Affinity Data by PubMed id=20561787

PubMed code 20561787

Found 46 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Serine/threonine-protein kinase Chk2 (Homo sapiens (Human))	BDBM50321650 ((4-(3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)...) Show SMILES NCc1ccc(cc1)-c1cn2c(cnc2cn1)-c1cn[nH]c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of CHK2 by DELFIA assay				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM50321650 ((4-(3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)...) Show SMILES NCc1ccc(cc1)-c1cn2c(cnc2cn1)-c1cn[nH]c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of ABL1 by Z-lite assay				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM50321651 ((4-(3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)...) Show SMILES OCc1ccc(cc1)-c1cn2c(cnc2cn1)-c1cn[nH]c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of ABL1 by Z-lite assay				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM50321649 (3,6-di(1H-pyrazol-4-yl)imidazo[1,2-a]pyrimidine \| ...) Show SMILES c1n[nH]cc1-c1cnc2ncc(cn12)-c1cn[nH]c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	440	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of ABL1 by Z-lite assay				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk2 (Homo sapiens (Human))	BDBM50321654 (3-(1H-pyrazol-3-yl)-6-(1H-pyrazol-4-yl)imidazo[1,2...) Show SMILES c1cc(n[nH]1)-c1cnc2ncc(cn12)-c1cn[nH]c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of CHK2 by DELFIA assay				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk2 (Homo sapiens (Human))	BDBM50321655 (3-(1H-indol-3-yl)-6-(1H-pyrazol-4-yl)imidazo[1,2-a...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of CHK2 by DELFIA assay				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50321654 (3-(1H-pyrazol-3-yl)-6-(1H-pyrazol-4-yl)imidazo[1,2...) Show SMILES c1cc(n[nH]1)-c1cnc2ncc(cn12)-c1cn[nH]c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of CHK1 by DELFIA				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk2 (Homo sapiens (Human))	BDBM50321656 ((3-(3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)...) Show SMILES OCc1cccc(c1)-c1cn2c(cnc2cn1)-c1cn[nH]c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of CHK2 by DELFIA assay				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50321650 ((4-(3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)...) Show SMILES NCc1ccc(cc1)-c1cn2c(cnc2cn1)-c1cn[nH]c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of CHK1 by DELFIA				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Serine/threonine-protein kinase Chk2 (Homo sapiens (Human))	BDBM50321651 ((4-(3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)...) Show SMILES OCc1ccc(cc1)-c1cn2c(cnc2cn1)-c1cn[nH]c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of CHK2 by DELFIA assay				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50321657 (3-phenyl-6-(pyridin-4-yl)imidazo[1,2-a]pyrazine \| ...) Show SMILES c1nc2cnc(cn2c1-c1ccccc1)-c1ccncc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of GSK3-beta at 10 uM by mobility shift assay				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50321681 ((3-(3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)...) Show SMILES NCc1cccc(c1)-c1cn2c(cnc2cn1)-c1cn[nH]c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of CHK1 by DELFIA				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50321649 (3,6-di(1H-pyrazol-4-yl)imidazo[1,2-a]pyrimidine \| ...) Show SMILES c1n[nH]cc1-c1cnc2ncc(cn12)-c1cn[nH]c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of CHK1 by DELFIA				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50321655 (3-(1H-indol-3-yl)-6-(1H-pyrazol-4-yl)imidazo[1,2-a...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	5.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of GSK3-beta at 10 uM by mobility shift assay				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk2 (Homo sapiens (Human))	BDBM50321652 (3-PHENYL-6-(1H-PYRAZOL-4-YL)IMIDAZO[1,2-A]PYRAZINE...) Show SMILES c1n[nH]cc1-c1cn2c(cnc2cn1)-c1ccccc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of CHK2 by DELFIA assay				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50321655 (3-(1H-indol-3-yl)-6-(1H-pyrazol-4-yl)imidazo[1,2-a...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	6.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of CHK1 by DELFIA				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase Chk2 (Homo sapiens (Human))	BDBM50321649 (3,6-di(1H-pyrazol-4-yl)imidazo[1,2-a]pyrimidine \| ...) Show SMILES c1n[nH]cc1-c1cnc2ncc(cn12)-c1cn[nH]c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of CHK2 by DELFIA assay				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk2 (Homo sapiens (Human))	BDBM50321653 (3-(1-methyl-1H-pyrazol-4-yl)-6-(1H-pyrazol-4-yl)im...) Show SMILES Cn1cc(cn1)-c1cnc2ncc(cn12)-c1cn[nH]c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of CHK2 by DELFIA assay				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50321678 (6-(5-methyl-1H-pyrazol-4-yl)-3-(1H-pyrazol-4-yl)im...) Show SMILES Cc1[nH]ncc1-c1cn2c(cnc2cn1)-c1cn[nH]c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of CHK1 by DELFIA				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50321679 (4-(3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)a...) Show SMILES Nc1ccc(cc1)-c1cn2c(cnc2cn1)-c1cn[nH]c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of CHK1 by DELFIA				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50321677 (6-phenyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazine...) Show SMILES c1n[nH]cc1-c1cnc2cnc(cn12)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of CHK1 by DELFIA				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50321669 (4-(4-(6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrimidin-3...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of CHK1 by DELFIA				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50321653 (3-(1-methyl-1H-pyrazol-4-yl)-6-(1H-pyrazol-4-yl)im...) Show SMILES Cn1cc(cn1)-c1cnc2ncc(cn12)-c1cn[nH]c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of CHK1 by DELFIA				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50321668 (4-(3-(6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrimidin-3...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of CHK1 by DELFIA				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50321676 (3-(1H-pyrazol-4-yl)-6-(pyridin-4-yl)imidazo[1,2-a]...) Show SMILES c1n[nH]cc1-c1cnc2cnc(cn12)-c1ccncc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of CHK1 by DELFIA				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50321673 (4-(6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-3-yl)a...) Show SMILES Nc1ccc(cc1)-c1cnc2cnc(cn12)-c1cn[nH]c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of CHK1 by DELFIA				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50321680 (3-(3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)a...) Show SMILES Nc1cccc(c1)-c1cn2c(cnc2cn1)-c1cn[nH]c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of CHK1 by DELFIA				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50321656 ((3-(3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)...) Show SMILES OCc1cccc(c1)-c1cn2c(cnc2cn1)-c1cn[nH]c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of CHK1 by DELFIA				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50321652 (3-PHENYL-6-(1H-PYRAZOL-4-YL)IMIDAZO[1,2-A]PYRAZINE...) Show SMILES c1n[nH]cc1-c1cn2c(cnc2cn1)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of CHK1 by DELFIA				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50321651 ((4-(3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)...) Show SMILES OCc1ccc(cc1)-c1cn2c(cnc2cn1)-c1cn[nH]c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of CHK1 by DELFIA				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50321675 (6-(1H-pyrazol-4-yl)-3-(1H-pyrrol-2-yl)imidazo[1,2-...) Show SMILES c1c[nH]c(c1)-c1cnc2cnc(cn12)-c1cn[nH]c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of CHK1 by DELFIA				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50321667 ((3-(6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrimidin-3-y...) Show SMILES OCc1cccc(c1)-c1cnc2ncc(cn12)-c1cn[nH]c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of CHK1 by DELFIA				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50321657 (3-phenyl-6-(pyridin-4-yl)imidazo[1,2-a]pyrazine \| ...) Show SMILES c1nc2cnc(cn2c1-c1ccccc1)-c1ccncc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of CHK1 by DELFIA				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50321659 (6-(1-methyl-1H-pyrazol-4-yl)-3-phenylimidazo[1,2-a...) Show SMILES Cn1cc(cn1)-c1cn2c(cnc2cn1)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of CHK1 by DELFIA				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50321674 ((4-(6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-3-yl)...) Show SMILES OCc1ccc(cc1)-c1cnc2cnc(cn12)-c1cn[nH]c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of CHK1 by DELFIA				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50321670 (4-(6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-3-yl)b...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of CHK1 by DELFIA				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50321663 (3-phenyl-6-(pyridin-2-yl)imidazo[1,2-a]pyrazine \| ...) Show SMILES c1nc2cnc(cn2c1-c1ccccc1)-c1ccccn1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of CHK1 by DELFIA				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50321658 (3-phenyl-6-(1H-pyrazol-3-yl)imidazo[1,2-a]pyrazine...) Show SMILES c1cc(n[nH]1)-c1cn2c(cnc2cn1)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of CHK1 by DELFIA				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50321661 (3-phenyl-6-(1H-pyrrol-2-yl)imidazo[1,2-a]pyrazine ...) Show SMILES c1c[nH]c(c1)-c1cn2c(cnc2cn1)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of CHK1 by DELFIA				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50321672 (3-(6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-3-yl)a...) Show SMILES Nc1cccc(c1)-c1cnc2cnc(cn12)-c1cn[nH]c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of CHK1 by DELFIA				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50321665 (6-(1H-pyrazol-4-yl)-3-(pyridin-3-yl)imidazo[1,2-a]...) Show SMILES c1n[nH]cc1-c1cnc2ncc(-c3cccnc3)n2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of CHK1 by DELFIA				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50321671 (3-(6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-3-yl)b...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of CHK1 by DELFIA				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50321662 (6-(1H-indol-3-yl)-3-phenylimidazo[1,2-a]pyrazine \|...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of CHK1 by DELFIA				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50321666 (3-(4-phenoxyphenyl)-6-(1H-pyrazol-4-yl)imidazo[1,2...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of CHK1 by DELFIA				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50321664 (3-phenyl-6-(pyridin-3-yl)imidazo[1,2-a]pyrazine \| ...) Show SMILES c1nc2cnc(cn2c1-c1ccccc1)-c1cccnc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.39E+5	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of CHK1 by DELFIA				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50321660 (6-(1-benzyl-1H-pyrazol-4-yl)-3-phenylimidazo[1,2-a...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.08E+5	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of CHK1 by DELFIA				Bioorg Med Chem Lett 20: 4045-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.096 BindingDB Entry DOI: 10.7270/Q2MP5487
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%