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PubMed code 20202837

Compile data set for download or QSAR
Found 51 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50415789
PNG
(CHEMBL1093773)
Show SMILES Cc1nn(C)c2ncc(C(=O)NCc3ccc(Cl)c(c3)C(F)(F)F)c(Cl)c12
Show InChI InChI=1S/C17H13Cl2F3N4O/c1-8-13-14(19)10(7-23-15(13)26(2)25-8)16(27)24-6-9-3-4-12(18)11(5-9)17(20,21)22/h3-5,7H,6H2,1-2H3,(H,24,27)
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n/an/a 63.1n/an/an/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of cortisol-induced renilla luciferase transactiv...

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50415788
PNG
(CHEMBL1093772)
Show SMILES CCn1ncc2c(Cl)c(cnc12)C(=O)NCc1ccc(Cl)c(c1)C(F)(F)F
Show InChI InChI=1S/C17H13Cl2F3N4O/c1-2-26-15-10(8-25-26)14(19)11(7-23-15)16(27)24-6-9-3-4-13(18)12(5-9)17(20,21)22/h3-5,7-8H,2,6H2,1H3,(H,24,27)
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n/an/a 63.1n/an/an/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of cortisol-induced renilla luciferase transactiv...

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50415790
PNG
(CHEMBL1093774 | GSK-1564023A | US10272074, Example...)
Show SMILES Cc1noc(C)c1-c1ccc(CNC(=O)c2cnc3n(C)nc(C)c3c2Cl)cc1
Show InChI InChI=1S/C21H20ClN5O2/c1-11-18-19(22)16(10-23-20(18)27(4)25-11)21(28)24-9-14-5-7-15(8-6-14)17-12(2)26-29-13(17)3/h5-8,10H,9H2,1-4H3,(H,24,28)
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n/an/a 100n/an/an/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of cortisol-induced renilla luciferase transactiv...

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50415791
PNG
(CHEMBL1089404)
Show SMILES CCn1ncc2c(Cl)c(cnc12)C(=O)NCc1cc(C)cc(C)c1
Show InChI InChI=1S/C18H19ClN4O/c1-4-23-17-14(10-22-23)16(19)15(9-20-17)18(24)21-8-13-6-11(2)5-12(3)7-13/h5-7,9-10H,4,8H2,1-3H3,(H,21,24)
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n/an/a 158n/an/an/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of cortisol-induced renilla luciferase transactiv...

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50415792
PNG
(CHEMBL1089743)
Show SMILES COc1cccc(c1)-c1ccccc1CNC(=O)c1cnc2n(C)nc(C)c2c1Cl
Show InChI InChI=1S/C23H21ClN4O2/c1-14-20-21(24)19(13-25-22(20)28(2)27-14)23(29)26-12-16-7-4-5-10-18(16)15-8-6-9-17(11-15)30-3/h4-11,13H,12H2,1-3H3,(H,26,29)
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n/an/a 200n/an/an/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of cortisol-induced renilla luciferase transactiv...

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50415793
PNG
(CHEMBL1089744)
Show SMILES Cc1nn(C)c2ncc(C(=O)NCc3cc(C)cc(C)c3)c(Cl)c12
Show InChI InChI=1S/C18H19ClN4O/c1-10-5-11(2)7-13(6-10)8-21-18(24)14-9-20-17-15(16(14)19)12(3)22-23(17)4/h5-7,9H,8H2,1-4H3,(H,21,24)
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n/an/a 200n/an/an/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of cortisol-induced renilla luciferase transactiv...

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50415794
PNG
(CHEMBL1093602 | GSK-325971A)
Show SMILES CCn1ncc2c(Cl)c(cnc12)C(=O)NCc1ccc(C)cc1C
Show InChI InChI=1S/C18H19ClN4O/c1-4-23-17-14(10-22-23)16(19)15(9-20-17)18(24)21-8-13-6-5-11(2)7-12(13)3/h5-7,9-10H,4,8H2,1-3H3,(H,21,24)
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n/an/a 200n/an/an/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of cortisol-induced renilla luciferase transactiv...

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50415796
PNG
(CHEMBL1089350)
Show SMILES CCc1nn(C)c2ncc(C(=O)NCC3Cc4ccccc4C3)c(Cl)c12
Show InChI InChI=1S/C20H21ClN4O/c1-3-16-17-18(21)15(11-22-19(17)25(2)24-16)20(26)23-10-12-8-13-6-4-5-7-14(13)9-12/h4-7,11-12H,3,8-10H2,1-2H3,(H,23,26)
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n/an/a 251n/an/an/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of cortisol-induced renilla luciferase transactiv...

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50415808
PNG
(CHEMBL1091054)
Show SMILES Cc1noc(C)c1-c1ccc(CNC(=O)c2cnc3n(Cc4ccccn4)nc(C)c3c2Cl)cc1
Show InChI InChI=1S/C26H23ClN6O2/c1-15-23-24(27)21(13-29-25(23)33(31-15)14-20-6-4-5-11-28-20)26(34)30-12-18-7-9-19(10-8-18)22-16(2)32-35-17(22)3/h4-11,13H,12,14H2,1-3H3,(H,30,34)
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n/an/a 251n/an/an/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of cortisol-induced renilla luciferase transactiv...

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50415806
PNG
(CHEMBL1094035)
Show SMILES CC(C)n1nc(C)c2c(Cl)c(cnc12)C(=O)NCc1ccc(cc1)-c1c(C)noc1C
Show InChI InChI=1S/C23H24ClN5O2/c1-12(2)29-22-20(13(3)27-29)21(24)18(11-25-22)23(30)26-10-16-6-8-17(9-7-16)19-14(4)28-31-15(19)5/h6-9,11-12H,10H2,1-5H3,(H,26,30)
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n/an/a 251n/an/an/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of cortisol-induced renilla luciferase transactiv...

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50415807
PNG
(CHEMBL1090973)
Show SMILES CCCn1nc(C)c2c(Cl)c(cnc12)C(=O)NCc1ccc(cc1)-c1c(C)noc1C
Show InChI InChI=1S/C23H24ClN5O2/c1-5-10-29-22-20(13(2)27-29)21(24)18(12-25-22)23(30)26-11-16-6-8-17(9-7-16)19-14(3)28-31-15(19)4/h6-9,12H,5,10-11H2,1-4H3,(H,26,30)
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n/an/a 251n/an/an/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of cortisol-induced renilla luciferase transactiv...

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50415795
PNG
(CHEMBL1089745)
Show SMILES CCn1ncc2c(Cl)c(cnc12)C(=O)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C16H14Cl2N4O/c1-2-22-15-12(9-21-22)14(18)13(8-19-15)16(23)20-7-10-3-5-11(17)6-4-10/h3-6,8-9H,2,7H2,1H3,(H,20,23)
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n/an/a 251n/an/an/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of cortisol-induced renilla luciferase transactiv...

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50415810
PNG
(CHEMBL1091440 | US10272074, Example 30)
Show SMILES Cc1noc(C)c1-c1ccc(CNC(=O)c2cnc3n(nc(C)c3c2Cl)-c2ccccc2)cc1
Show InChI InChI=1S/C26H22ClN5O2/c1-15-23-24(27)21(14-28-25(23)32(30-15)20-7-5-4-6-8-20)26(33)29-13-18-9-11-19(12-10-18)22-16(2)31-34-17(22)3/h4-12,14H,13H2,1-3H3,(H,29,33)
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n/an/a 316n/an/an/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of cortisol-induced renilla luciferase transactiv...

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50415809
PNG
(CHEMBL1091439)
Show SMILES Cc1noc(C)c1-c1ccc(CNC(=O)c2cnc3n(Cc4ccccc4)ncc3c2Cl)cc1
Show InChI InChI=1S/C26H22ClN5O2/c1-16-23(17(2)34-31-16)20-10-8-18(9-11-20)12-29-26(33)22-13-28-25-21(24(22)27)14-30-32(25)15-19-6-4-3-5-7-19/h3-11,13-14H,12,15H2,1-2H3,(H,29,33)
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n/an/a 316n/an/an/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of cortisol-induced renilla luciferase transactiv...

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50415797
PNG
(CHEMBL1089692)
Show SMILES CCn1ncc2c(Cl)c(cnc12)C(=O)NCc1cccc(C)c1
Show InChI InChI=1S/C17H17ClN4O/c1-3-22-16-13(10-21-22)15(18)14(9-19-16)17(23)20-8-12-6-4-5-11(2)7-12/h4-7,9-10H,3,8H2,1-2H3,(H,20,23)
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n/an/a 398n/an/an/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of cortisol-induced renilla luciferase transactiv...

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50415798
PNG
(CHEMBL1089600)
Show SMILES CCn1ncc2c(Cl)c(cnc12)C(=O)NCc1ccccc1C
Show InChI InChI=1S/C17H17ClN4O/c1-3-22-16-13(10-21-22)15(18)14(9-19-16)17(23)20-8-12-7-5-4-6-11(12)2/h4-7,9-10H,3,8H2,1-2H3,(H,20,23)
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n/an/a 398n/an/an/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of cortisol-induced renilla luciferase transactiv...

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50415811
PNG
(CHEMBL1093055)
Show SMILES Cc1noc(C)c1-c1ccc(CNC(=O)c2cnc3n(ncc3c2Cl)C2CCCC2)cc1
Show InChI InChI=1S/C24H24ClN5O2/c1-14-21(15(2)32-29-14)17-9-7-16(8-10-17)11-27-24(31)20-12-26-23-19(22(20)25)13-28-30(23)18-5-3-4-6-18/h7-10,12-13,18H,3-6,11H2,1-2H3,(H,27,31)
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n/an/a 501n/an/an/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of cortisol-induced renilla luciferase transactiv...

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50415812
PNG
(CHEMBL1091066)
Show SMILES Cc1noc(C)c1-c1ccc(CNC(=O)c2cnc3n(nc(C)c3c2Cl)-c2ccccc2C)cc1
Show InChI InChI=1S/C27H24ClN5O2/c1-15-7-5-6-8-22(15)33-26-24(16(2)31-33)25(28)21(14-29-26)27(34)30-13-19-9-11-20(12-10-19)23-17(3)32-35-18(23)4/h5-12,14H,13H2,1-4H3,(H,30,34)
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n/an/a 794n/an/an/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of cortisol-induced renilla luciferase transactiv...

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50415799
PNG
(CHEMBL1093352)
Show SMILES Cn1ncc2c(Cl)c(cnc12)C(=O)NCc1ccccc1
Show InChI InChI=1S/C15H13ClN4O/c1-20-14-11(9-19-20)13(16)12(8-17-14)15(21)18-7-10-5-3-2-4-6-10/h2-6,8-9H,7H2,1H3,(H,18,21)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of cortisol-induced renilla luciferase transactiv...

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50415794
PNG
(CHEMBL1093602 | GSK-325971A)
Show SMILES CCn1ncc2c(Cl)c(cnc12)C(=O)NCc1ccc(C)cc1C
Show InChI InChI=1S/C18H19ClN4O/c1-4-23-17-14(10-22-23)16(19)15(9-20-17)18(24)21-8-13-6-5-11(2)7-12(13)3/h5-7,9-10H,4,8H2,1-3H3,(H,21,24)
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n/an/a 1.26E+3n/an/an/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at human progesterone receptor B expressed in african green monkey CV1 cells assessed as inhibition of progesterone-induced effec...

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50415790
PNG
(CHEMBL1093774 | GSK-1564023A | US10272074, Example...)
Show SMILES Cc1noc(C)c1-c1ccc(CNC(=O)c2cnc3n(C)nc(C)c3c2Cl)cc1
Show InChI InChI=1S/C21H20ClN5O2/c1-11-18-19(22)16(10-23-20(18)27(4)25-11)21(28)24-9-14-5-7-15(8-6-14)17-12(2)26-29-13(17)3/h5-8,10H,9H2,1-4H3,(H,24,28)
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n/an/a>2.51E+3n/an/an/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human PDE4B by ATP-luciferace luminescence assay

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50415790
PNG
(CHEMBL1093774 | GSK-1564023A | US10272074, Example...)
Show SMILES Cc1noc(C)c1-c1ccc(CNC(=O)c2cnc3n(C)nc(C)c3c2Cl)cc1
Show InChI InChI=1S/C21H20ClN5O2/c1-11-18-19(22)16(10-23-20(18)27(4)25-11)21(28)24-9-14-5-7-15(8-6-14)17-12(2)26-29-13(17)3/h5-8,10H,9H2,1-4H3,(H,24,28)
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n/an/a 3.16E+3n/an/an/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at human progesterone receptor B expressed in african green monkey CV1 cells assessed as inhibition of progesterone-induced effec...

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50415794
PNG
(CHEMBL1093602 | GSK-325971A)
Show SMILES CCn1ncc2c(Cl)c(cnc12)C(=O)NCc1ccc(C)cc1C
Show InChI InChI=1S/C18H19ClN4O/c1-4-23-17-14(10-22-23)16(19)15(9-20-17)18(24)21-8-13-6-5-11(2)7-12(13)3/h5-7,9-10H,4,8H2,1-3H3,(H,21,24)
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n/an/a 3.98E+3n/an/an/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human PDE4B by ATP-luciferace luminescence assay

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50415792
PNG
(CHEMBL1089743)
Show SMILES COc1cccc(c1)-c1ccccc1CNC(=O)c1cnc2n(C)nc(C)c2c1Cl
Show InChI InChI=1S/C23H21ClN4O2/c1-14-20-21(24)19(13-25-22(20)28(2)27-14)23(29)26-12-16-7-4-5-10-18(16)15-8-6-9-17(11-15)30-3/h4-11,13H,12H2,1-3H3,(H,26,29)
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n/an/a>5.01E+3n/an/an/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at human progesterone receptor B expressed in african green monkey CV1 cells assessed as inhibition of progesterone-induced effec...

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50415813
PNG
(CHEMBL1091320)
Show SMILES Cc1noc(C)c1-c1ccc(CNC(=O)c2cnc3n(nc(C)c3c2Cl)-c2ccc(C)cc2)cc1
Show InChI InChI=1S/C27H24ClN5O2/c1-15-5-11-21(12-6-15)33-26-24(16(2)31-33)25(28)22(14-29-26)27(34)30-13-19-7-9-20(10-8-19)23-17(3)32-35-18(23)4/h5-12,14H,13H2,1-4H3,(H,30,34)
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n/an/a>6.31E+3n/an/an/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of cortisol-induced renilla luciferase transactiv...

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50415805
PNG
(CHEMBL1094034)
Show SMILES COc1ccc(CNC(=O)c2cnc3n(C)nc(C)c3c2OC)cc1
Show InChI InChI=1S/C18H20N4O3/c1-11-15-16(25-4)14(10-19-17(15)22(2)21-11)18(23)20-9-12-5-7-13(24-3)8-6-12/h5-8,10H,9H2,1-4H3,(H,20,23)
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n/an/a>6.31E+3n/an/an/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of cortisol-induced renilla luciferase transactiv...

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50415804
PNG
(CHEMBL1094033)
Show SMILES CCn1nc(C)c2c(C)c(cnc12)C(=O)NCc1ccc(cc1)-c1c(C)noc1C
Show InChI InChI=1S/C23H25N5O2/c1-6-28-22-20(14(3)26-28)13(2)19(12-24-22)23(29)25-11-17-7-9-18(10-8-17)21-15(4)27-30-16(21)5/h7-10,12H,6,11H2,1-5H3,(H,25,29)
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n/an/a>6.31E+3n/an/an/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of cortisol-induced renilla luciferase transactiv...

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50415800
PNG
(CHEMBL1093353)
Show SMILES Cc1nn(C)c2ncc(C(=O)NN3CCCC3c3cccc(C)c3)c(Cl)c12
Show InChI InChI=1S/C20H22ClN5O/c1-12-6-4-7-14(10-12)16-8-5-9-26(16)24-20(27)15-11-22-19-17(18(15)21)13(2)23-25(19)3/h4,6-7,10-11,16H,5,8-9H2,1-3H3,(H,24,27)
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n/an/a>6.31E+3n/an/an/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of cortisol-induced renilla luciferase transactiv...

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50415814
PNG
(CHEMBL1094032)
Show SMILES CCn1ncc2c(Cl)c(cnc12)C(=O)NC
Show InChI InChI=1S/C10H11ClN4O/c1-3-15-9-6(5-14-15)8(11)7(4-13-9)10(16)12-2/h4-5H,3H2,1-2H3,(H,12,16)
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n/an/a>6.31E+3n/an/an/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of cortisol-induced renilla luciferase transactiv...

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50415803
PNG
(CHEMBL1094031)
Show SMILES CCCNC(=O)c1cnc2n(CC)ncc2c1Cl
Show InChI InChI=1S/C12H15ClN4O/c1-3-5-14-12(18)9-6-15-11-8(10(9)13)7-16-17(11)4-2/h6-7H,3-5H2,1-2H3,(H,14,18)
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n/an/a>6.31E+3n/an/an/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of cortisol-induced renilla luciferase transactiv...

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50415801
PNG
(CHEMBL1093354)
Show SMILES CCn1ncc2c(Cl)c(cnc12)C(=O)NCc1cncs1
Show InChI InChI=1S/C13H12ClN5OS/c1-2-19-12-9(6-18-19)11(14)10(5-16-12)13(20)17-4-8-3-15-7-21-8/h3,5-7H,2,4H2,1H3,(H,17,20)
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n/an/a>6.31E+3n/an/an/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of cortisol-induced renilla luciferase transactiv...

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50415802
PNG
(CHEMBL1089707)
Show SMILES Cc1nn(C)c2ncc(C(=O)NCc3ccccn3)c(Cl)c12
Show InChI InChI=1S/C15H14ClN5O/c1-9-12-13(16)11(8-18-14(12)21(2)20-9)15(22)19-7-10-5-3-4-6-17-10/h3-6,8H,7H2,1-2H3,(H,19,22)
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n/an/a>6.31E+3n/an/an/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of cortisol-induced renilla luciferase transactiv...

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50415796
PNG
(CHEMBL1089350)
Show SMILES CCc1nn(C)c2ncc(C(=O)NCC3Cc4ccccc4C3)c(Cl)c12
Show InChI InChI=1S/C20H21ClN4O/c1-3-16-17-18(21)15(11-22-19(17)25(2)24-16)20(26)23-10-12-8-13-6-4-5-7-14(13)9-12/h4-7,11-12H,3,8-10H2,1-2H3,(H,23,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at human progesterone receptor B expressed in african green monkey CV1 cells assessed as inhibition of progesterone-induced effec...

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Mineralocorticoid receptor


(Homo sapiens (Human))		BDBM50415792
PNG
(CHEMBL1089743)
Show SMILES COc1cccc(c1)-c1ccccc1CNC(=O)c1cnc2n(C)nc(C)c2c1Cl
Show InChI InChI=1S/C23H21ClN4O2/c1-14-20-21(24)19(13-25-22(20)28(2)27-14)23(29)26-12-16-7-4-5-10-18(16)15-8-6-9-17(11-15)30-3/h4-11,13H,12H2,1-3H3,(H,26,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at human mineralocorticoid receptor expressed in african green monkey CV1 cells assessed as inhibition of aldosterone-induced eff...

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Mineralocorticoid receptor


(Homo sapiens (Human))		BDBM50415796
PNG
(CHEMBL1089350)
Show SMILES CCc1nn(C)c2ncc(C(=O)NCC3Cc4ccccc4C3)c(Cl)c12
Show InChI InChI=1S/C20H21ClN4O/c1-3-16-17-18(21)15(11-22-19(17)25(2)24-16)20(26)23-10-12-8-13-6-4-5-7-14(13)9-12/h4-7,11-12H,3,8-10H2,1-2H3,(H,23,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at human mineralocorticoid receptor expressed in african green monkey CV1 cells assessed as inhibition of aldosterone-induced eff...

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50415796
PNG
(CHEMBL1089350)
Show SMILES CCc1nn(C)c2ncc(C(=O)NCC3Cc4ccccc4C3)c(Cl)c12
Show InChI InChI=1S/C20H21ClN4O/c1-3-16-17-18(21)15(11-22-19(17)25(2)24-16)20(26)23-10-12-8-13-6-4-5-7-14(13)9-12/h4-7,11-12H,3,8-10H2,1-2H3,(H,23,26)
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n/an/a 1.26E+4n/an/an/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human PDE4B by ATP-luciferace luminescence assay

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50415792
PNG
(CHEMBL1089743)
Show SMILES COc1cccc(c1)-c1ccccc1CNC(=O)c1cnc2n(C)nc(C)c2c1Cl
Show InChI InChI=1S/C23H21ClN4O2/c1-14-20-21(24)19(13-25-22(20)28(2)27-14)23(29)26-12-16-7-4-5-10-18(16)15-8-6-9-17(11-15)30-3/h4-11,13H,12H2,1-3H3,(H,26,29)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human PDE4B by ATP-luciferace luminescence assay

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Mineralocorticoid receptor


(Homo sapiens (Human))		BDBM50415794
PNG
(CHEMBL1093602 | GSK-325971A)
Show SMILES CCn1ncc2c(Cl)c(cnc12)C(=O)NCc1ccc(C)cc1C
Show InChI InChI=1S/C18H19ClN4O/c1-4-23-17-14(10-22-23)16(19)15(9-20-17)18(24)21-8-13-6-5-11(2)7-12(13)3/h5-7,9-10H,4,8H2,1-3H3,(H,21,24)
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n/an/a>2.00E+4n/an/an/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at human mineralocorticoid receptor expressed in african green monkey CV1 cells assessed as inhibition of aldosterone-induced eff...

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Mineralocorticoid receptor


(Homo sapiens (Human))		BDBM50415790
PNG
(CHEMBL1093774 | GSK-1564023A | US10272074, Example...)
Show SMILES Cc1noc(C)c1-c1ccc(CNC(=O)c2cnc3n(C)nc(C)c3c2Cl)cc1
Show InChI InChI=1S/C21H20ClN5O2/c1-11-18-19(22)16(10-23-20(18)27(4)25-11)21(28)24-9-14-5-7-15(8-6-14)17-12(2)26-29-13(17)3/h5-8,10H,9H2,1-4H3,(H,24,28)
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n/an/a>2.00E+4n/an/an/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at human mineralocorticoid receptor expressed in african green monkey CV1 cells assessed as inhibition of aldosterone-induced eff...

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50415796
PNG
(CHEMBL1089350)
Show SMILES CCc1nn(C)c2ncc(C(=O)NCC3Cc4ccccc4C3)c(Cl)c12
Show InChI InChI=1S/C20H21ClN4O/c1-3-16-17-18(21)15(11-22-19(17)25(2)24-16)20(26)23-10-12-8-13-6-4-5-7-14(13)9-12/h4-7,11-12H,3,8-10H2,1-2H3,(H,23,26)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at human progesterone receptor B expressed in african green monkey CV1 cells

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50415790
PNG
(CHEMBL1093774 | GSK-1564023A | US10272074, Example...)
Show SMILES Cc1noc(C)c1-c1ccc(CNC(=O)c2cnc3n(C)nc(C)c3c2Cl)cc1
Show InChI InChI=1S/C21H20ClN5O2/c1-11-18-19(22)16(10-23-20(18)27(4)25-11)21(28)24-9-14-5-7-15(8-6-14)17-12(2)26-29-13(17)3/h5-8,10H,9H2,1-4H3,(H,24,28)
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n/an/an/an/a>6.31E+3n/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as renilla luciferase transactivation activity

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50415790
PNG
(CHEMBL1093774 | GSK-1564023A | US10272074, Example...)
Show SMILES Cc1noc(C)c1-c1ccc(CNC(=O)c2cnc3n(C)nc(C)c3c2Cl)cc1
Show InChI InChI=1S/C21H20ClN5O2/c1-11-18-19(22)16(10-23-20(18)27(4)25-11)21(28)24-9-14-5-7-15(8-6-14)17-12(2)26-29-13(17)3/h5-8,10H,9H2,1-4H3,(H,24,28)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at human progesterone receptor B expressed in african green monkey CV1 cells

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50415794
PNG
(CHEMBL1093602 | GSK-325971A)
Show SMILES CCn1ncc2c(Cl)c(cnc12)C(=O)NCc1ccc(C)cc1C
Show InChI InChI=1S/C18H19ClN4O/c1-4-23-17-14(10-22-23)16(19)15(9-20-17)18(24)21-8-13-6-5-11(2)7-12(13)3/h5-7,9-10H,4,8H2,1-3H3,(H,21,24)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at human progesterone receptor B expressed in african green monkey CV1 cells

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50415796
PNG
(CHEMBL1089350)
Show SMILES CCc1nn(C)c2ncc(C(=O)NCC3Cc4ccccc4C3)c(Cl)c12
Show InChI InChI=1S/C20H21ClN4O/c1-3-16-17-18(21)15(11-22-19(17)25(2)24-16)20(26)23-10-12-8-13-6-4-5-7-14(13)9-12/h4-7,11-12H,3,8-10H2,1-2H3,(H,23,26)
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n/an/an/an/a>6.31E+3n/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as renilla luciferase transactivation activity

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Mineralocorticoid receptor


(Homo sapiens (Human))		BDBM50415792
PNG
(CHEMBL1089743)
Show SMILES COc1cccc(c1)-c1ccccc1CNC(=O)c1cnc2n(C)nc(C)c2c1Cl
Show InChI InChI=1S/C23H21ClN4O2/c1-14-20-21(24)19(13-25-22(20)28(2)27-14)23(29)26-12-16-7-4-5-10-18(16)15-8-6-9-17(11-15)30-3/h4-11,13H,12H2,1-3H3,(H,26,29)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at human mineralocorticoid receptor expressed in african green monkey CV1 cells

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Mineralocorticoid receptor


(Homo sapiens (Human))		BDBM50415794
PNG
(CHEMBL1093602 | GSK-325971A)
Show SMILES CCn1ncc2c(Cl)c(cnc12)C(=O)NCc1ccc(C)cc1C
Show InChI InChI=1S/C18H19ClN4O/c1-4-23-17-14(10-22-23)16(19)15(9-20-17)18(24)21-8-13-6-5-11(2)7-12(13)3/h5-7,9-10H,4,8H2,1-3H3,(H,21,24)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at human mineralocorticoid receptor expressed in african green monkey CV1 cells

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50415792
PNG
(CHEMBL1089743)
Show SMILES COc1cccc(c1)-c1ccccc1CNC(=O)c1cnc2n(C)nc(C)c2c1Cl
Show InChI InChI=1S/C23H21ClN4O2/c1-14-20-21(24)19(13-25-22(20)28(2)27-14)23(29)26-12-16-7-4-5-10-18(16)15-8-6-9-17(11-15)30-3/h4-11,13H,12H2,1-3H3,(H,26,29)
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n/an/an/an/a>2.00E+4n/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at human progesterone receptor B expressed in african green monkey CV1 cells

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50415792
PNG
(CHEMBL1089743)
Show SMILES COc1cccc(c1)-c1ccccc1CNC(=O)c1cnc2n(C)nc(C)c2c1Cl
Show InChI InChI=1S/C23H21ClN4O2/c1-14-20-21(24)19(13-25-22(20)28(2)27-14)23(29)26-12-16-7-4-5-10-18(16)15-8-6-9-17(11-15)30-3/h4-11,13H,12H2,1-3H3,(H,26,29)
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n/an/an/an/a>6.31E+3n/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as renilla luciferase transactivation activity

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Mineralocorticoid receptor


(Homo sapiens (Human))		BDBM50415790
PNG
(CHEMBL1093774 | GSK-1564023A | US10272074, Example...)
Show SMILES Cc1noc(C)c1-c1ccc(CNC(=O)c2cnc3n(C)nc(C)c3c2Cl)cc1
Show InChI InChI=1S/C21H20ClN5O2/c1-11-18-19(22)16(10-23-20(18)27(4)25-11)21(28)24-9-14-5-7-15(8-6-14)17-12(2)26-29-13(17)3/h5-8,10H,9H2,1-4H3,(H,24,28)
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n/an/an/an/a>2.00E+4n/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at human mineralocorticoid receptor expressed in african green monkey CV1 cells

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50415794
PNG
(CHEMBL1093602 | GSK-325971A)
Show SMILES CCn1ncc2c(Cl)c(cnc12)C(=O)NCc1ccc(C)cc1C
Show InChI InChI=1S/C18H19ClN4O/c1-4-23-17-14(10-22-23)16(19)15(9-20-17)18(24)21-8-13-6-5-11(2)7-12(13)3/h5-7,9-10H,4,8H2,1-3H3,(H,21,24)
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n/an/an/an/a>6.31E+3n/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as renilla luciferase transactivation activity

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
Mineralocorticoid receptor


(Homo sapiens (Human))		BDBM50415796
PNG
(CHEMBL1089350)
Show SMILES CCc1nn(C)c2ncc(C(=O)NCC3Cc4ccccc4C3)c(Cl)c12
Show InChI InChI=1S/C20H21ClN4O/c1-3-16-17-18(21)15(11-22-19(17)25(2)24-16)20(26)23-10-12-8-13-6-4-5-7-14(13)9-12/h4-7,11-12H,3,8-10H2,1-2H3,(H,23,26)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Medicines Research Centre

Curated by ChEMBL


Assay Description
Antagonist activity at human mineralocorticoid receptor expressed in african green monkey CV1 cells

Bioorg Med Chem Lett 20: 2340-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.133
BindingDB Entry DOI: 10.7270/Q2SF2XDJ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%