Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human)) | BDBM50308158 (3-(1-(3-(Biphenyl-4-ylamino)-3-oxopropyl)-1H-1,2,3...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | 5.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of SHP2 Src homology-2 domain expressed in Escherichia coli BL21 (DE3) assessed as inhibition of p-nitrophenyl phosphate hydrolysis by Lin... | J Med Chem 53: 2482-93 (2010) Article DOI: 10.1021/jm901645u BindingDB Entry DOI: 10.7270/Q2639PVD | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human)) | BDBM50308158 (3-(1-(3-(Biphenyl-4-ylamino)-3-oxopropyl)-1H-1,2,3...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of SHP2 Src homology-2 domain expressed in Escherichia coli BL21 (DE3) assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH ... | J Med Chem 53: 2482-93 (2010) Article DOI: 10.1021/jm901645u BindingDB Entry DOI: 10.7270/Q2639PVD | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human)) | BDBM50308159 (6-hydroxy-1-methyl-3-(1-(2-(4-morpholinophenylamin...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.80E+3 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of SHP2 Src homology-2 domain expressed in Escherichia coli BL21 (DE3) assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH ... | J Med Chem 53: 2482-93 (2010) Article DOI: 10.1021/jm901645u BindingDB Entry DOI: 10.7270/Q2639PVD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human)) | BDBM50308162 (6-hydroxy-1-methyl-3-(1-(5-oxo-5-(10H-phenothiazin...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.00E+3 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of SHP2 Src homology-2 domain expressed in Escherichia coli BL21 (DE3) assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH ... | J Med Chem 53: 2482-93 (2010) Article DOI: 10.1021/jm901645u BindingDB Entry DOI: 10.7270/Q2639PVD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human)) | BDBM50308161 (3-(1-(2-(benzo[d]thiazol-2-ylamino)-2-oxoethyl)-1H...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9.10E+3 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of SHP2 Src homology-2 domain expressed in Escherichia coli BL21 (DE3) assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH ... | J Med Chem 53: 2482-93 (2010) Article DOI: 10.1021/jm901645u BindingDB Entry DOI: 10.7270/Q2639PVD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human)) | BDBM50308164 (3-(1-(2-(biphenyl-4-ylamino)-2-oxoethyl)-1H-1,2,3-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9.30E+3 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of SHP2 Src homology-2 domain expressed in Escherichia coli BL21 (DE3) assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH ... | J Med Chem 53: 2482-93 (2010) Article DOI: 10.1021/jm901645u BindingDB Entry DOI: 10.7270/Q2639PVD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human)) | BDBM50308160 (3-(1-(2-(9H-fluoren-9-ylamino)-2-oxoethyl)-1H-1,2,...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.04E+4 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of SHP2 Src homology-2 domain expressed in Escherichia coli BL21 (DE3) assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH ... | J Med Chem 53: 2482-93 (2010) Article DOI: 10.1021/jm901645u BindingDB Entry DOI: 10.7270/Q2639PVD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human)) | BDBM50308165 (3-(1-(4-(biphenyl-4-ylamino)-4-oxobutyl)-1H-1,2,3-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of SHP2 Src homology-2 domain expressed in Escherichia coli BL21 (DE3) assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH ... | J Med Chem 53: 2482-93 (2010) Article DOI: 10.1021/jm901645u BindingDB Entry DOI: 10.7270/Q2639PVD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human)) | BDBM50308158 (3-(1-(3-(Biphenyl-4-ylamino)-3-oxopropyl)-1H-1,2,3...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 1.43E+4 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of PTP1B expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometry | J Med Chem 53: 2482-93 (2010) Article DOI: 10.1021/jm901645u BindingDB Entry DOI: 10.7270/Q2639PVD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein phosphatase non-receptor type 6 (Homo sapiens (Human)) | BDBM50308158 (3-(1-(3-(Biphenyl-4-ylamino)-3-oxopropyl)-1H-1,2,3...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 1.57E+4 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of SHP1 expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometry | J Med Chem 53: 2482-93 (2010) Article DOI: 10.1021/jm901645u BindingDB Entry DOI: 10.7270/Q2639PVD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein phosphatase non-receptor type 13 (Homo sapiens (Human)) | BDBM50308158 (3-(1-(3-(Biphenyl-4-ylamino)-3-oxopropyl)-1H-1,2,3...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 2.03E+4 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of FAP1 expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometry | J Med Chem 53: 2482-93 (2010) Article DOI: 10.1021/jm901645u BindingDB Entry DOI: 10.7270/Q2639PVD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein phosphatase non-receptor type 22 (Homo sapiens (Human)) | BDBM50308158 (3-(1-(3-(Biphenyl-4-ylamino)-3-oxopropyl)-1H-1,2,3...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of Lyp expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometry | J Med Chem 53: 2482-93 (2010) Article DOI: 10.1021/jm901645u BindingDB Entry DOI: 10.7270/Q2639PVD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-type tyrosine-protein phosphatase C (Homo sapiens (Human)) | BDBM50308158 (3-(1-(3-(Biphenyl-4-ylamino)-3-oxopropyl)-1H-1,2,3...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 3.00E+4 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of CD45 expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometry | J Med Chem 53: 2482-93 (2010) Article DOI: 10.1021/jm901645u BindingDB Entry DOI: 10.7270/Q2639PVD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Low molecular weight phosphotyrosine protein phosphatase (Homo sapiens (Human)) | BDBM50308158 (3-(1-(3-(Biphenyl-4-ylamino)-3-oxopropyl)-1H-1,2,3...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 3.11E+4 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of LMWPTP expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometry | J Med Chem 53: 2482-93 (2010) Article DOI: 10.1021/jm901645u BindingDB Entry DOI: 10.7270/Q2639PVD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-type tyrosine-protein phosphatase alpha (Homo sapiens (Human)) | BDBM50308158 (3-(1-(3-(Biphenyl-4-ylamino)-3-oxopropyl)-1H-1,2,3...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of PTPalpha expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometry | J Med Chem 53: 2482-93 (2010) Article DOI: 10.1021/jm901645u BindingDB Entry DOI: 10.7270/Q2639PVD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual specificity protein phosphatase CDC14A (Homo sapiens (Human)) | BDBM50308158 (3-(1-(3-(Biphenyl-4-ylamino)-3-oxopropyl)-1H-1,2,3...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of Cdc14A expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometry | J Med Chem 53: 2482-93 (2010) Article DOI: 10.1021/jm901645u BindingDB Entry DOI: 10.7270/Q2639PVD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual specificity protein phosphatase 3 (Homo sapiens (Human)) | BDBM50308158 (3-(1-(3-(Biphenyl-4-ylamino)-3-oxopropyl)-1H-1,2,3...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of VHR expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometry | J Med Chem 53: 2482-93 (2010) Article DOI: 10.1021/jm901645u BindingDB Entry DOI: 10.7270/Q2639PVD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein phosphatase non-receptor type 7 (Homo sapiens (Human)) | BDBM50308158 (3-(1-(3-(Biphenyl-4-ylamino)-3-oxopropyl)-1H-1,2,3...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of HePTP expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometry | J Med Chem 53: 2482-93 (2010) Article DOI: 10.1021/jm901645u BindingDB Entry DOI: 10.7270/Q2639PVD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-type tyrosine-protein phosphatase F (Homo sapiens (Human)) | BDBM50308158 (3-(1-(3-(Biphenyl-4-ylamino)-3-oxopropyl)-1H-1,2,3...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of LAR expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometry | J Med Chem 53: 2482-93 (2010) Article DOI: 10.1021/jm901645u BindingDB Entry DOI: 10.7270/Q2639PVD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human)) | BDBM50308166 (6-hydroxy-1-methyl-3-(1-(3-oxo-3-(phenylamino)prop...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.60E+4 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of SHP2 Src homology-2 domain expressed in Escherichia coli BL21 (DE3) assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH ... | J Med Chem 53: 2482-93 (2010) Article DOI: 10.1021/jm901645u BindingDB Entry DOI: 10.7270/Q2639PVD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human)) | BDBM50308163 (3-Ethynyl-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.12E+5 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of SHP2 Src homology-2 domain expressed in Escherichia coli BL21 (DE3) assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH ... | J Med Chem 53: 2482-93 (2010) Article DOI: 10.1021/jm901645u BindingDB Entry DOI: 10.7270/Q2639PVD | |||||||||||
More data for this Ligand-Target Pair |