Found 60 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312752
((S)-N1-(5-(isoquinolin-6-yl)-1,3,4-thiadiazol-2-yl...)Show SMILES N[C@H](CNc1nnc(s1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C21H18F3N5S/c22-21(23,24)17-5-1-13(2-6-17)9-18(25)12-27-20-29-28-19(30-20)15-3-4-16-11-26-8-7-14(16)10-15/h1-8,10-11,18H,9,12,25H2,(H,27,29)/t18-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312922
((S)-N1-(5-(isoquinolin-6-yl)thiazol-2-yl)-3-(4-(tr...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C22H19F3N4S/c23-22(24,25)18-5-1-14(2-6-18)9-19(26)12-28-21-29-13-20(30-21)16-3-4-17-11-27-8-7-15(17)10-16/h1-8,10-11,13,19H,9,12,26H2,(H,28,29)/t19-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312934
((S)-6-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2[nH]c(=O)oc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C20H17F3N4O2S/c21-20(22,23)13-4-1-11(2-5-13)7-14(24)9-25-18-26-10-17(30-18)12-3-6-15-16(8-12)29-19(28)27-15/h1-6,8,10,14H,7,9,24H2,(H,25,26)(H,27,28)/t14-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312931
((S)-N1-(5-(1H-indazol-5-yl)thiazol-2-yl)-3-(4-(tri...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2[nH]ncc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C20H18F3N5S/c21-20(22,23)15-4-1-12(2-5-15)7-16(24)10-25-19-26-11-18(29-19)13-3-6-17-14(8-13)9-27-28-17/h1-6,8-9,11,16H,7,10,24H2,(H,25,26)(H,27,28)/t16-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312942
((S)-N1-(5-(3-aminoisoquinolin-6-yl)thiazol-2-yl)-3...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2cnc(N)cc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C22H20F3N5S/c23-22(24,25)17-5-1-13(2-6-17)7-18(26)11-29-21-30-12-19(31-21)14-3-4-15-10-28-20(27)9-16(15)8-14/h1-6,8-10,12,18H,7,11,26H2,(H2,27,28)(H,29,30)/t18-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of AKT1 after 10 mins by [gamma33]ATP assay |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50312922
((S)-N1-(5-(isoquinolin-6-yl)thiazol-2-yl)-3-(4-(tr...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C22H19F3N4S/c23-22(24,25)18-5-1-14(2-6-18)9-19(26)12-28-21-29-13-20(30-21)16-3-4-17-11-27-8-7-15(17)10-16/h1-8,10-11,13,19H,9,12,26H2,(H,28,29)/t19-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50312942
((S)-N1-(5-(3-aminoisoquinolin-6-yl)thiazol-2-yl)-3...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2cnc(N)cc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C22H20F3N5S/c23-22(24,25)17-5-1-13(2-6-17)7-18(26)11-29-21-30-12-19(31-21)14-3-4-15-10-28-20(27)9-16(15)8-14/h1-6,8-10,12,18H,7,11,26H2,(H2,27,28)(H,29,30)/t18-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312936
((S)-6-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)Show SMILES Cn1c2cc(ccc2[nH]c1=O)-c1cnc(NC[C@@H](N)Cc2ccc(cc2)C(F)(F)F)s1 |r| Show InChI InChI=1S/C21H20F3N5OS/c1-29-17-9-13(4-7-16(17)28-20(29)30)18-11-27-19(31-18)26-10-15(25)8-12-2-5-14(6-3-12)21(22,23)24/h2-7,9,11,15H,8,10,25H2,1H3,(H,26,27)(H,28,30)/t15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312924
((S)-N1-(3-(isoquinolin-6-yl)isoxazol-5-yl)-3-(4-(t...)Show SMILES N[C@H](CNc1cc(no1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C22H19F3N4O/c23-22(24,25)18-5-1-14(2-6-18)9-19(26)13-28-21-11-20(29-30-21)16-3-4-17-12-27-8-7-15(17)10-16/h1-8,10-12,19,28H,9,13,26H2/t19-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312933
((S)-5-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2NC(=O)Cc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C21H19F3N4OS/c22-21(23,24)15-4-1-12(2-5-15)7-16(25)10-26-20-27-11-18(30-20)13-3-6-17-14(8-13)9-19(29)28-17/h1-6,8,11,16H,7,9-10,25H2,(H,26,27)(H,28,29)/t16-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312935
((S)-6-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2[nH]c(=O)sc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C20H17F3N4OS2/c21-20(22,23)13-4-1-11(2-5-13)7-14(24)9-25-18-26-10-17(29-18)12-3-6-15-16(8-12)30-19(28)27-15/h1-6,8,10,14H,7,9,24H2,(H,25,26)(H,27,28)/t14-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312943
((S)-N1-(5-(quinazolin-7-yl)thiazol-2-yl)-3-(4-(tri...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2cncnc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C21H18F3N5S/c22-21(23,24)16-5-1-13(2-6-16)7-17(25)10-27-20-28-11-19(30-20)14-3-4-15-9-26-12-29-18(15)8-14/h1-6,8-9,11-12,17H,7,10,25H2,(H,27,28)/t17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of AKT1 after 10 mins by [gamma33]ATP assay |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312925
((R)-4-(3-(isoquinolin-6-yl)isoxazol-5-yl)-1-(4-(tr...)Show SMILES N[C@H](CCc1cc(no1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C23H20F3N3O/c24-23(25,26)19-5-1-15(2-6-19)11-20(27)7-8-21-13-22(29-30-21)17-3-4-18-14-28-10-9-16(18)12-17/h1-6,9-10,12-14,20H,7-8,11,27H2/t20-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50312752
((S)-N1-(5-(isoquinolin-6-yl)-1,3,4-thiadiazol-2-yl...)Show SMILES N[C@H](CNc1nnc(s1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C21H18F3N5S/c22-21(23,24)17-5-1-13(2-6-17)9-18(25)12-27-20-29-28-19(30-20)15-3-4-16-11-26-8-7-14(16)10-15/h1-8,10-11,18H,9,12,25H2,(H,27,29)/t18-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50312932
((S)-N1-(5-(1-amino-1H-benzo[d][1,2,3]triazol-6-yl)...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2nnn(N)c2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C19H18F3N7S/c20-19(21,22)13-4-1-11(2-5-13)7-14(23)9-25-18-26-10-17(30-18)12-3-6-15-16(8-12)29(24)28-27-15/h1-6,8,10,14H,7,9,23-24H2,(H,25,26)/t14-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312932
((S)-N1-(5-(1-amino-1H-benzo[d][1,2,3]triazol-6-yl)...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2nnn(N)c2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C19H18F3N7S/c20-19(21,22)13-4-1-11(2-5-13)7-14(23)9-25-18-26-10-17(30-18)12-3-6-15-16(8-12)29(24)28-27-15/h1-6,8,10,14H,7,9,23-24H2,(H,25,26)/t14-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 77 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312941
((S)-N1-(5-(isoquinolin-6-yl)-1,3,4-oxadiazol-2-yl)...)Show SMILES N[C@H](CNc1nnc(o1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C21H18F3N5O/c22-21(23,24)17-5-1-13(2-6-17)9-18(25)12-27-20-29-28-19(30-20)15-3-4-16-11-26-8-7-14(16)10-15/h1-8,10-11,18H,9,12,25H2,(H,27,29)/t18-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 85 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50312924
((S)-N1-(3-(isoquinolin-6-yl)isoxazol-5-yl)-3-(4-(t...)Show SMILES N[C@H](CNc1cc(no1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C22H19F3N4O/c23-22(24,25)18-5-1-14(2-6-18)9-19(26)13-28-21-11-20(29-30-21)16-3-4-17-12-27-8-7-15(17)10-16/h1-8,10-12,19,28H,9,13,26H2/t19-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 93 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312940
((S)-5-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2C(=O)NCc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C21H19F3N4OS/c22-21(23,24)15-4-1-12(2-5-15)7-16(25)10-27-20-28-11-18(30-20)13-3-6-17-14(8-13)9-26-19(17)29/h1-6,8,11,16H,7,9-10,25H2,(H,26,29)(H,27,28)/t16-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 95 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of AKT1 after 10 mins by [gamma33]ATP assay |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50312933
((S)-5-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2NC(=O)Cc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C21H19F3N4OS/c22-21(23,24)15-4-1-12(2-5-15)7-16(25)10-26-20-27-11-18(30-20)13-3-6-17-14(8-13)9-19(29)28-17/h1-6,8,11,16H,7,9-10,25H2,(H,26,27)(H,28,29)/t16-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of cKIT |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50312925
((R)-4-(3-(isoquinolin-6-yl)isoxazol-5-yl)-1-(4-(tr...)Show SMILES N[C@H](CCc1cc(no1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C23H20F3N3O/c24-23(25,26)19-5-1-15(2-6-19)11-20(27)7-8-21-13-22(29-30-21)17-3-4-18-14-28-10-9-16(18)12-17/h1-6,9-10,12-14,20H,7-8,11,27H2/t20-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 117 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50312943
((S)-N1-(5-(quinazolin-7-yl)thiazol-2-yl)-3-(4-(tri...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2cncnc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C21H18F3N5S/c22-21(23,24)16-5-1-13(2-6-16)7-17(25)10-27-20-28-11-19(30-20)14-3-4-15-9-26-12-29-18(15)8-14/h1-6,8-9,11-12,17H,7,10,25H2,(H,27,28)/t17-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 136 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50312934
((S)-6-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2[nH]c(=O)oc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C20H17F3N4O2S/c21-20(22,23)13-4-1-11(2-5-13)7-14(24)9-25-18-26-10-17(30-18)12-3-6-15-16(8-12)29-19(28)27-15/h1-6,8,10,14H,7,9,24H2,(H,25,26)(H,27,28)/t14-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 138 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312944
((S)-N1-(5-(cinnolin-6-yl)thiazol-2-yl)-3-(4-(trifl...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2nnccc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C21H18F3N5S/c22-21(23,24)16-4-1-13(2-5-16)9-17(25)11-26-20-27-12-19(30-20)15-3-6-18-14(10-15)7-8-28-29-18/h1-8,10,12,17H,9,11,25H2,(H,26,27)/t17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 141 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50312933
((S)-5-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2NC(=O)Cc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C21H19F3N4OS/c22-21(23,24)15-4-1-12(2-5-15)7-16(25)10-26-20-27-11-18(30-20)13-3-6-17-14(8-13)9-19(29)28-17/h1-6,8,11,16H,7,9-10,25H2,(H,26,27)(H,28,29)/t16-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 185 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (Human)) | BDBM50312933
((S)-5-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2NC(=O)Cc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C21H19F3N4OS/c22-21(23,24)15-4-1-12(2-5-15)7-16(25)10-26-20-27-11-18(30-20)13-3-6-17-14(8-13)9-19(29)28-17/h1-6,8,11,16H,7,9-10,25H2,(H,26,27)(H,28,29)/t16-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CDK1 |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312752
((S)-N1-(5-(isoquinolin-6-yl)-1,3,4-thiadiazol-2-yl...)Show SMILES N[C@H](CNc1nnc(s1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C21H18F3N5S/c22-21(23,24)17-5-1-13(2-6-17)9-18(25)12-27-20-29-28-19(30-20)15-3-4-16-11-26-8-7-14(16)10-15/h1-8,10-11,18H,9,12,25H2,(H,27,29)/t18-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50312936
((S)-6-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)Show SMILES Cn1c2cc(ccc2[nH]c1=O)-c1cnc(NC[C@@H](N)Cc2ccc(cc2)C(F)(F)F)s1 |r| Show InChI InChI=1S/C21H20F3N5OS/c1-29-17-9-13(4-7-16(17)28-20(29)30)18-11-27-19(31-18)26-10-15(25)8-12-2-5-14(6-3-12)21(22,23)24/h2-7,9,11,15H,8,10,25H2,1H3,(H,26,27)(H,28,30)/t15-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 276 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50312935
((S)-6-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2[nH]c(=O)sc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C20H17F3N4OS2/c21-20(22,23)13-4-1-11(2-5-13)7-14(24)9-25-18-26-10-17(29-18)12-3-6-15-16(8-12)30-19(28)27-15/h1-6,8,10,14H,7,9,24H2,(H,25,26)(H,27,28)/t14-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 285 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312933
((S)-5-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2NC(=O)Cc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C21H19F3N4OS/c22-21(23,24)15-4-1-12(2-5-15)7-16(25)10-26-20-27-11-18(30-20)13-3-6-17-14(8-13)9-19(29)28-17/h1-6,8,11,16H,7,9-10,25H2,(H,26,27)(H,28,29)/t16-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50312933
((S)-5-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2NC(=O)Cc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C21H19F3N4OS/c22-21(23,24)15-4-1-12(2-5-15)7-16(25)10-26-20-27-11-18(30-20)13-3-6-17-14(8-13)9-19(29)28-17/h1-6,8,11,16H,7,9-10,25H2,(H,26,27)(H,28,29)/t16-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of KDR |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50312941
((S)-N1-(5-(isoquinolin-6-yl)-1,3,4-oxadiazol-2-yl)...)Show SMILES N[C@H](CNc1nnc(o1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C21H18F3N5O/c22-21(23,24)17-5-1-13(2-6-17)9-18(25)12-27-20-29-28-19(30-20)15-3-4-16-11-26-8-7-14(16)10-15/h1-8,10-11,18H,9,12,25H2,(H,27,29)/t18-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 348 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312923
((S)-N1-(2-(isoquinolin-6-yl)thiazol-5-yl)-3-(4-(tr...)Show SMILES N[C@H](CNc1cnc(s1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C22H19F3N4S/c23-22(24,25)18-5-1-14(2-6-18)9-19(26)12-28-20-13-29-21(30-20)16-3-4-17-11-27-8-7-15(17)10-16/h1-8,10-11,13,19,28H,9,12,26H2/t19-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 404 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312922
((S)-N1-(5-(isoquinolin-6-yl)thiazol-2-yl)-3-(4-(tr...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C22H19F3N4S/c23-22(24,25)18-5-1-14(2-6-18)9-19(26)12-28-21-29-13-20(30-21)16-3-4-17-11-27-8-7-15(17)10-16/h1-8,10-11,13,19H,9,12,26H2,(H,28,29)/t19-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 430 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312930
((S)-N1-(5-(3-aminobenzo[d]isoxazol-5-yl)thiazol-2-...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2onc(N)c2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C20H18F3N5OS/c21-20(22,23)13-4-1-11(2-5-13)7-14(24)9-26-19-27-10-17(30-19)12-3-6-16-15(8-12)18(25)28-29-16/h1-6,8,10,14H,7,9,24H2,(H2,25,28)(H,26,27)/t14-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 453 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312934
((S)-6-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2[nH]c(=O)oc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C20H17F3N4O2S/c21-20(22,23)13-4-1-11(2-5-13)7-14(24)9-25-18-26-10-17(30-18)12-3-6-15-16(8-12)29-19(28)27-15/h1-6,8,10,14H,7,9,24H2,(H,25,26)(H,27,28)/t14-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312927
((S)-N1-(5-(1H-indazol-6-yl)thiazol-2-yl)-3-(4-(tri...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2cn[nH]c2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C20H18F3N5S/c21-20(22,23)15-5-1-12(2-6-15)7-16(24)10-25-19-26-11-18(29-19)13-3-4-14-9-27-28-17(14)8-13/h1-6,8-9,11,16H,7,10,24H2,(H,25,26)(H,27,28)/t16-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 613 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312936
((S)-6-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)Show SMILES Cn1c2cc(ccc2[nH]c1=O)-c1cnc(NC[C@@H](N)Cc2ccc(cc2)C(F)(F)F)s1 |r| Show InChI InChI=1S/C21H20F3N5OS/c1-29-17-9-13(4-7-16(17)28-20(29)30)18-11-27-19(31-18)26-10-15(25)8-12-2-5-14(6-3-12)21(22,23)24/h2-7,9,11,15H,8,10,25H2,1H3,(H,26,27)(H,28,30)/t15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 630 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312931
((S)-N1-(5-(1H-indazol-5-yl)thiazol-2-yl)-3-(4-(tri...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2[nH]ncc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C20H18F3N5S/c21-20(22,23)15-4-1-12(2-5-15)7-16(24)10-25-19-26-11-18(29-19)13-3-6-17-14(8-13)9-27-28-17/h1-6,8-9,11,16H,7,10,24H2,(H,25,26)(H,27,28)/t16-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 730 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312942
((S)-N1-(5-(3-aminoisoquinolin-6-yl)thiazol-2-yl)-3...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2cnc(N)cc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C22H20F3N5S/c23-22(24,25)17-5-1-13(2-6-17)7-18(26)11-29-21-30-12-19(31-21)14-3-4-15-10-28-20(27)9-16(15)8-14/h1-6,8-10,12,18H,7,11,26H2,(H2,27,28)(H,29,30)/t18-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 890 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312928
((S)-N1-(5-(1-methyl-1H-indazol-6-yl)thiazol-2-yl)-...)Show SMILES Cn1ncc2ccc(cc12)-c1cnc(NC[C@@H](N)Cc2ccc(cc2)C(F)(F)F)s1 |r| Show InChI InChI=1S/C21H20F3N5S/c1-29-18-9-14(4-5-15(18)10-28-29)19-12-27-20(30-19)26-11-17(25)8-13-2-6-16(7-3-13)21(22,23)24/h2-7,9-10,12,17H,8,11,25H2,1H3,(H,26,27)/t17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 895 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312935
((S)-6-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2[nH]c(=O)sc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C20H17F3N4OS2/c21-20(22,23)13-4-1-11(2-5-13)7-14(24)9-25-18-26-10-17(29-18)12-3-6-15-16(8-12)30-19(28)27-15/h1-6,8,10,14H,7,9,24H2,(H,25,26)(H,27,28)/t14-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 920 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50312938
((S)-7-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2cn[nH]c(=O)c2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C21H18F3N5OS/c22-21(23,24)15-5-1-12(2-6-15)7-16(25)10-26-20-27-11-18(31-20)13-3-4-14-9-28-29-19(30)17(14)8-13/h1-6,8-9,11,16H,7,10,25H2,(H,26,27)(H,29,30)/t16-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312938
((S)-7-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2cn[nH]c(=O)c2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C21H18F3N5OS/c22-21(23,24)15-5-1-12(2-6-15)7-16(25)10-26-20-27-11-18(31-20)13-3-4-14-9-28-29-19(30)17(14)8-13/h1-6,8-9,11,16H,7,10,25H2,(H,26,27)(H,29,30)/t16-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50312927
((S)-N1-(5-(1H-indazol-6-yl)thiazol-2-yl)-3-(4-(tri...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2cn[nH]c2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C20H18F3N5S/c21-20(22,23)15-5-1-12(2-6-15)7-16(24)10-25-19-26-11-18(29-19)13-3-4-14-9-27-28-17(14)8-13/h1-6,8-9,11,16H,7,10,24H2,(H,25,26)(H,27,28)/t16-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50312923
((S)-N1-(2-(isoquinolin-6-yl)thiazol-5-yl)-3-(4-(tr...)Show SMILES N[C@H](CNc1cnc(s1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C22H19F3N4S/c23-22(24,25)18-5-1-14(2-6-18)9-19(26)12-28-20-13-29-21(30-20)16-3-4-17-11-27-8-7-15(17)10-16/h1-8,10-11,13,19,28H,9,12,26H2/t19-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 1.07E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312943
((S)-N1-(5-(quinazolin-7-yl)thiazol-2-yl)-3-(4-(tri...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2cncnc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C21H18F3N5S/c22-21(23,24)16-5-1-13(2-6-16)7-17(25)10-27-20-28-11-19(30-20)14-3-4-15-9-26-12-29-18(15)8-14/h1-6,8-9,11-12,17H,7,10,25H2,(H,27,28)/t17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312926
((R)-4-(3-(isoquinolin-6-yl)-1,2,4-oxadiazol-5-yl)-...)Show SMILES N[C@H](CCc1nc(no1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C22H19F3N4O/c23-22(24,25)18-5-1-14(2-6-18)11-19(26)7-8-20-28-21(29-30-20)16-3-4-17-13-27-10-9-15(17)12-16/h1-6,9-10,12-13,19H,7-8,11,26H2/t19-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50312944
((S)-N1-(5-(cinnolin-6-yl)thiazol-2-yl)-3-(4-(trifl...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2nnccc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C21H18F3N5S/c22-21(23,24)16-4-1-13(2-5-16)9-17(25)11-26-20-27-12-19(30-20)15-3-6-18-14(10-15)7-8-28-29-18/h1-8,10,12,17H,9,11,25H2,(H,26,27)/t17-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50312929
((S)-N1-(5-(3-amino-1-methyl-1H-indazol-6-yl)thiazo...)Show SMILES Cn1nc(N)c2ccc(cc12)-c1cnc(NC[C@@H](N)Cc2ccc(cc2)C(F)(F)F)s1 |r| Show InChI InChI=1S/C21H21F3N6S/c1-30-17-9-13(4-7-16(17)19(26)29-30)18-11-28-20(31-18)27-10-15(25)8-12-2-5-14(6-3-12)21(22,23)24/h2-7,9,11,15H,8,10,25H2,1H3,(H2,26,29)(H,27,28)/t15-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50312930
((S)-N1-(5-(3-aminobenzo[d]isoxazol-5-yl)thiazol-2-...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2onc(N)c2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C20H18F3N5OS/c21-20(22,23)13-4-1-11(2-5-13)7-14(24)9-26-19-27-10-17(30-19)12-3-6-16-15(8-12)18(25)28-29-16/h1-6,8,10,14H,7,9,24H2,(H2,25,28)(H,26,27)/t14-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312929
((S)-N1-(5-(3-amino-1-methyl-1H-indazol-6-yl)thiazo...)Show SMILES Cn1nc(N)c2ccc(cc12)-c1cnc(NC[C@@H](N)Cc2ccc(cc2)C(F)(F)F)s1 |r| Show InChI InChI=1S/C21H21F3N6S/c1-30-17-9-13(4-7-16(17)19(26)29-30)18-11-28-20(31-18)27-10-15(25)8-12-2-5-14(6-3-12)21(22,23)24/h2-7,9,11,15H,8,10,25H2,1H3,(H2,26,29)(H,27,28)/t15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.41E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312939
((S)-4-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc(cc1)C(N)=O)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C20H19F3N4OS/c21-20(22,23)15-7-1-12(2-8-15)9-16(24)10-26-19-27-11-17(29-19)13-3-5-14(6-4-13)18(25)28/h1-8,11,16H,9-10,24H2,(H2,25,28)(H,26,27)/t16-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312937
((S)-6-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2NC(=O)CCc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C22H21F3N4OS/c23-22(24,25)16-5-1-13(2-6-16)9-17(26)11-27-21-28-12-19(31-21)15-3-7-18-14(10-15)4-8-20(30)29-18/h1-3,5-7,10,12,17H,4,8-9,11,26H2,(H,27,28)(H,29,30)/t17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3.32E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312925
((R)-4-(3-(isoquinolin-6-yl)isoxazol-5-yl)-1-(4-(tr...)Show SMILES N[C@H](CCc1cc(no1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C23H20F3N3O/c24-23(25,26)19-5-1-15(2-6-19)11-20(27)7-8-21-13-22(29-30-21)17-3-4-18-14-28-10-9-16(18)12-17/h1-6,9-10,12-14,20H,7-8,11,27H2/t20-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 3.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50312926
((R)-4-(3-(isoquinolin-6-yl)-1,2,4-oxadiazol-5-yl)-...)Show SMILES N[C@H](CCc1nc(no1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C22H19F3N4O/c23-22(24,25)18-5-1-14(2-6-18)11-19(26)7-8-20-28-21(29-30-20)16-3-4-17-13-27-10-9-15(17)12-16/h1-6,9-10,12-13,19H,7-8,11,26H2/t19-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 4.63E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312940
((S)-5-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2C(=O)NCc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C21H19F3N4OS/c22-21(23,24)15-4-1-12(2-5-15)7-16(25)10-27-20-28-11-18(30-20)13-3-6-17-14(8-13)9-26-19(17)29/h1-6,8,11,16H,7,9-10,25H2,(H,26,29)(H,27,28)/t16-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50312940
((S)-5-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2C(=O)NCc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C21H19F3N4OS/c22-21(23,24)15-4-1-12(2-5-15)7-16(25)10-27-20-28-11-18(30-20)13-3-6-17-14(8-13)9-26-19(17)29/h1-6,8,11,16H,7,9-10,25H2,(H,26,29)(H,27,28)/t16-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50312939
((S)-4-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc(cc1)C(N)=O)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C20H19F3N4OS/c21-20(22,23)15-7-1-12(2-8-15)9-16(24)10-26-19-27-11-17(29-19)13-3-5-14(6-4-13)18(25)28/h1-8,11,16H,9-10,24H2,(H2,25,28)(H,26,27)/t16-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50312937
((S)-6-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc2NC(=O)CCc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C22H21F3N4OS/c23-22(24,25)16-5-1-13(2-6-16)9-17(26)11-27-21-28-12-19(31-21)15-3-7-18-14(10-15)4-8-20(30)29-18/h1-3,5-7,10,12,17H,4,8-9,11,26H2,(H,27,28)(H,29,30)/t17-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067
BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this
Ligand-Target Pair | |
Search and Browse
