Found 36 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50306503
(4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(CC(=O)Nc4ccccc4)C(F)(F)F)cc3F)c2s1 Show InChI InChI=1S/C27H21F4N5O2S/c1-36-14-20(33-15-36)23-12-19-26(39-23)22(9-10-32-19)38-21-8-7-17(11-18(21)28)34-24(27(29,30)31)13-25(37)35-16-5-3-2-4-6-16/h2-12,14-15,24,34H,13H2,1H3,(H,35,37) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description Inhibition of recombinant GST-fused VEGFR2 expressed in baculovirus infected Sf9 cells by DELFIA |
Bioorg Med Chem Lett 20: 848-52 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.099 BindingDB Entry DOI: 10.7270/Q2XW4JWR |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50248557
(CHEMBL465130 | N1-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES CN(C(=O)CC(=O)Nc1ccc(Oc2ccnc3cc(sc23)-c2cn(C)cn2)c(F)c1)c1ccccc1 Show InChI InChI=1S/C27H22FN5O3S/c1-32-15-21(30-16-32)24-13-20-27(37-24)23(10-11-29-20)36-22-9-8-17(12-19(22)28)31-25(34)14-26(35)33(2)18-6-4-3-5-7-18/h3-13,15-16H,14H2,1-2H3,(H,31,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description Inhibition of recombinant GST-fused VEGFR2 expressed in baculovirus infected Sf9 cells by DELFIA |
Bioorg Med Chem Lett 20: 848-52 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.099 BindingDB Entry DOI: 10.7270/Q2XW4JWR |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50306504
(4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES COc1ccccc1NC(=O)CC(Nc1ccc(Oc2ccnc3cc(sc23)-c2cn(C)cn2)c(F)c1)C(F)(F)F Show InChI InChI=1S/C28H23F4N5O3S/c1-37-14-20(34-15-37)24-12-19-27(41-24)23(9-10-33-19)40-21-8-7-16(11-17(21)29)35-25(28(30,31)32)13-26(38)36-18-5-3-4-6-22(18)39-2/h3-12,14-15,25,35H,13H2,1-2H3,(H,36,38) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description Inhibition of recombinant GST-fused VEGFR2 expressed in baculovirus infected Sf9 cells by DELFIA |
Bioorg Med Chem Lett 20: 848-52 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.099 BindingDB Entry DOI: 10.7270/Q2XW4JWR |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50306505
(4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(CC(=O)Nc4ccc(F)cc4)C(F)(F)F)cc3F)c2s1 Show InChI InChI=1S/C27H20F5N5O2S/c1-37-13-20(34-14-37)23-11-19-26(40-23)22(8-9-33-19)39-21-7-6-17(10-18(21)29)35-24(27(30,31)32)12-25(38)36-16-4-2-15(28)3-5-16/h2-11,13-14,24,35H,12H2,1H3,(H,36,38) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description Inhibition of recombinant GST-fused VEGFR2 expressed in baculovirus infected Sf9 cells by DELFIA |
Bioorg Med Chem Lett 20: 848-52 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.099 BindingDB Entry DOI: 10.7270/Q2XW4JWR |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50248556
(CHEMBL464510 | N1-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)CC(=O)Nc4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C26H20FN5O3S/c1-32-14-20(29-15-32)23-12-19-26(36-23)22(9-10-28-19)35-21-8-7-17(11-18(21)27)31-25(34)13-24(33)30-16-5-3-2-4-6-16/h2-12,14-15H,13H2,1H3,(H,30,33)(H,31,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description Inhibition of recombinant GST-fused VEGFR2 expressed in baculovirus infected Sf9 cells by DELFIA |
Bioorg Med Chem Lett 20: 848-52 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.099 BindingDB Entry DOI: 10.7270/Q2XW4JWR |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50306506
(4,4,4-trifluoro-N-(4-fluorophenyl)-3-(4-(2-(1-meth...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(CC(=O)Nc4ccc(F)cc4)C(F)(F)F)cc3)c2s1 Show InChI InChI=1S/C27H21F4N5O2S/c1-36-14-21(33-15-36)23-12-20-26(39-23)22(10-11-32-20)38-19-8-6-17(7-9-19)34-24(27(29,30)31)13-25(37)35-18-4-2-16(28)3-5-18/h2-12,14-15,24,34H,13H2,1H3,(H,35,37) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description Inhibition of recombinant GST-fused VEGFR2 expressed in baculovirus infected Sf9 cells by DELFIA |
Bioorg Med Chem Lett 20: 848-52 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.099 BindingDB Entry DOI: 10.7270/Q2XW4JWR |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50306500
(3-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluoropheny...)Show SMILES COc1cc2nccc(Oc3ccc(NC(CC(=O)Nc4ccccc4)C(F)(F)F)cc3F)c2cc1OC Show InChI InChI=1S/C27H23F4N3O4/c1-36-23-13-18-20(14-24(23)37-2)32-11-10-21(18)38-22-9-8-17(12-19(22)28)33-25(27(29,30)31)15-26(35)34-16-6-4-3-5-7-16/h3-14,25,33H,15H2,1-2H3,(H,34,35) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description Inhibition of recombinant GST-fused VEGFR2 expressed in baculovirus infected Sf9 cells by DELFIA |
Bioorg Med Chem Lett 20: 848-52 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.099 BindingDB Entry DOI: 10.7270/Q2XW4JWR |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248556
(CHEMBL464510 | N1-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)CC(=O)Nc4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C26H20FN5O3S/c1-32-14-20(29-15-32)23-12-19-26(36-23)22(9-10-28-19)35-21-8-7-17(11-18(21)27)31-25(34)13-24(33)30-16-5-3-2-4-6-16/h2-12,14-15H,13H2,1H3,(H,30,33)(H,31,34) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description Inhibition of recombinant GST-fused c-Met expressed in baculovirus infected high five cells by DELFIA |
Bioorg Med Chem Lett 20: 848-52 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.099 BindingDB Entry DOI: 10.7270/Q2XW4JWR |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248557
(CHEMBL465130 | N1-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES CN(C(=O)CC(=O)Nc1ccc(Oc2ccnc3cc(sc23)-c2cn(C)cn2)c(F)c1)c1ccccc1 Show InChI InChI=1S/C27H22FN5O3S/c1-32-15-21(30-16-32)24-13-20-27(37-24)23(10-11-29-20)36-22-9-8-17(12-19(22)28)31-25(34)14-26(35)33(2)18-6-4-3-5-7-18/h3-13,15-16H,14H2,1-2H3,(H,31,34) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description Inhibition of recombinant GST-fused c-Met expressed in baculovirus infected high five cells by DELFIA |
Bioorg Med Chem Lett 20: 848-52 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.099 BindingDB Entry DOI: 10.7270/Q2XW4JWR |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50306502
(CHEMBL612137 | N-(6-(2-fluoro-4-(1,1,1-trifluoro-4...)Show SMILES Fc1cc(NC(CC(=O)Nc2ccccc2)C(F)(F)F)ccc1Oc1cc(NC(=O)N2CCCC2)ncn1 Show InChI InChI=1S/C25H24F4N6O3/c26-18-12-17(32-20(25(27,28)29)13-22(36)33-16-6-2-1-3-7-16)8-9-19(18)38-23-14-21(30-15-31-23)34-24(37)35-10-4-5-11-35/h1-3,6-9,12,14-15,20,32H,4-5,10-11,13H2,(H,33,36)(H,30,31,34,37) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description Inhibition of recombinant GST-fused VEGFR2 expressed in baculovirus infected Sf9 cells by DELFIA |
Bioorg Med Chem Lett 20: 848-52 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.099 BindingDB Entry DOI: 10.7270/Q2XW4JWR |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50306505
(4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(CC(=O)Nc4ccc(F)cc4)C(F)(F)F)cc3F)c2s1 Show InChI InChI=1S/C27H20F5N5O2S/c1-37-13-20(34-14-37)23-11-19-26(40-23)22(8-9-33-19)39-21-7-6-17(10-18(21)29)35-24(27(30,31)32)12-25(38)36-16-4-2-15(28)3-5-16/h2-11,13-14,24,35H,12H2,1H3,(H,36,38) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description Inhibition of recombinant GST-fused c-Met expressed in baculovirus infected high five cells by DELFIA |
Bioorg Med Chem Lett 20: 848-52 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.099 BindingDB Entry DOI: 10.7270/Q2XW4JWR |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50306503
(4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(CC(=O)Nc4ccccc4)C(F)(F)F)cc3F)c2s1 Show InChI InChI=1S/C27H21F4N5O2S/c1-36-14-20(33-15-36)23-12-19-26(39-23)22(9-10-32-19)38-21-8-7-17(11-18(21)28)34-24(27(29,30)31)13-25(37)35-16-5-3-2-4-6-16/h2-12,14-15,24,34H,13H2,1H3,(H,35,37) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description Inhibition of recombinant GST-fused c-Met expressed in baculovirus infected high five cells by DELFIA |
Bioorg Med Chem Lett 20: 848-52 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.099 BindingDB Entry DOI: 10.7270/Q2XW4JWR |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50306506
(4,4,4-trifluoro-N-(4-fluorophenyl)-3-(4-(2-(1-meth...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(CC(=O)Nc4ccc(F)cc4)C(F)(F)F)cc3)c2s1 Show InChI InChI=1S/C27H21F4N5O2S/c1-36-14-21(33-15-36)23-12-20-26(39-23)22(10-11-32-20)38-19-8-6-17(7-9-19)34-24(27(29,30)31)13-25(37)35-18-4-2-16(28)3-5-18/h2-12,14-15,24,34H,13H2,1H3,(H,35,37) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description Inhibition of recombinant GST-fused c-Met expressed in baculovirus infected high five cells by DELFIA |
Bioorg Med Chem Lett 20: 848-52 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.099 BindingDB Entry DOI: 10.7270/Q2XW4JWR |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50306507
(4,4,4-trifluoro-N-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)CC(Nc4ccccc4)C(F)(F)F)cc3F)c2s1 Show InChI InChI=1S/C27H21F4N5O2S/c1-36-14-20(33-15-36)23-12-19-26(39-23)22(9-10-32-19)38-21-8-7-17(11-18(21)28)35-25(37)13-24(27(29,30)31)34-16-5-3-2-4-6-16/h2-12,14-15,24,34H,13H2,1H3,(H,35,37) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description Inhibition of recombinant GST-fused VEGFR2 expressed in baculovirus infected Sf9 cells by DELFIA |
Bioorg Med Chem Lett 20: 848-52 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.099 BindingDB Entry DOI: 10.7270/Q2XW4JWR |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50306499
(CHEMBL600603 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)CC(Nc4ccccc4)C(F)(F)F)cc3F)c2cc1OC Show InChI InChI=1S/C27H23F4N3O4/c1-36-23-13-18-20(14-24(23)37-2)32-11-10-21(18)38-22-9-8-17(12-19(22)28)34-26(35)15-25(27(29,30)31)33-16-6-4-3-5-7-16/h3-14,25,33H,15H2,1-2H3,(H,34,35) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description Inhibition of recombinant GST-fused VEGFR2 expressed in baculovirus infected Sf9 cells by DELFIA |
Bioorg Med Chem Lett 20: 848-52 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.099 BindingDB Entry DOI: 10.7270/Q2XW4JWR |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50306505
(4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(CC(=O)Nc4ccc(F)cc4)C(F)(F)F)cc3F)c2s1 Show InChI InChI=1S/C27H20F5N5O2S/c1-37-13-20(34-14-37)23-11-19-26(40-23)22(8-9-33-19)39-21-7-6-17(10-18(21)29)35-24(27(30,31)32)12-25(38)36-16-4-2-15(28)3-5-16/h2-11,13-14,24,35H,12H2,1H3,(H,36,38) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description Inhibition of TPR-fused Met autophosphorylation expressed in HEK293T cells after 150 mins by ELISA |
Bioorg Med Chem Lett 20: 848-52 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.099 BindingDB Entry DOI: 10.7270/Q2XW4JWR |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50306505
(4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(CC(=O)Nc4ccc(F)cc4)C(F)(F)F)cc3F)c2s1 Show InChI InChI=1S/C27H20F5N5O2S/c1-37-13-20(34-14-37)23-11-19-26(40-23)22(8-9-33-19)39-21-7-6-17(10-18(21)29)35-24(27(30,31)32)12-25(38)36-16-4-2-15(28)3-5-16/h2-11,13-14,24,35H,12H2,1H3,(H,36,38) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description Inhibition of c-MET in human A549 cells by wound healing assay |
Bioorg Med Chem Lett 20: 848-52 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.099 BindingDB Entry DOI: 10.7270/Q2XW4JWR |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50306505
(4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(CC(=O)Nc4ccc(F)cc4)C(F)(F)F)cc3F)c2s1 Show InChI InChI=1S/C27H20F5N5O2S/c1-37-13-20(34-14-37)23-11-19-26(40-23)22(8-9-33-19)39-21-7-6-17(10-18(21)29)35-24(27(30,31)32)12-25(38)36-16-4-2-15(28)3-5-16/h2-11,13-14,24,35H,12H2,1H3,(H,36,38) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description Inhibition of c-MET in human DU145 cells by scattering assay |
Bioorg Med Chem Lett 20: 848-52 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.099 BindingDB Entry DOI: 10.7270/Q2XW4JWR |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50306503
(4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(CC(=O)Nc4ccccc4)C(F)(F)F)cc3F)c2s1 Show InChI InChI=1S/C27H21F4N5O2S/c1-36-14-20(33-15-36)23-12-19-26(39-23)22(9-10-32-19)38-21-8-7-17(11-18(21)28)34-24(27(29,30)31)13-25(37)35-16-5-3-2-4-6-16/h2-12,14-15,24,34H,13H2,1H3,(H,35,37) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description Inhibition of TPR-fused Met autophosphorylation expressed in HEK293T cells after 150 mins by ELISA |
Bioorg Med Chem Lett 20: 848-52 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.099 BindingDB Entry DOI: 10.7270/Q2XW4JWR |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50306499
(CHEMBL600603 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)CC(Nc4ccccc4)C(F)(F)F)cc3F)c2cc1OC Show InChI InChI=1S/C27H23F4N3O4/c1-36-23-13-18-20(14-24(23)37-2)32-11-10-21(18)38-22-9-8-17(12-19(22)28)34-26(35)15-25(27(29,30)31)33-16-6-4-3-5-7-16/h3-14,25,33H,15H2,1-2H3,(H,34,35) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 680 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description Inhibition of recombinant GST-fused c-Met expressed in baculovirus infected high five cells by DELFIA |
Bioorg Med Chem Lett 20: 848-52 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.099 BindingDB Entry DOI: 10.7270/Q2XW4JWR |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50306507
(4,4,4-trifluoro-N-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)CC(Nc4ccccc4)C(F)(F)F)cc3F)c2s1 Show InChI InChI=1S/C27H21F4N5O2S/c1-36-14-20(33-15-36)23-12-19-26(39-23)22(9-10-32-19)38-21-8-7-17(11-18(21)28)35-25(37)13-24(27(29,30)31)34-16-5-3-2-4-6-16/h2-12,14-15,24,34H,13H2,1H3,(H,35,37) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description Inhibition of recombinant GST-fused c-Met expressed in baculovirus infected high five cells by DELFIA |
Bioorg Med Chem Lett 20: 848-52 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.099 BindingDB Entry DOI: 10.7270/Q2XW4JWR |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50306504
(4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES COc1ccccc1NC(=O)CC(Nc1ccc(Oc2ccnc3cc(sc23)-c2cn(C)cn2)c(F)c1)C(F)(F)F Show InChI InChI=1S/C28H23F4N5O3S/c1-37-14-20(34-15-37)24-12-19-27(41-24)23(9-10-33-19)40-21-8-7-16(11-17(21)29)35-25(28(30,31)32)13-26(38)36-18-5-3-4-6-22(18)39-2/h3-12,14-15,25,35H,13H2,1-2H3,(H,36,38) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 840 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description Inhibition of recombinant GST-fused c-Met expressed in baculovirus infected high five cells by DELFIA |
Bioorg Med Chem Lett 20: 848-52 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.099 BindingDB Entry DOI: 10.7270/Q2XW4JWR |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50306498
(CHEMBL600398 | N-(4-(6,7-dimethoxyquinazolin-4-ylo...)Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)CC(Nc4ccccc4)C(F)(F)F)cc3F)c2cc1OC Show InChI InChI=1S/C26H22F4N4O4/c1-36-21-11-17-19(12-22(21)37-2)31-14-32-25(17)38-20-9-8-16(10-18(20)27)34-24(35)13-23(26(28,29)30)33-15-6-4-3-5-7-15/h3-12,14,23,33H,13H2,1-2H3,(H,34,35) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 860 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description Inhibition of recombinant GST-fused VEGFR2 expressed in baculovirus infected Sf9 cells by DELFIA |
Bioorg Med Chem Lett 20: 848-52 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.099 BindingDB Entry DOI: 10.7270/Q2XW4JWR |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50306506
(4,4,4-trifluoro-N-(4-fluorophenyl)-3-(4-(2-(1-meth...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(CC(=O)Nc4ccc(F)cc4)C(F)(F)F)cc3)c2s1 Show InChI InChI=1S/C27H21F4N5O2S/c1-36-14-21(33-15-36)23-12-20-26(39-23)22(10-11-32-20)38-19-8-6-17(7-9-19)34-24(27(29,30)31)13-25(37)35-18-4-2-16(28)3-5-18/h2-12,14-15,24,34H,13H2,1H3,(H,35,37) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 880 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description Inhibition of TPR-fused Met autophosphorylation expressed in HEK293T cells after 150 mins by ELISA |
Bioorg Med Chem Lett 20: 848-52 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.099 BindingDB Entry DOI: 10.7270/Q2XW4JWR |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50306500
(3-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluoropheny...)Show SMILES COc1cc2nccc(Oc3ccc(NC(CC(=O)Nc4ccccc4)C(F)(F)F)cc3F)c2cc1OC Show InChI InChI=1S/C27H23F4N3O4/c1-36-23-13-18-20(14-24(23)37-2)32-11-10-21(18)38-22-9-8-17(12-19(22)28)33-25(27(29,30)31)15-26(35)34-16-6-4-3-5-7-16/h3-14,25,33H,15H2,1-2H3,(H,34,35) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 910 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description Inhibition of recombinant GST-fused c-Met expressed in baculovirus infected high five cells by DELFIA |
Bioorg Med Chem Lett 20: 848-52 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.099 BindingDB Entry DOI: 10.7270/Q2XW4JWR |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50306501
(CHEMBL603082 | N-(6-(2-fluoro-4-(4,4,4-trifluoro-3...)Show SMILES Fc1ccc(NC(CC(=O)Nc2ccc(Oc3cc(NC(=O)N4CCCC4)ncn3)c(F)c2)C(F)(F)F)cc1 Show InChI InChI=1S/C25H23F5N6O3/c26-15-3-5-16(6-4-15)33-20(25(28,29)30)12-22(37)34-17-7-8-19(18(27)11-17)39-23-13-21(31-14-32-23)35-24(38)36-9-1-2-10-36/h3-8,11,13-14,20,33H,1-2,9-10,12H2,(H,34,37)(H,31,32,35,38) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description Inhibition of recombinant GST-fused VEGFR2 expressed in baculovirus infected Sf9 cells by DELFIA |
Bioorg Med Chem Lett 20: 848-52 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.099 BindingDB Entry DOI: 10.7270/Q2XW4JWR |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50306504
(4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES COc1ccccc1NC(=O)CC(Nc1ccc(Oc2ccnc3cc(sc23)-c2cn(C)cn2)c(F)c1)C(F)(F)F Show InChI InChI=1S/C28H23F4N5O3S/c1-37-14-20(34-15-37)24-12-19-27(41-24)23(9-10-33-19)40-21-8-7-16(11-17(21)29)35-25(28(30,31)32)13-26(38)36-18-5-3-4-6-22(18)39-2/h3-12,14-15,25,35H,13H2,1-2H3,(H,36,38) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description Inhibition of TPR-fused Met autophosphorylation expressed in HEK293T cells after 150 mins by ELISA |
Bioorg Med Chem Lett 20: 848-52 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.099 BindingDB Entry DOI: 10.7270/Q2XW4JWR |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50306506
(4,4,4-trifluoro-N-(4-fluorophenyl)-3-(4-(2-(1-meth...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(CC(=O)Nc4ccc(F)cc4)C(F)(F)F)cc3)c2s1 Show InChI InChI=1S/C27H21F4N5O2S/c1-36-14-21(33-15-36)23-12-20-26(39-23)22(10-11-32-20)38-19-8-6-17(7-9-19)34-24(27(29,30)31)13-25(37)35-18-4-2-16(28)3-5-18/h2-12,14-15,24,34H,13H2,1H3,(H,35,37) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description Inhibition of c-MET in human A549 cells by wound healing assay |
Bioorg Med Chem Lett 20: 848-52 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.099 BindingDB Entry DOI: 10.7270/Q2XW4JWR |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50306506
(4,4,4-trifluoro-N-(4-fluorophenyl)-3-(4-(2-(1-meth...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(CC(=O)Nc4ccc(F)cc4)C(F)(F)F)cc3)c2s1 Show InChI InChI=1S/C27H21F4N5O2S/c1-36-14-21(33-15-36)23-12-20-26(39-23)22(10-11-32-20)38-19-8-6-17(7-9-19)34-24(27(29,30)31)13-25(37)35-18-4-2-16(28)3-5-18/h2-12,14-15,24,34H,13H2,1H3,(H,35,37) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description Inhibition of c-MET in human DU145 cells by scattering assay |
Bioorg Med Chem Lett 20: 848-52 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.099 BindingDB Entry DOI: 10.7270/Q2XW4JWR |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50306503
(4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(CC(=O)Nc4ccccc4)C(F)(F)F)cc3F)c2s1 Show InChI InChI=1S/C27H21F4N5O2S/c1-36-14-20(33-15-36)23-12-19-26(39-23)22(9-10-32-19)38-21-8-7-17(11-18(21)28)34-24(27(29,30)31)13-25(37)35-16-5-3-2-4-6-16/h2-12,14-15,24,34H,13H2,1H3,(H,35,37) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description Inhibition of c-MET in human DU145 cells by scattering assay |
Bioorg Med Chem Lett 20: 848-52 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.099 BindingDB Entry DOI: 10.7270/Q2XW4JWR |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50306503
(4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(CC(=O)Nc4ccccc4)C(F)(F)F)cc3F)c2s1 Show InChI InChI=1S/C27H21F4N5O2S/c1-36-14-20(33-15-36)23-12-19-26(39-23)22(9-10-32-19)38-21-8-7-17(11-18(21)28)34-24(27(29,30)31)13-25(37)35-16-5-3-2-4-6-16/h2-12,14-15,24,34H,13H2,1H3,(H,35,37) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description Inhibition of c-MET in human A549 cells by wound healing assay |
Bioorg Med Chem Lett 20: 848-52 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.099 BindingDB Entry DOI: 10.7270/Q2XW4JWR |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50306504
(4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES COc1ccccc1NC(=O)CC(Nc1ccc(Oc2ccnc3cc(sc23)-c2cn(C)cn2)c(F)c1)C(F)(F)F Show InChI InChI=1S/C28H23F4N5O3S/c1-37-14-20(34-15-37)24-12-19-27(41-24)23(9-10-33-19)40-21-8-7-16(11-17(21)29)35-25(28(30,31)32)13-26(38)36-18-5-3-4-6-22(18)39-2/h3-12,14-15,25,35H,13H2,1-2H3,(H,36,38) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description Inhibition of c-MET in human A549 cells by wound healing assay |
Bioorg Med Chem Lett 20: 848-52 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.099 BindingDB Entry DOI: 10.7270/Q2XW4JWR |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50306501
(CHEMBL603082 | N-(6-(2-fluoro-4-(4,4,4-trifluoro-3...)Show SMILES Fc1ccc(NC(CC(=O)Nc2ccc(Oc3cc(NC(=O)N4CCCC4)ncn3)c(F)c2)C(F)(F)F)cc1 Show InChI InChI=1S/C25H23F5N6O3/c26-15-3-5-16(6-4-15)33-20(25(28,29)30)12-22(37)34-17-7-8-19(18(27)11-17)39-23-13-21(31-14-32-23)35-24(38)36-9-1-2-10-36/h3-8,11,13-14,20,33H,1-2,9-10,12H2,(H,34,37)(H,31,32,35,38) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description Inhibition of recombinant GST-fused c-Met expressed in baculovirus infected high five cells by DELFIA |
Bioorg Med Chem Lett 20: 848-52 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.099 BindingDB Entry DOI: 10.7270/Q2XW4JWR |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50306498
(CHEMBL600398 | N-(4-(6,7-dimethoxyquinazolin-4-ylo...)Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)CC(Nc4ccccc4)C(F)(F)F)cc3F)c2cc1OC Show InChI InChI=1S/C26H22F4N4O4/c1-36-21-11-17-19(12-22(21)37-2)31-14-32-25(17)38-20-9-8-16(10-18(20)27)34-24(35)13-23(26(28,29)30)33-15-6-4-3-5-7-15/h3-12,14,23,33H,13H2,1-2H3,(H,34,35) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description Inhibition of recombinant GST-fused c-Met expressed in baculovirus infected high five cells by DELFIA |
Bioorg Med Chem Lett 20: 848-52 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.099 BindingDB Entry DOI: 10.7270/Q2XW4JWR |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50306502
(CHEMBL612137 | N-(6-(2-fluoro-4-(1,1,1-trifluoro-4...)Show SMILES Fc1cc(NC(CC(=O)Nc2ccccc2)C(F)(F)F)ccc1Oc1cc(NC(=O)N2CCCC2)ncn1 Show InChI InChI=1S/C25H24F4N6O3/c26-18-12-17(32-20(25(27,28)29)13-22(36)33-16-6-2-1-3-7-16)8-9-19(18)38-23-14-21(30-15-31-23)34-24(37)35-10-4-5-11-35/h1-3,6-9,12,14-15,20,32H,4-5,10-11,13H2,(H,33,36)(H,30,31,34,37) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description Inhibition of recombinant GST-fused c-Met expressed in baculovirus infected high five cells by DELFIA |
Bioorg Med Chem Lett 20: 848-52 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.099 BindingDB Entry DOI: 10.7270/Q2XW4JWR |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50306504
(4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES COc1ccccc1NC(=O)CC(Nc1ccc(Oc2ccnc3cc(sc23)-c2cn(C)cn2)c(F)c1)C(F)(F)F Show InChI InChI=1S/C28H23F4N5O3S/c1-37-14-20(34-15-37)24-12-19-27(41-24)23(9-10-33-19)40-21-8-7-16(11-17(21)29)35-25(28(30,31)32)13-26(38)36-18-5-3-4-6-22(18)39-2/h3-12,14-15,25,35H,13H2,1-2H3,(H,36,38) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description Inhibition of c-MET in human DU145 cells by scattering assay |
Bioorg Med Chem Lett 20: 848-52 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.099 BindingDB Entry DOI: 10.7270/Q2XW4JWR |
More data for this Ligand-Target Pair | |