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PubMed code 20382527

Compile data set for download or QSAR
Found 26 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50317751
PNG
(2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)
Show SMILES Cc1ccccc1NC(=O)c1cccnc1Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1
Show InChI InChI=1S/C26H20FN5O2/c1-16-5-2-3-7-21(16)32-26(33)19-6-4-12-28-25(19)31-17-8-9-23(20(27)15-17)34-22-11-14-30-24-18(22)10-13-29-24/h2-15H,1H3,(H,28,31)(H,29,30)(H,32,33)
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PubMed
n/an/a 6n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human recombinant c-met N terminal domain expressed in Hi5 insect cells after 60 mins by liquid scintillation counting


Bioorg Med Chem Lett 20: 2998-3002 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.042
BindingDB Entry DOI: 10.7270/Q2PN95TM
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50317750
PNG
(2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)
Show SMILES Fc1ccc(NC(=O)c2cccnc2Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)c(F)c1
Show InChI InChI=1S/C25H16F3N5O2/c26-14-3-5-20(18(27)12-14)33-25(34)17-2-1-9-29-24(17)32-15-4-6-22(19(28)13-15)35-21-8-11-31-23-16(21)7-10-30-23/h1-13H,(H,29,32)(H,30,31)(H,33,34)
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n/an/a 7n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human recombinant c-met N terminal domain expressed in Hi5 insect cells after 60 mins by liquid scintillation counting


Bioorg Med Chem Lett 20: 2998-3002 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.042
BindingDB Entry DOI: 10.7270/Q2PN95TM
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50317749
PNG
(2-(4-(2-aminopyridin-4-yloxy)-3-fluorophenylamino)...)
Show SMILES Nc1cc(Oc2ccc(Nc3ncccc3C(=O)Nc3ccc(F)cc3F)cc2F)ccn1
Show InChI InChI=1S/C23H16F3N5O2/c24-13-3-5-19(17(25)10-13)31-23(32)16-2-1-8-29-22(16)30-14-4-6-20(18(26)11-14)33-15-7-9-28-21(27)12-15/h1-12H,(H2,27,28)(H,29,30)(H,31,32)
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Article
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n/an/a 8n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human recombinant c-met N terminal domain expressed in Hi5 insect cells after 60 mins by liquid scintillation counting


Bioorg Med Chem Lett 20: 2998-3002 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.042
BindingDB Entry DOI: 10.7270/Q2PN95TM
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50317765
PNG
(4-(4-(2-aminopyridin-4-yloxy)-3-fluorophenylamino)...)
Show SMILES CSc1ncc(C(=O)Nc2ccc(F)cc2F)c(Nc2ccc(Oc3ccnc(N)c3)c(F)c2)n1
Show InChI InChI=1S/C23H17F3N6O2S/c1-35-23-29-11-15(22(33)31-18-4-2-12(24)8-16(18)25)21(32-23)30-13-3-5-19(17(26)9-13)34-14-6-7-28-20(27)10-14/h2-11H,1H3,(H2,27,28)(H,31,33)(H,29,30,32)
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n/an/a 9n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human recombinant c-met N terminal domain expressed in Hi5 insect cells after 60 mins by liquid scintillation counting


Bioorg Med Chem Lett 20: 2998-3002 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.042
BindingDB Entry DOI: 10.7270/Q2PN95TM
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50317759
PNG
(2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)
Show SMILES Fc1ccc(NC(=O)c2cc(Br)cnc2Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)c(F)c1
Show InChI InChI=1S/C25H15BrF3N5O2/c26-13-9-17(25(35)34-20-3-1-14(27)10-18(20)28)24(32-12-13)33-15-2-4-22(19(29)11-15)36-21-6-8-31-23-16(21)5-7-30-23/h1-12H,(H,30,31)(H,32,33)(H,34,35)
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n/an/a 9n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human recombinant c-met N terminal domain expressed in Hi5 insect cells after 60 mins by liquid scintillation counting


Bioorg Med Chem Lett 20: 2998-3002 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.042
BindingDB Entry DOI: 10.7270/Q2PN95TM
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50317756
PNG
(2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)
Show SMILES OCCc1ccccc1NC(=O)c1cccnc1Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1
Show InChI InChI=1S/C27H22FN5O3/c28-21-16-18(7-8-24(21)36-23-10-14-31-25-19(23)9-13-30-25)32-26-20(5-3-12-29-26)27(35)33-22-6-2-1-4-17(22)11-15-34/h1-10,12-14,16,34H,11,15H2,(H,29,32)(H,30,31)(H,33,35)
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n/an/a 9n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human recombinant c-met N terminal domain expressed in Hi5 insect cells after 60 mins by liquid scintillation counting


Bioorg Med Chem Lett 20: 2998-3002 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.042
BindingDB Entry DOI: 10.7270/Q2PN95TM
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50317748
PNG
(2-(4-(2-aminopyridin-4-yloxy)-3-fluorophenylamino)...)
Show SMILES Nc1cc(Oc2ccc(Nc3ncccc3C(=O)Nc3ccc(Cl)cc3)cc2F)ccn1
Show InChI InChI=1S/C23H17ClFN5O2/c24-14-3-5-15(6-4-14)30-23(31)18-2-1-10-28-22(18)29-16-7-8-20(19(25)12-16)32-17-9-11-27-21(26)13-17/h1-13H,(H2,26,27)(H,28,29)(H,30,31)
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n/an/a 11n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human recombinant c-met N terminal domain expressed in Hi5 insect cells after 60 mins by liquid scintillation counting


Bioorg Med Chem Lett 20: 2998-3002 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.042
BindingDB Entry DOI: 10.7270/Q2PN95TM
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50317758
PNG
(2-(4-(2-aminopyridin-4-yloxy)-3-fluorophenylamino)...)
Show SMILES Nc1cc(Oc2ccc(Nc3ncc(Br)cc3C(=O)Nc3ccc(F)cc3F)cc2F)ccn1
Show InChI InChI=1S/C23H15BrF3N5O2/c24-12-7-16(23(33)32-19-3-1-13(25)8-17(19)26)22(30-11-12)31-14-2-4-20(18(27)9-14)34-15-5-6-29-21(28)10-15/h1-11H,(H2,28,29)(H,30,31)(H,32,33)
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n/an/a 13n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human recombinant c-met N terminal domain expressed in Hi5 insect cells after 60 mins by liquid scintillation counting


Bioorg Med Chem Lett 20: 2998-3002 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.042
BindingDB Entry DOI: 10.7270/Q2PN95TM
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50317757
PNG
(2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)
Show SMILES Cc1ccc(C(=O)Nc2ccc(F)cc2F)c(Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)n1
Show InChI InChI=1S/C26H18F3N5O2/c1-14-2-5-18(26(35)34-21-6-3-15(27)12-19(21)28)25(32-14)33-16-4-7-23(20(29)13-16)36-22-9-11-31-24-17(22)8-10-30-24/h2-13H,1H3,(H,30,31)(H,32,33)(H,34,35)
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n/an/a 18n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human recombinant c-met N terminal domain expressed in Hi5 insect cells after 60 mins by liquid scintillation counting


Bioorg Med Chem Lett 20: 2998-3002 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.042
BindingDB Entry DOI: 10.7270/Q2PN95TM
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50317755
PNG
(2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)
Show SMILES Fc1cc(Nc2ncccc2C(=O)Nc2ccccc2)ccc1Oc1ccnc2[nH]ccc12
Show InChI InChI=1S/C25H18FN5O2/c26-20-15-17(8-9-22(20)33-21-11-14-29-23-18(21)10-13-28-23)30-24-19(7-4-12-27-24)25(32)31-16-5-2-1-3-6-16/h1-15H,(H,27,30)(H,28,29)(H,31,32)
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n/an/a 21n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human recombinant c-met N terminal domain expressed in Hi5 insect cells after 60 mins by liquid scintillation counting


Bioorg Med Chem Lett 20: 2998-3002 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.042
BindingDB Entry DOI: 10.7270/Q2PN95TM
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50317764
PNG
(4-(4-(2-aminopyridin-4-yloxy)-3-fluorophenylamino)...)
Show SMILES Nc1cc(Oc2ccc(Nc3ncncc3C(=O)Nc3ccc(F)cc3F)cc2F)ccn1
Show InChI InChI=1S/C22H15F3N6O2/c23-12-1-3-18(16(24)7-12)31-22(32)15-10-27-11-29-21(15)30-13-2-4-19(17(25)8-13)33-14-5-6-28-20(26)9-14/h1-11H,(H2,26,28)(H,31,32)(H,27,29,30)
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n/an/a 22n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human recombinant c-met N terminal domain expressed in Hi5 insect cells after 60 mins by liquid scintillation counting


Bioorg Med Chem Lett 20: 2998-3002 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.042
BindingDB Entry DOI: 10.7270/Q2PN95TM
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50317752
PNG
(2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)
Show SMILES Fc1cc(Nc2ncccc2C(=O)Nc2ccccc2Cl)ccc1Oc1ccnc2[nH]ccc12
Show InChI InChI=1S/C25H17ClFN5O2/c26-18-5-1-2-6-20(18)32-25(33)17-4-3-11-28-24(17)31-15-7-8-22(19(27)14-15)34-21-10-13-30-23-16(21)9-12-29-23/h1-14H,(H,28,31)(H,29,30)(H,32,33)
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n/an/a 24n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human recombinant c-met N terminal domain expressed in Hi5 insect cells after 60 mins by liquid scintillation counting


Bioorg Med Chem Lett 20: 2998-3002 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.042
BindingDB Entry DOI: 10.7270/Q2PN95TM
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50317754
PNG
(2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)
Show SMILES Fc1ccc(NC(=O)c2cccnc2Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)nc1
Show InChI InChI=1S/C24H16F2N6O2/c25-14-3-6-21(30-13-14)32-24(33)17-2-1-9-27-23(17)31-15-4-5-20(18(26)12-15)34-19-8-11-29-22-16(19)7-10-28-22/h1-13H,(H,27,31)(H,28,29)(H,30,32,33)
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n/an/a 34n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human recombinant c-met N terminal domain expressed in Hi5 insect cells after 60 mins by liquid scintillation counting


Bioorg Med Chem Lett 20: 2998-3002 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.042
BindingDB Entry DOI: 10.7270/Q2PN95TM
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50317763
PNG
(3-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)
Show SMILES Fc1ccc(NC(=O)c2nccnc2Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)c(F)c1
Show InChI InChI=1S/C24H15F3N6O2/c25-13-1-3-18(16(26)11-13)33-24(34)21-23(31-10-9-28-21)32-14-2-4-20(17(27)12-14)35-19-6-8-30-22-15(19)5-7-29-22/h1-12H,(H,29,30)(H,31,32)(H,33,34)
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n/an/a 55n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human recombinant c-met N terminal domain expressed in Hi5 insect cells after 60 mins by liquid scintillation counting


Bioorg Med Chem Lett 20: 2998-3002 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.042
BindingDB Entry DOI: 10.7270/Q2PN95TM
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50317762
PNG
(3-(4-(2-aminopyridin-4-yloxy)-3-fluorophenylamino)...)
Show SMILES Nc1cc(Oc2ccc(Nc3nccnc3C(=O)Nc3ccc(F)cc3F)cc2F)ccn1
Show InChI InChI=1S/C22H15F3N6O2/c23-12-1-3-17(15(24)9-12)31-22(32)20-21(29-8-7-28-20)30-13-2-4-18(16(25)10-13)33-14-5-6-27-19(26)11-14/h1-11H,(H2,26,27)(H,29,30)(H,31,32)
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n/an/a 69n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human recombinant c-met N terminal domain expressed in Hi5 insect cells after 60 mins by liquid scintillation counting


Bioorg Med Chem Lett 20: 2998-3002 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.042
BindingDB Entry DOI: 10.7270/Q2PN95TM
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM50317750
PNG
(2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)
Show SMILES Fc1ccc(NC(=O)c2cccnc2Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)c(F)c1
Show InChI InChI=1S/C25H16F3N5O2/c26-14-3-5-20(18(27)12-14)33-25(34)17-2-1-9-29-24(17)32-15-4-6-22(19(28)13-15)35-21-8-11-31-23-16(21)7-10-30-23/h1-13H,(H,29,32)(H,30,31)(H,33,34)
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n/an/a 120n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of FLT3


Bioorg Med Chem Lett 20: 2998-3002 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.042
BindingDB Entry DOI: 10.7270/Q2PN95TM
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50317766
PNG
(4-(4-(2-aminopyridin-4-yloxy)-3-fluorophenylamino)...)
Show SMILES CN(C)c1ncc(C(=O)Nc2ccc(F)cc2F)c(Nc2ccc(Oc3ccnc(N)c3)c(F)c2)n1
Show InChI InChI=1S/C24H20F3N7O2/c1-34(2)24-30-12-16(23(35)32-19-5-3-13(25)9-17(19)26)22(33-24)31-14-4-6-20(18(27)10-14)36-15-7-8-29-21(28)11-15/h3-12H,1-2H3,(H2,28,29)(H,32,35)(H,30,31,33)
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n/an/a 120n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human recombinant c-met N terminal domain expressed in Hi5 insect cells after 60 mins by liquid scintillation counting


Bioorg Med Chem Lett 20: 2998-3002 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.042
BindingDB Entry DOI: 10.7270/Q2PN95TM
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50317753
PNG
(2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)
Show SMILES CN(C(=O)c1cccnc1Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1)c1ccc(F)cc1
Show InChI InChI=1S/C26H19F2N5O2/c1-33(18-7-4-16(27)5-8-18)26(34)20-3-2-12-29-25(20)32-17-6-9-23(21(28)15-17)35-22-11-14-31-24-19(22)10-13-30-24/h2-15H,1H3,(H,29,32)(H,30,31)
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n/an/a 190n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human recombinant c-met N terminal domain expressed in Hi5 insect cells after 60 mins by liquid scintillation counting


Bioorg Med Chem Lett 20: 2998-3002 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.042
BindingDB Entry DOI: 10.7270/Q2PN95TM
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50317761
PNG
(4-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)
Show SMILES Fc1ccc(NC(=O)c2cnccc2Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)c(F)c1
Show InChI InChI=1S/C25H16F3N5O2/c26-14-1-3-21(18(27)11-14)33-25(34)17-13-29-8-6-20(17)32-15-2-4-23(19(28)12-15)35-22-7-10-31-24-16(22)5-9-30-24/h1-13H,(H,29,32)(H,30,31)(H,33,34)
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n/an/a 270n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human recombinant c-met N terminal domain expressed in Hi5 insect cells after 60 mins by liquid scintillation counting


Bioorg Med Chem Lett 20: 2998-3002 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.042
BindingDB Entry DOI: 10.7270/Q2PN95TM
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM50317750
PNG
(2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)
Show SMILES Fc1ccc(NC(=O)c2cccnc2Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)c(F)c1
Show InChI InChI=1S/C25H16F3N5O2/c26-14-3-5-20(18(27)12-14)33-25(34)17-2-1-9-29-24(17)32-15-4-6-22(19(28)13-15)35-21-8-11-31-23-16(21)7-10-30-23/h1-13H,(H,29,32)(H,30,31)(H,33,34)
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n/an/a 350n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of TrkA


Bioorg Med Chem Lett 20: 2998-3002 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.042
BindingDB Entry DOI: 10.7270/Q2PN95TM
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50317760
PNG
(4-(4-(2-aminopyridin-4-yloxy)-3-fluorophenylamino)...)
Show SMILES Nc1cc(Oc2ccc(Nc3ccncc3C(=O)Nc3ccc(F)cc3F)cc2F)ccn1
Show InChI InChI=1S/C23H16F3N5O2/c24-13-1-3-20(17(25)9-13)31-23(32)16-12-28-7-6-19(16)30-14-2-4-21(18(26)10-14)33-15-5-8-29-22(27)11-15/h1-12H,(H2,27,29)(H,28,30)(H,31,32)
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n/an/a 3.50E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human recombinant c-met N terminal domain expressed in Hi5 insect cells after 60 mins by liquid scintillation counting


Bioorg Med Chem Lett 20: 2998-3002 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.042
BindingDB Entry DOI: 10.7270/Q2PN95TM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50317750
PNG
(2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)
Show SMILES Fc1ccc(NC(=O)c2cccnc2Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)c(F)c1
Show InChI InChI=1S/C25H16F3N5O2/c26-14-3-5-20(18(27)12-14)33-25(34)17-2-1-9-29-24(17)32-15-4-6-22(19(28)13-15)35-21-8-11-31-23-16(21)7-10-30-23/h1-13H,(H,29,32)(H,30,31)(H,33,34)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of LcK


Bioorg Med Chem Lett 20: 2998-3002 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.042
BindingDB Entry DOI: 10.7270/Q2PN95TM
More data for this
Ligand-Target Pair
High affinity immunoglobulin gamma Fc receptor I


(Homo sapiens (Human))
BDBM50317750
PNG
(2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)
Show SMILES Fc1ccc(NC(=O)c2cccnc2Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)c(F)c1
Show InChI InChI=1S/C25H16F3N5O2/c26-14-3-5-20(18(27)12-14)33-25(34)17-2-1-9-29-24(17)32-15-4-6-22(19(28)13-15)35-21-8-11-31-23-16(21)7-10-30-23/h1-13H,(H,29,32)(H,30,31)(H,33,34)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of IGFR1


Bioorg Med Chem Lett 20: 2998-3002 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.042
BindingDB Entry DOI: 10.7270/Q2PN95TM
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (Human))
BDBM50317750
PNG
(2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)
Show SMILES Fc1ccc(NC(=O)c2cccnc2Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)c(F)c1
Show InChI InChI=1S/C25H16F3N5O2/c26-14-3-5-20(18(27)12-14)33-25(34)17-2-1-9-29-24(17)32-15-4-6-22(19(28)13-15)35-21-8-11-31-23-16(21)7-10-30-23/h1-13H,(H,29,32)(H,30,31)(H,33,34)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of InsR


Bioorg Med Chem Lett 20: 2998-3002 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.042
BindingDB Entry DOI: 10.7270/Q2PN95TM
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50317750
PNG
(2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)
Show SMILES Fc1ccc(NC(=O)c2cccnc2Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)c(F)c1
Show InChI InChI=1S/C25H16F3N5O2/c26-14-3-5-20(18(27)12-14)33-25(34)17-2-1-9-29-24(17)32-15-4-6-22(19(28)13-15)35-21-8-11-31-23-16(21)7-10-30-23/h1-13H,(H,29,32)(H,30,31)(H,33,34)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PKCalpha


Bioorg Med Chem Lett 20: 2998-3002 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.042
BindingDB Entry DOI: 10.7270/Q2PN95TM
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (Human))
BDBM50317750
PNG
(2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)
Show SMILES Fc1ccc(NC(=O)c2cccnc2Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)c(F)c1
Show InChI InChI=1S/C25H16F3N5O2/c26-14-3-5-20(18(27)12-14)33-25(34)17-2-1-9-29-24(17)32-15-4-6-22(19(28)13-15)35-21-8-11-31-23-16(21)7-10-30-23/h1-13H,(H,29,32)(H,30,31)(H,33,34)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of MK2


Bioorg Med Chem Lett 20: 2998-3002 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.042
BindingDB Entry DOI: 10.7270/Q2PN95TM
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%