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PubMed code 20153652

Compile data set for download or QSAR
Found 49 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50130293
PNG
(7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}...)
Show SMILES Clc1cccc(N2CCN(CCCCOc3ccc4CCC(=O)Nc4c3)CC2)c1Cl
Show InChI InChI=1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29)
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 0.400n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5HT1A receptor in Wistar rat hippocampus homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50241119
PNG
(7-(4-Biphenyl-3-ylmethyl-piperazin-1-yl)-3H-benzoo...)
Show SMILES O=c1[nH]c2cccc(N3CCN(Cc4cccc(c4)-c4ccccc4)CC3)c2o1
Show InChI InChI=1S/C24H23N3O2/c28-24-25-21-10-5-11-22(23(21)29-24)27-14-12-26(13-15-27)17-18-6-4-9-20(16-18)19-7-2-1-3-8-19/h1-11,16H,12-15,17H2,(H,25,28)
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 2.20n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Agonist activity at dopamine D2 receptor

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50055810
PNG
(1-Phenyl-4-(2-phenyl-3H-imidazol-4-ylmethyl)-piper...)
Show SMILES C(N1CCN(CC1)c1ccccc1)c1cnc([nH]1)-c1ccccc1
Show InChI InChI=1S/C20H22N4/c1-3-7-17(8-4-1)20-21-15-18(22-20)16-23-11-13-24(14-12-23)19-9-5-2-6-10-19/h1-10,15H,11-14,16H2,(H,21,22)
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 3.60n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Antagonist activity at dopamine D4 receptor

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50130293
PNG
(7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}...)
Show SMILES Clc1cccc(N2CCN(CCCCOc3ccc4CCC(=O)Nc4c3)CC2)c1Cl
Show InChI InChI=1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29)
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 7n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5HT2A receptor in Wistar rat cortex homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50241119
PNG
(7-(4-Biphenyl-3-ylmethyl-piperazin-1-yl)-3H-benzoo...)
Show SMILES O=c1[nH]c2cccc(N3CCN(Cc4cccc(c4)-c4ccccc4)CC3)c2o1
Show InChI InChI=1S/C24H23N3O2/c28-24-25-21-10-5-11-22(23(21)29-24)27-14-12-26(13-15-27)17-18-6-4-9-20(16-18)19-7-2-1-3-8-19/h1-11,16H,12-15,17H2,(H,25,28)
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 9.30n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Agonist activity at 5HT1A receptor

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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 14n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5HT2A receptor in Wistar rat cortex homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50184800
PNG
(1-Phenyl-4-[(1-phenyl-1H-pyrazol-4-yl)methyl]piper...)
Show SMILES C(N1CCN(CC1)c1ccccc1)c1cnn(c1)-c1ccccc1
Show InChI InChI=1S/C20H22N4/c1-3-7-19(8-4-1)23-13-11-22(12-14-23)16-18-15-21-24(17-18)20-9-5-2-6-10-20/h1-10,15,17H,11-14,16H2
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 50n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5HT1A receptor in Wistar rat hippocampus homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50308004
PNG
(1-[(1-(4-Fluorophenyl)-1H-pyrazol-4-yl)methyl]-4-p...)
Show SMILES Fc1ccc(cc1)-n1cc(CN2CCN(CC2)c2ccccc2)cn1
Show InChI InChI=1S/C20H21FN4/c21-18-6-8-20(9-7-18)25-16-17(14-22-25)15-23-10-12-24(13-11-23)19-4-2-1-3-5-19/h1-9,14,16H,10-13,15H2
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 60n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5HT1A receptor in Wistar rat hippocampus homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50308002
PNG
(1-[(1-(4-Chlorophenyl)-1H-pyrazol-4-yl)methyl]-4-p...)
Show SMILES Clc1ccc(cc1)-n1cc(CN2CCN(CC2)c2ccccc2)cn1
Show InChI InChI=1S/C20H21ClN4/c21-18-6-8-20(9-7-18)25-16-17(14-22-25)15-23-10-12-24(13-11-23)19-4-2-1-3-5-19/h1-9,14,16H,10-13,15H2
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 90n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5HT1A receptor in Wistar rat hippocampus homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50184797
PNG
(1-(4-Fluorophenyl)-4-[(1-phenyl-1H-pyrazol-4-yl)me...)
Show SMILES Fc1ccc(cc1)N1CCN(Cc2cnn(c2)-c2ccccc2)CC1
Show InChI InChI=1S/C20H21FN4/c21-18-6-8-19(9-7-18)24-12-10-23(11-13-24)15-17-14-22-25(16-17)20-4-2-1-3-5-20/h1-9,14,16H,10-13,15H2
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 120n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5HT1A receptor in Wistar rat hippocampus homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50308005
PNG
(1-(4-Fluorophenyl)-4-{[1-(4-fluorophenyl)-1H-pyraz...)
Show SMILES Fc1ccc(cc1)N1CCN(Cc2cnn(c2)-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C20H20F2N4/c21-17-1-5-19(6-2-17)25-11-9-24(10-12-25)14-16-13-23-26(15-16)20-7-3-18(22)4-8-20/h1-8,13,15H,9-12,14H2
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 240n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5HT1A receptor in Wistar rat hippocampus homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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 380n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5HT1A receptor in Wistar rat hippocampus homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50184794
PNG
(1-(4-Chlorophenyl)-4-[(1-phenyl-1H-pyrazol-4-yl)me...)
Show SMILES Clc1ccc(cc1)N1CCN(Cc2cnn(c2)-c2ccccc2)CC1
Show InChI InChI=1S/C20H21ClN4/c21-18-6-8-19(9-7-18)24-12-10-23(11-13-24)15-17-14-22-25(16-17)20-4-2-1-3-5-20/h1-9,14,16H,10-13,15H2
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 380n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5HT1A receptor in Wistar rat hippocampus homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50184803
PNG
(1-Phenyl-4-[(1-phenyl-1H-1,2,3-triazol-4-yl)methyl...)
Show SMILES C(N1CCN(CC1)c1ccccc1)c1cn(nn1)-c1ccccc1
Show InChI InChI=1S/C19H21N5/c1-3-7-18(8-4-1)23-13-11-22(12-14-23)15-17-16-24(21-20-17)19-9-5-2-6-10-19/h1-10,16H,11-15H2
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 480n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5HT1A receptor in Wistar rat hippocampus homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50308005
PNG
(1-(4-Fluorophenyl)-4-{[1-(4-fluorophenyl)-1H-pyraz...)
Show SMILES Fc1ccc(cc1)N1CCN(Cc2cnn(c2)-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C20H20F2N4/c21-17-1-5-19(6-2-17)25-11-9-24(10-12-25)14-16-13-23-26(15-16)20-7-3-18(22)4-8-20/h1-8,13,15H,9-12,14H2
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 530n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5HT2A receptor in Wistar rat cortex homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50308006
PNG
(1-(4-Chlorophenyl)-4-{[1-(4-chlorophenyl)-1H-pyraz...)
Show SMILES Clc1ccc(cc1)N1CCN(Cc2cnn(c2)-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C20H20Cl2N4/c21-17-1-5-19(6-2-17)25-11-9-24(10-12-25)14-16-13-23-26(15-16)20-7-3-18(22)4-8-20/h1-8,13,15H,9-12,14H2
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 620n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5HT1A receptor in Wistar rat hippocampus homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50308010
PNG
(1-{[1-(4-Fluorophenyl)-1H-1,2,3-triazol-4-yl]methy...)
Show SMILES Fc1ccc(cc1)-n1cc(CN2CCN(CC2)c2ccccc2)nn1
Show InChI InChI=1S/C19H20FN5/c20-16-6-8-19(9-7-16)25-15-17(21-22-25)14-23-10-12-24(13-11-23)18-4-2-1-3-5-18/h1-9,15H,10-14H2
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 890n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5HT1A receptor in Wistar rat hippocampus homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50184794
PNG
(1-(4-Chlorophenyl)-4-[(1-phenyl-1H-pyrazol-4-yl)me...)
Show SMILES Clc1ccc(cc1)N1CCN(Cc2cnn(c2)-c2ccccc2)CC1
Show InChI InChI=1S/C20H21ClN4/c21-18-6-8-19(9-7-18)24-12-10-23(11-13-24)15-17-14-22-25(16-17)20-4-2-1-3-5-20/h1-9,14,16H,10-13,15H2
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 920n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5HT2A receptor in Wistar rat cortex homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50308004
PNG
(1-[(1-(4-Fluorophenyl)-1H-pyrazol-4-yl)methyl]-4-p...)
Show SMILES Fc1ccc(cc1)-n1cc(CN2CCN(CC2)c2ccccc2)cn1
Show InChI InChI=1S/C20H21FN4/c21-18-6-8-20(9-7-18)25-16-17(14-22-25)15-23-10-12-24(13-11-23)19-4-2-1-3-5-19/h1-9,14,16H,10-13,15H2
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 920n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5HT2A receptor in Wistar rat cortex homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50184797
PNG
(1-(4-Fluorophenyl)-4-[(1-phenyl-1H-pyrazol-4-yl)me...)
Show SMILES Fc1ccc(cc1)N1CCN(Cc2cnn(c2)-c2ccccc2)CC1
Show InChI InChI=1S/C20H21FN4/c21-18-6-8-19(9-7-18)24-12-10-23(11-13-24)15-17-14-22-25(16-17)20-4-2-1-3-5-20/h1-9,14,16H,10-13,15H2
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 1.04E+3n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5HT2A receptor in Wistar rat cortex homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50308003
PNG
(1-((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methy...)
Show SMILES Clc1ccc(cc1)-n1cc(CN2CCN(CC2)c2ccccc2)nn1
Show InChI InChI=1S/C19H20ClN5/c20-16-6-8-19(9-7-16)25-15-17(21-22-25)14-23-10-12-24(13-11-23)18-4-2-1-3-5-18/h1-9,15H,10-14H2
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PubMed
 1.22E+3n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5HT1A receptor in Wistar rat hippocampus homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50308008
PNG
(1-(4-Fluorophenyl)-4-[(1-phenyl-1H-1,2,3-triazol-4...)
Show SMILES Fc1ccc(cc1)N1CCN(Cc2cn(nn2)-c2ccccc2)CC1
Show InChI InChI=1S/C19H20FN5/c20-16-6-8-18(9-7-16)24-12-10-23(11-13-24)14-17-15-25(22-21-17)19-4-2-1-3-5-19/h1-9,15H,10-14H2
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PubMed
 1.50E+3n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5HT1A receptor in Wistar rat hippocampus homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50184800
PNG
(1-Phenyl-4-[(1-phenyl-1H-pyrazol-4-yl)methyl]piper...)
Show SMILES C(N1CCN(CC1)c1ccccc1)c1cnn(c1)-c1ccccc1
Show InChI InChI=1S/C20H22N4/c1-3-7-19(8-4-1)23-13-11-22(12-14-23)16-18-15-21-24(17-18)20-9-5-2-6-10-20/h1-10,15,17H,11-14,16H2
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PubMed
 1.75E+3n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5HT2A receptor in Wistar rat cortex homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50308009
PNG
(1-(4-Chlorophenyl)-4-[(1-phenyl-1H-1,2,3-triazol-4...)
Show SMILES Clc1ccc(cc1)N1CCN(Cc2cn(nn2)-c2ccccc2)CC1
Show InChI InChI=1S/C19H20ClN5/c20-16-6-8-18(9-7-16)24-12-10-23(11-13-24)14-17-15-25(22-21-17)19-4-2-1-3-5-19/h1-9,15H,10-14H2
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 2.06E+3n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5HT2A receptor in Wistar rat cortex homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50308002
PNG
(1-[(1-(4-Chlorophenyl)-1H-pyrazol-4-yl)methyl]-4-p...)
Show SMILES Clc1ccc(cc1)-n1cc(CN2CCN(CC2)c2ccccc2)cn1
Show InChI InChI=1S/C20H21ClN4/c21-18-6-8-20(9-7-18)25-16-17(14-22-25)15-23-10-12-24(13-11-23)19-4-2-1-3-5-19/h1-9,14,16H,10-13,15H2
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PubMed
 2.32E+3n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5HT2A receptor in Wistar rat cortex homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50308015
PNG
(1-{[1-(4-Nitrophenyl)-1H-1,2,3-triazol-4-yl]methyl...)
Show SMILES [O-][N+](=O)c1ccc(cc1)-n1cc(CN2CCN(CC2)c2ccccc2)nn1
Show InChI InChI=1S/C19H20N6O2/c26-25(27)19-8-6-18(7-9-19)24-15-16(20-21-24)14-22-10-12-23(13-11-22)17-4-2-1-3-5-17/h1-9,15H,10-14H2
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 2.78E+3n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5HT1A receptor in Wistar rat hippocampus homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50308011
PNG
(1-(4-Fluorophenyl)-4-{[1-(4-fluorophenyl)-1H-1,2,3...)
Show SMILES Fc1ccc(cc1)N1CCN(Cc2cn(nn2)-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C19H19F2N5/c20-15-1-5-18(6-2-15)25-11-9-24(10-12-25)13-17-14-26(23-22-17)19-7-3-16(21)4-8-19/h1-8,14H,9-13H2
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PubMed
 3.13E+3n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5HT1A receptor in Wistar rat hippocampus homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50308012
PNG
(1-(4-Chlorophenyl)-4-{[1-(4-chlorophenyl)-1H-1,2,3...)
Show SMILES Clc1ccc(cc1)N1CCN(Cc2cn(nn2)-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C19H19Cl2N5/c20-15-1-5-18(6-2-15)25-11-9-24(10-12-25)13-17-14-26(23-22-17)19-7-3-16(21)4-8-19/h1-8,14H,9-13H2
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PubMed
 3.22E+3n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5HT2A receptor in Wistar rat cortex homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50308008
PNG
(1-(4-Fluorophenyl)-4-[(1-phenyl-1H-1,2,3-triazol-4...)
Show SMILES Fc1ccc(cc1)N1CCN(Cc2cn(nn2)-c2ccccc2)CC1
Show InChI InChI=1S/C19H20FN5/c20-16-6-8-18(9-7-16)24-12-10-23(11-13-24)14-17-15-25(22-21-17)19-4-2-1-3-5-19/h1-9,15H,10-14H2
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 3.32E+3n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5HT2A receptor in Wistar rat cortex homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50308017
PNG
(2-Methyl-3-(4-phenylpiperazinylmethyl)imidazo[1,2-...)
Show SMILES Cc1nc2ccccn2c1CN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C19H22N4/c1-16-18(23-10-6-5-9-19(23)20-16)15-21-11-13-22(14-12-21)17-7-3-2-4-8-17/h2-10H,11-15H2,1H3
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PubMed
 4.21E+3n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5HT1A receptor in Wistar rat hippocampus homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50308009
PNG
(1-(4-Chlorophenyl)-4-[(1-phenyl-1H-1,2,3-triazol-4...)
Show SMILES Clc1ccc(cc1)N1CCN(Cc2cn(nn2)-c2ccccc2)CC1
Show InChI InChI=1S/C19H20ClN5/c20-16-6-8-18(9-7-16)24-12-10-23(11-13-24)14-17-15-25(22-21-17)19-4-2-1-3-5-19/h1-9,15H,10-14H2
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 4.25E+3n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5HT1A receptor in Wistar rat hippocampus homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50308007
PNG
(1-{[1-(4-Chlorophenyl)-1H-pyrazol-4-yl]methyl}-4-(...)
Show SMILES COc1ccc(cc1)N1CCN(Cc2cnn(c2)-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C21H23ClN4O/c1-27-21-8-6-19(7-9-21)25-12-10-24(11-13-25)15-17-14-23-26(16-17)20-4-2-18(22)3-5-20/h2-9,14,16H,10-13,15H2,1H3
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>4.44E+3n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5HT1A receptor in Wistar rat hippocampus homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50308012
PNG
(1-(4-Chlorophenyl)-4-{[1-(4-chlorophenyl)-1H-1,2,3...)
Show SMILES Clc1ccc(cc1)N1CCN(Cc2cn(nn2)-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C19H19Cl2N5/c20-15-1-5-18(6-2-15)25-11-9-24(10-12-25)13-17-14-26(23-22-17)19-7-3-16(21)4-8-19/h1-8,14H,9-13H2
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>4.44E+3n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5HT1A receptor in Wistar rat hippocampus homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50308011
PNG
(1-(4-Fluorophenyl)-4-{[1-(4-fluorophenyl)-1H-1,2,3...)
Show SMILES Fc1ccc(cc1)N1CCN(Cc2cn(nn2)-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C19H19F2N5/c20-15-1-5-18(6-2-15)25-11-9-24(10-12-25)13-17-14-26(23-22-17)19-7-3-16(21)4-8-19/h1-8,14H,9-13H2
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PubMed
 4.67E+3n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5HT2A receptor in Wistar rat cortex homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50308018
PNG
(2-Methyl-3-[4-(4-chlorophenyl)piperazinylmethyl]im...)
Show SMILES Cc1nc2ccccn2c1CN1CCN(CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H21ClN4/c1-15-18(24-9-3-2-4-19(24)21-15)14-22-10-12-23(13-11-22)17-7-5-16(20)6-8-17/h2-9H,10-14H2,1H3
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 4.92E+3n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5HT2A receptor in Wistar rat cortex homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50308010
PNG
(1-{[1-(4-Fluorophenyl)-1H-1,2,3-triazol-4-yl]methy...)
Show SMILES Fc1ccc(cc1)-n1cc(CN2CCN(CC2)c2ccccc2)nn1
Show InChI InChI=1S/C19H20FN5/c20-16-6-8-19(9-7-16)25-15-17(21-22-25)14-23-10-12-24(13-11-23)18-4-2-1-3-5-18/h1-9,15H,10-14H2
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PubMed
 5.62E+3n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5HT2A receptor in Wistar rat cortex homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50184803
PNG
(1-Phenyl-4-[(1-phenyl-1H-1,2,3-triazol-4-yl)methyl...)
Show SMILES C(N1CCN(CC1)c1ccccc1)c1cn(nn1)-c1ccccc1
Show InChI InChI=1S/C19H21N5/c1-3-7-18(8-4-1)23-13-11-22(12-14-23)15-17-16-24(21-20-17)19-9-5-2-6-10-19/h1-10,16H,11-15H2
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 5.66E+3n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5HT2A receptor in Wistar rat cortex homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50308006
PNG
(1-(4-Chlorophenyl)-4-{[1-(4-chlorophenyl)-1H-pyraz...)
Show SMILES Clc1ccc(cc1)N1CCN(Cc2cnn(c2)-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C20H20Cl2N4/c21-17-1-5-19(6-2-17)25-11-9-24(10-12-25)14-16-13-23-26(15-16)20-7-3-18(22)4-8-20/h1-8,13,15H,9-12,14H2
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>6.39E+3n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5HT2A receptor in Wistar rat cortex homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50308007
PNG
(1-{[1-(4-Chlorophenyl)-1H-pyrazol-4-yl]methyl}-4-(...)
Show SMILES COc1ccc(cc1)N1CCN(Cc2cnn(c2)-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C21H23ClN4O/c1-27-21-8-6-19(7-9-21)25-12-10-24(11-13-25)15-17-14-23-26(16-17)20-4-2-18(22)3-5-20/h2-9,14,16H,10-13,15H2,1H3
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>6.39E+3n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5HT2A receptor in Wistar rat cortex homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50308013
PNG
(1-(4-Hydroxyphenyl)-4-{[1-(4-chlorophenyl)-1H-1,2,...)
Show SMILES Oc1ccc(cc1)N1CCN(Cc2cn(nn2)-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C19H20ClN5O/c20-15-1-3-18(4-2-15)25-14-16(21-22-25)13-23-9-11-24(12-10-23)17-5-7-19(26)8-6-17/h1-8,14,26H,9-13H2
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 7.98E+3n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5HT1A receptor in Wistar rat hippocampus homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50308003
PNG
(1-((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methy...)
Show SMILES Clc1ccc(cc1)-n1cc(CN2CCN(CC2)c2ccccc2)nn1
Show InChI InChI=1S/C19H20ClN5/c20-16-6-8-19(9-7-16)25-15-17(21-22-25)14-23-10-12-24(13-11-23)18-4-2-1-3-5-18/h1-9,15H,10-14H2
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 1.09E+4n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5HT2A receptor in Wistar rat cortex homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50308017
PNG
(2-Methyl-3-(4-phenylpiperazinylmethyl)imidazo[1,2-...)
Show SMILES Cc1nc2ccccn2c1CN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C19H22N4/c1-16-18(23-10-6-5-9-19(23)20-16)15-21-11-13-22(14-12-21)17-7-3-2-4-8-17/h2-10H,11-15H2,1H3
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 1.16E+4n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5HT2A receptor in Wistar rat cortex homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50308014
PNG
(1-(4-Methoxyphenyl)-4-{[1-(4-chlorophenyl)-1H-1,2,...)
Show SMILES COc1ccc(cc1)N1CCN(Cc2cn(nn2)-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C20H22ClN5O/c1-27-20-8-6-18(7-9-20)25-12-10-24(11-13-25)14-17-15-26(23-22-17)19-4-2-16(21)3-5-19/h2-9,15H,10-14H2,1H3
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>1.33E+4n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5HT1A receptor in Wistar rat hippocampus homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50308018
PNG
(2-Methyl-3-[4-(4-chlorophenyl)piperazinylmethyl]im...)
Show SMILES Cc1nc2ccccn2c1CN1CCN(CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H21ClN4/c1-15-18(24-9-3-2-4-19(24)21-15)14-22-10-12-23(13-11-22)17-7-5-16(20)6-8-17/h2-9H,10-14H2,1H3
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>1.33E+4n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5HT1A receptor in Wistar rat hippocampus homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50308016
PNG
(4-[4-(4-Phenylpiperazinilmetil)-1H-1,2,3-triazol-4...)
Show SMILES CC(=O)Nc1ccc(cc1)-n1cc(CN2CCN(CC2)c2ccccc2)nn1
Show InChI InChI=1S/C21H24N6O/c1-17(28)22-18-7-9-21(10-8-18)27-16-19(23-24-27)15-25-11-13-26(14-12-25)20-5-3-2-4-6-20/h2-10,16H,11-15H2,1H3,(H,22,28)
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>1.33E+4n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5HT1A receptor in Wistar rat hippocampus homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50308013
PNG
(1-(4-Hydroxyphenyl)-4-{[1-(4-chlorophenyl)-1H-1,2,...)
Show SMILES Oc1ccc(cc1)N1CCN(Cc2cn(nn2)-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C19H20ClN5O/c20-15-1-3-18(4-2-15)25-14-16(21-22-25)13-23-9-11-24(12-10-23)17-5-7-19(26)8-6-17/h1-8,14,26H,9-13H2
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>1.92E+4n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5HT2A receptor in Wistar rat cortex homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50308015
PNG
(1-{[1-(4-Nitrophenyl)-1H-1,2,3-triazol-4-yl]methyl...)
Show SMILES [O-][N+](=O)c1ccc(cc1)-n1cc(CN2CCN(CC2)c2ccccc2)nn1
Show InChI InChI=1S/C19H20N6O2/c26-25(27)19-8-6-18(7-9-19)24-15-16(20-21-24)14-22-10-12-23(13-11-22)17-4-2-1-3-5-17/h1-9,15H,10-14H2
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>1.92E+4n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5HT2A receptor in Wistar rat cortex homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50308016
PNG
(4-[4-(4-Phenylpiperazinilmetil)-1H-1,2,3-triazol-4...)
Show SMILES CC(=O)Nc1ccc(cc1)-n1cc(CN2CCN(CC2)c2ccccc2)nn1
Show InChI InChI=1S/C21H24N6O/c1-17(28)22-18-7-9-21(10-8-18)27-16-19(23-24-27)15-25-11-13-26(14-12-25)20-5-3-2-4-6-20/h2-10,16H,11-15H2,1H3,(H,22,28)
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>1.92E+4n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5HT2A receptor in Wistar rat cortex homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50308014
PNG
(1-(4-Methoxyphenyl)-4-{[1-(4-chlorophenyl)-1H-1,2,...)
Show SMILES COc1ccc(cc1)N1CCN(Cc2cn(nn2)-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C20H22ClN5O/c1-27-20-8-6-18(7-9-20)25-12-10-24(11-13-25)14-17-15-26(23-22-17)19-4-2-16(21)3-5-19/h2-9,15H,10-14H2,1H3
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>1.92E+4n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5HT2A receptor in Wistar rat cortex homogenate

Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%