Affinity Data by PubMed id=20063996

PubMed code 20063996

Found 12 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Plasmepsin II (Plasmodium falciparum)	BDBM233139 (2-Nitrobenzohydrazide \| Mr-I-53b) Show SMILES NNC(=O)c1ccccc1[N+]([O-])=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	5.0	n/a
University of Karachi					Assay Description The assay was performed with plasmepsin-II/cathepsin D (1.2 nM) and substrate (malaria FRET-1; 1.0 μM) in 0.1 M sodium acetate buffer pH 5, contai...				J Enzyme Inhib Med Chem 25: 673-8 (2010) Article DOI: 10.3109/14756360903508430 BindingDB Entry DOI: 10.7270/Q29885WX
University of Karachi					More data for this Ligand-Target Pair
Plasmepsin II (Plasmodium falciparum)	BDBM233141 (1,2-Diphenylhydrazine \| Mr-II-10) Show SMILES N(Nc1ccccc1)c1ccccc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.05E+3	n/a	n/a	n/a	n/a	5.0	n/a
University of Karachi					Assay Description The assay was performed with plasmepsin-II/cathepsin D (1.2 nM) and substrate (malaria FRET-1; 1.0 μM) in 0.1 M sodium acetate buffer pH 5, contai...				J Enzyme Inhib Med Chem 25: 673-8 (2010) Article DOI: 10.3109/14756360903508430 BindingDB Entry DOI: 10.7270/Q29885WX
University of Karachi					More data for this Ligand-Target Pair
Plasmepsin II (Plasmodium falciparum)	BDBM233138 (Butanohydrazide \| Mr-I-33) Show SMILES CCCC(=O)NN Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.25E+3	n/a	n/a	n/a	n/a	5.0	n/a
University of Karachi					Assay Description The assay was performed with plasmepsin-II/cathepsin D (1.2 nM) and substrate (malaria FRET-1; 1.0 μM) in 0.1 M sodium acetate buffer pH 5, contai...				J Enzyme Inhib Med Chem 25: 673-8 (2010) Article DOI: 10.3109/14756360903508430 BindingDB Entry DOI: 10.7270/Q29885WX
University of Karachi					More data for this Ligand-Target Pair
Cathepsin D (Homo sapiens (Human))	BDBM233139 (2-Nitrobenzohydrazide \| Mr-I-53b) Show SMILES NNC(=O)c1ccccc1[N+]([O-])=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	5.0	n/a
University of Karachi					Assay Description The assay was performed with plasmepsin-II/cathepsin D (1.2 nM) and substrate (malaria FRET-1; 1.0 μM) in 0.1 M sodium acetate buffer pH 5, contai...				J Enzyme Inhib Med Chem 25: 673-8 (2010) Article DOI: 10.3109/14756360903508430 BindingDB Entry DOI: 10.7270/Q29885WX
University of Karachi					More data for this Ligand-Target Pair
Cathepsin D (Homo sapiens (Human))	BDBM233140 (2-Nitrobenzohydrazide \| Mr-I-179) Show SMILES NNC(=O)C(c1ccccc1)c1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.35E+3	n/a	n/a	n/a	n/a	5.0	n/a
University of Karachi					Assay Description The assay was performed with plasmepsin-II/cathepsin D (1.2 nM) and substrate (malaria FRET-1; 1.0 μM) in 0.1 M sodium acetate buffer pH 5, contai...				J Enzyme Inhib Med Chem 25: 673-8 (2010) Article DOI: 10.3109/14756360903508430 BindingDB Entry DOI: 10.7270/Q29885WX
University of Karachi					More data for this Ligand-Target Pair
Cathepsin D (Homo sapiens (Human))	BDBM233138 (Butanohydrazide \| Mr-I-33) Show SMILES CCCC(=O)NN Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	5.0	n/a
University of Karachi					Assay Description The assay was performed with plasmepsin-II/cathepsin D (1.2 nM) and substrate (malaria FRET-1; 1.0 μM) in 0.1 M sodium acetate buffer pH 5, contai...				J Enzyme Inhib Med Chem 25: 673-8 (2010) Article DOI: 10.3109/14756360903508430 BindingDB Entry DOI: 10.7270/Q29885WX
University of Karachi					More data for this Ligand-Target Pair
Plasmepsin II (Plasmodium falciparum)	BDBM233142 (1,2-Dipyridinylhydrazine \| Mr-II-80) Show SMILES N(Nc1ccncc1)c1ccncc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.45E+3	n/a	n/a	n/a	n/a	5.0	n/a
University of Karachi					Assay Description The assay was performed with plasmepsin-II/cathepsin D (1.2 nM) and substrate (malaria FRET-1; 1.0 μM) in 0.1 M sodium acetate buffer pH 5, contai...				J Enzyme Inhib Med Chem 25: 673-8 (2010) Article DOI: 10.3109/14756360903508430 BindingDB Entry DOI: 10.7270/Q29885WX
University of Karachi					More data for this Ligand-Target Pair
Cathepsin D (Homo sapiens (Human))	BDBM50001676 (CHEMBL3237776 \| Mr-I-27) Show SMILES COc1ccccc1C(=O)NN Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	5.0	n/a
University of Karachi					Assay Description The assay was performed with plasmepsin-II/cathepsin D (1.2 nM) and substrate (malaria FRET-1; 1.0 μM) in 0.1 M sodium acetate buffer pH 5, contai...				J Enzyme Inhib Med Chem 25: 673-8 (2010) Article DOI: 10.3109/14756360903508430 BindingDB Entry DOI: 10.7270/Q29885WX
University of Karachi					More data for this Ligand-Target Pair
Plasmepsin II (Plasmodium falciparum)	BDBM233140 (2-Nitrobenzohydrazide \| Mr-I-179) Show SMILES NNC(=O)C(c1ccccc1)c1ccccc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	5.0	n/a
University of Karachi					Assay Description The assay was performed with plasmepsin-II/cathepsin D (1.2 nM) and substrate (malaria FRET-1; 1.0 μM) in 0.1 M sodium acetate buffer pH 5, contai...				J Enzyme Inhib Med Chem 25: 673-8 (2010) Article DOI: 10.3109/14756360903508430 BindingDB Entry DOI: 10.7270/Q29885WX
University of Karachi					More data for this Ligand-Target Pair
Plasmepsin II (Plasmodium falciparum)	BDBM50001676 (CHEMBL3237776 \| Mr-I-27) Show SMILES COc1ccccc1C(=O)NN Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.65E+3	n/a	n/a	n/a	n/a	5.0	n/a
University of Karachi					Assay Description The assay was performed with plasmepsin-II/cathepsin D (1.2 nM) and substrate (malaria FRET-1; 1.0 μM) in 0.1 M sodium acetate buffer pH 5, contai...				J Enzyme Inhib Med Chem 25: 673-8 (2010) Article DOI: 10.3109/14756360903508430 BindingDB Entry DOI: 10.7270/Q29885WX
University of Karachi					More data for this Ligand-Target Pair
Cathepsin D (Homo sapiens (Human))	BDBM233141 (1,2-Diphenylhydrazine \| Mr-II-10) Show SMILES N(Nc1ccccc1)c1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	5.0	n/a
University of Karachi					Assay Description The assay was performed with plasmepsin-II/cathepsin D (1.2 nM) and substrate (malaria FRET-1; 1.0 μM) in 0.1 M sodium acetate buffer pH 5, contai...				J Enzyme Inhib Med Chem 25: 673-8 (2010) Article DOI: 10.3109/14756360903508430 BindingDB Entry DOI: 10.7270/Q29885WX
University of Karachi					More data for this Ligand-Target Pair
Cathepsin D (Homo sapiens (Human))	BDBM233142 (1,2-Dipyridinylhydrazine \| Mr-II-80) Show SMILES N(Nc1ccncc1)c1ccncc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	5.0	n/a
University of Karachi					Assay Description The assay was performed with plasmepsin-II/cathepsin D (1.2 nM) and substrate (malaria FRET-1; 1.0 μM) in 0.1 M sodium acetate buffer pH 5, contai...				J Enzyme Inhib Med Chem 25: 673-8 (2010) Article DOI: 10.3109/14756360903508430 BindingDB Entry DOI: 10.7270/Q29885WX
University of Karachi					More data for this Ligand-Target Pair

* indicates data uncertainty>20%