Found 80 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM31592
(PF-2545920 | US9138494, MP-10 | substituted pyraz...)Show SMILES Cn1cc(c(n1)-c1ccc(OCc2ccc3ccccc3n2)cc1)-c1ccncc1 Show InChI InChI=1S/C25H20N4O/c1-29-16-23(18-12-14-26-15-13-18)25(28-29)20-7-10-22(11-8-20)30-17-21-9-6-19-4-2-3-5-24(19)27-21/h2-16H,17H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| Purchase
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| MMDB
PDB
Article
PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319169
(3,4-Dimethoxy-1-isobutyl-8-methoxy-imidazo[1,5-a]p...)Show InChI InChI=1S/C16H20N4O/c1-9(2)8-13-18-11(4)15-10(3)17-12-6-7-14(21-5)19-16(12)20(13)15/h6-7,9H,8H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319168
(1-Cyclohexyl-3,4-dimethyl-8-methoxy-imidazo[1,5-a]...)Show InChI InChI=1S/C18H22N4O/c1-11-16-12(2)20-17(13-7-5-4-6-8-13)22(16)18-14(19-11)9-10-15(21-18)23-3/h9-10,13H,4-8H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319163
(8-Methoxy-3-methyl-4-methylsulfonylamino-1-propyl-...)Show InChI InChI=1S/C15H19N5O3S/c1-5-6-11-16-9(2)13-14(19-24(4,21)22)17-10-7-8-12(23-3)18-15(10)20(11)13/h7-8H,5-6H2,1-4H3,(H,17,19) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 7.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319164
(4-Difluoromethyl-8-methoxy-3-methyl-1-propyl-imida...)Show InChI InChI=1S/C15H16F2N4O/c1-4-5-10-18-8(2)13-12(14(16)17)19-9-6-7-11(22-3)20-15(9)21(10)13/h6-7,14H,4-5H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 7.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319165
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
Article
PubMed
| n/a | n/a | 7.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319166
(1-Propyl-3,4,8-trimethyl-imidazo[1,5-a]pyrido[3,2-...)Show InChI InChI=1S/C15H18N4/c1-5-6-13-18-11(4)14-10(3)17-12-8-7-9(2)16-15(12)19(13)14/h7-8H,5-6H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319159
(4-Cyano-1-cyclohexyl-8-methoxy-3-methyl-imidazo[1,...)Show InChI InChI=1S/C18H19N5O/c1-11-16-14(10-19)21-13-8-9-15(24-2)22-18(13)23(16)17(20-11)12-6-4-3-5-7-12/h8-9,12H,3-7H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 9.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319157
(4-Cyano-8-methoxy-3-methyl-1-propyl-imidazo[1,5-a]...)Show InChI InChI=1S/C15H15N5O/c1-4-5-12-17-9(2)14-11(8-16)18-10-6-7-13(21-3)19-15(10)20(12)14/h6-7H,4-5H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319160
(4-Ethyl-8-methoxy-3-methyl-1-propyl-imidazo[1,5-a]...)Show InChI InChI=1S/C16H20N4O/c1-5-7-13-17-10(3)15-11(6-2)18-12-8-9-14(21-4)19-16(12)20(13)15/h8-9H,5-7H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319162
(8-Difluoromethoxy-3,4-dimethyl-1-propyl-imidazo[1,...)Show InChI InChI=1S/C15H16F2N4O/c1-4-5-11-19-9(3)13-8(2)18-10-6-7-12(22-15(16)17)20-14(10)21(11)13/h6-7,15H,4-5H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319161
(4-(N,N-bis-methylsulfonyl)-8-methoxy-3-methyl-1-pr...)Show SMILES CCCc1nc(C)c2c(nc3ccc(OC)nc3n12)N(S(C)(=O)=O)S(C)(=O)=O Show InChI InChI=1S/C16H21N5O5S2/c1-6-7-12-17-10(2)14-16(21(27(4,22)23)28(5,24)25)18-11-8-9-13(26-3)19-15(11)20(12)14/h8-9H,6-7H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319167
(3,4-Dimethyl-1-ethyl-8-methoxy-imidazo[1,5-a]pyrid...)Show InChI InChI=1S/C14H16N4O/c1-5-11-16-9(3)13-8(2)15-10-6-7-12(19-4)17-14(10)18(11)13/h6-7H,5H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319152
(1-Benzyl-3,4-dimethyl-8-methoxy-imidazo[1,5-a]pyri...)Show InChI InChI=1S/C19H18N4O/c1-12-18-13(2)21-16(11-14-7-5-4-6-8-14)23(18)19-15(20-12)9-10-17(22-19)24-3/h4-10H,11H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319158
(8-Methoxy-3-methyl-4-methylsulfonyl-1-propyl-imida...)Show InChI InChI=1S/C15H18N4O3S/c1-5-6-11-16-9(2)13-15(23(4,20)21)17-10-7-8-12(22-3)18-14(10)19(11)13/h7-8H,5-6H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319155
(8-Methoxy-4-methoxycarbonylamino-3-methyl-1-propyl...)Show InChI InChI=1S/C16H19N5O3/c1-5-6-11-17-9(2)13-14(20-16(22)24-4)18-10-7-8-12(23-3)19-15(10)21(11)13/h7-8H,5-6H2,1-4H3,(H,18,20,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319149
(4,8-Dimethoxy-3-methyl-1-propyl-imidazo[1,5-a]pyri...)Show InChI InChI=1S/C15H18N4O2/c1-5-6-11-16-9(2)13-15(21-4)17-10-7-8-12(20-3)18-14(10)19(11)13/h7-8H,5-6H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319156
(8-Methoxy-4-methyl-1-propyl-imidazo[1,5-a]pyrido[3...)Show InChI InChI=1S/C14H16N4O/c1-4-5-12-15-8-11-9(2)16-10-6-7-13(19-3)17-14(10)18(11)12/h6-8H,4-5H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319148
(3,4-Dimethyl-1-propyl-imidazo[1,5-a]pyrido[3,2-e]p...)Show InChI InChI=1S/C14H16N4/c1-4-6-12-17-10(3)13-9(2)16-11-7-5-8-15-14(11)18(12)13/h5,7-8H,4,6H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319186
(8-Methoxy-3-methyl-1-propyl-imidazo[1,5-a]pyrido[3...)Show InChI InChI=1S/C14H16N4O/c1-4-5-12-16-9(2)11-8-15-10-6-7-13(19-3)17-14(10)18(11)12/h6-8H,4-5H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319185
(4-Cyano-1-ethyl-8-methoxy-3-methyl-imidazo[1,5-a]p...)Show InChI InChI=1S/C14H13N5O/c1-4-11-16-8(2)13-10(7-15)17-9-5-6-12(20-3)18-14(9)19(11)13/h5-6H,4H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319154
(4-Ethylsulfonylamino-8-methoxy-3-methyl-1-propyl-i...)Show SMILES CCCc1nc(C)c2c(NS(=O)(=O)CC)nc3ccc(OC)nc3n12 Show InChI InChI=1S/C16H21N5O3S/c1-5-7-12-17-10(3)14-15(20-25(22,23)6-2)18-11-8-9-13(24-4)19-16(11)21(12)14/h8-9H,5-7H2,1-4H3,(H,18,20) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319153
(8-Methoxy-3-methyl-1-propyl-4-trifluoromethyl-imid...)Show InChI InChI=1S/C15H15F3N4O/c1-4-5-10-19-8(2)12-13(15(16,17)18)20-9-6-7-11(23-3)21-14(9)22(10)12/h6-7H,4-5H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319151
(3,4-Dimethyl-8-methoxy-1-pentyl-imidazo[1,5-a]pyri...)Show InChI InChI=1S/C17H22N4O/c1-5-6-7-8-14-19-12(3)16-11(2)18-13-9-10-15(22-4)20-17(13)21(14)16/h9-10H,5-8H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 51 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319183
(8-Methoxy-3-methyl-1-propyl-4-trifluoromethylsulfo...)Show SMILES CCCc1nc(C)c2c(NS(=O)(=O)C(F)(F)F)nc3ccc(OC)nc3n12 Show InChI InChI=1S/C15H16F3N5O3S/c1-4-5-10-19-8(2)12-13(22-27(24,25)15(16,17)18)20-9-6-7-11(26-3)21-14(9)23(10)12/h6-7H,4-5H2,1-3H3,(H,20,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319182
(8-Methoxy-3-methyl-1-propyl-4-ureido-imidazo[1,5-a...)Show InChI InChI=1S/C15H18N6O2/c1-4-5-10-17-8(2)12-13(20-15(16)22)18-9-6-7-11(23-3)19-14(9)21(10)12/h6-7H,4-5H2,1-3H3,(H3,16,18,20,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM14754
(1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoq...)Show InChI InChI=1S/C20H21NO4/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16/h5-8,10-12H,9H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| DrugBank
PDB
Article
PubMed
| n/a | n/a | 56.9 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM14754
(1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoq...)Show InChI InChI=1S/C20H21NO4/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16/h5-8,10-12H,9H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| DrugBank
PDB
Article
PubMed
| n/a | n/a | 56.9 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319147
(4,8-Dimethoxy-1-ethyl-3-methyl-imidazo[1,5-a]pyrid...)Show InChI InChI=1S/C14H16N4O2/c1-5-10-15-8(2)12-14(20-4)16-9-6-7-11(19-3)17-13(9)18(10)12/h6-7H,5H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319187
(1-Ethyl-8-methoxy-3-methyl-4-methylsulfonylamino-i...)Show InChI InChI=1S/C14H17N5O3S/c1-5-10-15-8(2)12-13(18-23(4,20)21)16-9-6-7-11(22-3)17-14(9)19(10)12/h6-7H,5H2,1-4H3,(H,16,18) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 65 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
(Homo sapiens (Human)) | BDBM50319163
(8-Methoxy-3-methyl-4-methylsulfonylamino-1-propyl-...)Show InChI InChI=1S/C15H19N5O3S/c1-5-6-11-16-9(2)13-14(19-24(4,21)22)17-10-7-8-12(23-3)18-15(10)20(11)13/h7-8H,5-6H2,1-4H3,(H,17,19) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 69 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of PDE11A |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319146
(8-Methoxy-1,3,4-trimethyl-imidazo[1,5-a]pyrido[3,2...)Show InChI InChI=1S/C13H14N4O/c1-7-12-8(2)15-10-5-6-11(18-4)16-13(10)17(12)9(3)14-7/h5-6H,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 81 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319181
(4-(N,N-Bis-ethoxycarbonyl-amino)-8-methoxy-3-methy...)Show SMILES CCCc1nc(C)c2c(nc3ccc(OC)nc3n12)N(C(=O)OC)C(=O)OC Show InChI InChI=1S/C18H21N5O5/c1-6-7-12-19-10(2)14-16(23(17(24)27-4)18(25)28-5)20-11-8-9-13(26-3)21-15(11)22(12)14/h8-9H,6-7H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 82 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319150
(8-Methoxy-3-methyl-4-methylsulfinyl-1-propyl-imida...)Show InChI InChI=1S/C15H18N4O2S/c1-5-6-11-16-9(2)13-15(22(4)20)17-10-7-8-12(21-3)18-14(10)19(11)13/h7-8H,5-6H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319180
(4,8-Dimethoxy-1-propyl-imidazo[1,5-a]pyrido[3,2-e]...)Show InChI InChI=1S/C14H16N4O2/c1-4-5-11-15-8-10-14(20-3)16-9-6-7-12(19-2)17-13(9)18(10)11/h6-8H,4-5H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 92 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319177
(8-Methoxy-3,4-dimethyl-1-phenethyl-imidazo[1,5-a]p...)Show InChI InChI=1S/C20H20N4O/c1-13-19-14(2)22-17(11-9-15-7-5-4-6-8-15)24(19)20-16(21-13)10-12-18(23-20)25-3/h4-8,10,12H,9,11H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 116 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319176
(4-Isopropylsulfonylamino-8-methoxy-3-methyl-1-prop...)Show SMILES CCCc1nc(C)c2c(NS(=O)(=O)C(C)C)nc3ccc(OC)nc3n12 Show InChI InChI=1S/C17H23N5O3S/c1-6-7-13-18-11(4)15-16(21-26(23,24)10(2)3)19-12-8-9-14(25-5)20-17(12)22(13)15/h8-10H,6-7H2,1-5H3,(H,19,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 132 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319175
(4-Dimethylamino-8-methoxy-3-methyl-1-propyl-imidaz...)Show InChI InChI=1S/C16H21N5O/c1-6-7-12-17-10(2)14-16(20(3)4)18-11-8-9-13(22-5)19-15(11)21(12)14/h8-9H,6-7H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 146 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319174
(1-Ethyl-8-methoxy-3-methyl-4-propyloxy-imidazo[1,5...)Show InChI InChI=1S/C16H20N4O2/c1-5-9-22-16-14-10(3)17-12(6-2)20(14)15-11(18-16)7-8-13(19-15)21-4/h7-8H,5-6,9H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 149 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319200
(4-Acetylamino-1-ethyl-8-methoxy-3-methyl-imidazo[1...)Show InChI InChI=1S/C15H17N5O2/c1-5-11-16-8(2)13-14(17-9(3)21)18-10-6-7-12(22-4)19-15(10)20(11)13/h6-7H,5H2,1-4H3,(H,17,18,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 175 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319172
(4-Ethoxycarbonylamino-8-methoxy-3-methyl-1-propyl-...)Show InChI InChI=1S/C17H21N5O3/c1-5-7-12-18-10(3)14-15(21-17(23)25-6-2)19-11-8-9-13(24-4)20-16(11)22(12)14/h8-9H,5-7H2,1-4H3,(H,19,21,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 206 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319171
(8-Methoxy-3-methyl-4-methylsulfanyl-1-propyl-imida...)Show InChI InChI=1S/C15H18N4OS/c1-5-6-11-16-9(2)13-15(21-4)17-10-7-8-12(20-3)18-14(10)19(11)13/h7-8H,5-6H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 209 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319170
(1-Hexyl-8-methoxy-3,4-dimethyl-imidazo[1,5-a]pyrid...)Show InChI InChI=1S/C18H24N4O/c1-5-6-7-8-9-15-20-13(3)17-12(2)19-14-10-11-16(23-4)21-18(14)22(15)17/h10-11H,5-9H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 223 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50319165
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 239 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of PDE2A |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319202
(8-Methoxy-3-methyl-4-methylamino-1-propyl-imidazo[...)Show InChI InChI=1S/C15H19N5O/c1-5-6-11-17-9(2)13-14(16-3)18-10-7-8-12(21-4)19-15(10)20(11)13/h7-8H,5-6H2,1-4H3,(H,16,18) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 246 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319173
(4,8-Dimethoxy-1,3-dimethyl-imidazo[1,5-a]pyrido[3,...)Show InChI InChI=1S/C13H14N4O2/c1-7-11-13(19-4)15-9-5-6-10(18-3)16-12(9)17(11)8(2)14-7/h5-6H,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319204
(1-Ethyl-8-methoxy-3-methyl-4-methylsulfinyl-imidaz...)Show InChI InChI=1S/C14H16N4O2S/c1-5-10-15-8(2)12-14(21(4)19)16-9-6-7-11(20-3)17-13(9)18(10)12/h6-7H,5H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 284 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319201
(8-Methoxy-3-methoxycarbonyl-4-methyl-1-propyl-imid...)Show InChI InChI=1S/C16H18N4O3/c1-5-6-11-18-13(16(21)23-4)14-9(2)17-10-7-8-12(22-3)19-15(10)20(11)14/h7-8H,5-6H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 285 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319184
(3-Ethoxycarbonyl-8-methoxy-4-methyl-1-propyl-imida...)Show InChI InChI=1S/C17H20N4O3/c1-5-7-12-19-14(17(22)24-6-2)15-10(3)18-11-8-9-13(23-4)20-16(11)21(12)15/h8-9H,5-7H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 326 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319198
(4-(N-Isopropyl-ureido)-8-methoxy-3-methyl-1-propyl...)Show SMILES CCCc1nc(C)c2c(NC(=O)NC(C)C)nc3ccc(OC)nc3n12 Show InChI InChI=1S/C18H24N6O2/c1-6-7-13-20-11(4)15-16(23-18(25)19-10(2)3)21-12-8-9-14(26-5)22-17(12)24(13)15/h8-10H,6-7H2,1-5H3,(H2,19,21,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 381 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319203
(8-Methoxy-3-methyl-4-phenethyloxy-1-propyl-imidazo...)Show InChI InChI=1S/C22H24N4O2/c1-4-8-18-23-15(2)20-22(28-14-13-16-9-6-5-7-10-16)24-17-11-12-19(27-3)25-21(17)26(18)20/h5-7,9-12H,4,8,13-14H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 383 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319178
(4-Isopropyloxy-8-methoxy-3-methyl-1-propyl-imidazo...)Show InChI InChI=1S/C17H22N4O2/c1-6-7-13-18-11(4)15-17(23-10(2)3)19-12-8-9-14(22-5)20-16(12)21(13)15/h8-10H,6-7H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 391 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319193
(4-Acetylamino-8-Methoxy-3-methyl-1-propyl-imidazo[...)Show InChI InChI=1S/C16H19N5O2/c1-5-6-12-17-9(2)14-15(18-10(3)22)19-11-7-8-13(23-4)20-16(11)21(12)14/h7-8H,5-6H2,1-4H3,(H,18,19,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 472 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319194
(1-Ethyl-8-methoxy-3-methyl-4-methylamino-imidazo[1...)Show InChI InChI=1S/C14H17N5O/c1-5-10-16-8(2)12-13(15-3)17-9-6-7-11(20-4)18-14(9)19(10)12/h6-7H,5H2,1-4H3,(H,15,17) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 482 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319195
(8-Methoxy-4-(methoxycarbonyl-methyl-amino)-3-methy...)Show InChI InChI=1S/C17H21N5O3/c1-6-7-12-18-10(2)14-16(21(3)17(23)25-5)19-11-8-9-13(24-4)20-15(11)22(12)14/h8-9H,6-7H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 486 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319199
(4-(N-Methyl-ureido)-8-methoxy-3-methyl-1-propyl-im...)Show InChI InChI=1S/C16H20N6O2/c1-5-6-11-18-9(2)13-14(21-16(23)17-3)19-10-7-8-12(24-4)20-15(10)22(11)13/h7-8H,5-6H2,1-4H3,(H2,17,19,21,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 535 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50319163
(8-Methoxy-3-methyl-4-methylsulfonylamino-1-propyl-...)Show InChI InChI=1S/C15H19N5O3S/c1-5-6-11-16-9(2)13-14(19-24(4,21)22)17-10-7-8-12(23-3)18-15(10)20(11)13/h7-8H,5-6H2,1-4H3,(H,17,19) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 561 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of PDE5A |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319197
(1-Ethyl-8-methoxy-3-methyl-4-methylsulfanyl-imidaz...)Show InChI InChI=1S/C14H16N4OS/c1-5-10-15-8(2)12-14(20-4)16-9-6-7-11(19-3)17-13(9)18(10)12/h6-7H,5H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 617 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319179
(8-Methoxy-3-methyl-4-propylsulfonylamino-1-propyl-...)Show SMILES CCCc1nc(C)c2c(NS(=O)(=O)CCC)nc3ccc(OC)nc3n12 Show InChI InChI=1S/C17H23N5O3S/c1-5-7-13-18-11(3)15-16(21-26(23,24)10-6-2)19-12-8-9-14(25-4)20-17(12)22(13)15/h8-9H,5-7,10H2,1-4H3,(H,19,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
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| n/a | n/a | 617 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319196
(1-Ethyl-8-methoxy-3-methyl-4-isopropyloxy-imidazo[...)Show InChI InChI=1S/C16H20N4O2/c1-6-12-17-10(4)14-16(22-9(2)3)18-11-7-8-13(21-5)19-15(11)20(12)14/h7-9H,6H2,1-5H3 | PDB
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| n/a | n/a | 731 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
(Homo sapiens (Human)) | BDBM50319165
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3 | KEGG
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| n/a | n/a | 779 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of PDE11A |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50319165
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3 | PDB
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| n/a | n/a | 919 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of PDE5A |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319191
(8-Methoxy-3-methyl-4-(3-phenyl-propoxy)-1-propyl-i...)Show SMILES CCCc1nc(C)c2c(OCCCc3ccccc3)nc3ccc(OC)nc3n12 Show InChI InChI=1S/C23H26N4O2/c1-4-9-19-24-16(2)21-23(29-15-8-12-17-10-6-5-7-11-17)25-18-13-14-20(28-3)26-22(18)27(19)21/h5-7,10-11,13-14H,4,8-9,12,15H2,1-3H3 | PDB
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Reactome pathway
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| n/a | n/a | 962 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
(Homo sapiens (Human)) | BDBM50319163
(8-Methoxy-3-methyl-4-methylsulfonylamino-1-propyl-...)Show InChI InChI=1S/C15H19N5O3S/c1-5-6-11-16-9(2)13-14(19-24(4,21)22)17-10-7-8-12(23-3)18-15(10)20(11)13/h7-8H,5-6H2,1-4H3,(H,17,19) | PDB
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| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of PDE9A |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
(Homo sapiens (Human)) | BDBM50319163
(8-Methoxy-3-methyl-4-methylsulfonylamino-1-propyl-...)Show InChI InChI=1S/C15H19N5O3S/c1-5-6-11-16-9(2)13-14(19-24(4,21)22)17-10-7-8-12(23-3)18-15(10)20(11)13/h7-8H,5-6H2,1-4H3,(H,17,19) | PDB
MMDB
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| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of PDE1B |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 7B
(Homo sapiens (Human)) | BDBM50319163
(8-Methoxy-3-methyl-4-methylsulfonylamino-1-propyl-...)Show InChI InChI=1S/C15H19N5O3S/c1-5-6-11-16-9(2)13-14(19-24(4,21)22)17-10-7-8-12(23-3)18-15(10)20(11)13/h7-8H,5-6H2,1-4H3,(H,17,19) | Reactome pathway
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| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of PDE7B |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
(Homo sapiens (Human)) | BDBM50319163
(8-Methoxy-3-methyl-4-methylsulfonylamino-1-propyl-...)Show InChI InChI=1S/C15H19N5O3S/c1-5-6-11-16-9(2)13-14(19-24(4,21)22)17-10-7-8-12(23-3)18-15(10)20(11)13/h7-8H,5-6H2,1-4H3,(H,17,19) | PDB
MMDB
Reactome pathway
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| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of PDE8A |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50319163
(8-Methoxy-3-methyl-4-methylsulfonylamino-1-propyl-...)Show InChI InChI=1S/C15H19N5O3S/c1-5-6-11-16-9(2)13-14(19-24(4,21)22)17-10-7-8-12(23-3)18-15(10)20(11)13/h7-8H,5-6H2,1-4H3,(H,17,19) | PDB
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| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of PDE2A |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM50319163
(8-Methoxy-3-methyl-4-methylsulfonylamino-1-propyl-...)Show InChI InChI=1S/C15H19N5O3S/c1-5-6-11-16-9(2)13-14(19-24(4,21)22)17-10-7-8-12(23-3)18-15(10)20(11)13/h7-8H,5-6H2,1-4H3,(H,17,19) | PDB
MMDB
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| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of PDE4A |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319190
(8-Methoxy-3-methyl-4-propionylamino-1-propyl-imida...)Show InChI InChI=1S/C17H21N5O2/c1-5-7-12-18-10(3)15-16(20-13(23)6-2)19-11-8-9-14(24-4)21-17(11)22(12)15/h8-9H,5-7H2,1-4H3,(H,19,20,23) | PDB
MMDB
Reactome pathway
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| CHEMBL
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| n/a | n/a | 1.05E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319192
(8-Methoxy-3-methyl-4-(N-methylsulfonyl-N-methyl-am...)Show SMILES CCCc1nc(C)c2c(nc3ccc(OC)nc3n12)N(C)S(C)(=O)=O Show InChI InChI=1S/C16H21N5O3S/c1-6-7-12-17-10(2)14-16(20(3)25(5,22)23)18-11-8-9-13(24-4)19-15(11)21(12)14/h8-9H,6-7H2,1-5H3 | PDB
MMDB
Reactome pathway
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| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50319163
(8-Methoxy-3-methyl-4-methylsulfonylamino-1-propyl-...)Show InChI InChI=1S/C15H19N5O3S/c1-5-6-11-16-9(2)13-14(19-24(4,21)22)17-10-7-8-12(23-3)18-15(10)20(11)13/h7-8H,5-6H2,1-4H3,(H,17,19) | PDB
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| n/a | n/a | 1.26E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of PDE3A |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319189
(4,8-Dimethoxy-3-methyl-imidazo[1,5-a]pyrido[3,2-e]...)Show InChI InChI=1S/C12H12N4O2/c1-7-10-12(18-3)14-8-4-5-9(17-2)15-11(8)16(10)6-13-7/h4-6H,1-3H3 | PDB
MMDB
Reactome pathway
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| n/a | n/a | 2.27E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50319188
(8-Methoxy-1,3-dimethyl-4-methylsulfanyl-imidazo[1,...)Show InChI InChI=1S/C13H14N4OS/c1-7-11-13(19-4)15-9-5-6-10(18-3)16-12(9)17(11)8(2)14-7/h5-6H,1-4H3 | PDB
MMDB
Reactome pathway
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| n/a | n/a | 2.39E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio... |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 7B
(Homo sapiens (Human)) | BDBM50319165
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3 | Reactome pathway
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| n/a | n/a | 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of PDE7B |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50319165
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3 | PDB
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| n/a | n/a | 3.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of PDE3A |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
(Homo sapiens (Human)) | BDBM50319165
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3 | PDB
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| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of PDE9A |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
(Homo sapiens (Human)) | BDBM50319165
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3 | PDB
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| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of PDE1B |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
(Homo sapiens (Human)) | BDBM50319165
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3 | PDB
MMDB
Reactome pathway
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| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of PDE8A |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM50319165
(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)Show InChI InChI=1S/C15H18N4O/c1-5-6-12-17-10(3)14-9(2)16-11-7-8-13(20-4)18-15(11)19(12)14/h7-8H,5-6H2,1-4H3 | PDB
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Biotie Therapies GmbH
Curated by ChEMBL
| Assay Description
Inhibition of PDE4A |
J Med Chem 53: 4399-411 (2010)
Article DOI: 10.1021/jm1002793
BindingDB Entry DOI: 10.7270/Q2MK6D3N |
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Ligand-Target Pair | |
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