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PubMed code 20450197

Compile data set for download or QSAR
Found 80 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM31592
PNG
(PF-2545920 | US9138494, MP-10 | substituted pyraz...)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2ccc3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C25H20N4O/c1-29-16-23(18-12-14-26-15-13-18)25(28-29)20-7-10-22(11-8-20)30-17-21-9-6-19-4-2-3-5-24(19)27-21/h2-16H,17H2,1H3
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n/an/a 1.30n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319169
PNG
(3,4-Dimethoxy-1-isobutyl-8-methoxy-imidazo[1,5-a]p...)
Show SMILES COc1ccc2nc(C)c3c(C)nc(CC(C)C)n3c2n1
Show InChI InChI=1S/C16H20N4O/c1-9(2)8-13-18-11(4)15-10(3)17-12-6-7-14(21-5)19-16(12)20(13)15/h6-7,9H,8H2,1-5H3
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n/an/a 1.40n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319168
PNG
(1-Cyclohexyl-3,4-dimethyl-8-methoxy-imidazo[1,5-a]...)
Show SMILES COc1ccc2nc(C)c3c(C)nc(C4CCCCC4)n3c2n1
Show InChI InChI=1S/C18H22N4O/c1-11-16-12(2)20-17(13-7-5-4-6-8-13)22(16)18-14(19-11)9-10-15(21-18)23-3/h9-10,13H,4-8H2,1-3H3
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n/an/a 2.80n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319163
PNG
(8-Methoxy-3-methyl-4-methylsulfonylamino-1-propyl-...)
Show SMILES CCCc1nc(C)c2c(NS(C)(=O)=O)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H19N5O3S/c1-5-6-11-16-9(2)13-14(19-24(4,21)22)17-10-7-8-12(23-3)18-15(10)20(11)13/h7-8H,5-6H2,1-4H3,(H,17,19)
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n/an/a 7.20n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319165
PNG
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Show SMILES CCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3
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n/an/a 7.30n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319164
PNG
(4-Difluoromethyl-8-methoxy-3-methyl-1-propyl-imida...)
Show SMILES CCCc1nc(C)c2c(nc3ccc(OC)nc3n12)C(F)F
Show InChI InChI=1S/C15H16F2N4O/c1-4-5-10-18-8(2)13-12(14(16)17)19-9-6-7-11(22-3)20-15(9)21(10)13/h6-7,14H,4-5H2,1-3H3
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n/an/a 7.30n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319166
PNG
(1-Propyl-3,4,8-trimethyl-imidazo[1,5-a]pyrido[3,2-...)
Show SMILES CCCc1nc(C)c2c(C)nc3ccc(C)nc3n12
Show InChI InChI=1S/C15H18N4/c1-5-6-13-18-11(4)14-10(3)17-12-8-7-9(2)16-15(12)19(13)14/h7-8H,5-6H2,1-4H3
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n/an/a 8.30n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319159
PNG
(4-Cyano-1-cyclohexyl-8-methoxy-3-methyl-imidazo[1,...)
Show SMILES COc1ccc2nc(C#N)c3c(C)nc(C4CCCCC4)n3c2n1
Show InChI InChI=1S/C18H19N5O/c1-11-16-14(10-19)21-13-8-9-15(24-2)22-18(13)23(16)17(20-11)12-6-4-3-5-7-12/h8-9,12H,3-7H2,1-2H3
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n/an/a 9.60n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319157
PNG
(4-Cyano-8-methoxy-3-methyl-1-propyl-imidazo[1,5-a]...)
Show SMILES CCCc1nc(C)c2c(nc3ccc(OC)nc3n12)C#N
Show InChI InChI=1S/C15H15N5O/c1-4-5-12-17-9(2)14-11(8-16)18-10-6-7-13(21-3)19-15(10)20(12)14/h6-7H,4-5H2,1-3H3
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n/an/a 11n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319160
PNG
(4-Ethyl-8-methoxy-3-methyl-1-propyl-imidazo[1,5-a]...)
Show SMILES CCCc1nc(C)c2c(CC)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C16H20N4O/c1-5-7-13-17-10(3)15-11(6-2)18-12-8-9-14(21-4)19-16(12)20(13)15/h8-9H,5-7H2,1-4H3
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n/an/a 12n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319162
PNG
(8-Difluoromethoxy-3,4-dimethyl-1-propyl-imidazo[1,...)
Show SMILES CCCc1nc(C)c2c(C)nc3ccc(OC(F)F)nc3n12
Show InChI InChI=1S/C15H16F2N4O/c1-4-5-11-19-9(3)13-8(2)18-10-6-7-12(22-15(16)17)20-14(10)21(11)13/h6-7,15H,4-5H2,1-3H3
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n/an/a 13n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319161
PNG
(4-(N,N-bis-methylsulfonyl)-8-methoxy-3-methyl-1-pr...)
Show SMILES CCCc1nc(C)c2c(nc3ccc(OC)nc3n12)N(S(C)(=O)=O)S(C)(=O)=O
Show InChI InChI=1S/C16H21N5O5S2/c1-6-7-12-17-10(2)14-16(21(27(4,22)23)28(5,24)25)18-11-8-9-13(26-3)19-15(11)20(12)14/h8-9H,6-7H2,1-5H3
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n/an/a 15n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319167
PNG
(3,4-Dimethyl-1-ethyl-8-methoxy-imidazo[1,5-a]pyrid...)
Show SMILES CCc1nc(C)c2c(C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C14H16N4O/c1-5-11-16-9(3)13-8(2)15-10-6-7-12(19-4)17-14(10)18(11)13/h6-7H,5H2,1-4H3
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n/an/a 16n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319152
PNG
(1-Benzyl-3,4-dimethyl-8-methoxy-imidazo[1,5-a]pyri...)
Show SMILES COc1ccc2nc(C)c3c(C)nc(Cc4ccccc4)n3c2n1
Show InChI InChI=1S/C19H18N4O/c1-12-18-13(2)21-16(11-14-7-5-4-6-8-14)23(18)19-15(20-12)9-10-17(22-19)24-3/h4-10H,11H2,1-3H3
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n/an/a 21n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319155
PNG
(8-Methoxy-4-methoxycarbonylamino-3-methyl-1-propyl...)
Show SMILES CCCc1nc(C)c2c(NC(=O)OC)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C16H19N5O3/c1-5-6-11-17-9(2)13-14(20-16(22)24-4)18-10-7-8-12(23-3)19-15(10)21(11)13/h7-8H,5-6H2,1-4H3,(H,18,20,22)
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n/an/a 23n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319158
PNG
(8-Methoxy-3-methyl-4-methylsulfonyl-1-propyl-imida...)
Show SMILES CCCc1nc(C)c2c(nc3ccc(OC)nc3n12)S(C)(=O)=O
Show InChI InChI=1S/C15H18N4O3S/c1-5-6-11-16-9(2)13-15(23(4,20)21)17-10-7-8-12(22-3)18-14(10)19(11)13/h7-8H,5-6H2,1-4H3
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n/an/a 23n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319156
PNG
(8-Methoxy-4-methyl-1-propyl-imidazo[1,5-a]pyrido[3...)
Show SMILES CCCc1ncc2c(C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C14H16N4O/c1-4-5-12-15-8-11-9(2)16-10-6-7-13(19-3)17-14(10)18(11)12/h6-8H,4-5H2,1-3H3
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n/an/a 25n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319149
PNG
(4,8-Dimethoxy-3-methyl-1-propyl-imidazo[1,5-a]pyri...)
Show SMILES CCCc1nc(C)c2c(OC)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H18N4O2/c1-5-6-11-16-9(2)13-15(21-4)17-10-7-8-12(20-3)18-14(10)19(11)13/h7-8H,5-6H2,1-4H3
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n/an/a 25n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319148
PNG
(3,4-Dimethyl-1-propyl-imidazo[1,5-a]pyrido[3,2-e]p...)
Show SMILES CCCc1nc(C)c2c(C)nc3cccnc3n12
Show InChI InChI=1S/C14H16N4/c1-4-6-12-17-10(3)13-9(2)16-11-7-5-8-15-14(11)18(12)13/h5,7-8H,4,6H2,1-3H3
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n/an/a 33n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319186
PNG
(8-Methoxy-3-methyl-1-propyl-imidazo[1,5-a]pyrido[3...)
Show SMILES CCCc1nc(C)c2cnc3ccc(OC)nc3n12
Show InChI InChI=1S/C14H16N4O/c1-4-5-12-16-9(2)11-8-15-10-6-7-13(19-3)17-14(10)18(11)12/h6-8H,4-5H2,1-3H3
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Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319185
PNG
(4-Cyano-1-ethyl-8-methoxy-3-methyl-imidazo[1,5-a]p...)
Show SMILES CCc1nc(C)c2c(nc3ccc(OC)nc3n12)C#N
Show InChI InChI=1S/C14H13N5O/c1-4-11-16-8(2)13-10(7-15)17-9-5-6-12(20-3)18-14(9)19(11)13/h5-6H,4H2,1-3H3
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Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319154
PNG
(4-Ethylsulfonylamino-8-methoxy-3-methyl-1-propyl-i...)
Show SMILES CCCc1nc(C)c2c(NS(=O)(=O)CC)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C16H21N5O3S/c1-5-7-12-17-10(3)14-15(20-25(22,23)6-2)18-11-8-9-13(24-4)19-16(11)21(12)14/h8-9H,5-7H2,1-4H3,(H,18,20)
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n/an/a 39n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319153
PNG
(8-Methoxy-3-methyl-1-propyl-4-trifluoromethyl-imid...)
Show SMILES CCCc1nc(C)c2c(nc3ccc(OC)nc3n12)C(F)(F)F
Show InChI InChI=1S/C15H15F3N4O/c1-4-5-10-19-8(2)12-13(15(16,17)18)20-9-6-7-11(23-3)21-14(9)22(10)12/h6-7H,4-5H2,1-3H3
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Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319151
PNG
(3,4-Dimethyl-8-methoxy-1-pentyl-imidazo[1,5-a]pyri...)
Show SMILES CCCCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C17H22N4O/c1-5-6-7-8-14-19-12(3)16-11(2)18-13-9-10-15(22-4)20-17(13)21(14)16/h9-10H,5-8H2,1-4H3
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Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319183
PNG
(8-Methoxy-3-methyl-1-propyl-4-trifluoromethylsulfo...)
Show SMILES CCCc1nc(C)c2c(NS(=O)(=O)C(F)(F)F)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H16F3N5O3S/c1-4-5-10-19-8(2)12-13(22-27(24,25)15(16,17)18)20-9-6-7-11(26-3)21-14(9)23(10)12/h6-7H,4-5H2,1-3H3,(H,20,22)
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Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319182
PNG
(8-Methoxy-3-methyl-1-propyl-4-ureido-imidazo[1,5-a...)
Show SMILES CCCc1nc(C)c2c(NC(N)=O)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H18N6O2/c1-4-5-10-17-8(2)12-13(20-15(16)22)18-9-6-7-11(23-3)19-14(9)21(10)12/h6-7H,4-5H2,1-3H3,(H3,16,18,20,22)
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Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319147
PNG
(4,8-Dimethoxy-1-ethyl-3-methyl-imidazo[1,5-a]pyrid...)
Show SMILES CCc1nc(C)c2c(OC)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C14H16N4O2/c1-5-10-15-8(2)12-14(20-4)16-9-6-7-11(19-3)17-13(9)18(10)12/h6-7H,5H2,1-4H3
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Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319187
PNG
(1-Ethyl-8-methoxy-3-methyl-4-methylsulfonylamino-i...)
Show SMILES CCc1nc(C)c2c(NS(C)(=O)=O)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C14H17N5O3S/c1-5-10-15-8(2)12-13(18-23(4,20)21)16-9-6-7-11(22-3)17-14(9)19(10)12/h6-7H,5H2,1-4H3,(H,16,18)
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Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM50319163
PNG
(8-Methoxy-3-methyl-4-methylsulfonylamino-1-propyl-...)
Show SMILES CCCc1nc(C)c2c(NS(C)(=O)=O)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H19N5O3S/c1-5-6-11-16-9(2)13-14(19-24(4,21)22)17-10-7-8-12(23-3)18-15(10)20(11)13/h7-8H,5-6H2,1-4H3,(H,17,19)
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Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of PDE11A


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM14754
PNG
(1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoq...)
Show SMILES COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OC
Show InChI InChI=1S/C20H21NO4/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16/h5-8,10-12H,9H2,1-4H3
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Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM14754
PNG
(1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoq...)
Show SMILES COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OC
Show InChI InChI=1S/C20H21NO4/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16/h5-8,10-12H,9H2,1-4H3
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Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319146
PNG
(8-Methoxy-1,3,4-trimethyl-imidazo[1,5-a]pyrido[3,2...)
Show SMILES COc1ccc2nc(C)c3c(C)nc(C)n3c2n1
Show InChI InChI=1S/C13H14N4O/c1-7-12-8(2)15-10-5-6-11(18-4)16-13(10)17(12)9(3)14-7/h5-6H,1-4H3
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Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319181
PNG
(4-(N,N-Bis-ethoxycarbonyl-amino)-8-methoxy-3-methy...)
Show SMILES CCCc1nc(C)c2c(nc3ccc(OC)nc3n12)N(C(=O)OC)C(=O)OC
Show InChI InChI=1S/C18H21N5O5/c1-6-7-12-19-10(2)14-16(23(17(24)27-4)18(25)28-5)20-11-8-9-13(26-3)21-15(11)22(12)14/h8-9H,6-7H2,1-5H3
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Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319150
PNG
(8-Methoxy-3-methyl-4-methylsulfinyl-1-propyl-imida...)
Show SMILES CCCc1nc(C)c2c(nc3ccc(OC)nc3n12)S(C)=O
Show InChI InChI=1S/C15H18N4O2S/c1-5-6-11-16-9(2)13-15(22(4)20)17-10-7-8-12(21-3)18-14(10)19(11)13/h7-8H,5-6H2,1-4H3
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Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319180
PNG
(4,8-Dimethoxy-1-propyl-imidazo[1,5-a]pyrido[3,2-e]...)
Show SMILES CCCc1ncc2c(OC)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C14H16N4O2/c1-4-5-11-15-8-10-14(20-3)16-9-6-7-12(19-2)17-13(9)18(10)11/h6-8H,4-5H2,1-3H3
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Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319177
PNG
(8-Methoxy-3,4-dimethyl-1-phenethyl-imidazo[1,5-a]p...)
Show SMILES COc1ccc2nc(C)c3c(C)nc(CCc4ccccc4)n3c2n1
Show InChI InChI=1S/C20H20N4O/c1-13-19-14(2)22-17(11-9-15-7-5-4-6-8-15)24(19)20-16(21-13)10-12-18(23-20)25-3/h4-8,10,12H,9,11H2,1-3H3
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Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319176
PNG
(4-Isopropylsulfonylamino-8-methoxy-3-methyl-1-prop...)
Show SMILES CCCc1nc(C)c2c(NS(=O)(=O)C(C)C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C17H23N5O3S/c1-6-7-13-18-11(4)15-16(21-26(23,24)10(2)3)19-12-8-9-14(25-5)20-17(12)22(13)15/h8-10H,6-7H2,1-5H3,(H,19,21)
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Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319175
PNG
(4-Dimethylamino-8-methoxy-3-methyl-1-propyl-imidaz...)
Show SMILES CCCc1nc(C)c2c(nc3ccc(OC)nc3n12)N(C)C
Show InChI InChI=1S/C16H21N5O/c1-6-7-12-17-10(2)14-16(20(3)4)18-11-8-9-13(22-5)19-15(11)21(12)14/h8-9H,6-7H2,1-5H3
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Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319174
PNG
(1-Ethyl-8-methoxy-3-methyl-4-propyloxy-imidazo[1,5...)
Show SMILES CCCOc1nc2ccc(OC)nc2n2c(CC)nc(C)c12
Show InChI InChI=1S/C16H20N4O2/c1-5-9-22-16-14-10(3)17-12(6-2)20(14)15-11(18-16)7-8-13(19-15)21-4/h7-8H,5-6,9H2,1-4H3
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Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319200
PNG
(4-Acetylamino-1-ethyl-8-methoxy-3-methyl-imidazo[1...)
Show SMILES CCc1nc(C)c2c(NC(C)=O)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H17N5O2/c1-5-11-16-8(2)13-14(17-9(3)21)18-10-6-7-12(22-4)19-15(10)20(11)13/h6-7H,5H2,1-4H3,(H,17,18,21)
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Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319172
PNG
(4-Ethoxycarbonylamino-8-methoxy-3-methyl-1-propyl-...)
Show SMILES CCCc1nc(C)c2c(NC(=O)OCC)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C17H21N5O3/c1-5-7-12-18-10(3)14-15(21-17(23)25-6-2)19-11-8-9-13(24-4)20-16(11)22(12)14/h8-9H,5-7H2,1-4H3,(H,19,21,23)
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Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319171
PNG
(8-Methoxy-3-methyl-4-methylsulfanyl-1-propyl-imida...)
Show SMILES CCCc1nc(C)c2c(SC)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H18N4OS/c1-5-6-11-16-9(2)13-15(21-4)17-10-7-8-12(20-3)18-14(10)19(11)13/h7-8H,5-6H2,1-4H3
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Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319170
PNG
(1-Hexyl-8-methoxy-3,4-dimethyl-imidazo[1,5-a]pyrid...)
Show SMILES CCCCCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C18H24N4O/c1-5-6-7-8-9-15-20-13(3)17-12(2)19-14-10-11-16(23-4)21-18(14)22(15)17/h10-11H,5-9H2,1-4H3
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Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50319165
PNG
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Show SMILES CCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3
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n/an/a 239n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of PDE2A


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319202
PNG
(8-Methoxy-3-methyl-4-methylamino-1-propyl-imidazo[...)
Show SMILES CCCc1nc(C)c2c(NC)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H19N5O/c1-5-6-11-17-9(2)13-14(16-3)18-10-7-8-12(21-4)19-15(10)20(11)13/h7-8H,5-6H2,1-4H3,(H,16,18)
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Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319173
PNG
(4,8-Dimethoxy-1,3-dimethyl-imidazo[1,5-a]pyrido[3,...)
Show SMILES COc1ccc2nc(OC)c3c(C)nc(C)n3c2n1
Show InChI InChI=1S/C13H14N4O2/c1-7-11-13(19-4)15-9-5-6-10(18-3)16-12(9)17(11)8(2)14-7/h5-6H,1-4H3
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Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319204
PNG
(1-Ethyl-8-methoxy-3-methyl-4-methylsulfinyl-imidaz...)
Show SMILES CCc1nc(C)c2c(nc3ccc(OC)nc3n12)S(C)=O
Show InChI InChI=1S/C14H16N4O2S/c1-5-10-15-8(2)12-14(21(4)19)16-9-6-7-11(20-3)17-13(9)18(10)12/h6-7H,5H2,1-4H3
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Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319201
PNG
(8-Methoxy-3-methoxycarbonyl-4-methyl-1-propyl-imid...)
Show SMILES CCCc1nc(C(=O)OC)c2c(C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C16H18N4O3/c1-5-6-11-18-13(16(21)23-4)14-9(2)17-10-7-8-12(22-3)19-15(10)20(11)14/h7-8H,5-6H2,1-4H3
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Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319184
PNG
(3-Ethoxycarbonyl-8-methoxy-4-methyl-1-propyl-imida...)
Show SMILES CCCc1nc(C(=O)OCC)c2c(C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C17H20N4O3/c1-5-7-12-19-14(17(22)24-6-2)15-10(3)18-11-8-9-13(23-4)20-16(11)21(12)15/h8-9H,5-7H2,1-4H3
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Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319198
PNG
(4-(N-Isopropyl-ureido)-8-methoxy-3-methyl-1-propyl...)
Show SMILES CCCc1nc(C)c2c(NC(=O)NC(C)C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C18H24N6O2/c1-6-7-13-20-11(4)15-16(23-18(25)19-10(2)3)21-12-8-9-14(26-5)22-17(12)24(13)15/h8-10H,6-7H2,1-5H3,(H2,19,21,23,25)
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Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319203
PNG
(8-Methoxy-3-methyl-4-phenethyloxy-1-propyl-imidazo...)
Show SMILES CCCc1nc(C)c2c(OCCc3ccccc3)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C22H24N4O2/c1-4-8-18-23-15(2)20-22(28-14-13-16-9-6-5-7-10-16)24-17-11-12-19(27-3)25-21(17)26(18)20/h5-7,9-12H,4,8,13-14H2,1-3H3
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Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319178
PNG
(4-Isopropyloxy-8-methoxy-3-methyl-1-propyl-imidazo...)
Show SMILES CCCc1nc(C)c2c(OC(C)C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C17H22N4O2/c1-6-7-13-18-11(4)15-17(23-10(2)3)19-12-8-9-14(22-5)20-16(12)21(13)15/h8-10H,6-7H2,1-5H3
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Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319193
PNG
(4-Acetylamino-8-Methoxy-3-methyl-1-propyl-imidazo[...)
Show SMILES CCCc1nc(C)c2c(NC(C)=O)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C16H19N5O2/c1-5-6-12-17-9(2)14-15(18-10(3)22)19-11-7-8-13(23-4)20-16(11)21(12)14/h7-8H,5-6H2,1-4H3,(H,18,19,22)
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Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319194
PNG
(1-Ethyl-8-methoxy-3-methyl-4-methylamino-imidazo[1...)
Show SMILES CCc1nc(C)c2c(NC)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C14H17N5O/c1-5-10-16-8(2)12-13(15-3)17-9-6-7-11(20-4)18-14(9)19(10)12/h6-7H,5H2,1-4H3,(H,15,17)
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Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319195
PNG
(8-Methoxy-4-(methoxycarbonyl-methyl-amino)-3-methy...)
Show SMILES CCCc1nc(C)c2c(nc3ccc(OC)nc3n12)N(C)C(=O)OC
Show InChI InChI=1S/C17H21N5O3/c1-6-7-12-18-10(2)14-16(21(3)17(23)25-5)19-11-8-9-13(24-4)20-15(11)22(12)14/h8-9H,6-7H2,1-5H3
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n/an/a 486n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319199
PNG
(4-(N-Methyl-ureido)-8-methoxy-3-methyl-1-propyl-im...)
Show SMILES CCCc1nc(C)c2c(NC(=O)NC)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C16H20N6O2/c1-5-6-11-18-9(2)13-14(21-16(23)17-3)19-10-7-8-12(24-4)20-15(10)22(11)13/h7-8H,5-6H2,1-4H3,(H2,17,19,21,23)
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Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50319163
PNG
(8-Methoxy-3-methyl-4-methylsulfonylamino-1-propyl-...)
Show SMILES CCCc1nc(C)c2c(NS(C)(=O)=O)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H19N5O3S/c1-5-6-11-16-9(2)13-14(19-24(4,21)22)17-10-7-8-12(23-3)18-15(10)20(11)13/h7-8H,5-6H2,1-4H3,(H,17,19)
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n/an/a 561n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of PDE5A


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319197
PNG
(1-Ethyl-8-methoxy-3-methyl-4-methylsulfanyl-imidaz...)
Show SMILES CCc1nc(C)c2c(SC)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C14H16N4OS/c1-5-10-15-8(2)12-14(20-4)16-9-6-7-11(19-3)17-13(9)18(10)12/h6-7H,5H2,1-4H3
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Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319179
PNG
(8-Methoxy-3-methyl-4-propylsulfonylamino-1-propyl-...)
Show SMILES CCCc1nc(C)c2c(NS(=O)(=O)CCC)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C17H23N5O3S/c1-5-7-13-18-11(3)15-16(21-26(23,24)10-6-2)19-12-8-9-14(25-4)20-17(12)22(13)15/h8-9H,5-7,10H2,1-4H3,(H,19,21)
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Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319196
PNG
(1-Ethyl-8-methoxy-3-methyl-4-isopropyloxy-imidazo[...)
Show SMILES CCc1nc(C)c2c(OC(C)C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C16H20N4O2/c1-6-12-17-10(4)14-16(22-9(2)3)18-11-7-8-13(21-5)19-15(11)20(12)14/h7-9H,6H2,1-5H3
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Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM50319165
PNG
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Show SMILES CCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3
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n/an/a 779n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of PDE11A


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50319165
PNG
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Show SMILES CCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3
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n/an/a 919n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of PDE5A


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319191
PNG
(8-Methoxy-3-methyl-4-(3-phenyl-propoxy)-1-propyl-i...)
Show SMILES CCCc1nc(C)c2c(OCCCc3ccccc3)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C23H26N4O2/c1-4-9-19-24-16(2)21-23(29-15-8-12-17-10-6-5-7-11-17)25-18-13-14-20(28-3)26-22(18)27(19)21/h5-7,10-11,13-14H,4,8-9,12,15H2,1-3H3
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n/an/a 962n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 7B


(Homo sapiens (Human))
BDBM50319163
PNG
(8-Methoxy-3-methyl-4-methylsulfonylamino-1-propyl-...)
Show SMILES CCCc1nc(C)c2c(NS(C)(=O)=O)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H19N5O3S/c1-5-6-11-16-9(2)13-14(19-24(4,21)22)17-10-7-8-12(23-3)18-15(10)20(11)13/h7-8H,5-6H2,1-4H3,(H,17,19)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of PDE7B


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM50319163
PNG
(8-Methoxy-3-methyl-4-methylsulfonylamino-1-propyl-...)
Show SMILES CCCc1nc(C)c2c(NS(C)(=O)=O)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H19N5O3S/c1-5-6-11-16-9(2)13-14(19-24(4,21)22)17-10-7-8-12(23-3)18-15(10)20(11)13/h7-8H,5-6H2,1-4H3,(H,17,19)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of PDE1B


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50319163
PNG
(8-Methoxy-3-methyl-4-methylsulfonylamino-1-propyl-...)
Show SMILES CCCc1nc(C)c2c(NS(C)(=O)=O)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H19N5O3S/c1-5-6-11-16-9(2)13-14(19-24(4,21)22)17-10-7-8-12(23-3)18-15(10)20(11)13/h7-8H,5-6H2,1-4H3,(H,17,19)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of PDE4A


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50319163
PNG
(8-Methoxy-3-methyl-4-methylsulfonylamino-1-propyl-...)
Show SMILES CCCc1nc(C)c2c(NS(C)(=O)=O)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H19N5O3S/c1-5-6-11-16-9(2)13-14(19-24(4,21)22)17-10-7-8-12(23-3)18-15(10)20(11)13/h7-8H,5-6H2,1-4H3,(H,17,19)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of PDE2A


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (Human))
BDBM50319163
PNG
(8-Methoxy-3-methyl-4-methylsulfonylamino-1-propyl-...)
Show SMILES CCCc1nc(C)c2c(NS(C)(=O)=O)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H19N5O3S/c1-5-6-11-16-9(2)13-14(19-24(4,21)22)17-10-7-8-12(23-3)18-15(10)20(11)13/h7-8H,5-6H2,1-4H3,(H,17,19)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of PDE9A


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (Human))
BDBM50319163
PNG
(8-Methoxy-3-methyl-4-methylsulfonylamino-1-propyl-...)
Show SMILES CCCc1nc(C)c2c(NS(C)(=O)=O)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H19N5O3S/c1-5-6-11-16-9(2)13-14(19-24(4,21)22)17-10-7-8-12(23-3)18-15(10)20(11)13/h7-8H,5-6H2,1-4H3,(H,17,19)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of PDE8A


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319190
PNG
(8-Methoxy-3-methyl-4-propionylamino-1-propyl-imida...)
Show SMILES CCCc1nc(C)c2c(NC(=O)CC)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C17H21N5O2/c1-5-7-12-18-10(3)15-16(20-13(23)6-2)19-11-8-9-14(24-4)21-17(11)22(12)15/h8-9H,5-7H2,1-4H3,(H,19,20,23)
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n/an/a 1.05E+3n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319192
PNG
(8-Methoxy-3-methyl-4-(N-methylsulfonyl-N-methyl-am...)
Show SMILES CCCc1nc(C)c2c(nc3ccc(OC)nc3n12)N(C)S(C)(=O)=O
Show InChI InChI=1S/C16H21N5O3S/c1-6-7-12-17-10(2)14-16(20(3)25(5,22)23)18-11-8-9-13(24-4)19-15(11)21(12)14/h8-9H,6-7H2,1-5H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50319163
PNG
(8-Methoxy-3-methyl-4-methylsulfonylamino-1-propyl-...)
Show SMILES CCCc1nc(C)c2c(NS(C)(=O)=O)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H19N5O3S/c1-5-6-11-16-9(2)13-14(19-24(4,21)22)17-10-7-8-12(23-3)18-15(10)20(11)13/h7-8H,5-6H2,1-4H3,(H,17,19)
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n/an/a 1.26E+3n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of PDE3A


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319189
PNG
(4,8-Dimethoxy-3-methyl-imidazo[1,5-a]pyrido[3,2-e]...)
Show SMILES COc1ccc2nc(OC)c3c(C)ncn3c2n1
Show InChI InChI=1S/C12H12N4O2/c1-7-10-12(18-3)14-8-4-5-9(17-2)15-11(8)16(10)6-13-7/h4-6H,1-3H3
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n/an/a 2.27E+3n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50319188
PNG
(8-Methoxy-1,3-dimethyl-4-methylsulfanyl-imidazo[1,...)
Show SMILES COc1ccc2nc(SC)c3c(C)nc(C)n3c2n1
Show InChI InChI=1S/C13H14N4OS/c1-7-11-13(19-4)15-9-5-6-10(18-3)16-12(9)17(11)8(2)14-7/h5-6H,1-4H3
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n/an/a 2.39E+3n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 7B


(Homo sapiens (Human))
BDBM50319165
PNG
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Show SMILES CCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3
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n/an/a 3.10E+3n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of PDE7B


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50319165
PNG
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Show SMILES CCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3
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n/an/a 3.70E+3n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of PDE3A


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM50319165
PNG
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Show SMILES CCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3
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n/an/a>5.00E+3n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of PDE1B


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50319165
PNG
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Show SMILES CCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3
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n/an/a 5.00E+3n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of PDE4A


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (Human))
BDBM50319165
PNG
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Show SMILES CCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3
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n/an/a>5.00E+3n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of PDE8A


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (Human))
BDBM50319165
PNG
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Show SMILES CCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12
Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3
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n/an/a>5.00E+3n/an/an/an/an/an/a



Biotie Therapies GmbH

Curated by ChEMBL


Assay Description
Inhibition of PDE9A


J Med Chem 53: 4399-411 (2010)


Article DOI: 10.1021/jm1002793
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%