Affinity Data by PubMed id=20727744

PubMed code 20727744

Found 10 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Histamine H3 receptor (Homo sapiens (Human))	BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) Show SMILES Clc1ccc(CCCOCCCN2CCCCC2)cc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	2.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johann Wolfgang Goethe University Curated by ChEMBL					Assay Description Displacement of [125I]Iodoproxyfan from human histamine H3 receptor expressed in HEK293 cells				Bioorg Med Chem Lett 20: 5883-6 (2010) Article DOI: 10.1016/j.bmcl.2010.07.109 BindingDB Entry DOI: 10.7270/Q2BZ6678
Johann Wolfgang Goethe University Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50327227 (4,5-diphenyl-2-(3-(piperidin-1-yl)propylthio)thiaz...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	7.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johann Wolfgang Goethe University Curated by ChEMBL					Assay Description Displacement of [125I]Iodoproxyfan from human histamine H3 receptor expressed in HEK293 cells				Bioorg Med Chem Lett 20: 5883-6 (2010) Article DOI: 10.1016/j.bmcl.2010.07.109 BindingDB Entry DOI: 10.7270/Q2BZ6678
Johann Wolfgang Goethe University Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50327232 (4,5-diphenyl-2-(3-(piperidin-1-yl)propoxy)thiazole...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	11.2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johann Wolfgang Goethe University Curated by ChEMBL					Assay Description Displacement of [125I]Iodoproxyfan from human histamine H3 receptor expressed in HEK293 cells				Bioorg Med Chem Lett 20: 5883-6 (2010) Article DOI: 10.1016/j.bmcl.2010.07.109 BindingDB Entry DOI: 10.7270/Q2BZ6678
Johann Wolfgang Goethe University Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50327233 (2-(3-(piperidin-1-yl)propoxy)-5-(3-(piperidin-1-yl...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johann Wolfgang Goethe University Curated by ChEMBL					Assay Description Displacement of [125I]Iodoproxyfan from human histamine H3 receptor expressed in HEK293 cells				Bioorg Med Chem Lett 20: 5883-6 (2010) Article DOI: 10.1016/j.bmcl.2010.07.109 BindingDB Entry DOI: 10.7270/Q2BZ6678
Johann Wolfgang Goethe University Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50327229 (4,5-diphenyl-2-(3-(piperidin-1-yl)propylthio)oxazo...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	32	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johann Wolfgang Goethe University Curated by ChEMBL					Assay Description Displacement of [125I]Iodoproxyfan from human histamine H3 receptor expressed in HEK293 cells				Bioorg Med Chem Lett 20: 5883-6 (2010) Article DOI: 10.1016/j.bmcl.2010.07.109 BindingDB Entry DOI: 10.7270/Q2BZ6678
Johann Wolfgang Goethe University Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50327225 (5-phenyl-2-(4-(piperidin-1-yl)butyl)oxazole \| CHEM...) Show SMILES C(CCc1ncc(o1)-c1ccccc1)CN1CCCCC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	63	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johann Wolfgang Goethe University Curated by ChEMBL					Assay Description Displacement of [125I]Iodoproxyfan from human histamine H3 receptor expressed in HEK293 cells				Bioorg Med Chem Lett 20: 5883-6 (2010) Article DOI: 10.1016/j.bmcl.2010.07.109 BindingDB Entry DOI: 10.7270/Q2BZ6678
Johann Wolfgang Goethe University Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50327226 (5-(4-(piperidin-1-yl)butyl)-3-(pyridin-3-yl)-1,2,4...) Show SMILES C(CCc1nc(no1)-c1cccnc1)CN1CCCCC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	110	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johann Wolfgang Goethe University Curated by ChEMBL					Assay Description Displacement of [125I]Iodoproxyfan from human histamine H3 receptor expressed in HEK293 cells				Bioorg Med Chem Lett 20: 5883-6 (2010) Article DOI: 10.1016/j.bmcl.2010.07.109 BindingDB Entry DOI: 10.7270/Q2BZ6678
Johann Wolfgang Goethe University Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50327230 (2-(3-(piperidin-1-yl)propylthio)-5-(pyridin-4-yl)-...) Show SMILES C(CSc1nnc(o1)-c1ccncc1)CN1CCCCC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	187	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johann Wolfgang Goethe University Curated by ChEMBL					Assay Description Displacement of [125I]Iodoproxyfan from human histamine H3 receptor expressed in HEK293 cells				Bioorg Med Chem Lett 20: 5883-6 (2010) Article DOI: 10.1016/j.bmcl.2010.07.109 BindingDB Entry DOI: 10.7270/Q2BZ6678
Johann Wolfgang Goethe University Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50327228 (1-(4-methyl-2-(3-(piperidin-1-yl)propylthio)thiazo...) Show SMILES CC(=O)c1sc(SCCCN2CCCCC2)nc1C Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johann Wolfgang Goethe University Curated by ChEMBL					Assay Description Displacement of [125I]Iodoproxyfan from human histamine H3 receptor expressed in HEK293 cells				Bioorg Med Chem Lett 20: 5883-6 (2010) Article DOI: 10.1016/j.bmcl.2010.07.109 BindingDB Entry DOI: 10.7270/Q2BZ6678
Johann Wolfgang Goethe University Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50327231 (4-(1-(3-(piperidin-1-yl)propyl)-3-(3-(piperidin-1-...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a
Johann Wolfgang Goethe University Curated by ChEMBL					Assay Description Displacement of [3H]Methylhistamine from human histamine H3 receptor expressed in HEK293 cells				Bioorg Med Chem Lett 20: 5883-6 (2010) Article DOI: 10.1016/j.bmcl.2010.07.109 BindingDB Entry DOI: 10.7270/Q2BZ6678
Johann Wolfgang Goethe University Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%