Affinity Data by PubMed id=20708929

PubMed code 20708929

Found 13 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
C-C chemokine receptor type 1 (Homo sapiens (Human))	BDBM50325723 ((R)-2-(4-(4-chlorobenzyl)-5-methyl-4H-1,2,4-triazo...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs				Bioorg Med Chem Lett 20: 5477-9 (2010) Article DOI: 10.1016/j.bmcl.2010.07.082 BindingDB Entry DOI: 10.7270/Q2319W3D
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 1 (Homo sapiens (Human))	BDBM50325722 ((R)-2-(4-(4-chlorobenzyl)-4H-1,2,4-triazol-3-yl)-N...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs				Bioorg Med Chem Lett 20: 5477-9 (2010) Article DOI: 10.1016/j.bmcl.2010.07.082 BindingDB Entry DOI: 10.7270/Q2319W3D
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 1 (Homo sapiens (Human))	BDBM50325719 ((R)-2-(1-(4-chlorobenzyl)-1H-tetrazol-5-yl)-N-(4-(...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	6.5	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs				Bioorg Med Chem Lett 20: 5477-9 (2010) Article DOI: 10.1016/j.bmcl.2010.07.082 BindingDB Entry DOI: 10.7270/Q2319W3D
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 1 (Homo sapiens (Human))	BDBM50325718 (2-(1-(4-chlorobenzyl)-1H-imidazol-2-yl)-N-(4-(trif...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs				Bioorg Med Chem Lett 20: 5477-9 (2010) Article DOI: 10.1016/j.bmcl.2010.07.082 BindingDB Entry DOI: 10.7270/Q2319W3D
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 1 (Homo sapiens (Human))	BDBM50325722 ((R)-2-(4-(4-chlorobenzyl)-4H-1,2,4-triazol-3-yl)-N...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Displacement of [125I]-MIP1alpha from human recombinant CCR1 expressed in HEK293 cells after 4 hrs by SPA				Bioorg Med Chem Lett 20: 5477-9 (2010) Article DOI: 10.1016/j.bmcl.2010.07.082 BindingDB Entry DOI: 10.7270/Q2319W3D
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 1 (Homo sapiens (Human))	BDBM50325719 ((R)-2-(1-(4-chlorobenzyl)-1H-tetrazol-5-yl)-N-(4-(...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Displacement of [125I]-MIP1alpha from human recombinant CCR1 expressed in HEK293 cells after 4 hrs by SPA				Bioorg Med Chem Lett 20: 5477-9 (2010) Article DOI: 10.1016/j.bmcl.2010.07.082 BindingDB Entry DOI: 10.7270/Q2319W3D
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 1 (Homo sapiens (Human))	BDBM50293051 ((1S)-N1-(4-chlorobenzyl)-N1-methyl-N2-(4-(trifluor...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs				Bioorg Med Chem Lett 20: 5477-9 (2010) Article DOI: 10.1016/j.bmcl.2010.07.082 BindingDB Entry DOI: 10.7270/Q2319W3D
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 1 (Homo sapiens (Human))	BDBM50325720 ((R)-2-(1-(4-chlorobenzyl)-1H-1,2,4-triazol-5-yl)-N...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs				Bioorg Med Chem Lett 20: 5477-9 (2010) Article DOI: 10.1016/j.bmcl.2010.07.082 BindingDB Entry DOI: 10.7270/Q2319W3D
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 1 (Homo sapiens (Human))	BDBM50325720 ((R)-2-(1-(4-chlorobenzyl)-1H-1,2,4-triazol-5-yl)-N...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Displacement of [125I]-MIP1alpha from human recombinant CCR1 expressed in HEK293 cells after 4 hrs by SPA				Bioorg Med Chem Lett 20: 5477-9 (2010) Article DOI: 10.1016/j.bmcl.2010.07.082 BindingDB Entry DOI: 10.7270/Q2319W3D
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 1 (Homo sapiens (Human))	BDBM50325718 (2-(1-(4-chlorobenzyl)-1H-imidazol-2-yl)-N-(4-(trif...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Displacement of [125I]-MIP1alpha from human recombinant CCR1 expressed in HEK293 cells after 4 hrs by SPA				Bioorg Med Chem Lett 20: 5477-9 (2010) Article DOI: 10.1016/j.bmcl.2010.07.082 BindingDB Entry DOI: 10.7270/Q2319W3D
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 1 (Homo sapiens (Human))	BDBM50325723 ((R)-2-(4-(4-chlorobenzyl)-5-methyl-4H-1,2,4-triazo...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	69	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Displacement of [125I]-MIP1alpha from human recombinant CCR1 expressed in HEK293 cells after 4 hrs by SPA				Bioorg Med Chem Lett 20: 5477-9 (2010) Article DOI: 10.1016/j.bmcl.2010.07.082 BindingDB Entry DOI: 10.7270/Q2319W3D
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 1 (Homo sapiens (Human))	BDBM50293051 ((1S)-N1-(4-chlorobenzyl)-N1-methyl-N2-(4-(trifluor...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Displacement of [125I]-MIP1alpha from human recombinant CCR1 expressed in HEK293 cells after 4 hrs by SPA				Bioorg Med Chem Lett 20: 5477-9 (2010) Article DOI: 10.1016/j.bmcl.2010.07.082 BindingDB Entry DOI: 10.7270/Q2319W3D
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 1 (Homo sapiens (Human))	BDBM50325721 ((R)-2-(1-(4-chlorobenzyl)-3-methyl-1H-1,2,4-triazo...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	810	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Displacement of [125I]-MIP1alpha from human recombinant CCR1 expressed in HEK293 cells after 4 hrs by SPA				Bioorg Med Chem Lett 20: 5477-9 (2010) Article DOI: 10.1016/j.bmcl.2010.07.082 BindingDB Entry DOI: 10.7270/Q2319W3D
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%