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PubMed code 20299215

Compile data set for download or QSAR
Found 49 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315314
PNG
(8-chloro-4-(4-methylpiperazin-1-yl)benzofuro[3,2-d...)
Show SMILES CN1CCN(CC1)c1ncnc2c3cc(Cl)ccc3oc12
Show InChI InChI=1S/C15H15ClN4O/c1-19-4-6-20(7-5-19)15-14-13(17-9-18-15)11-8-10(16)2-3-12(11)21-14/h2-3,8-9H,4-7H2,1H3
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19n/an/an/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine human recombinant histamine H4 receptor


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM22914
PNG
(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Show SMILES S=C(NC1CCCCC1)N1CCC(CC1)c1cnc[nH]1
Show InChI InChI=1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20)
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27n/an/an/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine human recombinant histamine H4 receptor


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM22566
PNG
(5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)
Show SMILES CN1CCN(CC1)C(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C14H16ClN3O/c1-17-4-6-18(7-5-17)14(19)13-9-10-8-11(15)2-3-12(10)16-13/h2-3,8-9,16H,4-7H2,1H3
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38n/an/an/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine human recombinant histamine H4 receptor


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315348
PNG
((R)-8-chloro-4-(3-(methylamino)pyrrolidin-1-yl)ben...)
Show SMILES CN[C@@H]1CCN(C1)c1nc(N)nc2c3cc(Cl)ccc3oc12 |r|
Show InChI InChI=1S/C15H16ClN5O/c1-18-9-4-5-21(7-9)14-13-12(19-15(17)20-14)10-6-8(16)2-3-11(10)22-13/h2-3,6,9,18H,4-5,7H2,1H3,(H2,17,19,20)/t9-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315348
PNG
((R)-8-chloro-4-(3-(methylamino)pyrrolidin-1-yl)ben...)
Show SMILES CN[C@@H]1CCN(C1)c1nc(N)nc2c3cc(Cl)ccc3oc12 |r|
Show InChI InChI=1S/C15H16ClN5O/c1-18-9-4-5-21(7-9)14-13-12(19-15(17)20-14)10-6-8(16)2-3-11(10)22-13/h2-3,6,9,18H,4-5,7H2,1H3,(H2,17,19,20)/t9-/m1/s1
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n/an/a 3n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Inverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity ass...


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315349
PNG
((S)-8-chloro-4-(3-(methylamino)pyrrolidin-1-yl)ben...)
Show SMILES CN[C@H]1CCN(C1)c1nc(N)nc2c3cc(Cl)ccc3oc12 |r|
Show InChI InChI=1S/C15H16ClN5O/c1-18-9-4-5-21(7-9)14-13-12(19-15(17)20-14)10-6-8(16)2-3-11(10)22-13/h2-3,6,9,18H,4-5,7H2,1H3,(H2,17,19,20)/t9-/m0/s1
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n/an/a 4n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Inverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity ass...


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315349
PNG
((S)-8-chloro-4-(3-(methylamino)pyrrolidin-1-yl)ben...)
Show SMILES CN[C@H]1CCN(C1)c1nc(N)nc2c3cc(Cl)ccc3oc12 |r|
Show InChI InChI=1S/C15H16ClN5O/c1-18-9-4-5-21(7-9)14-13-12(19-15(17)20-14)10-6-8(16)2-3-11(10)22-13/h2-3,6,9,18H,4-5,7H2,1H3,(H2,17,19,20)/t9-/m0/s1
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n/an/a 13n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315314
PNG
(8-chloro-4-(4-methylpiperazin-1-yl)benzofuro[3,2-d...)
Show SMILES CN1CCN(CC1)c1ncnc2c3cc(Cl)ccc3oc12
Show InChI InChI=1S/C15H15ClN4O/c1-19-4-6-20(7-5-19)15-14-13(17-9-18-15)11-8-10(16)2-3-12(11)21-14/h2-3,8-9H,4-7H2,1H3
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n/an/a 19n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315333
PNG
((R)-N-methyl-1-(8-(trifluoromethyl)benzofuro[3,2-d...)
Show SMILES CN[C@@H]1CCN(C1)c1ncnc2c3cc(ccc3oc12)C(F)(F)F |r|
Show InChI InChI=1S/C16H15F3N4O/c1-20-10-4-5-23(7-10)15-14-13(21-8-22-15)11-6-9(16(17,18)19)2-3-12(11)24-14/h2-3,6,8,10,20H,4-5,7H2,1H3/t10-/m1/s1
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n/an/a 30n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315323
PNG
((R)-1-(8-chlorobenzofuro[3,2-d]pyrimidin-4-yl)-N-m...)
Show SMILES CN[C@@H]1CCN(C1)c1ncnc2c3cc(Cl)ccc3oc12 |r|
Show InChI InChI=1S/C15H15ClN4O/c1-17-10-4-5-20(7-10)15-14-13(18-8-19-15)11-6-9(16)2-3-12(11)21-14/h2-3,6,8,10,17H,4-5,7H2,1H3/t10-/m1/s1
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n/an/a 33n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315339
PNG
(8-chloro-2-methyl-4-(4-methylpiperazin-1-yl)benzof...)
Show SMILES CN1CCN(CC1)c1nc(C)nc2c3cc(Cl)ccc3oc12
Show InChI InChI=1S/C16H17ClN4O/c1-10-18-14-12-9-11(17)3-4-13(12)22-15(14)16(19-10)21-7-5-20(2)6-8-21/h3-4,9H,5-8H2,1-2H3
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n/an/a 37n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315342
PNG
(8-chloro-4-(4-methylpiperazin-1-yl)-2-(trifluorome...)
Show SMILES CN1CCN(CC1)c1nc(nc2c3cc(Cl)ccc3oc12)C(F)(F)F
Show InChI InChI=1S/C16H14ClF3N4O/c1-23-4-6-24(7-5-23)14-13-12(21-15(22-14)16(18,19)20)10-8-9(17)2-3-11(10)25-13/h2-3,8H,4-7H2,1H3
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n/an/a 39n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Inverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity ass...


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315323
PNG
((R)-1-(8-chlorobenzofuro[3,2-d]pyrimidin-4-yl)-N-m...)
Show SMILES CN[C@@H]1CCN(C1)c1ncnc2c3cc(Cl)ccc3oc12 |r|
Show InChI InChI=1S/C15H15ClN4O/c1-17-10-4-5-20(7-10)15-14-13(18-8-19-15)11-6-9(16)2-3-12(11)21-14/h2-3,6,8,10,17H,4-5,7H2,1H3/t10-/m1/s1
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n/an/a 41n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Inverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity ass...


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315317
PNG
(8-chloro-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2....)
Show SMILES CN1C[C@@H]2C[C@H]1CN2c1ncnc2c1oc1ccc(Cl)cc21 |r|
Show InChI InChI=1S/C16H15ClN4O/c1-20-6-11-5-10(20)7-21(11)16-15-14(18-8-19-16)12-4-9(17)2-3-13(12)22-15/h2-4,8,10-11H,5-7H2,1H3/t10-,11-/m0/s1
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n/an/a 70n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Inverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity ass...


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315331
PNG
(1-(8-chlorobenzofuro[3,2-d]pyrimidin-4-yl)-N-methy...)
Show SMILES CNC1CN(C1)c1ncnc2c3cc(Cl)ccc3oc12
Show InChI InChI=1S/C14H13ClN4O/c1-16-9-5-19(6-9)14-13-12(17-7-18-14)10-4-8(15)2-3-11(10)20-13/h2-4,7,9,16H,5-6H2,1H3
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n/an/a 76n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Inverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity ass...


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315342
PNG
(8-chloro-4-(4-methylpiperazin-1-yl)-2-(trifluorome...)
Show SMILES CN1CCN(CC1)c1nc(nc2c3cc(Cl)ccc3oc12)C(F)(F)F
Show InChI InChI=1S/C16H14ClF3N4O/c1-23-4-6-24(7-5-23)14-13-12(21-15(22-14)16(18,19)20)10-8-9(17)2-3-11(10)25-13/h2-3,8H,4-7H2,1H3
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n/an/a 83n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315332
PNG
((R)-N-methyl-1-(8-methylbenzofuro[3,2-d]pyrimidin-...)
Show SMILES CN[C@@H]1CCN(C1)c1ncnc2c1oc1ccc(C)cc21 |r|
Show InChI InChI=1S/C16H18N4O/c1-10-3-4-13-12(7-10)14-15(21-13)16(19-9-18-14)20-6-5-11(8-20)17-2/h3-4,7,9,11,17H,5-6,8H2,1-2H3/t11-/m1/s1
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n/an/a 86n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315331
PNG
(1-(8-chlorobenzofuro[3,2-d]pyrimidin-4-yl)-N-methy...)
Show SMILES CNC1CN(C1)c1ncnc2c3cc(Cl)ccc3oc12
Show InChI InChI=1S/C14H13ClN4O/c1-16-9-5-19(6-9)14-13-12(17-7-18-14)10-4-8(15)2-3-11(10)20-13/h2-4,7,9,16H,5-6H2,1H3
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n/an/a 87n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315347
PNG
(8-chloro-2-methoxy-4-(4-methylpiperazin-1-yl)benzo...)
Show SMILES COc1nc(N2CCN(C)CC2)c2oc3ccc(Cl)cc3c2n1
Show InChI InChI=1S/C16H17ClN4O2/c1-20-5-7-21(8-6-20)15-14-13(18-16(19-15)22-2)11-9-10(17)3-4-12(11)23-14/h3-4,9H,5-8H2,1-2H3
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n/an/a 90n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315322
PNG
(1-(8-chlorobenzofuro[3,2-d]pyrimidin-4-yl)-N-methy...)
Show SMILES CNC1CCN(C1)c1ncnc2c3cc(Cl)ccc3oc12
Show InChI InChI=1S/C15H15ClN4O/c1-17-10-4-5-20(7-10)15-14-13(18-8-19-15)11-6-9(16)2-3-12(11)21-14/h2-3,6,8,10,17H,4-5,7H2,1H3
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n/an/a 95n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315317
PNG
(8-chloro-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2....)
Show SMILES CN1C[C@@H]2C[C@H]1CN2c1ncnc2c1oc1ccc(Cl)cc21 |r|
Show InChI InChI=1S/C16H15ClN4O/c1-20-6-11-5-10(20)7-21(11)16-15-14(18-8-19-16)12-4-9(17)2-3-13(12)22-15/h2-4,8,10-11H,5-7H2,1H3/t10-,11-/m0/s1
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n/an/a 111n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315325
PNG
(1-(8-chlorobenzofuro[3,2-d]pyrimidin-4-yl)pyrrolid...)
Show SMILES NC1CCN(C1)c1ncnc2c1oc1ccc(Cl)cc21
Show InChI InChI=1S/C14H13ClN4O/c15-8-1-2-11-10(5-8)12-13(20-11)14(18-7-17-12)19-4-3-9(16)6-19/h1-2,5,7,9H,3-4,6,16H2
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n/an/a 126n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315318
PNG
(8-chloro-4-(5-methyl-2,5-diazabicyclo[2.2.2]octan-...)
Show SMILES CN1CC2CCC1CN2c1ncnc2c1oc1ccc(Cl)cc21
Show InChI InChI=1S/C17H17ClN4O/c1-21-7-12-4-3-11(21)8-22(12)17-16-15(19-9-20-17)13-6-10(18)2-5-14(13)23-16/h2,5-6,9,11-12H,3-4,7-8H2,1H3
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n/an/a 169n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315338
PNG
((R)-1-(7-chlorobenzofuro[3,2-d]pyrimidin-4-yl)-N-m...)
Show SMILES CN[C@@H]1CCN(C1)c1ncnc2c3ccc(Cl)cc3oc12 |r|
Show InChI InChI=1S/C15H15ClN4O/c1-17-10-4-5-20(7-10)15-14-13(18-8-19-15)11-3-2-9(16)6-12(11)21-14/h2-3,6,8,10,17H,4-5,7H2,1H3/t10-/m1/s1
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n/an/a 171n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315320
PNG
(8-chloro-4-(hexahydropyrrolo[1,2-a]pyrazin-2(1H)-y...)
Show SMILES Clc1ccc2oc3c(ncnc3c2c1)N1CCN2CCCC2C1
Show InChI InChI=1S/C17H17ClN4O/c18-11-3-4-14-13(8-11)15-16(23-14)17(20-10-19-15)22-7-6-21-5-1-2-12(21)9-22/h3-4,8,10,12H,1-2,5-7,9H2
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n/an/a 236n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315324
PNG
((S)-1-(8-chlorobenzofuro[3,2-d]pyrimidin-4-yl)-N-m...)
Show SMILES CN[C@H]1CCN(C1)c1ncnc2c3cc(Cl)ccc3oc12 |r|
Show InChI InChI=1S/C15H15ClN4O/c1-17-10-4-5-20(7-10)15-14-13(18-8-19-15)11-6-9(16)2-3-12(11)21-14/h2-3,6,8,10,17H,4-5,7H2,1H3/t10-/m0/s1
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n/an/a 285n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315324
PNG
((S)-1-(8-chlorobenzofuro[3,2-d]pyrimidin-4-yl)-N-m...)
Show SMILES CN[C@H]1CCN(C1)c1ncnc2c3cc(Cl)ccc3oc12 |r|
Show InChI InChI=1S/C15H15ClN4O/c1-17-10-4-5-20(7-10)15-14-13(18-8-19-15)11-6-9(16)2-3-12(11)21-14/h2-3,6,8,10,17H,4-5,7H2,1H3/t10-/m0/s1
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n/an/a 292n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Inverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity ass...


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315344
PNG
(8-chloro-2-cyclopropyl-4-(4-methylpiperazin-1-yl)b...)
Show SMILES CN1CCN(CC1)c1nc(nc2c3cc(Cl)ccc3oc12)C1CC1
Show InChI InChI=1S/C18H19ClN4O/c1-22-6-8-23(9-7-22)18-16-15(20-17(21-18)11-2-3-11)13-10-12(19)4-5-14(13)24-16/h4-5,10-11H,2-3,6-9H2,1H3
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n/an/a 310n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315319
PNG
(8-chloro-4-(8-methyl-3,8-diazabicyclo[3.2.1]octan-...)
Show SMILES CN1C2CCC1CN(C2)c1ncnc2c3cc(Cl)ccc3oc12
Show InChI InChI=1S/C17H17ClN4O/c1-21-11-3-4-12(21)8-22(7-11)17-16-15(19-9-20-17)13-6-10(18)2-5-14(13)23-16/h2,5-6,9,11-12H,3-4,7-8H2,1H3
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n/an/a 440n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315346
PNG
(8-chloro-4-(4-methylpiperazin-1-yl)benzofuro[3,2-d...)
Show SMILES CN1CCN(CC1)c1[nH]c(=O)nc2c3cc(Cl)ccc3oc12
Show InChI InChI=1S/C15H15ClN4O2/c1-19-4-6-20(7-5-19)14-13-12(17-15(21)18-14)10-8-9(16)2-3-11(10)22-13/h2-3,8H,4-7H2,1H3,(H,17,18,21)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315328
PNG
(8-chloro-4-(tetrahydro-1H-pyrrolo[3,4-b]pyridin-6(...)
Show SMILES Clc1ccc2oc3c(ncnc3c2c1)N1CC2CCCNC2C1
Show InChI InChI=1S/C17H17ClN4O/c18-11-3-4-14-12(6-11)15-16(23-14)17(21-9-20-15)22-7-10-2-1-5-19-13(10)8-22/h3-4,6,9-10,13,19H,1-2,5,7-8H2
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n/an/a 1.40E+3n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315327
PNG
(1-(8-chlorobenzofuro[3,2-d]pyrimidin-4-yl)-N,3-dim...)
Show SMILES CNC1(C)CCN(C1)c1ncnc2c3cc(Cl)ccc3oc12
Show InChI InChI=1S/C16H17ClN4O/c1-16(18-2)5-6-21(8-16)15-14-13(19-9-20-15)11-7-10(17)3-4-12(11)22-14/h3-4,7,9,18H,5-6,8H2,1-2H3
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n/an/a 1.40E+3n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315340
PNG
(1-(8-chloro-2-methylbenzofuro[3,2-d]pyrimidin-4-yl...)
Show SMILES CNC1CCN(C1)c1nc(C)nc2c3cc(Cl)ccc3oc12
Show InChI InChI=1S/C16H17ClN4O/c1-9-19-14-12-7-10(17)3-4-13(12)22-15(14)16(20-9)21-6-5-11(8-21)18-2/h3-4,7,11,18H,5-6,8H2,1-2H3
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n/an/a 1.60E+3n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315315
PNG
(8-chloro-4-(3,4-dimethylpiperazin-1-yl)benzofuro[3...)
Show SMILES CC1CN(CCN1C)c1ncnc2c1oc1ccc(Cl)cc21
Show InChI InChI=1S/C16H17ClN4O/c1-10-8-21(6-5-20(10)2)16-15-14(18-9-19-16)12-7-11(17)3-4-13(12)22-15/h3-4,7,9-10H,5-6,8H2,1-2H3
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n/an/a 1.90E+3n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50315348
PNG
((R)-8-chloro-4-(3-(methylamino)pyrrolidin-1-yl)ben...)
Show SMILES CN[C@@H]1CCN(C1)c1nc(N)nc2c3cc(Cl)ccc3oc12 |r|
Show InChI InChI=1S/C15H16ClN5O/c1-18-9-4-5-21(7-9)14-13-12(19-15(17)20-14)10-6-8(16)2-3-11(10)22-13/h2-3,6,9,18H,4-5,7H2,1H3,(H2,17,19,20)/t9-/m1/s1
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n/an/a 5.80E+3n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Binding affinity to histamine H3 receptor


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315336
PNG
(4-(3-(methylamino)pyrrolidin-1-yl)benzofuro[3,2-d]...)
Show SMILES CNC1CCN(C1)c1ncnc2c3cc(ccc3oc12)C#N
Show InChI InChI=1S/C16H15N5O/c1-18-11-4-5-21(8-11)16-15-14(19-9-20-16)12-6-10(7-17)2-3-13(12)22-15/h2-3,6,9,11,18H,4-5,8H2,1H3
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n/an/a 6.20E+3n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315330
PNG
(1-(8-chlorobenzofuro[3,2-d]pyrimidin-4-yl)-N-methy...)
Show SMILES CNC1CCCN(C1)c1ncnc2c3cc(Cl)ccc3oc12
Show InChI InChI=1S/C16H17ClN4O/c1-18-11-3-2-6-21(8-11)16-15-14(19-9-20-16)12-7-10(17)4-5-13(12)22-15/h4-5,7,9,11,18H,2-3,6,8H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315329
PNG
(1-(8-chlorobenzofuro[3,2-d]pyrimidin-4-yl)-N-methy...)
Show SMILES CNC1CCN(CC1)c1ncnc2c3cc(Cl)ccc3oc12
Show InChI InChI=1S/C16H17ClN4O/c1-18-11-4-6-21(7-5-11)16-15-14(19-9-20-16)12-8-10(17)2-3-13(12)22-15/h2-3,8-9,11,18H,4-7H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315316
PNG
(8-chloro-4-(3,4,5-trimethylpiperazin-1-yl)benzofur...)
Show SMILES CC1CN(CC(C)N1C)c1ncnc2c1oc1ccc(Cl)cc21
Show InChI InChI=1S/C17H19ClN4O/c1-10-7-22(8-11(2)21(10)3)17-16-15(19-9-20-17)13-6-12(18)4-5-14(13)23-16/h4-6,9-11H,7-8H2,1-3H3
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n/an/a 1.00E+4n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315345
PNG
(8-chloro-4-(4-methylpiperazin-1-yl)benzofuro[3,2-d...)
Show SMILES CN1CCN(CC1)c1nc(nc2c3cc(Cl)ccc3oc12)C(O)=O
Show InChI InChI=1S/C16H15ClN4O3/c1-20-4-6-21(7-5-20)15-13-12(18-14(19-15)16(22)23)10-8-9(17)2-3-11(10)24-13/h2-3,8H,4-7H2,1H3,(H,22,23)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315334
PNG
(CHEMBL1089166 | N-methyl-1-(8-phenylbenzofuro[3,2-...)
Show SMILES CNC1CCN(C1)c1ncnc2c1oc1ccc(cc21)-c1ccccc1
Show InChI InChI=1S/C21H20N4O/c1-22-16-9-10-25(12-16)21-20-19(23-13-24-21)17-11-15(7-8-18(17)26-20)14-5-3-2-4-6-14/h2-8,11,13,16,22H,9-10,12H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315326
PNG
(1-(8-chlorobenzofuro[3,2-d]pyrimidin-4-yl)-N-ethyl...)
Show SMILES CCNC1CCN(C1)c1ncnc2c3cc(Cl)ccc3oc12
Show InChI InChI=1S/C16H17ClN4O/c1-2-18-11-5-6-21(8-11)16-15-14(19-9-20-16)12-7-10(17)3-4-13(12)22-15/h3-4,7,9,11,18H,2,5-6,8H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315343
PNG
((R)-1-(8-chloro-2-(trifluoromethyl)benzofuro[3,2-d...)
Show SMILES CN[C@@H]1CCN(C1)c1nc(nc2c3cc(Cl)ccc3oc12)C(F)(F)F |r|
Show InChI InChI=1S/C16H14ClF3N4O/c1-21-9-4-5-24(7-9)14-13-12(22-15(23-14)16(18,19)20)10-6-8(17)2-3-11(10)25-13/h2-3,6,9,21H,4-5,7H2,1H3/t9-/m1/s1
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n/an/a 1.42E+4n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315321
PNG
(1-(8-chlorobenzofuro[3,2-d]pyrimidin-4-yl)-N,N-dim...)
Show SMILES CN(C)C1CCN(C1)c1ncnc2c3cc(Cl)ccc3oc12
Show InChI InChI=1S/C16H17ClN4O/c1-20(2)11-5-6-21(8-11)16-15-14(18-9-19-16)12-7-10(17)3-4-13(12)22-15/h3-4,7,9,11H,5-6,8H2,1-2H3
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n/an/a 2.10E+4n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50315348
PNG
((R)-8-chloro-4-(3-(methylamino)pyrrolidin-1-yl)ben...)
Show SMILES CN[C@@H]1CCN(C1)c1nc(N)nc2c3cc(Cl)ccc3oc12 |r|
Show InChI InChI=1S/C15H16ClN5O/c1-18-9-4-5-21(7-9)14-13-12(19-15(17)20-14)10-6-8(16)2-3-11(10)22-13/h2-3,6,9,18H,4-5,7H2,1H3,(H2,17,19,20)/t9-/m1/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Binding affinity to histamine H2 receptor


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50315348
PNG
((R)-8-chloro-4-(3-(methylamino)pyrrolidin-1-yl)ben...)
Show SMILES CN[C@@H]1CCN(C1)c1nc(N)nc2c3cc(Cl)ccc3oc12 |r|
Show InChI InChI=1S/C15H16ClN5O/c1-18-9-4-5-21(7-9)14-13-12(19-15(17)20-14)10-6-8(16)2-3-11(10)22-13/h2-3,6,9,18H,4-5,7H2,1H3,(H2,17,19,20)/t9-/m1/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Binding affinity to histamine H1 receptor


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315341
PNG
(8-chloro-4-(4-methylpiperazin-1-yl)-2-phenylbenzof...)
Show SMILES CN1CCN(CC1)c1nc(nc2c3cc(Cl)ccc3oc12)-c1ccccc1
Show InChI InChI=1S/C21H19ClN4O/c1-25-9-11-26(12-10-25)21-19-18(16-13-15(22)7-8-17(16)27-19)23-20(24-21)14-5-3-2-4-6-14/h2-8,13H,9-12H2,1H3
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n/an/a>3.00E+4n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315337
PNG
(CHEMBL1092881 | N-methyl-4-(3-(methylamino)pyrroli...)
Show SMILES CNC1CCN(C1)c1ncnc2c3cc(ccc3oc12)C(=O)NC
Show InChI InChI=1S/C17H19N5O2/c1-18-11-5-6-22(8-11)16-15-14(20-9-21-16)12-7-10(17(23)19-2)3-4-13(12)24-15/h3-4,7,9,11,18H,5-6,8H2,1-2H3,(H,19,23)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315335
PNG
(4-(3-(methylamino)pyrrolidin-1-yl)benzofuro[3,2-d]...)
Show SMILES CNC1CCN(C1)c1ncnc2c3cc(ccc3oc12)C(O)=O
Show InChI InChI=1S/C16H16N4O3/c1-17-10-4-5-20(7-10)15-14-13(18-8-19-15)11-6-9(16(21)22)2-3-12(11)23-14/h2-3,6,8,10,17H,4-5,7H2,1H3,(H,21,22)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%