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PubMed code 20096577

Compile data set for download or QSAR
Found 42 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50200841
PNG
(CHEMBL220360 | MK-0364 | MK-0634 | N-((2S,3S)-4-(4...)
Show SMILES C[C@H](NC(=O)C(C)(C)Oc1ccc(cn1)C(F)(F)F)[C@@H](Cc1ccc(Cl)cc1)c1cccc(c1)C#N |r|
Show InChI InChI=1S/C27H25ClF3N3O2/c1-17(34-25(35)26(2,3)36-24-12-9-21(16-33-24)27(29,30)31)23(14-18-7-10-22(28)11-8-18)20-6-4-5-19(13-20)15-32/h4-13,16-17,23H,14H2,1-3H3,(H,34,35)/t17-,23+/m0/s1
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n/an/a 0.300n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CB1 receptor


Bioorg Med Chem Lett 20: 1448-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.065
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50314119
PNG
(3-(6-(2-chlorophenyl)-5-(4-chlorophenyl)-2-pivaloy...)
Show SMILES CN(C)C(=O)Nc1c(oc2nc(-c3ccccc3Cl)c(cc12)-c1ccc(Cl)cc1)C(=O)C(C)(C)C
Show InChI InChI=1S/C27H25Cl2N3O3/c1-27(2,3)24(33)23-22(31-26(34)32(4)5)19-14-18(15-10-12-16(28)13-11-15)21(30-25(19)35-23)17-8-6-7-9-20(17)29/h6-14H,1-5H3,(H,31,34)
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n/an/a 0.390n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CB1 receptor


Bioorg Med Chem Lett 20: 1448-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.065
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50314122
PNG
(CHEMBL1091832 | N-(6-(2-chlorophenyl)-5-(4-chlorop...)
Show SMILES CC(C)C(=O)c1oc2nc(-c3ccccc3Cl)c(cc2c1NC(=O)CO)-c1ccc(Cl)cc1
Show InChI InChI=1S/C25H20Cl2N2O4/c1-13(2)23(32)24-22(28-20(31)12-30)18-11-17(14-7-9-15(26)10-8-14)21(29-25(18)33-24)16-5-3-4-6-19(16)27/h3-11,13,30H,12H2,1-2H3,(H,28,31)
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n/an/a 0.400n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CB1 receptor


Bioorg Med Chem Lett 20: 1448-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.065
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50314118
PNG
(CHEMBL1090402 | N-(6-(2-chlorophenyl)-5-(4-chlorop...)
Show SMILES CC(=O)Nc1c(oc2nc(-c3ccccc3Cl)c(cc12)-c1ccc(Cl)cc1)C(=O)C(C)(C)C
Show InChI InChI=1S/C26H22Cl2N2O3/c1-14(31)29-22-19-13-18(15-9-11-16(27)12-10-15)21(17-7-5-6-8-20(17)28)30-25(19)33-23(22)24(32)26(2,3)4/h5-13H,1-4H3,(H,29,31)
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n/an/a 0.580n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CB1 receptor


Bioorg Med Chem Lett 20: 1448-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.065
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50314121
PNG
(CHEMBL1089032 | N-(6-(2-chlorophenyl)-5-(4-chlorop...)
Show SMILES CC(C)(C)C(=O)c1oc2nc(-c3ccccc3Cl)c(cc2c1NC(=O)CO)-c1ccc(Cl)cc1
Show InChI InChI=1S/C26H22Cl2N2O4/c1-26(2,3)24(33)23-22(29-20(32)13-31)18-12-17(14-8-10-15(27)11-9-14)21(30-25(18)34-23)16-6-4-5-7-19(16)28/h4-12,31H,13H2,1-3H3,(H,29,32)
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n/an/a 1.20n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CB1 receptor


Bioorg Med Chem Lett 20: 1448-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.065
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50314120
PNG
(CHEMBL1090404 | N-(6-(2-chlorophenyl)-5-(4-chlorop...)
Show SMILES CNCC(=O)Nc1c(oc2nc(-c3ccccc3Cl)c(cc12)-c1ccc(Cl)cc1)C(=O)C(C)(C)C
Show InChI InChI=1S/C27H25Cl2N3O3/c1-27(2,3)25(34)24-23(31-21(33)14-30-4)19-13-18(15-9-11-16(28)12-10-15)22(32-26(19)35-24)17-7-5-6-8-20(17)29/h5-13,30H,14H2,1-4H3,(H,31,33)
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n/an/a 1.20n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CB1 receptor


Bioorg Med Chem Lett 20: 1448-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.065
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50314113
PNG
(1-(3-amino-6-(2-chlorophenyl)-5-(4-chlorophenyl)fu...)
Show SMILES CC(C)C(=O)c1oc2nc(-c3ccccc3Cl)c(cc2c1N)-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H18Cl2N2O2/c1-12(2)21(28)22-19(26)17-11-16(13-7-9-14(24)10-8-13)20(27-23(17)29-22)15-5-3-4-6-18(15)25/h3-12H,26H2,1-2H3
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n/an/a 1.70n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CB1 receptor


Bioorg Med Chem Lett 20: 1448-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.065
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50259339
PNG
(5-tert-butyl-8-(2-chlorophenyl)-9-(4-chlorophenyl)...)
Show SMILES CC(C)(C)c1nc2nc(-c3ccccc3Cl)c(cc2c2n[nH]c(=O)n12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H19Cl2N5O/c1-24(2,3)22-28-20-17(21-29-30-23(32)31(21)22)12-16(13-8-10-14(25)11-9-13)19(27-20)15-6-4-5-7-18(15)26/h4-12H,1-3H3,(H,30,32)
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n/an/a 1.90n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CB1 receptor


Bioorg Med Chem Lett 20: 1448-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.065
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50314112
PNG
(1-(3-amino-5-(4-chlorophenyl)-6-(2,4-dichloropheny...)
Show SMILES CC(C)C(=O)c1oc2nc(-c3ccc(Cl)cc3Cl)c(cc2c1N)-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H17Cl3N2O2/c1-11(2)21(29)22-19(27)17-10-16(12-3-5-13(24)6-4-12)20(28-23(17)30-22)15-8-7-14(25)9-18(15)26/h3-11H,27H2,1-2H3
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n/an/a 1.90n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CB1 receptor


Bioorg Med Chem Lett 20: 1448-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.065
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50314114
PNG
((3-amino-5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)...)
Show SMILES Nc1c(oc2nc(-c3ccc(Cl)cc3Cl)c(cc12)-c1ccc(Cl)cc1)C(=O)c1ccccc1
Show InChI InChI=1S/C26H15Cl3N2O2/c27-16-8-6-14(7-9-16)19-13-20-22(30)25(24(32)15-4-2-1-3-5-15)33-26(20)31-23(19)18-11-10-17(28)12-21(18)29/h1-13H,30H2
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n/an/a 3.5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CB1 receptor


Bioorg Med Chem Lett 20: 1448-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.065
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50314116
PNG
(1-(3-amino-6-(2-chlorophenyl)-5-(4-chlorophenyl)fu...)
Show SMILES CC(C)(C)C(=O)c1oc2nc(-c3ccccc3Cl)c(cc2c1N)-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H20Cl2N2O2/c1-24(2,3)22(29)21-19(27)17-12-16(13-8-10-14(25)11-9-13)20(28-23(17)30-21)15-6-4-5-7-18(15)26/h4-12H,27H2,1-3H3
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n/an/a 4.30n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CB1 receptor


Bioorg Med Chem Lett 20: 1448-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.065
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50314108
PNG
(CHEMBL1092169 | N-(6-(2-chlorophenyl)-5-(4-chlorop...)
Show SMILES CC(C)(O)C(=O)c1oc2nc(-c3ccccc3Cl)c(cc2c1NC(=O)CO)-c1ccc(Cl)cc1
Show InChI InChI=1S/C25H20Cl2N2O5/c1-25(2,33)23(32)22-21(28-19(31)12-30)17-11-16(13-7-9-14(26)10-8-13)20(29-24(17)34-22)15-5-3-4-6-18(15)27/h3-11,30,33H,12H2,1-2H3,(H,28,31)
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n/an/a 4.30n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CB1 receptor


Bioorg Med Chem Lett 20: 1448-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.065
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50314123
PNG
(CHEMBL1092168 | N-(6-(2-chlorophenyl)-5-(4-chlorop...)
Show SMILES CC(=O)Nc1c(oc2nc(-c3ccccc3Cl)c(cc12)-c1ccc(Cl)cc1)C(=O)C(C)(C)O
Show InChI InChI=1S/C25H20Cl2N2O4/c1-13(30)28-21-18-12-17(14-8-10-15(26)11-9-14)20(16-6-4-5-7-19(16)27)29-24(18)33-22(21)23(31)25(2,3)32/h4-12,32H,1-3H3,(H,28,30)
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n/an/a 5.40n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CB1 receptor


Bioorg Med Chem Lett 20: 1448-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.065
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50314115
PNG
(1-(3-amino-5-(4-chlorophenyl)-6-(2,4-dichloropheny...)
Show SMILES CC(C)(C)C(=O)c1oc2nc(-c3ccc(Cl)cc3Cl)c(cc2c1N)-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H19Cl3N2O2/c1-24(2,3)22(30)21-19(28)17-11-16(12-4-6-13(25)7-5-12)20(29-23(17)31-21)15-9-8-14(26)10-18(15)27/h4-11H,28H2,1-3H3
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n/an/a 5.5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CB1 receptor


Bioorg Med Chem Lett 20: 1448-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.065
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50259140
PNG
(2-tert-butyl-6-(4-chlorophenyl)-7-(2,4-dichlorophe...)
Show SMILES CC(C)(C)c1nc2nc(-c3ccc(Cl)cc3Cl)c(cc2c(=O)[nH]1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H18Cl3N3O/c1-23(2,3)22-28-20-17(21(30)29-22)11-16(12-4-6-13(24)7-5-12)19(27-20)15-9-8-14(25)10-18(15)26/h4-11H,1-3H3,(H,27,28,29,30)
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n/an/a 6n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CB1 receptor


Bioorg Med Chem Lett 20: 1448-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.065
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50176435
PNG
(CHEMBL204232 | N-(3-acetyl-6-(4-chlorophenyl)-7-(2...)
Show SMILES CC(=O)Nc1c(C(C)=O)c(=O)n(C)c2nc(-c3ccc(Cl)cc3Cl)c(cc12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C25H18Cl3N3O3/c1-12(32)21-23(29-13(2)33)19-11-18(14-4-6-15(26)7-5-14)22(30-24(19)31(3)25(21)34)17-9-8-16(27)10-20(17)28/h4-11H,1-3H3,(H,29,33)
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n/an/a 7.5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CB1 receptor


Bioorg Med Chem Lett 20: 1448-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.065
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50314111
PNG
(1-(3-amino-6-(2-chlorophenyl)-5-(4-chlorophenyl)fu...)
Show SMILES CCC(=O)c1oc2nc(-c3ccccc3Cl)c(cc2c1N)-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H16Cl2N2O2/c1-2-18(27)21-19(25)16-11-15(12-7-9-13(23)10-8-12)20(26-22(16)28-21)14-5-3-4-6-17(14)24/h3-11H,2,25H2,1H3
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n/an/a 13n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CB1 receptor


Bioorg Med Chem Lett 20: 1448-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.065
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50314110
PNG
(1-(3-amino-5-(4-chlorophenyl)-6-(2,4-dichloropheny...)
Show SMILES CCC(=O)c1oc2nc(-c3ccc(Cl)cc3Cl)c(cc2c1N)-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H15Cl3N2O2/c1-2-18(28)21-19(26)16-10-15(11-3-5-12(23)6-4-11)20(27-22(16)29-21)14-8-7-13(24)9-17(14)25/h3-10H,2,26H2,1H3
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n/an/a 17n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CB1 receptor


Bioorg Med Chem Lett 20: 1448-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.065
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50314117
PNG
(1-(3-amino-6-(2-chlorophenyl)-5-(4-chlorophenyl)fu...)
Show SMILES CC(C)(O)C(=O)c1oc2nc(-c3ccccc3Cl)c(cc2c1N)-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H18Cl2N2O3/c1-23(2,29)21(28)20-18(26)16-11-15(12-7-9-13(24)10-8-12)19(27-22(16)30-20)14-5-3-4-6-17(14)25/h3-11,29H,26H2,1-2H3
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n/an/a 20n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CB1 receptor


Bioorg Med Chem Lett 20: 1448-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.065
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50314109
PNG
(1-(3-amino-5-(4-chlorophenyl)-6-(2,4-dichloropheny...)
Show SMILES CC(=O)c1oc2nc(-c3ccc(Cl)cc3Cl)c(cc2c1N)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H13Cl3N2O2/c1-10(27)20-18(25)16-9-15(11-2-4-12(22)5-3-11)19(26-21(16)28-20)14-7-6-13(23)8-17(14)24/h2-9H,25H2,1H3
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n/an/a 56n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CB1 receptor


Bioorg Med Chem Lett 20: 1448-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.065
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50314110
PNG
(1-(3-amino-5-(4-chlorophenyl)-6-(2,4-dichloropheny...)
Show SMILES CCC(=O)c1oc2nc(-c3ccc(Cl)cc3Cl)c(cc2c1N)-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H15Cl3N2O2/c1-2-18(28)21-19(26)16-10-15(11-3-5-12(23)6-4-11)20(27-22(16)29-21)14-8-7-13(24)9-17(14)25/h3-10H,2,26H2,1H3
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n/an/a 360n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CB2 receptor


Bioorg Med Chem Lett 20: 1448-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.065
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50314115
PNG
(1-(3-amino-5-(4-chlorophenyl)-6-(2,4-dichloropheny...)
Show SMILES CC(C)(C)C(=O)c1oc2nc(-c3ccc(Cl)cc3Cl)c(cc2c1N)-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H19Cl3N2O2/c1-24(2,3)22(30)21-19(28)17-11-16(12-4-6-13(25)7-5-12)20(29-23(17)31-21)15-9-8-14(26)10-18(15)27/h4-11H,28H2,1-3H3
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n/an/a 440n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CB2 receptor


Bioorg Med Chem Lett 20: 1448-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.065
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50314114
PNG
((3-amino-5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)...)
Show SMILES Nc1c(oc2nc(-c3ccc(Cl)cc3Cl)c(cc12)-c1ccc(Cl)cc1)C(=O)c1ccccc1
Show InChI InChI=1S/C26H15Cl3N2O2/c27-16-8-6-14(7-9-16)19-13-20-22(30)25(24(32)15-4-2-1-3-5-15)33-26(20)31-23(19)18-11-10-17(28)12-21(18)29/h1-13H,30H2
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n/an/a 440n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CB2 receptor


Bioorg Med Chem Lett 20: 1448-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.065
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50314112
PNG
(1-(3-amino-5-(4-chlorophenyl)-6-(2,4-dichloropheny...)
Show SMILES CC(C)C(=O)c1oc2nc(-c3ccc(Cl)cc3Cl)c(cc2c1N)-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H17Cl3N2O2/c1-11(2)21(29)22-19(27)17-10-16(12-3-5-13(24)6-4-12)20(28-23(17)30-22)15-8-7-14(25)9-18(15)26/h3-11H,27H2,1-2H3
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n/an/a 640n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CB2 receptor


Bioorg Med Chem Lett 20: 1448-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.065
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50314111
PNG
(1-(3-amino-6-(2-chlorophenyl)-5-(4-chlorophenyl)fu...)
Show SMILES CCC(=O)c1oc2nc(-c3ccccc3Cl)c(cc2c1N)-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H16Cl2N2O2/c1-2-18(27)21-19(25)16-11-15(12-7-9-13(23)10-8-12)20(26-22(16)28-21)14-5-3-4-6-17(14)24/h3-11H,2,25H2,1H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CB2 receptor


Bioorg Med Chem Lett 20: 1448-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.065
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50314109
PNG
(1-(3-amino-5-(4-chlorophenyl)-6-(2,4-dichloropheny...)
Show SMILES CC(=O)c1oc2nc(-c3ccc(Cl)cc3Cl)c(cc2c1N)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H13Cl3N2O2/c1-10(27)20-18(25)16-9-15(11-2-4-12(22)5-3-11)19(26-21(16)28-20)14-7-6-13(23)8-17(14)24/h2-9H,25H2,1H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CB2 receptor


Bioorg Med Chem Lett 20: 1448-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.065
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50314113
PNG
(1-(3-amino-6-(2-chlorophenyl)-5-(4-chlorophenyl)fu...)
Show SMILES CC(C)C(=O)c1oc2nc(-c3ccccc3Cl)c(cc2c1N)-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H18Cl2N2O2/c1-12(2)21(28)22-19(26)17-11-16(13-7-9-14(24)10-8-13)20(27-23(17)29-22)15-5-3-4-6-18(15)25/h3-12H,26H2,1-2H3
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n/an/a 1.30E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CB2 receptor


Bioorg Med Chem Lett 20: 1448-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.065
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50314116
PNG
(1-(3-amino-6-(2-chlorophenyl)-5-(4-chlorophenyl)fu...)
Show SMILES CC(C)(C)C(=O)c1oc2nc(-c3ccccc3Cl)c(cc2c1N)-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H20Cl2N2O2/c1-24(2,3)22(29)21-19(27)17-12-16(13-8-10-14(25)11-9-13)20(28-23(17)30-21)15-6-4-5-7-18(15)26/h4-12H,27H2,1-3H3
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n/an/a 1.90E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CB2 receptor


Bioorg Med Chem Lett 20: 1448-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.065
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50314119
PNG
(3-(6-(2-chlorophenyl)-5-(4-chlorophenyl)-2-pivaloy...)
Show SMILES CN(C)C(=O)Nc1c(oc2nc(-c3ccccc3Cl)c(cc12)-c1ccc(Cl)cc1)C(=O)C(C)(C)C
Show InChI InChI=1S/C27H25Cl2N3O3/c1-27(2,3)24(33)23-22(31-26(34)32(4)5)19-14-18(15-10-12-16(28)13-11-15)21(30-25(19)35-23)17-8-6-7-9-20(17)29/h6-14H,1-5H3,(H,31,34)
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n/an/a 1.97E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CB2 receptor


Bioorg Med Chem Lett 20: 1448-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.065
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50314118
PNG
(CHEMBL1090402 | N-(6-(2-chlorophenyl)-5-(4-chlorop...)
Show SMILES CC(=O)Nc1c(oc2nc(-c3ccccc3Cl)c(cc12)-c1ccc(Cl)cc1)C(=O)C(C)(C)C
Show InChI InChI=1S/C26H22Cl2N2O3/c1-14(31)29-22-19-13-18(15-9-11-16(27)12-10-15)21(17-7-5-6-8-20(17)28)30-25(19)33-23(22)24(32)26(2,3)4/h5-13H,1-4H3,(H,29,31)
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n/an/a>2.00E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CB2 receptor


Bioorg Med Chem Lett 20: 1448-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.065
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50314117
PNG
(1-(3-amino-6-(2-chlorophenyl)-5-(4-chlorophenyl)fu...)
Show SMILES CC(C)(O)C(=O)c1oc2nc(-c3ccccc3Cl)c(cc2c1N)-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H18Cl2N2O3/c1-23(2,29)21(28)20-18(26)16-11-15(12-7-9-13(24)10-8-12)19(27-22(16)30-20)14-5-3-4-6-17(14)25/h3-11,29H,26H2,1-2H3
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n/an/a 2.10E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CB2 receptor


Bioorg Med Chem Lett 20: 1448-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.065
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50314120
PNG
(CHEMBL1090404 | N-(6-(2-chlorophenyl)-5-(4-chlorop...)
Show SMILES CNCC(=O)Nc1c(oc2nc(-c3ccccc3Cl)c(cc12)-c1ccc(Cl)cc1)C(=O)C(C)(C)C
Show InChI InChI=1S/C27H25Cl2N3O3/c1-27(2,3)25(34)24-23(31-21(33)14-30-4)19-13-18(15-9-11-16(28)12-10-15)22(32-26(19)35-24)17-7-5-6-8-20(17)29/h5-13,30H,14H2,1-4H3,(H,31,33)
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n/an/a 3.30E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CB2 receptor


Bioorg Med Chem Lett 20: 1448-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.065
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50314121
PNG
(CHEMBL1089032 | N-(6-(2-chlorophenyl)-5-(4-chlorop...)
Show SMILES CC(C)(C)C(=O)c1oc2nc(-c3ccccc3Cl)c(cc2c1NC(=O)CO)-c1ccc(Cl)cc1
Show InChI InChI=1S/C26H22Cl2N2O4/c1-26(2,3)24(33)23-22(29-20(32)13-31)18-12-17(14-8-10-15(27)11-9-14)21(30-25(18)34-23)16-6-4-5-7-19(16)28/h4-12,31H,13H2,1-3H3,(H,29,32)
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n/an/a 3.40E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CB2 receptor


Bioorg Med Chem Lett 20: 1448-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.065
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50314122
PNG
(CHEMBL1091832 | N-(6-(2-chlorophenyl)-5-(4-chlorop...)
Show SMILES CC(C)C(=O)c1oc2nc(-c3ccccc3Cl)c(cc2c1NC(=O)CO)-c1ccc(Cl)cc1
Show InChI InChI=1S/C25H20Cl2N2O4/c1-13(2)23(32)24-22(28-20(31)12-30)18-11-17(14-7-9-15(26)10-8-14)21(29-25(18)33-24)16-5-3-4-6-19(16)27/h3-11,13,30H,12H2,1-2H3,(H,28,31)
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n/an/a 5.10E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CB2 receptor


Bioorg Med Chem Lett 20: 1448-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.065
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50314123
PNG
(CHEMBL1092168 | N-(6-(2-chlorophenyl)-5-(4-chlorop...)
Show SMILES CC(=O)Nc1c(oc2nc(-c3ccccc3Cl)c(cc12)-c1ccc(Cl)cc1)C(=O)C(C)(C)O
Show InChI InChI=1S/C25H20Cl2N2O4/c1-13(30)28-21-18-12-17(14-8-10-15(26)11-9-14)20(16-6-4-5-7-19(16)27)29-24(18)33-22(21)23(31)25(2,3)32/h4-12,32H,1-3H3,(H,28,30)
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n/an/a 5.40E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CB2 receptor


Bioorg Med Chem Lett 20: 1448-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.065
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50314108
PNG
(CHEMBL1092169 | N-(6-(2-chlorophenyl)-5-(4-chlorop...)
Show SMILES CC(C)(O)C(=O)c1oc2nc(-c3ccccc3Cl)c(cc2c1NC(=O)CO)-c1ccc(Cl)cc1
Show InChI InChI=1S/C25H20Cl2N2O5/c1-25(2,33)23(32)22-21(28-19(31)12-30)17-11-16(13-7-9-14(26)10-8-13)20(29-24(17)34-22)15-5-3-4-6-18(15)27/h3-11,30,33H,12H2,1-2H3,(H,28,31)
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n/an/a 5.40E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human CB2 receptor


Bioorg Med Chem Lett 20: 1448-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.065
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50314108
PNG
(CHEMBL1092169 | N-(6-(2-chlorophenyl)-5-(4-chlorop...)
Show SMILES CC(C)(O)C(=O)c1oc2nc(-c3ccccc3Cl)c(cc2c1NC(=O)CO)-c1ccc(Cl)cc1
Show InChI InChI=1S/C25H20Cl2N2O5/c1-25(2,33)23(32)22-21(28-19(31)12-30)17-11-16(13-7-9-14(26)10-8-13)20(29-24(17)34-22)15-5-3-4-6-18(15)27/h3-11,30,33H,12H2,1-2H3,(H,28,31)
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n/an/a 6.60E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ERG potassium channel


Bioorg Med Chem Lett 20: 1448-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.065
More data for this
Ligand-Target Pair
Cytochrome P450 1A


(Homo sapiens (Human))
BDBM50314108
PNG
(CHEMBL1092169 | N-(6-(2-chlorophenyl)-5-(4-chlorop...)
Show SMILES CC(C)(O)C(=O)c1oc2nc(-c3ccccc3Cl)c(cc2c1NC(=O)CO)-c1ccc(Cl)cc1
Show InChI InChI=1S/C25H20Cl2N2O5/c1-25(2,33)23(32)22-21(28-19(31)12-30)17-11-16(13-7-9-14(26)10-8-13)20(29-24(17)34-22)15-5-3-4-6-18(15)27/h3-11,30,33H,12H2,1-2H3,(H,28,31)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CYP1A2


Bioorg Med Chem Lett 20: 1448-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.065
More data for this
Ligand-Target Pair
Cytochrome P450 2D6 (2D6)


(Homo sapiens (Human))
BDBM50314108
PNG
(CHEMBL1092169 | N-(6-(2-chlorophenyl)-5-(4-chlorop...)
Show SMILES CC(C)(O)C(=O)c1oc2nc(-c3ccccc3Cl)c(cc2c1NC(=O)CO)-c1ccc(Cl)cc1
Show InChI InChI=1S/C25H20Cl2N2O5/c1-25(2,33)23(32)22-21(28-19(31)12-30)17-11-16(13-7-9-14(26)10-8-13)20(29-24(17)34-22)15-5-3-4-6-18(15)27/h3-11,30,33H,12H2,1-2H3,(H,28,31)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CYP2D6


Bioorg Med Chem Lett 20: 1448-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.065
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50314108
PNG
(CHEMBL1092169 | N-(6-(2-chlorophenyl)-5-(4-chlorop...)
Show SMILES CC(C)(O)C(=O)c1oc2nc(-c3ccccc3Cl)c(cc2c1NC(=O)CO)-c1ccc(Cl)cc1
Show InChI InChI=1S/C25H20Cl2N2O5/c1-25(2,33)23(32)22-21(28-19(31)12-30)17-11-16(13-7-9-14(26)10-8-13)20(29-24(17)34-22)15-5-3-4-6-18(15)27/h3-11,30,33H,12H2,1-2H3,(H,28,31)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CYP3A4


Bioorg Med Chem Lett 20: 1448-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.065
More data for this
Ligand-Target Pair
Cytochrome P450 2C19


(Homo sapiens (Human))
BDBM50314108
PNG
(CHEMBL1092169 | N-(6-(2-chlorophenyl)-5-(4-chlorop...)
Show SMILES CC(C)(O)C(=O)c1oc2nc(-c3ccccc3Cl)c(cc2c1NC(=O)CO)-c1ccc(Cl)cc1
Show InChI InChI=1S/C25H20Cl2N2O5/c1-25(2,33)23(32)22-21(28-19(31)12-30)17-11-16(13-7-9-14(26)10-8-13)20(29-24(17)34-22)15-5-3-4-6-18(15)27/h3-11,30,33H,12H2,1-2H3,(H,28,31)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CYP2C19


Bioorg Med Chem Lett 20: 1448-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.065
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (Human))
BDBM50314108
PNG
(CHEMBL1092169 | N-(6-(2-chlorophenyl)-5-(4-chlorop...)
Show SMILES CC(C)(O)C(=O)c1oc2nc(-c3ccccc3Cl)c(cc2c1NC(=O)CO)-c1ccc(Cl)cc1
Show InChI InChI=1S/C25H20Cl2N2O5/c1-25(2,33)23(32)22-21(28-19(31)12-30)17-11-16(13-7-9-14(26)10-8-13)20(29-24(17)34-22)15-5-3-4-6-18(15)27/h3-11,30,33H,12H2,1-2H3,(H,28,31)
PDB
MMDB

Reactome pathway
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UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CYP2C9


Bioorg Med Chem Lett 20: 1448-52 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.065
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%