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PubMed code 20222760

Compile data set for download or QSAR
Found 61 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM233094
PNG
(N-{4-[7-(2-Diethylaminoethoxy)-6-methoxy-quinazoli...)
Show SMILES CCN(CC)CCOc1cc2ncnc(Nc3ccc(NC(C)=O)cc3)c2cc1OC
Show InChI InChI=1S/C23H29N5O3/c1-5-28(6-2)11-12-31-22-14-20-19(13-21(22)30-4)23(25-15-24-20)27-18-9-7-17(8-10-18)26-16(3)29/h7-10,13-15H,5-6,11-12H2,1-4H3,(H,26,29)(H,24,25,27)
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n/an/a 1.30E+3n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM233106
PNG
(N-{4-[6-(2-Diethylaminoethoxy)-7-methoxy-quinazoli...)
Show SMILES CCN(CC)CCOc1cc2c(Nc3ccc(NC(=O)Nc4ccc(F)cc4F)cc3)ncnc2cc1OC
Show InChI InChI=1S/C28H30F2N6O3/c1-4-36(5-2)12-13-39-26-15-21-24(16-25(26)38-3)31-17-32-27(21)33-19-7-9-20(10-8-19)34-28(37)35-23-11-6-18(29)14-22(23)30/h6-11,14-17H,4-5,12-13H2,1-3H3,(H,31,32,33)(H2,34,35,37)
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n/an/a 1.70E+3n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM233096
PNG
(Methyl {4-[7-(2-diethylaminoethoxy)-6-methoxy-quin...)
Show SMILES CCN(CC)CCOc1cc2ncnc(Nc3ccc(NC(=O)OC)cc3)c2cc1OC
Show InChI InChI=1S/C23H29N5O4/c1-5-28(6-2)11-12-32-21-14-19-18(13-20(21)30-3)22(25-15-24-19)26-16-7-9-17(10-8-16)27-23(29)31-4/h7-10,13-15H,5-6,11-12H2,1-4H3,(H,27,29)(H,24,25,26)
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n/an/a 1.70E+3n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM233112
PNG
(N-Cyclohexyl-N'-{4-[7-(2-diethylaminoethoxy)-6...)
Show SMILES CCN(CC)CCOc1cc2ncnc(Nc3ccc(NC(=O)NC4CCCCC4)cc3)c2cc1OC
Show InChI InChI=1S/C28H38N6O3/c1-4-34(5-2)15-16-37-26-18-24-23(17-25(26)36-3)27(30-19-29-24)31-21-11-13-22(14-12-21)33-28(35)32-20-9-7-6-8-10-20/h11-14,17-20H,4-10,15-16H2,1-3H3,(H,29,30,31)(H2,32,33,35)
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n/an/a 1.90E+3n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM233105
PNG
(N-{4-[6,7-Dimethoxy-quinazolin-4-ylamino]phenyl}-N...)
Show SMILES COc1cc2ncnc(Nc3ccc(NC(=O)Nc4ccc(F)cc4F)cc3)c2cc1OC
Show InChI InChI=1S/C23H19F2N5O3/c1-32-20-10-16-19(11-21(20)33-2)26-12-27-22(16)28-14-4-6-15(7-5-14)29-23(31)30-18-8-3-13(24)9-17(18)25/h3-12H,1-2H3,(H,26,27,28)(H2,29,30,31)
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n/an/a 2.10E+3n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM233095
PNG
(N-{4-[6-(2-Diethylaminoethoxy)-7-methoxy-quinazoli...)
Show SMILES CCN(CC)CCOc1cc2c(Nc3ccc(NC(C)=O)cc3)ncnc2cc1OC
Show InChI InChI=1S/C23H29N5O3/c1-5-28(6-2)11-12-31-22-13-19-20(14-21(22)30-4)24-15-25-23(19)27-18-9-7-17(8-10-18)26-16(3)29/h7-10,13-15H,5-6,11-12H2,1-4H3,(H,26,29)(H,24,25,27)
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n/an/a 2.30E+3n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM233110
PNG
(N-{4-[6-(2-Diethylaminoethoxy)-7-methoxy-quinazoli...)
Show SMILES CCCCNC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OCCN(CC)CC)cc23)cc1
Show InChI InChI=1S/C26H36N6O3/c1-5-8-13-27-26(33)31-20-11-9-19(10-12-20)30-25-21-16-24(35-15-14-32(6-2)7-3)23(34-4)17-22(21)28-18-29-25/h9-12,16-18H,5-8,13-15H2,1-4H3,(H2,27,31,33)(H,28,29,30)
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n/an/a 3.40E+3n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM233101
PNG
(N-{4-[6-(2-Diethylaminoethoxy)-7-methoxy-quinazoli...)
Show SMILES CCN(CC)CCOc1cc2c(Nc3ccc(NC(=O)Nc4ccccc4)cc3)ncnc2cc1OC
Show InChI InChI=1S/C28H32N6O3/c1-4-34(5-2)15-16-37-26-17-23-24(18-25(26)36-3)29-19-30-27(23)31-21-11-13-22(14-12-21)33-28(35)32-20-9-7-6-8-10-20/h6-14,17-19H,4-5,15-16H2,1-3H3,(H,29,30,31)(H2,32,33,35)
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n/an/a 4.30E+3n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM233109
PNG
(N-{4-[7-(2-Diethylaminoethoxy)-6-methoxy-quinazoli...)
Show SMILES CCCCNC(=O)Nc1ccc(Nc2ncnc3cc(OCCN(CC)CC)c(OC)cc23)cc1
Show InChI InChI=1S/C26H36N6O3/c1-5-8-13-27-26(33)31-20-11-9-19(10-12-20)30-25-21-16-23(34-4)24(17-22(21)28-18-29-25)35-15-14-32(6-2)7-3/h9-12,16-18H,5-8,13-15H2,1-4H3,(H2,27,31,33)(H,28,29,30)
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n/an/a 5.20E+3n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM233114
PNG
(N-Cyclohexyl-N'-{4-[6-(2-diethylaminoethoxy)-7...)
Show SMILES CCN(CC)CCOc1cc2c(Nc3ccc(NC(=O)NC4CCCCC4)cc3)ncnc2cc1OC
Show InChI InChI=1S/C28H38N6O3/c1-4-34(5-2)15-16-37-26-17-23-24(18-25(26)36-3)29-19-30-27(23)31-21-11-13-22(14-12-21)33-28(35)32-20-9-7-6-8-10-20/h11-14,17-20H,4-10,15-16H2,1-3H3,(H,29,30,31)(H2,32,33,35)
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n/an/a 8.20E+3n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM233104
PNG
(N-{4-[7-(2-Diethylaminoethoxy)-6-methoxy-quinazoli...)
Show SMILES CCN(CC)CCOc1cc2ncnc(Nc3ccc(NC(=O)Nc4ccc(F)cc4F)cc3)c2cc1OC
Show InChI InChI=1S/C28H30F2N6O3/c1-4-36(5-2)12-13-39-26-16-24-21(15-25(26)38-3)27(32-17-31-24)33-19-7-9-20(10-8-19)34-28(37)35-23-11-6-18(29)14-22(23)30/h6-11,14-17H,4-5,12-13H2,1-3H3,(H,31,32,33)(H2,34,35,37)
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n/an/a 8.30E+3n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM233100
PNG
(N-{4-[7-(2-Diethylaminoethoxy)-6-methoxy-quinazoli...)
Show SMILES CCN(CC)CCOc1cc2ncnc(Nc3ccc(NC(=O)Nc4ccccc4)cc3)c2cc1OC
Show InChI InChI=1S/C28H32N6O3/c1-4-34(5-2)15-16-37-26-18-24-23(17-25(26)36-3)27(30-19-29-24)31-21-11-13-22(14-12-21)33-28(35)32-20-9-7-6-8-10-20/h6-14,17-19H,4-5,15-16H2,1-3H3,(H,29,30,31)(H2,32,33,35)
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n/an/a 9.10E+3n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM233098
PNG
(Ethyl {4-[7-(2-diethylaminoethoxy)-6-methoxy-quina...)
Show SMILES CCOC(=O)Nc1ccc(Nc2ncnc3cc(OCCN(CC)CC)c(OC)cc23)cc1
Show InChI InChI=1S/C24H31N5O4/c1-5-29(6-2)12-13-33-22-15-20-19(14-21(22)31-4)23(26-16-25-20)27-17-8-10-18(11-9-17)28-24(30)32-7-3/h8-11,14-16H,5-7,12-13H2,1-4H3,(H,28,30)(H,25,26,27)
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n/an/a 9.40E+3n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM5447
PNG
(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)
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n/an/a 1.08E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM233097
PNG
(Methyl {4-[6-(2-diethylaminoethoxy)-7-methoxyquina...)
Show SMILES CCN(CC)CCOc1cc2c(Nc3ccc(NC(=O)OC)cc3)ncnc2cc1OC
Show InChI InChI=1S/C23H29N5O4/c1-5-28(6-2)11-12-32-21-13-18-19(14-20(21)30-3)24-15-25-22(18)26-16-7-9-17(10-8-16)27-23(29)31-4/h7-10,13-15H,5-6,11-12H2,1-4H3,(H,27,29)(H,24,25,26)
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n/an/a 1.11E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50340921
PNG
(CHEMBL1761927 | N-(4-(6,7-dimethoxyquinazolin-4-yl...)
Show SMILES COc1cc2ncnc(Nc3ccc(NC(C)=O)cc3)c2cc1OC
Show InChI InChI=1S/C18H18N4O3/c1-11(23)21-12-4-6-13(7-5-12)22-18-14-8-16(24-2)17(25-3)9-15(14)19-10-20-18/h4-10H,1-3H3,(H,21,23)(H,19,20,22)
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n/an/a 1.47E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50340944
PNG
(1-(3-chloro-4-fluorophenyl)-3-(4-(6,7-dimethoxyqui...)
Show SMILES COc1cc2ncnc(Nc3ccc(NC(=O)Nc4ccc(F)c(Cl)c4)cc3)c2cc1OC
Show InChI InChI=1S/C23H19ClFN5O3/c1-32-20-10-16-19(11-21(20)33-2)26-12-27-22(16)28-13-3-5-14(6-4-13)29-23(31)30-15-7-8-18(25)17(24)9-15/h3-12H,1-2H3,(H,26,27,28)(H2,29,30,31)
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n/an/a 1.52E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM4810
PNG
((3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-...)
Show SMILES Cc1cc(C)c(\C=C2/C(=O)Nc3ccccc23)[nH]1
Show InChI InChI=1S/C15H14N2O/c1-9-7-10(2)16-14(9)8-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)/b12-8-
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n/an/a 1.66E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM233102
PNG
(N-{4-[7-(2-Diethylaminoethoxy)-6-methoxy-quinazoli...)
Show SMILES CCN(CC)CCOc1cc2ncnc(Nc3ccc(NC(=O)Nc4ccc(OC)cc4)cc3)c2cc1OC
Show InChI InChI=1S/C29H34N6O4/c1-5-35(6-2)15-16-39-27-18-25-24(17-26(27)38-4)28(31-19-30-25)32-20-7-9-21(10-8-20)33-29(36)34-22-11-13-23(37-3)14-12-22/h7-14,17-19H,5-6,15-16H2,1-4H3,(H,30,31,32)(H2,33,34,36)
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n/an/a 1.71E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM233099
PNG
(Ethyl {4-[7-(2-diethylaminoethoxy)-6-methoxyquinaz...)
Show SMILES CCOC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OCCN(CC)CC)cc23)cc1
Show InChI InChI=1S/C24H31N5O4/c1-5-29(6-2)12-13-33-22-14-19-20(15-21(22)31-4)25-16-26-23(19)27-17-8-10-18(11-9-17)28-24(30)32-7-3/h8-11,14-16H,5-7,12-13H2,1-4H3,(H,28,30)(H,25,26,27)
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n/an/a 1.86E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM233111
PNG
(N-{4-[6-(2-Diethylaminoethoxy)-7-methoxy-quinazoli...)
Show SMILES CCNC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OCCN(CC)CC)cc23)cc1
Show InChI InChI=1S/C24H32N6O3/c1-5-25-24(31)29-18-10-8-17(9-11-18)28-23-19-14-22(33-13-12-30(6-2)7-3)21(32-4)15-20(19)26-16-27-23/h8-11,14-16H,5-7,12-13H2,1-4H3,(H2,25,29,31)(H,26,27,28)
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n/an/a 1.92E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM233106
PNG
(N-{4-[6-(2-Diethylaminoethoxy)-7-methoxy-quinazoli...)
Show SMILES CCN(CC)CCOc1cc2c(Nc3ccc(NC(=O)Nc4ccc(F)cc4F)cc3)ncnc2cc1OC
Show InChI InChI=1S/C28H30F2N6O3/c1-4-36(5-2)12-13-39-26-15-21-24(16-25(26)38-3)31-17-32-27(21)33-19-7-9-20(10-8-19)34-28(37)35-23-11-6-18(29)14-22(23)30/h6-11,14-17H,4-5,12-13H2,1-3H3,(H,31,32,33)(H2,34,35,37)
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n/an/a 2.09E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM233103
PNG
(N-{4-[6-(2-Diethylaminoethoxy)-7-methoxy-quinazoli...)
Show SMILES CCN(CC)CCOc1cc2c(Nc3ccc(NC(=O)Nc4ccc(OC)cc4)cc3)ncnc2cc1OC
Show InChI InChI=1S/C29H34N6O4/c1-5-35(6-2)15-16-39-27-17-24-25(18-26(27)38-4)30-19-31-28(24)32-20-7-9-21(10-8-20)33-29(36)34-22-11-13-23(37-3)14-12-22/h7-14,17-19H,5-6,15-16H2,1-4H3,(H,30,31,32)(H2,33,34,36)
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n/an/a 2.15E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM233105
PNG
(N-{4-[6,7-Dimethoxy-quinazolin-4-ylamino]phenyl}-N...)
Show SMILES COc1cc2ncnc(Nc3ccc(NC(=O)Nc4ccc(F)cc4F)cc3)c2cc1OC
Show InChI InChI=1S/C23H19F2N5O3/c1-32-20-10-16-19(11-21(20)33-2)26-12-27-22(16)28-14-4-6-15(7-5-14)29-23(31)30-18-8-3-13(24)9-17(18)25/h3-12H,1-2H3,(H,26,27,28)(H2,29,30,31)
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n/an/a 2.22E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM233110
PNG
(N-{4-[6-(2-Diethylaminoethoxy)-7-methoxy-quinazoli...)
Show SMILES CCCCNC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OCCN(CC)CC)cc23)cc1
Show InChI InChI=1S/C26H36N6O3/c1-5-8-13-27-26(33)31-20-11-9-19(10-12-20)30-25-21-16-24(35-15-14-32(6-2)7-3)23(34-4)17-22(21)28-18-29-25/h9-12,16-18H,5-8,13-15H2,1-4H3,(H2,27,31,33)(H,28,29,30)
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n/an/a 2.45E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM233101
PNG
(N-{4-[6-(2-Diethylaminoethoxy)-7-methoxy-quinazoli...)
Show SMILES CCN(CC)CCOc1cc2c(Nc3ccc(NC(=O)Nc4ccccc4)cc3)ncnc2cc1OC
Show InChI InChI=1S/C28H32N6O3/c1-4-34(5-2)15-16-37-26-17-23-24(18-25(26)36-3)29-19-30-27(23)31-21-11-13-22(14-12-21)33-28(35)32-20-9-7-6-8-10-20/h6-14,17-19H,4-5,15-16H2,1-3H3,(H,29,30,31)(H2,32,33,35)
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n/an/a 2.64E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM233097
PNG
(Methyl {4-[6-(2-diethylaminoethoxy)-7-methoxyquina...)
Show SMILES CCN(CC)CCOc1cc2c(Nc3ccc(NC(=O)OC)cc3)ncnc2cc1OC
Show InChI InChI=1S/C23H29N5O4/c1-5-28(6-2)11-12-32-21-13-18-19(14-20(21)30-3)24-15-25-22(18)26-16-7-9-17(10-8-16)27-23(29)31-4/h7-10,13-15H,5-6,11-12H2,1-4H3,(H,27,29)(H,24,25,26)
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n/an/a 2.67E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM233112
PNG
(N-Cyclohexyl-N'-{4-[7-(2-diethylaminoethoxy)-6...)
Show SMILES CCN(CC)CCOc1cc2ncnc(Nc3ccc(NC(=O)NC4CCCCC4)cc3)c2cc1OC
Show InChI InChI=1S/C28H38N6O3/c1-4-34(5-2)15-16-37-26-18-24-23(17-25(26)36-3)27(30-19-29-24)31-21-11-13-22(14-12-21)33-28(35)32-20-9-7-6-8-10-20/h11-14,17-20H,4-10,15-16H2,1-3H3,(H,29,30,31)(H2,32,33,35)
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n/an/a 2.82E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM233103
PNG
(N-{4-[6-(2-Diethylaminoethoxy)-7-methoxy-quinazoli...)
Show SMILES CCN(CC)CCOc1cc2c(Nc3ccc(NC(=O)Nc4ccc(OC)cc4)cc3)ncnc2cc1OC
Show InChI InChI=1S/C29H34N6O4/c1-5-35(6-2)15-16-39-27-17-24-25(18-26(27)38-4)30-19-31-28(24)32-20-7-9-21(10-8-20)33-29(36)34-22-11-13-23(37-3)14-12-22/h7-14,17-19H,5-6,15-16H2,1-4H3,(H,30,31,32)(H2,33,34,36)
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n/an/a 2.83E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50340927
PNG
(1-(4-(6,7-dimethoxyquinazolin-4-ylamino)phenyl)-3-...)
Show SMILES COc1cc2ncnc(Nc3ccc(NC(=O)Nc4ccccc4)cc3)c2cc1OC
Show InChI InChI=1S/C23H21N5O3/c1-30-20-12-18-19(13-21(20)31-2)24-14-25-22(18)26-16-8-10-17(11-9-16)28-23(29)27-15-6-4-3-5-7-15/h3-14H,1-2H3,(H,24,25,26)(H2,27,28,29)
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n/an/a 2.87E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380447
PNG
(CHEMBL2018772 | N-{4-[7-(2-Diethylaminoethoxy)-6-m...)
Show SMILES CCNC(=O)Nc1ccc(Nc2ncnc3cc(OCCN(CC)CC)c(OC)cc23)cc1
Show InChI InChI=1S/C24H32N6O3/c1-5-25-24(31)29-18-10-8-17(9-11-18)28-23-19-14-21(32-4)22(15-20(19)26-16-27-23)33-13-12-30(6-2)7-3/h8-11,14-16H,5-7,12-13H2,1-4H3,(H2,25,29,31)(H,26,27,28)
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n/an/a 2.91E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM233099
PNG
(Ethyl {4-[7-(2-diethylaminoethoxy)-6-methoxyquinaz...)
Show SMILES CCOC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OCCN(CC)CC)cc23)cc1
Show InChI InChI=1S/C24H31N5O4/c1-5-29(6-2)12-13-33-22-14-19-20(15-21(22)31-4)25-16-26-23(19)27-17-8-10-18(11-9-17)28-24(30)32-7-3/h8-11,14-16H,5-7,12-13H2,1-4H3,(H,28,30)(H,25,26,27)
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n/an/a 2.92E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM233108
PNG
(N-{4-[6-(2-Diethylaminoethoxy)-7-methoxy-quinazoli...)
Show SMILES CCN(CC)CCOc1cc2c(Nc3ccc(NC(=O)Nc4ccc(F)c(Cl)c4)cc3)ncnc2cc1OC
Show InChI InChI=1S/C28H30ClFN6O3/c1-4-36(5-2)12-13-39-26-15-21-24(16-25(26)38-3)31-17-32-27(21)33-18-6-8-19(9-7-18)34-28(37)35-20-10-11-23(30)22(29)14-20/h6-11,14-17H,4-5,12-13H2,1-3H3,(H,31,32,33)(H2,34,35,37)
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n/an/a 2.92E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM233108
PNG
(N-{4-[6-(2-Diethylaminoethoxy)-7-methoxy-quinazoli...)
Show SMILES CCN(CC)CCOc1cc2c(Nc3ccc(NC(=O)Nc4ccc(F)c(Cl)c4)cc3)ncnc2cc1OC
Show InChI InChI=1S/C28H30ClFN6O3/c1-4-36(5-2)12-13-39-26-15-21-24(16-25(26)38-3)31-17-32-27(21)33-18-6-8-19(9-7-18)34-28(37)35-20-10-11-23(30)22(29)14-20/h6-11,14-17H,4-5,12-13H2,1-3H3,(H,31,32,33)(H2,34,35,37)
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n/an/a 2.97E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM233113
PNG
(N-Cyclohexyl-N'-{4-[6,7-dimethoxy-quinazolin-4...)
Show SMILES COc1cc2ncnc(Nc3ccc(NC(=O)NC4CCCCC4)cc3)c2cc1OC
Show InChI InChI=1S/C23H27N5O3/c1-30-20-12-18-19(13-21(20)31-2)24-14-25-22(18)26-16-8-10-17(11-9-16)28-23(29)27-15-6-4-3-5-7-15/h8-15H,3-7H2,1-2H3,(H,24,25,26)(H2,27,28,29)
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n/an/a 3.04E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380468
PNG
(CHEMBL2018763 | N-{4-[6,7-Dimethoxy-quinazolin-4-y...)
Show SMILES CCCCNC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C21H25N5O3/c1-4-5-10-22-21(27)26-15-8-6-14(7-9-15)25-20-16-11-18(28-2)19(29-3)12-17(16)23-13-24-20/h6-9,11-13H,4-5,10H2,1-3H3,(H2,22,26,27)(H,23,24,25)
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n/an/a 3.06E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM233104
PNG
(N-{4-[7-(2-Diethylaminoethoxy)-6-methoxy-quinazoli...)
Show SMILES CCN(CC)CCOc1cc2ncnc(Nc3ccc(NC(=O)Nc4ccc(F)cc4F)cc3)c2cc1OC
Show InChI InChI=1S/C28H30F2N6O3/c1-4-36(5-2)12-13-39-26-16-24-21(15-25(26)38-3)27(32-17-31-24)33-19-7-9-20(10-8-19)34-28(37)35-23-11-6-18(29)14-22(23)30/h6-11,14-17H,4-5,12-13H2,1-3H3,(H,31,32,33)(H2,34,35,37)
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n/an/a 3.07E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50340921
PNG
(CHEMBL1761927 | N-(4-(6,7-dimethoxyquinazolin-4-yl...)
Show SMILES COc1cc2ncnc(Nc3ccc(NC(C)=O)cc3)c2cc1OC
Show InChI InChI=1S/C18H18N4O3/c1-11(23)21-12-4-6-13(7-5-12)22-18-14-8-16(24-2)17(25-3)9-15(14)19-10-20-18/h4-10H,1-3H3,(H,21,23)(H,19,20,22)
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n/an/a 3.13E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM233114
PNG
(N-Cyclohexyl-N'-{4-[6-(2-diethylaminoethoxy)-7...)
Show SMILES CCN(CC)CCOc1cc2c(Nc3ccc(NC(=O)NC4CCCCC4)cc3)ncnc2cc1OC
Show InChI InChI=1S/C28H38N6O3/c1-4-34(5-2)15-16-37-26-17-23-24(18-25(26)36-3)29-19-30-27(23)31-21-11-13-22(14-12-21)33-28(35)32-20-9-7-6-8-10-20/h11-14,17-20H,4-10,15-16H2,1-3H3,(H,29,30,31)(H2,32,33,35)
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n/an/a 3.23E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM233102
PNG
(N-{4-[7-(2-Diethylaminoethoxy)-6-methoxy-quinazoli...)
Show SMILES CCN(CC)CCOc1cc2ncnc(Nc3ccc(NC(=O)Nc4ccc(OC)cc4)cc3)c2cc1OC
Show InChI InChI=1S/C29H34N6O4/c1-5-35(6-2)15-16-39-27-18-25-24(17-26(27)38-4)28(31-19-30-25)32-20-7-9-21(10-8-20)33-29(36)34-22-11-13-23(37-3)14-12-22/h7-14,17-19H,5-6,15-16H2,1-4H3,(H,30,31,32)(H2,33,34,36)
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n/an/a 3.32E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM233098
PNG
(Ethyl {4-[7-(2-diethylaminoethoxy)-6-methoxy-quina...)
Show SMILES CCOC(=O)Nc1ccc(Nc2ncnc3cc(OCCN(CC)CC)c(OC)cc23)cc1
Show InChI InChI=1S/C24H31N5O4/c1-5-29(6-2)12-13-33-22-15-20-19(14-21(22)31-4)23(26-16-25-20)27-17-8-10-18(11-9-17)28-24(30)32-7-3/h8-11,14-16H,5-7,12-13H2,1-4H3,(H,28,30)(H,25,26,27)
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n/an/a 3.42E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50340930
PNG
(1-(4-(6,7-dimethoxyquinazolin-4-ylamino)phenyl)-3-...)
Show SMILES COc1ccc(NC(=O)Nc2ccc(Nc3ncnc4cc(OC)c(OC)cc34)cc2)cc1
Show InChI InChI=1S/C24H23N5O4/c1-31-18-10-8-17(9-11-18)29-24(30)28-16-6-4-15(5-7-16)27-23-19-12-21(32-2)22(33-3)13-20(19)25-14-26-23/h4-14H,1-3H3,(H,25,26,27)(H2,28,29,30)
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n/an/a 3.45E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM233107
PNG
(N-{4-[7-(2-Diethylaminoethoxy)-6-methoxy-quinazoli...)
Show SMILES CCN(CC)CCOc1cc2ncnc(Nc3ccc(NC(=O)Nc4ccc(F)c(Cl)c4)cc3)c2cc1OC
Show InChI InChI=1S/C28H30ClFN6O3/c1-4-36(5-2)12-13-39-26-16-24-21(15-25(26)38-3)27(32-17-31-24)33-18-6-8-19(9-7-18)34-28(37)35-20-10-11-23(30)22(29)14-20/h6-11,14-17H,4-5,12-13H2,1-3H3,(H,31,32,33)(H2,34,35,37)
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n/an/a 3.54E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380467
PNG
(CHEMBL2016600 | N-{4-[6,7-Dimethoxy-quinazolin-4-y...)
Show SMILES CCNC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C19H21N5O3/c1-4-20-19(25)24-13-7-5-12(6-8-13)23-18-14-9-16(26-2)17(27-3)10-15(14)21-11-22-18/h5-11H,4H2,1-3H3,(H2,20,24,25)(H,21,22,23)
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n/an/a 3.63E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380447
PNG
(CHEMBL2018772 | N-{4-[7-(2-Diethylaminoethoxy)-6-m...)
Show SMILES CCNC(=O)Nc1ccc(Nc2ncnc3cc(OCCN(CC)CC)c(OC)cc23)cc1
Show InChI InChI=1S/C24H32N6O3/c1-5-25-24(31)29-18-10-8-17(9-11-18)28-23-19-14-21(32-4)22(15-20(19)26-16-27-23)33-13-12-30(6-2)7-3/h8-11,14-16H,5-7,12-13H2,1-4H3,(H2,25,29,31)(H,26,27,28)
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n/an/a 4.03E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM233107
PNG
(N-{4-[7-(2-Diethylaminoethoxy)-6-methoxy-quinazoli...)
Show SMILES CCN(CC)CCOc1cc2ncnc(Nc3ccc(NC(=O)Nc4ccc(F)c(Cl)c4)cc3)c2cc1OC
Show InChI InChI=1S/C28H30ClFN6O3/c1-4-36(5-2)12-13-39-26-16-24-21(15-25(26)38-3)27(32-17-31-24)33-18-6-8-19(9-7-18)34-28(37)35-20-10-11-23(30)22(29)14-20/h6-11,14-17H,4-5,12-13H2,1-3H3,(H,31,32,33)(H2,34,35,37)
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n/an/a 4.32E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM233100
PNG
(N-{4-[7-(2-Diethylaminoethoxy)-6-methoxy-quinazoli...)
Show SMILES CCN(CC)CCOc1cc2ncnc(Nc3ccc(NC(=O)Nc4ccccc4)cc3)c2cc1OC
Show InChI InChI=1S/C28H32N6O3/c1-4-34(5-2)15-16-37-26-18-24-23(17-25(26)36-3)27(30-19-29-24)31-21-11-13-22(14-12-21)33-28(35)32-20-9-7-6-8-10-20/h6-14,17-19H,4-5,15-16H2,1-3H3,(H,29,30,31)(H2,32,33,35)
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n/an/a 4.41E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM233096
PNG
(Methyl {4-[7-(2-diethylaminoethoxy)-6-methoxy-quin...)
Show SMILES CCN(CC)CCOc1cc2ncnc(Nc3ccc(NC(=O)OC)cc3)c2cc1OC
Show InChI InChI=1S/C23H29N5O4/c1-5-28(6-2)11-12-32-21-14-19-18(13-20(21)30-3)22(25-15-24-19)26-16-7-9-17(10-8-16)27-23(29)31-4/h7-10,13-15H,5-6,11-12H2,1-4H3,(H,27,29)(H,24,25,26)
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n/an/a 4.52E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50340925
PNG
(CHEMBL1761931 | Ethyl {4-[6,7-dimethoxy-quinazolin...)
Show SMILES CCOC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C19H20N4O4/c1-4-27-19(24)23-13-7-5-12(6-8-13)22-18-14-9-16(25-2)17(26-3)10-15(14)20-11-21-18/h5-11H,4H2,1-3H3,(H,23,24)(H,20,21,22)
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n/an/a 4.79E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM233113
PNG
(N-Cyclohexyl-N'-{4-[6,7-dimethoxy-quinazolin-4...)
Show SMILES COc1cc2ncnc(Nc3ccc(NC(=O)NC4CCCCC4)cc3)c2cc1OC
Show InChI InChI=1S/C23H27N5O3/c1-30-20-12-18-19(13-21(20)31-2)24-14-25-22(18)26-16-8-10-17(11-9-16)28-23(29)27-15-6-4-3-5-7-15/h8-15H,3-7H2,1-2H3,(H,24,25,26)(H2,27,28,29)
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n/an/a 5.13E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM233109
PNG
(N-{4-[7-(2-Diethylaminoethoxy)-6-methoxy-quinazoli...)
Show SMILES CCCCNC(=O)Nc1ccc(Nc2ncnc3cc(OCCN(CC)CC)c(OC)cc23)cc1
Show InChI InChI=1S/C26H36N6O3/c1-5-8-13-27-26(33)31-20-11-9-19(10-12-20)30-25-21-16-23(34-4)24(17-22(21)28-18-29-25)35-15-14-32(6-2)7-3/h9-12,16-18H,5-8,13-15H2,1-4H3,(H2,27,31,33)(H,28,29,30)
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n/an/a 7.21E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50340923
PNG
(CHEMBL1761929 | Methyl {4-[6,7-dimethoxy-quinazoli...)
Show SMILES COC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C18H18N4O4/c1-24-15-8-13-14(9-16(15)25-2)19-10-20-17(13)21-11-4-6-12(7-5-11)22-18(23)26-3/h4-10H,1-3H3,(H,22,23)(H,19,20,21)
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n/an/a 7.24E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50340930
PNG
(1-(4-(6,7-dimethoxyquinazolin-4-ylamino)phenyl)-3-...)
Show SMILES COc1ccc(NC(=O)Nc2ccc(Nc3ncnc4cc(OC)c(OC)cc34)cc2)cc1
Show InChI InChI=1S/C24H23N5O4/c1-31-18-10-8-17(9-11-18)29-24(30)28-16-6-4-15(5-7-16)27-23-19-12-21(32-2)22(33-3)13-20(19)25-14-26-23/h4-14H,1-3H3,(H,25,26,27)(H2,28,29,30)
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n/an/a 7.56E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50340927
PNG
(1-(4-(6,7-dimethoxyquinazolin-4-ylamino)phenyl)-3-...)
Show SMILES COc1cc2ncnc(Nc3ccc(NC(=O)Nc4ccccc4)cc3)c2cc1OC
Show InChI InChI=1S/C23H21N5O3/c1-30-20-12-18-19(13-21(20)31-2)24-14-25-22(18)26-16-8-10-17(11-9-16)28-23(29)27-15-6-4-3-5-7-15/h3-14H,1-2H3,(H,24,25,26)(H2,27,28,29)
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n/an/a 7.78E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380467
PNG
(CHEMBL2016600 | N-{4-[6,7-Dimethoxy-quinazolin-4-y...)
Show SMILES CCNC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C19H21N5O3/c1-4-20-19(25)24-13-7-5-12(6-8-13)23-18-14-9-16(26-2)17(27-3)10-15(14)21-11-22-18/h5-11H,4H2,1-3H3,(H2,20,24,25)(H,21,22,23)
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n/an/a 7.83E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50340923
PNG
(CHEMBL1761929 | Methyl {4-[6,7-dimethoxy-quinazoli...)
Show SMILES COC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C18H18N4O4/c1-24-15-8-13-14(9-16(15)25-2)19-10-20-17(13)21-11-4-6-12(7-5-11)22-18(23)26-3/h4-10H,1-3H3,(H,22,23)(H,19,20,21)
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n/an/a 7.98E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM4810
PNG
((3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-...)
Show SMILES Cc1cc(C)c(\C=C2/C(=O)Nc3ccccc23)[nH]1
Show InChI InChI=1S/C15H14N2O/c1-9-7-10(2)16-14(9)8-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)/b12-8-
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n/an/a 8.02E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380468
PNG
(CHEMBL2018763 | N-{4-[6,7-Dimethoxy-quinazolin-4-y...)
Show SMILES CCCCNC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C21H25N5O3/c1-4-5-10-22-21(27)26-15-8-6-14(7-9-15)25-20-16-11-18(28-2)19(29-3)12-17(16)23-13-24-20/h6-9,11-13H,4-5,10H2,1-3H3,(H2,22,26,27)(H,23,24,25)
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n/an/a 8.03E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50340925
PNG
(CHEMBL1761931 | Ethyl {4-[6,7-dimethoxy-quinazolin...)
Show SMILES CCOC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C19H20N4O4/c1-4-27-19(24)23-13-7-5-12(6-8-13)22-18-14-9-16(25-2)17(26-3)10-15(14)20-11-21-18/h5-11H,4H2,1-3H3,(H,23,24)(H,20,21,22)
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n/an/a 8.12E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50340944
PNG
(1-(3-chloro-4-fluorophenyl)-3-(4-(6,7-dimethoxyqui...)
Show SMILES COc1cc2ncnc(Nc3ccc(NC(=O)Nc4ccc(F)c(Cl)c4)cc3)c2cc1OC
Show InChI InChI=1S/C23H19ClFN5O3/c1-32-20-10-16-19(11-21(20)33-2)26-12-27-22(16)28-13-3-5-14(6-4-13)29-23(31)30-15-7-8-18(25)17(24)9-15/h3-12H,1-2H3,(H,26,27,28)(H2,29,30,31)
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PubMed
n/an/a 8.19E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM5447
PNG
(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)
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PubMed
n/an/a 9.23E+4n/an/an/an/a7.5n/a



Université Lille Nord de France



Assay Description
Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...

J Enzyme Inhib Med Chem 25: 158-71 (2010)


Article DOI: 10.3109/14756360903169485
BindingDB Entry DOI: 10.7270/Q2Z31XJ2
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
* indicates data uncertainty>20%