Found 61 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50329885
(4-(6-(4-(2-morpholinoethoxy)phenyl)pyrazolo[1,5-a]...)Show SMILES Oc1ccc(cc1O)-c1cnn2cc(cnc12)-c1ccc(OCCN2CCOCC2)cc1 Show InChI InChI=1S/C24H24N4O4/c29-22-6-3-18(13-23(22)30)21-15-26-28-16-19(14-25-24(21)28)17-1-4-20(5-2-17)32-12-9-27-7-10-31-11-8-27/h1-6,13-16,29-30H,7-12H2 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM5416
(4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-...)Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1 Show InChI InChI=1S/C23H23N5O2/c1-3-21(30-14-11-27-9-12-29-13-10-27)4-2-18(1)20-15-25-23-22(16-26-28(23)17-20)19-5-7-24-8-6-19/h1-8,15-17H,9-14H2 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50329882
(4-(6-(4-(2-morpholinoethoxy)phenyl)pyrazolo[1,5-a]...)Show SMILES Nc1cc(ccn1)-c1cnn2cc(cnc12)-c1ccc(OCCN2CCOCC2)cc1 Show InChI InChI=1S/C23H24N6O2/c24-22-13-18(5-6-25-22)21-15-27-29-16-19(14-26-23(21)29)17-1-3-20(4-2-17)31-12-9-28-7-10-30-11-8-28/h1-6,13-16H,7-12H2,(H2,24,25) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50329885
(4-(6-(4-(2-morpholinoethoxy)phenyl)pyrazolo[1,5-a]...)Show SMILES Oc1ccc(cc1O)-c1cnn2cc(cnc12)-c1ccc(OCCN2CCOCC2)cc1 Show InChI InChI=1S/C24H24N4O4/c29-22-6-3-18(13-23(22)30)21-15-26-28-16-19(14-25-24(21)28)17-1-4-20(5-2-17)32-12-9-27-7-10-31-11-8-27/h1-6,13-16,29-30H,7-12H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of KDR by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50329885
(4-(6-(4-(2-morpholinoethoxy)phenyl)pyrazolo[1,5-a]...)Show SMILES Oc1ccc(cc1O)-c1cnn2cc(cnc12)-c1ccc(OCCN2CCOCC2)cc1 Show InChI InChI=1S/C24H24N4O4/c29-22-6-3-18(13-23(22)30)21-15-26-28-16-19(14-25-24(21)28)17-1-4-20(5-2-17)32-12-9-27-7-10-31-11-8-27/h1-6,13-16,29-30H,7-12H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of FLT1 by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50262685
(6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-...)Show SMILES C(CN1CCCCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1 Show InChI InChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of c-SRC by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262685
(6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-...)Show SMILES C(CN1CCCCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1 Show InChI InChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of KDR by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50329881
(4-(2-(4-(3-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimid...)Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1cn[nH]c1 Show InChI InChI=1S/C21H22N6O2/c1-3-19(29-10-7-26-5-8-28-9-6-26)4-2-16(1)18-11-22-21-20(14-25-27(21)15-18)17-12-23-24-13-17/h1-4,11-15H,5-10H2,(H,23,24) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of FLT1 by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50329881
(4-(2-(4-(3-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimid...)Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1cn[nH]c1 Show InChI InChI=1S/C21H22N6O2/c1-3-19(29-10-7-26-5-8-28-9-6-26)4-2-16(1)18-11-22-21-20(14-25-27(21)15-18)17-12-23-24-13-17/h1-4,11-15H,5-10H2,(H,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of KDR by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM50262685
(6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-...)Show SMILES C(CN1CCCCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1 Show InChI InChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of MNK1 by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Ephrin type-A receptor 2
(Homo sapiens (Human)) | BDBM50262685
(6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-...)Show SMILES C(CN1CCCCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1 Show InChI InChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of EphA2 by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50262685
(6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-...)Show SMILES C(CN1CCCCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1 Show InChI InChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of FLT1 by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50262685
(6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-...)Show SMILES C(CN1CCCCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1 Show InChI InChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of LCK by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50329885
(4-(6-(4-(2-morpholinoethoxy)phenyl)pyrazolo[1,5-a]...)Show SMILES Oc1ccc(cc1O)-c1cnn2cc(cnc12)-c1ccc(OCCN2CCOCC2)cc1 Show InChI InChI=1S/C24H24N4O4/c29-22-6-3-18(13-23(22)30)21-15-26-28-16-19(14-25-24(21)28)17-1-4-20(5-2-17)32-12-9-27-7-10-31-11-8-27/h1-6,13-16,29-30H,7-12H2 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of LCK by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50329882
(4-(6-(4-(2-morpholinoethoxy)phenyl)pyrazolo[1,5-a]...)Show SMILES Nc1cc(ccn1)-c1cnn2cc(cnc12)-c1ccc(OCCN2CCOCC2)cc1 Show InChI InChI=1S/C23H24N6O2/c24-22-13-18(5-6-25-22)21-15-27-29-16-19(14-26-23(21)29)17-1-3-20(4-2-17)31-12-9-28-7-10-30-11-8-28/h1-6,13-16H,7-12H2,(H2,24,25) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of c-SRC by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM50329881
(4-(2-(4-(3-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimid...)Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1cn[nH]c1 Show InChI InChI=1S/C21H22N6O2/c1-3-19(29-10-7-26-5-8-28-9-6-26)4-2-16(1)18-11-22-21-20(14-25-27(21)15-18)17-12-23-24-13-17/h1-4,11-15H,5-10H2,(H,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of MNK1 by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50329882
(4-(6-(4-(2-morpholinoethoxy)phenyl)pyrazolo[1,5-a]...)Show SMILES Nc1cc(ccn1)-c1cnn2cc(cnc12)-c1ccc(OCCN2CCOCC2)cc1 Show InChI InChI=1S/C23H24N6O2/c24-22-13-18(5-6-25-22)21-15-27-29-16-19(14-26-23(21)29)17-1-3-20(4-2-17)31-12-9-28-7-10-30-11-8-28/h1-6,13-16H,7-12H2,(H2,24,25) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of FLT1 by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM50329879
(5-(6-(4-(2-morpholinoethoxy)phenyl)pyrazolo[1,5-a]...)Show SMILES O=c1ccc(c[nH]1)-c1cnn2cc(cnc12)-c1ccc(OCCN2CCOCC2)cc1 Show InChI InChI=1S/C23H23N5O3/c29-22-6-3-18(13-24-22)21-15-26-28-16-19(14-25-23(21)28)17-1-4-20(5-2-17)31-12-9-27-7-10-30-11-8-27/h1-6,13-16H,7-12H2,(H,24,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of MNK1 by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM5416
(4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-...)Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1 Show InChI InChI=1S/C23H23N5O2/c1-3-21(30-14-11-27-9-12-29-13-10-27)4-2-18(1)20-15-25-23-22(16-26-28(23)17-20)19-5-7-24-8-6-19/h1-8,15-17H,9-14H2 | PDB
MMDB
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| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of c-SRC by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM5416
(4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-...)Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1 Show InChI InChI=1S/C23H23N5O2/c1-3-21(30-14-11-27-9-12-29-13-10-27)4-2-18(1)20-15-25-23-22(16-26-28(23)17-20)19-5-7-24-8-6-19/h1-8,15-17H,9-14H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
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CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of KDR by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50329882
(4-(6-(4-(2-morpholinoethoxy)phenyl)pyrazolo[1,5-a]...)Show SMILES Nc1cc(ccn1)-c1cnn2cc(cnc12)-c1ccc(OCCN2CCOCC2)cc1 Show InChI InChI=1S/C23H24N6O2/c24-22-13-18(5-6-25-22)21-15-27-29-16-19(14-26-23(21)29)17-1-3-20(4-2-17)31-12-9-28-7-10-30-11-8-28/h1-6,13-16H,7-12H2,(H2,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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B.MOAD
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of KDR by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50329879
(5-(6-(4-(2-morpholinoethoxy)phenyl)pyrazolo[1,5-a]...)Show SMILES O=c1ccc(c[nH]1)-c1cnn2cc(cnc12)-c1ccc(OCCN2CCOCC2)cc1 Show InChI InChI=1S/C23H23N5O3/c29-22-6-3-18(13-24-22)21-15-26-28-16-19(14-25-23(21)28)17-1-4-20(5-2-17)31-12-9-27-7-10-30-11-8-27/h1-6,13-16H,7-12H2,(H,24,29) | PDB
MMDB
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PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 61 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of c-SRC by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50329886
(4-(5-(3,4-dihydroxyphenyl)oxazol-2-ylamino)benzene...)Show SMILES NS(=O)(=O)c1ccc(Nc2ncc(o2)-c2ccc(O)c(O)c2)cc1 Show InChI InChI=1S/C15H13N3O5S/c16-24(21,22)11-4-2-10(3-5-11)18-15-17-8-14(23-15)9-1-6-12(19)13(20)7-9/h1-8,19-20H,(H,17,18)(H2,16,21,22) | PDB
MMDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 74 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of FLT1 by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50329881
(4-(2-(4-(3-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimid...)Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1cn[nH]c1 Show InChI InChI=1S/C21H22N6O2/c1-3-19(29-10-7-26-5-8-28-9-6-26)4-2-16(1)18-11-22-21-20(14-25-27(21)15-18)17-12-23-24-13-17/h1-4,11-15H,5-10H2,(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 94 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of LCK by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50329885
(4-(6-(4-(2-morpholinoethoxy)phenyl)pyrazolo[1,5-a]...)Show SMILES Oc1ccc(cc1O)-c1cnn2cc(cnc12)-c1ccc(OCCN2CCOCC2)cc1 Show InChI InChI=1S/C24H24N4O4/c29-22-6-3-18(13-23(22)30)21-15-26-28-16-19(14-25-24(21)28)17-1-4-20(5-2-17)32-12-9-27-7-10-31-11-8-27/h1-6,13-16,29-30H,7-12H2 | PDB
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| CHEMBL
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PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 96 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of c-SRC by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50329886
(4-(5-(3,4-dihydroxyphenyl)oxazol-2-ylamino)benzene...)Show SMILES NS(=O)(=O)c1ccc(Nc2ncc(o2)-c2ccc(O)c(O)c2)cc1 Show InChI InChI=1S/C15H13N3O5S/c16-24(21,22)11-4-2-10(3-5-11)18-15-17-8-14(23-15)9-1-6-12(19)13(20)7-9/h1-8,19-20H,(H,17,18)(H2,16,21,22) | PDB
MMDB
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Reactome pathway
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of KDR by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50329879
(5-(6-(4-(2-morpholinoethoxy)phenyl)pyrazolo[1,5-a]...)Show SMILES O=c1ccc(c[nH]1)-c1cnn2cc(cnc12)-c1ccc(OCCN2CCOCC2)cc1 Show InChI InChI=1S/C23H23N5O3/c29-22-6-3-18(13-24-22)21-15-26-28-16-19(14-25-23(21)28)17-1-4-20(5-2-17)31-12-9-27-7-10-30-11-8-27/h1-6,13-16H,7-12H2,(H,24,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
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GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of KDR by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50329876
(4-(5-(6-oxo-1,6-dihydropyridin-3-yl)oxazol-2-ylami...)Show SMILES NS(=O)(=O)c1ccc(Nc2ncc(o2)-c2ccc(=O)[nH]c2)cc1 Show InChI InChI=1S/C14H12N4O4S/c15-23(20,21)11-4-2-10(3-5-11)18-14-17-8-12(22-14)9-1-6-13(19)16-7-9/h1-8H,(H,16,19)(H,17,18)(H2,15,20,21) | PDB
NCI pathway
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KEGG
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| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM5416
(4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-...)Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1 Show InChI InChI=1S/C23H23N5O2/c1-3-21(30-14-11-27-9-12-29-13-10-27)4-2-18(1)20-15-25-23-22(16-26-28(23)17-20)19-5-7-24-8-6-19/h1-8,15-17H,9-14H2 | PDB
MMDB
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PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of MNK1 by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50329886
(4-(5-(3,4-dihydroxyphenyl)oxazol-2-ylamino)benzene...)Show SMILES NS(=O)(=O)c1ccc(Nc2ncc(o2)-c2ccc(O)c(O)c2)cc1 Show InChI InChI=1S/C15H13N3O5S/c16-24(21,22)11-4-2-10(3-5-11)18-15-17-8-14(23-15)9-1-6-12(19)13(20)7-9/h1-8,19-20H,(H,17,18)(H2,16,21,22) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM50329882
(4-(6-(4-(2-morpholinoethoxy)phenyl)pyrazolo[1,5-a]...)Show SMILES Nc1cc(ccn1)-c1cnn2cc(cnc12)-c1ccc(OCCN2CCOCC2)cc1 Show InChI InChI=1S/C23H24N6O2/c24-22-13-18(5-6-25-22)21-15-27-29-16-19(14-26-23(21)29)17-1-3-20(4-2-17)31-12-9-28-7-10-30-11-8-28/h1-6,13-16H,7-12H2,(H2,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 164 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of MNK1 by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM5416
(4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-...)Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1 Show InChI InChI=1S/C23H23N5O2/c1-3-21(30-14-11-27-9-12-29-13-10-27)4-2-18(1)20-15-25-23-22(16-26-28(23)17-20)19-5-7-24-8-6-19/h1-8,15-17H,9-14H2 | PDB
MMDB
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PC sid
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PubMed
| n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of FLT1 by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-1
(Homo sapiens (Human)) | BDBM50262685
(6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-...)Show SMILES C(CN1CCCCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1 Show InChI InChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2 | PDB
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PC cid
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PDB
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| Article
PubMed
| n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of RSK1 by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-1
(Homo sapiens (Human)) | BDBM50329881
(4-(2-(4-(3-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimid...)Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1cn[nH]c1 Show InChI InChI=1S/C21H22N6O2/c1-3-19(29-10-7-26-5-8-28-9-6-26)4-2-16(1)18-11-22-21-20(14-25-27(21)15-18)17-12-23-24-13-17/h1-4,11-15H,5-10H2,(H,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of RSK1 by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Ephrin type-A receptor 2
(Homo sapiens (Human)) | BDBM5416
(4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-...)Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1 Show InChI InChI=1S/C23H23N5O2/c1-3-21(30-14-11-27-9-12-29-13-10-27)4-2-18(1)20-15-25-23-22(16-26-28(23)17-20)19-5-7-24-8-6-19/h1-8,15-17H,9-14H2 | PDB
MMDB
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CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of EphA2 by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Ephrin type-A receptor 2
(Homo sapiens (Human)) | BDBM50329879
(5-(6-(4-(2-morpholinoethoxy)phenyl)pyrazolo[1,5-a]...)Show SMILES O=c1ccc(c[nH]1)-c1cnn2cc(cnc12)-c1ccc(OCCN2CCOCC2)cc1 Show InChI InChI=1S/C23H23N5O3/c29-22-6-3-18(13-24-22)21-15-26-28-16-19(14-25-23(21)28)17-1-4-20(5-2-17)31-12-9-27-7-10-30-11-8-27/h1-6,13-16H,7-12H2,(H,24,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of EphA2 by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Ephrin type-A receptor 2
(Homo sapiens (Human)) | BDBM50329881
(4-(2-(4-(3-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimid...)Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1cn[nH]c1 Show InChI InChI=1S/C21H22N6O2/c1-3-19(29-10-7-26-5-8-28-9-6-26)4-2-16(1)18-11-22-21-20(14-25-27(21)15-18)17-12-23-24-13-17/h1-4,11-15H,5-10H2,(H,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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B.MOAD
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| CHEMBL
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PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of EphA2 by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM5416
(4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-...)Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1 Show InChI InChI=1S/C23H23N5O2/c1-3-21(30-14-11-27-9-12-29-13-10-27)4-2-18(1)20-15-25-23-22(16-26-28(23)17-20)19-5-7-24-8-6-19/h1-8,15-17H,9-14H2 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of LCK by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50329879
(5-(6-(4-(2-morpholinoethoxy)phenyl)pyrazolo[1,5-a]...)Show SMILES O=c1ccc(c[nH]1)-c1cnn2cc(cnc12)-c1ccc(OCCN2CCOCC2)cc1 Show InChI InChI=1S/C23H23N5O3/c29-22-6-3-18(13-24-22)21-15-26-28-16-19(14-25-23(21)28)17-1-4-20(5-2-17)31-12-9-27-7-10-30-11-8-27/h1-6,13-16H,7-12H2,(H,24,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 430 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of LCK by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50329882
(4-(6-(4-(2-morpholinoethoxy)phenyl)pyrazolo[1,5-a]...)Show SMILES Nc1cc(ccn1)-c1cnn2cc(cnc12)-c1ccc(OCCN2CCOCC2)cc1 Show InChI InChI=1S/C23H24N6O2/c24-22-13-18(5-6-25-22)21-15-27-29-16-19(14-26-23(21)29)17-1-3-20(4-2-17)31-12-9-28-7-10-30-11-8-28/h1-6,13-16H,7-12H2,(H2,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of LCK by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50329879
(5-(6-(4-(2-morpholinoethoxy)phenyl)pyrazolo[1,5-a]...)Show SMILES O=c1ccc(c[nH]1)-c1cnn2cc(cnc12)-c1ccc(OCCN2CCOCC2)cc1 Show InChI InChI=1S/C23H23N5O3/c29-22-6-3-18(13-24-22)21-15-26-28-16-19(14-25-23(21)28)17-1-4-20(5-2-17)31-12-9-27-7-10-30-11-8-27/h1-6,13-16H,7-12H2,(H,24,29) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 470 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of FLT1 by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-1
(Homo sapiens (Human)) | BDBM50329885
(4-(6-(4-(2-morpholinoethoxy)phenyl)pyrazolo[1,5-a]...)Show SMILES Oc1ccc(cc1O)-c1cnn2cc(cnc12)-c1ccc(OCCN2CCOCC2)cc1 Show InChI InChI=1S/C24H24N4O4/c29-22-6-3-18(13-23(22)30)21-15-26-28-16-19(14-25-24(21)28)17-1-4-20(5-2-17)32-12-9-27-7-10-31-11-8-27/h1-6,13-16,29-30H,7-12H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 560 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of RSK1 by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Ephrin type-A receptor 2
(Homo sapiens (Human)) | BDBM50329885
(4-(6-(4-(2-morpholinoethoxy)phenyl)pyrazolo[1,5-a]...)Show SMILES Oc1ccc(cc1O)-c1cnn2cc(cnc12)-c1ccc(OCCN2CCOCC2)cc1 Show InChI InChI=1S/C24H24N4O4/c29-22-6-3-18(13-23(22)30)21-15-26-28-16-19(14-25-24(21)28)17-1-4-20(5-2-17)32-12-9-27-7-10-31-11-8-27/h1-6,13-16,29-30H,7-12H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 740 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of EphA2 by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Ephrin type-A receptor 2
(Homo sapiens (Human)) | BDBM50329882
(4-(6-(4-(2-morpholinoethoxy)phenyl)pyrazolo[1,5-a]...)Show SMILES Nc1cc(ccn1)-c1cnn2cc(cnc12)-c1ccc(OCCN2CCOCC2)cc1 Show InChI InChI=1S/C23H24N6O2/c24-22-13-18(5-6-25-22)21-15-27-29-16-19(14-26-23(21)29)17-1-3-20(4-2-17)31-12-9-28-7-10-30-11-8-28/h1-6,13-16H,7-12H2,(H2,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 840 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of EphA2 by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM50329885
(4-(6-(4-(2-morpholinoethoxy)phenyl)pyrazolo[1,5-a]...)Show SMILES Oc1ccc(cc1O)-c1cnn2cc(cnc12)-c1ccc(OCCN2CCOCC2)cc1 Show InChI InChI=1S/C24H24N4O4/c29-22-6-3-18(13-23(22)30)21-15-26-28-16-19(14-25-24(21)28)17-1-4-20(5-2-17)32-12-9-27-7-10-31-11-8-27/h1-6,13-16,29-30H,7-12H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 950 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of MNK1 by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50329886
(4-(5-(3,4-dihydroxyphenyl)oxazol-2-ylamino)benzene...)Show SMILES NS(=O)(=O)c1ccc(Nc2ncc(o2)-c2ccc(O)c(O)c2)cc1 Show InChI InChI=1S/C15H13N3O5S/c16-24(21,22)11-4-2-10(3-5-11)18-15-17-8-14(23-15)9-1-6-12(19)13(20)7-9/h1-8,19-20H,(H,17,18)(H2,16,21,22) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 970 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of LCK by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-1
(Homo sapiens (Human)) | BDBM50329882
(4-(6-(4-(2-morpholinoethoxy)phenyl)pyrazolo[1,5-a]...)Show SMILES Nc1cc(ccn1)-c1cnn2cc(cnc12)-c1ccc(OCCN2CCOCC2)cc1 Show InChI InChI=1S/C23H24N6O2/c24-22-13-18(5-6-25-22)21-15-27-29-16-19(14-26-23(21)29)17-1-3-20(4-2-17)31-12-9-28-7-10-30-11-8-28/h1-6,13-16H,7-12H2,(H2,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of RSK1 by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM50329876
(4-(5-(6-oxo-1,6-dihydropyridin-3-yl)oxazol-2-ylami...)Show SMILES NS(=O)(=O)c1ccc(Nc2ncc(o2)-c2ccc(=O)[nH]c2)cc1 Show InChI InChI=1S/C14H12N4O4S/c15-23(20,21)11-4-2-10(3-5-11)18-14-17-8-12(22-14)9-1-6-13(19)16-7-9/h1-8H,(H,16,19)(H,17,18)(H2,15,20,21) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of MNK1 by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-1
(Homo sapiens (Human)) | BDBM5416
(4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-...)Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1 Show InChI InChI=1S/C23H23N5O2/c1-3-21(30-14-11-27-9-12-29-13-10-27)4-2-18(1)20-15-25-23-22(16-26-28(23)17-20)19-5-7-24-8-6-19/h1-8,15-17H,9-14H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of RSK1 by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-1
(Homo sapiens (Human)) | BDBM50329879
(5-(6-(4-(2-morpholinoethoxy)phenyl)pyrazolo[1,5-a]...)Show SMILES O=c1ccc(c[nH]1)-c1cnn2cc(cnc12)-c1ccc(OCCN2CCOCC2)cc1 Show InChI InChI=1S/C23H23N5O3/c29-22-6-3-18(13-24-22)21-15-26-28-16-19(14-25-23(21)28)17-1-4-20(5-2-17)31-12-9-27-7-10-30-11-8-27/h1-6,13-16H,7-12H2,(H,24,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of RSK1 by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM50329886
(4-(5-(3,4-dihydroxyphenyl)oxazol-2-ylamino)benzene...)Show SMILES NS(=O)(=O)c1ccc(Nc2ncc(o2)-c2ccc(O)c(O)c2)cc1 Show InChI InChI=1S/C15H13N3O5S/c16-24(21,22)11-4-2-10(3-5-11)18-15-17-8-14(23-15)9-1-6-12(19)13(20)7-9/h1-8,19-20H,(H,17,18)(H2,16,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of MNK1 by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50329886
(4-(5-(3,4-dihydroxyphenyl)oxazol-2-ylamino)benzene...)Show SMILES NS(=O)(=O)c1ccc(Nc2ncc(o2)-c2ccc(O)c(O)c2)cc1 Show InChI InChI=1S/C15H13N3O5S/c16-24(21,22)11-4-2-10(3-5-11)18-15-17-8-14(23-15)9-1-6-12(19)13(20)7-9/h1-8,19-20H,(H,17,18)(H2,16,21,22) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of c-SRC by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50329881
(4-(2-(4-(3-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimid...)Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1cn[nH]c1 Show InChI InChI=1S/C21H22N6O2/c1-3-19(29-10-7-26-5-8-28-9-6-26)4-2-16(1)18-11-22-21-20(14-25-27(21)15-18)17-12-23-24-13-17/h1-4,11-15H,5-10H2,(H,23,24) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of c-SRC by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-1
(Homo sapiens (Human)) | BDBM50329886
(4-(5-(3,4-dihydroxyphenyl)oxazol-2-ylamino)benzene...)Show SMILES NS(=O)(=O)c1ccc(Nc2ncc(o2)-c2ccc(O)c(O)c2)cc1 Show InChI InChI=1S/C15H13N3O5S/c16-24(21,22)11-4-2-10(3-5-11)18-15-17-8-14(23-15)9-1-6-12(19)13(20)7-9/h1-8,19-20H,(H,17,18)(H2,16,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of RSK1 by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Ephrin type-A receptor 2
(Homo sapiens (Human)) | BDBM50329876
(4-(5-(6-oxo-1,6-dihydropyridin-3-yl)oxazol-2-ylami...)Show SMILES NS(=O)(=O)c1ccc(Nc2ncc(o2)-c2ccc(=O)[nH]c2)cc1 Show InChI InChI=1S/C14H12N4O4S/c15-23(20,21)11-4-2-10(3-5-11)18-14-17-8-12(22-14)9-1-6-13(19)16-7-9/h1-8H,(H,16,19)(H,17,18)(H2,15,20,21) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of EphA2 by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50329876
(4-(5-(6-oxo-1,6-dihydropyridin-3-yl)oxazol-2-ylami...)Show SMILES NS(=O)(=O)c1ccc(Nc2ncc(o2)-c2ccc(=O)[nH]c2)cc1 Show InChI InChI=1S/C14H12N4O4S/c15-23(20,21)11-4-2-10(3-5-11)18-14-17-8-12(22-14)9-1-6-13(19)16-7-9/h1-8H,(H,16,19)(H,17,18)(H2,15,20,21) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of c-SRC by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Ephrin type-A receptor 2
(Homo sapiens (Human)) | BDBM50329886
(4-(5-(3,4-dihydroxyphenyl)oxazol-2-ylamino)benzene...)Show SMILES NS(=O)(=O)c1ccc(Nc2ncc(o2)-c2ccc(O)c(O)c2)cc1 Show InChI InChI=1S/C15H13N3O5S/c16-24(21,22)11-4-2-10(3-5-11)18-15-17-8-14(23-15)9-1-6-12(19)13(20)7-9/h1-8,19-20H,(H,17,18)(H2,16,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of EphA2 by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50329876
(4-(5-(6-oxo-1,6-dihydropyridin-3-yl)oxazol-2-ylami...)Show SMILES NS(=O)(=O)c1ccc(Nc2ncc(o2)-c2ccc(=O)[nH]c2)cc1 Show InChI InChI=1S/C14H12N4O4S/c15-23(20,21)11-4-2-10(3-5-11)18-14-17-8-12(22-14)9-1-6-13(19)16-7-9/h1-8H,(H,16,19)(H,17,18)(H2,15,20,21) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of FLT1 by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50329876
(4-(5-(6-oxo-1,6-dihydropyridin-3-yl)oxazol-2-ylami...)Show SMILES NS(=O)(=O)c1ccc(Nc2ncc(o2)-c2ccc(=O)[nH]c2)cc1 Show InChI InChI=1S/C14H12N4O4S/c15-23(20,21)11-4-2-10(3-5-11)18-14-17-8-12(22-14)9-1-6-13(19)16-7-9/h1-8H,(H,16,19)(H,17,18)(H2,15,20,21) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of LCK by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-1
(Homo sapiens (Human)) | BDBM50329876
(4-(5-(6-oxo-1,6-dihydropyridin-3-yl)oxazol-2-ylami...)Show SMILES NS(=O)(=O)c1ccc(Nc2ncc(o2)-c2ccc(=O)[nH]c2)cc1 Show InChI InChI=1S/C14H12N4O4S/c15-23(20,21)11-4-2-10(3-5-11)18-14-17-8-12(22-14)9-1-6-13(19)16-7-9/h1-8H,(H,16,19)(H,17,18)(H2,15,20,21) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of RSK1 by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50329876
(4-(5-(6-oxo-1,6-dihydropyridin-3-yl)oxazol-2-ylami...)Show SMILES NS(=O)(=O)c1ccc(Nc2ncc(o2)-c2ccc(=O)[nH]c2)cc1 Show InChI InChI=1S/C14H12N4O4S/c15-23(20,21)11-4-2-10(3-5-11)18-14-17-8-12(22-14)9-1-6-13(19)16-7-9/h1-8H,(H,16,19)(H,17,18)(H2,15,20,21) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of KDR by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
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