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PubMed code 20822901

Compile data set for download or QSAR
Found 8 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM26106
PNG
(CHEMBL90852 | N-oxalyl glycine, 1a | NOG | Oxalylg...)
Show SMILES OC(=O)CNC(=O)C(O)=O
Show InChI InChI=1S/C4H5NO5/c6-2(7)1-5-3(8)4(9)10/h1H2,(H,5,8)(H,6,7)(H,9,10)
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PubMed
n/an/a 842n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of PHD1 by HTRF assay


Bioorg Med Chem Lett 20: 6125-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.032
BindingDB Entry DOI: 10.7270/Q22B8Z7F
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM26110
PNG
(N,3-dihydroxybenzamide | aromatic hydroxamic acid,...)
Show SMILES ONC(=O)c1cccc(O)c1
Show InChI InChI=1S/C7H7NO3/c9-6-3-1-2-5(4-6)7(10)8-11/h1-4,9,11H,(H,8,10)
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Article
PubMed
n/an/a 1.84E+4n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of PHD1 by HTRF assay


Bioorg Med Chem Lett 20: 6125-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.032
BindingDB Entry DOI: 10.7270/Q22B8Z7F
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM50328019
PNG
(2-(3-hydroxypicolinamido)acetic acid | CHEMBL12565...)
Show SMILES OC(=O)CNC(=O)c1ncccc1O
Show InChI InChI=1S/C8H8N2O4/c11-5-2-1-3-9-7(5)8(14)10-4-6(12)13/h1-3,11H,4H2,(H,10,14)(H,12,13)
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PubMed
n/an/a 9.11E+4n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of PHD1 by HTRF assay


Bioorg Med Chem Lett 20: 6125-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.032
BindingDB Entry DOI: 10.7270/Q22B8Z7F
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM50328018
PNG
(2-(3-hydroxyphenyl)-2-mercaptoacetic acid | CHEMBL...)
Show SMILES OC(=O)C(S)c1cccc(O)c1
Show InChI InChI=1S/C8H8O3S/c9-6-3-1-2-5(4-6)7(12)8(10)11/h1-4,7,9,12H,(H,10,11)
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KEGG
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5.00E+5n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of PHD1 by HTRF assay


Bioorg Med Chem Lett 20: 6125-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.032
BindingDB Entry DOI: 10.7270/Q22B8Z7F
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM26113
PNG
(2,4 PDCA | cid_10365 | pyridine carboxylate, 6a | ...)
Show SMILES OC(=O)c1ccnc(c1)C(O)=O
Show InChI InChI=1S/C7H5NO4/c9-6(10)4-1-2-8-5(3-4)7(11)12/h1-3H,(H,9,10)(H,11,12)
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PubMed
n/an/a 6.25E+5n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of PHD1 by HTRF assay


Bioorg Med Chem Lett 20: 6125-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.032
BindingDB Entry DOI: 10.7270/Q22B8Z7F
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM50328017
PNG
(2-(3-HYDROXYPHENYL)-2-OXO-ETHANOIC ACID | 2-(3-hyd...)
Show SMILES OC(=O)C(=O)c1cccc(O)c1
Show InChI InChI=1S/C8H6O4/c9-6-3-1-2-5(4-6)7(10)8(11)12/h1-4,9H,(H,11,12)
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Article
PubMed
n/an/a>1.00E+6n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of PHD1 by HTRF assay


Bioorg Med Chem Lett 20: 6125-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.032
BindingDB Entry DOI: 10.7270/Q22B8Z7F
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM50328020
PNG
(2-(picolinamido)acetic acid | CHEMBL221255)
Show SMILES OC(=O)CNC(=O)c1ccccn1
Show InChI InChI=1S/C8H8N2O3/c11-7(12)5-10-8(13)6-3-1-2-4-9-6/h1-4H,5H2,(H,10,13)(H,11,12)
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PC cid
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Article
PubMed
n/an/a>1.00E+6n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of PHD1 by HTRF assay


Bioorg Med Chem Lett 20: 6125-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.032
BindingDB Entry DOI: 10.7270/Q22B8Z7F
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM50328021
PNG
((2-Hydroxy-benzoylamino)-acetic acid | 2-(2-hydrox...)
Show SMILES OC(=O)CNC(=O)c1ccccc1O
Show InChI InChI=1S/C9H9NO4/c11-7-4-2-1-3-6(7)9(14)10-5-8(12)13/h1-4,11H,5H2,(H,10,14)(H,12,13)
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CHEMBL
KEGG
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Article
PubMed
n/an/a>1.00E+6n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of PHD1 by HTRF assay


Bioorg Med Chem Lett 20: 6125-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.032
BindingDB Entry DOI: 10.7270/Q22B8Z7F
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%