Affinity Data by PubMed id=20889347

PubMed code 20889347

Found 14 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50329778 ((-)-(R,R)-5-Fluoro-3-(4-phenyl-piperidin-1-yl)-1,2...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.57	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Displacement of (-)-[3H]pentazocine from sigma 1 receptor in rat cortical membranes after 120 mins				Bioorg Med Chem 18: 7659-67 (2010) Article DOI: 10.1016/j.bmc.2010.08.028 BindingDB Entry DOI: 10.7270/Q2PK0GCD
INSERM Curated by ChEMBL					More data for this Ligand-Target Pair
Vesicular acetylcholine transporter (Rattus norvegicus)	BDBM50329778 ((-)-(R,R)-5-Fluoro-3-(4-phenyl-piperidin-1-yl)-1,2...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.68	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Displacement of (-)-[3H]vesamicol from rat VAChT expressed in rat PC12 cells after 60 mins				Bioorg Med Chem 18: 7659-67 (2010) Article DOI: 10.1016/j.bmc.2010.08.028 BindingDB Entry DOI: 10.7270/Q2PK0GCD
INSERM Curated by ChEMBL					More data for this Ligand-Target Pair
Vesicular acetylcholine transporter (Rattus norvegicus)	BDBM50329777 ((+)-(S,S)-5-Fluoro-3-(4-phenyl-piperidin-1-yl)-1,2...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6.95	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Displacement of (-)-[3H]vesamicol from rat VAChT expressed in rat PC12 cells after 60 mins				Bioorg Med Chem 18: 7659-67 (2010) Article DOI: 10.1016/j.bmc.2010.08.028 BindingDB Entry DOI: 10.7270/Q2PK0GCD
INSERM Curated by ChEMBL					More data for this Ligand-Target Pair
Vesicular acetylcholine transporter (Rattus norvegicus)	BDBM50329776 ((rac)-5-Fluoro-3-(4-phenyl-piperidin-1-yl)-1,2,3,4...) Show SMILES OC1Cc2cccc(F)c2CC1N1CCC(CC1)c1ccccc1 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	10.9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Displacement of (-)-[3H]vesamicol from rat VAChT expressed in rat PC12 cells after 60 mins				Bioorg Med Chem 18: 7659-67 (2010) Article DOI: 10.1016/j.bmc.2010.08.028 BindingDB Entry DOI: 10.7270/Q2PK0GCD
INSERM Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50329776 ((rac)-5-Fluoro-3-(4-phenyl-piperidin-1-yl)-1,2,3,4...) Show SMILES OC1Cc2cccc(F)c2CC1N1CCC(CC1)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	13.2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Displacement of (-)-[3H]pentazocine from sigma 1 receptor in rat cortical membranes after 120 mins				Bioorg Med Chem 18: 7659-67 (2010) Article DOI: 10.1016/j.bmc.2010.08.028 BindingDB Entry DOI: 10.7270/Q2PK0GCD
INSERM Curated by ChEMBL					More data for this Ligand-Target Pair
Vesicular acetylcholine transporter (Rattus norvegicus)	BDBM50329775 ((2R,3R)-5-Iodo-3-(4-phenyl-piperidin-1-yl)-1,2,3,4...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	15.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Displacement of (-)-[3H]vesamicol from rat VAChT expressed in rat PC12 cells after 60 mins				Bioorg Med Chem 18: 7659-67 (2010) Article DOI: 10.1016/j.bmc.2010.08.028 BindingDB Entry DOI: 10.7270/Q2PK0GCD
INSERM Curated by ChEMBL					More data for this Ligand-Target Pair
Vesicular acetylcholine transporter (Rattus norvegicus)	BDBM50329773 ((-)-(2R,3R)-5-(2-fluoroethoxy)-3-(4-phenylpiperidi...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	19.6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Displacement of (-)-[3H]vesamicol from rat VAChT expressed in rat PC12 cells after 60 mins				Bioorg Med Chem 18: 7659-67 (2010) Article DOI: 10.1016/j.bmc.2010.08.028 BindingDB Entry DOI: 10.7270/Q2PK0GCD
INSERM Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50329777 ((+)-(S,S)-5-Fluoro-3-(4-phenyl-piperidin-1-yl)-1,2...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	38.1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Displacement of (-)-[3H]pentazocine from sigma 1 receptor in rat cortical membranes after 120 mins				Bioorg Med Chem 18: 7659-67 (2010) Article DOI: 10.1016/j.bmc.2010.08.028 BindingDB Entry DOI: 10.7270/Q2PK0GCD
INSERM Curated by ChEMBL					More data for this Ligand-Target Pair
Vesicular acetylcholine transporter (Rattus norvegicus)	BDBM50018079 (5-Amino-3-(4-phenyl-piperidin-1-yl)-1,2,3,4-tetrah...) Show SMILES Nc1cccc2CC(O)C(Cc12)N1CCC(CC1)c1ccccc1 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	40.6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Displacement of (-)-[3H]vesamicol from rat VAChT expressed in rat PC12 cells after 60 mins				Bioorg Med Chem 18: 7659-67 (2010) Article DOI: 10.1016/j.bmc.2010.08.028 BindingDB Entry DOI: 10.7270/Q2PK0GCD
INSERM Curated by ChEMBL					More data for this Ligand-Target Pair
Vesicular acetylcholine transporter (Rattus norvegicus)	BDBM50329774 ((+)-(2S,3S)-5-(2-fluoroethoxy)-3-(4-phenylpiperidi...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	56.9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Displacement of (-)-[3H]vesamicol from rat VAChT expressed in rat PC12 cells after 60 mins				Bioorg Med Chem 18: 7659-67 (2010) Article DOI: 10.1016/j.bmc.2010.08.028 BindingDB Entry DOI: 10.7270/Q2PK0GCD
INSERM Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50329773 ((-)-(2R,3R)-5-(2-fluoroethoxy)-3-(4-phenylpiperidi...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	209	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Displacement of (-)-[3H]pentazocine from sigma 1 receptor in rat cortical membranes after 120 mins				Bioorg Med Chem 18: 7659-67 (2010) Article DOI: 10.1016/j.bmc.2010.08.028 BindingDB Entry DOI: 10.7270/Q2PK0GCD
INSERM Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50329775 ((2R,3R)-5-Iodo-3-(4-phenyl-piperidin-1-yl)-1,2,3,4...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	266	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Displacement of (-)-[3H]pentazocine from sigma 1 receptor in rat cortical membranes after 120 mins				Bioorg Med Chem 18: 7659-67 (2010) Article DOI: 10.1016/j.bmc.2010.08.028 BindingDB Entry DOI: 10.7270/Q2PK0GCD
INSERM Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50329774 ((+)-(2S,3S)-5-(2-fluoroethoxy)-3-(4-phenylpiperidi...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	269	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Displacement of (-)-[3H]pentazocine from sigma 1 receptor in rat cortical membranes after 120 mins				Bioorg Med Chem 18: 7659-67 (2010) Article DOI: 10.1016/j.bmc.2010.08.028 BindingDB Entry DOI: 10.7270/Q2PK0GCD
INSERM Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50018079 (5-Amino-3-(4-phenyl-piperidin-1-yl)-1,2,3,4-tetrah...) Show SMILES Nc1cccc2CC(O)C(Cc12)N1CCC(CC1)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	652	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Displacement of (-)-[3H]pentazocine from sigma 1 receptor in rat cortical membranes after 120 mins				Bioorg Med Chem 18: 7659-67 (2010) Article DOI: 10.1016/j.bmc.2010.08.028 BindingDB Entry DOI: 10.7270/Q2PK0GCD
INSERM Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%