Found 40 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50346238
((5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-...)Show SMILES Oc1ccccc1C1CC(=NN1C(=O)c1cccs1)c1cccnc1 |c:10| Show InChI InChI=1S/C19H15N3O2S/c23-17-7-2-1-6-14(17)16-11-15(13-5-3-9-20-12-13)21-22(16)19(24)18-8-4-10-25-18/h1-10,12,16,23H,11H2 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of KIT2 |
Bioorg Med Chem Lett 20: 4795-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.110
BindingDB Entry DOI: 10.7270/Q2WH2QBS |
More data for this
Ligand-Target Pair | |
RAC-beta serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50346238
((5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-...)Show SMILES Oc1ccccc1C1CC(=NN1C(=O)c1cccs1)c1cccnc1 |c:10| Show InChI InChI=1S/C19H15N3O2S/c23-17-7-2-1-6-14(17)16-11-15(13-5-3-9-20-12-13)21-22(16)19(24)18-8-4-10-25-18/h1-10,12,16,23H,11H2 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of AKT2 |
Bioorg Med Chem Lett 20: 4795-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.110
BindingDB Entry DOI: 10.7270/Q2WH2QBS |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50346240
((7-ethoxybenzofuran-2-yl)(5-(2-hydroxyphenyl)-3-(p...)Show SMILES CCOc1cccc2cc(oc12)C(=O)N1N=C(CC1c1ccccc1O)c1cccnc1 |c:17| Show InChI InChI=1S/C25H21N3O4/c1-2-31-22-11-5-7-16-13-23(32-24(16)22)25(30)28-20(18-9-3-4-10-21(18)29)14-19(27-28)17-8-6-12-26-15-17/h3-13,15,20,29H,2,14H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of FGFR1 |
Bioorg Med Chem Lett 20: 4795-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.110
BindingDB Entry DOI: 10.7270/Q2WH2QBS |
More data for this
Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM50346241
((5-bromofuran-2-yl)(5-(2-hydroxyphenyl)-3-(pyridin...)Show SMILES Oc1ccccc1C1CC(=NN1C(=O)c1ccc(Br)o1)c1cccnc1 |c:10| Show InChI InChI=1S/C19H14BrN3O3/c20-18-8-7-17(26-18)19(25)23-15(13-5-1-2-6-16(13)24)10-14(22-23)12-4-3-9-21-11-12/h1-9,11,15,24H,10H2 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CSF1R |
Bioorg Med Chem Lett 20: 4795-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.110
BindingDB Entry DOI: 10.7270/Q2WH2QBS |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50346242
((3-(1H-pyrazol-1-yl)phenyl)(5-(2-hydroxyphenyl)-3-...)Show SMILES Oc1ccccc1C1CC(=NN1C(=O)c1cccc(c1)-n1cccn1)c1cccnc1 |c:10| Show InChI InChI=1S/C24H19N5O2/c30-23-10-2-1-9-20(23)22-15-21(18-7-4-11-25-16-18)27-29(22)24(31)17-6-3-8-19(14-17)28-13-5-12-26-28/h1-14,16,22,30H,15H2 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 20: 4795-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.110
BindingDB Entry DOI: 10.7270/Q2WH2QBS |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50346243
(CHEMBL1779593 | furan-2-yl(5-(2-hydroxyphenyl)-3-(...)Show SMILES Oc1ccccc1C1CC(=NN1C(=O)c1ccco1)c1cccnc1 |c:10| Show InChI InChI=1S/C19H15N3O3/c23-17-7-2-1-6-14(17)16-11-15(13-5-3-9-20-12-13)21-22(16)19(24)18-8-4-10-25-18/h1-10,12,16,23H,11H2 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 20: 4795-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.110
BindingDB Entry DOI: 10.7270/Q2WH2QBS |
More data for this
Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM50346243
(CHEMBL1779593 | furan-2-yl(5-(2-hydroxyphenyl)-3-(...)Show SMILES Oc1ccccc1C1CC(=NN1C(=O)c1ccco1)c1cccnc1 |c:10| Show InChI InChI=1S/C19H15N3O3/c23-17-7-2-1-6-14(17)16-11-15(13-5-3-9-20-12-13)21-22(16)19(24)18-8-4-10-25-18/h1-10,12,16,23H,11H2 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
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| Purchase
CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CSF1R |
Bioorg Med Chem Lett 20: 4795-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.110
BindingDB Entry DOI: 10.7270/Q2WH2QBS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50346243
(CHEMBL1779593 | furan-2-yl(5-(2-hydroxyphenyl)-3-(...)Show SMILES Oc1ccccc1C1CC(=NN1C(=O)c1ccco1)c1cccnc1 |c:10| Show InChI InChI=1S/C19H15N3O3/c23-17-7-2-1-6-14(17)16-11-15(13-5-3-9-20-12-13)21-22(16)19(24)18-8-4-10-25-18/h1-10,12,16,23H,11H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Chk2 |
Bioorg Med Chem Lett 20: 4795-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.110
BindingDB Entry DOI: 10.7270/Q2WH2QBS |
More data for this
Ligand-Target Pair | |
RAC-beta serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50346242
((3-(1H-pyrazol-1-yl)phenyl)(5-(2-hydroxyphenyl)-3-...)Show SMILES Oc1ccccc1C1CC(=NN1C(=O)c1cccc(c1)-n1cccn1)c1cccnc1 |c:10| Show InChI InChI=1S/C24H19N5O2/c30-23-10-2-1-9-20(23)22-15-21(18-7-4-11-25-16-18)27-29(22)24(31)17-6-3-8-19(14-17)28-13-5-12-26-28/h1-14,16,22,30H,15H2 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of AKT2 |
Bioorg Med Chem Lett 20: 4795-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.110
BindingDB Entry DOI: 10.7270/Q2WH2QBS |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50346239
((5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-...)Show SMILES Oc1ccccc1C1CC(=NN1C(=O)c1ccc[nH]1)c1cccnc1 |c:10| Show InChI InChI=1S/C19H16N4O2/c24-18-8-2-1-6-14(18)17-11-16(13-5-3-9-20-12-13)22-23(17)19(25)15-7-4-10-21-15/h1-10,12,17,21,24H,11H2 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 20: 4795-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.110
BindingDB Entry DOI: 10.7270/Q2WH2QBS |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50346243
(CHEMBL1779593 | furan-2-yl(5-(2-hydroxyphenyl)-3-(...)Show SMILES Oc1ccccc1C1CC(=NN1C(=O)c1ccco1)c1cccnc1 |c:10| Show InChI InChI=1S/C19H15N3O3/c23-17-7-2-1-6-14(17)16-11-15(13-5-3-9-20-12-13)21-22(16)19(24)18-8-4-10-25-18/h1-10,12,16,23H,11H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of FGFR1 |
Bioorg Med Chem Lett 20: 4795-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.110
BindingDB Entry DOI: 10.7270/Q2WH2QBS |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50346242
((3-(1H-pyrazol-1-yl)phenyl)(5-(2-hydroxyphenyl)-3-...)Show SMILES Oc1ccccc1C1CC(=NN1C(=O)c1cccc(c1)-n1cccn1)c1cccnc1 |c:10| Show InChI InChI=1S/C24H19N5O2/c30-23-10-2-1-9-20(23)22-15-21(18-7-4-11-25-16-18)27-29(22)24(31)17-6-3-8-19(14-17)28-13-5-12-26-28/h1-14,16,22,30H,15H2 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of KIT2 |
Bioorg Med Chem Lett 20: 4795-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.110
BindingDB Entry DOI: 10.7270/Q2WH2QBS |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50346239
((5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-...)Show SMILES Oc1ccccc1C1CC(=NN1C(=O)c1ccc[nH]1)c1cccnc1 |c:10| Show InChI InChI=1S/C19H16N4O2/c24-18-8-2-1-6-14(18)17-11-16(13-5-3-9-20-12-13)22-23(17)19(25)15-7-4-10-21-15/h1-10,12,17,21,24H,11H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of KDR |
Bioorg Med Chem Lett 20: 4795-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.110
BindingDB Entry DOI: 10.7270/Q2WH2QBS |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50346240
((7-ethoxybenzofuran-2-yl)(5-(2-hydroxyphenyl)-3-(p...)Show SMILES CCOc1cccc2cc(oc12)C(=O)N1N=C(CC1c1ccccc1O)c1cccnc1 |c:17| Show InChI InChI=1S/C25H21N3O4/c1-2-31-22-11-5-7-16-13-23(32-24(16)22)25(30)28-20(18-9-3-4-10-21(18)29)14-19(27-28)17-8-6-12-26-15-17/h3-13,15,20,29H,2,14H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of KDR |
Bioorg Med Chem Lett 20: 4795-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.110
BindingDB Entry DOI: 10.7270/Q2WH2QBS |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50346241
((5-bromofuran-2-yl)(5-(2-hydroxyphenyl)-3-(pyridin...)Show SMILES Oc1ccccc1C1CC(=NN1C(=O)c1ccc(Br)o1)c1cccnc1 |c:10| Show InChI InChI=1S/C19H14BrN3O3/c20-18-8-7-17(26-18)19(25)23-15(13-5-1-2-6-16(13)24)10-14(22-23)12-4-3-9-21-11-12/h1-9,11,15,24H,10H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of FGFR1 |
Bioorg Med Chem Lett 20: 4795-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.110
BindingDB Entry DOI: 10.7270/Q2WH2QBS |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50346242
((3-(1H-pyrazol-1-yl)phenyl)(5-(2-hydroxyphenyl)-3-...)Show SMILES Oc1ccccc1C1CC(=NN1C(=O)c1cccc(c1)-n1cccn1)c1cccnc1 |c:10| Show InChI InChI=1S/C24H19N5O2/c30-23-10-2-1-9-20(23)22-15-21(18-7-4-11-25-16-18)27-29(22)24(31)17-6-3-8-19(14-17)28-13-5-12-26-28/h1-14,16,22,30H,15H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of FGFR1 |
Bioorg Med Chem Lett 20: 4795-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.110
BindingDB Entry DOI: 10.7270/Q2WH2QBS |
More data for this
Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM50346238
((5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-...)Show SMILES Oc1ccccc1C1CC(=NN1C(=O)c1cccs1)c1cccnc1 |c:10| Show InChI InChI=1S/C19H15N3O2S/c23-17-7-2-1-6-14(17)16-11-15(13-5-3-9-20-12-13)21-22(16)19(24)18-8-4-10-25-18/h1-10,12,16,23H,11H2 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CSF1R |
Bioorg Med Chem Lett 20: 4795-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.110
BindingDB Entry DOI: 10.7270/Q2WH2QBS |
More data for this
Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM50346239
((5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-...)Show SMILES Oc1ccccc1C1CC(=NN1C(=O)c1ccc[nH]1)c1cccnc1 |c:10| Show InChI InChI=1S/C19H16N4O2/c24-18-8-2-1-6-14(18)17-11-16(13-5-3-9-20-12-13)22-23(17)19(25)15-7-4-10-21-15/h1-10,12,17,21,24H,11H2 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CSF1R |
Bioorg Med Chem Lett 20: 4795-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.110
BindingDB Entry DOI: 10.7270/Q2WH2QBS |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50346240
((7-ethoxybenzofuran-2-yl)(5-(2-hydroxyphenyl)-3-(p...)Show SMILES CCOc1cccc2cc(oc12)C(=O)N1N=C(CC1c1ccccc1O)c1cccnc1 |c:17| Show InChI InChI=1S/C25H21N3O4/c1-2-31-22-11-5-7-16-13-23(32-24(16)22)25(30)28-20(18-9-3-4-10-21(18)29)14-19(27-28)17-8-6-12-26-15-17/h3-13,15,20,29H,2,14H2,1H3 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 20: 4795-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.110
BindingDB Entry DOI: 10.7270/Q2WH2QBS |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (Human)) | BDBM50346243
(CHEMBL1779593 | furan-2-yl(5-(2-hydroxyphenyl)-3-(...)Show SMILES Oc1ccccc1C1CC(=NN1C(=O)c1ccco1)c1cccnc1 |c:10| Show InChI InChI=1S/C19H15N3O3/c23-17-7-2-1-6-14(17)16-11-15(13-5-3-9-20-12-13)21-22(16)19(24)18-8-4-10-25-18/h1-10,12,16,23H,11H2 | PDB
Reactome pathway
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CDK1 |
Bioorg Med Chem Lett 20: 4795-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.110
BindingDB Entry DOI: 10.7270/Q2WH2QBS |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50346239
((5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-...)Show SMILES Oc1ccccc1C1CC(=NN1C(=O)c1ccc[nH]1)c1cccnc1 |c:10| Show InChI InChI=1S/C19H16N4O2/c24-18-8-2-1-6-14(18)17-11-16(13-5-3-9-20-12-13)22-23(17)19(25)15-7-4-10-21-15/h1-10,12,17,21,24H,11H2 | PDB
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| CHEMBL
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UniChem
| Article
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of KIT2 |
Bioorg Med Chem Lett 20: 4795-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.110
BindingDB Entry DOI: 10.7270/Q2WH2QBS |
More data for this
Ligand-Target Pair | |
RAC-beta serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50346241
((5-bromofuran-2-yl)(5-(2-hydroxyphenyl)-3-(pyridin...)Show SMILES Oc1ccccc1C1CC(=NN1C(=O)c1ccc(Br)o1)c1cccnc1 |c:10| Show InChI InChI=1S/C19H14BrN3O3/c20-18-8-7-17(26-18)19(25)23-15(13-5-1-2-6-16(13)24)10-14(22-23)12-4-3-9-21-11-12/h1-9,11,15,24H,10H2 | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of AKT2 |
Bioorg Med Chem Lett 20: 4795-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.110
BindingDB Entry DOI: 10.7270/Q2WH2QBS |
More data for this
Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM50346240
((7-ethoxybenzofuran-2-yl)(5-(2-hydroxyphenyl)-3-(p...)Show SMILES CCOc1cccc2cc(oc12)C(=O)N1N=C(CC1c1ccccc1O)c1cccnc1 |c:17| Show InChI InChI=1S/C25H21N3O4/c1-2-31-22-11-5-7-16-13-23(32-24(16)22)25(30)28-20(18-9-3-4-10-21(18)29)14-19(27-28)17-8-6-12-26-15-17/h3-13,15,20,29H,2,14H2,1H3 | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CSF1R |
Bioorg Med Chem Lett 20: 4795-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.110
BindingDB Entry DOI: 10.7270/Q2WH2QBS |
More data for this
Ligand-Target Pair | |
RAC-beta serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50346239
((5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-...)Show SMILES Oc1ccccc1C1CC(=NN1C(=O)c1ccc[nH]1)c1cccnc1 |c:10| Show InChI InChI=1S/C19H16N4O2/c24-18-8-2-1-6-14(18)17-11-16(13-5-3-9-20-12-13)22-23(17)19(25)15-7-4-10-21-15/h1-10,12,17,21,24H,11H2 | PDB
UniProtKB/SwissProt
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of AKT2 |
Bioorg Med Chem Lett 20: 4795-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.110
BindingDB Entry DOI: 10.7270/Q2WH2QBS |
More data for this
Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM50346242
((3-(1H-pyrazol-1-yl)phenyl)(5-(2-hydroxyphenyl)-3-...)Show SMILES Oc1ccccc1C1CC(=NN1C(=O)c1cccc(c1)-n1cccn1)c1cccnc1 |c:10| Show InChI InChI=1S/C24H19N5O2/c30-23-10-2-1-9-20(23)22-15-21(18-7-4-11-25-16-18)27-29(22)24(31)17-6-3-8-19(14-17)28-13-5-12-26-28/h1-14,16,22,30H,15H2 | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CSF1R |
Bioorg Med Chem Lett 20: 4795-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.110
BindingDB Entry DOI: 10.7270/Q2WH2QBS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase ICK
(Homo sapiens (Human)) | BDBM50346243
(CHEMBL1779593 | furan-2-yl(5-(2-hydroxyphenyl)-3-(...)Show SMILES Oc1ccccc1C1CC(=NN1C(=O)c1ccco1)c1cccnc1 |c:10| Show InChI InChI=1S/C19H15N3O3/c23-17-7-2-1-6-14(17)16-11-15(13-5-3-9-20-12-13)21-22(16)19(24)18-8-4-10-25-18/h1-10,12,16,23H,11H2 | KEGG
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of LCK2 |
Bioorg Med Chem Lett 20: 4795-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.110
BindingDB Entry DOI: 10.7270/Q2WH2QBS |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50346241
((5-bromofuran-2-yl)(5-(2-hydroxyphenyl)-3-(pyridin...)Show SMILES Oc1ccccc1C1CC(=NN1C(=O)c1ccc(Br)o1)c1cccnc1 |c:10| Show InChI InChI=1S/C19H14BrN3O3/c20-18-8-7-17(26-18)19(25)23-15(13-5-1-2-6-16(13)24)10-14(22-23)12-4-3-9-21-11-12/h1-9,11,15,24H,10H2 | PDB
MMDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of KDR |
Bioorg Med Chem Lett 20: 4795-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.110
BindingDB Entry DOI: 10.7270/Q2WH2QBS |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50346238
((5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-...)Show SMILES Oc1ccccc1C1CC(=NN1C(=O)c1cccs1)c1cccnc1 |c:10| Show InChI InChI=1S/C19H15N3O2S/c23-17-7-2-1-6-14(17)16-11-15(13-5-3-9-20-12-13)21-22(16)19(24)18-8-4-10-25-18/h1-10,12,16,23H,11H2 | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 20: 4795-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.110
BindingDB Entry DOI: 10.7270/Q2WH2QBS |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50346243
(CHEMBL1779593 | furan-2-yl(5-(2-hydroxyphenyl)-3-(...)Show SMILES Oc1ccccc1C1CC(=NN1C(=O)c1ccco1)c1cccnc1 |c:10| Show InChI InChI=1S/C19H15N3O3/c23-17-7-2-1-6-14(17)16-11-15(13-5-3-9-20-12-13)21-22(16)19(24)18-8-4-10-25-18/h1-10,12,16,23H,11H2 | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of KIT2 |
Bioorg Med Chem Lett 20: 4795-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.110
BindingDB Entry DOI: 10.7270/Q2WH2QBS |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50346243
(CHEMBL1779593 | furan-2-yl(5-(2-hydroxyphenyl)-3-(...)Show SMILES Oc1ccccc1C1CC(=NN1C(=O)c1ccco1)c1cccnc1 |c:10| Show InChI InChI=1S/C19H15N3O3/c23-17-7-2-1-6-14(17)16-11-15(13-5-3-9-20-12-13)21-22(16)19(24)18-8-4-10-25-18/h1-10,12,16,23H,11H2 | PDB
MMDB
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Reactome pathway
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 |
Bioorg Med Chem Lett 20: 4795-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.110
BindingDB Entry DOI: 10.7270/Q2WH2QBS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Chk1
(Homo sapiens (Human)) | BDBM50346243
(CHEMBL1779593 | furan-2-yl(5-(2-hydroxyphenyl)-3-(...)Show SMILES Oc1ccccc1C1CC(=NN1C(=O)c1ccco1)c1cccnc1 |c:10| Show InChI InChI=1S/C19H15N3O3/c23-17-7-2-1-6-14(17)16-11-15(13-5-3-9-20-12-13)21-22(16)19(24)18-8-4-10-25-18/h1-10,12,16,23H,11H2 | PDB
MMDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Chk1 |
Bioorg Med Chem Lett 20: 4795-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.110
BindingDB Entry DOI: 10.7270/Q2WH2QBS |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50346240
((7-ethoxybenzofuran-2-yl)(5-(2-hydroxyphenyl)-3-(p...)Show SMILES CCOc1cccc2cc(oc12)C(=O)N1N=C(CC1c1ccccc1O)c1cccnc1 |c:17| Show InChI InChI=1S/C25H21N3O4/c1-2-31-22-11-5-7-16-13-23(32-24(16)22)25(30)28-20(18-9-3-4-10-21(18)29)14-19(27-28)17-8-6-12-26-15-17/h3-13,15,20,29H,2,14H2,1H3 | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of KIT2 |
Bioorg Med Chem Lett 20: 4795-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.110
BindingDB Entry DOI: 10.7270/Q2WH2QBS |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50346238
((5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-...)Show SMILES Oc1ccccc1C1CC(=NN1C(=O)c1cccs1)c1cccnc1 |c:10| Show InChI InChI=1S/C19H15N3O2S/c23-17-7-2-1-6-14(17)16-11-15(13-5-3-9-20-12-13)21-22(16)19(24)18-8-4-10-25-18/h1-10,12,16,23H,11H2 | PDB
MMDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of KDR |
Bioorg Med Chem Lett 20: 4795-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.110
BindingDB Entry DOI: 10.7270/Q2WH2QBS |
More data for this
Ligand-Target Pair | |
RAC-beta serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50346240
((7-ethoxybenzofuran-2-yl)(5-(2-hydroxyphenyl)-3-(p...)Show SMILES CCOc1cccc2cc(oc12)C(=O)N1N=C(CC1c1ccccc1O)c1cccnc1 |c:17| Show InChI InChI=1S/C25H21N3O4/c1-2-31-22-11-5-7-16-13-23(32-24(16)22)25(30)28-20(18-9-3-4-10-21(18)29)14-19(27-28)17-8-6-12-26-15-17/h3-13,15,20,29H,2,14H2,1H3 | PDB
UniProtKB/SwissProt
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UniChem
Similars
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of AKT2 |
Bioorg Med Chem Lett 20: 4795-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.110
BindingDB Entry DOI: 10.7270/Q2WH2QBS |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50346241
((5-bromofuran-2-yl)(5-(2-hydroxyphenyl)-3-(pyridin...)Show SMILES Oc1ccccc1C1CC(=NN1C(=O)c1ccc(Br)o1)c1cccnc1 |c:10| Show InChI InChI=1S/C19H14BrN3O3/c20-18-8-7-17(26-18)19(25)23-15(13-5-1-2-6-16(13)24)10-14(22-23)12-4-3-9-21-11-12/h1-9,11,15,24H,10H2 | PDB
NCI pathway
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UniChem
Similars
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 |
Bioorg Med Chem Lett 20: 4795-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.110
BindingDB Entry DOI: 10.7270/Q2WH2QBS |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50346243
(CHEMBL1779593 | furan-2-yl(5-(2-hydroxyphenyl)-3-(...)Show SMILES Oc1ccccc1C1CC(=NN1C(=O)c1ccco1)c1cccnc1 |c:10| Show InChI InChI=1S/C19H15N3O3/c23-17-7-2-1-6-14(17)16-11-15(13-5-3-9-20-12-13)21-22(16)19(24)18-8-4-10-25-18/h1-10,12,16,23H,11H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of KDR |
Bioorg Med Chem Lett 20: 4795-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.110
BindingDB Entry DOI: 10.7270/Q2WH2QBS |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50346242
((3-(1H-pyrazol-1-yl)phenyl)(5-(2-hydroxyphenyl)-3-...)Show SMILES Oc1ccccc1C1CC(=NN1C(=O)c1cccc(c1)-n1cccn1)c1cccnc1 |c:10| Show InChI InChI=1S/C24H19N5O2/c30-23-10-2-1-9-20(23)22-15-21(18-7-4-11-25-16-18)27-29(22)24(31)17-6-3-8-19(14-17)28-13-5-12-26-28/h1-14,16,22,30H,15H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of KDR |
Bioorg Med Chem Lett 20: 4795-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.110
BindingDB Entry DOI: 10.7270/Q2WH2QBS |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50346238
((5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-...)Show SMILES Oc1ccccc1C1CC(=NN1C(=O)c1cccs1)c1cccnc1 |c:10| Show InChI InChI=1S/C19H15N3O2S/c23-17-7-2-1-6-14(17)16-11-15(13-5-3-9-20-12-13)21-22(16)19(24)18-8-4-10-25-18/h1-10,12,16,23H,11H2 | PDB
MMDB
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Reactome pathway
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of FGFR1 |
Bioorg Med Chem Lett 20: 4795-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.110
BindingDB Entry DOI: 10.7270/Q2WH2QBS |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50346239
((5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-...)Show SMILES Oc1ccccc1C1CC(=NN1C(=O)c1ccc[nH]1)c1cccnc1 |c:10| Show InChI InChI=1S/C19H16N4O2/c24-18-8-2-1-6-14(18)17-11-16(13-5-3-9-20-12-13)22-23(17)19(25)15-7-4-10-21-15/h1-10,12,17,21,24H,11H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
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| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of FGFR1 |
Bioorg Med Chem Lett 20: 4795-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.110
BindingDB Entry DOI: 10.7270/Q2WH2QBS |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50346241
((5-bromofuran-2-yl)(5-(2-hydroxyphenyl)-3-(pyridin...)Show SMILES Oc1ccccc1C1CC(=NN1C(=O)c1ccc(Br)o1)c1cccnc1 |c:10| Show InChI InChI=1S/C19H14BrN3O3/c20-18-8-7-17(26-18)19(25)23-15(13-5-1-2-6-16(13)24)10-14(22-23)12-4-3-9-21-11-12/h1-9,11,15,24H,10H2 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Inhibition of KIT2 |
Bioorg Med Chem Lett 20: 4795-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.110
BindingDB Entry DOI: 10.7270/Q2WH2QBS |
More data for this
Ligand-Target Pair | |
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