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PubMed code 20965724

Compile data set for download or QSAR
Found 57 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM50331277
PNG
(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Show SMILES COc1ccc2cc([nH]c2c1)-c1n[nH]c2cccnc12
Show InChI InChI=1S/C15H12N4O/c1-20-10-5-4-9-7-13(17-12(9)8-10)15-14-11(18-19-15)3-2-6-16-14/h2-8,17H,1H3,(H,18,19)
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n/an/a 60n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assay


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50331277
PNG
(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Show SMILES COc1ccc2cc([nH]c2c1)-c1n[nH]c2cccnc12
Show InChI InChI=1S/C15H12N4O/c1-20-10-5-4-9-7-13(17-12(9)8-10)15-14-11(18-19-15)3-2-6-16-14/h2-8,17H,1H3,(H,18,19)
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n/an/a 60n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of FLT3


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM50331280
PNG
(3-(6-methyl-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyrid...)
Show SMILES Cc1ccc2cc([nH]c2c1)-c1n[nH]c2cccnc12
Show InChI InChI=1S/C15H12N4/c1-9-4-5-10-8-13(17-12(10)7-9)15-14-11(18-19-15)3-2-6-16-14/h2-8,17H,1H3,(H,18,19)
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n/an/a 70n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assay


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM50331273
PNG
(3-(6-methyl-1H-indol-2-yl)-1H-indazole-6-carbonitr...)
Show SMILES Cc1ccc2cc([nH]c2c1)-c1n[nH]c2cc(ccc12)C#N
Show InChI InChI=1S/C17H12N4/c1-10-2-4-12-8-16(19-14(12)6-10)17-13-5-3-11(9-18)7-15(13)20-21-17/h2-8,19H,1H3,(H,20,21)
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n/an/a 70n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assay


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM50331268
PNG
(3-(1H-indol-2-yl)-1H-indazole-5-carbonitrile | CHE...)
Show SMILES N#Cc1ccc2[nH]nc(-c3cc4ccccc4[nH]3)c2c1
Show InChI InChI=1S/C16H10N4/c17-9-10-5-6-14-12(7-10)16(20-19-14)15-8-11-3-1-2-4-13(11)18-15/h1-8,18H,(H,19,20)
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n/an/a 80n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assay


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM50331269
PNG
(3-(1H-indol-2-yl)-1H-indazole-6-carbonitrile | CHE...)
Show SMILES N#Cc1ccc2c(n[nH]c2c1)-c1cc2ccccc2[nH]1
Show InChI InChI=1S/C16H10N4/c17-9-10-5-6-12-14(7-10)19-20-16(12)15-8-11-3-1-2-4-13(11)18-15/h1-8,18H,(H,19,20)
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n/an/a 80n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assay


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM50331274
PNG
(6-fluoro-3-(6-methoxy-1H-indol-2-yl)-1H-indazole |...)
Show SMILES COc1ccc2cc([nH]c2c1)-c1n[nH]c2cc(F)ccc12
Show InChI InChI=1S/C16H12FN3O/c1-21-11-4-2-9-6-15(18-13(9)8-11)16-12-5-3-10(17)7-14(12)19-20-16/h2-8,18H,1H3,(H,19,20)
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Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assay


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM50331271
PNG
(6-methyl-3-(6-methyl-1H-indol-2-yl)-1H-indazole | ...)
Show SMILES Cc1ccc2cc([nH]c2c1)-c1n[nH]c2cc(C)ccc12
Show InChI InChI=1S/C17H15N3/c1-10-3-5-12-9-16(18-14(12)7-10)17-13-6-4-11(2)8-15(13)19-20-17/h3-9,18H,1-2H3,(H,19,20)
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n/an/a 90n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assay


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM50331262
PNG
(3-(6-methyl-1H-indol-2-yl)-1H-indazole | CHEMBL128...)
Show SMILES Cc1ccc2cc([nH]c2c1)-c1n[nH]c2ccccc12
Show InChI InChI=1S/C16H13N3/c1-10-6-7-11-9-15(17-14(11)8-10)16-12-4-2-3-5-13(12)18-19-16/h2-9,17H,1H3,(H,18,19)
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n/an/a 110n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assay


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM50331258
PNG
(3-(5-methoxy-1H-indol-2-yl)-1H-indazole | CHEMBL12...)
Show SMILES COc1ccc2[nH]c(cc2c1)-c1n[nH]c2ccccc12
Show InChI InChI=1S/C16H13N3O/c1-20-11-6-7-13-10(8-11)9-15(17-13)16-12-4-2-3-5-14(12)18-19-16/h2-9,17H,1H3,(H,18,19)
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Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assay


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM50331259
PNG
(3-(6-methoxy-1H-indol-2-yl)-1H-indazole | CHEMBL12...)
Show SMILES COc1ccc2cc([nH]c2c1)-c1n[nH]c2ccccc12
Show InChI InChI=1S/C16H13N3O/c1-20-11-7-6-10-8-15(17-14(10)9-11)16-12-4-2-3-5-13(12)18-19-16/h2-9,17H,1H3,(H,18,19)
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n/an/a 130n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assay


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM50331257
PNG
(3-(1H-indol-2-yl)-1H-indazole | CHEMBL1288974)
Show SMILES c1c([nH]c2ccccc12)-c1n[nH]c2ccccc12
Show InChI InChI=1S/C15H11N3/c1-3-7-12-10(5-1)9-14(16-12)15-11-6-2-4-8-13(11)17-18-15/h1-9,16H,(H,17,18)
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n/an/a 140n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assay


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM50331272
PNG
(6-fluoro-3-(6-methyl-1H-indol-2-yl)-1H-indazole | ...)
Show SMILES Cc1ccc2cc([nH]c2c1)-c1n[nH]c2cc(F)ccc12
Show InChI InChI=1S/C16H12FN3/c1-9-2-3-10-7-15(18-13(10)6-9)16-12-5-4-11(17)8-14(12)19-20-16/h2-8,18H,1H3,(H,19,20)
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Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assay


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM50331265
PNG
(3-(1H-indol-2-yl)-6-methyl-1H-indazole | CHEMBL128...)
Show SMILES Cc1ccc2c(n[nH]c2c1)-c1cc2ccccc2[nH]1
Show InChI InChI=1S/C16H13N3/c1-10-6-7-12-14(8-10)18-19-16(12)15-9-11-4-2-3-5-13(11)17-15/h2-9,17H,1H3,(H,18,19)
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n/an/a 160n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assay


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM50331266
PNG
(5-fluoro-3-(1H-indol-2-yl)-1H-indazole | CHEMBL128...)
Show SMILES Fc1ccc2[nH]nc(-c3cc4ccccc4[nH]3)c2c1
Show InChI InChI=1S/C15H10FN3/c16-10-5-6-13-11(8-10)15(19-18-13)14-7-9-3-1-2-4-12(9)17-14/h1-8,17H,(H,18,19)
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Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assay


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50331277
PNG
(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Show SMILES COc1ccc2cc([nH]c2c1)-c1n[nH]c2cccnc12
Show InChI InChI=1S/C15H12N4O/c1-20-10-5-4-9-7-13(17-12(9)8-10)15-14-11(18-19-15)3-2-6-16-14/h2-8,17H,1H3,(H,18,19)
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Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of Aurora A


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM50331267
PNG
(6-fluoro-3-(1H-indol-2-yl)-1H-indazole | CHEMBL128...)
Show SMILES Fc1ccc2c(n[nH]c2c1)-c1cc2ccccc2[nH]1
Show InChI InChI=1S/C15H10FN3/c16-10-5-6-11-13(8-10)18-19-15(11)14-7-9-3-1-2-4-12(9)17-14/h1-8,17H,(H,18,19)
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Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assay


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM50331275
PNG
(3-(1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyridine | CHE...)
Show SMILES c1c([nH]c2ccccc12)-c1n[nH]c2cccnc12
Show InChI InChI=1S/C14H10N4/c1-2-5-10-9(4-1)8-12(16-10)14-13-11(17-18-14)6-3-7-15-13/h1-8,16H,(H,17,18)
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Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assay


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM50331282
PNG
(3-(6-bromo-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyridi...)
Show SMILES Brc1ccc2cc([nH]c2c1)-c1n[nH]c2cccnc12
Show InChI InChI=1S/C14H9BrN4/c15-9-4-3-8-6-12(17-11(8)7-9)14-13-10(18-19-14)2-1-5-16-13/h1-7,17H,(H,18,19)
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n/an/a 230n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assay


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM50331281
PNG
(3-(4-bromo-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyridi...)
Show SMILES Brc1cccc2[nH]c(cc12)-c1n[nH]c2cccnc12
Show InChI InChI=1S/C14H9BrN4/c15-9-3-1-4-10-8(9)7-12(17-10)14-13-11(18-19-14)5-2-6-16-13/h1-7,17H,(H,18,19)
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n/an/a 240n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assay


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM50331264
PNG
(3-(1H-indol-2-yl)-5-methyl-1H-indazole | CHEMBL128...)
Show SMILES Cc1ccc2[nH]nc(-c3cc4ccccc4[nH]3)c2c1
Show InChI InChI=1S/C16H13N3/c1-10-6-7-14-12(8-10)16(19-18-14)15-9-11-4-2-3-5-13(11)17-15/h2-9,17H,1H3,(H,18,19)
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n/an/a 250n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assay


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50331277
PNG
(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Show SMILES COc1ccc2cc([nH]c2c1)-c1n[nH]c2cccnc12
Show InChI InChI=1S/C15H12N4O/c1-20-10-5-4-9-7-13(17-12(9)8-10)15-14-11(18-19-15)3-2-6-16-14/h2-8,17H,1H3,(H,18,19)
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n/an/a 270n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of Aurora B


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM50331276
PNG
(3-(5-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Show SMILES COc1ccc2[nH]c(cc2c1)-c1n[nH]c2cccnc12
Show InChI InChI=1S/C15H12N4O/c1-20-10-4-5-11-9(7-10)8-13(17-11)15-14-12(18-19-15)3-2-6-16-14/h2-8,17H,1H3,(H,18,19)
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n/an/a 280n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assay


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM50331279
PNG
(3-(5-methyl-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyrid...)
Show SMILES Cc1ccc2[nH]c(cc2c1)-c1n[nH]c2cccnc12
Show InChI InChI=1S/C15H12N4/c1-9-4-5-11-10(7-9)8-13(17-11)15-14-12(18-19-15)3-2-6-16-14/h2-8,17H,1H3,(H,18,19)
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n/an/a 300n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assay


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50331277
PNG
(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Show SMILES COc1ccc2cc([nH]c2c1)-c1n[nH]c2cccnc12
Show InChI InChI=1S/C15H12N4O/c1-20-10-5-4-9-7-13(17-12(9)8-10)15-14-11(18-19-15)3-2-6-16-14/h2-8,17H,1H3,(H,18,19)
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n/an/a 310n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM50331270
PNG
(5-methyl-3-(6-methyl-1H-indol-2-yl)-1H-indazole | ...)
Show SMILES Cc1ccc2cc([nH]c2c1)-c1n[nH]c2ccc(C)cc12
Show InChI InChI=1S/C17H15N3/c1-10-4-6-14-13(7-10)17(20-19-14)16-9-12-5-3-11(2)8-15(12)18-16/h3-9,18H,1-2H3,(H,19,20)
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n/an/a 310n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assay


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM50331261
PNG
(3-(5-methyl-1H-indol-2-yl)-1H-indazole | CHEMBL128...)
Show SMILES Cc1ccc2[nH]c(cc2c1)-c1n[nH]c2ccccc12
Show InChI InChI=1S/C16H13N3/c1-10-6-7-13-11(8-10)9-15(17-13)16-12-4-2-3-5-14(12)18-19-16/h2-9,17H,1H3,(H,18,19)
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n/an/a 350n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assay


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50331277
PNG
(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Show SMILES COc1ccc2cc([nH]c2c1)-c1n[nH]c2cccnc12
Show InChI InChI=1S/C15H12N4O/c1-20-10-5-4-9-7-13(17-12(9)8-10)15-14-11(18-19-15)3-2-6-16-14/h2-8,17H,1H3,(H,18,19)
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n/an/a 1.31E+3n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of SRC


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 4 (CDK4)


(Homo sapiens (Human))
BDBM50331277
PNG
(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Show SMILES COc1ccc2cc([nH]c2c1)-c1n[nH]c2cccnc12
Show InChI InChI=1S/C15H12N4O/c1-20-10-5-4-9-7-13(17-12(9)8-10)15-14-11(18-19-15)3-2-6-16-14/h2-8,17H,1H3,(H,18,19)
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n/an/a 1.45E+3n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of CDK4/Cyclin D1


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50331277
PNG
(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Show SMILES COc1ccc2cc([nH]c2c1)-c1n[nH]c2cccnc12
Show InChI InChI=1S/C15H12N4O/c1-20-10-5-4-9-7-13(17-12(9)8-10)15-14-11(18-19-15)3-2-6-16-14/h2-8,17H,1H3,(H,18,19)
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n/an/a 2.45E+3n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of MEK-1


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50331283
PNG
(CHEMBL1288651 | N-(4-methoxyphenyl)-1H-indazole-3-...)
Show SMILES COc1ccc(NC(=O)c2n[nH]c3ccccc23)cc1
Show InChI InChI=1S/C15H13N3O2/c1-20-11-8-6-10(7-9-11)16-15(19)14-12-4-2-3-5-13(12)17-18-14/h2-9H,1H3,(H,16,19)(H,17,18)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of CDK2


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50331277
PNG
(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Show SMILES COc1ccc2cc([nH]c2c1)-c1n[nH]c2cccnc12
Show InChI InChI=1S/C15H12N4O/c1-20-10-5-4-9-7-13(17-12(9)8-10)15-14-11(18-19-15)3-2-6-16-14/h2-8,17H,1H3,(H,18,19)
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n/an/a 3.20E+3n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of PDGFR-beta


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Nek2


(Homo sapiens (Human))
BDBM50331277
PNG
(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Show SMILES COc1ccc2cc([nH]c2c1)-c1n[nH]c2cccnc12
Show InChI InChI=1S/C15H12N4O/c1-20-10-5-4-9-7-13(17-12(9)8-10)15-14-11(18-19-15)3-2-6-16-14/h2-8,17H,1H3,(H,18,19)
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n/an/a 3.22E+3n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of NEK-2


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM50331277
PNG
(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Show SMILES COc1ccc2cc([nH]c2c1)-c1n[nH]c2cccnc12
Show InChI InChI=1S/C15H12N4O/c1-20-10-5-4-9-7-13(17-12(9)8-10)15-14-11(18-19-15)3-2-6-16-14/h2-8,17H,1H3,(H,18,19)
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n/an/a 3.82E+3n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of SAK


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM50331263
PNG
(2-(1H-indazol-3-yl)-1H-indole-6-carboxylic acid | ...)
Show SMILES OC(=O)c1ccc2cc([nH]c2c1)-c1n[nH]c2ccccc12
Show InChI InChI=1S/C16H11N3O2/c20-16(21)10-6-5-9-7-14(17-13(9)8-10)15-11-3-1-2-4-12(11)18-19-15/h1-8,17H,(H,18,19)(H,20,21)
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n/an/a 3.98E+3n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assay


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50331277
PNG
(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Show SMILES COc1ccc2cc([nH]c2c1)-c1n[nH]c2cccnc12
Show InChI InChI=1S/C15H12N4O/c1-20-10-5-4-9-7-13(17-12(9)8-10)15-14-11(18-19-15)3-2-6-16-14/h2-8,17H,1H3,(H,18,19)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of CDK2


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens (Human))
BDBM50331277
PNG
(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Show SMILES COc1ccc2cc([nH]c2c1)-c1n[nH]c2cccnc12
Show InChI InChI=1S/C15H12N4O/c1-20-10-5-4-9-7-13(17-12(9)8-10)15-14-11(18-19-15)3-2-6-16-14/h2-8,17H,1H3,(H,18,19)
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n/an/a 5.23E+3n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of CDK1/Cyclin B


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
CDK2/Cyclin A/Cyclin A1


(Homo sapiens (Human))
BDBM50331277
PNG
(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Show SMILES COc1ccc2cc([nH]c2c1)-c1n[nH]c2cccnc12
Show InChI InChI=1S/C15H12N4O/c1-20-10-5-4-9-7-13(17-12(9)8-10)15-14-11(18-19-15)3-2-6-16-14/h2-8,17H,1H3,(H,18,19)
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n/an/a 5.38E+3n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin A


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50331277
PNG
(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Show SMILES COc1ccc2cc([nH]c2c1)-c1n[nH]c2cccnc12
Show InChI InChI=1S/C15H12N4O/c1-20-10-5-4-9-7-13(17-12(9)8-10)15-14-11(18-19-15)3-2-6-16-14/h2-8,17H,1H3,(H,18,19)
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n/an/a 5.49E+3n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of FAK


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50331277
PNG
(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Show SMILES COc1ccc2cc([nH]c2c1)-c1n[nH]c2cccnc12
Show InChI InChI=1S/C15H12N4O/c1-20-10-5-4-9-7-13(17-12(9)8-10)15-14-11(18-19-15)3-2-6-16-14/h2-8,17H,1H3,(H,18,19)
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n/an/a 5.72E+3n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of WEE1


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))
BDBM50331277
PNG
(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Show SMILES COc1ccc2cc([nH]c2c1)-c1n[nH]c2cccnc12
Show InChI InChI=1S/C15H12N4O/c1-20-10-5-4-9-7-13(17-12(9)8-10)15-14-11(18-19-15)3-2-6-16-14/h2-8,17H,1H3,(H,18,19)
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n/an/a 5.94E+3n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of CHK1


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (Human))
BDBM50331277
PNG
(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Show SMILES COc1ccc2cc([nH]c2c1)-c1n[nH]c2cccnc12
Show InChI InChI=1S/C15H12N4O/c1-20-10-5-4-9-7-13(17-12(9)8-10)15-14-11(18-19-15)3-2-6-16-14/h2-8,17H,1H3,(H,18,19)
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n/an/a 7.41E+3n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of CDK5/p25


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM50331277
PNG
(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Show SMILES COc1ccc2cc([nH]c2c1)-c1n[nH]c2cccnc12
Show InChI InChI=1S/C15H12N4O/c1-20-10-5-4-9-7-13(17-12(9)8-10)15-14-11(18-19-15)3-2-6-16-14/h2-8,17H,1H3,(H,18,19)
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n/an/a 7.68E+3n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of ABL1


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM50331277
PNG
(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Show SMILES COc1ccc2cc([nH]c2c1)-c1n[nH]c2cccnc12
Show InChI InChI=1S/C15H12N4O/c1-20-10-5-4-9-7-13(17-12(9)8-10)15-14-11(18-19-15)3-2-6-16-14/h2-8,17H,1H3,(H,18,19)
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n/an/a 8.75E+3n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of TTK


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM50331260
PNG
(3-(7-methoxy-1H-indol-2-yl)-1H-indazole | CHEMBL12...)
Show SMILES COc1cccc2cc([nH]c12)-c1n[nH]c2ccccc12
Show InChI InChI=1S/C16H13N3O/c1-20-14-8-4-5-10-9-13(17-15(10)14)16-11-6-2-3-7-12(11)18-19-16/h2-9,17H,1H3,(H,18,19)
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n/an/a 2.20E+4n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assay


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50331277
PNG
(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Show SMILES COc1ccc2cc([nH]c2c1)-c1n[nH]c2cccnc12
Show InChI InChI=1S/C15H12N4O/c1-20-10-5-4-9-7-13(17-12(9)8-10)15-14-11(18-19-15)3-2-6-16-14/h2-8,17H,1H3,(H,18,19)
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n/an/a 2.24E+4n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of PKC-theta


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM50331278
PNG
(3-(7-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Show SMILES COc1cccc2cc([nH]c12)-c1n[nH]c2cccnc12
Show InChI InChI=1S/C15H12N4O/c1-20-12-6-2-4-9-8-11(17-13(9)12)15-14-10(18-19-15)5-3-7-16-14/h2-8,17H,1H3,(H,18,19)
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n/an/a 2.70E+4n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assay


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM50331277
PNG
(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Show SMILES COc1ccc2cc([nH]c2c1)-c1n[nH]c2cccnc12
Show InChI InChI=1S/C15H12N4O/c1-20-10-5-4-9-7-13(17-12(9)8-10)15-14-11(18-19-15)3-2-6-16-14/h2-8,17H,1H3,(H,18,19)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of PLK1


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
p21-Activated kinase 2 (PAK2)


(Homo sapiens (Human))
BDBM50331277
PNG
(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Show SMILES COc1ccc2cc([nH]c2c1)-c1n[nH]c2cccnc12
Show InChI InChI=1S/C15H12N4O/c1-20-10-5-4-9-7-13(17-12(9)8-10)15-14-11(18-19-15)3-2-6-16-14/h2-8,17H,1H3,(H,18,19)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of PAK2


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (Human))
BDBM50331277
PNG
(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Show SMILES COc1ccc2cc([nH]c2c1)-c1n[nH]c2cccnc12
Show InChI InChI=1S/C15H12N4O/c1-20-10-5-4-9-7-13(17-12(9)8-10)15-14-11(18-19-15)3-2-6-16-14/h2-8,17H,1H3,(H,18,19)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of PKC-beta1


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase MRCK beta


(Homo sapiens (Human))
BDBM50331277
PNG
(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Show SMILES COc1ccc2cc([nH]c2c1)-c1n[nH]c2cccnc12
Show InChI InChI=1S/C15H12N4O/c1-20-10-5-4-9-7-13(17-12(9)8-10)15-14-11(18-19-15)3-2-6-16-14/h2-8,17H,1H3,(H,18,19)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of CDC42 BpB


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50331277
PNG
(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Show SMILES COc1ccc2cc([nH]c2c1)-c1n[nH]c2cccnc12
Show InChI InChI=1S/C15H12N4O/c1-20-10-5-4-9-7-13(17-12(9)8-10)15-14-11(18-19-15)3-2-6-16-14/h2-8,17H,1H3,(H,18,19)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of p38-alpha


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Death-associated protein kinase 1


(Homo sapiens (Human))
BDBM50331277
PNG
(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Show SMILES COc1ccc2cc([nH]c2c1)-c1n[nH]c2cccnc12
Show InChI InChI=1S/C15H12N4O/c1-20-10-5-4-9-7-13(17-12(9)8-10)15-14-11(18-19-15)3-2-6-16-14/h2-8,17H,1H3,(H,18,19)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of DAPK1


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (Human))
BDBM50331277
PNG
(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Show SMILES COc1ccc2cc([nH]c2c1)-c1n[nH]c2cccnc12
Show InChI InChI=1S/C15H12N4O/c1-20-10-5-4-9-7-13(17-12(9)8-10)15-14-11(18-19-15)3-2-6-16-14/h2-8,17H,1H3,(H,18,19)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of IKK-beta


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
Casein kinase II alpha


(Homo sapiens (Human))
BDBM50331277
PNG
(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Show SMILES COc1ccc2cc([nH]c2c1)-c1n[nH]c2cccnc12
Show InChI InChI=1S/C15H12N4O/c1-20-10-5-4-9-7-13(17-12(9)8-10)15-14-11(18-19-15)3-2-6-16-14/h2-8,17H,1H3,(H,18,19)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of CK2-alpha1


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
PDZ-binding kinase


(Homo sapiens (Human))
BDBM50331277
PNG
(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Show SMILES COc1ccc2cc([nH]c2c1)-c1n[nH]c2cccnc12
Show InChI InChI=1S/C15H12N4O/c1-20-10-5-4-9-7-13(17-12(9)8-10)15-14-11(18-19-15)3-2-6-16-14/h2-8,17H,1H3,(H,18,19)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of PBK


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM50331277
PNG
(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Show SMILES COc1ccc2cc([nH]c2c1)-c1n[nH]c2cccnc12
Show InChI InChI=1S/C15H12N4O/c1-20-10-5-4-9-7-13(17-12(9)8-10)15-14-11(18-19-15)3-2-6-16-14/h2-8,17H,1H3,(H,18,19)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of B-raf


Bioorg Med Chem Lett 20: 6998-7003 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.119
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%