Found 98 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50293594
(5-(2-amino-5-isobutylthiazol-4-yl)furan-2-ylphosph...)Show InChI InChI=1S/C11H15N2O4PS/c1-6(2)5-8-10(13-11(12)19-8)7-3-4-9(17-7)18(14,15)16/h3-4,6H,5H2,1-2H3,(H2,12,13)(H2,14,15,16) | PDB
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CHEMBL
MCE
PC cid
PC sid
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| PDB
Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303863
(4-Amino-5-fluoro-1-cyclopropylmethyl-2-[5-(2-phosp...)Show SMILES Nc1c(F)ccc2n(CC3CC3)c(nc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C15H15FN3O4P/c16-9-3-4-10-14(13(9)17)18-15(19(10)7-8-1-2-8)11-5-6-12(23-11)24(20,21)22/h3-6,8H,1-2,7,17H2,(H2,20,21,22) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303854
(5-(4-amino-7-ethyl-5-fluoro-1-isobutyl-1H-benzo[d]...)Show SMILES CCc1cc(F)c(N)c2nc(-c3ccc(o3)P(O)(O)=O)n(CC(C)C)c12 Show InChI InChI=1S/C17H21FN3O4P/c1-4-10-7-11(18)14(19)15-16(10)21(8-9(2)3)17(20-15)12-5-6-13(25-12)26(22,23)24/h5-7,9H,4,8,19H2,1-3H3,(H2,22,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303879
(4-Amino-5-fluoro-7-[3-(N,N-dimethylamino)propyl]-1...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)cc(CCCN(C)C)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C20H28FN4O4P/c1-12(2)11-25-19-13(6-5-9-24(3)4)10-14(21)17(22)18(19)23-20(25)15-7-8-16(29-15)30(26,27)28/h7-8,10,12H,5-6,9,11,22H2,1-4H3,(H2,26,27,28) | PDB
UniProtKB/SwissProt
antibodypedia
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PC sid
UniChem
Similars
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PubMed
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303871
(4-Amino-7-cyclopropyl-5-fluoro-1-isobutyl-2-[5-(2-...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)cc(C3CC3)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C18H21FN3O4P/c1-9(2)8-22-17-11(10-3-4-10)7-12(19)15(20)16(17)21-18(22)13-5-6-14(26-13)27(23,24)25/h5-7,9-10H,3-4,8,20H2,1-2H3,(H2,23,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303880
(4-Amino-5-fluoro-7-(4-chlorobutyl)-1-isobutyl-2-[5...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)cc(CCCCCl)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C19H24ClFN3O4P/c1-11(2)10-24-18-12(5-3-4-8-20)9-13(21)16(22)17(18)23-19(24)14-6-7-15(28-14)29(25,26)27/h6-7,9,11H,3-5,8,10,22H2,1-2H3,(H2,25,26,27) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303878
(4-Amino-7-(3-hydroxypropyl)-5-fluoro-1-isobutyl-2-...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)cc(CCCO)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C18H23FN3O5P/c1-10(2)9-22-17-11(4-3-7-23)8-12(19)15(20)16(17)21-18(22)13-5-6-14(27-13)28(24,25)26/h5-6,8,10,23H,3-4,7,9,20H2,1-2H3,(H2,24,25,26) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303874
(4-Amino-7-(p-chlorophenyl)-5-fluoro-1-isobutyl-2-[...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)cc(-c3ccc(Cl)cc3)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C21H20ClFN3O4P/c1-11(2)10-26-20-14(12-3-5-13(22)6-4-12)9-15(23)18(24)19(20)25-21(26)16-7-8-17(30-16)31(27,28)29/h3-9,11H,10,24H2,1-2H3,(H2,27,28,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303872
(4-Amino-7-phenyl-5-fluoro-1-isobutyl-2-[5-(2-phosp...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)cc(-c3ccccc3)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C21H21FN3O4P/c1-12(2)11-25-20-14(13-6-4-3-5-7-13)10-15(22)18(23)19(20)24-21(25)16-8-9-17(29-16)30(26,27)28/h3-10,12H,11,23H2,1-2H3,(H2,26,27,28) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303860
(4-Amino-5-fluoro-1-isobutyl-2-[5-(2-phosphono)fura...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)ccc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C15H17FN3O4P/c1-8(2)7-19-10-4-3-9(16)13(17)14(10)18-15(19)11-5-6-12(23-11)24(20,21)22/h3-6,8H,7,17H2,1-2H3,(H2,20,21,22) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303866
(4-Amino-5-fluoro-7-chloro-1-isobutyl-2-[5-(2-phosp...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)cc(Cl)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C15H16ClFN3O4P/c1-7(2)6-20-14-8(16)5-9(17)12(18)13(14)19-15(20)10-3-4-11(24-10)25(21,22)23/h3-5,7H,6,18H2,1-2H3,(H2,21,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303877
(4-Amino-7-(4-methylpentyl)-5-fluoro-1-isobutyl-2-[...)Show SMILES CC(C)CCCc1cc(F)c(N)c2nc(-c3ccc(o3)P(O)(O)=O)n(CC(C)C)c12 Show InChI InChI=1S/C21H29FN3O4P/c1-12(2)6-5-7-14-10-15(22)18(23)19-20(14)25(11-13(3)4)21(24-19)16-8-9-17(29-16)30(26,27)28/h8-10,12-13H,5-7,11,23H2,1-4H3,(H2,26,27,28) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303875
(4-Amino-5-fluoro-7-(n-propyl)-1-isobutyl-2-[5-(2-p...)Show SMILES CCCc1cc(F)c(N)c2nc(-c3ccc(o3)P(O)(O)=O)n(CC(C)C)c12 Show InChI InChI=1S/C18H23FN3O4P/c1-4-5-11-8-12(19)15(20)16-17(11)22(9-10(2)3)18(21-16)13-6-7-14(26-13)27(23,24)25/h6-8,10H,4-5,9,20H2,1-3H3,(H2,23,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303867
(4-Amino-5-fluoro-7-bromo-1-isobutyl-2-[5-(2-phosph...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)cc(Br)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C15H16BrFN3O4P/c1-7(2)6-20-14-8(16)5-9(17)12(18)13(14)19-15(20)10-3-4-11(24-10)25(21,22)23/h3-5,7H,6,18H2,1-2H3,(H2,21,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303861
(4-Amino-5-fluoro-1-(2-ethylbutyl)-2-[5-(2-phosphon...)Show SMILES CCC(CC)Cn1c(nc2c(N)c(F)ccc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C17H21FN3O4P/c1-3-10(4-2)9-21-12-6-5-11(18)15(19)16(12)20-17(21)13-7-8-14(25-13)26(22,23)24/h5-8,10H,3-4,9,19H2,1-2H3,(H2,22,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303873
(4-Amino-7-(p-fluorophenyl)-5-fluoro-1-isobutyl-2-[...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)cc(-c3ccc(F)cc3)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C21H20F2N3O4P/c1-11(2)10-26-20-14(12-3-5-13(22)6-4-12)9-15(23)18(24)19(20)25-21(26)16-7-8-17(30-16)31(27,28)29/h3-9,11H,10,24H2,1-2H3,(H2,27,28,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303856
(4-Amino-5-chloro-1-isobutyl-2-[2-(5-phosphono)fura...)Show SMILES CC(C)Cn1c(nc2c(N)c(Cl)ccc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C15H17ClN3O4P/c1-8(2)7-19-10-4-3-9(16)13(17)14(10)18-15(19)11-5-6-12(23-11)24(20,21)22/h3-6,8H,7,17H2,1-2H3,(H2,20,21,22) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303876
(4-Amino-7-(3,3-dimethyl-n-butyl)-5-fluoro-1-isobut...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)cc(CCC(C)(C)C)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C21H29FN3O4P/c1-12(2)11-25-19-13(8-9-21(3,4)5)10-14(22)17(23)18(19)24-20(25)15-6-7-16(29-15)30(26,27)28/h6-7,10,12H,8-9,11,23H2,1-5H3,(H2,26,27,28) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303868
(4-Amino-5-fluoro-6-chloro-1-isobutyl-2-[5-(2-phosp...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)c(Cl)cc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C15H16ClFN3O4P/c1-7(2)6-20-9-5-8(16)12(17)13(18)14(9)19-15(20)10-3-4-11(24-10)25(21,22)23/h3-5,7H,6,18H2,1-2H3,(H2,21,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 225 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303870
(4-Amino-7-vinyl-5-fluoro-1-isobutyl-2-[5-(2-phosph...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)cc(C=C)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C17H19FN3O4P/c1-4-10-7-11(18)14(19)15-16(10)21(8-9(2)3)17(20-15)12-5-6-13(25-12)26(22,23)24/h4-7,9H,1,8,19H2,2-3H3,(H2,22,23,24) | PDB
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| n/a | n/a | 280 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303871
(4-Amino-7-cyclopropyl-5-fluoro-1-isobutyl-2-[5-(2-...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)cc(C3CC3)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C18H21FN3O4P/c1-9(2)8-22-17-11(10-3-4-10)7-12(19)15(20)16(17)21-18(22)13-5-6-14(26-13)27(23,24)25/h5-7,9-10H,3-4,8,20H2,1-2H3,(H2,23,24,25) | PDB
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| n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303879
(4-Amino-5-fluoro-7-[3-(N,N-dimethylamino)propyl]-1...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)cc(CCCN(C)C)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C20H28FN4O4P/c1-12(2)11-25-19-13(6-5-9-24(3)4)10-14(21)17(22)18(19)23-20(25)15-7-8-16(29-15)30(26,27)28/h7-8,10,12H,5-6,9,11,22H2,1-4H3,(H2,26,27,28) | PDB
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| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303859
(4-Amino-7-bromo-1-isobutyl-2-[2-(5-phosphono)furan...)Show SMILES CC(C)Cn1c(nc2c(N)ccc(Br)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C15H17BrN3O4P/c1-8(2)7-19-14-9(16)3-4-10(17)13(14)18-15(19)11-5-6-12(23-11)24(20,21)22/h3-6,8H,7,17H2,1-2H3,(H2,20,21,22) | PDB
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| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303858
(4-Amino-5-bromo-1-isobutyl-2-[2-(5-phosphono)furan...)Show SMILES CC(C)Cn1c(nc2c(N)c(Br)ccc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C15H17BrN3O4P/c1-8(2)7-19-10-4-3-9(16)13(17)14(10)18-15(19)11-5-6-12(23-11)24(20,21)22/h3-6,8H,7,17H2,1-2H3,(H2,20,21,22) | PDB
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| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303865
(4-Amino-5,7-dichloro-1-isobutyl-2-[5-(2-phosphono)...)Show SMILES CC(C)Cn1c(nc2c(N)c(Cl)cc(Cl)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C15H16Cl2N3O4P/c1-7(2)6-20-14-9(17)5-8(16)12(18)13(14)19-15(20)10-3-4-11(24-10)25(21,22)23/h3-5,7H,6,18H2,1-2H3,(H2,21,22,23) | PDB
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| n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303878
(4-Amino-7-(3-hydroxypropyl)-5-fluoro-1-isobutyl-2-...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)cc(CCCO)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C18H23FN3O5P/c1-10(2)9-22-17-11(4-3-7-23)8-12(19)15(20)16(17)21-18(22)13-5-6-14(27-13)28(24,25)26/h5-6,8,10,23H,3-4,7,9,20H2,1-2H3,(H2,24,25,26) | PDB
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| n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303855
(5-(4-amino-5-hydroxy-1-isobutyl-1H-benzo[d]imidazo...)Show SMILES CC(C)Cn1c(nc2c(N)c(O)ccc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C15H18N3O5P/c1-8(2)7-18-9-3-4-10(19)13(16)14(9)17-15(18)11-5-6-12(23-11)24(20,21)22/h3-6,8,19H,7,16H2,1-2H3,(H2,20,21,22) | PDB
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| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303880
(4-Amino-5-fluoro-7-(4-chlorobutyl)-1-isobutyl-2-[5...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)cc(CCCCCl)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C19H24ClFN3O4P/c1-11(2)10-24-18-12(5-3-4-8-20)9-13(21)16(22)17(18)23-19(24)14-6-7-15(28-14)29(25,26)27/h6-7,9,11H,3-5,8,10,22H2,1-2H3,(H2,25,26,27) | PDB
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| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303854
(5-(4-amino-7-ethyl-5-fluoro-1-isobutyl-1H-benzo[d]...)Show SMILES CCc1cc(F)c(N)c2nc(-c3ccc(o3)P(O)(O)=O)n(CC(C)C)c12 Show InChI InChI=1S/C17H21FN3O4P/c1-4-10-7-11(18)14(19)15-16(10)21(8-9(2)3)17(20-15)12-5-6-13(25-12)26(22,23)24/h5-7,9H,4,8,19H2,1-3H3,(H2,22,23,24) | PDB
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| n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303875
(4-Amino-5-fluoro-7-(n-propyl)-1-isobutyl-2-[5-(2-p...)Show SMILES CCCc1cc(F)c(N)c2nc(-c3ccc(o3)P(O)(O)=O)n(CC(C)C)c12 Show InChI InChI=1S/C18H23FN3O4P/c1-4-5-11-8-12(19)15(20)16-17(11)22(9-10(2)3)18(21-16)13-6-7-14(26-13)27(23,24)25/h6-8,10H,4-5,9,20H2,1-3H3,(H2,23,24,25) | PDB
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| n/a | n/a | 650 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303892
(4-Amino-5-methoxy-1-isobutyl-2-[5-(2-phosphono)fur...)Show SMILES COc1ccc2n(CC(C)C)c(nc2c1N)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C16H20N3O5P/c1-9(2)8-19-10-4-5-11(23-3)14(17)15(10)18-16(19)12-6-7-13(24-12)25(20,21)22/h4-7,9H,8,17H2,1-3H3,(H2,20,21,22) | PDB
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| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303886
(4-Amino-1-cyclobutylmethyl-2-[2-(5-phosphono)furan...)Show SMILES Nc1cccc2n(CC3CCC3)c(nc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C16H18N3O4P/c17-11-5-2-6-12-15(11)18-16(19(12)9-10-3-1-4-10)13-7-8-14(23-13)24(20,21)22/h2,5-8,10H,1,3-4,9,17H2,(H2,20,21,22) | PDB
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| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50277565
(5-(6-amino-9-neopentyl-9H-purin-8-yl)furan-2-ylpho...)Show SMILES CC(C)(C)Cn1c(nc2c(N)ncnc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C14H18N5O4P/c1-14(2,3)6-19-12(8-4-5-9(23-8)24(20,21)22)18-10-11(15)16-7-17-13(10)19/h4-5,7H,6H2,1-3H3,(H2,15,16,17)(H2,20,21,22) | PDB
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| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303885
(4-Amino-1-cyclopropylmethyl-2-[2-(5-phosphono)fura...)Show SMILES Nc1cccc2n(CC3CC3)c(nc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C15H16N3O4P/c16-10-2-1-3-11-14(10)17-15(18(11)8-9-4-5-9)12-6-7-13(22-12)23(19,20)21/h1-3,6-7,9H,4-5,8,16H2,(H2,19,20,21) | PDB
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| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303862
(4-Amino-5-fluoro-1-(3-pentyl)-2-[5-(2-phosphono)fu...)Show SMILES CCC(CC)n1c(nc2c(N)c(F)ccc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C16H19FN3O4P/c1-3-9(4-2)20-11-6-5-10(17)14(18)15(11)19-16(20)12-7-8-13(24-12)25(21,22)23/h5-9H,3-4,18H2,1-2H3,(H2,21,22,23) | PDB
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| n/a | n/a | 850 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303861
(4-Amino-5-fluoro-1-(2-ethylbutyl)-2-[5-(2-phosphon...)Show SMILES CCC(CC)Cn1c(nc2c(N)c(F)ccc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C17H21FN3O4P/c1-3-10(4-2)9-21-12-6-5-11(18)15(19)16(12)20-17(21)13-7-8-14(25-13)26(22,23)24/h5-8,10H,3-4,9,19H2,1-2H3,(H2,22,23,24) | PDB
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| n/a | n/a | 850 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303857
(4-Amino-7-chloro-1-isobutyl-2-[2-(5-phosphono)fura...)Show SMILES CC(C)Cn1c(nc2c(N)ccc(Cl)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C15H17ClN3O4P/c1-8(2)7-19-14-9(16)3-4-10(17)13(14)18-15(19)11-5-6-12(23-11)24(20,21)22/h3-6,8H,7,17H2,1-2H3,(H2,20,21,22) | PDB
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| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303870
(4-Amino-7-vinyl-5-fluoro-1-isobutyl-2-[5-(2-phosph...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)cc(C=C)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C17H19FN3O4P/c1-4-10-7-11(18)14(19)15-16(10)21(8-9(2)3)17(20-15)12-5-6-13(25-12)26(22,23)24/h4-7,9H,1,8,19H2,2-3H3,(H2,22,23,24) | PDB
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| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303872
(4-Amino-7-phenyl-5-fluoro-1-isobutyl-2-[5-(2-phosp...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)cc(-c3ccccc3)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C21H21FN3O4P/c1-12(2)11-25-20-14(13-6-4-3-5-7-13)10-15(22)18(23)19(20)24-21(25)16-8-9-17(29-16)30(26,27)28/h3-10,12H,11,23H2,1-2H3,(H2,26,27,28) | PDB
MMDB
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UniProtKB/SwissProt
B.MOAD
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UniChem
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| Article
PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303864
(4-Amino-5,7-dibromo-1-isobutyl-2-[2-(5-phosphono)f...)Show SMILES CC(C)Cn1c(nc2c(N)c(Br)cc(Br)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C15H16Br2N3O4P/c1-7(2)6-20-14-9(17)5-8(16)12(18)13(14)19-15(20)10-3-4-11(24-10)25(21,22)23/h3-5,7H,6,18H2,1-2H3,(H2,21,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303893
(4-Amino-1-norbornylmethyl-2-[2-(5-phosphono)furany...)Show SMILES Nc1cccc2n(CC34CCC(CC3)C4)c(nc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C19H22N3O4P/c20-13-2-1-3-14-17(13)21-18(15-4-5-16(26-15)27(23,24)25)22(14)11-19-8-6-12(10-19)7-9-19/h1-5,12H,6-11,20H2,(H2,23,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303883
(4-Amino-L-propyl-2-[2-(5-phosphono)furanyl]benzimi...)Show InChI InChI=1S/C14H16N3O4P/c1-2-8-17-10-5-3-4-9(15)13(10)16-14(17)11-6-7-12(21-11)22(18,19)20/h3-7H,2,8,15H2,1H3,(H2,18,19,20) | PDB
UniProtKB/SwissProt
antibodypedia
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UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303873
(4-Amino-7-(p-fluorophenyl)-5-fluoro-1-isobutyl-2-[...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)cc(-c3ccc(F)cc3)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C21H20F2N3O4P/c1-11(2)10-26-20-14(12-3-5-13(22)6-4-12)9-15(23)18(24)19(20)25-21(26)16-7-8-17(30-16)31(27,28)29/h3-9,11H,10,24H2,1-2H3,(H2,27,28,29) | PDB
MMDB
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UniProtKB/SwissProt
B.MOAD
GoogleScholar
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| CHEMBL
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PC sid
UniChem
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Similars
| Article
PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303887
(4-Amino-1-cyclopentylmethyl-2-[2-(5-phosphono)fura...)Show SMILES Nc1cccc2n(CC3CCCC3)c(nc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C17H20N3O4P/c18-12-6-3-7-13-16(12)19-17(20(13)10-11-4-1-2-5-11)14-8-9-15(24-14)25(21,22)23/h3,6-9,11H,1-2,4-5,10,18H2,(H2,21,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
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UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303884
(4-Amino-l-isobutyl-2-[2-(5-phosphono)furanyl]benzi...)Show SMILES CC(C)Cn1c(nc2c(N)cccc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C15H18N3O4P/c1-9(2)8-18-11-5-3-4-10(16)14(11)17-15(18)12-6-7-13(22-12)23(19,20)21/h3-7,9H,8,16H2,1-2H3,(H2,19,20,21) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
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PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50277564
(5-(6-amino-9-isobutyl-9H-purin-8-yl)furan-2-ylphos...)Show SMILES CC(C)Cn1c(nc2c(N)ncnc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C13H16N5O4P/c1-7(2)5-18-12(8-3-4-9(22-8)23(19,20)21)17-10-11(14)15-6-16-13(10)18/h3-4,6-7H,5H2,1-2H3,(H2,14,15,16)(H2,19,20,21) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
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Similars
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PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303876
(4-Amino-7-(3,3-dimethyl-n-butyl)-5-fluoro-1-isobut...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)cc(CCC(C)(C)C)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C21H29FN3O4P/c1-12(2)11-25-19-13(8-9-21(3,4)5)10-14(22)17(23)18(19)24-20(25)15-6-7-16(29-15)30(26,27)28/h6-7,10,12H,8-9,11,23H2,1-5H3,(H2,26,27,28) | PDB
MMDB
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UniProtKB/SwissProt
B.MOAD
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PC sid
UniChem
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Similars
| Article
PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303899
(4-Amino-1-(3-hydroxybenzyl)-2-[2-(5-phosphono)fura...)Show SMILES Nc1cccc2n(Cc3cccc(O)c3)c(nc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C18H16N3O5P/c19-13-5-2-6-14-17(13)20-18(15-7-8-16(26-15)27(23,24)25)21(14)10-11-3-1-4-12(22)9-11/h1-9,22H,10,19H2,(H2,23,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
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Similars
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PubMed
| n/a | n/a | 1.85E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303856
(4-Amino-5-chloro-1-isobutyl-2-[2-(5-phosphono)fura...)Show SMILES CC(C)Cn1c(nc2c(N)c(Cl)ccc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C15H17ClN3O4P/c1-8(2)7-19-10-4-3-9(16)13(17)14(10)18-15(19)11-5-6-12(23-11)24(20,21)22/h3-6,8H,7,17H2,1-2H3,(H2,20,21,22) | PDB
MMDB
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| Article
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303892
(4-Amino-5-methoxy-1-isobutyl-2-[5-(2-phosphono)fur...)Show SMILES COc1ccc2n(CC(C)C)c(nc2c1N)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C16H20N3O5P/c1-9(2)8-19-10-4-5-11(23-3)14(17)15(10)18-16(19)12-6-7-13(24-12)25(20,21)22/h4-7,9H,8,17H2,1-3H3,(H2,20,21,22) | PDB
MMDB
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| Article
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303887
(4-Amino-1-cyclopentylmethyl-2-[2-(5-phosphono)fura...)Show SMILES Nc1cccc2n(CC3CCCC3)c(nc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C17H20N3O4P/c18-12-6-3-7-13-16(12)19-17(20(13)10-11-4-1-2-5-11)14-8-9-15(24-14)25(21,22)23/h3,6-9,11H,1-2,4-5,10,18H2,(H2,21,22,23) | PDB
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Similars
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PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303864
(4-Amino-5,7-dibromo-1-isobutyl-2-[2-(5-phosphono)f...)Show SMILES CC(C)Cn1c(nc2c(N)c(Br)cc(Br)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C15H16Br2N3O4P/c1-7(2)6-20-14-9(17)5-8(16)12(18)13(14)19-15(20)10-3-4-11(24-10)25(21,22)23/h3-5,7H,6,18H2,1-2H3,(H2,21,22,23) | PDB
MMDB
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Similars
| Article
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303859
(4-Amino-7-bromo-1-isobutyl-2-[2-(5-phosphono)furan...)Show SMILES CC(C)Cn1c(nc2c(N)ccc(Br)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C15H17BrN3O4P/c1-8(2)7-19-14-9(16)3-4-10(17)13(14)18-15(19)11-5-6-12(23-11)24(20,21)22/h3-6,8H,7,17H2,1-2H3,(H2,20,21,22) | PDB
MMDB
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Similars
| Article
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303893
(4-Amino-1-norbornylmethyl-2-[2-(5-phosphono)furany...)Show SMILES Nc1cccc2n(CC34CCC(CC3)C4)c(nc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C19H22N3O4P/c20-13-2-1-3-14-17(13)21-18(15-4-5-16(26-15)27(23,24)25)22(14)11-19-8-6-12(10-19)7-9-19/h1-5,12H,6-11,20H2,(H2,23,24,25) | PDB
MMDB
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Similars
| Article
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303886
(4-Amino-1-cyclobutylmethyl-2-[2-(5-phosphono)furan...)Show SMILES Nc1cccc2n(CC3CCC3)c(nc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C16H18N3O4P/c17-11-5-2-6-12-15(11)18-16(19(12)9-10-3-1-4-10)13-7-8-14(23-13)24(20,21)22/h2,5-8,10H,1,3-4,9,17H2,(H2,20,21,22) | PDB
MMDB
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Similars
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PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303865
(4-Amino-5,7-dichloro-1-isobutyl-2-[5-(2-phosphono)...)Show SMILES CC(C)Cn1c(nc2c(N)c(Cl)cc(Cl)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C15H16Cl2N3O4P/c1-7(2)6-20-14-9(17)5-8(16)12(18)13(14)19-15(20)10-3-4-11(24-10)25(21,22)23/h3-5,7H,6,18H2,1-2H3,(H2,21,22,23) | PDB
MMDB
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PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303883
(4-Amino-L-propyl-2-[2-(5-phosphono)furanyl]benzimi...)Show InChI InChI=1S/C14H16N3O4P/c1-2-8-17-10-5-3-4-9(15)13(10)16-14(17)11-6-7-12(21-11)22(18,19)20/h3-7H,2,8,15H2,1H3,(H2,18,19,20) | PDB
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| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303874
(4-Amino-7-(p-chlorophenyl)-5-fluoro-1-isobutyl-2-[...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)cc(-c3ccc(Cl)cc3)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C21H20ClFN3O4P/c1-11(2)10-26-20-14(12-3-5-13(22)6-4-12)9-15(23)18(24)19(20)25-21(26)16-7-8-17(30-16)31(27,28)29/h3-9,11H,10,24H2,1-2H3,(H2,27,28,29) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303868
(4-Amino-5-fluoro-6-chloro-1-isobutyl-2-[5-(2-phosp...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)c(Cl)cc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C15H16ClFN3O4P/c1-7(2)6-20-9-5-8(16)12(17)13(18)14(9)19-15(20)10-3-4-11(24-10)25(21,22)23/h3-5,7H,6,18H2,1-2H3,(H2,21,22,23) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
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UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303866
(4-Amino-5-fluoro-7-chloro-1-isobutyl-2-[5-(2-phosp...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)cc(Cl)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C15H16ClFN3O4P/c1-7(2)6-20-14-8(16)5-9(17)12(18)13(14)19-15(20)10-3-4-11(24-10)25(21,22)23/h3-5,7H,6,18H2,1-2H3,(H2,21,22,23) | PDB
MMDB
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UniProtKB/SwissProt
B.MOAD
GoogleScholar
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| CHEMBL
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UniChem
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| Article
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303857
(4-Amino-7-chloro-1-isobutyl-2-[2-(5-phosphono)fura...)Show SMILES CC(C)Cn1c(nc2c(N)ccc(Cl)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C15H17ClN3O4P/c1-8(2)7-19-14-9(16)3-4-10(17)13(14)18-15(19)11-5-6-12(23-11)24(20,21)22/h3-6,8H,7,17H2,1-2H3,(H2,20,21,22) | PDB
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PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303867
(4-Amino-5-fluoro-7-bromo-1-isobutyl-2-[5-(2-phosph...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)cc(Br)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C15H16BrFN3O4P/c1-7(2)6-20-14-8(16)5-9(17)12(18)13(14)19-15(20)10-3-4-11(24-10)25(21,22)23/h3-5,7H,6,18H2,1-2H3,(H2,21,22,23) | PDB
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PubMed
| n/a | n/a | 2.09E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303877
(4-Amino-7-(4-methylpentyl)-5-fluoro-1-isobutyl-2-[...)Show SMILES CC(C)CCCc1cc(F)c(N)c2nc(-c3ccc(o3)P(O)(O)=O)n(CC(C)C)c12 Show InChI InChI=1S/C21H29FN3O4P/c1-12(2)6-5-7-14-10-15(22)18(23)19-20(14)25(11-13(3)4)21(24-19)16-8-9-17(29-16)30(26,27)28/h8-10,12-13H,5-7,11,23H2,1-4H3,(H2,26,27,28) | PDB
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PubMed
| n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303863
(4-Amino-5-fluoro-1-cyclopropylmethyl-2-[5-(2-phosp...)Show SMILES Nc1c(F)ccc2n(CC3CC3)c(nc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C15H15FN3O4P/c16-9-3-4-10-14(13(9)17)18-15(19(10)7-8-1-2-8)11-5-6-12(23-11)24(20,21)22/h3-6,8H,1-2,7,17H2,(H2,20,21,22) | PDB
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PubMed
| n/a | n/a | 2.18E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303882
(4-Amino-1-ethyl-2-[2-(5-phosphono)furanyl]benzimid...)Show InChI InChI=1S/C13H14N3O4P/c1-2-16-9-5-3-4-8(14)12(9)15-13(16)10-6-7-11(20-10)21(17,18)19/h3-7H,2,14H2,1H3,(H2,17,18,19) | PDB
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PubMed
| n/a | n/a | 2.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303860
(4-Amino-5-fluoro-1-isobutyl-2-[5-(2-phosphono)fura...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)ccc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C15H17FN3O4P/c1-8(2)7-19-10-4-3-9(16)13(17)14(10)18-15(19)11-5-6-12(23-11)24(20,21)22/h3-6,8H,7,17H2,1-2H3,(H2,20,21,22) | PDB
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| Article
PubMed
| n/a | n/a | 2.28E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303897
(4-Amino-1-(4-phenylbenzyl)-2-[2-(5-phosphono)furan...)Show SMILES Nc1cccc2n(Cc3ccc(cc3)-c3ccccc3)c(nc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C24H20N3O4P/c25-19-7-4-8-20-23(19)26-24(21-13-14-22(31-21)32(28,29)30)27(20)15-16-9-11-18(12-10-16)17-5-2-1-3-6-17/h1-14H,15,25H2,(H2,28,29,30) | PDB
UniProtKB/SwissProt
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PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303890
(4-Amino-5-ethyl-1-isobutyl-2-[5-(2-phosphono)furan...)Show SMILES CCc1ccc2n(CC(C)C)c(nc2c1N)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C17H22N3O4P/c1-4-11-5-6-12-16(15(11)18)19-17(20(12)9-10(2)3)13-7-8-14(24-13)25(21,22)23/h5-8,10H,4,9,18H2,1-3H3,(H2,21,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
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UniChem
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| Article
PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303888
(4-Amino-1-cyclohexanemethyl-2-[2-(5-phosphono)fura...)Show SMILES Nc1cccc2n(CC3CCCCC3)c(nc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C18H22N3O4P/c19-13-7-4-8-14-17(13)20-18(15-9-10-16(25-15)26(22,23)24)21(14)11-12-5-2-1-3-6-12/h4,7-10,12H,1-3,5-6,11,19H2,(H2,22,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
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Similars
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PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303862
(4-Amino-5-fluoro-1-(3-pentyl)-2-[5-(2-phosphono)fu...)Show SMILES CCC(CC)n1c(nc2c(N)c(F)ccc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C16H19FN3O4P/c1-3-9(4-2)20-11-6-5-10(17)14(18)15(11)19-16(20)12-7-8-13(24-12)25(21,22)23/h5-9H,3-4,18H2,1-2H3,(H2,21,22,23) | PDB
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| CHEMBL
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PC sid
UniChem
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Similars
| Article
PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303891
(4-Amino-5-propyl-1-isobutyl-2-[5-(2-phosphono)fura...)Show SMILES CCCc1ccc2n(CC(C)C)c(nc2c1N)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C18H24N3O4P/c1-4-5-12-6-7-13-17(16(12)19)20-18(21(13)10-11(2)3)14-8-9-15(25-14)26(22,23)24/h6-9,11H,4-5,10,19H2,1-3H3,(H2,22,23,24) | PDB
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antibodypedia
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| CHEMBL
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PC sid
UniChem
Patents
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| Article
PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303889
(4-Amino-1-cycloheptanemethyl-2-[2-(5-phosphono)fur...)Show SMILES Nc1cccc2n(CC3CCCCCC3)c(nc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C19H24N3O4P/c20-14-8-5-9-15-18(14)21-19(16-10-11-17(26-16)27(23,24)25)22(15)12-13-6-3-1-2-4-7-13/h5,8-11,13H,1-4,6-7,12,20H2,(H2,23,24,25) | PDB
UniProtKB/SwissProt
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Similars
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PubMed
| n/a | n/a | 3.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303900
(4-Amino-1-(3-thienylmethyl)-2-[2-(5-phosphono)fura...)Show SMILES Nc1cccc2n(Cc3ccsc3)c(nc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C16H14N3O4PS/c17-11-2-1-3-12-15(11)18-16(19(12)8-10-6-7-25-9-10)13-4-5-14(23-13)24(20,21)22/h1-7,9H,8,17H2,(H2,20,21,22) | PDB
UniProtKB/SwissProt
antibodypedia
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Similars
| Article
PubMed
| n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303884
(4-Amino-l-isobutyl-2-[2-(5-phosphono)furanyl]benzi...)Show SMILES CC(C)Cn1c(nc2c(N)cccc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C15H18N3O4P/c1-9(2)8-18-11-5-3-4-10(16)14(11)17-15(18)12-6-7-13(22-12)23(19,20)21/h3-7,9H,8,16H2,1-2H3,(H2,19,20,21) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303898
(4-Amino-1-(3-furanylmethyl)-2-[2-(5-phosphono)fura...)Show SMILES Nc1cccc2n(Cc3ccoc3)c(nc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C16H14N3O5P/c17-11-2-1-3-12-15(11)18-16(19(12)8-10-6-7-23-9-10)13-4-5-14(24-13)25(20,21)22/h1-7,9H,8,17H2,(H2,20,21,22) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303894
(4-Amino-1-benzyl-2-[2-(5-phosphono)furanyl]benzimi...)Show SMILES Nc1cccc2n(Cc3ccccc3)c(nc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C18H16N3O4P/c19-13-7-4-8-14-17(13)20-18(15-9-10-16(25-15)26(22,23)24)21(14)11-12-5-2-1-3-6-12/h1-10H,11,19H2,(H2,22,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
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PC sid
UniChem
Similars
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PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303881
(4-Amino-1-methyl-2-[2-(5-phosphono)furanyl]benzimi...)Show InChI InChI=1S/C12H12N3O4P/c1-15-8-4-2-3-7(13)11(8)14-12(15)9-5-6-10(19-9)20(16,17)18/h2-6H,13H2,1H3,(H2,16,17,18) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303896
(4-Amino-1-(3-trifluoromethylbenzyl)-2-[2-(5-phosph...)Show SMILES Nc1cccc2n(Cc3ccc(cc3)C(F)(F)F)c(nc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C19H15F3N3O4P/c20-19(21,22)12-6-4-11(5-7-12)10-25-14-3-1-2-13(23)17(14)24-18(25)15-8-9-16(29-15)30(26,27)28/h1-9H,10,23H2,(H2,26,27,28) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303895
(4-Amino-1-(4-t-butylbenzyl)-2-[2-(5-phosphono)fura...)Show SMILES CC(C)(C)c1ccc(Cn2c(nc3c(N)cccc23)-c2ccc(o2)P(O)(O)=O)cc1 Show InChI InChI=1S/C22H24N3O4P/c1-22(2,3)15-9-7-14(8-10-15)13-25-17-6-4-5-16(23)20(17)24-21(25)18-11-12-19(29-18)30(26,27)28/h4-12H,13,23H2,1-3H3,(H2,26,27,28) | PDB
UniProtKB/SwissProt
antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303869
(4-Amino-5-bromo-6,7-dichloro-2-[5-(2-phosphono)fur...)Show SMILES CC(C)Cn1c(nc2c(N)c(Br)c(Cl)c(Cl)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C15H15BrCl2N3O4P/c1-6(2)5-21-14-11(18)10(17)9(16)12(19)13(14)20-15(21)7-3-4-8(25-7)26(22,23)24/h3-4,6H,5,19H2,1-2H3,(H2,22,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303897
(4-Amino-1-(4-phenylbenzyl)-2-[2-(5-phosphono)furan...)Show SMILES Nc1cccc2n(Cc3ccc(cc3)-c3ccccc3)c(nc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C24H20N3O4P/c25-19-7-4-8-20-23(19)26-24(21-13-14-22(31-21)32(28,29)30)27(20)15-16-9-11-18(12-10-16)17-5-2-1-3-6-17/h1-14H,15,25H2,(H2,28,29,30) | PDB
MMDB
KEGG
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B.MOAD
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UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303900
(4-Amino-1-(3-thienylmethyl)-2-[2-(5-phosphono)fura...)Show SMILES Nc1cccc2n(Cc3ccsc3)c(nc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C16H14N3O4PS/c17-11-2-1-3-12-15(11)18-16(19(12)8-10-6-7-25-9-10)13-4-5-14(23-13)24(20,21)22/h1-7,9H,8,17H2,(H2,20,21,22) | PDB
MMDB
KEGG
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PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303894
(4-Amino-1-benzyl-2-[2-(5-phosphono)furanyl]benzimi...)Show SMILES Nc1cccc2n(Cc3ccccc3)c(nc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C18H16N3O4P/c19-13-7-4-8-14-17(13)20-18(15-9-10-16(25-15)26(22,23)24)21(14)11-12-5-2-1-3-6-12/h1-10H,11,19H2,(H2,22,23,24) | PDB
MMDB
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UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303888
(4-Amino-1-cyclohexanemethyl-2-[2-(5-phosphono)fura...)Show SMILES Nc1cccc2n(CC3CCCCC3)c(nc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C18H22N3O4P/c19-13-7-4-8-14-17(13)20-18(15-9-10-16(25-15)26(22,23)24)21(14)11-12-5-2-1-3-6-12/h4,7-10,12H,1-3,5-6,11,19H2,(H2,22,23,24) | PDB
MMDB
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PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303885
(4-Amino-1-cyclopropylmethyl-2-[2-(5-phosphono)fura...)Show SMILES Nc1cccc2n(CC3CC3)c(nc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C15H16N3O4P/c16-10-2-1-3-11-14(10)17-15(18(11)8-9-4-5-9)12-6-7-13(22-12)23(19,20)21/h1-3,6-7,9H,4-5,8,16H2,(H2,19,20,21) | PDB
MMDB
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| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303899
(4-Amino-1-(3-hydroxybenzyl)-2-[2-(5-phosphono)fura...)Show SMILES Nc1cccc2n(Cc3cccc(O)c3)c(nc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C18H16N3O5P/c19-13-5-2-6-14-17(13)20-18(15-7-8-16(26-15)27(23,24)25)21(14)10-11-3-1-4-12(22)9-11/h1-9,22H,10,19H2,(H2,23,24,25) | PDB
MMDB
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UniChem
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| Article
PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303889
(4-Amino-1-cycloheptanemethyl-2-[2-(5-phosphono)fur...)Show SMILES Nc1cccc2n(CC3CCCCCC3)c(nc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C19H24N3O4P/c20-14-8-5-9-15-18(14)21-19(16-10-11-17(26-16)27(23,24)25)22(15)12-13-6-3-1-2-4-7-13/h5,8-11,13H,1-4,6-7,12,20H2,(H2,23,24,25) | PDB
MMDB
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PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303881
(4-Amino-1-methyl-2-[2-(5-phosphono)furanyl]benzimi...)Show InChI InChI=1S/C12H12N3O4P/c1-15-8-4-2-3-7(13)11(8)14-12(15)9-5-6-10(19-9)20(16,17)18/h2-6H,13H2,1H3,(H2,16,17,18) | PDB
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| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303855
(5-(4-amino-5-hydroxy-1-isobutyl-1H-benzo[d]imidazo...)Show SMILES CC(C)Cn1c(nc2c(N)c(O)ccc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C15H18N3O5P/c1-8(2)7-18-9-3-4-10(19)13(16)14(9)17-15(18)11-5-6-12(23-11)24(20,21)22/h3-6,8,19H,7,16H2,1-2H3,(H2,20,21,22) | PDB
MMDB
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UniChem
Patents
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PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303891
(4-Amino-5-propyl-1-isobutyl-2-[5-(2-phosphono)fura...)Show SMILES CCCc1ccc2n(CC(C)C)c(nc2c1N)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C18H24N3O4P/c1-4-5-12-6-7-13-17(16(12)19)20-18(21(13)10-11(2)3)14-8-9-15(25-14)26(22,23)24/h6-9,11H,4-5,10,19H2,1-3H3,(H2,22,23,24) | PDB
MMDB
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UniChem
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| Article
PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303896
(4-Amino-1-(3-trifluoromethylbenzyl)-2-[2-(5-phosph...)Show SMILES Nc1cccc2n(Cc3ccc(cc3)C(F)(F)F)c(nc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C19H15F3N3O4P/c20-19(21,22)12-6-4-11(5-7-12)10-25-14-3-1-2-13(23)17(14)24-18(25)15-8-9-16(29-15)30(26,27)28/h1-9H,10,23H2,(H2,26,27,28) | PDB
MMDB
KEGG
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UniChem
Similars
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PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303890
(4-Amino-5-ethyl-1-isobutyl-2-[5-(2-phosphono)furan...)Show SMILES CCc1ccc2n(CC(C)C)c(nc2c1N)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C17H22N3O4P/c1-4-11-5-6-12-16(15(11)18)19-17(20(12)9-10(2)3)13-7-8-14(24-13)25(21,22)23/h5-8,10H,4,9,18H2,1-3H3,(H2,21,22,23) | PDB
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| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303898
(4-Amino-1-(3-furanylmethyl)-2-[2-(5-phosphono)fura...)Show SMILES Nc1cccc2n(Cc3ccoc3)c(nc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C16H14N3O5P/c17-11-2-1-3-12-15(11)18-16(19(12)8-10-6-7-23-9-10)13-4-5-14(24-13)25(20,21)22/h1-7,9H,8,17H2,(H2,20,21,22) | PDB
MMDB
KEGG
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UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303895
(4-Amino-1-(4-t-butylbenzyl)-2-[2-(5-phosphono)fura...)Show SMILES CC(C)(C)c1ccc(Cn2c(nc3c(N)cccc23)-c2ccc(o2)P(O)(O)=O)cc1 Show InChI InChI=1S/C22H24N3O4P/c1-22(2,3)15-9-7-14(8-10-15)13-25-17-6-4-5-16(23)20(17)24-21(25)18-11-12-19(29-18)30(26,27)28/h4-12H,13,23H2,1-3H3,(H2,26,27,28) | PDB
MMDB
KEGG
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UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303882
(4-Amino-1-ethyl-2-[2-(5-phosphono)furanyl]benzimid...)Show InChI InChI=1S/C13H14N3O4P/c1-2-16-9-5-3-4-8(14)12(9)15-13(16)10-6-7-11(20-10)21(17,18)19/h3-7H,2,14H2,1H3,(H2,17,18,19) | PDB
MMDB
KEGG
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UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Adenosine deaminase
(Homo sapiens (Human)) | BDBM50303854
(5-(4-amino-7-ethyl-5-fluoro-1-isobutyl-1H-benzo[d]...)Show SMILES CCc1cc(F)c(N)c2nc(-c3ccc(o3)P(O)(O)=O)n(CC(C)C)c12 Show InChI InChI=1S/C17H21FN3O4P/c1-4-10-7-11(18)14(19)15-16(10)21(8-9(2)3)17(20-15)12-5-6-13(25-12)26(22,23)24/h5-7,9H,4,8,19H2,1-3H3,(H2,22,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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| CHEMBL
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PC sid
UniChem
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| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of AMP deaminase AMP binding site |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
Adenosine kinase
(Homo sapiens (Human)) | BDBM50303854
(5-(4-amino-7-ethyl-5-fluoro-1-isobutyl-1H-benzo[d]...)Show SMILES CCc1cc(F)c(N)c2nc(-c3ccc(o3)P(O)(O)=O)n(CC(C)C)c12 Show InChI InChI=1S/C17H21FN3O4P/c1-4-10-7-11(18)14(19)15-16(10)21(8-9(2)3)17(20-15)12-5-6-13(25-12)26(22,23)24/h5-7,9H,4,8,19H2,1-3H3,(H2,22,23,24) | PDB
MMDB
Reactome pathway
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antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of adenosine kinase AMP binding site |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
ATP-dependent 6-phosphofructokinase, muscle type
(Homo sapiens (Human)) | BDBM50303854
(5-(4-amino-7-ethyl-5-fluoro-1-isobutyl-1H-benzo[d]...)Show SMILES CCc1cc(F)c(N)c2nc(-c3ccc(o3)P(O)(O)=O)n(CC(C)C)c12 Show InChI InChI=1S/C17H21FN3O4P/c1-4-10-7-11(18)14(19)15-16(10)21(8-9(2)3)17(20-15)12-5-6-13(25-12)26(22,23)24/h5-7,9H,4,8,19H2,1-3H3,(H2,22,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of phosphofructokinase AMP binding site |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x
BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this
Ligand-Target Pair | |
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