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PubMed code 20621724

Compile data set for download or QSAR
Found 50 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM32203
PNG
(8-quinolinol | CHEMBL310555 | US10005735, Table 1....)
Show SMILES Oc1cccc2cccnc12
Show InChI InChI=1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H
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n/an/a 5.60E+3n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP2 expressed in baculovirus infected Sf9 cells

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50180733
PNG
(5-Methyl-2-pyridin-2-yl-1H-benzoimidazole | 5-meth...)
Show SMILES Cc1ccc2nc([nH]c2c1)-c1ccccn1
Show InChI InChI=1S/C13H11N3/c1-9-5-6-10-12(8-9)16-13(15-10)11-4-2-3-7-14-11/h2-8H,1H3,(H,15,16)
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n/an/a 7.70E+3n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP2 expressed in baculovirus infected Sf9 cells

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50180747
PNG
(2-pyridin-2-yl-1H-imidazo[4,5-c]pyridine | CHEMBL2...)
Show SMILES c1ccc(nc1)-c1nc2ccncc2[nH]1
Show InChI InChI=1S/C11H8N4/c1-2-5-13-9(3-1)11-14-8-4-6-12-7-10(8)15-11/h1-7H,(H,14,15)
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n/an/a 8.00E+3n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP2 expressed in baculovirus infected Sf9 cells

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Homo sapiens (Human))		BDBM50129661
PNG
(CHEMBL89671 | N-(thiazol-2-yl)picolinamide | Pyrid...)
Show SMILES O=C(Nc1nccs1)c1ccccn1
Show InChI InChI=1S/C9H7N3OS/c13-8(7-3-1-2-4-10-7)12-9-11-5-6-14-9/h1-6H,(H,11,12,13)
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n/an/a 8.10E+3n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP1

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM62926
PNG
(2-(2-pyridinyl)-3H-benzimidazol-5-amine | 2-Pyridi...)
Show SMILES Nc1ccc2nc([nH]c2c1)-c1ccccn1
Show InChI InChI=1S/C12H10N4/c13-8-4-5-9-11(7-8)16-12(15-9)10-3-1-2-6-14-10/h1-7H,13H2,(H,15,16)
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n/an/a 9.30E+3n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP2 expressed in baculovirus infected Sf9 cells

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50180749
PNG
(2-(thiazol-4-yl)-1H-benzo[d]imidazol-5-amine | 5-a...)
Show SMILES Nc1ccc2nc([nH]c2c1)-c1cscn1
Show InChI InChI=1S/C10H8N4S/c11-6-1-2-7-8(3-6)14-10(13-7)9-4-15-5-12-9/h1-5H,11H2,(H,13,14)
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n/an/a 1.01E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP2 expressed in baculovirus infected Sf9 cells

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Homo sapiens (Human))		BDBM50180747
PNG
(2-pyridin-2-yl-1H-imidazo[4,5-c]pyridine | CHEMBL2...)
Show SMILES c1ccc(nc1)-c1nc2ccncc2[nH]1
Show InChI InChI=1S/C11H8N4/c1-2-5-13-9(3-1)11-14-8-4-6-12-7-10(8)15-11/h1-7H,(H,14,15)
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n/an/a 1.03E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP1

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50078834
PNG
(2-(pyridin-2-yl)-1H-benzo[d]imidazole | 2-pyridin-...)
Show SMILES c1ccc(nc1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C12H9N3/c1-2-6-10-9(5-1)14-12(15-10)11-7-3-4-8-13-11/h1-8H,(H,14,15)
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n/an/a 1.33E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP2 expressed in baculovirus infected Sf9 cells

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50180735
PNG
(5-fluoro-2-(pyridin-2-yl)-1H-benzo[d]imidazole | 5...)
Show SMILES Fc1ccc2nc([nH]c2c1)-c1ccccn1
Show InChI InChI=1S/C12H8FN3/c13-8-4-5-9-11(7-8)16-12(15-9)10-3-1-2-6-14-10/h1-7H,(H,15,16)
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n/an/a 1.49E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP2 expressed in baculovirus infected Sf9 cells

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50180732
PNG
(5-Chloro-2-pyridin-2-yl-1H-benzoimidazole | 5-chlo...)
Show SMILES Clc1ccc2nc([nH]c2c1)-c1ccccn1
Show InChI InChI=1S/C12H8ClN3/c13-8-4-5-9-11(7-8)16-12(15-9)10-3-1-2-6-14-10/h1-7H,(H,15,16)
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n/an/a 1.81E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP2 expressed in baculovirus infected Sf9 cells

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Homo sapiens (Human))		BDBM50180745
PNG
(2-thiazol-4-yl-1H-imidazo[4,5-c]pyridine | 4-(1H-i...)
Show SMILES c1nc(cs1)-c1nc2ccncc2[nH]1
Show InChI InChI=1S/C9H6N4S/c1-2-10-3-7-6(1)12-9(13-7)8-4-14-5-11-8/h1-5H,(H,12,13)
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n/an/a 1.90E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP1

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Homo sapiens (Human))		BDBM32203
PNG
(8-quinolinol | CHEMBL310555 | US10005735, Table 1....)
Show SMILES Oc1cccc2cccnc12
Show InChI InChI=1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H
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n/an/a 2.15E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP1

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50180738
PNG
(1-methyl-2-thiazol-4-yl-1H-benzoimidazole | 4-(1-m...)
Show SMILES Cn1c(nc2ccccc12)-c1cscn1
Show InChI InChI=1S/C11H9N3S/c1-14-10-5-3-2-4-8(10)13-11(14)9-6-15-7-12-9/h2-7H,1H3
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n/an/a 2.43E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP2 expressed in baculovirus infected Sf9 cells

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50129661
PNG
(CHEMBL89671 | N-(thiazol-2-yl)picolinamide | Pyrid...)
Show SMILES O=C(Nc1nccs1)c1ccccn1
Show InChI InChI=1S/C9H7N3OS/c13-8(7-3-1-2-4-10-7)12-9-11-5-6-14-9/h1-6H,(H,11,12,13)
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n/an/a 2.58E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP2 expressed in baculovirus infected Sf9 cells

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50180731
PNG
(2-(pyridin-2-yl)-1H-imidazo[4,5-b]pyridine | 2-pyr...)
Show SMILES c1ccc(nc1)-c1nc2ncccc2[nH]1
Show InChI InChI=1S/C11H8N4/c1-2-6-12-8(4-1)11-14-9-5-3-7-13-10(9)15-11/h1-7H,(H,13,14,15)
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n/an/a 2.67E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP2 expressed in baculovirus infected Sf9 cells

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Homo sapiens (Human))		BDBM50180731
PNG
(2-(pyridin-2-yl)-1H-imidazo[4,5-b]pyridine | 2-pyr...)
Show SMILES c1ccc(nc1)-c1nc2ncccc2[nH]1
Show InChI InChI=1S/C11H8N4/c1-2-6-12-8(4-1)11-14-9-5-3-7-13-10(9)15-11/h1-7H,(H,13,14,15)
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n/an/a 2.76E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP1

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50180752
PNG
(4-(5-chloro-1H-benzo[d]imidazol-2-yl)thiazole | 5-...)
Show SMILES Clc1ccc2nc([nH]c2c1)-c1cscn1
Show InChI InChI=1S/C10H6ClN3S/c11-6-1-2-7-8(3-6)14-10(13-7)9-4-15-5-12-9/h1-5H,(H,13,14)
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n/an/a 2.80E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP2 expressed in baculovirus infected Sf9 cells

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50180737
PNG
(5,6-dimethyl-2-(pyridin-2-yl)-1H-benzo[d]imidazole...)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccccn1
Show InChI InChI=1S/C14H13N3/c1-9-7-12-13(8-10(9)2)17-14(16-12)11-5-3-4-6-15-11/h3-8H,1-2H3,(H,16,17)
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n/an/a 2.84E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP2 expressed in baculovirus infected Sf9 cells

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Homo sapiens (Human))		BDBM50078834
PNG
(2-(pyridin-2-yl)-1H-benzo[d]imidazole | 2-pyridin-...)
Show SMILES c1ccc(nc1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C12H9N3/c1-2-6-10-9(5-1)14-12(15-10)11-7-3-4-8-13-11/h1-8H,(H,14,15)
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n/an/a 2.84E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP1

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Homo sapiens (Human))		BDBM50180751
PNG
(5-nitro-2-(pyridin-2-yl)-1H-benzo[d]imidazole | 5-...)
Show SMILES [O-][N+](=O)c1ccc2nc([nH]c2c1)-c1ccccn1
Show InChI InChI=1S/C12H8N4O2/c17-16(18)8-4-5-9-11(7-8)15-12(14-9)10-3-1-2-6-13-10/h1-7H,(H,14,15)
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n/an/a 2.88E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP1

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Homo sapiens (Human))		BDBM50180738
PNG
(1-methyl-2-thiazol-4-yl-1H-benzoimidazole | 4-(1-m...)
Show SMILES Cn1c(nc2ccccc12)-c1cscn1
Show InChI InChI=1S/C11H9N3S/c1-14-10-5-3-2-4-8(10)13-11(14)9-6-15-7-12-9/h2-7H,1H3
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n/an/a 3.24E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP1

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Homo sapiens (Human))		BDBM50180733
PNG
(5-Methyl-2-pyridin-2-yl-1H-benzoimidazole | 5-meth...)
Show SMILES Cc1ccc2nc([nH]c2c1)-c1ccccn1
Show InChI InChI=1S/C13H11N3/c1-9-5-6-10-12(8-9)16-13(15-10)11-4-2-3-7-14-11/h2-8H,1H3,(H,15,16)
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n/an/a 3.26E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP1

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Homo sapiens (Human))		BDBM50180737
PNG
(5,6-dimethyl-2-(pyridin-2-yl)-1H-benzo[d]imidazole...)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccccn1
Show InChI InChI=1S/C14H13N3/c1-9-7-12-13(8-10(9)2)17-14(16-12)11-5-3-4-6-15-11/h3-8H,1-2H3,(H,16,17)
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n/an/a 3.26E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP1

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50180742
PNG
(2-(pyrazin-2-yl)-1H-benzo[d]imidazole | 2-pyrazin-...)
Show SMILES c1ccc2[nH]c(nc2c1)-c1cnccn1
Show InChI InChI=1S/C11H8N4/c1-2-4-9-8(3-1)14-11(15-9)10-7-12-5-6-13-10/h1-7H,(H,14,15)
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n/an/a 3.29E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP2 expressed in baculovirus infected Sf9 cells

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50180720
PNG
(2-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carbonitri...)
Show SMILES N#Cc1ccc2nc([nH]c2c1)-c1ccccn1
Show InChI InChI=1S/C13H8N4/c14-8-9-4-5-10-12(7-9)17-13(16-10)11-3-1-2-6-15-11/h1-7H,(H,16,17)
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n/an/a 3.29E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP2 expressed in baculovirus infected Sf9 cells

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Homo sapiens (Human))		BDBM50180746
PNG
(8-(pyridin-2-yl)-7H-purine | 8-pyridin-2-yl-7(9)H-...)
Show SMILES c1ccc(nc1)-c1nc2ncncc2[nH]1
Show InChI InChI=1S/C10H7N5/c1-2-4-12-7(3-1)10-14-8-5-11-6-13-9(8)15-10/h1-6H,(H,11,13,14,15)
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n/an/a 3.39E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP1

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Homo sapiens (Human))		BDBM50180735
PNG
(5-fluoro-2-(pyridin-2-yl)-1H-benzo[d]imidazole | 5...)
Show SMILES Fc1ccc2nc([nH]c2c1)-c1ccccn1
Show InChI InChI=1S/C12H8FN3/c13-8-4-5-9-11(7-8)16-12(15-9)10-3-1-2-6-14-10/h1-7H,(H,15,16)
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n/an/a 3.47E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP1

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50321647
PNG
(Benzoic acid-quinolin-8-yl-ester | CHEMBL1170610)
Show SMILES O=C(Oc1cccc2cccnc12)c1ccccc1
Show InChI InChI=1S/C16H11NO2/c18-16(13-6-2-1-3-7-13)19-14-10-4-8-12-9-5-11-17-15(12)14/h1-11H
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n/an/a 3.48E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP2 expressed in baculovirus infected Sf9 cells

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Homo sapiens (Human))		BDBM50180744
PNG
(4-(5-methyl-1H-benzo[d]imidazol-2-yl)thiazole | 5-...)
Show SMILES Cc1ccc2nc([nH]c2c1)-c1cscn1
Show InChI InChI=1S/C11H9N3S/c1-7-2-3-8-9(4-7)14-11(13-8)10-5-15-6-12-10/h2-6H,1H3,(H,13,14)
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n/an/a 3.55E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP1

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50180746
PNG
(8-(pyridin-2-yl)-7H-purine | 8-pyridin-2-yl-7(9)H-...)
Show SMILES c1ccc(nc1)-c1nc2ncncc2[nH]1
Show InChI InChI=1S/C10H7N5/c1-2-4-12-7(3-1)10-14-8-5-11-6-13-9(8)15-10/h1-6H,(H,11,13,14,15)
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n/an/a 3.64E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP2 expressed in baculovirus infected Sf9 cells

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Homo sapiens (Human))		BDBM50180720
PNG
(2-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carbonitri...)
Show SMILES N#Cc1ccc2nc([nH]c2c1)-c1ccccn1
Show InChI InChI=1S/C13H8N4/c14-8-9-4-5-10-12(7-9)17-13(16-10)11-3-1-2-6-15-11/h1-7H,(H,16,17)
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n/an/a 3.73E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP1

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50180721
PNG
(4-(5-fluoro-1H-benzo[d]imidazol-2-yl)thiazole | 5-...)
Show SMILES Fc1ccc2nc([nH]c2c1)-c1cscn1
Show InChI InChI=1S/C10H6FN3S/c11-6-1-2-7-8(3-6)14-10(13-7)9-4-15-5-12-9/h1-5H,(H,13,14)
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n/an/a 3.84E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP2 expressed in baculovirus infected Sf9 cells

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Homo sapiens (Human))		BDBM50180722
PNG
(4-(5,6-dimethyl-1H-benzo[d]imidazol-2-yl)thiazole ...)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1cscn1
Show InChI InChI=1S/C12H11N3S/c1-7-3-9-10(4-8(7)2)15-12(14-9)11-5-16-6-13-11/h3-6H,1-2H3,(H,14,15)
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n/an/a 3.88E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP1

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Homo sapiens (Human))		BDBM50321646
PNG
(2-(1H-imidazo[4,5-b]pyridin-2-yl)thiazole | CHEMBL...)
Show SMILES c1csc(n1)-c1nc2ncccc2[nH]1
Show InChI InChI=1S/C9H6N4S/c1-2-6-7(10-3-1)13-8(12-6)9-11-4-5-14-9/h1-5H,(H,10,12,13)
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n/an/a 3.98E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP1

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50227494
PNG
(CHEMBL257286 | N-(quinolin-8-yl)benzenesulfonamide...)
Show SMILES O=S(=O)(Nc1cccc2cccnc12)c1ccccc1
Show InChI InChI=1S/C15H12N2O2S/c18-20(19,13-8-2-1-3-9-13)17-14-10-4-6-12-7-5-11-16-15(12)14/h1-11,17H
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n/an/a 3.98E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP2 expressed in baculovirus infected Sf9 cells

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Homo sapiens (Human))		BDBM50180741
PNG
(2-(pyridin-2-yl)-1H-imidazo[4,5-b]pyrazine | 2-pyr...)
Show SMILES c1ccc(nc1)-c1nc2nccnc2[nH]1
Show InChI InChI=1S/C10H7N5/c1-2-4-11-7(3-1)8-14-9-10(15-8)13-6-5-12-9/h1-6H,(H,12,13,14,15)
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n/an/a 4.01E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP1

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50180744
PNG
(4-(5-methyl-1H-benzo[d]imidazol-2-yl)thiazole | 5-...)
Show SMILES Cc1ccc2nc([nH]c2c1)-c1cscn1
Show InChI InChI=1S/C11H9N3S/c1-7-2-3-8-9(4-7)14-11(13-8)10-5-15-6-12-10/h2-6H,1H3,(H,13,14)
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n/an/a 4.06E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP2 expressed in baculovirus infected Sf9 cells

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Homo sapiens (Human))		BDBM50180754
PNG
(CHEMBL199461 | phenyl(2-(thiazol-4-yl)-1H-benzo[d]...)
Show SMILES O=C(c1ccccc1)c1ccc2nc([nH]c2c1)-c1cscn1
Show InChI InChI=1S/C17H11N3OS/c21-16(11-4-2-1-3-5-11)12-6-7-13-14(8-12)20-17(19-13)15-9-22-10-18-15/h1-10H,(H,19,20)
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n/an/a 4.10E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP1

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Homo sapiens (Human))		BDBM50321648
PNG
(Benzenesulfonic acid quinolin-8-yl ester | CHEMBL1...)
Show SMILES O=S(=O)(Oc1cccc2cccnc12)c1ccccc1
Show InChI InChI=1S/C15H11NO3S/c17-20(18,13-8-2-1-3-9-13)19-14-10-4-6-12-7-5-11-16-15(12)14/h1-11H
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n/an/a 4.12E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP1

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50321648
PNG
(Benzenesulfonic acid quinolin-8-yl ester | CHEMBL1...)
Show SMILES O=S(=O)(Oc1cccc2cccnc12)c1ccccc1
Show InChI InChI=1S/C15H11NO3S/c17-20(18,13-8-2-1-3-9-13)19-14-10-4-6-12-7-5-11-16-15(12)14/h1-11H
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n/an/a 4.17E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP2 expressed in baculovirus infected Sf9 cells

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Homo sapiens (Human))		BDBM50321647
PNG
(Benzoic acid-quinolin-8-yl-ester | CHEMBL1170610)
Show SMILES O=C(Oc1cccc2cccnc12)c1ccccc1
Show InChI InChI=1S/C16H11NO2/c18-16(13-6-2-1-3-7-13)19-14-10-4-8-12-9-5-11-17-15(12)14/h1-11H
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n/an/a 4.28E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP1

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50180730
PNG
(5-tert-butyl-2-(pyridin-2-yl)-1H-benzo[d]imidazole...)
Show SMILES CC(C)(C)c1ccc2nc([nH]c2c1)-c1ccccn1
Show InChI InChI=1S/C16H17N3/c1-16(2,3)11-7-8-12-14(10-11)19-15(18-12)13-6-4-5-9-17-13/h4-10H,1-3H3,(H,18,19)
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n/an/a 4.41E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP2 expressed in baculovirus infected Sf9 cells

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50121347
PNG
(CHEMBL625 | THIABENDAZOLE)
Show SMILES c1nc(cs1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C10H7N3S/c1-2-4-8-7(3-1)12-10(13-8)9-5-14-6-11-9/h1-6H,(H,12,13)
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n/an/a 4.47E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP2 expressed in baculovirus infected Sf9 cells

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Homo sapiens (Human))		BDBM50227494
PNG
(CHEMBL257286 | N-(quinolin-8-yl)benzenesulfonamide...)
Show SMILES O=S(=O)(Nc1cccc2cccnc12)c1ccccc1
Show InChI InChI=1S/C15H12N2O2S/c18-20(19,13-8-2-1-3-9-13)17-14-10-4-6-12-7-5-11-16-15(12)14/h1-11,17H
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n/an/a 4.49E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP1

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Homo sapiens (Human))		BDBM50180721
PNG
(4-(5-fluoro-1H-benzo[d]imidazol-2-yl)thiazole | 5-...)
Show SMILES Fc1ccc2nc([nH]c2c1)-c1cscn1
Show InChI InChI=1S/C10H6FN3S/c11-6-1-2-7-8(3-6)14-10(13-7)9-4-15-5-12-9/h1-5H,(H,13,14)
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n/an/a 4.58E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP1

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Homo sapiens (Human))		BDBM50180752
PNG
(4-(5-chloro-1H-benzo[d]imidazol-2-yl)thiazole | 5-...)
Show SMILES Clc1ccc2nc([nH]c2c1)-c1cscn1
Show InChI InChI=1S/C10H6ClN3S/c11-6-1-2-7-8(3-6)14-10(13-7)9-4-15-5-12-9/h1-5H,(H,13,14)
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n/an/a 4.70E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP1

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Homo sapiens (Human))		BDBM50121347
PNG
(CHEMBL625 | THIABENDAZOLE)
Show SMILES c1nc(cs1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C10H7N3S/c1-2-4-8-7(3-1)12-10(13-8)9-5-14-6-11-9/h1-6H,(H,12,13)
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n/an/a 4.78E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP1

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50180741
PNG
(2-(pyridin-2-yl)-1H-imidazo[4,5-b]pyrazine | 2-pyr...)
Show SMILES c1ccc(nc1)-c1nc2nccnc2[nH]1
Show InChI InChI=1S/C10H7N5/c1-2-4-11-7(3-1)8-14-9-10(15-8)13-6-5-12-9/h1-6H,(H,12,13,14,15)
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n/an/a 4.84E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP2 expressed in baculovirus infected Sf9 cells

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Homo sapiens (Human))		BDBM50180736
PNG
(4-(5-nitro-1H-benzo[d]imidazol-2-yl)thiazole | 5-n...)
Show SMILES [O-][N+](=O)c1ccc2nc([nH]c2c1)-c1cscn1
Show InChI InChI=1S/C10H6N4O2S/c15-14(16)6-1-2-7-8(3-6)13-10(12-7)9-4-17-5-11-9/h1-5H,(H,12,13)
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n/an/a 4.85E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP1

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Homo sapiens (Human))		BDBM50180732
PNG
(5-Chloro-2-pyridin-2-yl-1H-benzoimidazole | 5-chlo...)
Show SMILES Clc1ccc2nc([nH]c2c1)-c1ccccn1
Show InChI InChI=1S/C12H8ClN3/c13-8-4-5-9-11(7-8)16-12(15-9)10-3-1-2-6-14-10/h1-7H,(H,15,16)
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n/an/a 4.88E+4n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP1

Bioorg Med Chem Lett 20: 4038-44 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.093
BindingDB Entry DOI: 10.7270/Q2RF5W0K
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%