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PubMed code 2066986

Compile data set for download or QSAR
Found 137 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic acetylcholine receptor M1


(RAT)
BDBM82376
PNG
(CAS_80880-90-6 | NSC_5387 | TELENZEPINE)
Show SMILES CN1CCN(CC(=O)N2c3c(C)scc3C(=O)Nc3ccccc23)CC1
Show InChI InChI=1S/C19H22N4O2S/c1-13-18-14(12-26-13)19(25)20-15-5-3-4-6-16(15)23(18)17(24)11-22-9-7-21(2)8-10-22/h3-6,12H,7-11H2,1-2H3,(H,20,25)
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1.80n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M1 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012344
PNG
(11-{2-[4-(10-Diethylamino-decyl)-piperazin-1-yl]-a...)
Show SMILES CCN(CC)CCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C32H48N6O2/c1-3-35(4-2)20-13-9-7-5-6-8-10-14-21-36-22-24-37(25-23-36)26-30(39)38-29-18-12-11-16-27(29)32(40)34-28-17-15-19-33-31(28)38/h11-12,15-19H,3-10,13-14,20-26H2,1-2H3,(H,34,40)
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3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-Methyl-scopolamine to Muscarinic acetylcholine receptor M1 of transfected A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012336
PNG
(11-(2-{4-[10-(2-Methoxy-benzylamino)-decyl]-pipera...)
Show SMILES COc1ccccc1CNCCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C36H48N6O3/c1-45-33-19-11-8-15-29(33)27-37-20-12-6-4-2-3-5-7-13-22-40-23-25-41(26-24-40)28-34(43)42-32-18-10-9-16-30(32)36(44)39-31-17-14-21-38-35(31)42/h8-11,14-19,21,37H,2-7,12-13,20,22-28H2,1H3,(H,39,44)
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3.30n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-Methyl-scopolamine to Muscarinic acetylcholine receptor M1 of transfected A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM82376
PNG
(CAS_80880-90-6 | NSC_5387 | TELENZEPINE)
Show SMILES CN1CCN(CC(=O)N2c3c(C)scc3C(=O)Nc3ccccc23)CC1
Show InChI InChI=1S/C19H22N4O2S/c1-13-18-14(12-26-13)19(25)20-15-5-3-4-6-16(15)23(18)17(24)11-22-9-7-21(2)8-10-22/h3-6,12H,7-11H2,1-2H3,(H,20,25)
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6.90n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M3 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50012353
PNG
(11-{2-[4-(10-Amino-decyl)-piperazin-1-yl]-acetyl}-...)
Show SMILES NCCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C28H40N6O2/c29-15-9-5-3-1-2-4-6-10-17-32-18-20-33(21-19-32)22-26(35)34-25-14-8-7-12-23(25)28(36)31-24-13-11-16-30-27(24)34/h7-8,11-14,16H,1-6,9-10,15,17-22,29H2,(H,31,36)
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12n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50012344
PNG
(11-{2-[4-(10-Diethylamino-decyl)-piperazin-1-yl]-a...)
Show SMILES CCN(CC)CCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C32H48N6O2/c1-3-35(4-2)20-13-9-7-5-6-8-10-14-21-36-22-24-37(25-23-36)26-30(39)38-29-18-12-11-16-27(29)32(40)34-28-17-15-19-33-31(28)38/h11-12,15-19H,3-10,13-14,20-26H2,1-2H3,(H,34,40)
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14n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012353
PNG
(11-{2-[4-(10-Amino-decyl)-piperazin-1-yl]-acetyl}-...)
Show SMILES NCCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C28H40N6O2/c29-15-9-5-3-1-2-4-6-10-17-32-18-20-33(21-19-32)22-26(35)34-25-14-8-7-12-23(25)28(36)31-24-13-11-16-30-27(24)34/h7-8,11-14,16H,1-6,9-10,15,17-22,29H2,(H,31,36)
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16n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-Methyl-scopolamine to Muscarinic acetylcholine receptor M1 of transfected A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(RAT)
BDBM82376
PNG
(CAS_80880-90-6 | NSC_5387 | TELENZEPINE)
Show SMILES CN1CCN(CC(=O)N2c3c(C)scc3C(=O)Nc3ccccc23)CC1
Show InChI InChI=1S/C19H22N4O2S/c1-13-18-14(12-26-13)19(25)20-15-5-3-4-6-16(15)23(18)17(24)11-22-9-7-21(2)8-10-22/h3-6,12H,7-11H2,1-2H3,(H,20,25)
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17n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-Methyl-scopolamine to muscarinic acetylcholine receptor M4 of rat heart NG108-15 cells


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50012348
PNG
(2-(6-{4-[2-Oxo-2-(6-oxo-5,6-dihydro-benzo[e]pyrido...)
Show SMILES O=C(CN1CCN(CCCCCCN2C(=O)c3ccccc3C2=O)CC1)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C32H34N6O4/c39-28(38-27-14-6-5-12-25(27)30(40)34-26-13-9-15-33-29(26)38)22-36-20-18-35(19-21-36)16-7-1-2-8-17-37-31(41)23-10-3-4-11-24(23)32(37)42/h3-6,9-15H,1-2,7-8,16-22H2,(H,34,40)
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18n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012348
PNG
(2-(6-{4-[2-Oxo-2-(6-oxo-5,6-dihydro-benzo[e]pyrido...)
Show SMILES O=C(CN1CCN(CCCCCCN2C(=O)c3ccccc3C2=O)CC1)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C32H34N6O4/c39-28(38-27-14-6-5-12-25(27)30(40)34-26-13-9-15-33-29(26)38)22-36-20-18-35(19-21-36)16-7-1-2-8-17-37-31(41)23-10-3-4-11-24(23)32(37)42/h3-6,9-15H,1-2,7-8,16-22H2,(H,34,40)
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18n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-Methyl-scopolamine to Muscarinic acetylcholine receptor M1 of transfected A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50012357
PNG
(2-(5-{4-[2-Oxo-2-(6-oxo-5,6-dihydro-benzo[e]pyrido...)
Show SMILES O=C(CN1CCN(CCCCCN2C(=O)c3ccccc3C2=O)CC1)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C31H32N6O4/c38-27(37-26-13-5-4-11-24(26)29(39)33-25-12-8-14-32-28(25)37)21-35-19-17-34(18-20-35)15-6-1-7-16-36-30(40)22-9-2-3-10-23(22)31(36)41/h2-5,8-14H,1,6-7,15-21H2,(H,33,39)
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20n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012360
PNG
(11-{2-[4-(8-Amino-octyl)-piperazin-1-yl]-acetyl}-5...)
Show SMILES NCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C26H36N6O2/c27-13-7-3-1-2-4-8-15-30-16-18-31(19-17-30)20-24(33)32-23-12-6-5-10-21(23)26(34)29-22-11-9-14-28-25(22)32/h5-6,9-12,14H,1-4,7-8,13,15-20,27H2,(H,29,34)
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20n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-Methyl-scopolamine to Muscarinic acetylcholine receptor M1 of transfected A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50012338
PNG
((6-{4-[2-Oxo-2-(6-oxo-5,6-dihydro-benzo[e]pyrido[3...)
Show SMILES CC(C)(C)OC(=O)NCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C29H40N6O4/c1-29(2,3)39-28(38)31-14-8-4-5-9-16-33-17-19-34(20-18-33)21-25(36)35-24-13-7-6-11-22(24)27(37)32-23-12-10-15-30-26(23)35/h6-7,10-13,15H,4-5,8-9,14,16-21H2,1-3H3,(H,31,38)(H,32,37)
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21n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50012336
PNG
(11-(2-{4-[10-(2-Methoxy-benzylamino)-decyl]-pipera...)
Show SMILES COc1ccccc1CNCCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C36H48N6O3/c1-45-33-19-11-8-15-29(33)27-37-20-12-6-4-2-3-5-7-13-22-40-23-25-41(26-24-40)28-34(43)42-32-18-10-9-16-30(32)36(44)39-31-17-14-21-38-35(31)42/h8-11,14-19,21,37H,2-7,12-13,20,22-28H2,1H3,(H,39,44)
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22n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(RAT)
BDBM50012338
PNG
((6-{4-[2-Oxo-2-(6-oxo-5,6-dihydro-benzo[e]pyrido[3...)
Show SMILES CC(C)(C)OC(=O)NCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C29H40N6O4/c1-29(2,3)39-28(38)31-14-8-4-5-9-16-33-17-19-34(20-18-33)21-25(36)35-24-13-7-6-11-22(24)27(37)32-23-12-10-15-30-26(23)35/h6-7,10-13,15H,4-5,8-9,14,16-21H2,1-3H3,(H,31,38)(H,32,37)
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23n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-Methyl-scopolamine to muscarinic acetylcholine receptor M4 of rat heart NG108-15 cells


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50012345
PNG
(11-{2-[4-(9-Amino-nonyl)-piperazin-1-yl]-acetyl}-5...)
Show SMILES NCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C27H38N6O2/c28-14-8-4-2-1-3-5-9-16-31-17-19-32(20-18-31)21-25(34)33-24-13-7-6-11-22(24)27(35)30-23-12-10-15-29-26(23)33/h6-7,10-13,15H,1-5,8-9,14,16-21,28H2,(H,30,35)
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24n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012345
PNG
(11-{2-[4-(9-Amino-nonyl)-piperazin-1-yl]-acetyl}-5...)
Show SMILES NCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C27H38N6O2/c28-14-8-4-2-1-3-5-9-16-31-17-19-32(20-18-31)21-25(34)33-24-13-7-6-11-22(24)27(35)30-23-12-10-15-29-26(23)33/h6-7,10-13,15H,1-5,8-9,14,16-21,28H2,(H,30,35)
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24n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-Methyl-scopolamine to Muscarinic acetylcholine receptor M1 of transfected A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50012360
PNG
(11-{2-[4-(8-Amino-octyl)-piperazin-1-yl]-acetyl}-5...)
Show SMILES NCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C26H36N6O2/c27-13-7-3-1-2-4-8-15-30-16-18-31(19-17-30)20-24(33)32-23-12-6-5-10-21(23)26(34)29-22-11-9-14-28-25(22)32/h5-6,9-12,14H,1-4,7-8,13,15-20,27H2,(H,29,34)
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26n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM39341
PNG
(11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6...)
Show SMILES CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)
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29n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M1 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012338
PNG
((6-{4-[2-Oxo-2-(6-oxo-5,6-dihydro-benzo[e]pyrido[3...)
Show SMILES CC(C)(C)OC(=O)NCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C29H40N6O4/c1-29(2,3)39-28(38)31-14-8-4-5-9-16-33-17-19-34(20-18-33)21-25(36)35-24-13-7-6-11-22(24)27(37)32-23-12-10-15-30-26(23)35/h6-7,10-13,15H,4-5,8-9,14,16-21H2,1-3H3,(H,31,38)(H,32,37)
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37n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M1 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50012371
PNG
(CHEMBL70154 | N-(10-{4-[2-Oxo-2-(6-oxo-5,6-dihydro...)
Show SMILES CC(=O)NCCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C30H42N6O3/c1-24(37)31-16-10-6-4-2-3-5-7-11-18-34-19-21-35(22-20-34)23-28(38)36-27-15-9-8-13-25(27)30(39)33-26-14-12-17-32-29(26)36/h8-9,12-15,17H,2-7,10-11,16,18-23H2,1H3,(H,31,37)(H,33,39)
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43n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50012338
PNG
((6-{4-[2-Oxo-2-(6-oxo-5,6-dihydro-benzo[e]pyrido[3...)
Show SMILES CC(C)(C)OC(=O)NCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C29H40N6O4/c1-29(2,3)39-28(38)31-14-8-4-5-9-16-33-17-19-34(20-18-33)21-25(36)35-24-13-7-6-11-22(24)27(37)32-23-12-10-15-30-26(23)35/h6-7,10-13,15H,4-5,8-9,14,16-21H2,1-3H3,(H,31,38)(H,32,37)
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46n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M3 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50012327
PNG
(CHEMBL68292 | N-(9-{4-[2-Oxo-2-(6-oxo-5,6-dihydro-...)
Show SMILES CC(=O)NCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C29H40N6O3/c1-23(36)30-15-9-5-3-2-4-6-10-17-33-18-20-34(21-19-33)22-27(37)35-26-14-8-7-12-24(26)29(38)32-25-13-11-16-31-28(25)35/h7-8,11-14,16H,2-6,9-10,15,17-22H2,1H3,(H,30,36)(H,32,38)
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50n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM82376
PNG
(CAS_80880-90-6 | NSC_5387 | TELENZEPINE)
Show SMILES CN1CCN(CC(=O)N2c3c(C)scc3C(=O)Nc3ccccc23)CC1
Show InChI InChI=1S/C19H22N4O2S/c1-13-18-14(12-26-13)19(25)20-15-5-3-4-6-16(15)23(18)17(24)11-22-9-7-21(2)8-10-22/h3-6,12H,7-11H2,1-2H3,(H,20,25)
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50n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012327
PNG
(CHEMBL68292 | N-(9-{4-[2-Oxo-2-(6-oxo-5,6-dihydro-...)
Show SMILES CC(=O)NCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C29H40N6O3/c1-23(36)30-15-9-5-3-2-4-6-10-17-33-18-20-34(21-19-33)22-27(37)35-26-14-8-7-12-24(26)29(38)32-25-13-11-16-31-28(25)35/h7-8,11-14,16H,2-6,9-10,15,17-22H2,1H3,(H,30,36)(H,32,38)
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52n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-Methyl-scopolamine to Muscarinic acetylcholine receptor M1 of transfected A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012365
PNG
(11-{2-[4-(2-Chloro-ethyl)-piperazin-1-yl]-acetyl}-...)
Show SMILES ClCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C20H22ClN5O2/c21-7-9-24-10-12-25(13-11-24)14-18(27)26-17-6-2-1-4-15(17)20(28)23-16-5-3-8-22-19(16)26/h1-6,8H,7,9-14H2,(H,23,28)
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52n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-Methyl-scopolamine to Muscarinic acetylcholine receptor M1 of transfected A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50012351
PNG
(11-{2-[4-(7-Amino-heptyl)-piperazin-1-yl]-acetyl}-...)
Show SMILES NCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C25H34N6O2/c26-12-6-2-1-3-7-14-29-15-17-30(18-16-29)19-23(32)31-22-11-5-4-9-20(22)25(33)28-21-10-8-13-27-24(21)31/h4-5,8-11,13H,1-3,6-7,12,14-19,26H2,(H,28,33)
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57n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012357
PNG
(2-(5-{4-[2-Oxo-2-(6-oxo-5,6-dihydro-benzo[e]pyrido...)
Show SMILES O=C(CN1CCN(CCCCCN2C(=O)c3ccccc3C2=O)CC1)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C31H32N6O4/c38-27(37-26-13-5-4-11-24(26)29(39)33-25-12-8-14-32-28(25)37)21-35-19-17-34(18-20-35)15-6-1-7-16-36-30(40)22-9-2-3-10-23(22)31(36)41/h2-5,8-14H,1,6-7,15-21H2,(H,33,39)
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60n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M1 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012351
PNG
(11-{2-[4-(7-Amino-heptyl)-piperazin-1-yl]-acetyl}-...)
Show SMILES NCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C25H34N6O2/c26-12-6-2-1-3-7-14-29-15-17-30(18-16-29)19-23(32)31-22-11-5-4-9-20(22)25(33)28-21-10-8-13-27-24(21)31/h4-5,8-11,13H,1-3,6-7,12,14-19,26H2,(H,28,33)
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66n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-Methyl-scopolamine to Muscarinic acetylcholine receptor M1 of transfected A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012371
PNG
(CHEMBL70154 | N-(10-{4-[2-Oxo-2-(6-oxo-5,6-dihydro...)
Show SMILES CC(=O)NCCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C30H42N6O3/c1-24(37)31-16-10-6-4-2-3-5-7-11-18-34-19-21-35(22-20-34)23-28(38)36-27-15-9-8-13-25(27)30(39)33-26-14-12-17-32-29(26)36/h8-9,12-15,17H,2-7,10-11,16,18-23H2,1H3,(H,31,37)(H,33,39)
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75n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-Methyl-scopolamine to Muscarinic acetylcholine receptor M1 of transfected A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50012365
PNG
(11-{2-[4-(2-Chloro-ethyl)-piperazin-1-yl]-acetyl}-...)
Show SMILES ClCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C20H22ClN5O2/c21-7-9-24-10-12-25(13-11-24)14-18(27)26-17-6-2-1-4-15(17)20(28)23-16-5-3-8-22-19(16)26/h1-6,8H,7,9-14H2,(H,23,28)
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78n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
The compound was tested for the inhibition of binding of [3H]-N-Methyl-scopolamine to Muscarinic acetylcholine receptor M3 of transfected A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50012331
PNG
(2-(4-{4-[2-Oxo-2-(6-oxo-5,6-dihydro-benzo[e]pyrido...)
Show SMILES O=C(CN1CCN(CCCCN2C(=O)c3ccccc3C2=O)CC1)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C30H30N6O4/c37-26(36-25-12-4-3-10-23(25)28(38)32-24-11-7-13-31-27(24)36)20-34-18-16-33(17-19-34)14-5-6-15-35-29(39)21-8-1-2-9-22(21)30(35)40/h1-4,7-13H,5-6,14-20H2,(H,32,38)
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89n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50012331
PNG
(2-(4-{4-[2-Oxo-2-(6-oxo-5,6-dihydro-benzo[e]pyrido...)
Show SMILES O=C(CN1CCN(CCCCN2C(=O)c3ccccc3C2=O)CC1)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C30H30N6O4/c37-26(36-25-12-4-3-10-23(25)28(38)32-24-11-7-13-31-27(24)36)20-34-18-16-33(17-19-34)14-5-6-15-35-29(39)21-8-1-2-9-22(21)30(35)40/h1-4,7-13H,5-6,14-20H2,(H,32,38)
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120n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M3 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(RAT)
BDBM50012365
PNG
(11-{2-[4-(2-Chloro-ethyl)-piperazin-1-yl]-acetyl}-...)
Show SMILES ClCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C20H22ClN5O2/c21-7-9-24-10-12-25(13-11-24)14-18(27)26-17-6-2-1-4-15(17)20(28)23-16-5-3-8-22-19(16)26/h1-6,8H,7,9-14H2,(H,23,28)
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130n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-Methyl-scopolamine to Muscarinic acetylcholine receptor M4 of NG108-15 cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012331
PNG
(2-(4-{4-[2-Oxo-2-(6-oxo-5,6-dihydro-benzo[e]pyrido...)
Show SMILES O=C(CN1CCN(CCCCN2C(=O)c3ccccc3C2=O)CC1)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C30H30N6O4/c37-26(36-25-12-4-3-10-23(25)28(38)32-24-11-7-13-31-27(24)36)20-34-18-16-33(17-19-34)14-5-6-15-35-29(39)21-8-1-2-9-22(21)30(35)40/h1-4,7-13H,5-6,14-20H2,(H,32,38)
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170n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M1 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50012365
PNG
(11-{2-[4-(2-Chloro-ethyl)-piperazin-1-yl]-acetyl}-...)
Show SMILES ClCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C20H22ClN5O2/c21-7-9-24-10-12-25(13-11-24)14-18(27)26-17-6-2-1-4-15(17)20(28)23-16-5-3-8-22-19(16)26/h1-6,8H,7,9-14H2,(H,23,28)
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210n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(RAT)
BDBM50012331
PNG
(2-(4-{4-[2-Oxo-2-(6-oxo-5,6-dihydro-benzo[e]pyrido...)
Show SMILES O=C(CN1CCN(CCCCN2C(=O)c3ccccc3C2=O)CC1)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C30H30N6O4/c37-26(36-25-12-4-3-10-23(25)28(38)32-24-11-7-13-31-27(24)36)20-34-18-16-33(17-19-34)14-5-6-15-35-29(39)21-8-1-2-9-22(21)30(35)40/h1-4,7-13H,5-6,14-20H2,(H,32,38)
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210n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-Methyl-scopolamine to muscarinic acetylcholine receptor M4 of rat heart NG108-15 cells


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(RAT)
BDBM50012340
PNG
(11-[2-(4-Benzyl-piperazin-1-yl)-acetyl]-5,11-dihyd...)
Show SMILES O=C(CN1CCN(Cc2ccccc2)CC1)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C25H25N5O2/c31-23(18-29-15-13-28(14-16-29)17-19-7-2-1-3-8-19)30-22-11-5-4-9-20(22)25(32)27-21-10-6-12-26-24(21)30/h1-12H,13-18H2,(H,27,32)
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220n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-Methyl-scopolamine to muscarinic acetylcholine receptor M4 of rat heart NG108-15 cells


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM39341
PNG
(11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6...)
Show SMILES CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)
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240n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M3 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50012340
PNG
(11-[2-(4-Benzyl-piperazin-1-yl)-acetyl]-5,11-dihyd...)
Show SMILES O=C(CN1CCN(Cc2ccccc2)CC1)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C25H25N5O2/c31-23(18-29-15-13-28(14-16-29)17-19-7-2-1-3-8-19)30-22-11-5-4-9-20(22)25(32)27-21-10-6-12-26-24(21)30/h1-12H,13-18H2,(H,27,32)
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240n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50012340
PNG
(11-[2-(4-Benzyl-piperazin-1-yl)-acetyl]-5,11-dihyd...)
Show SMILES O=C(CN1CCN(Cc2ccccc2)CC1)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C25H25N5O2/c31-23(18-29-15-13-28(14-16-29)17-19-7-2-1-3-8-19)30-22-11-5-4-9-20(22)25(32)27-21-10-6-12-26-24(21)30/h1-12H,13-18H2,(H,27,32)
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240n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M3 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(RAT)
BDBM39341
PNG
(11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6...)
Show SMILES CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)
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330n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-Methyl-scopolamine to muscarinic acetylcholine receptor M4 of rat heart NG108-15 cells


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012340
PNG
(11-[2-(4-Benzyl-piperazin-1-yl)-acetyl]-5,11-dihyd...)
Show SMILES O=C(CN1CCN(Cc2ccccc2)CC1)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C25H25N5O2/c31-23(18-29-15-13-28(14-16-29)17-19-7-2-1-3-8-19)30-22-11-5-4-9-20(22)25(32)27-21-10-6-12-26-24(21)30/h1-12H,13-18H2,(H,27,32)
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330n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M1 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50406547
PNG
(CHEMBL2112217)
Show SMILES O=C(CN1CCNCC1)N1c2ncccc2NC(=O)c2cccnc12
Show InChI InChI=1S/C17H18N6O2/c24-14(11-22-9-7-18-8-10-22)23-15-12(3-1-5-19-15)17(25)21-13-4-2-6-20-16(13)23/h1-6,18H,7-11H2,(H,21,25)
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370n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M1 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM39341
PNG
(11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6...)
Show SMILES CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)
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610n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012346
PNG
(CHEMBL70003 | N-(2-{4-[2-Oxo-2-(6-oxo-5,6-dihydro-...)
Show SMILES CC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C22H26N6O3/c1-16(29)23-9-10-26-11-13-27(14-12-26)15-20(30)28-19-7-3-2-5-17(19)22(31)25-18-6-4-8-24-21(18)28/h2-8H,9-15H2,1H3,(H,23,29)(H,25,31)
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670n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M1 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50012349
PNG
(2-(3-{4-[2-Oxo-2-(6-oxo-5,6-dihydro-benzo[e]pyrido...)
Show SMILES O=C(CN1CCN(CCCN2C(=O)c3ccccc3C2=O)CC1)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C29H28N6O4/c36-25(35-24-11-4-3-9-22(24)27(37)31-23-10-5-12-30-26(23)35)19-33-17-15-32(16-18-33)13-6-14-34-28(38)20-7-1-2-8-21(20)29(34)39/h1-5,7-12H,6,13-19H2,(H,31,37)
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840n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50012363
PNG
(CHEMBL305403 | N-(2-Amino-ethyl)-4-{4-[2-oxo-2-(6-...)
Show SMILES NCCNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc34)CC2)cc1
Show InChI InChI=1S/C28H31N7O3/c29-11-13-31-27(37)21-9-7-20(8-10-21)18-33-14-16-34(17-15-33)19-25(36)35-24-6-2-1-4-22(24)28(38)32-23-5-3-12-30-26(23)35/h1-10,12H,11,13-19,29H2,(H,31,37)(H,32,38)
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960n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50012346
PNG
(CHEMBL70003 | N-(2-{4-[2-Oxo-2-(6-oxo-5,6-dihydro-...)
Show SMILES CC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C22H26N6O3/c1-16(29)23-9-10-26-11-13-27(14-12-26)15-20(30)28-19-7-3-2-5-17(19)22(31)25-18-6-4-8-24-21(18)28/h2-8H,9-15H2,1H3,(H,23,29)(H,25,31)
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970n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M3 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(RAT)
BDBM50012363
PNG
(CHEMBL305403 | N-(2-Amino-ethyl)-4-{4-[2-oxo-2-(6-...)
Show SMILES NCCNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc34)CC2)cc1
Show InChI InChI=1S/C28H31N7O3/c29-11-13-31-27(37)21-9-7-20(8-10-21)18-33-14-16-34(17-15-33)19-25(36)35-24-6-2-1-4-22(24)28(38)32-23-5-3-12-30-26(23)35/h1-10,12H,11,13-19,29H2,(H,31,37)(H,32,38)
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1.04E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-Methyl-scopolamine to muscarinic acetylcholine receptor M4 of rat heart NG108-15 cells


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50012341
PNG
(CHEMBL69458 | [4-(4-{4-[2-Oxo-2-(6-oxo-5,6-dihydro...)
Show SMILES CC(C)(C)OC(=O)NCCCCNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc34)CC2)cc1
Show InChI InChI=1S/C35H43N7O5/c1-35(2,3)47-34(46)38-17-7-6-16-37-32(44)26-14-12-25(13-15-26)23-40-19-21-41(22-20-40)24-30(43)42-29-11-5-4-9-27(29)33(45)39-28-10-8-18-36-31(28)42/h4-5,8-15,18H,6-7,16-17,19-24H2,1-3H3,(H,37,44)(H,38,46)(H,39,45)
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1.09E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012366
PNG
(11-{2-[4-(5-Amino-pentyl)-piperazin-1-yl]-acetyl}-...)
Show SMILES NCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C23H30N6O2/c24-10-4-1-5-12-27-13-15-28(16-14-27)17-21(30)29-20-9-3-2-7-18(20)23(31)26-19-8-6-11-25-22(19)29/h2-3,6-9,11H,1,4-5,10,12-17,24H2,(H,26,31)
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1.17E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M1 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012339
PNG
(11-{2-[4-(2-Amino-ethyl)-piperazin-1-yl]-acetyl}-5...)
Show SMILES NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C20H24N6O2/c21-7-9-24-10-12-25(13-11-24)14-18(27)26-17-6-2-1-4-15(17)20(28)23-16-5-3-8-22-19(16)26/h1-6,8H,7,9-14,21H2,(H,23,28)
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1.19E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M1 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012372
PNG
(11-{2-[4-(6-Amino-hexyl)-piperazin-1-yl]-acetyl}-5...)
Show SMILES NCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C24H32N6O2/c25-11-5-1-2-6-13-28-14-16-29(17-15-28)18-22(31)30-21-10-4-3-8-19(21)24(32)27-20-9-7-12-26-23(20)30/h3-4,7-10,12H,1-2,5-6,11,13-18,25H2,(H,27,32)
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1.31E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M1 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50406547
PNG
(CHEMBL2112217)
Show SMILES O=C(CN1CCNCC1)N1c2ncccc2NC(=O)c2cccnc12
Show InChI InChI=1S/C17H18N6O2/c24-14(11-22-9-7-18-8-10-22)23-15-12(3-1-5-19-15)17(25)21-13-4-2-6-20-16(13)23/h1-6,18H,7-11H2,(H,21,25)
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1.31E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M3 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50012372
PNG
(11-{2-[4-(6-Amino-hexyl)-piperazin-1-yl]-acetyl}-5...)
Show SMILES NCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C24H32N6O2/c25-11-5-1-2-6-13-28-14-16-29(17-15-28)18-22(31)30-21-10-4-3-8-19(21)24(32)27-20-9-7-12-26-23(20)30/h3-4,7-10,12H,1-2,5-6,11,13-18,25H2,(H,27,32)
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1.34E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50012370
PNG
(11-[2-(4-Prop-2-ynyl-piperazin-1-yl)-acetyl]-5,11-...)
Show SMILES O=C(CN1CCN(CC#C)CC1)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C21H21N5O2/c1-2-10-24-11-13-25(14-12-24)15-19(27)26-18-8-4-3-6-16(18)21(28)23-17-7-5-9-22-20(17)26/h1,3-9H,10-15H2,(H,23,28)
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1.37E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012363
PNG
(CHEMBL305403 | N-(2-Amino-ethyl)-4-{4-[2-oxo-2-(6-...)
Show SMILES NCCNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc34)CC2)cc1
Show InChI InChI=1S/C28H31N7O3/c29-11-13-31-27(37)21-9-7-20(8-10-21)18-33-14-16-34(17-15-33)19-25(36)35-24-6-2-1-4-22(24)28(38)32-23-5-3-12-30-26(23)35/h1-10,12H,11,13-19,29H2,(H,31,37)(H,32,38)
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1.39E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M1 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(RAT)
BDBM50406547
PNG
(CHEMBL2112217)
Show SMILES O=C(CN1CCNCC1)N1c2ncccc2NC(=O)c2cccnc12
Show InChI InChI=1S/C17H18N6O2/c24-14(11-22-9-7-18-8-10-22)23-15-12(3-1-5-19-15)17(25)21-13-4-2-6-20-16(13)23/h1-6,18H,7-11H2,(H,21,25)
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1.67E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-Methyl-scopolamine to muscarinic acetylcholine receptor M4 of rat heart NG108-15 cells


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012370
PNG
(11-[2-(4-Prop-2-ynyl-piperazin-1-yl)-acetyl]-5,11-...)
Show SMILES O=C(CN1CCN(CC#C)CC1)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C21H21N5O2/c1-2-10-24-11-13-25(14-12-24)15-19(27)26-18-8-4-3-6-16(18)21(28)23-17-7-5-9-22-20(17)26/h1,3-9H,10-15H2,(H,23,28)
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1.67E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M1 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012341
PNG
(CHEMBL69458 | [4-(4-{4-[2-Oxo-2-(6-oxo-5,6-dihydro...)
Show SMILES CC(C)(C)OC(=O)NCCCCNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc34)CC2)cc1
Show InChI InChI=1S/C35H43N7O5/c1-35(2,3)47-34(46)38-17-7-6-16-37-32(44)26-14-12-25(13-15-26)23-40-19-21-41(22-20-40)24-30(43)42-29-11-5-4-9-27(29)33(45)39-28-10-8-18-36-31(28)42/h4-5,8-15,18H,6-7,16-17,19-24H2,1-3H3,(H,37,44)(H,38,46)(H,39,45)
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1.68E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M1 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50012332
PNG
(11-{2-[4-(4-Amino-butyl)-piperazin-1-yl]-acetyl}-5...)
Show SMILES NCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C22H28N6O2/c23-9-3-4-11-26-12-14-27(15-13-26)16-20(29)28-19-8-2-1-6-17(19)22(30)25-18-7-5-10-24-21(18)28/h1-2,5-8,10H,3-4,9,11-16,23H2,(H,25,30)
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1.74E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012349
PNG
(2-(3-{4-[2-Oxo-2-(6-oxo-5,6-dihydro-benzo[e]pyrido...)
Show SMILES O=C(CN1CCN(CCCN2C(=O)c3ccccc3C2=O)CC1)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C29H28N6O4/c36-25(35-24-11-4-3-9-22(24)27(37)31-23-10-5-12-30-26(23)35)19-33-17-15-32(16-18-33)13-6-14-34-28(38)20-7-1-2-8-21(20)29(34)39/h1-5,7-12H,6,13-19H2,(H,31,37)
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1.81E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M1 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50012339
PNG
(11-{2-[4-(2-Amino-ethyl)-piperazin-1-yl]-acetyl}-5...)
Show SMILES NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C20H24N6O2/c21-7-9-24-10-12-25(13-11-24)14-18(27)26-17-6-2-1-4-15(17)20(28)23-16-5-3-8-22-19(16)26/h1-6,8H,7,9-14,21H2,(H,23,28)
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1.97E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M3 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50012368
PNG
(CHEMBL304109 | [2-(4-{4-[2-Oxo-2-(6-oxo-5,6-dihydr...)
Show SMILES CC(C)(C)OC(=O)NCCNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc34)CC2)cc1
Show InChI InChI=1S/C33H39N7O5/c1-33(2,3)45-32(44)36-16-15-35-30(42)24-12-10-23(11-13-24)21-38-17-19-39(20-18-38)22-28(41)40-27-9-5-4-7-25(27)31(43)37-26-8-6-14-34-29(26)40/h4-14H,15-22H2,1-3H3,(H,35,42)(H,36,44)(H,37,43)
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2.50E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50012346
PNG
(CHEMBL70003 | N-(2-{4-[2-Oxo-2-(6-oxo-5,6-dihydro-...)
Show SMILES CC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C22H26N6O3/c1-16(29)23-9-10-26-11-13-27(14-12-26)15-20(30)28-19-7-3-2-5-17(19)22(31)25-18-6-4-8-24-21(18)28/h2-8H,9-15H2,1H3,(H,23,29)(H,25,31)
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2.52E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(RAT)
BDBM50012346
PNG
(CHEMBL70003 | N-(2-{4-[2-Oxo-2-(6-oxo-5,6-dihydro-...)
Show SMILES CC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C22H26N6O3/c1-16(29)23-9-10-26-11-13-27(14-12-26)15-20(30)28-19-7-3-2-5-17(19)22(31)25-18-6-4-8-24-21(18)28/h2-8H,9-15H2,1H3,(H,23,29)(H,25,31)
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2.57E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-Methyl-scopolamine to muscarinic acetylcholine receptor M4 of rat heart NG108-15 cells


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50012328
PNG
(CHEMBL304391 | N-Methyl-4-{4-[2-oxo-2-(6-oxo-5,6-d...)
Show SMILES CNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc34)CC2)cc1
Show InChI InChI=1S/C27H28N6O3/c1-28-26(35)20-10-8-19(9-11-20)17-31-13-15-32(16-14-31)18-24(34)33-23-7-3-2-5-21(23)27(36)30-22-6-4-12-29-25(22)33/h2-12H,13-18H2,1H3,(H,28,35)(H,30,36)
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2.65E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012328
PNG
(CHEMBL304391 | N-Methyl-4-{4-[2-oxo-2-(6-oxo-5,6-d...)
Show SMILES CNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc34)CC2)cc1
Show InChI InChI=1S/C27H28N6O3/c1-28-26(35)20-10-8-19(9-11-20)17-31-13-15-32(16-14-31)18-24(34)33-23-7-3-2-5-21(23)27(36)30-22-6-4-12-29-25(22)33/h2-12H,13-18H2,1H3,(H,28,35)(H,30,36)
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2.84E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M1 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(RAT)
BDBM50012339
PNG
(11-{2-[4-(2-Amino-ethyl)-piperazin-1-yl]-acetyl}-5...)
Show SMILES NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C20H24N6O2/c21-7-9-24-10-12-25(13-11-24)14-18(27)26-17-6-2-1-4-15(17)20(28)23-16-5-3-8-22-19(16)26/h1-6,8H,7,9-14,21H2,(H,23,28)
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2.84E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-Methyl-scopolamine to muscarinic acetylcholine receptor M4 of rat heart NG108-15 cells


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(RAT)
BDBM50012328
PNG
(CHEMBL304391 | N-Methyl-4-{4-[2-oxo-2-(6-oxo-5,6-d...)
Show SMILES CNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc34)CC2)cc1
Show InChI InChI=1S/C27H28N6O3/c1-28-26(35)20-10-8-19(9-11-20)17-31-13-15-32(16-14-31)18-24(34)33-23-7-3-2-5-21(23)27(36)30-22-6-4-12-29-25(22)33/h2-12H,13-18H2,1H3,(H,28,35)(H,30,36)
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2.94E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-Methyl-scopolamine to muscarinic acetylcholine receptor M4 of rat heart NG108-15 cells


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50012339
PNG
(11-{2-[4-(2-Amino-ethyl)-piperazin-1-yl]-acetyl}-5...)
Show SMILES NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C20H24N6O2/c21-7-9-24-10-12-25(13-11-24)14-18(27)26-17-6-2-1-4-15(17)20(28)23-16-5-3-8-22-19(16)26/h1-6,8H,7,9-14,21H2,(H,23,28)
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3.04E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012332
PNG
(11-{2-[4-(4-Amino-butyl)-piperazin-1-yl]-acetyl}-5...)
Show SMILES NCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C22H28N6O2/c23-9-3-4-11-26-12-14-27(15-13-26)16-20(29)28-19-8-2-1-6-17(19)22(30)25-18-7-5-10-24-21(18)28/h1-2,5-8,10H,3-4,9,11-16,23H2,(H,25,30)
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3.08E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M1 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50012364
PNG
(11-{2-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-acetyl}...)
Show SMILES OCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C20H23N5O3/c26-13-12-23-8-10-24(11-9-23)14-18(27)25-17-6-2-1-4-15(17)20(28)22-16-5-3-7-21-19(16)25/h1-7,26H,8-14H2,(H,22,28)
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3.20E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50406547
PNG
(CHEMBL2112217)
Show SMILES O=C(CN1CCNCC1)N1c2ncccc2NC(=O)c2cccnc12
Show InChI InChI=1S/C17H18N6O2/c24-14(11-22-9-7-18-8-10-22)23-15-12(3-1-5-19-15)17(25)21-13-4-2-6-20-16(13)23/h1-6,18H,7-11H2,(H,21,25)
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3.34E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50012350
PNG
(CHEMBL422053 | [3-(2-{4-[2-Oxo-2-(6-oxo-5,6-dihydr...)
Show SMILES CC(C)(C)OC(=O)NCCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C29H39N7O5/c1-29(2,3)41-28(40)32-13-7-11-24(37)30-14-15-34-16-18-35(19-17-34)20-25(38)36-23-10-5-4-8-21(23)27(39)33-22-9-6-12-31-26(22)36/h4-6,8-10,12H,7,11,13-20H2,1-3H3,(H,30,37)(H,32,40)(H,33,39)
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3.34E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50012341
PNG
(CHEMBL69458 | [4-(4-{4-[2-Oxo-2-(6-oxo-5,6-dihydro...)
Show SMILES CC(C)(C)OC(=O)NCCCCNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc34)CC2)cc1
Show InChI InChI=1S/C35H43N7O5/c1-35(2,3)47-34(46)38-17-7-6-16-37-32(44)26-14-12-25(13-15-26)23-40-19-21-41(22-20-40)24-30(43)42-29-11-5-4-9-27(29)33(45)39-28-10-8-18-36-31(28)42/h4-5,8-15,18H,6-7,16-17,19-24H2,1-3H3,(H,37,44)(H,38,46)(H,39,45)
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3.47E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M3 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50012352
PNG
(11-[2-(4-Methyl-piperazin-1-yl)-acetyl]-8-methylsu...)
Show SMILES CSc1ccc2N(C(=O)CN3CCN(C)CC3)c3ncccc3NC(=O)c2c1
Show InChI InChI=1S/C20H23N5O2S/c1-23-8-10-24(11-9-23)13-18(26)25-17-6-5-14(28-2)12-15(17)20(27)22-16-4-3-7-21-19(16)25/h3-7,12H,8-11,13H2,1-2H3,(H,22,27)
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3.62E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M3 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50012363
PNG
(CHEMBL305403 | N-(2-Amino-ethyl)-4-{4-[2-oxo-2-(6-...)
Show SMILES NCCNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc34)CC2)cc1
Show InChI InChI=1S/C28H31N7O3/c29-11-13-31-27(37)21-9-7-20(8-10-21)18-33-14-16-34(17-15-33)19-25(36)35-24-6-2-1-4-22(24)28(38)32-23-5-3-12-30-26(23)35/h1-10,12H,11,13-19,29H2,(H,31,37)(H,32,38)
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3.65E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M3 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012343
PNG
(11-{2-[4-(3-Amino-propyl)-piperazin-1-yl]-acetyl}-...)
Show SMILES NCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C21H26N6O2/c22-8-4-10-25-11-13-26(14-12-25)15-19(28)27-18-7-2-1-5-16(18)21(29)24-17-6-3-9-23-20(17)27/h1-3,5-7,9H,4,8,10-15,22H2,(H,24,29)
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3.87E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M1 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50012328
PNG
(CHEMBL304391 | N-Methyl-4-{4-[2-oxo-2-(6-oxo-5,6-d...)
Show SMILES CNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc34)CC2)cc1
Show InChI InChI=1S/C27H28N6O3/c1-28-26(35)20-10-8-19(9-11-20)17-31-13-15-32(16-14-31)18-24(34)33-23-7-3-2-5-21(23)27(36)30-22-6-4-12-29-25(22)33/h2-12H,13-18H2,1H3,(H,28,35)(H,30,36)
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4.02E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of binding of [3H]-N-Methyl-scopolamine to mmuscarinic acetylcholine receptor M3 of transfected rat A9L cells


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50012350
PNG
(CHEMBL422053 | [3-(2-{4-[2-Oxo-2-(6-oxo-5,6-dihydr...)
Show SMILES CC(C)(C)OC(=O)NCCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C29H39N7O5/c1-29(2,3)41-28(40)32-13-7-11-24(37)30-14-15-34-16-18-35(19-17-34)20-25(38)36-23-10-5-4-8-21(23)27(39)33-22-9-6-12-31-26(22)36/h4-6,8-10,12H,7,11,13-20H2,1-3H3,(H,30,37)(H,32,40)(H,33,39)
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4.10E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M3 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012359
PNG
(3-Amino-N-(2-{4-[2-oxo-2-(6-oxo-5,6-dihydro-benzo[...)
Show SMILES NCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C23H29N7O3/c24-8-7-20(31)25-10-11-28-12-14-29(15-13-28)16-21(32)30-19-6-2-1-4-17(19)23(33)27-18-5-3-9-26-22(18)30/h1-6,9H,7-8,10-16,24H2,(H,25,31)(H,27,33)
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4.34E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M1 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012373
PNG
(9-Hydroxymethyl-11-[2-(4-methyl-piperazin-1-yl)-ac...)
Show SMILES CN1CCN(CC(=O)N2c3cc(CO)ccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C20H23N5O3/c1-23-7-9-24(10-8-23)12-18(27)25-17-11-14(13-26)4-5-15(17)20(28)22-16-3-2-6-21-19(16)25/h2-6,11,26H,7-10,12-13H2,1H3,(H,22,28)
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4.40E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M1 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50012356
PNG
(9-(tert-Butyl-dimethyl-silanyloxymethyl)-11-[2-(4-...)
Show SMILES CN1CCN(CC(=O)N2c3cc(CO[Si](C)(C)C(C)(C)C)ccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C26H37N5O3Si/c1-26(2,3)35(5,6)34-18-19-9-10-20-22(16-19)31(23(32)17-30-14-12-29(4)13-15-30)24-21(28-25(20)33)8-7-11-27-24/h7-11,16H,12-15,17-18H2,1-6H3,(H,28,33)
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4.40E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
The compound was tested for the inhibition of binding of [3H]-N-Methyl-scopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membra...


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50012373
PNG
(9-Hydroxymethyl-11-[2-(4-methyl-piperazin-1-yl)-ac...)
Show SMILES CN1CCN(CC(=O)N2c3cc(CO)ccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C20H23N5O3/c1-23-7-9-24(10-8-23)12-18(27)25-17-11-14(13-26)4-5-15(17)20(28)22-16-3-2-6-21-19(16)25/h2-6,11,26H,7-10,12-13H2,1H3,(H,22,28)
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4.40E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M3 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012352
PNG
(11-[2-(4-Methyl-piperazin-1-yl)-acetyl]-8-methylsu...)
Show SMILES CSc1ccc2N(C(=O)CN3CCN(C)CC3)c3ncccc3NC(=O)c2c1
Show InChI InChI=1S/C20H23N5O2S/c1-23-8-10-24(11-9-23)13-18(26)25-17-6-5-14(28-2)12-15(17)20(27)22-16-4-3-7-21-19(16)25/h3-7,12H,8-11,13H2,1-2H3,(H,22,27)
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4.66E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M1 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012350
PNG
(CHEMBL422053 | [3-(2-{4-[2-Oxo-2-(6-oxo-5,6-dihydr...)
Show SMILES CC(C)(C)OC(=O)NCCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C29H39N7O5/c1-29(2,3)41-28(40)32-13-7-11-24(37)30-14-15-34-16-18-35(19-17-34)20-25(38)36-23-10-5-4-8-21(23)27(39)33-22-9-6-12-31-26(22)36/h4-6,8-10,12H,7,11,13-20H2,1-3H3,(H,30,37)(H,32,40)(H,33,39)
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4.80E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M1 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50012343
PNG
(11-{2-[4-(3-Amino-propyl)-piperazin-1-yl]-acetyl}-...)
Show SMILES NCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C21H26N6O2/c22-8-4-10-25-11-13-26(14-12-25)15-19(28)27-18-7-2-1-5-16(18)21(29)24-17-6-3-9-23-20(17)27/h1-3,5-7,9H,4,8,10-15,22H2,(H,24,29)
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5.12E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012364
PNG
(11-{2-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-acetyl}...)
Show SMILES OCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C20H23N5O3/c26-13-12-23-8-10-24(11-9-23)14-18(27)25-17-6-2-1-4-15(17)20(28)22-16-5-3-7-21-19(16)25/h1-7,26H,8-14H2,(H,22,28)
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5.80E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M1 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50012359
PNG
(3-Amino-N-(2-{4-[2-oxo-2-(6-oxo-5,6-dihydro-benzo[...)
Show SMILES NCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C23H29N7O3/c24-8-7-20(31)25-10-11-28-12-14-29(15-13-28)16-21(32)30-19-6-2-1-4-17(19)23(33)27-18-5-3-9-26-22(18)30/h1-6,9H,7-8,10-16,24H2,(H,25,31)(H,27,33)
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5.84E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50012366
PNG
(11-{2-[4-(5-Amino-pentyl)-piperazin-1-yl]-acetyl}-...)
Show SMILES NCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C23H30N6O2/c24-10-4-1-5-12-27-13-15-28(16-14-27)17-21(30)29-20-9-3-2-7-18(20)23(31)26-19-8-6-11-25-22(19)29/h2-3,6-9,11H,1,4-5,10,12-17,24H2,(H,26,31)
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5.89E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50012362
PNG
(CHEMBL70133 | [2-(2-{4-[2-Oxo-2-(6-oxo-5,6-dihydro...)
Show SMILES CC(C)(C)OC(=O)NCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C28H37N7O5/c1-28(2,3)40-27(39)31-12-10-23(36)29-13-14-33-15-17-34(18-16-33)19-24(37)35-22-9-5-4-7-20(22)26(38)32-21-8-6-11-30-25(21)35/h4-9,11H,10,12-19H2,1-3H3,(H,29,36)(H,31,39)(H,32,38)
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6.06E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50012362
PNG
(CHEMBL70133 | [2-(2-{4-[2-Oxo-2-(6-oxo-5,6-dihydro...)
Show SMILES CC(C)(C)OC(=O)NCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C28H37N7O5/c1-28(2,3)40-27(39)31-12-10-23(36)29-13-14-33-15-17-34(18-16-33)19-24(37)35-22-9-5-4-7-20(22)26(38)32-21-8-6-11-30-25(21)35/h4-9,11H,10,12-19H2,1-3H3,(H,29,36)(H,31,39)(H,32,38)
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6.19E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M3 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50012342
PNG
(4-Amino-N-(2-{4-[2-oxo-2-(6-oxo-5,6-dihydro-benzo[...)
Show SMILES NCCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C24H31N7O3/c25-9-3-8-21(32)26-11-12-29-13-15-30(16-14-29)17-22(33)31-20-7-2-1-5-18(20)24(34)28-19-6-4-10-27-23(19)31/h1-2,4-7,10H,3,8-9,11-17,25H2,(H,26,32)(H,28,34)
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6.34E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50012359
PNG
(3-Amino-N-(2-{4-[2-oxo-2-(6-oxo-5,6-dihydro-benzo[...)
Show SMILES NCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C23H29N7O3/c24-8-7-20(31)25-10-11-28-12-14-29(15-13-28)16-21(32)30-19-6-2-1-4-17(19)23(33)27-18-5-3-9-26-22(18)30/h1-6,9H,7-8,10-16,24H2,(H,25,31)(H,27,33)
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6.65E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M3 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012337
PNG
(5-Ethyl-11-[2-(4-methyl-piperazin-1-yl)-acetyl]-5,...)
Show SMILES CCN1c2cccnc2N(C(=O)CN2CCN(C)CC2)c2ccccc2C1=O
Show InChI InChI=1S/C21H25N5O2/c1-3-25-18-9-6-10-22-20(18)26(17-8-5-4-7-16(17)21(25)28)19(27)15-24-13-11-23(2)12-14-24/h4-10H,3,11-15H2,1-2H3
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7.70E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
The compound was tested for the inhibition of binding of [3H]-N-Methyl-scopolamine to muscarinic acetylcholine receptor M1 of transfected A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50012337
PNG
(5-Ethyl-11-[2-(4-methyl-piperazin-1-yl)-acetyl]-5,...)
Show SMILES CCN1c2cccnc2N(C(=O)CN2CCN(C)CC2)c2ccccc2C1=O
Show InChI InChI=1S/C21H25N5O2/c1-3-25-18-9-6-10-22-20(18)26(17-8-5-4-7-16(17)21(25)28)19(27)15-24-13-11-23(2)12-14-24/h4-10H,3,11-15H2,1-2H3
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8.00E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
The compound was tested for the inhibition of binding of [3H]-N-Methyl-scopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membra...


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50012369
PNG
(4-Acetylamino-N-(2-{4-[2-oxo-2-(6-oxo-5,6-dihydro-...)
Show SMILES CC(=O)NCCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C26H33N7O4/c1-19(34)27-10-5-9-23(35)28-12-13-31-14-16-32(17-15-31)18-24(36)33-22-8-3-2-6-20(22)26(37)30-21-7-4-11-29-25(21)33/h2-4,6-8,11H,5,9-10,12-18H2,1H3,(H,27,34)(H,28,35)(H,30,37)
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8.82E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012374
PNG
(7-{11-[2-(4-Methyl-piperazin-1-yl)-acetyl]-6-oxo-6...)
Show SMILES CN1CCN(CC(=O)N2c3ccccc3C(=O)N(CCCCCCC#N)c3cccnc23)CC1
Show InChI InChI=1S/C26H32N6O2/c1-29-16-18-30(19-17-29)20-24(33)32-22-11-6-5-10-21(22)26(34)31(15-8-4-2-3-7-13-27)23-12-9-14-28-25(23)32/h5-6,9-12,14H,2-4,7-8,15-20H2,1H3
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8.90E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
The compound was tested for the inhibition of binding of [3H]-N-Methyl-scopolamine to muscarinic acetylcholine receptor M1 of transfected A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50012364
PNG
(11-{2-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-acetyl}...)
Show SMILES OCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C20H23N5O3/c26-13-12-23-8-10-24(11-9-23)14-18(27)25-17-6-2-1-4-15(17)20(28)22-16-5-3-7-21-19(16)25/h1-7,26H,8-14H2,(H,22,28)
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9.50E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M3 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012342
PNG
(4-Amino-N-(2-{4-[2-oxo-2-(6-oxo-5,6-dihydro-benzo[...)
Show SMILES NCCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C24H31N7O3/c25-9-3-8-21(32)26-11-12-29-13-15-30(16-14-29)17-22(33)31-20-7-2-1-5-18(20)24(34)28-19-6-4-10-27-23(19)31/h1-2,4-7,10H,3,8-9,11-17,25H2,(H,26,32)(H,28,34)
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9.53E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M1 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012369
PNG
(4-Acetylamino-N-(2-{4-[2-oxo-2-(6-oxo-5,6-dihydro-...)
Show SMILES CC(=O)NCCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C26H33N7O4/c1-19(34)27-10-5-9-23(35)28-12-13-31-14-16-32(17-15-31)18-24(36)33-22-8-3-2-6-20(22)26(37)30-21-7-4-11-29-25(21)33/h2-4,6-8,11H,5,9-10,12-18H2,1H3,(H,27,34)(H,28,35)(H,30,37)
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9.65E+3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M1 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50012369
PNG
(4-Acetylamino-N-(2-{4-[2-oxo-2-(6-oxo-5,6-dihydro-...)
Show SMILES CC(=O)NCCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C26H33N7O4/c1-19(34)27-10-5-9-23(35)28-12-13-31-14-16-32(17-15-31)18-24(36)33-22-8-3-2-6-20(22)26(37)30-21-7-4-11-29-25(21)33/h2-4,6-8,11H,5,9-10,12-18H2,1H3,(H,27,34)(H,28,35)(H,30,37)
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1.08E+4n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M3 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50012352
PNG
(11-[2-(4-Methyl-piperazin-1-yl)-acetyl]-8-methylsu...)
Show SMILES CSc1ccc2N(C(=O)CN3CCN(C)CC3)c3ncccc3NC(=O)c2c1
Show InChI InChI=1S/C20H23N5O2S/c1-23-8-10-24(11-9-23)13-18(26)25-17-6-5-14(28-2)12-15(17)20(27)22-16-4-3-7-21-19(16)25/h3-7,12H,8-11,13H2,1-2H3,(H,22,27)
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1.10E+4n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50012342
PNG
(4-Amino-N-(2-{4-[2-oxo-2-(6-oxo-5,6-dihydro-benzo[...)
Show SMILES NCCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C24H31N7O3/c25-9-3-8-21(32)26-11-12-29-13-15-30(16-14-29)17-22(33)31-20-7-2-1-5-18(20)24(34)28-19-6-4-10-27-23(19)31/h1-2,4-7,10H,3,8-9,11-17,25H2,(H,26,32)(H,28,34)
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1.15E+4n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M3 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012362
PNG
(CHEMBL70133 | [2-(2-{4-[2-Oxo-2-(6-oxo-5,6-dihydro...)
Show SMILES CC(C)(C)OC(=O)NCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C28H37N7O5/c1-28(2,3)40-27(39)31-12-10-23(36)29-13-14-33-15-17-34(18-16-33)19-24(37)35-22-9-5-4-7-20(22)26(38)32-21-8-6-11-30-25(21)35/h4-9,11H,10,12-19H2,1-3H3,(H,29,36)(H,31,39)(H,32,38)
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1.33E+4n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M1 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012334
PNG
((2-{11-[2-(4-Methyl-piperazin-1-yl)-acetyl]-6-oxo-...)
Show SMILES CN1CCN(CC(=O)N2c3ccc(cc3C(=O)Nc3cccnc23)S(=O)(=O)NCCNC(=O)OC(C)(C)C)CC1
Show InChI InChI=1S/C26H35N7O6S/c1-26(2,3)39-25(36)28-10-11-29-40(37,38)18-7-8-21-19(16-18)24(35)30-20-6-5-9-27-23(20)33(21)22(34)17-32-14-12-31(4)13-15-32/h5-9,16,29H,10-15,17H2,1-4H3,(H,28,36)(H,30,35)
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>3.00E+4n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M1 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012361
PNG
(11-[2-(4-Methyl-piperazin-1-yl)-acetyl]-6-oxo-6,11...)
Show SMILES CN1CCN(CC(=O)N2c3ccc(cc3C(=O)Nc3cccnc23)S(=O)(=O)NCCN)CC1
Show InChI InChI=1S/C21H27N7O4S/c1-26-9-11-27(12-10-26)14-19(29)28-18-5-4-15(33(31,32)24-8-6-22)13-16(18)21(30)25-17-3-2-7-23-20(17)28/h2-5,7,13,24H,6,8-12,14,22H2,1H3,(H,25,30)
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>3.00E+4n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M1 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50012356
PNG
(9-(tert-Butyl-dimethyl-silanyloxymethyl)-11-[2-(4-...)
Show SMILES CN1CCN(CC(=O)N2c3cc(CO[Si](C)(C)C(C)(C)C)ccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C26H37N5O3Si/c1-26(2,3)35(5,6)34-18-19-9-10-20-22(16-19)31(23(32)17-30-14-12-29(4)13-15-30)24-21(28-25(20)33)8-7-11-27-24/h7-11,16H,12-15,17-18H2,1-6H3,(H,28,33)
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>3.00E+4n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
The compound was tested for the inhibition of binding of [3H]-N-Methyl-scopolamine to muscarinic acetylcholine receptor M3 of transfected A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50012335
PNG
(11-[2-(4-Methyl-piperazin-1-yl)-acetyl]-6-oxo-6,11...)
Show SMILES CN1CCN(CC(=O)N2c3ccc(cc3C(=O)Nc3cccnc23)S(N)(=O)=O)CC1
Show InChI InChI=1S/C19H22N6O4S/c1-23-7-9-24(10-8-23)12-17(26)25-16-5-4-13(30(20,28)29)11-14(16)19(27)22-15-3-2-6-21-18(15)25/h2-6,11H,7-10,12H2,1H3,(H,22,27)(H2,20,28,29)
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>3.00E+4n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M3 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012367
PNG
(CHEMBL68695 | N-(2-{11-[2-(4-Methyl-piperazin-1-yl...)
Show SMILES CN1CCN(CC(=O)N2c3ccc(cc3C(=O)Nc3cccnc23)S(=O)(=O)NCCNC(C)=O)CC1
Show InChI InChI=1S/C23H29N7O5S/c1-16(31)24-8-9-26-36(34,35)17-5-6-20-18(14-17)23(33)27-19-4-3-7-25-22(19)30(20)21(32)15-29-12-10-28(2)11-13-29/h3-7,14,26H,8-13,15H2,1-2H3,(H,24,31)(H,27,33)
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>3.00E+4n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M1 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012356
PNG
(9-(tert-Butyl-dimethyl-silanyloxymethyl)-11-[2-(4-...)
Show SMILES CN1CCN(CC(=O)N2c3cc(CO[Si](C)(C)C(C)(C)C)ccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C26H37N5O3Si/c1-26(2,3)35(5,6)34-18-19-9-10-20-22(16-19)31(23(32)17-30-14-12-29(4)13-15-30)24-21(28-25(20)33)8-7-11-27-24/h7-11,16H,12-15,17-18H2,1-6H3,(H,28,33)
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>3.00E+4n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
The compound was tested for the inhibition of binding of [3H]-N-Methyl-scopolamine to muscarinic acetylcholine receptor M1r of transfected A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012335
PNG
(11-[2-(4-Methyl-piperazin-1-yl)-acetyl]-6-oxo-6,11...)
Show SMILES CN1CCN(CC(=O)N2c3ccc(cc3C(=O)Nc3cccnc23)S(N)(=O)=O)CC1
Show InChI InChI=1S/C19H22N6O4S/c1-23-7-9-24(10-8-23)12-17(26)25-16-5-4-13(30(20,28)29)11-14(16)19(27)22-15-3-2-6-21-18(15)25/h2-6,11H,7-10,12H2,1H3,(H,22,27)(H2,20,28,29)
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>3.00E+4n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M1 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50012335
PNG
(11-[2-(4-Methyl-piperazin-1-yl)-acetyl]-6-oxo-6,11...)
Show SMILES CN1CCN(CC(=O)N2c3ccc(cc3C(=O)Nc3cccnc23)S(N)(=O)=O)CC1
Show InChI InChI=1S/C19H22N6O4S/c1-23-7-9-24(10-8-23)12-17(26)25-16-5-4-13(30(20,28)29)11-14(16)19(27)22-15-3-2-6-21-18(15)25/h2-6,11H,7-10,12H2,1H3,(H,22,27)(H2,20,28,29)
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>3.00E+4n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50012334
PNG
((2-{11-[2-(4-Methyl-piperazin-1-yl)-acetyl]-6-oxo-...)
Show SMILES CN1CCN(CC(=O)N2c3ccc(cc3C(=O)Nc3cccnc23)S(=O)(=O)NCCNC(=O)OC(C)(C)C)CC1
Show InChI InChI=1S/C26H35N7O6S/c1-26(2,3)39-25(36)28-10-11-29-40(37,38)18-7-8-21-19(16-18)24(35)30-20-6-5-9-27-23(20)33(21)22(34)17-32-14-12-31(4)13-15-32/h5-9,16,29H,10-15,17H2,1-4H3,(H,28,36)(H,30,35)
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>3.00E+4n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M3 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50012367
PNG
(CHEMBL68695 | N-(2-{11-[2-(4-Methyl-piperazin-1-yl...)
Show SMILES CN1CCN(CC(=O)N2c3ccc(cc3C(=O)Nc3cccnc23)S(=O)(=O)NCCNC(C)=O)CC1
Show InChI InChI=1S/C23H29N7O5S/c1-16(31)24-8-9-26-36(34,35)17-5-6-20-18(14-17)23(33)27-19-4-3-7-25-22(19)30(20)21(32)15-29-12-10-28(2)11-13-29/h3-7,14,26H,8-13,15H2,1-2H3,(H,24,31)(H,27,33)
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NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M3 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50012361
PNG
(11-[2-(4-Methyl-piperazin-1-yl)-acetyl]-6-oxo-6,11...)
Show SMILES CN1CCN(CC(=O)N2c3ccc(cc3C(=O)Nc3cccnc23)S(=O)(=O)NCCN)CC1
Show InChI InChI=1S/C21H27N7O4S/c1-26-9-11-27(12-10-26)14-19(29)28-18-5-4-15(33(31,32)24-8-6-22)13-16(18)21(30)25-17-3-2-7-23-20(17)28/h2-5,7,13,24H,6,8-12,14,22H2,1H3,(H,25,30)
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NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M3 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50012358
PNG
(3-Acetylamino-N-(2-{4-[2-oxo-2-(6-oxo-5,6-dihydro-...)
Show SMILES CC(=O)NCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C25H31N7O4/c1-18(33)26-10-8-22(34)27-11-12-30-13-15-31(16-14-30)17-23(35)32-21-7-3-2-5-19(21)25(36)29-20-6-4-9-28-24(20)32/h2-7,9H,8,10-17H2,1H3,(H,26,33)(H,27,34)(H,29,36)
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3.45E+4n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012358
PNG
(3-Acetylamino-N-(2-{4-[2-oxo-2-(6-oxo-5,6-dihydro-...)
Show SMILES CC(=O)NCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C25H31N7O4/c1-18(33)26-10-8-22(34)27-11-12-30-13-15-31(16-14-30)17-23(35)32-21-7-3-2-5-19(21)25(36)29-20-6-4-9-28-24(20)32/h2-7,9H,8,10-17H2,1H3,(H,26,33)(H,27,34)(H,29,36)
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3.94E+4n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M1 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012354
PNG
(11-[2-(4-Acetyl-piperazin-1-yl)-acetyl]-5,11-dihyd...)
Show SMILES CC(=O)N1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C20H21N5O3/c1-14(26)24-11-9-23(10-12-24)13-18(27)25-17-7-3-2-5-15(17)20(28)22-16-6-4-8-21-19(16)25/h2-8H,9-13H2,1H3,(H,22,28)
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NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M1 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(RAT)
BDBM50012333
PNG
(4-[2-Oxo-2-(6-oxo-5,6-dihydro-benzo[e]pyrido[3,2-b...)
Show SMILES O=C(CN1CCN(CC1)C(=S)Nc1ccccc1)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C25H24N6O2S/c32-22(17-29-13-15-30(16-14-29)25(34)27-18-7-2-1-3-8-18)31-21-11-5-4-9-19(21)24(33)28-20-10-6-12-26-23(20)31/h1-12H,13-17H2,(H,27,34)(H,28,33)
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NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-Methyl-scopolamine to muscarinic acetylcholine receptor M4 of rat heart NG108-15 cells


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50012354
PNG
(11-[2-(4-Acetyl-piperazin-1-yl)-acetyl]-5,11-dihyd...)
Show SMILES CC(=O)N1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C20H21N5O3/c1-14(26)24-11-9-23(10-12-24)13-18(27)25-17-7-3-2-5-15(17)20(28)22-16-6-4-8-21-19(16)25/h2-8H,9-13H2,1H3,(H,22,28)
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NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50012330
PNG
(11-[2-(4-Methanesulfonyl-piperazin-1-yl)-acetyl]-5...)
Show SMILES CS(=O)(=O)N1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C19H21N5O4S/c1-29(27,28)23-11-9-22(10-12-23)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)
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NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50012354
PNG
(11-[2-(4-Acetyl-piperazin-1-yl)-acetyl]-5,11-dihyd...)
Show SMILES CC(=O)N1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C20H21N5O3/c1-14(26)24-11-9-23(10-12-24)13-18(27)25-17-7-3-2-5-15(17)20(28)22-16-6-4-8-21-19(16)25/h2-8H,9-13H2,1H3,(H,22,28)
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NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M3 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012329
PNG
(11-[2-(4-Benzoyl-piperazin-1-yl)-acetyl]-5,11-dihy...)
Show SMILES O=C(CN1CCN(CC1)C(=O)c1ccccc1)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C25H23N5O3/c31-22(17-28-13-15-29(16-14-28)25(33)18-7-2-1-3-8-18)30-21-11-5-4-9-19(21)24(32)27-20-10-6-12-26-23(20)30/h1-12H,13-17H2,(H,27,32)
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NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M1 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50012330
PNG
(11-[2-(4-Methanesulfonyl-piperazin-1-yl)-acetyl]-5...)
Show SMILES CS(=O)(=O)N1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C19H21N5O4S/c1-29(27,28)23-11-9-22(10-12-23)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)
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NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M3 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(RAT)
BDBM50012330
PNG
(11-[2-(4-Methanesulfonyl-piperazin-1-yl)-acetyl]-5...)
Show SMILES CS(=O)(=O)N1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C19H21N5O4S/c1-29(27,28)23-11-9-22(10-12-23)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)
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NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-Methyl-scopolamine to muscarinic acetylcholine receptor M4 of rat heart NG108-15 cells


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012330
PNG
(11-[2-(4-Methanesulfonyl-piperazin-1-yl)-acetyl]-5...)
Show SMILES CS(=O)(=O)N1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C19H21N5O4S/c1-29(27,28)23-11-9-22(10-12-23)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)
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NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M1 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50012358
PNG
(3-Acetylamino-N-(2-{4-[2-oxo-2-(6-oxo-5,6-dihydro-...)
Show SMILES CC(=O)NCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C25H31N7O4/c1-18(33)26-10-8-22(34)27-11-12-30-13-15-31(16-14-30)17-23(35)32-21-7-3-2-5-19(21)25(36)29-20-6-4-9-28-24(20)32/h2-7,9H,8,10-17H2,1H3,(H,26,33)(H,27,34)(H,29,36)
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NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M3 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50012333
PNG
(4-[2-Oxo-2-(6-oxo-5,6-dihydro-benzo[e]pyrido[3,2-b...)
Show SMILES O=C(CN1CCN(CC1)C(=S)Nc1ccccc1)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C25H24N6O2S/c32-22(17-29-13-15-30(16-14-29)25(34)27-18-7-2-1-3-8-18)31-21-11-5-4-9-19(21)24(33)28-20-10-6-12-26-23(20)31/h1-12H,13-17H2,(H,27,34)(H,28,33)
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NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M3 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50012333
PNG
(4-[2-Oxo-2-(6-oxo-5,6-dihydro-benzo[e]pyrido[3,2-b...)
Show SMILES O=C(CN1CCN(CC1)C(=S)Nc1ccccc1)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C25H24N6O2S/c32-22(17-29-13-15-30(16-14-29)25(34)27-18-7-2-1-3-8-18)31-21-11-5-4-9-19(21)24(33)28-20-10-6-12-26-23(20)31/h1-12H,13-17H2,(H,27,34)(H,28,33)
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NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M1 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50012329
PNG
(11-[2-(4-Benzoyl-piperazin-1-yl)-acetyl]-5,11-dihy...)
Show SMILES O=C(CN1CCN(CC1)C(=O)c1ccccc1)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C25H23N5O3/c31-22(17-28-13-15-29(16-14-28)25(33)18-7-2-1-3-8-18)30-21-11-5-4-9-19(21)24(32)27-20-10-6-12-26-23(20)30/h1-12H,13-17H2,(H,27,32)
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NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(RAT)
BDBM50012329
PNG
(11-[2-(4-Benzoyl-piperazin-1-yl)-acetyl]-5,11-dihy...)
Show SMILES O=C(CN1CCN(CC1)C(=O)c1ccccc1)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C25H23N5O3/c31-22(17-28-13-15-29(16-14-28)25(33)18-7-2-1-3-8-18)30-21-11-5-4-9-19(21)24(32)27-20-10-6-12-26-23(20)30/h1-12H,13-17H2,(H,27,32)
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NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-Methyl-scopolamine to muscarinic acetylcholine receptor M4 of rat heart NG108-15 cells


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50012329
PNG
(11-[2-(4-Benzoyl-piperazin-1-yl)-acetyl]-5,11-dihy...)
Show SMILES O=C(CN1CCN(CC1)C(=O)c1ccccc1)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C25H23N5O3/c31-22(17-28-13-15-29(16-14-28)25(33)18-7-2-1-3-8-18)30-21-11-5-4-9-19(21)24(32)27-20-10-6-12-26-23(20)30/h1-12H,13-17H2,(H,27,32)
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UniChem

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>1.00E+5n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M3 of transfected rat A9L cells.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(RAT)
BDBM50012354
PNG
(11-[2-(4-Acetyl-piperazin-1-yl)-acetyl]-5,11-dihyd...)
Show SMILES CC(=O)N1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C20H21N5O3/c1-14(26)24-11-9-23(10-12-24)13-18(27)25-17-7-3-2-5-15(17)20(28)22-16-6-4-8-21-19(16)25/h2-8H,9-13H2,1H3,(H,22,28)
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PC cid
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UniChem

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PubMed
>1.00E+5n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-Methyl-scopolamine to muscarinic acetylcholine receptor M4 of rat heart NG108-15 cells


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50012333
PNG
(4-[2-Oxo-2-(6-oxo-5,6-dihydro-benzo[e]pyrido[3,2-b...)
Show SMILES O=C(CN1CCN(CC1)C(=S)Nc1ccccc1)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C25H24N6O2S/c32-22(17-29-13-15-30(16-14-29)25(34)27-18-7-2-1-3-8-18)31-21-11-5-4-9-19(21)24(33)28-20-10-6-12-26-23(20)31/h1-12H,13-17H2,(H,27,34)(H,28,33)
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PC cid
PC sid
UniChem

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PubMed
>1.00E+5n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.


J Med Chem 34: 2133-45 (1991)


BindingDB Entry DOI: 10.7270/Q2SJ1JKW
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%