Found 15 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Extracellular calcium-sensing receptor
(Homo sapiens (Human)) | BDBM50416876
(CHEMBL1256403)Show InChI InChI=1S/C16H14ClNOS/c1-10-9-11(17)7-8-12(10)16(2,19)15-18-13-5-3-4-6-14(13)20-15/h3-9,19H,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 31.6 | n/a | n/a | n/a | n/a |
ACADIA Pharmaceuticals AB
Curated by ChEMBL
| Assay Description Positive allosteric modulation of calcium sensing receptor by cell based assay |
Bioorg Med Chem Lett 20: 5918-21 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.077 BindingDB Entry DOI: 10.7270/Q22J6D4S |
More data for this Ligand-Target Pair | |
Extracellular calcium-sensing receptor
(Homo sapiens (Human)) | BDBM50416874
(CHEMBL1256368)Show InChI InChI=1S/C17H17NOS/c1-11-8-9-13(12(2)10-11)17(3,19)16-18-14-6-4-5-7-15(14)20-16/h4-10,19H,1-3H3/t17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 25.1 | n/a | n/a | n/a | n/a |
ACADIA Pharmaceuticals AB
Curated by ChEMBL
| Assay Description Positive allosteric modulation of calcium sensing receptor by cell based assay |
Bioorg Med Chem Lett 20: 5918-21 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.077 BindingDB Entry DOI: 10.7270/Q22J6D4S |
More data for this Ligand-Target Pair | |
Extracellular calcium-sensing receptor
(Homo sapiens (Human)) | BDBM50416885
(CHEMBL1258390)Show InChI InChI=1S/C19H15NOS/c1-19(21,18-20-16-8-4-5-9-17(16)22-18)15-11-10-13-6-2-3-7-14(13)12-15/h2-12,21H,1H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 631 | n/a | n/a | n/a | n/a |
ACADIA Pharmaceuticals AB
Curated by ChEMBL
| Assay Description Positive allosteric modulation of calcium sensing receptor by cell based assay |
Bioorg Med Chem Lett 20: 5918-21 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.077 BindingDB Entry DOI: 10.7270/Q22J6D4S |
More data for this Ligand-Target Pair | |
Extracellular calcium-sensing receptor
(Homo sapiens (Human)) | BDBM50416881
(CHEMBL1258389)Show InChI InChI=1S/C19H19NOS/c1-12-7-10-15(13(2)11-12)19(21,14-8-9-14)18-20-16-5-3-4-6-17(16)22-18/h3-7,10-11,14,21H,8-9H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 200 | n/a | n/a | n/a | n/a |
ACADIA Pharmaceuticals AB
Curated by ChEMBL
| Assay Description Positive allosteric modulation of calcium sensing receptor by cell based assay |
Bioorg Med Chem Lett 20: 5918-21 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.077 BindingDB Entry DOI: 10.7270/Q22J6D4S |
More data for this Ligand-Target Pair | |
Extracellular calcium-sensing receptor
(Homo sapiens (Human)) | BDBM50416882
(CHEMBL1256331)Show InChI InChI=1S/C16H15NOS/c1-11-7-3-4-8-12(11)16(2,18)15-17-13-9-5-6-10-14(13)19-15/h3-10,18H,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 251 | n/a | n/a | n/a | n/a |
ACADIA Pharmaceuticals AB
Curated by ChEMBL
| Assay Description Positive allosteric modulation of calcium sensing receptor by cell based assay |
Bioorg Med Chem Lett 20: 5918-21 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.077 BindingDB Entry DOI: 10.7270/Q22J6D4S |
More data for this Ligand-Target Pair | |
Extracellular calcium-sensing receptor
(Homo sapiens (Human)) | BDBM50416874
(CHEMBL1256368)Show InChI InChI=1S/C17H17NOS/c1-11-8-9-13(12(2)10-11)17(3,19)16-18-14-6-4-5-7-15(14)20-16/h4-10,19H,1-3H3/t17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a |
ACADIA Pharmaceuticals AB
Curated by ChEMBL
| Assay Description Positive allosteric modulation of calcium sensing receptor by cell based assay |
Bioorg Med Chem Lett 20: 5918-21 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.077 BindingDB Entry DOI: 10.7270/Q22J6D4S |
More data for this Ligand-Target Pair | |
Extracellular calcium-sensing receptor
(Homo sapiens (Human)) | BDBM50416884
(CHEMBL1256301)Show InChI InChI=1S/C15H12ClNOS/c1-15(18,10-6-8-11(16)9-7-10)14-17-12-4-2-3-5-13(12)19-14/h2-9,18H,1H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 398 | n/a | n/a | n/a | n/a |
ACADIA Pharmaceuticals AB
Curated by ChEMBL
| Assay Description Positive allosteric modulation of calcium sensing receptor by cell based assay |
Bioorg Med Chem Lett 20: 5918-21 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.077 BindingDB Entry DOI: 10.7270/Q22J6D4S |
More data for this Ligand-Target Pair | |
Extracellular calcium-sensing receptor
(Homo sapiens (Human)) | BDBM50416886
(CHEMBL1256486)Show InChI InChI=1S/C17H17NS/c1-11-8-9-14(12(2)10-11)13(3)17-18-15-6-4-5-7-16(15)19-17/h4-10,13H,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 2.51E+3 | n/a | n/a | n/a | n/a |
ACADIA Pharmaceuticals AB
Curated by ChEMBL
| Assay Description Positive allosteric modulation of calcium sensing receptor by cell based assay |
Bioorg Med Chem Lett 20: 5918-21 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.077 BindingDB Entry DOI: 10.7270/Q22J6D4S |
More data for this Ligand-Target Pair | |
Extracellular calcium-sensing receptor
(Homo sapiens (Human)) | BDBM50416887
(CHEMBL1256330)Show InChI InChI=1S/C16H15NO2S/c1-16(18,11-7-3-5-9-13(11)19-2)15-17-12-8-4-6-10-14(12)20-15/h3-10,18H,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 3.98E+3 | n/a | n/a | n/a | n/a |
ACADIA Pharmaceuticals AB
Curated by ChEMBL
| Assay Description Positive allosteric modulation of calcium sensing receptor by cell based assay |
Bioorg Med Chem Lett 20: 5918-21 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.077 BindingDB Entry DOI: 10.7270/Q22J6D4S |
More data for this Ligand-Target Pair | |
Extracellular calcium-sensing receptor
(Homo sapiens (Human)) | BDBM50416875
(AMG-073 | AMG073 HCL | CINACALCET | CINACALCET HYD...)Show SMILES C[C@@H](NCCCc1cccc(c1)C(F)(F)F)c1cccc2ccccc12 |r| Show InChI InChI=1S/C22H22F3N/c1-16(20-13-5-10-18-9-2-3-12-21(18)20)26-14-6-8-17-7-4-11-19(15-17)22(23,24)25/h2-5,7,9-13,15-16,26H,6,8,14H2,1H3/t16-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
DrugBank MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | n/a | n/a | 19.9 | n/a | n/a | n/a | n/a |
ACADIA Pharmaceuticals AB
Curated by ChEMBL
| Assay Description Positive allosteric modulation of calcium sensing receptor by cell based assay |
Bioorg Med Chem Lett 20: 5918-21 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.077 BindingDB Entry DOI: 10.7270/Q22J6D4S |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Extracellular calcium-sensing receptor
(Homo sapiens (Human)) | BDBM50416878
(CHEMBL1256404)Show InChI InChI=1S/C15H11Cl2NOS/c1-15(19,10-7-6-9(16)8-11(10)17)14-18-12-4-2-3-5-13(12)20-14/h2-8,19H,1H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 100 | n/a | n/a | n/a | n/a |
ACADIA Pharmaceuticals AB
Curated by ChEMBL
| Assay Description Positive allosteric modulation of calcium sensing receptor by cell based assay |
Bioorg Med Chem Lett 20: 5918-21 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.077 BindingDB Entry DOI: 10.7270/Q22J6D4S |
More data for this Ligand-Target Pair | |
Extracellular calcium-sensing receptor
(Homo sapiens (Human)) | BDBM50416883
(CHEMBL1255602)Show InChI InChI=1S/C19H19NOS/c1-12-10-13(2)14-6-5-9-19(21,15(14)11-12)18-20-16-7-3-4-8-17(16)22-18/h3-4,7-8,10-11,21H,5-6,9H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 316 | n/a | n/a | n/a | n/a |
ACADIA Pharmaceuticals AB
Curated by ChEMBL
| Assay Description Positive allosteric modulation of calcium sensing receptor by cell based assay |
Bioorg Med Chem Lett 20: 5918-21 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.077 BindingDB Entry DOI: 10.7270/Q22J6D4S |
More data for this Ligand-Target Pair | |
Extracellular calcium-sensing receptor
(Homo sapiens (Human)) | BDBM50416879
(CHEMBL1256303)Show InChI InChI=1S/C15H11Cl2NOS/c1-15(19,9-6-7-10(16)11(17)8-9)14-18-12-4-2-3-5-13(12)20-14/h2-8,19H,1H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 100 | n/a | n/a | n/a | n/a |
ACADIA Pharmaceuticals AB
Curated by ChEMBL
| Assay Description Positive allosteric modulation of calcium sensing receptor by cell based assay |
Bioorg Med Chem Lett 20: 5918-21 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.077 BindingDB Entry DOI: 10.7270/Q22J6D4S |
More data for this Ligand-Target Pair | |
Extracellular calcium-sensing receptor
(Homo sapiens (Human)) | BDBM50416880
(CHEMBL1256366)Show InChI InChI=1S/C16H14FNOS/c1-10-9-11(7-8-12(10)17)16(2,19)15-18-13-5-3-4-6-14(13)20-15/h3-9,19H,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 158 | n/a | n/a | n/a | n/a |
ACADIA Pharmaceuticals AB
Curated by ChEMBL
| Assay Description Positive allosteric modulation of calcium sensing receptor by cell based assay |
Bioorg Med Chem Lett 20: 5918-21 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.077 BindingDB Entry DOI: 10.7270/Q22J6D4S |
More data for this Ligand-Target Pair | |
Extracellular calcium-sensing receptor
(Homo sapiens (Human)) | BDBM50416877
(CHEMBL1256402)Show InChI InChI=1S/C17H17NOS/c1-11-8-9-13(12(2)10-11)17(3,19)16-18-14-6-4-5-7-15(14)20-16/h4-10,19H,1-3H3/t17-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 79.4 | n/a | n/a | n/a | n/a |
ACADIA Pharmaceuticals AB
Curated by ChEMBL
| Assay Description Positive allosteric modulation of calcium sensing receptor by cell based assay |
Bioorg Med Chem Lett 20: 5918-21 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.077 BindingDB Entry DOI: 10.7270/Q22J6D4S |
More data for this Ligand-Target Pair | |