Found 12 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50326268
(CHEMBL1240773)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(N)=O |r,wU:125.127,111.118,103.105,133.137,88.89,136.140,74.79,142.145,154.157,42.43,28.34,8.16,2.2,169.174,188.194,203.209,216.222,wD:120.122,92.101,82.85,70.71,148.151,60.60,47.53,37.38,19.25,4.4,174.178,196.202,(-13.87,-31.33,;-13.87,-29.78,;-12.55,-29.02,;-11.21,-29.78,;-12.55,-27.48,;-13.87,-26.7,;-15.2,-27.47,;-15.2,-29.01,;-16.53,-26.7,;-16.53,-25.16,;-15.2,-24.4,;-13.88,-25.16,;-12.55,-24.4,;-12.55,-22.85,;-13.88,-22.09,;-15.2,-22.86,;-17.87,-27.47,;-19.2,-26.7,;-19.2,-25.16,;-20.54,-27.47,;-20.54,-29.01,;-19.2,-29.77,;-19.2,-31.31,;-20.53,-32.09,;-17.88,-32.08,;-21.86,-26.69,;-23.21,-27.46,;-23.21,-29.01,;-24.53,-26.69,;-24.53,-25.15,;-23.21,-24.38,;-23.21,-22.84,;-21.85,-22.08,;-21.85,-20.54,;-25.86,-27.46,;-27.21,-26.69,;-27.21,-25.15,;-28.53,-27.46,;-28.53,-29,;-29.86,-26.68,;-31.2,-27.46,;-31.2,-29,;-32.53,-26.68,;-32.53,-25.15,;-33.86,-27.45,;-35.2,-26.68,;-35.2,-25.14,;-36.52,-27.44,;-36.52,-28.99,;-35.2,-29.75,;-35.2,-31.3,;-36.53,-32.07,;-33.86,-32.07,;-37.87,-26.67,;-39.19,-27.44,;-39.19,-28.99,;-40.52,-26.67,;-41.86,-27.44,;-43.19,-26.67,;-43.19,-25.13,;-44.53,-27.43,;-44.53,-28.98,;-43.19,-29.75,;-43.19,-31.29,;-44.52,-32.05,;-57.87,-32.04,;-59.19,-31.26,;-60.52,-32.02,;-59.18,-29.73,;-60.51,-28.96,;-60.51,-27.42,;-61.85,-26.65,;-63.18,-27.41,;-63.18,-28.95,;-64.51,-26.65,;-64.51,-25.1,;-63.18,-24.34,;-61.84,-25.1,;-63.18,-22.8,;-65.84,-27.41,;-67.18,-26.64,;-67.18,-25.1,;-68.51,-27.41,;-68.51,-28.95,;-67.18,-29.72,;-69.85,-26.63,;-71.17,-27.4,;-71.17,-28.95,;-72.51,-26.63,;-73.84,-27.4,;-75.18,-26.63,;-75.18,-25.09,;-76.51,-27.4,;-76.51,-28.94,;-75.18,-29.71,;-73.86,-28.95,;-72.52,-29.72,;-72.53,-31.26,;-73.87,-32.02,;-75.18,-31.25,;-77.84,-26.62,;-79.17,-27.4,;-79.17,-28.94,;-80.51,-26.62,;-81.84,-27.39,;-83.17,-26.62,;-83.17,-25.08,;-84.5,-27.39,;-85.84,-26.62,;-87.17,-27.39,;-87.17,-28.93,;-88.51,-26.61,;-88.51,-25.08,;-87.17,-24.3,;-87.17,-22.77,;-88.5,-22,;-85.83,-22,;-89.84,-27.38,;-91.17,-26.61,;-91.17,-25.07,;-92.5,-27.38,;-92.5,-28.92,;-93.84,-26.61,;-95.17,-27.38,;-95.17,-28.92,;-96.5,-26.61,;-97.83,-27.38,;-96.5,-25.07,;-95.17,-24.29,;-93.76,-24.93,;-92.73,-23.79,;-93.49,-22.45,;-95,-22.77,;-80.51,-25.09,;-81.84,-24.32,;-79.17,-24.32,;-72.51,-25.09,;-73.84,-24.33,;-71.17,-24.33,;-59.18,-26.65,;-59.18,-25.12,;-57.85,-27.42,;-56.51,-26.65,;-56.51,-25.12,;-55.18,-24.34,;-55.18,-27.42,;-55.18,-28.96,;-53.85,-26.66,;-52.52,-27.42,;-52.52,-28.97,;-51.18,-29.74,;-51.18,-26.66,;-51.18,-25.13,;-49.85,-27.43,;-48.52,-26.66,;-48.52,-25.13,;-47.2,-24.35,;-45.87,-25.13,;-44.54,-24.35,;-44.53,-22.81,;-43.2,-22.04,;-45.88,-22.04,;-47.2,-22.82,;-47.2,-27.43,;-47.2,-28.97,;-45.86,-26.67,;-11.21,-26.7,;-11.21,-25.17,;-9.86,-27.48,;-8.53,-26.71,;-8.53,-25.17,;-7.19,-27.48,;-7.19,-29.02,;-5.87,-26.71,;-4.53,-27.48,;-4.53,-29.02,;-3.2,-29.8,;-1.8,-29.17,;-.78,-30.32,;-1.55,-31.65,;-1.07,-33.12,;-2.1,-34.26,;-3.62,-33.94,;-4.08,-32.47,;-3.05,-31.33,;-3.2,-26.71,;-3.2,-25.18,;-1.86,-27.49,;-.54,-26.72,;-.54,-25.18,;.8,-24.41,;.8,-22.88,;2.14,-25.18,;.8,-27.49,;.8,-29.03,;2.14,-26.72,;3.47,-27.49,;3.47,-29.03,;4.8,-29.81,;2.14,-29.81,;4.8,-26.72,;4.8,-25.19,;6.13,-27.5,;7.47,-26.73,;7.47,-25.19,;8.8,-24.42,;8.8,-22.89,;10.14,-22.11,;10.14,-20.58,;8.8,-27.5,;8.8,-29.04,;10.13,-26.73,;11.46,-27.5,;12.8,-26.74,;12.8,-25.2,;14.13,-27.5,;15.46,-26.74,;15.46,-25.2,;16.8,-24.43,;16.8,-22.89,;18.13,-22.12,;18.13,-20.58,;16.81,-19.82,;19.47,-19.82,;16.8,-27.51,;18.13,-26.74,;16.8,-29.05,)| Show InChI InChI=1S/C144H216N40O43/c1-13-73(6)115(141(225)163-77(10)122(206)172-101(59-83-62-155-88-34-21-20-33-86(83)88)132(216)173-97(55-71(2)3)134(218)182-114(72(4)5)140(224)171-91(35-22-25-51-145)125(209)156-64-108(193)164-89(118(149)202)38-28-54-154-144(150)151)183-135(219)99(56-80-29-16-14-17-30-80)174-129(213)96(46-50-112(198)199)169-128(212)92(36-23-26-52-146)166-120(204)75(8)160-119(203)74(7)162-127(211)94(43-47-106(148)191)165-109(194)65-157-124(208)90-37-24-27-53-153-107(192)48-44-95(130(214)178-104(68-186)139(223)179-103(67-185)137(221)175-98(131(215)168-90)58-82-39-41-85(190)42-40-82)170-133(217)102(61-113(200)201)176-138(222)105(69-187)180-143(227)117(79(12)189)184-136(220)100(57-81-31-18-15-19-32-81)177-142(226)116(78(11)188)181-110(195)66-158-126(210)93(45-49-111(196)197)167-121(205)76(9)161-123(207)87(147)60-84-63-152-70-159-84/h14-21,29-34,39-42,62-63,70-79,87,89-105,114-117,155,185-190H,13,22-28,35-38,43-61,64-69,145-147H2,1-12H3,(H2,148,191)(H2,149,202)(H,152,159)(H,153,192)(H,156,209)(H,157,208)(H,158,210)(H,160,203)(H,161,207)(H,162,211)(H,163,225)(H,164,193)(H,165,194)(H,166,204)(H,167,205)(H,168,215)(H,169,212)(H,170,217)(H,171,224)(H,172,206)(H,173,216)(H,174,213)(H,175,221)(H,176,222)(H,177,226)(H,178,214)(H,179,223)(H,180,227)(H,181,195)(H,182,218)(H,183,219)(H,184,220)(H,196,197)(H,198,199)(H,200,201)(H4,150,151,154)/t73-,74-,75-,76-,77-,78+,79+,87-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,114-,115-,116-,117-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 4 | n/a | n/a | n/a | n/a |
University of Texas at Dallas
Curated by ChEMBL
| Assay Description
Activation of human GLP1 receptor expressed in HEK293 cells assessed as increase in cAMP accumulation |
J Med Chem 53: 6412-20 (2010)
Article DOI: 10.1021/jm100602m
BindingDB Entry DOI: 10.7270/Q200029G |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50326269
(CHEMBL1240774)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(N)=O |r,wU:122.124,108.115,100.102,130.134,85.86,133.137,71.76,61.64,142.145,42.43,28.34,8.16,2.2,169.174,188.194,203.209,216.222,wD:117.119,89.98,79.82,67.68,57.58,154.158,47.47,37.38,19.25,4.4,174.178,196.202,(84.76,-36.24,;84.76,-34.69,;86.09,-33.93,;87.43,-34.69,;86.09,-32.38,;84.76,-31.61,;83.43,-32.38,;83.43,-33.92,;82.09,-31.6,;82.09,-30.07,;83.43,-29.3,;84.75,-30.07,;86.08,-29.3,;86.08,-27.75,;84.75,-26.99,;83.42,-27.76,;80.76,-32.38,;79.43,-31.6,;79.43,-30.06,;78.09,-32.37,;78.09,-33.92,;79.43,-34.68,;79.43,-36.22,;78.08,-37,;80.75,-37,;76.76,-31.6,;75.42,-32.37,;75.42,-33.91,;74.09,-31.6,;74.09,-30.06,;75.42,-29.28,;75.42,-27.75,;76.76,-26.98,;76.76,-25.44,;72.75,-32.37,;71.41,-31.59,;71.41,-30.06,;70.09,-32.37,;70.09,-33.91,;68.75,-31.59,;67.42,-32.36,;67.42,-33.91,;66.08,-31.59,;66.08,-30.05,;64.75,-32.36,;63.41,-31.58,;63.41,-30.05,;62.08,-32.35,;62.08,-33.9,;63.41,-34.66,;63.41,-36.21,;62.09,-36.97,;48.73,-36.94,;47.41,-36.17,;46.08,-36.94,;47.41,-34.64,;46.08,-33.87,;46.08,-32.33,;44.75,-31.56,;43.41,-32.33,;43.41,-33.87,;42.08,-31.56,;42.08,-30.02,;43.41,-29.25,;40.74,-32.33,;39.4,-31.56,;39.4,-30.02,;38.08,-32.32,;36.73,-31.56,;35.41,-32.32,;35.41,-33.86,;34.07,-31.55,;34.07,-30.01,;35.41,-29.24,;36.74,-30.01,;35.41,-27.7,;32.74,-32.32,;31.4,-31.54,;31.4,-30.01,;30.07,-32.31,;30.07,-33.86,;31.4,-34.63,;28.73,-31.54,;27.41,-32.31,;27.41,-33.85,;26.06,-31.54,;24.74,-32.31,;23.4,-31.53,;23.4,-30,;22.06,-32.31,;22.06,-33.85,;23.4,-34.62,;24.72,-33.85,;26.06,-34.63,;26.05,-36.17,;24.71,-36.93,;23.4,-36.16,;20.73,-31.53,;19.39,-32.3,;19.39,-33.85,;18.06,-31.53,;16.72,-32.3,;15.39,-31.53,;15.39,-29.99,;14.06,-32.3,;12.74,-31.52,;11.39,-32.29,;11.39,-33.84,;10.06,-31.52,;10.06,-29.98,;11.39,-29.21,;11.39,-27.67,;10.05,-26.91,;12.73,-26.9,;8.72,-32.29,;7.39,-31.52,;7.39,-29.98,;6.05,-32.29,;6.05,-33.83,;4.71,-31.52,;3.38,-32.29,;3.38,-33.83,;2.06,-31.52,;.72,-32.29,;2.06,-29.97,;3.4,-29.2,;4.8,-29.83,;5.83,-28.69,;5.07,-27.35,;3.55,-27.67,;18.06,-29.99,;16.72,-29.23,;19.39,-29.22,;26.06,-30,;24.74,-29.24,;27.41,-29.23,;38.08,-33.87,;39.4,-34.64,;36.73,-34.64,;47.42,-31.57,;47.42,-30.03,;48.75,-32.33,;50.08,-31.57,;50.08,-30.03,;51.41,-29.26,;52.73,-30.03,;54.06,-29.26,;54.06,-27.72,;55.4,-26.94,;52.73,-26.95,;51.41,-27.72,;51.41,-32.34,;51.41,-33.88,;52.74,-31.57,;54.07,-32.34,;54.07,-33.89,;55.41,-34.66,;55.41,-36.2,;56.74,-33.89,;55.41,-31.58,;55.41,-30.04,;56.74,-32.34,;58.08,-31.58,;59.42,-32.35,;59.42,-33.9,;60.74,-31.58,;87.43,-31.61,;87.43,-30.07,;88.77,-32.39,;90.1,-31.61,;90.1,-30.08,;91.44,-32.39,;91.44,-33.93,;92.76,-31.62,;94.1,-32.39,;94.1,-33.93,;95.43,-34.71,;96.83,-34.08,;97.85,-35.23,;97.09,-36.57,;97.57,-38.03,;96.53,-39.17,;95.02,-38.85,;94.55,-37.38,;95.59,-36.24,;95.43,-31.62,;95.43,-30.08,;96.77,-32.39,;98.1,-31.62,;98.1,-30.08,;99.44,-29.32,;99.44,-27.78,;100.78,-30.08,;99.44,-32.4,;99.44,-33.94,;100.77,-31.62,;102.11,-32.4,;102.11,-33.94,;103.44,-34.71,;100.77,-34.72,;103.44,-31.63,;103.44,-30.09,;104.77,-32.4,;106.11,-31.64,;106.11,-30.09,;107.44,-29.33,;107.44,-27.79,;108.78,-27.01,;108.78,-25.48,;107.44,-32.41,;107.44,-33.95,;108.78,-31.64,;110.11,-32.41,;111.44,-31.64,;111.44,-30.11,;112.78,-32.41,;114.11,-31.65,;114.11,-30.11,;115.45,-29.33,;115.45,-27.8,;116.78,-27.02,;116.78,-25.49,;115.46,-24.72,;118.12,-24.72,;115.45,-32.41,;116.79,-31.65,;115.45,-33.96,)| Show InChI InChI=1S/C147H223N39O41/c1-17-77(10)118(144(225)165-81(14)125(206)173-105(62-87-65-157-92-38-25-24-37-90(87)92)135(216)175-101(58-74(4)5)136(217)183-116(75(6)7)142(223)172-94(39-26-29-53-148)127(208)158-67-110(193)166-93(121(151)202)42-32-56-156-147(152)153)185-137(218)103(59-84-33-20-18-21-34-84)177-133(214)99(49-52-114(198)199)170-131(212)96(40-27-30-54-149)168-123(204)79(12)162-122(203)78(11)164-130(211)95-41-28-31-55-155-109(192)50-47-98(132(213)176-102(61-86-43-45-89(191)46-44-86)134(215)174-100(57-73(2)3)129(210)160-68-111(194)167-95)171-140(221)107(70-187)180-143(224)117(76(8)9)184-139(220)106(64-115(200)201)178-141(222)108(71-188)181-146(227)120(83(16)190)186-138(219)104(60-85-35-22-19-23-36-85)179-145(226)119(82(15)189)182-112(195)69-159-128(209)97(48-51-113(196)197)169-124(205)80(13)163-126(207)91(150)63-88-66-154-72-161-88/h18-25,33-38,43-46,65-66,72-83,91,93-108,116-120,157,187-191H,17,26-32,39-42,47-64,67-71,148-150H2,1-16H3,(H2,151,202)(H,154,161)(H,155,192)(H,158,208)(H,159,209)(H,160,210)(H,162,203)(H,163,207)(H,164,211)(H,165,225)(H,166,193)(H,167,194)(H,168,204)(H,169,205)(H,170,212)(H,171,221)(H,172,223)(H,173,206)(H,174,215)(H,175,216)(H,176,213)(H,177,214)(H,178,222)(H,179,226)(H,180,224)(H,181,227)(H,182,195)(H,183,217)(H,184,220)(H,185,218)(H,186,219)(H,196,197)(H,198,199)(H,200,201)(H4,152,153,156)/t77-,78-,79-,80-,81-,82+,83+,91-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,116-,117-,118-,119-,120-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.631 | n/a | n/a | n/a | n/a |
University of Texas at Dallas
Curated by ChEMBL
| Assay Description
Activation of human GLP1 receptor expressed in HEK293 cells assessed as increase in cAMP accumulation |
J Med Chem 53: 6412-20 (2010)
Article DOI: 10.1021/jm100602m
BindingDB Entry DOI: 10.7270/Q200029G |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50326270
(CHEMBL1240775)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O |r| Show InChI InChI=1S/C152H227N39O47/c1-17-77(10)121(148(234)168-81(14)127(213)177-106(62-87-65-161-92-36-25-24-35-90(87)92)138(224)179-102(58-74(4)5)139(225)188-119(75(6)7)146(232)176-93(37-26-28-54-153)129(215)162-67-113(200)169-100(151(237)238)39-30-56-160-152(156)157)190-140(226)104(59-84-31-20-18-21-32-84)180-135(221)99(48-53-117(206)207)174-132(218)94-38-27-29-55-159-112(199)50-45-97(133(219)172-96(44-49-111(155)198)131(217)167-78(11)124(210)165-79(12)125(211)170-94)173-134(220)98(47-52-116(204)205)175-136(222)101(57-73(2)3)178-137(223)103(61-86-40-42-89(197)43-41-86)181-143(229)108(69-192)184-145(231)110(71-194)185-147(233)120(76(8)9)189-142(228)107(64-118(208)209)182-144(230)109(70-193)186-150(236)123(83(16)196)191-141(227)105(60-85-33-22-19-23-34-85)183-149(235)122(82(15)195)187-114(201)68-163-130(216)95(46-51-115(202)203)171-126(212)80(13)166-128(214)91(154)63-88-66-158-72-164-88/h18-25,31-36,40-43,65-66,72-83,91,93-110,119-123,161,192-197H,17,26-30,37-39,44-64,67-71,153-154H2,1-16H3,(H2,155,198)(H,158,164)(H,159,199)(H,162,215)(H,163,216)(H,165,210)(H,166,214)(H,167,217)(H,168,234)(H,169,200)(H,170,211)(H,171,212)(H,172,219)(H,173,220)(H,174,218)(H,175,222)(H,176,232)(H,177,213)(H,178,223)(H,179,224)(H,180,221)(H,181,229)(H,182,230)(H,183,235)(H,184,231)(H,185,233)(H,186,236)(H,187,201)(H,188,225)(H,189,228)(H,190,226)(H,191,227)(H,202,203)(H,204,205)(H,206,207)(H,208,209)(H,237,238)(H4,156,157,160)/t77-,78-,79-,80-,81-,82+,83+,91-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,119-,120-,121-,122-,123-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.80 | n/a | n/a | n/a | n/a |
University of Texas at Dallas
Curated by ChEMBL
| Assay Description
Activation of human GLP1 receptor expressed in HEK293 cells assessed as increase in cAMP accumulation |
J Med Chem 53: 6412-20 (2010)
Article DOI: 10.1021/jm100602m
BindingDB Entry DOI: 10.7270/Q200029G |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50326274
(CHEMBL1240781)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O |r| Show InChI InChI=1S/C154H228N40O47/c1-16-78(10)123(151(239)179-99-45-51-114(203)161-55-27-25-36-94(131(219)165-68-115(204)171-93(126(157)214)38-29-57-163-154(158)159)178-149(237)121(76(6)7)191-142(230)103(59-75(4)5)181-141(229)107(184-137(99)225)63-87-66-164-92-35-24-23-34-90(87)92)193-143(231)105(60-84-30-19-17-20-31-84)182-138(226)101(48-54-119(210)211)176-134(222)95-37-26-28-56-162-113(202)50-44-98(135(223)174-97(43-49-112(156)201)133(221)170-79(11)127(215)168-80(12)128(216)172-95)175-136(224)100(47-53-118(208)209)177-139(227)102(58-74(2)3)180-140(228)104(62-86-39-41-89(200)42-40-86)183-146(234)109(70-195)187-148(236)111(72-197)188-150(238)122(77(8)9)192-145(233)108(65-120(212)213)185-147(235)110(71-196)189-153(241)125(83(15)199)194-144(232)106(61-85-32-21-18-22-33-85)186-152(240)124(82(14)198)190-116(205)69-166-132(220)96(46-52-117(206)207)173-129(217)81(13)169-130(218)91(155)64-88-67-160-73-167-88/h17-24,30-35,39-42,66-67,73-83,91,93-111,121-125,164,195-200H,16,25-29,36-38,43-65,68-72,155H2,1-15H3,(H2,156,201)(H2,157,214)(H,160,167)(H,161,203)(H,162,202)(H,165,219)(H,166,220)(H,168,215)(H,169,218)(H,170,221)(H,171,204)(H,172,216)(H,173,217)(H,174,223)(H,175,224)(H,176,222)(H,177,227)(H,178,237)(H,179,239)(H,180,228)(H,181,229)(H,182,226)(H,183,234)(H,184,225)(H,185,235)(H,186,240)(H,187,236)(H,188,238)(H,189,241)(H,190,205)(H,191,230)(H,192,233)(H,193,231)(H,194,232)(H,206,207)(H,208,209)(H,210,211)(H,212,213)(H4,158,159,163)/t78-,79-,80-,81-,82+,83+,91-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,121-,122-,123-,124-,125-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a |
University of Texas at Dallas
Curated by ChEMBL
| Assay Description
Activation of human GLP1 receptor expressed in HEK293 cells assessed as increase in cAMP accumulation |
J Med Chem 53: 6412-20 (2010)
Article DOI: 10.1021/jm100602m
BindingDB Entry DOI: 10.7270/Q200029G |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50326273
(CHEMBL1240780)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N1)C(=O)N[C@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O |r| Show InChI InChI=1S/C157H235N41O46/c1-16-81(10)126(154(242)183-99-40-27-30-60-165-116(205)53-47-100(134(222)169-72-118(207)175-96(129(161)217)41-31-61-167-157(162)163)184-152(240)124(79(6)7)195-146(234)107(63-78(4)5)186-145(233)111(189-139(99)227)67-90-70-168-95-37-24-23-36-93(90)95)197-147(235)109(64-87-32-19-17-20-33-87)188-142(230)105(51-57-122(213)214)181-137(225)97(38-25-28-58-158)176-131(219)83(12)172-130(218)82(11)174-136(224)102(46-52-115(160)204)179-140(228)103-48-54-117(206)166-59-29-26-39-98(138(226)187-108(66-89-42-44-92(203)45-43-89)144(232)185-106(62-77(2)3)143(231)182-104(141(229)180-103)50-56-121(211)212)178-150(238)113(74-199)192-153(241)125(80(8)9)196-149(237)112(69-123(215)216)190-151(239)114(75-200)193-156(244)128(86(15)202)198-148(236)110(65-88-34-21-18-22-35-88)191-155(243)127(85(14)201)194-119(208)73-170-135(223)101(49-55-120(209)210)177-132(220)84(13)173-133(221)94(159)68-91-71-164-76-171-91/h17-24,32-37,42-45,70-71,76-86,94,96-114,124-128,168,199-203H,16,25-31,38-41,46-69,72-75,158-159H2,1-15H3,(H2,160,204)(H2,161,217)(H,164,171)(H,165,205)(H,166,206)(H,169,222)(H,170,223)(H,172,218)(H,173,221)(H,174,224)(H,175,207)(H,176,219)(H,177,220)(H,178,238)(H,179,228)(H,180,229)(H,181,225)(H,182,231)(H,183,242)(H,184,240)(H,185,232)(H,186,233)(H,187,226)(H,188,230)(H,189,227)(H,190,239)(H,191,243)(H,192,241)(H,193,244)(H,194,208)(H,195,234)(H,196,237)(H,197,235)(H,198,236)(H,209,210)(H,211,212)(H,213,214)(H,215,216)(H4,162,163,167)/t81-,82-,83-,84-,85+,86+,94-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,124-,125-,126-,127-,128-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1 | n/a | n/a | n/a | n/a |
University of Texas at Dallas
Curated by ChEMBL
| Assay Description
Activation of human GLP1 receptor expressed in HEK293 cells assessed as increase in cAMP accumulation |
J Med Chem 53: 6412-20 (2010)
Article DOI: 10.1021/jm100602m
BindingDB Entry DOI: 10.7270/Q200029G |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50326267
(CHEMBL1240772)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(O)=O |r,wU:147.150,133.141,125.128,155.160,110.112,158.163,96.102,86.90,68.78,42.43,28.34,8.16,2.2,167.171,186.191,201.206,214.219,wD:142.145,114.124,104.108,92.94,80.84,60.65,47.53,37.38,19.25,4.4,172.175,194.199,(-6.48,-33.2,;-6.48,-31.65,;-5.15,-30.89,;-3.81,-31.65,;-5.15,-29.34,;-6.48,-28.57,;-7.81,-29.34,;-7.81,-30.88,;-9.14,-28.57,;-9.14,-27.03,;-7.81,-26.26,;-6.49,-27.03,;-5.16,-26.26,;-5.16,-24.72,;-6.49,-23.95,;-7.81,-24.73,;-10.48,-29.34,;-11.81,-28.56,;-11.81,-27.03,;-13.15,-29.34,;-13.15,-30.88,;-11.81,-31.64,;-11.81,-33.18,;-13.15,-33.96,;-10.48,-33.95,;-14.48,-28.56,;-15.82,-29.33,;-15.82,-30.87,;-17.15,-28.56,;-17.15,-27.02,;-15.82,-26.25,;-15.82,-24.71,;-14.47,-23.95,;-14.47,-22.41,;-18.48,-29.33,;-19.83,-28.56,;-19.83,-27.02,;-21.14,-29.33,;-21.14,-30.87,;-22.48,-28.55,;-23.81,-29.32,;-23.81,-30.87,;-25.15,-28.55,;-25.15,-27.01,;-26.48,-29.32,;-27.82,-28.55,;-27.82,-27.01,;-29.13,-29.31,;-29.13,-30.86,;-27.82,-31.62,;-27.82,-33.16,;-29.14,-33.94,;-26.48,-33.94,;-30.49,-28.54,;-31.8,-29.31,;-31.8,-30.86,;-33.14,-28.54,;-34.48,-29.3,;-35.81,-28.54,;-35.81,-27,;-37.15,-29.3,;-37.15,-30.85,;-35.81,-31.61,;-35.81,-33.16,;-34.49,-30.85,;-38.48,-28.54,;-39.82,-29.3,;-39.82,-30.84,;-41.13,-28.53,;-41.13,-27,;-39.82,-26.22,;-38.48,-27,;-37.15,-26.22,;-37.15,-24.68,;-35.81,-23.91,;-38.49,-23.91,;-39.82,-24.69,;-42.47,-29.3,;-43.8,-28.53,;-43.8,-26.99,;-45.13,-29.29,;-45.13,-30.83,;-43.8,-31.61,;-46.46,-28.53,;-47.8,-29.29,;-47.8,-30.83,;-49.13,-28.52,;-49.13,-26.99,;-47.8,-26.21,;-50.46,-29.29,;-51.8,-28.52,;-51.8,-26.99,;-53.13,-29.28,;-54.46,-28.52,;-55.79,-29.28,;-55.79,-30.82,;-57.13,-28.52,;-57.13,-26.97,;-55.79,-26.21,;-54.46,-26.97,;-55.79,-24.67,;-58.46,-29.28,;-59.79,-28.5,;-59.79,-26.97,;-61.12,-29.28,;-61.12,-30.82,;-59.79,-31.59,;-62.46,-28.5,;-63.79,-29.27,;-63.79,-30.81,;-65.12,-28.5,;-66.45,-29.27,;-67.79,-28.5,;-67.79,-26.96,;-69.12,-29.27,;-69.12,-30.81,;-67.79,-31.58,;-66.47,-30.81,;-65.14,-31.59,;-65.14,-33.13,;-66.48,-33.89,;-67.8,-33.12,;-70.45,-28.49,;-71.79,-29.26,;-71.79,-30.81,;-73.12,-28.49,;-74.45,-29.26,;-75.78,-28.49,;-75.78,-26.95,;-77.12,-29.26,;-78.45,-28.48,;-79.78,-29.26,;-79.78,-30.8,;-81.12,-28.48,;-81.12,-26.95,;-79.78,-26.17,;-79.78,-24.64,;-81.12,-23.87,;-78.44,-23.87,;-82.45,-29.25,;-83.79,-28.48,;-83.79,-26.94,;-85.11,-29.25,;-85.11,-30.79,;-86.45,-28.48,;-87.78,-29.25,;-87.78,-30.79,;-89.12,-28.48,;-90.44,-29.25,;-89.12,-26.94,;-87.78,-26.16,;-86.37,-26.8,;-85.34,-25.65,;-86.1,-24.32,;-87.61,-24.64,;-73.12,-26.95,;-74.45,-26.19,;-71.79,-26.19,;-65.12,-26.96,;-66.45,-26.2,;-63.79,-26.2,;-53.13,-30.83,;-51.8,-31.6,;-54.46,-31.6,;-3.81,-28.57,;-3.81,-27.04,;-2.48,-29.35,;-1.15,-28.58,;-1.15,-27.04,;.19,-29.35,;.19,-30.89,;1.52,-28.58,;2.85,-29.35,;2.85,-30.89,;4.18,-31.67,;5.58,-31.04,;6.6,-32.19,;5.84,-33.52,;6.31,-34.99,;5.28,-36.13,;3.77,-35.81,;3.3,-34.34,;4.34,-33.2,;4.18,-28.58,;4.18,-27.05,;5.52,-29.36,;6.85,-28.58,;6.85,-27.05,;8.18,-26.28,;8.18,-24.75,;9.52,-27.05,;8.18,-29.36,;8.18,-30.9,;9.52,-28.59,;10.85,-29.36,;10.85,-30.9,;12.18,-31.67,;9.52,-31.68,;12.18,-28.59,;12.18,-27.05,;13.51,-29.36,;14.85,-28.6,;14.85,-27.06,;16.18,-26.29,;16.18,-24.76,;17.52,-23.98,;17.52,-22.45,;16.18,-29.37,;16.18,-30.91,;17.51,-28.6,;18.84,-29.37,;20.18,-28.61,;20.18,-27.07,;21.51,-29.37,;22.84,-28.61,;22.84,-27.07,;24.18,-26.3,;24.18,-24.76,;25.51,-23.99,;25.51,-22.45,;24.19,-21.69,;26.85,-21.69,;24.18,-29.38,;25.51,-28.61,;24.18,-30.92,)| Show InChI InChI=1S/C144H218N38O43/c1-17-74(10)115(140(221)161-78(14)121(202)168-101(58-84-61-153-89-36-25-24-35-87(84)89)130(211)170-97(54-71(4)5)131(212)179-113(72(6)7)138(219)167-90(37-26-28-50-145)123(204)154-64-108(191)163-95(143(224)225)39-30-52-152-144(149)150)181-132(213)99(55-81-31-20-18-21-32-81)171-128(209)94(46-49-111(195)196)166-127(208)91(38-27-29-51-146)164-119(200)76(12)158-118(199)75(11)160-126(207)93(44-47-106(148)189)162-107(190)63-156-125(206)96(53-70(2)3)169-129(210)98(57-83-40-42-86(188)43-41-83)172-135(216)103(66-183)175-137(218)105(68-185)176-139(220)114(73(8)9)180-134(215)102(60-112(197)198)173-136(217)104(67-184)177-142(223)117(80(16)187)182-133(214)100(56-82-33-22-19-23-34-82)174-141(222)116(79(15)186)178-109(192)65-155-124(205)92(45-48-110(193)194)165-120(201)77(13)159-122(203)88(147)59-85-62-151-69-157-85/h18-25,31-36,40-43,61-62,69-80,88,90-105,113-117,153,183-188H,17,26-30,37-39,44-60,63-68,145-147H2,1-16H3,(H2,148,189)(H,151,157)(H,154,204)(H,155,205)(H,156,206)(H,158,199)(H,159,203)(H,160,207)(H,161,221)(H,162,190)(H,163,191)(H,164,200)(H,165,201)(H,166,208)(H,167,219)(H,168,202)(H,169,210)(H,170,211)(H,171,209)(H,172,216)(H,173,217)(H,174,222)(H,175,218)(H,176,220)(H,177,223)(H,178,192)(H,179,212)(H,180,215)(H,181,213)(H,182,214)(H,193,194)(H,195,196)(H,197,198)(H,224,225)(H4,149,150,152)/t74-,75-,76-,77-,78-,79+,80+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,113-,114-,115-,116-,117-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 5 | n/a | n/a | n/a | n/a |
University of Texas at Dallas
Curated by ChEMBL
| Assay Description
Activation of human GLP1 receptor expressed in HEK293 cells assessed as increase in cAMP accumulation |
J Med Chem 53: 6412-20 (2010)
Article DOI: 10.1021/jm100602m
BindingDB Entry DOI: 10.7270/Q200029G |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50326277
(CHEMBL1240779)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N1)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O |r| Show InChI InChI=1S/C157H235N41O46/c1-16-81(10)126(154(242)184-103-48-54-117(206)165-59-29-26-39-97(134(222)169-72-118(207)175-96(129(161)217)41-31-61-167-157(162)163)183-152(240)124(79(6)7)195-146(234)107(63-78(4)5)186-145(233)111(189-141(103)229)67-90-70-168-95-37-24-23-36-93(90)95)197-147(235)109(64-87-32-19-17-20-33-87)188-142(230)105(51-57-122(213)214)180-137(225)98(38-25-28-58-158)176-131(219)83(12)172-130(218)82(11)174-136(224)101(46-52-115(160)204)179-138(226)99-40-27-30-60-166-116(205)53-47-102(140(228)187-108(66-89-42-44-92(203)45-43-89)144(232)185-106(62-77(2)3)143(231)181-104(139(227)178-99)50-56-121(211)212)182-150(238)113(74-199)192-153(241)125(80(8)9)196-149(237)112(69-123(215)216)190-151(239)114(75-200)193-156(244)128(86(15)202)198-148(236)110(65-88-34-21-18-22-35-88)191-155(243)127(85(14)201)194-119(208)73-170-135(223)100(49-55-120(209)210)177-132(220)84(13)173-133(221)94(159)68-91-71-164-76-171-91/h17-24,32-37,42-45,70-71,76-86,94,96-114,124-128,168,199-203H,16,25-31,38-41,46-69,72-75,158-159H2,1-15H3,(H2,160,204)(H2,161,217)(H,164,171)(H,165,206)(H,166,205)(H,169,222)(H,170,223)(H,172,218)(H,173,221)(H,174,224)(H,175,207)(H,176,219)(H,177,220)(H,178,227)(H,179,226)(H,180,225)(H,181,231)(H,182,238)(H,183,240)(H,184,242)(H,185,232)(H,186,233)(H,187,228)(H,188,230)(H,189,229)(H,190,239)(H,191,243)(H,192,241)(H,193,244)(H,194,208)(H,195,234)(H,196,237)(H,197,235)(H,198,236)(H,209,210)(H,211,212)(H,213,214)(H,215,216)(H4,162,163,167)/t81-,82-,83-,84-,85+,86+,94-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,124-,125-,126-,127-,128-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 2 | n/a | n/a | n/a | n/a |
University of Texas at Dallas
Curated by ChEMBL
| Assay Description
Activation of human GLP1 receptor expressed in HEK293 cells assessed as increase in cAMP accumulation |
J Med Chem 53: 6412-20 (2010)
Article DOI: 10.1021/jm100602m
BindingDB Entry DOI: 10.7270/Q200029G |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50326266
(CHEMBL1240783)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]2CCCCNC(=O)CC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc3cnc[nH]3)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O |r| Show InChI InChI=1S/C154H225N41O48/c1-12-77(6)123(151(241)182-100-45-52-115(205)161-56-24-21-34-93(131(221)166-69-116(206)172-92(126(157)216)37-27-59-164-154(158)159)181-150(240)122(76(4)5)193-144(234)103(60-75(2)3)183-142(232)107(186-138(100)228)64-86-67-165-91-33-20-19-32-89(86)91)194-145(235)105(61-83-28-15-13-16-29-83)184-139(229)102(48-55-120(212)213)179-134(224)94-35-22-25-57-162-113(203)50-43-98(136(226)176-97(42-49-112(156)202)133(223)171-78(7)127(217)169-79(8)128(218)173-94)177-137(227)101(47-54-119(210)211)178-135(225)95-36-23-26-58-163-114(204)51-44-99(140(230)189-110(72-197)149(239)190-109(71-196)147(237)185-104(141(231)175-95)63-85-38-40-88(201)41-39-85)180-143(233)108(66-121(214)215)187-148(238)111(73-198)191-153(243)125(82(11)200)195-146(236)106(62-84-30-17-14-18-31-84)188-152(242)124(81(10)199)192-117(207)70-167-132(222)96(46-53-118(208)209)174-129(219)80(9)170-130(220)90(155)65-87-68-160-74-168-87/h13-20,28-33,38-41,67-68,74-82,90,92-111,122-125,165,196-201H,12,21-27,34-37,42-66,69-73,155H2,1-11H3,(H2,156,202)(H2,157,216)(H,160,168)(H,161,205)(H,162,203)(H,163,204)(H,166,221)(H,167,222)(H,169,217)(H,170,220)(H,171,223)(H,172,206)(H,173,218)(H,174,219)(H,175,231)(H,176,226)(H,177,227)(H,178,225)(H,179,224)(H,180,233)(H,181,240)(H,182,241)(H,183,232)(H,184,229)(H,185,237)(H,186,228)(H,187,238)(H,188,242)(H,189,230)(H,190,239)(H,191,243)(H,192,207)(H,193,234)(H,194,235)(H,195,236)(H,208,209)(H,210,211)(H,212,213)(H,214,215)(H4,158,159,164)/t77-,78-,79-,80-,81+,82+,90-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,122-,123-,124-,125-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a |
University of Texas at Dallas
Curated by ChEMBL
| Assay Description
Activation of human GLP1 receptor expressed in HEK293 cells assessed as increase in cAMP accumulation |
J Med Chem 53: 6412-20 (2010)
Article DOI: 10.1021/jm100602m
BindingDB Entry DOI: 10.7270/Q200029G |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50326276
(CHEMBL1240778)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O |r| Show InChI InChI=1S/C151H223N41O47/c1-12-76(6)121(148(237)178-94-36-23-26-56-159-111(200)49-43-95(129(218)163-67-113(202)170-91(124(155)213)37-27-57-161-151(156)157)179-147(236)120(75(4)5)190-141(230)101(58-74(2)3)180-139(228)105(183-134(94)223)62-85-65-162-90-33-20-19-32-88(85)90)191-142(231)103(59-82-28-15-13-16-29-82)181-137(226)100(47-53-118(209)210)176-133(222)92(34-21-24-54-152)172-126(215)78(8)167-125(214)77(7)169-132(221)98(42-48-110(154)199)171-114(203)68-164-131(220)97(46-52-117(207)208)175-136(225)99-44-50-112(201)160-55-25-22-35-93(135(224)186-108(71-194)146(235)187-107(70-193)144(233)182-102(138(227)177-99)61-84-38-40-87(198)41-39-84)174-140(229)106(64-119(211)212)184-145(234)109(72-195)188-150(239)123(81(11)197)192-143(232)104(60-83-30-17-14-18-31-83)185-149(238)122(80(10)196)189-115(204)69-165-130(219)96(45-51-116(205)206)173-127(216)79(9)168-128(217)89(153)63-86-66-158-73-166-86/h13-20,28-33,38-41,65-66,73-81,89,91-109,120-123,162,193-198H,12,21-27,34-37,42-64,67-72,152-153H2,1-11H3,(H2,154,199)(H2,155,213)(H,158,166)(H,159,200)(H,160,201)(H,163,218)(H,164,220)(H,165,219)(H,167,214)(H,168,217)(H,169,221)(H,170,202)(H,171,203)(H,172,215)(H,173,216)(H,174,229)(H,175,225)(H,176,222)(H,177,227)(H,178,237)(H,179,236)(H,180,228)(H,181,226)(H,182,233)(H,183,223)(H,184,234)(H,185,238)(H,186,224)(H,187,235)(H,188,239)(H,189,204)(H,190,230)(H,191,231)(H,192,232)(H,205,206)(H,207,208)(H,209,210)(H,211,212)(H4,156,157,161)/t76-,77-,78-,79-,80+,81+,89-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,120-,121-,122-,123-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 7 | n/a | n/a | n/a | n/a |
University of Texas at Dallas
Curated by ChEMBL
| Assay Description
Activation of human GLP1 receptor expressed in HEK293 cells assessed as increase in cAMP accumulation |
J Med Chem 53: 6412-20 (2010)
Article DOI: 10.1021/jm100602m
BindingDB Entry DOI: 10.7270/Q200029G |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50326271
(CHEMBL1240776)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O |r| Show InChI InChI=1S/C151H226N40O46/c1-16-77(10)121(148(235)176-98-44-49-111(199)159-54-28-26-37-93(129(216)162-66-112(200)169-92(124(155)211)38-29-55-160-151(156)157)175-146(233)119(75(6)7)188-139(226)101(57-74(4)5)178-138(225)105(181-134(98)221)61-86-64-161-91-35-24-23-34-89(86)91)190-140(227)103(58-83-30-19-17-20-31-83)179-135(222)99(47-52-117(207)208)174-133(220)94(36-25-27-53-152)171-126(213)79(12)166-125(212)78(11)168-132(219)97(43-48-110(154)198)170-113(201)67-163-131(218)96(46-51-116(205)206)173-136(223)100(56-73(2)3)177-137(224)102(60-85-39-41-88(197)42-40-85)180-143(230)107(69-192)184-145(232)109(71-194)185-147(234)120(76(8)9)189-142(229)106(63-118(209)210)182-144(231)108(70-193)186-150(237)123(82(15)196)191-141(228)104(59-84-32-21-18-22-33-84)183-149(236)122(81(14)195)187-114(202)68-164-130(217)95(45-50-115(203)204)172-127(214)80(13)167-128(215)90(153)62-87-65-158-72-165-87/h17-24,30-35,39-42,64-65,72-82,90,92-109,119-123,161,192-197H,16,25-29,36-38,43-63,66-71,152-153H2,1-15H3,(H2,154,198)(H2,155,211)(H,158,165)(H,159,199)(H,162,216)(H,163,218)(H,164,217)(H,166,212)(H,167,215)(H,168,219)(H,169,200)(H,170,201)(H,171,213)(H,172,214)(H,173,223)(H,174,220)(H,175,233)(H,176,235)(H,177,224)(H,178,225)(H,179,222)(H,180,230)(H,181,221)(H,182,231)(H,183,236)(H,184,232)(H,185,234)(H,186,237)(H,187,202)(H,188,226)(H,189,229)(H,190,227)(H,191,228)(H,203,204)(H,205,206)(H,207,208)(H,209,210)(H4,156,157,160)/t77-,78-,79-,80-,81+,82+,90-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,119-,120-,121-,122-,123-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 5.30 | n/a | n/a | n/a | n/a |
University of Texas at Dallas
Curated by ChEMBL
| Assay Description
Activation of human GLP1 receptor expressed in HEK293 cells assessed as increase in cAMP accumulation |
J Med Chem 53: 6412-20 (2010)
Article DOI: 10.1021/jm100602m
BindingDB Entry DOI: 10.7270/Q200029G |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50326272
(CHEMBL1240777)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O |r| Show InChI InChI=1S/C151H223N41O47/c1-12-76(6)121(148(237)179-99-44-50-112(201)159-55-25-22-35-92(129(218)163-67-113(202)170-91(124(155)213)37-27-57-161-151(156)157)178-147(236)120(75(4)5)190-141(230)101(58-74(2)3)180-139(228)105(183-135(99)224)62-85-65-162-90-33-20-19-32-88(85)90)191-142(231)103(59-82-28-15-13-16-29-82)181-136(225)100(47-53-118(209)210)176-133(222)93(34-21-24-54-152)172-126(215)78(8)167-125(214)77(7)169-132(221)97(42-48-110(154)199)171-114(203)68-164-131(220)96(46-52-117(207)208)175-134(223)94-36-23-26-56-160-111(200)49-43-98(137(226)186-108(71-194)146(235)187-107(70-193)144(233)182-102(138(227)174-94)61-84-38-40-87(198)41-39-84)177-140(229)106(64-119(211)212)184-145(234)109(72-195)188-150(239)123(81(11)197)192-143(232)104(60-83-30-17-14-18-31-83)185-149(238)122(80(10)196)189-115(204)69-165-130(219)95(45-51-116(205)206)173-127(216)79(9)168-128(217)89(153)63-86-66-158-73-166-86/h13-20,28-33,38-41,65-66,73-81,89,91-109,120-123,162,193-198H,12,21-27,34-37,42-64,67-72,152-153H2,1-11H3,(H2,154,199)(H2,155,213)(H,158,166)(H,159,201)(H,160,200)(H,163,218)(H,164,220)(H,165,219)(H,167,214)(H,168,217)(H,169,221)(H,170,202)(H,171,203)(H,172,215)(H,173,216)(H,174,227)(H,175,223)(H,176,222)(H,177,229)(H,178,236)(H,179,237)(H,180,228)(H,181,225)(H,182,233)(H,183,224)(H,184,234)(H,185,238)(H,186,226)(H,187,235)(H,188,239)(H,189,204)(H,190,230)(H,191,231)(H,192,232)(H,205,206)(H,207,208)(H,209,210)(H,211,212)(H4,156,157,161)/t76-,77-,78-,79-,80+,81+,89-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,120-,121-,122-,123-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 3.20 | n/a | n/a | n/a | n/a |
University of Texas at Dallas
Curated by ChEMBL
| Assay Description
Activation of human GLP1 receptor expressed in HEK293 cells assessed as increase in cAMP accumulation |
J Med Chem 53: 6412-20 (2010)
Article DOI: 10.1021/jm100602m
BindingDB Entry DOI: 10.7270/Q200029G |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50326275
(CHEMBL1240782)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1)C(=O)N[C@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O |r| Show InChI InChI=1S/C154H228N40O47/c1-16-78(10)123(151(239)178-95-37-26-28-56-161-113(202)50-44-96(131(219)165-68-115(204)171-93(126(157)214)38-29-57-163-154(158)159)179-149(237)121(76(6)7)191-142(230)103(59-75(4)5)181-141(229)107(184-135(95)223)63-87-66-164-92-35-24-23-34-90(87)92)193-143(231)105(60-84-30-19-17-20-31-84)182-138(226)101(48-54-119(210)211)176-136(224)99-45-51-114(203)162-55-27-25-36-94(134(222)175-98(43-49-112(156)201)133(221)170-79(11)127(215)168-80(12)128(216)173-99)174-137(225)100(47-53-118(208)209)177-139(227)102(58-74(2)3)180-140(228)104(62-86-39-41-89(200)42-40-86)183-146(234)109(70-195)187-148(236)111(72-197)188-150(238)122(77(8)9)192-145(233)108(65-120(212)213)185-147(235)110(71-196)189-153(241)125(83(15)199)194-144(232)106(61-85-32-21-18-22-33-85)186-152(240)124(82(14)198)190-116(205)69-166-132(220)97(46-52-117(206)207)172-129(217)81(13)169-130(218)91(155)64-88-67-160-73-167-88/h17-24,30-35,39-42,66-67,73-83,91,93-111,121-125,164,195-200H,16,25-29,36-38,43-65,68-72,155H2,1-15H3,(H2,156,201)(H2,157,214)(H,160,167)(H,161,202)(H,162,203)(H,165,219)(H,166,220)(H,168,215)(H,169,218)(H,170,221)(H,171,204)(H,172,217)(H,173,216)(H,174,225)(H,175,222)(H,176,224)(H,177,227)(H,178,239)(H,179,237)(H,180,228)(H,181,229)(H,182,226)(H,183,234)(H,184,223)(H,185,235)(H,186,240)(H,187,236)(H,188,238)(H,189,241)(H,190,205)(H,191,230)(H,192,233)(H,193,231)(H,194,232)(H,206,207)(H,208,209)(H,210,211)(H,212,213)(H4,158,159,163)/t78-,79-,80-,81-,82+,83+,91-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,121-,122-,123-,124-,125-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 2 | n/a | n/a | n/a | n/a |
University of Texas at Dallas
Curated by ChEMBL
| Assay Description
Activation of human GLP1 receptor expressed in HEK293 cells assessed as increase in cAMP accumulation |
J Med Chem 53: 6412-20 (2010)
Article DOI: 10.1021/jm100602m
BindingDB Entry DOI: 10.7270/Q200029G |
More data for this
Ligand-Target Pair | |
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