2-3,6-11,13-15H,12,16H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011618
PNG
(1-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES CN(C)CCn1c2ccccc2n(CC#Cc2cc3c(s2)-n2c(C)nnc2CN=C3c2ccccc2Cl)c1=O |c:31|
Show InChI InChI=1S/C29H26ClN7OS/c1-19-32-33-26-18-31-27(21-10-4-5-11-23(21)30)22-17-20(39-28(22)37(19)26)9-8-14-35-24-12-6-7-13-25(24)36(29(35)38)16-15-34(2)3/h4-7,10-13,17H,14-16,18H2,1-3H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011671
PNG
((2E,4E)-5-(4-Methoxy-phenyl)-deca-2,4-dienoic acid...)
Show SMILES CCCCC\C(=C/C=C/C(=O)N[C@H](C)CCCc1cccnc1)c1ccc(OC)cc1
Show InChI InChI=1S/C27H36N2O2/c1-4-5-6-13-24(25-16-18-26(31-3)19-17-25)14-8-15-27(30)29-22(2)10-7-11-23-12-9-20-28-21-23/h8-9,12,14-22H,4-7,10-11,13H2,1-3H3,(H,29,30)/b15-8+,24-14+/t22-/m1/s1
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011645
PNG
(2-{4-[6-(2-Fluoro-phenyl)-1-methyl-4H-2,3,5,10b-te...)
Show SMILES Cc1nnc2CN=C(c3ccccc3F)c3cc(ccc3-n12)C#CCCN1C(=O)c2ccccc2C1=O |t:6|
Show InChI InChI=1S/C29H20FN5O2/c1-18-32-33-26-17-31-27(22-11-4-5-12-24(22)30)23-16-19(13-14-25(23)35(18)26)8-6-7-15-34-28(36)20-9-2-3-10-21(20)29(34)37/h2-5,9-14,16H,7,15,17H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011636
PNG
(1-{3-[6-(2-Fluoro-phenyl)-4-hydroxy-1-methyl-4H-2,...)
Show SMILES Cc1nnc2C(O)N=C(c3ccccc3F)c3cc(ccc3-n12)C#CCN1C(=O)CCc2ccccc12 |t:7|
Show InChI InChI=1S/C29H22FN5O2/c1-18-32-33-28-29(37)31-27(21-9-3-4-10-23(21)30)22-17-19(12-14-25(22)35(18)28)7-6-16-34-24-11-5-2-8-20(24)13-15-26(34)36/h2-5,8-12,14,17,29,37H,13,15-16H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011622
PNG
(6-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCn1c(=O)c2ccccc2c2ccccc2c1=O)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C32H20ClN5O2S/c1-19-35-36-28-18-34-29(25-14-6-7-15-27(25)33)26-17-20(41-32(26)38(19)28)9-8-16-37-30(39)23-12-4-2-10-21(23)22-11-3-5-13-24(22)31(37)40/h2-7,10-15,17H,16,18H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011633
PNG
(2-Chloro-5-{3-[4-(2-chloro-phenyl)-9-methyl-6H-1-t...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCn1c2CCCCCc2c2cc(Cl)ccc12)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C31H25Cl2N5S/c1-19-35-36-29-18-34-30(23-10-5-6-11-26(23)33)25-17-21(39-31(25)38(19)29)8-7-15-37-27-12-4-2-3-9-22(27)24-16-20(32)13-14-28(24)37/h5-6,10-11,13-14,16-17H,2-4,9,12,15,18H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011644
PNG
(1-{3-[4-(2-Chloro-5-nitro-phenyl)-9-methyl-6H-1-th...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCN1C(=O)CCc2ccccc12)c1cc(ccc1Cl)[N+]([O-])=O |c:6|
Show InChI InChI=1S/C27H19ClN6O3S/c1-16-30-31-24-15-29-26(20-13-18(34(36)37)9-10-22(20)28)21-14-19(38-27(21)33(16)24)6-4-12-32-23-7-3-2-5-17(23)8-11-25(32)35/h2-3,5,7,9-10,13-14H,8,11-12,15H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011616
PNG
(5-{3-[4-(2-Chloro-phenyl)-9-hydroxymethyl-6H-1-thi...)
Show SMILES OCc1nnc2CN=C(c3cc(sc3-n12)C#CCn1c2ccccc2c2ccccc2c1=O)c1ccccc1Cl |c:7|
Show InChI InChI=1S/C31H20ClN5O2S/c32-25-13-5-3-12-23(25)29-24-16-19(40-31(24)37-27(17-33-29)34-35-28(37)18-38)8-7-15-36-26-14-6-4-10-21(26)20-9-1-2-11-22(20)30(36)39/h1-6,9-14,16,38H,15,17-18H2
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011608
PNG
(1-{3-[4-(6-Chloro-3-oxo-cyclohexa-1,5-dienyl)-9-me...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCN1C(=O)CCc2ccccc12)c1cc(O)ccc1Cl |c:6|
Show InChI InChI=1S/C27H20ClN5O2S/c1-16-30-31-24-15-29-26(20-13-18(34)9-10-22(20)28)21-14-19(36-27(21)33(16)24)6-4-12-32-23-7-3-2-5-17(23)8-11-25(32)35/h2-3,5,7,9-10,13-14,34H,8,11-12,15H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011601
PNG
(4-(2-Chloro-phenyl)-2-[3-(6-chloro-1,2,3,4-tetrahy...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCn1c2CCCCc2c2cc(Cl)ccc12)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C30H23Cl2N5S/c1-18-34-35-28-17-33-29(22-9-2-4-10-25(22)32)24-16-20(38-30(24)37(18)28)7-6-14-36-26-11-5-3-8-21(26)23-15-19(31)12-13-27(23)36/h2,4,9-10,12-13,15-16H,3,5,8,11,14,17H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011606
PNG
(1-{3-[6-(4-Chloro-phenyl)-1-methyl-4H-2,3,5,10b-te...)
Show SMILES Cc1nnc2CN=C(c3ccc(Cl)cc3)c3cc(ccc3-n12)C#CCN1C(=O)CCc2ccccc12 |t:6|
Show InChI InChI=1S/C29H22ClN5O/c1-19-32-33-27-18-31-29(22-9-12-23(30)13-10-22)24-17-20(8-14-26(24)35(19)27)5-4-16-34-25-7-3-2-6-21(25)11-15-28(34)36/h2-3,6-10,12-14,17H,11,15-16,18H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011639
PNG
(1-{3-[6-(2-Fluoro-phenyl)-4-methoxy-1-methyl-4H-2,...)
Show SMILES COC1N=C(c2ccccc2F)c2cc(ccc2-n2c(C)nnc12)C#CCN1C(=O)CCc2ccccc12 |t:3|
Show InChI InChI=1S/C30H24FN5O2/c1-19-33-34-29-30(38-2)32-28(22-10-4-5-11-24(22)31)23-18-20(13-15-26(23)36(19)29)8-7-17-35-25-12-6-3-9-21(25)14-16-27(35)37/h3-6,9-13,15,18,30H,14,16-17H2,1-2H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011620
PNG
(2-{3-[1-Ethyl-6-(2-fluoro-phenyl)-4H-2,3,5,10b-tet...)
Show SMILES CCc1nnc2CN=C(c3ccccc3F)c3cc(ccc3-n12)C#CCN1C(=O)c2ccccc2C1=O |t:7|
Show InChI InChI=1S/C29H20FN5O2/c1-2-25-32-33-26-17-31-27(21-11-5-6-12-23(21)30)22-16-18(13-14-24(22)35(25)26)8-7-15-34-28(36)19-9-3-4-10-20(19)29(34)37/h3-6,9-14,16H,2,15,17H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011610
PNG
(2-{3-[6-(2-Fluoro-phenyl)-1-methyl-5,6-dihydro-4H-...)
Show SMILES Cc1nnc2CNC(c3ccccc3F)c3cc(ccc3-n12)C#CCN1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C28H20FN5O2/c1-17-31-32-25-16-30-26(21-10-4-5-11-23(21)29)22-15-18(12-13-24(22)34(17)25)7-6-14-33-27(35)19-8-2-3-9-20(19)28(33)36/h2-5,8-13,15,26,30H,14,16H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011662
PNG
(2-(3-Carbazol-9-yl-prop-1-ynyl)-4-(2-chloro-phenyl...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCn1c2ccccc2c2ccccc12)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C30H20ClN5S/c1-19-33-34-28-18-32-29(23-12-2-5-13-25(23)31)24-17-20(37-30(24)36(19)28)9-8-16-35-26-14-6-3-10-21(26)22-11-4-7-15-27(22)35/h2-7,10-15,17H,16,18H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011657
PNG
(4-(2-Chloro-phenyl)-2-iodo-6,9-dimethyl-6H-1-thia-...)
Show SMILES CC1N=C(c2cc(I)sc2-n2c(C)nnc12)c1ccccc1Cl |c:2|
Show InChI InChI=1S/C16H12ClIN4S/c1-8-15-21-20-9(2)22(15)16-11(7-13(18)23-16)14(19-8)10-5-3-4-6-12(10)17/h3-8H,1-2H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011643
PNG
(6-(2-Chloro-phenyl)-1-methyl-8-[3-(pyridin-3-yloxy...)
Show SMILES Cc1nnc2CN=C(c3ccccc3Cl)c3cc(ccc3-n12)C#CCOc1cccnc1 |t:6|
Show InChI InChI=1S/C25H18ClN5O/c1-17-29-30-24-16-28-25(20-8-2-3-9-22(20)26)21-14-18(10-11-23(21)31(17)24)6-5-13-32-19-7-4-12-27-15-19/h2-4,7-12,14-15H,13,16H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011652
PNG
(1-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES CN(C)CCn1c(=O)n(CC#Cc2cc3c(s2)-n2c(C)nnc2CN=C3c2ccccc2Cl)c2ccccc2c1=O |c:26|
Show InChI InChI=1S/C30H26ClN7O2S/c1-19-33-34-26-18-32-27(21-10-4-6-12-24(21)31)23-17-20(41-29(23)38(19)26)9-8-14-36-25-13-7-5-11-22(25)28(39)37(30(36)40)16-15-35(2)3/h4-7,10-13,17H,14-16,18H2,1-3H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011617
PNG
(1-{3-[6-(2-Fluoro-phenyl)-1-trifluoromethyl-4H-2,3...)
Show SMILES Fc1ccccc1C1=NCc2nnc(n2-c2ccc(cc12)C#CCN1C(=O)CCc2ccccc12)C(F)(F)F |t:8|
Show InChI InChI=1S/C29H19F4N5O/c30-22-9-3-2-8-20(22)27-21-16-18(6-5-15-37-23-10-4-1-7-19(23)12-14-26(37)39)11-13-24(21)38-25(17-34-27)35-36-28(38)29(31,32)33/h1-4,7-11,13,16H,12,14-15,17H2
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50000714
PNG
(3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a...)
Show SMILES Cc1nnc2CN=C(c3cc(CCC(=O)N4CCOCC4)sc3-n12)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C22H22ClN5O2S/c1-14-25-26-19-13-24-21(16-4-2-3-5-18(16)23)17-12-15(31-22(17)28(14)19)6-7-20(29)27-8-10-30-11-9-27/h2-5,12H,6-11,13H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011677
PNG
(5-{3-[4-(2-Chloro-phenyl)-6,9-dimethyl-6H-1-thia-5...)
Show SMILES CC1N=C(c2cc(sc2-n2c(C)nnc12)C#CCn1c2ccccc2c2ccccc2c1=O)c1ccccc1Cl |c:2|
Show InChI InChI=1S/C32H22ClN5OS/c1-19-30-36-35-20(2)38(30)32-26(29(34-19)25-14-5-7-15-27(25)33)18-21(40-32)10-9-17-37-28-16-8-6-12-23(28)22-11-3-4-13-24(22)31(37)39/h3-8,11-16,18-19H,17H2,1-2H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011654
PNG
(2-{3-[5-(2-Fluoro-phenyl)-1-methyl-5a,9a-dihydro-[...)
Show SMILES Cc1nnc2nc(-c3ccccc3F)c3cc(ccc3n12)C#CCN1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C27H16FN5O2/c1-16-30-31-27-29-24(20-10-4-5-11-22(20)28)21-15-17(12-13-23(21)33(16)27)7-6-14-32-25(34)18-8-2-3-9-19(18)26(32)35/h2-5,8-13,15H,14H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011630
PNG
(4-(2-Chloro-5-nitro-phenyl)-2-iodo-9-methyl-6H-1-t...)
Show SMILES Cc1nnc2CN=C(c3cc(I)sc3-n12)c1cc(ccc1Cl)[N+]([O-])=O |c:6|
Show InChI InChI=1S/C15H9ClIN5O2S/c1-7-19-20-13-6-18-14(10-5-12(17)25-15(10)21(7)13)9-4-8(22(23)24)2-3-11(9)16/h2-5H,6H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011628
PNG
(4-(2-Chloro-phenyl)-2-iodo-9-methyl-6H-1-thia-5,7,...)
Show SMILES Cc1nnc2CN=C(c3cc(I)sc3-n12)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C15H10ClIN4S/c1-8-19-20-13-7-18-14(9-4-2-3-5-11(9)16)10-6-12(17)22-15(10)21(8)13/h2-6H,7H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011647
PNG
(2-{3-[6-(2-Fluoro-phenyl)-1-methyl-4H,6H-5-oxa-2,3...)
Show SMILES Cc1nnc2COC(c3ccccc3F)c3cc(ccc3-n12)C#CCN1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C28H19FN4O3/c1-17-30-31-25-16-36-26(21-10-4-5-11-23(21)29)22-15-18(12-13-24(22)33(17)25)7-6-14-32-27(34)19-8-2-3-9-20(19)28(32)35/h2-5,8-13,15,26H,14,16H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011637
PNG
(4-(2-Chloro-phenyl)-9-methyl-2-[3-(6-oxo-6H-phenan...)
Show SMILES Cc1nnc2C(=O)NC(c3cc(sc3-n12)C#CCn1c2ccccc2c2ccccc2c1=O)c1ccccc1Cl
Show InChI InChI=1S/C31H20ClN5O2S/c1-18-34-35-28-29(38)33-27(23-13-4-6-14-25(23)32)24-17-19(40-31(24)37(18)28)9-8-16-36-26-15-7-5-11-21(26)20-10-2-3-12-22(20)30(36)39/h2-7,10-15,17,27H,16H2,1H3,(H,33,38)
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011615
PNG
(2-{3-[6-(2-Fluoro-phenyl)-4H-2,3,5,10b-tetraaza-be...)
Show SMILES Fc1ccccc1C1=NCc2nncn2-c2ccc(cc12)C#CCN1C(=O)c2ccccc2C1=O |t:8|
Show InChI InChI=1S/C27H16FN5O2/c28-22-10-4-3-9-20(22)25-21-14-17(11-12-23(21)33-16-30-31-24(33)15-29-25)6-5-13-32-26(34)18-7-1-2-8-19(18)27(32)35/h1-4,7-12,14,16H,13,15H2
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011674
PNG
(1-{3-[6-(4-Chloro-phenyl)-1-trifluoromethyl-4H-2,3...)
Show SMILES FC(F)(F)c1nnc2CN=C(c3ccc(Cl)cc3)c3cc(ccc3-n12)C#CCN1C(=O)CCc2ccccc12 |t:9|
Show InChI InChI=1S/C29H19ClF3N5O/c30-21-11-8-20(9-12-21)27-22-16-18(4-3-15-37-23-6-2-1-5-19(23)10-14-26(37)39)7-13-24(22)38-25(17-34-27)35-36-28(38)29(31,32)33/h1-2,5-9,11-13,16H,10,14-15,17H2
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011656
PNG
(6-(2-Fluoro-phenyl)-8-iodo-1-methyl-5,6-dihydro-4H...)
Show SMILES Cc1nnc2CNC(c3ccccc3F)c3cc(I)ccc3-n12
Show InChI InChI=1S/C17H14FIN4/c1-10-21-22-16-9-20-17(12-4-2-3-5-14(12)18)13-8-11(19)6-7-15(13)23(10)16/h2-8,17,20H,9H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011658
PNG
(1-{3-[6-(2-Fluoro-phenyl)-1,4-dimethyl-4H-2,3,5,10...)
Show SMILES C[C@H]1N=C(c2ccccc2F)c2cc(ccc2-n2c(C)nnc12)C#CCN1C(=O)CCc2ccccc12 |t:2|
Show InChI InChI=1S/C30H24FN5O/c1-19-30-34-33-20(2)36(30)27-15-13-21(18-24(27)29(32-19)23-10-4-5-11-25(23)31)8-7-17-35-26-12-6-3-9-22(26)14-16-28(35)37/h3-6,9-13,15,18-19H,14,16-17H2,1-2H3/t19-/m1/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011664
PNG
(6-(2-Chloro-phenyl)-8-iodo-1-methyl-4H-2,3,5,10b-t...)
Show SMILES Cc1nnc2CN=C(c3ccccc3Cl)c3cc(I)ccc3-n12 |t:6|
Show InChI InChI=1S/C17H12ClIN4/c1-10-21-22-16-9-20-17(12-4-2-3-5-14(12)18)13-8-11(19)6-7-15(13)23(10)16/h2-8H,9H2,1H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011621
PNG
(6-(2-Fluoro-phenyl)-8-iodo-1-methyl-4H-2,3,5,10b-t...)
Show SMILES Cc1nnc2CN=C(c3ccccc3F)c3cc(I)ccc3-n12 |t:6|
Show InChI InChI=1S/C17H12FIN4/c1-10-21-22-16-9-20-17(12-4-2-3-5-14(12)18)13-8-11(19)6-7-15(13)23(10)16/h2-8H,9H2,1H3
PDB

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n/an/a 1.00E+3n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%