BindingDB logo
myBDB logout

PubMed code 20137931

Compile data set for download or QSAR
Found 9 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50312743
PNG
(3-(5-methoxy-6-(4-methoxybenzyloxy)pyridin-3-yloxy...)
Show SMILES COc1ccc(COc2ncc(Oc3nc(cnc3N)-c3cnn(C)c3)cc2OC)cc1
Show InChI InChI=1S/C22H22N6O4/c1-28-12-15(9-26-28)18-11-24-20(23)22(27-18)32-17-8-19(30-3)21(25-10-17)31-13-14-4-6-16(29-2)7-5-14/h4-12H,13H2,1-3H3,(H2,23,24)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 12n/an/an/an/an/an/a



Pfizer Global Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human CSF1R autophosphorylation expressed in HEK293 cells after 1 hr by ELISA

Bioorg Med Chem Lett 20: 1543-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.078
BindingDB Entry DOI: 10.7270/Q2513Z98
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50312742
PNG
(3-((5-methoxy-6-(4-methoxybenzyloxy)pyridin-3-yl)m...)
Show SMILES COc1ccc(COc2ncc(COc3nc(cnc3N)-c3cnn(C)c3)cc2OC)cc1
Show InChI InChI=1S/C23H24N6O4/c1-29-12-17(10-27-29)19-11-25-21(24)23(28-19)33-14-16-8-20(31-3)22(26-9-16)32-13-15-4-6-18(30-2)7-5-15/h4-12H,13-14H2,1-3H3,(H2,24,25)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 30n/an/an/an/an/an/a



Pfizer Global Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human CSF1R autophosphorylation expressed in HEK293 cells after 1 hr by ELISA

Bioorg Med Chem Lett 20: 1543-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.078
BindingDB Entry DOI: 10.7270/Q2513Z98
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50312735
PNG
((S)-(4-(5-amino-6-(2,6-dichlorobenzylamino)pyrazin...)
Show SMILES Nc1ncc(nc1NCc1c(Cl)cccc1Cl)-c1ccc(cc1)C(=O)N1CCC[C@H]1CN1CCCC1 |r|
Show InChI InChI=1S/C27H30Cl2N6O/c28-22-6-3-7-23(29)21(22)15-32-26-25(30)31-16-24(33-26)18-8-10-19(11-9-18)27(36)35-14-4-5-20(35)17-34-12-1-2-13-34/h3,6-11,16,20H,1-2,4-5,12-15,17H2,(H2,30,31)(H,32,33)/t20-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 40n/an/an/an/an/an/a



Pfizer Global Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human CSF1R autophosphorylation expressed in HEK293 cells after 1 hr by ELISA

Bioorg Med Chem Lett 20: 1543-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.078
BindingDB Entry DOI: 10.7270/Q2513Z98
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50312740
PNG
(3-(3-methoxy-4-(4-methoxybenzyloxy)benzyloxy)-5-(1...)
Show SMILES COc1ccc(COc2ccc(COc3nc(cnc3N)-c3cnn(C)c3)cc2OC)cc1
Show InChI InChI=1S/C24H25N5O4/c1-29-13-18(11-27-29)20-12-26-23(25)24(28-20)33-15-17-6-9-21(22(10-17)31-3)32-14-16-4-7-19(30-2)8-5-16/h4-13H,14-15H2,1-3H3,(H2,25,26)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 56n/an/an/an/an/an/a



Pfizer Global Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human CSF1R autophosphorylation expressed in HEK293 cells after 1 hr by ELISA

Bioorg Med Chem Lett 20: 1543-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.078
BindingDB Entry DOI: 10.7270/Q2513Z98
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50312736
PNG
((S)-(4-(5-amino-6-(2,6-dichlorobenzyloxy)pyrazin-2...)
Show SMILES Nc1ncc(nc1OCc1c(Cl)cccc1Cl)-c1ccc(cc1)C(=O)N1CCC[C@H]1CN1CCCC1 |r|
Show InChI InChI=1S/C27H29Cl2N5O2/c28-22-6-3-7-23(29)21(22)17-36-26-25(30)31-15-24(32-26)18-8-10-19(11-9-18)27(35)34-14-4-5-20(34)16-33-12-1-2-13-33/h3,6-11,15,20H,1-2,4-5,12-14,16-17H2,(H2,30,31)/t20-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 57n/an/an/an/an/an/a



Pfizer Global Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human CSF1R autophosphorylation expressed in HEK293 cells after 1 hr by ELISA

Bioorg Med Chem Lett 20: 1543-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.078
BindingDB Entry DOI: 10.7270/Q2513Z98
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50312741
PNG
(3-((4-methoxy-5-(4-methoxybenzyloxy)pyridin-2-yl)m...)
Show SMILES COc1ccc(COc2cnc(COc3nc(cnc3N)-c3cnn(C)c3)cc2OC)cc1
Show InChI InChI=1S/C23H24N6O4/c1-29-12-16(9-27-29)19-10-26-22(24)23(28-19)33-14-17-8-20(31-3)21(11-25-17)32-13-15-4-6-18(30-2)7-5-15/h4-12H,13-14H2,1-3H3,(H2,24,26)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
PDB
Article
PubMed
n/an/a 143n/an/an/an/an/an/a



Pfizer Global Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human CSF1R autophosphorylation expressed in HEK293 cells after 1 hr by ELISA

Bioorg Med Chem Lett 20: 1543-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.078
BindingDB Entry DOI: 10.7270/Q2513Z98
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50312737
PNG
(CHEMBL1088040 | N2-(2,6-dichlorobenzyl)-6-(1-methy...)
Show SMILES Cn1cc(cn1)-c1cnc(N)c(NCc2c(Cl)cccc2Cl)n1
Show InChI InChI=1S/C15H14Cl2N6/c1-23-8-9(5-21-23)13-7-19-14(18)15(22-13)20-6-10-11(16)3-2-4-12(10)17/h2-5,7-8H,6H2,1H3,(H2,18,19)(H,20,22)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 345n/an/an/an/an/an/a



Pfizer Global Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human CSF1R autophosphorylation expressed in HEK293 cells after 1 hr by ELISA

Bioorg Med Chem Lett 20: 1543-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.078
BindingDB Entry DOI: 10.7270/Q2513Z98
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50312738
PNG
(3-(2,6-dichlorobenzyloxy)-5-(1-methyl-1H-pyrazol-4...)
Show SMILES Cn1cc(cn1)-c1cnc(N)c(OCc2c(Cl)cccc2Cl)n1
Show InChI InChI=1S/C15H13Cl2N5O/c1-22-7-9(5-20-22)13-6-19-14(18)15(21-13)23-8-10-11(16)3-2-4-12(10)17/h2-7H,8H2,1H3,(H2,18,19)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.70E+3n/an/an/an/an/an/a



Pfizer Global Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human CSF1R autophosphorylation expressed in HEK293 cells after 1 hr by ELISA

Bioorg Med Chem Lett 20: 1543-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.078
BindingDB Entry DOI: 10.7270/Q2513Z98
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50312739
PNG
(3-(2-chlorobenzyloxy)-5-(1-methyl-1H-pyrazol-4-yl)...)
Show SMILES Cn1cc(cn1)-c1cnc(N)c(OCc2ccccc2Cl)n1
Show InChI InChI=1S/C15H14ClN5O/c1-21-8-11(6-19-21)13-7-18-14(17)15(20-13)22-9-10-4-2-3-5-12(10)16/h2-8H,9H2,1H3,(H2,17,18)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.99E+3n/an/an/an/an/an/a



Pfizer Global Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human CSF1R autophosphorylation expressed in HEK293 cells after 1 hr by ELISA

Bioorg Med Chem Lett 20: 1543-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.078
BindingDB Entry DOI: 10.7270/Q2513Z98
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%