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PubMed code 20708930

Compile data set for download or QSAR
Found 36 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50325726
PNG
((R)-N-(2-chlorobenzyl)-1-(3-methoxyphenyl)ethanami...)
Show SMILES COc1cccc(c1)[C@@H](C)NCc1ccccc1Cl |r|
Show InChI InChI=1S/C16H18ClNO/c1-12(13-7-5-8-15(10-13)19-2)18-11-14-6-3-4-9-16(14)17/h3-10,12,18H,11H2,1-2H3/t12-/m1/s1
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n/an/an/an/a 3.70E+3n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calcium


Bioorg Med Chem Lett 20: 5544-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.060
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50325733
PNG
((R)-1-(3-methoxyphenyl)-N-((4'-(trifluoromethyl)bi...)
Show SMILES COc1cccc(c1)[C@@H](C)NCc1cccc(c1)-c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C23H22F3NO/c1-16(19-6-4-8-22(14-19)28-2)27-15-17-5-3-7-20(13-17)18-9-11-21(12-10-18)23(24,25)26/h3-14,16,27H,15H2,1-2H3/t16-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of calcium sensing receptor by FLIPR assay in absence of extracellular calcium


Bioorg Med Chem Lett 20: 5544-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.060
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50325738
PNG
((R)-N-((6-chloro-4'-(trifluoromethyl)biphenyl-3-yl...)
Show SMILES COc1cccc(c1)[C@@H](C)NCc1ccc(Cl)c(c1)-c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C23H21ClF3NO/c1-15(18-4-3-5-20(13-18)29-2)28-14-16-6-11-22(24)21(12-16)17-7-9-19(10-8-17)23(25,26)27/h3-13,15,28H,14H2,1-2H3/t15-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calcium


Bioorg Med Chem Lett 20: 5544-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.060
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50325728
PNG
((R)-N-(4-methoxybenzyl)-1-(3-methoxyphenyl)ethanam...)
Show SMILES COc1ccc(CN[C@H](C)c2cccc(OC)c2)cc1 |r|
Show InChI InChI=1S/C17H21NO2/c1-13(15-5-4-6-17(11-15)20-3)18-12-14-7-9-16(19-2)10-8-14/h4-11,13,18H,12H2,1-3H3/t13-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calcium


Bioorg Med Chem Lett 20: 5544-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.060
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50325732
PNG
((R)-N-((4'-methoxybiphenyl-3-yl)methyl)-1-(3-metho...)
Show SMILES COc1ccc(cc1)-c1cccc(CN[C@H](C)c2cccc(OC)c2)c1 |r|
Show InChI InChI=1S/C23H25NO2/c1-17(20-7-5-9-23(15-20)26-3)24-16-18-6-4-8-21(14-18)19-10-12-22(25-2)13-11-19/h4-15,17,24H,16H2,1-3H3/t17-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calcium


Bioorg Med Chem Lett 20: 5544-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.060
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50325734
PNG
((R)-N-((6-methoxy-4'-(trifluoromethyl)biphenyl-3-y...)
Show SMILES COc1cccc(c1)[C@@H](C)NCc1ccc(OC)c(c1)-c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C24H24F3NO2/c1-16(19-5-4-6-21(14-19)29-2)28-15-17-7-12-23(30-3)22(13-17)18-8-10-20(11-9-18)24(25,26)27/h4-14,16,28H,15H2,1-3H3/t16-/m1/s1
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n/an/an/an/a 23n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calcium


Bioorg Med Chem Lett 20: 5544-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.060
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50325724
PNG
((R)-1-phenyl-N-((6-(trifluoromethoxy)-4'-(trifluor...)
Show SMILES C[C@@H](NCc1ccc(OC(F)(F)F)c(c1)-c1ccc(cc1)C(F)(F)F)c1ccccc1 |r|
Show InChI InChI=1S/C23H19F6NO/c1-15(17-5-3-2-4-6-17)30-14-16-7-12-21(31-23(27,28)29)20(13-16)18-8-10-19(11-9-18)22(24,25)26/h2-13,15,30H,14H2,1H3/t15-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calcium


Bioorg Med Chem Lett 20: 5544-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.060
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50325734
PNG
((R)-N-((6-methoxy-4'-(trifluoromethyl)biphenyl-3-y...)
Show SMILES COc1cccc(c1)[C@@H](C)NCc1ccc(OC)c(c1)-c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C24H24F3NO2/c1-16(19-5-4-6-21(14-19)29-2)28-15-17-7-12-23(30-3)22(13-17)18-8-10-20(11-9-18)24(25,26)27/h4-14,16,28H,15H2,1-3H3/t16-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of calcium sensing receptor by FLIPR assay in absence of extracellular calcium


Bioorg Med Chem Lett 20: 5544-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.060
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50325728
PNG
((R)-N-(4-methoxybenzyl)-1-(3-methoxyphenyl)ethanam...)
Show SMILES COc1ccc(CN[C@H](C)c2cccc(OC)c2)cc1 |r|
Show InChI InChI=1S/C17H21NO2/c1-13(15-5-4-6-17(11-15)20-3)18-12-14-7-9-16(19-2)10-8-14/h4-11,13,18H,12H2,1-3H3/t13-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of calcium sensing receptor by FLIPR assay in absence of extracellular calcium


Bioorg Med Chem Lett 20: 5544-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.060
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50325730
PNG
((R)-1-(3-methoxyphenyl)-N-((2'-methylbiphenyl-3-yl...)
Show SMILES COc1cccc(c1)[C@@H](C)NCc1cccc(c1)-c1ccccc1C |r|
Show InChI InChI=1S/C23H25NO/c1-17-8-4-5-13-23(17)21-11-6-9-19(14-21)16-24-18(2)20-10-7-12-22(15-20)25-3/h4-15,18,24H,16H2,1-3H3/t18-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of calcium sensing receptor by FLIPR assay in absence of extracellular calcium


Bioorg Med Chem Lett 20: 5544-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.060
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50325724
PNG
((R)-1-phenyl-N-((6-(trifluoromethoxy)-4'-(trifluor...)
Show SMILES C[C@@H](NCc1ccc(OC(F)(F)F)c(c1)-c1ccc(cc1)C(F)(F)F)c1ccccc1 |r|
Show InChI InChI=1S/C23H19F6NO/c1-15(17-5-3-2-4-6-17)30-14-16-7-12-21(31-23(27,28)29)20(13-16)18-8-10-19(11-9-18)22(24,25)26/h2-13,15,30H,14H2,1H3/t15-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of calcium sensing receptor by FLIPR assay in absence of extracellular calcium


Bioorg Med Chem Lett 20: 5544-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.060
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50325735
PNG
((R)-N-((6-methoxy-4'-(trifluoromethyl)biphenyl-3-y...)
Show SMILES COc1ccc(CN[C@H](C)c2ccccc2)cc1-c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C23H22F3NO/c1-16(18-6-4-3-5-7-18)27-15-17-8-13-22(28-2)21(14-17)19-9-11-20(12-10-19)23(24,25)26/h3-14,16,27H,15H2,1-2H3/t16-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calcium


Bioorg Med Chem Lett 20: 5544-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.060
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50325731
PNG
((R)-N-((2'-methoxybiphenyl-3-yl)methyl)-1-(3-metho...)
Show SMILES COc1cccc(c1)[C@@H](C)NCc1cccc(c1)-c1ccccc1OC |r|
Show InChI InChI=1S/C23H25NO2/c1-17(19-9-7-11-21(15-19)25-2)24-16-18-8-6-10-20(14-18)22-12-4-5-13-23(22)26-3/h4-15,17,24H,16H2,1-3H3/t17-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of calcium sensing receptor by FLIPR assay in absence of extracellular calcium


Bioorg Med Chem Lett 20: 5544-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.060
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50325732
PNG
((R)-N-((4'-methoxybiphenyl-3-yl)methyl)-1-(3-metho...)
Show SMILES COc1ccc(cc1)-c1cccc(CN[C@H](C)c2cccc(OC)c2)c1 |r|
Show InChI InChI=1S/C23H25NO2/c1-17(20-7-5-9-23(15-20)26-3)24-16-18-6-4-8-21(14-18)19-10-12-22(25-2)13-11-19/h4-15,17,24H,16H2,1-3H3/t17-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of calcium sensing receptor by FLIPR assay in absence of extracellular calcium


Bioorg Med Chem Lett 20: 5544-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.060
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50325738
PNG
((R)-N-((6-chloro-4'-(trifluoromethyl)biphenyl-3-yl...)
Show SMILES COc1cccc(c1)[C@@H](C)NCc1ccc(Cl)c(c1)-c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C23H21ClF3NO/c1-15(18-4-3-5-20(13-18)29-2)28-14-16-6-11-22(24)21(12-16)17-7-9-19(10-8-17)23(25,26)27/h3-13,15,28H,14H2,1-2H3/t15-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of calcium sensing receptor by FLIPR assay in absence of extracellular calcium


Bioorg Med Chem Lett 20: 5544-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.060
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50325733
PNG
((R)-1-(3-methoxyphenyl)-N-((4'-(trifluoromethyl)bi...)
Show SMILES COc1cccc(c1)[C@@H](C)NCc1cccc(c1)-c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C23H22F3NO/c1-16(19-6-4-8-22(14-19)28-2)27-15-17-5-3-7-20(13-17)18-9-11-21(12-10-18)23(24,25)26/h3-14,16,27H,15H2,1-2H3/t16-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calcium


Bioorg Med Chem Lett 20: 5544-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.060
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50325737
PNG
(CHEMBL1224343 | N-((6-methoxy-4'-(trifluoromethyl)...)
Show SMILES COc1ccc(CNC(C)c2cccc(C)c2)cc1-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C24H24F3NO/c1-16-5-4-6-20(13-16)17(2)28-15-18-7-12-23(29-3)22(14-18)19-8-10-21(11-9-19)24(25,26)27/h4-14,17,28H,15H2,1-3H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of calcium sensing receptor by FLIPR assay in absence of extracellular calcium


Bioorg Med Chem Lett 20: 5544-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.060
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50325725
PNG
((R)-N-benzyl-1-(3-methoxyphenyl)ethanamine | CHEMB...)
Show SMILES COc1cccc(c1)[C@@H](C)NCc1ccccc1 |r|
Show InChI InChI=1S/C16H19NO/c1-13(15-9-6-10-16(11-15)18-2)17-12-14-7-4-3-5-8-14/h3-11,13,17H,12H2,1-2H3/t13-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of calcium sensing receptor by FLIPR assay in absence of extracellular calcium


Bioorg Med Chem Lett 20: 5544-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.060
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50325726
PNG
((R)-N-(2-chlorobenzyl)-1-(3-methoxyphenyl)ethanami...)
Show SMILES COc1cccc(c1)[C@@H](C)NCc1ccccc1Cl |r|
Show InChI InChI=1S/C16H18ClNO/c1-12(13-7-5-8-15(10-13)19-2)18-11-14-6-3-4-9-16(14)17/h3-10,12,18H,11H2,1-2H3/t12-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of calcium sensing receptor by FLIPR assay in absence of extracellular calcium


Bioorg Med Chem Lett 20: 5544-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.060
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50325736
PNG
((R)-1-(3-fluorophenyl)-N-((6-methoxy-4'-(trifluoro...)
Show SMILES COc1ccc(CN[C@H](C)c2cccc(F)c2)cc1-c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C23H21F4NO/c1-15(18-4-3-5-20(24)13-18)28-14-16-6-11-22(29-2)21(12-16)17-7-9-19(10-8-17)23(25,26)27/h3-13,15,28H,14H2,1-2H3/t15-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calcium


Bioorg Med Chem Lett 20: 5544-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.060
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50325737
PNG
(CHEMBL1224343 | N-((6-methoxy-4'-(trifluoromethyl)...)
Show SMILES COc1ccc(CNC(C)c2cccc(C)c2)cc1-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C24H24F3NO/c1-16-5-4-6-20(13-16)17(2)28-15-18-7-12-23(29-3)22(14-18)19-8-10-21(11-9-19)24(25,26)27/h4-14,17,28H,15H2,1-3H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calcium


Bioorg Med Chem Lett 20: 5544-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.060
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50325739
PNG
((R)-1-(4-fluorophenyl)-N-((6-methoxy-4'-(trifluoro...)
Show SMILES COc1ccc(CN[C@H](C)c2ccc(F)cc2)cc1-c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C23H21F4NO/c1-15(17-6-10-20(24)11-7-17)28-14-16-3-12-22(29-2)21(13-16)18-4-8-19(9-5-18)23(25,26)27/h3-13,15,28H,14H2,1-2H3/t15-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of calcium sensing receptor by FLIPR assay in absence of extracellular calcium


Bioorg Med Chem Lett 20: 5544-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.060
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50325725
PNG
((R)-N-benzyl-1-(3-methoxyphenyl)ethanamine | CHEMB...)
Show SMILES COc1cccc(c1)[C@@H](C)NCc1ccccc1 |r|
Show InChI InChI=1S/C16H19NO/c1-13(15-9-6-10-16(11-15)18-2)17-12-14-7-4-3-5-8-14/h3-11,13,17H,12H2,1-2H3/t13-/m1/s1
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n/an/an/an/a 1.20E+3n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calcium


Bioorg Med Chem Lett 20: 5544-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.060
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50325729
PNG
((R)-N-((2'-fluorobiphenyl-3-yl)methyl)-1-(3-methox...)
Show SMILES COc1cccc(c1)[C@@H](C)NCc1cccc(c1)-c1ccccc1F |r|
Show InChI InChI=1S/C22H22FNO/c1-16(18-8-6-10-20(14-18)25-2)24-15-17-7-5-9-19(13-17)21-11-3-4-12-22(21)23/h3-14,16,24H,15H2,1-2H3/t16-/m1/s1
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n/an/an/an/a 2.70E+3n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calcium


Bioorg Med Chem Lett 20: 5544-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.060
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50325739
PNG
((R)-1-(4-fluorophenyl)-N-((6-methoxy-4'-(trifluoro...)
Show SMILES COc1ccc(CN[C@H](C)c2ccc(F)cc2)cc1-c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C23H21F4NO/c1-15(17-6-10-20(24)11-7-17)28-14-16-3-12-22(29-2)21(13-16)18-4-8-19(9-5-18)23(25,26)27/h3-13,15,28H,14H2,1-2H3/t15-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calcium


Bioorg Med Chem Lett 20: 5544-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.060
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50325727
PNG
((R)-N-((2'-chlorobiphenyl-3-yl)methyl)-1-(3-methox...)
Show SMILES COc1cccc(c1)[C@@H](C)NCc1cccc(c1)-c1ccccc1Cl |r|
Show InChI InChI=1S/C22H22ClNO/c1-16(18-8-6-10-20(14-18)25-2)24-15-17-7-5-9-19(13-17)21-11-3-4-12-22(21)23/h3-14,16,24H,15H2,1-2H3/t16-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of calcium sensing receptor by FLIPR assay in absence of extracellular calcium


Bioorg Med Chem Lett 20: 5544-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.060
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50325736
PNG
((R)-1-(3-fluorophenyl)-N-((6-methoxy-4'-(trifluoro...)
Show SMILES COc1ccc(CN[C@H](C)c2cccc(F)c2)cc1-c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C23H21F4NO/c1-15(18-4-3-5-20(24)13-18)28-14-16-6-11-22(29-2)21(12-16)17-7-9-19(10-8-17)23(25,26)27/h3-13,15,28H,14H2,1-2H3/t15-/m1/s1
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n/an/an/an/a 1.30E+3n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of calcium sensing receptor by FLIPR assay in absence of extracellular calcium


Bioorg Med Chem Lett 20: 5544-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.060
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50325735
PNG
((R)-N-((6-methoxy-4'-(trifluoromethyl)biphenyl-3-y...)
Show SMILES COc1ccc(CN[C@H](C)c2ccccc2)cc1-c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C23H22F3NO/c1-16(18-6-4-3-5-7-18)27-15-17-8-13-22(28-2)21(14-17)19-9-11-20(12-10-19)23(24,25)26/h3-14,16,27H,15H2,1-2H3/t16-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of calcium sensing receptor by FLIPR assay in absence of extracellular calcium


Bioorg Med Chem Lett 20: 5544-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.060
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50325731
PNG
((R)-N-((2'-methoxybiphenyl-3-yl)methyl)-1-(3-metho...)
Show SMILES COc1cccc(c1)[C@@H](C)NCc1cccc(c1)-c1ccccc1OC |r|
Show InChI InChI=1S/C23H25NO2/c1-17(19-9-7-11-21(15-19)25-2)24-16-18-8-6-10-20(14-18)22-12-4-5-13-23(22)26-3/h4-15,17,24H,16H2,1-3H3/t17-/m1/s1
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n/an/an/an/a 1.40E+3n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calcium


Bioorg Med Chem Lett 20: 5544-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.060
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50325740
PNG
((R)-1-(6-methoxy-4'-(trifluoromethyl)biphenyl-3-yl...)
Show SMILES COc1ccc(cc1-c1ccc(cc1)C(F)(F)F)[C@@H](C)N[C@H](C)c1ccccc1 |r|
Show InChI InChI=1S/C24H24F3NO/c1-16(18-7-5-4-6-8-18)28-17(2)20-11-14-23(29-3)22(15-20)19-9-12-21(13-10-19)24(25,26)27/h4-17,28H,1-3H3/t16-,17-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calcium


Bioorg Med Chem Lett 20: 5544-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.060
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50325729
PNG
((R)-N-((2'-fluorobiphenyl-3-yl)methyl)-1-(3-methox...)
Show SMILES COc1cccc(c1)[C@@H](C)NCc1cccc(c1)-c1ccccc1F |r|
Show InChI InChI=1S/C22H22FNO/c1-16(18-8-6-10-20(14-18)25-2)24-15-17-7-5-9-19(13-17)21-11-3-4-12-22(21)23/h3-14,16,24H,15H2,1-2H3/t16-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of calcium sensing receptor by FLIPR assay in absence of extracellular calcium


Bioorg Med Chem Lett 20: 5544-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.060
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50325741
PNG
((S)-1-(6-methoxy-4'-(trifluoromethyl)biphenyl-3-yl...)
Show SMILES COc1ccc(cc1-c1ccc(cc1)C(F)(F)F)[C@H](C)N[C@H](C)c1ccccc1 |r|
Show InChI InChI=1S/C24H24F3NO/c1-16(18-7-5-4-6-8-18)28-17(2)20-11-14-23(29-3)22(15-20)19-9-12-21(13-10-19)24(25,26)27/h4-17,28H,1-3H3/t16-,17+/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of calcium sensing receptor by FLIPR assay in absence of extracellular calcium


Bioorg Med Chem Lett 20: 5544-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.060
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50325727
PNG
((R)-N-((2'-chlorobiphenyl-3-yl)methyl)-1-(3-methox...)
Show SMILES COc1cccc(c1)[C@@H](C)NCc1cccc(c1)-c1ccccc1Cl |r|
Show InChI InChI=1S/C22H22ClNO/c1-16(18-8-6-10-20(14-18)25-2)24-15-17-7-5-9-19(13-17)21-11-3-4-12-22(21)23/h3-14,16,24H,15H2,1-2H3/t16-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calcium


Bioorg Med Chem Lett 20: 5544-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.060
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50325741
PNG
((S)-1-(6-methoxy-4'-(trifluoromethyl)biphenyl-3-yl...)
Show SMILES COc1ccc(cc1-c1ccc(cc1)C(F)(F)F)[C@H](C)N[C@H](C)c1ccccc1 |r|
Show InChI InChI=1S/C24H24F3NO/c1-16(18-7-5-4-6-8-18)28-17(2)20-11-14-23(29-3)22(15-20)19-9-12-21(13-10-19)24(25,26)27/h4-17,28H,1-3H3/t16-,17+/m1/s1
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n/an/an/an/a 3.00E+3n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calcium


Bioorg Med Chem Lett 20: 5544-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.060
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50325740
PNG
((R)-1-(6-methoxy-4'-(trifluoromethyl)biphenyl-3-yl...)
Show SMILES COc1ccc(cc1-c1ccc(cc1)C(F)(F)F)[C@@H](C)N[C@H](C)c1ccccc1 |r|
Show InChI InChI=1S/C24H24F3NO/c1-16(18-7-5-4-6-8-18)28-17(2)20-11-14-23(29-3)22(15-20)19-9-12-21(13-10-19)24(25,26)27/h4-17,28H,1-3H3/t16-,17-/m1/s1
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n/an/an/an/a 2.10E+3n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of calcium sensing receptor by FLIPR assay in absence of extracellular calcium


Bioorg Med Chem Lett 20: 5544-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.060
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50325730
PNG
((R)-1-(3-methoxyphenyl)-N-((2'-methylbiphenyl-3-yl...)
Show SMILES COc1cccc(c1)[C@@H](C)NCc1cccc(c1)-c1ccccc1C |r|
Show InChI InChI=1S/C23H25NO/c1-17-8-4-5-13-23(17)21-11-6-9-19(14-21)16-24-18(2)20-10-7-12-22(15-20)25-3/h4-15,18,24H,16H2,1-3H3/t18-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calcium


Bioorg Med Chem Lett 20: 5544-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.060
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%