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PubMed code 20801651

Compile data set for download or QSAR
Found 25 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Muscarinic acetylcholine receptor M5


(Homo sapiens (Human))		BDBM50327644
PNG
(1-((6-phenylpyridin-3-yl)methyl)-5-(trifluorometho...)
Show SMILES FC(F)(F)Oc1ccc2N(Cc3ccc(nc3)-c3ccccc3)C(=O)C(=O)c2c1
Show InChI InChI=1S/C21H13F3N2O3/c22-21(23,24)29-15-7-9-18-16(10-15)19(27)20(28)26(18)12-13-6-8-17(25-11-13)14-4-2-1-3-5-14/h1-11H,12H2
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n/an/an/an/a 3.80E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mob...

Bioorg Med Chem Lett 20: 5617-22 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.042
BindingDB Entry DOI: 10.7270/Q2CR5TK2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))		BDBM50258439
PNG
(1-(4-bromobenzyl)indoline-2,3-dione | CHEMBL523685...)
Show SMILES Brc1ccc(CN2C(=O)C(=O)c3ccccc23)cc1
Show InChI InChI=1S/C15H10BrNO2/c16-11-7-5-10(6-8-11)9-17-13-4-2-1-3-12(13)14(18)15(17)19/h1-8H,9H2
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as effect on acetylcholine-induced intrac...

Bioorg Med Chem Lett 20: 5617-22 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.042
BindingDB Entry DOI: 10.7270/Q2CR5TK2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50258439
PNG
(1-(4-bromobenzyl)indoline-2,3-dione | CHEMBL523685...)
Show SMILES Brc1ccc(CN2C(=O)C(=O)c3ccccc23)cc1
Show InChI InChI=1S/C15H10BrNO2/c16-11-7-5-10(6-8-11)9-17-13-4-2-1-3-12(13)14(18)15(17)19/h1-8H,9H2
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as effect on acetylcholine-induced intrac...

Bioorg Med Chem Lett 20: 5617-22 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.042
BindingDB Entry DOI: 10.7270/Q2CR5TK2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M5


(Homo sapiens (Human))		BDBM50258439
PNG
(1-(4-bromobenzyl)indoline-2,3-dione | CHEMBL523685...)
Show SMILES Brc1ccc(CN2C(=O)C(=O)c3ccccc23)cc1
Show InChI InChI=1S/C15H10BrNO2/c16-11-7-5-10(6-8-11)9-17-13-4-2-1-3-12(13)14(18)15(17)19/h1-8H,9H2
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n/an/an/an/a 4.60E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mob...

Bioorg Med Chem Lett 20: 5617-22 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.042
BindingDB Entry DOI: 10.7270/Q2CR5TK2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M5


(Homo sapiens (Human))		BDBM50327634
PNG
(1-((3,5-difluorobiphenyl-4-yl)methyl)-5-(trifluoro...)
Show SMILES Fc1cc(cc(F)c1CN1C(=O)C(=O)c2cc(OC(F)(F)F)ccc12)-c1ccccc1
Show InChI InChI=1S/C22H12F5NO3/c23-17-8-13(12-4-2-1-3-5-12)9-18(24)16(17)11-28-19-7-6-14(31-22(25,26)27)10-15(19)20(29)21(28)30/h1-10H,11H2
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mob...

Bioorg Med Chem Lett 20: 5617-22 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.042
BindingDB Entry DOI: 10.7270/Q2CR5TK2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M5


(Homo sapiens (Human))		BDBM50327635
PNG
(1-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(trifluoromet...)
Show SMILES FC(F)(F)Oc1ccc2N(Cc3ccc4OCOc4c3)C(=O)C(=O)c2c1
Show InChI InChI=1S/C17H10F3NO5/c18-17(19,20)26-10-2-3-12-11(6-10)15(22)16(23)21(12)7-9-1-4-13-14(5-9)25-8-24-13/h1-6H,7-8H2
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n/an/an/an/a 3.20E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mob...

Bioorg Med Chem Lett 20: 5617-22 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.042
BindingDB Entry DOI: 10.7270/Q2CR5TK2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M5


(Homo sapiens (Human))		BDBM50327637
PNG
(1-(4-(pyridin-3-yl)benzyl)-5-(trifluoromethoxy)ind...)
Show SMILES FC(F)(F)Oc1ccc2N(Cc3ccc(cc3)-c3cccnc3)C(=O)C(=O)c2c1
Show InChI InChI=1S/C21H13F3N2O3/c22-21(23,24)29-16-7-8-18-17(10-16)19(27)20(28)26(18)12-13-3-5-14(6-4-13)15-2-1-9-25-11-15/h1-11H,12H2
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n/an/an/an/a 1.60E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mob...

Bioorg Med Chem Lett 20: 5617-22 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.042
BindingDB Entry DOI: 10.7270/Q2CR5TK2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M5


(Homo sapiens (Human))		BDBM50327643
PNG
(1-(3,4'-bipyridin-6-ylmethyl)-5-(trifluoromethoxy)...)
Show SMILES FC(F)(F)Oc1ccc2N(Cc3ccc(cn3)-c3ccncc3)C(=O)C(=O)c2c1
Show InChI InChI=1S/C20H12F3N3O3/c21-20(22,23)29-15-3-4-17-16(9-15)18(27)19(28)26(17)11-14-2-1-13(10-25-14)12-5-7-24-8-6-12/h1-10H,11H2
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mob...

Bioorg Med Chem Lett 20: 5617-22 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.042
BindingDB Entry DOI: 10.7270/Q2CR5TK2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M5


(Homo sapiens (Human))		BDBM50327636
PNG
(1-(3-phenoxybenzyl)-5-(trifluoromethoxy)indoline-2...)
Show SMILES FC(F)(F)Oc1ccc2N(Cc3cccc(Oc4ccccc4)c3)C(=O)C(=O)c2c1
Show InChI InChI=1S/C22H14F3NO4/c23-22(24,25)30-17-9-10-19-18(12-17)20(27)21(28)26(19)13-14-5-4-8-16(11-14)29-15-6-2-1-3-7-15/h1-12H,13H2
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mob...

Bioorg Med Chem Lett 20: 5617-22 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.042
BindingDB Entry DOI: 10.7270/Q2CR5TK2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M5


(Homo sapiens (Human))		BDBM50327640
PNG
(1-((6-chloropyridin-3-yl)methyl)-5-(trifluorometho...)
Show SMILES FC(F)(F)Oc1ccc2N(Cc3ccc(Cl)nc3)C(=O)C(=O)c2c1
Show InChI InChI=1S/C15H8ClF3N2O3/c16-12-4-1-8(6-20-12)7-21-11-3-2-9(24-15(17,18)19)5-10(11)13(22)14(21)23/h1-6H,7H2
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n/an/an/an/a 2.40E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mob...

Bioorg Med Chem Lett 20: 5617-22 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.042
BindingDB Entry DOI: 10.7270/Q2CR5TK2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M5


(Homo sapiens (Human))		BDBM50327645
PNG
(1-(2,3'-bipyridin-5-ylmethyl)-5-(trifluoromethoxy)...)
Show SMILES FC(F)(F)Oc1ccc2N(Cc3ccc(nc3)-c3cccnc3)C(=O)C(=O)c2c1
Show InChI InChI=1S/C20H12F3N3O3/c21-20(22,23)29-14-4-6-17-15(8-14)18(27)19(28)26(17)11-12-3-5-16(25-9-12)13-2-1-7-24-10-13/h1-10H,11H2
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n/an/an/an/a 4.00E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mob...

Bioorg Med Chem Lett 20: 5617-22 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.042
BindingDB Entry DOI: 10.7270/Q2CR5TK2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M5


(Homo sapiens (Human))		BDBM50327632
PNG
(1-(biphenyl-3-ylmethyl)-5-(trifluoromethoxy)indoli...)
Show SMILES FC(F)(F)Oc1ccc2N(Cc3cccc(c3)-c3ccccc3)C(=O)C(=O)c2c1
Show InChI InChI=1S/C22H14F3NO3/c23-22(24,25)29-17-9-10-19-18(12-17)20(27)21(28)26(19)13-14-5-4-8-16(11-14)15-6-2-1-3-7-15/h1-12H,13H2
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mob...

Bioorg Med Chem Lett 20: 5617-22 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.042
BindingDB Entry DOI: 10.7270/Q2CR5TK2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M5


(Homo sapiens (Human))		BDBM50305818
PNG
(1-(biphenyl-4-ylmethyl)-5-(trifluoromethoxy)indoli...)
Show SMILES FC(F)(F)Oc1ccc2N(Cc3ccc(cc3)-c3ccccc3)C(=O)C(=O)c2c1
Show InChI InChI=1S/C22H14F3NO3/c23-22(24,25)29-17-10-11-19-18(12-17)20(27)21(28)26(19)13-14-6-8-16(9-7-14)15-4-2-1-3-5-15/h1-12H,13H2
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n/an/an/an/a 1.60E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mob...

Bioorg Med Chem Lett 20: 5617-22 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.042
BindingDB Entry DOI: 10.7270/Q2CR5TK2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M5


(Homo sapiens (Human))		BDBM50327647
PNG
(1-(4-(pyridin-2-yloxy)benzyl)-5-(trifluoromethoxy)...)
Show SMILES FC(F)(F)Oc1ccc2N(Cc3ccc(Oc4ccccn4)cc3)C(=O)C(=O)c2c1
Show InChI InChI=1S/C21H13F3N2O4/c22-21(23,24)30-15-8-9-17-16(11-15)19(27)20(28)26(17)12-13-4-6-14(7-5-13)29-18-3-1-2-10-25-18/h1-11H,12H2
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n/an/an/an/a 3.20E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mob...

Bioorg Med Chem Lett 20: 5617-22 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.042
BindingDB Entry DOI: 10.7270/Q2CR5TK2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M5


(Homo sapiens (Human))		BDBM50327649
PNG
(1-(4-(6-methoxypyridin-2-yloxy)benzyl)-5-(trifluor...)
Show SMILES COc1cccc(Oc2ccc(CN3C(=O)C(=O)c4cc(OC(F)(F)F)ccc34)cc2)n1
Show InChI InChI=1S/C22H15F3N2O5/c1-30-18-3-2-4-19(26-18)31-14-7-5-13(6-8-14)12-27-17-10-9-15(32-22(23,24)25)11-16(17)20(28)21(27)29/h2-11H,12H2,1H3
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n/an/an/an/a 2.20E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mob...

Bioorg Med Chem Lett 20: 5617-22 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.042
BindingDB Entry DOI: 10.7270/Q2CR5TK2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M5


(Homo sapiens (Human))		BDBM50327638
PNG
(1-(4-(pyridin-4-yl)benzyl)-5-(trifluoromethoxy)ind...)
Show SMILES FC(F)(F)Oc1ccc2N(Cc3ccc(cc3)-c3ccncc3)C(=O)C(=O)c2c1
Show InChI InChI=1S/C21H13F3N2O3/c22-21(23,24)29-16-5-6-18-17(11-16)19(27)20(28)26(18)12-13-1-3-14(4-2-13)15-7-9-25-10-8-15/h1-11H,12H2
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n/an/an/an/a 2.80E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mob...

Bioorg Med Chem Lett 20: 5617-22 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.042
BindingDB Entry DOI: 10.7270/Q2CR5TK2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M5


(Homo sapiens (Human))		BDBM50327641
PNG
(1-((5-phenylpyridin-2-yl)methyl)-5-(trifluorometho...)
Show SMILES FC(F)(F)Oc1ccc2N(Cc3ccc(cn3)-c3ccccc3)C(=O)C(=O)c2c1
Show InChI InChI=1S/C21H13F3N2O3/c22-21(23,24)29-16-8-9-18-17(10-16)19(27)20(28)26(18)12-15-7-6-14(11-25-15)13-4-2-1-3-5-13/h1-11H,12H2
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n/an/an/an/a 3.10E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mob...

Bioorg Med Chem Lett 20: 5617-22 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.042
BindingDB Entry DOI: 10.7270/Q2CR5TK2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50258439
PNG
(1-(4-bromobenzyl)indoline-2,3-dione | CHEMBL523685...)
Show SMILES Brc1ccc(CN2C(=O)C(=O)c3ccccc23)cc1
Show InChI InChI=1S/C15H10BrNO2/c16-11-7-5-10(6-8-11)9-17-13-4-2-1-3-12(13)14(18)15(17)19/h1-8H,9H2
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n/an/an/an/a 6.40E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of muscarinic M3 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mob...

Bioorg Med Chem Lett 20: 5617-22 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.042
BindingDB Entry DOI: 10.7270/Q2CR5TK2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M5


(Homo sapiens (Human))		BDBM50327633
PNG
(1-((3-fluorobiphenyl-4-yl)methyl)-5-(trifluorometh...)
Show SMILES Fc1cc(ccc1CN1C(=O)C(=O)c2cc(OC(F)(F)F)ccc12)-c1ccccc1
Show InChI InChI=1S/C22H13F4NO3/c23-18-10-14(13-4-2-1-3-5-13)6-7-15(18)12-27-19-9-8-16(30-22(24,25)26)11-17(19)20(28)21(27)29/h1-11H,12H2
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n/an/an/an/a 5.90E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mob...

Bioorg Med Chem Lett 20: 5617-22 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.042
BindingDB Entry DOI: 10.7270/Q2CR5TK2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M5


(Homo sapiens (Human))		BDBM50327642
PNG
(1-(3,3'-bipyridin-6-ylmethyl)-5-(trifluoromethoxy)...)
Show SMILES FC(F)(F)Oc1ccc2N(Cc3ccc(cn3)-c3cccnc3)C(=O)C(=O)c2c1
Show InChI InChI=1S/C20H12F3N3O3/c21-20(22,23)29-15-5-6-17-16(8-15)18(27)19(28)26(17)11-14-4-3-13(10-25-14)12-2-1-7-24-9-12/h1-10H,11H2
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mob...

Bioorg Med Chem Lett 20: 5617-22 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.042
BindingDB Entry DOI: 10.7270/Q2CR5TK2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M5


(Homo sapiens (Human))		BDBM50327650
PNG
(1-(4-(thiazol-2-yloxy)benzyl)-5-(trifluoromethoxy)...)
Show SMILES FC(F)(F)Oc1ccc2N(Cc3ccc(Oc4nccs4)cc3)C(=O)C(=O)c2c1
Show InChI InChI=1S/C19H11F3N2O4S/c20-19(21,22)28-13-5-6-15-14(9-13)16(25)17(26)24(15)10-11-1-3-12(4-2-11)27-18-23-7-8-29-18/h1-9H,10H2
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n/an/an/an/a 2.80E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mob...

Bioorg Med Chem Lett 20: 5617-22 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.042
BindingDB Entry DOI: 10.7270/Q2CR5TK2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M5


(Homo sapiens (Human))		BDBM50327639
PNG
(1-(4-(pyrimidin-5-yl)benzyl)-5-(trifluoromethoxy)i...)
Show SMILES FC(F)(F)Oc1ccc2N(Cc3ccc(cc3)-c3cncnc3)C(=O)C(=O)c2c1
Show InChI InChI=1S/C20H12F3N3O3/c21-20(22,23)29-15-5-6-17-16(7-15)18(27)19(28)26(17)10-12-1-3-13(4-2-12)14-8-24-11-25-9-14/h1-9,11H,10H2
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n/an/an/an/a 2.10E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mob...

Bioorg Med Chem Lett 20: 5617-22 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.042
BindingDB Entry DOI: 10.7270/Q2CR5TK2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M5


(Homo sapiens (Human))		BDBM50327648
PNG
(1-(4-(6-fluoropyridin-2-yloxy)benzyl)-5-(trifluoro...)
Show SMILES Fc1cccc(Oc2ccc(CN3C(=O)C(=O)c4cc(OC(F)(F)F)ccc34)cc2)n1
Show InChI InChI=1S/C21H12F4N2O4/c22-17-2-1-3-18(26-17)30-13-6-4-12(5-7-13)11-27-16-9-8-14(31-21(23,24)25)10-15(16)19(28)20(27)29/h1-10H,11H2
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n/an/an/an/a 1.50E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mob...

Bioorg Med Chem Lett 20: 5617-22 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.042
BindingDB Entry DOI: 10.7270/Q2CR5TK2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50258439
PNG
(1-(4-bromobenzyl)indoline-2,3-dione | CHEMBL523685...)
Show SMILES Brc1ccc(CN2C(=O)C(=O)c3ccccc23)cc1
Show InChI InChI=1S/C15H10BrNO2/c16-11-7-5-10(6-8-11)9-17-13-4-2-1-3-12(13)14(18)15(17)19/h1-8H,9H2
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n/an/an/an/a 6.10E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mob...

Bioorg Med Chem Lett 20: 5617-22 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.042
BindingDB Entry DOI: 10.7270/Q2CR5TK2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M5


(Homo sapiens (Human))		BDBM50327646
PNG
(1-(2,4'-bipyridin-5-ylmethyl)-5-(trifluoromethoxy)...)
Show SMILES FC(F)(F)Oc1ccc2N(Cc3ccc(nc3)-c3ccncc3)C(=O)C(=O)c2c1
Show InChI InChI=1S/C20H12F3N3O3/c21-20(22,23)29-14-2-4-17-15(9-14)18(27)19(28)26(17)11-12-1-3-16(25-10-12)13-5-7-24-8-6-13/h1-10H,11H2
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n/an/an/an/a 4.40E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mob...

Bioorg Med Chem Lett 20: 5617-22 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.042
BindingDB Entry DOI: 10.7270/Q2CR5TK2
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%