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PubMed code 20541426

Compile data set for download or QSAR
Found 46 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM22542
PNG
(4-(1H-imidazol-4-ylmethyl)piperidine | 4-(1H-imida...)
Show SMILES C(C1CCNCC1)c1cnc[nH]1
Show InChI InChI=1S/C9H15N3/c1-3-10-4-2-8(1)5-9-6-11-7-12-9/h6-8,10H,1-5H2,(H,11,12)
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0.300n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H] (R)-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO cells after 1 hr by liquid scintillation...


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50317865
PNG
(2-(2-(4-tert-Butylphenylthio)ethyl)-1H-imidazole |...)
Show SMILES CC(C)(C)c1ccc(SCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C15H20N2S/c1-15(2,3)12-4-6-14(7-5-12)18-9-8-13-10-16-11-17-13/h4-7,10-11H,8-9H2,1-3H3,(H,16,17)
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0.430n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H] (R)-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO cells after 1 hr by liquid scintillation...


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50321823
PNG
(4-((1H-Imidazol-4-yl)methyl)-1-(3-(trifluoromethyl...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCC(Cc2cnc[nH]2)CC1
Show InChI InChI=1S/C16H18F3N3/c17-16(18,19)13-2-1-3-15(9-13)22-6-4-12(5-7-22)8-14-10-20-11-21-14/h1-3,9-12H,4-8H2,(H,20,21)
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1n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H] (R)-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO cells after 1 hr by liquid scintillation...


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50321813
PNG
(4-((1H-Imidazol-4-yl)methyl)-1-(3-isopropylphenyl)...)
Show SMILES CC(C)c1cccc(c1)N1CCC(Cc2cnc[nH]2)CC1
Show InChI InChI=1S/C18H25N3/c1-14(2)16-4-3-5-18(11-16)21-8-6-15(7-9-21)10-17-12-19-13-20-17/h3-5,11-15H,6-10H2,1-2H3,(H,19,20)
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1n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H] (R)-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO cells after 1 hr by liquid scintillation...


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50317865
PNG
(2-(2-(4-tert-Butylphenylthio)ethyl)-1H-imidazole |...)
Show SMILES CC(C)(C)c1ccc(SCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C15H20N2S/c1-15(2,3)12-4-6-14(7-5-12)18-9-8-13-10-16-11-17-13/h4-7,10-11H,8-9H2,1-3H3,(H,16,17)
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1.10n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation counting


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50321827
PNG
(4-(4-((1H-Imidazol-4-yl)methyl)piperidin-1-yl)-N,N...)
Show SMILES CN(C)c1ccc(cc1)N1CCC(Cc2cnc[nH]2)CC1
Show InChI InChI=1S/C17H24N4/c1-20(2)16-3-5-17(6-4-16)21-9-7-14(8-10-21)11-15-12-18-13-19-15/h3-6,12-14H,7-11H2,1-2H3,(H,18,19)
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1.40n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H] (R)-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO cells after 1 hr by liquid scintillation...


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50321826
PNG
(4-(4-((1H-Imidazol-4-yl)methyl)piperidin-1-yl)-N-m...)
Show SMILES CNc1ccc(cc1)N1CCC(Cc2cnc[nH]2)CC1
Show InChI InChI=1S/C16H22N4/c1-17-14-2-4-16(5-3-14)20-8-6-13(7-9-20)10-15-11-18-12-19-15/h2-5,11-13,17H,6-10H2,1H3,(H,18,19)
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1.60n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H] (R)-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO cells after 1 hr by liquid scintillation...


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50321815
PNG
(4-((1H-Imidazol-4-yl)methyl)-1-(4-(trifluoromethyl...)
Show SMILES FC(F)(F)c1ccc(cc1)N1CCC(Cc2cnc[nH]2)CC1
Show InChI InChI=1S/C16H18F3N3/c17-16(18,19)13-1-3-15(4-2-13)22-7-5-12(6-8-22)9-14-10-20-11-21-14/h1-4,10-12H,5-9H2,(H,20,21)
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1.80n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H] (R)-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO cells after 1 hr by liquid scintillation...


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50321816
PNG
(4-((1H-Imidazol-4-yl)methyl)-1-(4-methoxyphenyl)pi...)
Show SMILES COc1ccc(cc1)N1CCC(Cc2cnc[nH]2)CC1
Show InChI InChI=1S/C16H21N3O/c1-20-16-4-2-15(3-5-16)19-8-6-13(7-9-19)10-14-11-17-12-18-14/h2-5,11-13H,6-10H2,1H3,(H,17,18)
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5.40n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H] (R)-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO cells after 1 hr by liquid scintillation...


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50321821
PNG
(4-((1H-Imidazol-4-yl)methyl)-1-(4-fluorophenyl)pip...)
Show SMILES Fc1ccc(cc1)N1CCC(Cc2cnc[nH]2)CC1
Show InChI InChI=1S/C15H18FN3/c16-13-1-3-15(4-2-13)19-7-5-12(6-8-19)9-14-10-17-11-18-14/h1-4,10-12H,5-9H2,(H,17,18)
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12n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H] (R)-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO cells after 1 hr by liquid scintillation...


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50321824
PNG
(4-((1H-Imidazol-4-yl)methyl)-1-(4-isopropylphenyl)...)
Show SMILES CC(C)c1ccc(cc1)N1CCC(Cc2cnc[nH]2)CC1
Show InChI InChI=1S/C18H25N3/c1-14(2)16-3-5-18(6-4-16)21-9-7-15(8-10-21)11-17-12-19-13-20-17/h3-6,12-15H,7-11H2,1-2H3,(H,19,20)
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14n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H] (R)-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO cells after 1 hr by liquid scintillation...


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50321825
PNG
(4-((1H-Imidazol-4-yl)methyl)-1-(4-tert-butylphenyl...)
Show SMILES CC(C)(C)c1ccc(cc1)N1CCC(Cc2cnc[nH]2)CC1
Show InChI InChI=1S/C19H27N3/c1-19(2,3)16-4-6-18(7-5-16)22-10-8-15(9-11-22)12-17-13-20-14-21-17/h4-7,13-15H,8-12H2,1-3H3,(H,20,21)
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14n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H] (R)-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO cells after 1 hr by liquid scintillation...


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50321828
PNG
(4-((1H-Imidazol-4-yl)methyl)-1-(naphthalen-2-yl)pi...)
Show SMILES C(C1CCN(CC1)c1ccc2ccccc2c1)c1cnc[nH]1
Show InChI InChI=1S/C19H21N3/c1-2-4-17-12-19(6-5-16(17)3-1)22-9-7-15(8-10-22)11-18-13-20-14-21-18/h1-6,12-15H,7-11H2,(H,20,21)
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16n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H] (R)-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO cells after 1 hr by liquid scintillation...


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50321822
PNG
(4-((1H-Imidazol-4-yl)methyl)-1-(4-nitrophenyl)pipe...)
Show SMILES [O-][N+](=O)c1ccc(cc1)N1CCC(Cc2cnc[nH]2)CC1
Show InChI InChI=1S/C15H18N4O2/c20-19(21)15-3-1-14(2-4-15)18-7-5-12(6-8-18)9-13-10-16-11-17-13/h1-4,10-12H,5-9H2,(H,16,17)
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20n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H] (R)-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO cells after 1 hr by liquid scintillation...


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM22542
PNG
(4-(1H-imidazol-4-ylmethyl)piperidine | 4-(1H-imida...)
Show SMILES C(C1CCNCC1)c1cnc[nH]1
Show InChI InChI=1S/C9H15N3/c1-3-10-4-2-8(1)5-9-6-11-7-12-9/h6-8,10H,1-5H2,(H,11,12)
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22n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation counting


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50321820
PNG
(4-((1H-Imidazol-4-yl)methyl)-1-phenylpiperidine | ...)
Show SMILES C(C1CCN(CC1)c1ccccc1)c1cnc[nH]1
Show InChI InChI=1S/C15H19N3/c1-2-4-15(5-3-1)18-8-6-13(7-9-18)10-14-11-16-12-17-14/h1-5,11-13H,6-10H2,(H,16,17)
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30n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H] (R)-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO cells after 1 hr by liquid scintillation...


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50321814
PNG
(4-((1H-Imidazol-4-yl)methyl)-1-(biphenyl-4-yl)pipe...)
Show SMILES C(C1CCN(CC1)c1ccc(cc1)-c1ccccc1)c1cnc[nH]1
Show InChI InChI=1S/C21H23N3/c1-2-4-18(5-3-1)19-6-8-21(9-7-19)24-12-10-17(11-13-24)14-20-15-22-16-23-20/h1-9,15-17H,10-14H2,(H,22,23)
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61n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H] (R)-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO cells after 1 hr by liquid scintillation...


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50321829
PNG
(3-(4-((1H-Imidazol-4-yl)methyl)piperidin-1-yl)pyri...)
Show SMILES C(C1CCN(CC1)c1cccnc1)c1cnc[nH]1
Show InChI InChI=1S/C14H18N4/c1-2-14(10-15-5-1)18-6-3-12(4-7-18)8-13-9-16-11-17-13/h1-2,5,9-12H,3-4,6-8H2,(H,16,17)
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127n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H] (R)-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO cells after 1 hr by liquid scintillation...


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50321815
PNG
(4-((1H-Imidazol-4-yl)methyl)-1-(4-(trifluoromethyl...)
Show SMILES FC(F)(F)c1ccc(cc1)N1CCC(Cc2cnc[nH]2)CC1
Show InChI InChI=1S/C16H18F3N3/c17-16(18,19)13-1-3-15(4-2-13)22-7-5-12(6-8-22)9-14-10-20-11-21-14/h1-4,10-12H,5-9H2,(H,20,21)
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216n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation counting


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50321817
PNG
(1-((1H-Imidazol-4-yl)methyl)-4-phenylpiperazine | ...)
Show SMILES C(N1CCN(CC1)c1ccccc1)c1cnc[nH]1
Show InChI InChI=1S/C14H18N4/c1-2-4-14(5-3-1)18-8-6-17(7-9-18)11-13-10-15-12-16-13/h1-5,10,12H,6-9,11H2,(H,15,16)
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>1.00E+3n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H] (R)-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO cells after 1 hr by liquid scintillation...


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50317865
PNG
(2-(2-(4-tert-Butylphenylthio)ethyl)-1H-imidazole |...)
Show SMILES CC(C)(C)c1ccc(SCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C15H20N2S/c1-15(2,3)12-4-6-14(7-5-12)18-9-8-13-10-16-11-17-13/h4-7,10-11H,8-9H2,1-3H3,(H,16,17)
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>1.00E+3n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]aminopotentidine from human histamine H2 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation counting


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50321816
PNG
(4-((1H-Imidazol-4-yl)methyl)-1-(4-methoxyphenyl)pi...)
Show SMILES COc1ccc(cc1)N1CCC(Cc2cnc[nH]2)CC1
Show InChI InChI=1S/C16H21N3O/c1-20-16-4-2-15(3-5-16)19-8-6-13(7-9-19)10-14-11-17-12-18-14/h2-5,11-13H,6-10H2,1H3,(H,17,18)
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>1.00E+3n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]aminopotentidine from human histamine H2 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation counting


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM22542
PNG
(4-(1H-imidazol-4-ylmethyl)piperidine | 4-(1H-imida...)
Show SMILES C(C1CCNCC1)c1cnc[nH]1
Show InChI InChI=1S/C9H15N3/c1-3-10-4-2-8(1)5-9-6-11-7-12-9/h6-8,10H,1-5H2,(H,11,12)
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>1.00E+3n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]aminopotentidine from human histamine H2 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation counting


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50321816
PNG
(4-((1H-Imidazol-4-yl)methyl)-1-(4-methoxyphenyl)pi...)
Show SMILES COc1ccc(cc1)N1CCC(Cc2cnc[nH]2)CC1
Show InChI InChI=1S/C16H21N3O/c1-20-16-4-2-15(3-5-16)19-8-6-13(7-9-19)10-14-11-17-12-18-14/h2-5,11-13H,6-10H2,1H3,(H,17,18)
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>1.00E+3n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]rilamine from human histamine H1 receptor expressed in CHO cells after 1 hr by liquid scintillation counting


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50321815
PNG
(4-((1H-Imidazol-4-yl)methyl)-1-(4-(trifluoromethyl...)
Show SMILES FC(F)(F)c1ccc(cc1)N1CCC(Cc2cnc[nH]2)CC1
Show InChI InChI=1S/C16H18F3N3/c17-16(18,19)13-1-3-15(4-2-13)22-7-5-12(6-8-22)9-14-10-20-11-21-14/h1-4,10-12H,5-9H2,(H,20,21)
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>1.00E+3n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]aminopotentidine from human histamine H2 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation counting


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50321815
PNG
(4-((1H-Imidazol-4-yl)methyl)-1-(4-(trifluoromethyl...)
Show SMILES FC(F)(F)c1ccc(cc1)N1CCC(Cc2cnc[nH]2)CC1
Show InChI InChI=1S/C16H18F3N3/c17-16(18,19)13-1-3-15(4-2-13)22-7-5-12(6-8-22)9-14-10-20-11-21-14/h1-4,10-12H,5-9H2,(H,20,21)
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>1.00E+3n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]rilamine from human histamine H1 receptor expressed in CHO cells after 1 hr by liquid scintillation counting


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50321819
PNG
(1-((1H-Imidazol-4-yl)methyl)-4-(4-tert-butylphenyl...)
Show SMILES CC(C)(C)c1ccc(cc1)N1CCN(Cc2cnc[nH]2)CC1
Show InChI InChI=1S/C18H26N4/c1-18(2,3)15-4-6-17(7-5-15)22-10-8-21(9-11-22)13-16-12-19-14-20-16/h4-7,12,14H,8-11,13H2,1-3H3,(H,19,20)
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>1.00E+3n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H] (R)-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO cells after 1 hr by liquid scintillation...


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50317865
PNG
(2-(2-(4-tert-Butylphenylthio)ethyl)-1H-imidazole |...)
Show SMILES CC(C)(C)c1ccc(SCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C15H20N2S/c1-15(2,3)12-4-6-14(7-5-12)18-9-8-13-10-16-11-17-13/h4-7,10-11H,8-9H2,1-3H3,(H,16,17)
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>1.00E+3n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]rilamine from human histamine H1 receptor expressed in CHO cells after 1 hr by liquid scintillation counting


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50321818
PNG
(1-((1H-Imidazol-4-yl)methyl)-4-(4-trifluoromethylp...)
Show SMILES FC(F)(F)c1ccc(cc1)N1CCN(Cc2cnc[nH]2)CC1
Show InChI InChI=1S/C15H17F3N4/c16-15(17,18)12-1-3-14(4-2-12)22-7-5-21(6-8-22)10-13-9-19-11-20-13/h1-4,9,11H,5-8,10H2,(H,19,20)
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>1.00E+3n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H] (R)-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO cells after 1 hr by liquid scintillation...


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50321816
PNG
(4-((1H-Imidazol-4-yl)methyl)-1-(4-methoxyphenyl)pi...)
Show SMILES COc1ccc(cc1)N1CCC(Cc2cnc[nH]2)CC1
Show InChI InChI=1S/C16H21N3O/c1-20-16-4-2-15(3-5-16)19-8-6-13(7-9-19)10-14-11-17-12-18-14/h2-5,11-13H,6-10H2,1H3,(H,17,18)
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3.10E+3n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation counting


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50321813
PNG
(4-((1H-Imidazol-4-yl)methyl)-1-(3-isopropylphenyl)...)
Show SMILES CC(C)c1cccc(c1)N1CCC(Cc2cnc[nH]2)CC1
Show InChI InChI=1S/C18H25N3/c1-14(2)16-4-3-5-18(11-16)21-8-6-15(7-9-21)10-17-12-19-13-20-17/h3-5,11-15H,6-10H2,1-2H3,(H,19,20)
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n/an/a 6.60n/an/an/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant histamine H3 receptor expressed in CHO-K1 cells assessed as inhibition of RAHM-induced [35S]GTPgammaS bindin...


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50321814
PNG
(4-((1H-Imidazol-4-yl)methyl)-1-(biphenyl-4-yl)pipe...)
Show SMILES C(C1CCN(CC1)c1ccc(cc1)-c1ccccc1)c1cnc[nH]1
Show InChI InChI=1S/C21H23N3/c1-2-4-18(5-3-1)19-6-8-21(9-7-19)24-12-10-17(11-13-24)14-20-15-22-16-23-20/h1-9,15-17H,10-14H2,(H,22,23)
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n/an/a 347n/an/an/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant histamine H3 receptor expressed in CHO-K1 cells assessed as inhibition of RAHM-induced [35S]GTPgammaS bindin...


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50321822
PNG
(4-((1H-Imidazol-4-yl)methyl)-1-(4-nitrophenyl)pipe...)
Show SMILES [O-][N+](=O)c1ccc(cc1)N1CCC(Cc2cnc[nH]2)CC1
Show InChI InChI=1S/C15H18N4O2/c20-19(21)15-3-1-14(2-4-15)18-7-5-12(6-8-18)9-13-10-16-11-17-13/h1-4,10-12H,5-9H2,(H,16,17)
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n/an/an/an/a 8.80n/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant histamine H3 receptor expressed in CHO-K1 cells assessed as [35S]GTPgammaS binding after 1 hr by liquid scintil...


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50321821
PNG
(4-((1H-Imidazol-4-yl)methyl)-1-(4-fluorophenyl)pip...)
Show SMILES Fc1ccc(cc1)N1CCC(Cc2cnc[nH]2)CC1
Show InChI InChI=1S/C15H18FN3/c16-13-1-3-15(4-2-13)19-7-5-12(6-8-19)9-14-10-17-11-18-14/h1-4,10-12H,5-9H2,(H,17,18)
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n/an/an/an/a 1.10n/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant histamine H3 receptor expressed in CHO-K1 cells assessed as [35S]GTPgammaS binding after 1 hr by liquid scintil...


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50321827
PNG
(4-(4-((1H-Imidazol-4-yl)methyl)piperidin-1-yl)-N,N...)
Show SMILES CN(C)c1ccc(cc1)N1CCC(Cc2cnc[nH]2)CC1
Show InChI InChI=1S/C17H24N4/c1-20(2)16-3-5-17(6-4-16)21-9-7-14(8-10-21)11-15-12-18-13-19-15/h3-6,12-14H,7-11H2,1-2H3,(H,18,19)
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n/an/an/an/a 2n/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant histamine H3 receptor expressed in CHO-K1 cells assessed as [35S]GTPgammaS binding after 1 hr by liquid scintil...


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50321825
PNG
(4-((1H-Imidazol-4-yl)methyl)-1-(4-tert-butylphenyl...)
Show SMILES CC(C)(C)c1ccc(cc1)N1CCC(Cc2cnc[nH]2)CC1
Show InChI InChI=1S/C19H27N3/c1-19(2,3)16-4-6-18(7-5-16)22-10-8-15(9-11-22)12-17-13-20-14-21-17/h4-7,13-15H,8-12H2,1-3H3,(H,20,21)
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n/an/an/an/a 18n/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant histamine H3 receptor expressed in CHO-K1 cells assessed as [35S]GTPgammaS binding after 1 hr by liquid scintil...


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50321826
PNG
(4-(4-((1H-Imidazol-4-yl)methyl)piperidin-1-yl)-N-m...)
Show SMILES CNc1ccc(cc1)N1CCC(Cc2cnc[nH]2)CC1
Show InChI InChI=1S/C16H22N4/c1-17-14-2-4-16(5-3-14)20-8-6-13(7-9-20)10-15-11-18-12-19-15/h2-5,11-13,17H,6-10H2,1H3,(H,18,19)
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n/an/an/an/a 1.70n/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant histamine H3 receptor expressed in CHO-K1 cells assessed as [35S]GTPgammaS binding after 1 hr by liquid scintil...


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM22542
PNG
(4-(1H-imidazol-4-ylmethyl)piperidine | 4-(1H-imida...)
Show SMILES C(C1CCNCC1)c1cnc[nH]1
Show InChI InChI=1S/C9H15N3/c1-3-10-4-2-8(1)5-9-6-11-7-12-9/h6-8,10H,1-5H2,(H,11,12)
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n/an/an/an/a 0.670n/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant histamine H3 receptor expressed in CHO-K1 cells assessed as [35S]GTPgammaS binding after 1 hr by liquid scintil...


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50321823
PNG
(4-((1H-Imidazol-4-yl)methyl)-1-(3-(trifluoromethyl...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCC(Cc2cnc[nH]2)CC1
Show InChI InChI=1S/C16H18F3N3/c17-16(18,19)13-2-1-3-15(9-13)22-6-4-12(5-7-22)8-14-10-20-11-21-14/h1-3,9-12H,4-8H2,(H,20,21)
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n/an/an/an/a 0.210n/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant histamine H3 receptor expressed in CHO-K1 cells assessed as [35S]GTPgammaS binding after 1 hr by liquid scintil...


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50321828
PNG
(4-((1H-Imidazol-4-yl)methyl)-1-(naphthalen-2-yl)pi...)
Show SMILES C(C1CCN(CC1)c1ccc2ccccc2c1)c1cnc[nH]1
Show InChI InChI=1S/C19H21N3/c1-2-4-17-12-19(6-5-16(17)3-1)22-9-7-15(8-10-22)11-18-13-20-14-21-18/h1-6,12-15H,7-11H2,(H,20,21)
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n/an/an/an/a 1.60n/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant histamine H3 receptor expressed in CHO-K1 cells assessed as [35S]GTPgammaS binding after 1 hr by liquid scintil...


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50321820
PNG
(4-((1H-Imidazol-4-yl)methyl)-1-phenylpiperidine | ...)
Show SMILES C(C1CCN(CC1)c1ccccc1)c1cnc[nH]1
Show InChI InChI=1S/C15H19N3/c1-2-4-15(5-3-1)18-8-6-13(7-9-18)10-14-11-16-12-17-14/h1-5,11-13H,6-10H2,(H,16,17)
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n/an/an/an/a 41n/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant histamine H3 receptor expressed in CHO-K1 cells assessed as [35S]GTPgammaS binding after 1 hr by liquid scintil...


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50317865
PNG
(2-(2-(4-tert-Butylphenylthio)ethyl)-1H-imidazole |...)
Show SMILES CC(C)(C)c1ccc(SCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C15H20N2S/c1-15(2,3)12-4-6-14(7-5-12)18-9-8-13-10-16-11-17-13/h4-7,10-11H,8-9H2,1-3H3,(H,16,17)
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n/an/an/an/a 0.75n/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant histamine H3 receptor expressed in CHO-K1 cells assessed as [35S]GTPgammaS binding after 1 hr by liquid scintil...


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50321816
PNG
(4-((1H-Imidazol-4-yl)methyl)-1-(4-methoxyphenyl)pi...)
Show SMILES COc1ccc(cc1)N1CCC(Cc2cnc[nH]2)CC1
Show InChI InChI=1S/C16H21N3O/c1-20-16-4-2-15(3-5-16)19-8-6-13(7-9-19)10-14-11-17-12-18-14/h2-5,11-13H,6-10H2,1H3,(H,17,18)
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n/an/an/an/a 7.60n/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant histamine H3 receptor expressed in CHO-K1 cells assessed as [35S]GTPgammaS binding after 1 hr by liquid scintil...


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50321829
PNG
(3-(4-((1H-Imidazol-4-yl)methyl)piperidin-1-yl)pyri...)
Show SMILES C(C1CCN(CC1)c1cccnc1)c1cnc[nH]1
Show InChI InChI=1S/C14H18N4/c1-2-14(10-15-5-1)18-6-3-12(4-7-18)8-13-9-16-11-17-13/h1-2,5,9-12H,3-4,6-8H2,(H,16,17)
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n/an/an/an/a 177n/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant histamine H3 receptor expressed in CHO-K1 cells assessed as [35S]GTPgammaS binding after 1 hr by liquid scintil...


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50321815
PNG
(4-((1H-Imidazol-4-yl)methyl)-1-(4-(trifluoromethyl...)
Show SMILES FC(F)(F)c1ccc(cc1)N1CCC(Cc2cnc[nH]2)CC1
Show InChI InChI=1S/C16H18F3N3/c17-16(18,19)13-1-3-15(4-2-13)22-7-5-12(6-8-22)9-14-10-20-11-21-14/h1-4,10-12H,5-9H2,(H,20,21)
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n/an/an/an/a 1.10n/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant histamine H3 receptor expressed in CHO-K1 cells assessed as [35S]GTPgammaS binding after 1 hr by liquid scintil...


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50321824
PNG
(4-((1H-Imidazol-4-yl)methyl)-1-(4-isopropylphenyl)...)
Show SMILES CC(C)c1ccc(cc1)N1CCC(Cc2cnc[nH]2)CC1
Show InChI InChI=1S/C18H25N3/c1-14(2)16-3-5-18(6-4-16)21-9-7-15(8-10-21)11-17-12-19-13-20-17/h3-6,12-15H,7-11H2,1-2H3,(H,19,20)
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n/an/an/an/a 12n/an/an/an/a



Meiji Seika Kaisha, Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant histamine H3 receptor expressed in CHO-K1 cells assessed as [35S]GTPgammaS binding after 1 hr by liquid scintil...


Bioorg Med Chem 18: 5441-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.052
BindingDB Entry DOI: 10.7270/Q2C82B88
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%