Found 99 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331461
(1-Trifluoromethyl-cyclopropanecarboxylic acid{3-[(...)Show SMILES CC(C)(CNC(=O)C1(CC1)C(F)(F)F)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:17| Show InChI InChI=1S/C23H23F4N3O3S/c1-21(2,13-28-20(31)22(10-11-22)23(25,26)27)14-30(16-6-4-3-5-7-16)19-17-9-8-15(24)12-18(17)34(32,33)29-19/h3-9,12H,10-11,13-14H2,1-2H3,(H,28,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331462
(1-Trifluoromethyl-cyclobutanecarboxylic acid{3-[(6...)Show SMILES CC(C)(CNC(=O)C1(CCC1)C(F)(F)F)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:18| Show InChI InChI=1S/C24H25F4N3O3S/c1-22(2,14-29-21(32)23(11-6-12-23)24(26,27)28)15-31(17-7-4-3-5-8-17)20-18-10-9-16(25)13-19(18)35(33,34)30-20/h3-5,7-10,13H,6,11-12,14-15H2,1-2H3,(H,29,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331463
(2,2-Difluoro-cyclopropanecarboxylic acid{3-[(6-flu...)Show SMILES CC(C)(CNC(=O)C1CC1(F)F)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:15| Show InChI InChI=1S/C22H22F3N3O3S/c1-21(2,12-26-20(29)17-11-22(17,24)25)13-28(15-6-4-3-5-7-15)19-16-9-8-14(23)10-18(16)32(30,31)27-19/h3-10,17H,11-13H2,1-2H3,(H,26,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331465
(CHEMBL1290510 | Furan-3-carboxylic acid{3-[(6-fluo...)Show SMILES CC(C)(CNC(=O)c1ccoc1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:15| Show InChI InChI=1S/C23H22FN3O4S/c1-23(2,14-25-22(28)16-10-11-31-13-16)15-27(18-6-4-3-5-7-18)21-19-9-8-17(24)12-20(19)32(29,30)26-21/h3-13H,14-15H2,1-2H3,(H,25,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331464
(3,3,3-Trifluoro-N-{3-[(6-fluoro-1,1-dioxo-1H-1lamb...)Show SMILES CC(C)(CNC(=O)CC(F)(F)F)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:14| Show InChI InChI=1S/C21H21F4N3O3S/c1-20(2,12-26-18(29)11-21(23,24)25)13-28(15-6-4-3-5-7-15)19-16-9-8-14(22)10-17(16)32(30,31)27-19/h3-10H,11-13H2,1-2H3,(H,26,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331466
(CHEMBL1290169 | N-{3-[(1,1-Dioxo-1H-1lambda*6*-ben...)Show SMILES CC(C)(CNC(=O)c1ccc(F)cc1)CN(C1=NS(=O)(=O)c2ccccc12)c1ccccc1 |t:17| Show InChI InChI=1S/C25H24FN3O3S/c1-25(2,16-27-24(30)18-12-14-19(26)15-13-18)17-29(20-8-4-3-5-9-20)23-21-10-6-7-11-22(21)33(31,32)28-23/h3-15H,16-17H2,1-2H3,(H,27,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331468
(CHEMBL1290509 | Furan-2-carboxylic acid{3-[(6-fluo...)Show SMILES CC(C)(CNC(=O)c1ccco1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:15| Show InChI InChI=1S/C23H22FN3O4S/c1-23(2,14-25-22(28)19-9-6-12-31-19)15-27(17-7-4-3-5-8-17)21-18-11-10-16(24)13-20(18)32(29,30)26-21/h3-13H,14-15H2,1-2H3,(H,25,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331469
(CHEMBL1289300 | N-{3-[(6-Fluoro-1,1-dioxo-1H-1lamb...)Show SMILES COc1cnccc1C(=O)NCC(C)(C)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:18| Show InChI InChI=1S/C25H25FN4O4S/c1-25(2,15-28-24(31)19-11-12-27-14-21(19)34-3)16-30(18-7-5-4-6-8-18)23-20-10-9-17(26)13-22(20)35(32,33)29-23/h4-14H,15-16H2,1-3H3,(H,28,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331467
(1-Methyl-cyclopropanecarboxylic acid{3-[(6-fluoro-...)Show SMILES CC(C)(CNC(=O)C1(C)CC1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:14| Show InChI InChI=1S/C23H26FN3O3S/c1-22(2,14-25-21(28)23(3)11-12-23)15-27(17-7-5-4-6-8-17)20-18-10-9-16(24)13-19(18)31(29,30)26-20/h4-10,13H,11-12,14-15H2,1-3H3,(H,25,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331470
(CHEMBL1289188 | Pyrazine-2-carboxylic acid{3-[(6-f...)Show SMILES CC(C)(CNC(=O)c1cnccn1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:16| Show InChI InChI=1S/C23H22FN5O3S/c1-23(2,14-27-22(30)19-13-25-10-11-26-19)15-29(17-6-4-3-5-7-17)21-18-9-8-16(24)12-20(18)33(31,32)28-21/h3-13H,14-15H2,1-2H3,(H,27,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331461
(1-Trifluoromethyl-cyclopropanecarboxylic acid{3-[(...)Show SMILES CC(C)(CNC(=O)C1(CC1)C(F)(F)F)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:17| Show InChI InChI=1S/C23H23F4N3O3S/c1-21(2,13-28-20(31)22(10-11-22)23(25,26)27)14-30(16-6-4-3-5-7-16)19-17-9-8-15(24)12-18(17)34(32,33)29-19/h3-9,12H,10-11,13-14H2,1-2H3,(H,28,31) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331471
(3,3,3-Trifluoro-N-{3-[(6-fluoro-1,1-dioxo-1H-1lamb...)Show SMILES CC(C)(CNC(=O)C(C)(O)C(F)(F)F)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:16| Show InChI InChI=1S/C22H23F4N3O4S/c1-20(2,12-27-19(30)21(3,31)22(24,25)26)13-29(15-7-5-4-6-8-15)18-16-10-9-14(23)11-17(16)34(32,33)28-18/h4-11,31H,12-13H2,1-3H3,(H,27,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331464
(3,3,3-Trifluoro-N-{3-[(6-fluoro-1,1-dioxo-1H-1lamb...)Show SMILES CC(C)(CNC(=O)CC(F)(F)F)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:14| Show InChI InChI=1S/C21H21F4N3O3S/c1-20(2,12-26-18(29)11-21(23,24)25)13-28(15-6-4-3-5-7-15)19-16-9-8-14(22)10-17(16)32(30,31)27-19/h3-10H,11-13H2,1-2H3,(H,26,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331472
(CHEMBL1289068 | Cyclopropanecarboxylic acid{3-[(6-...)Show SMILES CC(C)(CNC(=O)C1CC1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:13| Show InChI InChI=1S/C22H24FN3O3S/c1-22(2,13-24-21(27)15-8-9-15)14-26(17-6-4-3-5-7-17)20-18-11-10-16(23)12-19(18)30(28,29)25-20/h3-7,10-12,15H,8-9,13-14H2,1-2H3,(H,24,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 280 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331473
(CHEMBL1290621 | Thiazole-4-carboxylic acid{3-[(6-f...)Show SMILES CC(C)(CNC(=O)c1cscn1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:15| Show InChI InChI=1S/C22H21FN4O3S2/c1-22(2,12-24-21(28)18-11-31-14-25-18)13-27(16-6-4-3-5-7-16)20-17-9-8-15(23)10-19(17)32(29,30)26-20/h3-11,14H,12-13H2,1-2H3,(H,24,28) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331474
(CHEMBL1290618 | Pyrrole-1-carboxylic acid{3-[(6-fl...)Show SMILES CC(C)(CNC(=O)n1cccc1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:15| Show InChI InChI=1S/C23H23FN4O3S/c1-23(2,15-25-22(29)27-12-6-7-13-27)16-28(18-8-4-3-5-9-18)21-19-11-10-17(24)14-20(19)32(30,31)26-21/h3-14H,15-16H2,1-2H3,(H,25,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331475
(3-Hydroxy-pyridine-2-carboxylic acid{3-[(6-fluoro-...)Show SMILES CC(C)(CNC(=O)c1ncccc1O)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:17| Show InChI InChI=1S/C24H23FN4O4S/c1-24(2,14-27-23(31)21-19(30)9-6-12-26-21)15-29(17-7-4-3-5-8-17)22-18-11-10-16(25)13-20(18)34(32,33)28-22/h3-13,30H,14-15H2,1-2H3,(H,27,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331463
(2,2-Difluoro-cyclopropanecarboxylic acid{3-[(6-flu...)Show SMILES CC(C)(CNC(=O)C1CC1(F)F)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:15| Show InChI InChI=1S/C22H22F3N3O3S/c1-21(2,12-26-20(29)17-11-22(17,24)25)13-28(15-6-4-3-5-7-15)19-16-9-8-14(23)10-18(16)32(30,31)27-19/h3-10,17H,11-13H2,1-2H3,(H,26,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331462
(1-Trifluoromethyl-cyclobutanecarboxylic acid{3-[(6...)Show SMILES CC(C)(CNC(=O)C1(CCC1)C(F)(F)F)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:18| Show InChI InChI=1S/C24H25F4N3O3S/c1-22(2,14-29-21(32)23(11-6-12-23)24(26,27)28)15-31(17-7-4-3-5-8-17)20-18-10-9-16(25)13-19(18)35(33,34)30-20/h3-5,7-10,13H,6,11-12,14-15H2,1-2H3,(H,29,32) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331476
(4-Cyano-tetrahydro-pyran-4-carboxylic acid{3-[(6-f...)Show SMILES CC(C)(CNC(=O)C1(CCOCC1)C#N)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:18| Show InChI InChI=1S/C25H27FN4O4S/c1-24(2,16-28-23(31)25(15-27)10-12-34-13-11-25)17-30(19-6-4-3-5-7-19)22-20-9-8-18(26)14-21(20)35(32,33)29-22/h3-9,14H,10-13,16-17H2,1-2H3,(H,28,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 330 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331474
(CHEMBL1290618 | Pyrrole-1-carboxylic acid{3-[(6-fl...)Show SMILES CC(C)(CNC(=O)n1cccc1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:15| Show InChI InChI=1S/C23H23FN4O3S/c1-23(2,15-25-22(29)27-12-6-7-13-27)16-28(18-8-4-3-5-9-18)21-19-11-10-17(24)14-20(19)32(30,31)26-21/h3-14H,15-16H2,1-2H3,(H,25,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331477
(CHEMBL1290280 | Morpholine-4-carboxylic acid{3-[(6...)Show SMILES CC(C)(CNC(=O)N1CCOCC1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:16| Show InChI InChI=1S/C23H27FN4O4S/c1-23(2,15-25-22(29)27-10-12-32-13-11-27)16-28(18-6-4-3-5-7-18)21-19-9-8-17(24)14-20(19)33(30,31)26-21/h3-9,14H,10-13,15-16H2,1-2H3,(H,25,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331478
(1-Cyano-cyclopropanecarboxylic acid{3-[(6-fluoro-1...)Show SMILES CC(C)(CNC(=O)C1(CC1)C#N)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:15| Show InChI InChI=1S/C23H23FN4O3S/c1-22(2,14-26-21(29)23(13-25)10-11-23)15-28(17-6-4-3-5-7-17)20-18-9-8-16(24)12-19(18)32(30,31)27-20/h3-9,12H,10-11,14-15H2,1-2H3,(H,26,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331470
(CHEMBL1289188 | Pyrazine-2-carboxylic acid{3-[(6-f...)Show SMILES CC(C)(CNC(=O)c1cnccn1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:16| Show InChI InChI=1S/C23H22FN5O3S/c1-23(2,14-27-22(30)19-13-25-10-11-26-19)15-29(17-6-4-3-5-7-17)21-18-9-8-16(24)12-20(18)33(31,32)28-21/h3-13H,14-15H2,1-2H3,(H,27,30) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331479
(1-Hydroxy-cyclohexanecarboxylic acid{3-[(6-fluoro-...)Show SMILES CC(C)(CNC(=O)C1(O)CCCCC1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:17| Show InChI InChI=1S/C25H30FN3O4S/c1-24(2,16-27-23(30)25(31)13-7-4-8-14-25)17-29(19-9-5-3-6-10-19)22-20-12-11-18(26)15-21(20)34(32,33)28-22/h3,5-6,9-12,15,31H,4,7-8,13-14,16-17H2,1-2H3,(H,27,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331480
(CHEMBL1289744 | Tetrahydro-furan-2-carboxylic acid...)Show SMILES CC(C)(CNC(=O)C1CCCO1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:15| Show InChI InChI=1S/C23H26FN3O4S/c1-23(2,14-25-22(28)19-9-6-12-31-19)15-27(17-7-4-3-5-8-17)21-18-11-10-16(24)13-20(18)32(29,30)26-21/h3-5,7-8,10-11,13,19H,6,9,12,14-15H2,1-2H3,(H,25,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331465
(CHEMBL1290510 | Furan-3-carboxylic acid{3-[(6-fluo...)Show SMILES CC(C)(CNC(=O)c1ccoc1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:15| Show InChI InChI=1S/C23H22FN3O4S/c1-23(2,14-25-22(28)16-10-11-31-13-16)15-27(18-6-4-3-5-7-18)21-19-9-8-17(24)12-20(19)32(29,30)26-21/h3-13H,14-15H2,1-2H3,(H,25,28) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331467
(1-Methyl-cyclopropanecarboxylic acid{3-[(6-fluoro-...)Show SMILES CC(C)(CNC(=O)C1(C)CC1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:14| Show InChI InChI=1S/C23H26FN3O3S/c1-22(2,14-25-21(28)23(3)11-12-23)15-27(17-7-5-4-6-8-17)20-18-10-9-16(24)13-19(18)31(29,30)26-20/h4-10,13H,11-12,14-15H2,1-3H3,(H,25,28) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331469
(CHEMBL1289300 | N-{3-[(6-Fluoro-1,1-dioxo-1H-1lamb...)Show SMILES COc1cnccc1C(=O)NCC(C)(C)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:18| Show InChI InChI=1S/C25H25FN4O4S/c1-25(2,15-28-24(31)19-11-12-27-14-21(19)34-3)16-30(18-7-5-4-6-8-18)23-20-10-9-17(26)13-22(20)35(32,33)29-23/h4-14H,15-16H2,1-3H3,(H,28,31) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331481
(4,4-Difluoro-1-hydroxy-cyclohexanecarboxylic acid{...)Show SMILES CC(C)(CNC(=O)C1(O)CCC(F)(F)CC1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:19| Show InChI InChI=1S/C25H28F3N3O4S/c1-23(2,15-29-22(32)24(33)10-12-25(27,28)13-11-24)16-31(18-6-4-3-5-7-18)21-19-9-8-17(26)14-20(19)36(34,35)30-21/h3-9,14,33H,10-13,15-16H2,1-2H3,(H,29,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 390 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331468
(CHEMBL1290509 | Furan-2-carboxylic acid{3-[(6-fluo...)Show SMILES CC(C)(CNC(=O)c1ccco1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:15| Show InChI InChI=1S/C23H22FN3O4S/c1-23(2,14-25-22(28)19-9-6-12-31-19)15-27(17-7-4-3-5-8-17)21-18-11-10-16(24)13-20(18)32(29,30)26-21/h3-13H,14-15H2,1-2H3,(H,25,28) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331482
(CHEMBL1290170 | N-{3-[(1,1-Dioxo-1H-1lambda*6*-ben...)Show SMILES CC(CNC(=O)c1ccc(F)cc1)CN(C1=NS(=O)(=O)c2ccccc12)c1ccccc1 |t:16| Show InChI InChI=1S/C24H22FN3O3S/c1-17(15-26-24(29)18-11-13-19(25)14-12-18)16-28(20-7-3-2-4-8-20)23-21-9-5-6-10-22(21)32(30,31)27-23/h2-14,17H,15-16H2,1H3,(H,26,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331483
(CHEMBL1289850 | Tetrahydro-pyran-2-carboxylic acid...)Show SMILES CC(C)(CNC(=O)C1CCCCO1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:16| Show InChI InChI=1S/C24H28FN3O4S/c1-24(2,15-26-23(29)20-10-6-7-13-32-20)16-28(18-8-4-3-5-9-18)22-19-12-11-17(25)14-21(19)33(30,31)27-22/h3-5,8-9,11-12,14,20H,6-7,10,13,15-16H2,1-2H3,(H,26,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331479
(1-Hydroxy-cyclohexanecarboxylic acid{3-[(6-fluoro-...)Show SMILES CC(C)(CNC(=O)C1(O)CCCCC1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:17| Show InChI InChI=1S/C25H30FN3O4S/c1-24(2,16-27-23(30)25(31)13-7-4-8-14-25)17-29(19-9-5-3-6-10-19)22-20-12-11-18(26)15-21(20)34(32,33)28-22/h3,5-6,9-12,15,31H,4,7-8,13-14,16-17H2,1-2H3,(H,27,30) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331475
(3-Hydroxy-pyridine-2-carboxylic acid{3-[(6-fluoro-...)Show SMILES CC(C)(CNC(=O)c1ncccc1O)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:17| Show InChI InChI=1S/C24H23FN4O4S/c1-24(2,14-27-23(31)21-19(30)9-6-12-26-21)15-29(17-7-4-3-5-8-17)22-18-11-10-16(25)13-20(18)34(32,33)28-22/h3-13,30H,14-15H2,1-2H3,(H,27,31) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 460 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331485
(CHEMBL1290279 | Morpholine-4-carboxylic acid{3-[(1...)Show SMILES CC(C)(CNC(=O)N1CCOCC1)CN(C1=NS(=O)(=O)c2ccccc12)c1ccccc1 |t:16| Show InChI InChI=1S/C23H28N4O4S/c1-23(2,16-24-22(28)26-12-14-31-15-13-26)17-27(18-8-4-3-5-9-18)21-19-10-6-7-11-20(19)32(29,30)25-21/h3-11H,12-17H2,1-2H3,(H,24,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 470 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331484
(1-Hydroxy-cyclopentanecarboxylic acid{3-[(6-fluoro...)Show SMILES CC(C)(CNC(=O)C1(O)CCCC1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:16| Show InChI InChI=1S/C24H28FN3O4S/c1-23(2,15-26-22(29)24(30)12-6-7-13-24)16-28(18-8-4-3-5-9-18)21-19-11-10-17(25)14-20(19)33(31,32)27-21/h3-5,8-11,14,30H,6-7,12-13,15-16H2,1-2H3,(H,26,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 470 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331471
(3,3,3-Trifluoro-N-{3-[(6-fluoro-1,1-dioxo-1H-1lamb...)Show SMILES CC(C)(CNC(=O)C(C)(O)C(F)(F)F)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:16| Show InChI InChI=1S/C22H23F4N3O4S/c1-20(2,12-27-19(30)21(3,31)22(24,25)26)13-29(15-7-5-4-6-8-15)18-16-10-9-14(23)11-17(16)34(32,33)28-18/h4-11,31H,12-13H2,1-3H3,(H,27,30) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 480 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331472
(CHEMBL1289068 | Cyclopropanecarboxylic acid{3-[(6-...)Show SMILES CC(C)(CNC(=O)C1CC1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:13| Show InChI InChI=1S/C22H24FN3O3S/c1-22(2,13-24-21(27)15-8-9-15)14-26(17-6-4-3-5-7-17)20-18-11-10-16(23)12-19(18)30(28,29)25-20/h3-7,10-12,15H,8-9,13-14H2,1-2H3,(H,24,27) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 490 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331486
(1-Methyl-1H-imidazole-2-carboxylic acid{3-[(6-fluo...)Show SMILES Cn1ccnc1C(=O)NCC(C)(C)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:16| Show InChI InChI=1S/C23H24FN5O3S/c1-23(2,14-26-22(30)21-25-11-12-28(21)3)15-29(17-7-5-4-6-8-17)20-18-10-9-16(24)13-19(18)33(31,32)27-20/h4-13H,14-15H2,1-3H3,(H,26,30) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 520 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331488
(CHEMBL1290508 | Tetrahydro-pyran-4-carboxylic acid...)Show SMILES CC(C)(CNC(=O)C1CCOCC1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:16| Show InChI InChI=1S/C24H28FN3O4S/c1-24(2,15-26-23(29)17-10-12-32-13-11-17)16-28(19-6-4-3-5-7-19)22-20-9-8-18(25)14-21(20)33(30,31)27-22/h3-9,14,17H,10-13,15-16H2,1-2H3,(H,26,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 530 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331487
(1-Amino-cyclopropanecarboxylic acid{3-[(6-fluoro-1...)Show SMILES CC(C)(CNC(=O)C1(N)CC1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:14| Show InChI InChI=1S/C22H25FN4O3S/c1-21(2,13-25-20(28)22(24)10-11-22)14-27(16-6-4-3-5-7-16)19-17-9-8-15(23)12-18(17)31(29,30)26-19/h3-9,12H,10-11,13-14,24H2,1-2H3,(H,25,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 530 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331473
(CHEMBL1290621 | Thiazole-4-carboxylic acid{3-[(6-f...)Show SMILES CC(C)(CNC(=O)c1cscn1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:15| Show InChI InChI=1S/C22H21FN4O3S2/c1-22(2,12-24-21(28)18-11-31-14-25-18)13-27(16-6-4-3-5-7-16)20-17-9-8-15(23)10-19(17)32(29,30)26-20/h3-11,14H,12-13H2,1-2H3,(H,24,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 540 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331478
(1-Cyano-cyclopropanecarboxylic acid{3-[(6-fluoro-1...)Show SMILES CC(C)(CNC(=O)C1(CC1)C#N)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:15| Show InChI InChI=1S/C23H23FN4O3S/c1-22(2,14-26-21(29)23(13-25)10-11-23)15-28(17-6-4-3-5-7-17)20-18-9-8-16(24)12-19(18)32(30,31)27-20/h3-9,12H,10-11,14-15H2,1-2H3,(H,26,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 540 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331423
(CHEMBL1289183 | N-{3-[(1,1-Dioxo-1H-1lambda*6*-ben...)Show SMILES Fc1ccc(cc1)C(=O)NCCCN(C1=NS(=O)(=O)c2ccccc12)c1ccccc1 |t:15| Show InChI InChI=1S/C23H20FN3O3S/c24-18-13-11-17(12-14-18)23(28)25-15-6-16-27(19-7-2-1-3-8-19)22-20-9-4-5-10-21(20)31(29,30)26-22/h1-5,7-14H,6,15-16H2,(H,25,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331486
(1-Methyl-1H-imidazole-2-carboxylic acid{3-[(6-fluo...)Show SMILES Cn1ccnc1C(=O)NCC(C)(C)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:16| Show InChI InChI=1S/C23H24FN5O3S/c1-23(2,14-26-22(30)21-25-11-12-28(21)3)15-29(17-7-5-4-6-8-17)20-18-10-9-16(24)13-19(18)33(31,32)27-20/h4-13H,14-15H2,1-3H3,(H,26,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331476
(4-Cyano-tetrahydro-pyran-4-carboxylic acid{3-[(6-f...)Show SMILES CC(C)(CNC(=O)C1(CCOCC1)C#N)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:18| Show InChI InChI=1S/C25H27FN4O4S/c1-24(2,16-28-23(31)25(15-27)10-12-34-13-11-25)17-30(19-6-4-3-5-7-19)22-20-9-8-18(26)14-21(20)35(32,33)29-22/h3-9,14H,10-13,16-17H2,1-2H3,(H,28,31) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 560 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331489
(CHEMBL1290395 | N-{3-[(1,1-Dioxo-1H-1lambda*6*-ben...)Show SMILES CC(C)(CNC(=O)c1cccc(c1)C(F)(F)F)CN(C1=NS(=O)(=O)c2ccccc12)c1ccccc1 |t:20| Show InChI InChI=1S/C26H24F3N3O3S/c1-25(2,16-30-24(33)18-9-8-10-19(15-18)26(27,28)29)17-32(20-11-4-3-5-12-20)23-21-13-6-7-14-22(21)36(34,35)31-23/h3-15H,16-17H2,1-2H3,(H,30,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 560 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331481
(4,4-Difluoro-1-hydroxy-cyclohexanecarboxylic acid{...)Show SMILES CC(C)(CNC(=O)C1(O)CCC(F)(F)CC1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:19| Show InChI InChI=1S/C25H28F3N3O4S/c1-23(2,15-29-22(32)24(33)10-12-25(27,28)13-11-24)16-31(18-6-4-3-5-7-18)21-19-9-8-17(26)14-20(19)36(34,35)30-21/h3-9,14,33H,10-13,15-16H2,1-2H3,(H,29,32) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 630 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331483
(CHEMBL1289850 | Tetrahydro-pyran-2-carboxylic acid...)Show SMILES CC(C)(CNC(=O)C1CCCCO1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:16| Show InChI InChI=1S/C24H28FN3O4S/c1-24(2,15-26-23(29)20-10-6-7-13-32-20)16-28(18-8-4-3-5-9-18)22-19-12-11-17(25)14-21(19)33(30,31)27-22/h3-5,8-9,11-12,14,20H,6-7,10,13,15-16H2,1-2H3,(H,26,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 640 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331490
(CHEMBL1290396 | N-{3-[(6-Fluoro-1,1-dioxo-1H-1lamb...)Show SMILES CC(C)(CNC(=O)c1cccc(c1)C(F)(F)F)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:20| Show InChI InChI=1S/C26H23F4N3O3S/c1-25(2,15-31-24(34)17-7-6-8-18(13-17)26(28,29)30)16-33(20-9-4-3-5-10-20)23-21-12-11-19(27)14-22(21)37(35,36)32-23/h3-14H,15-16H2,1-2H3,(H,31,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331491
(CHEMBL1290507 | Tetrahydro-pyran-4-carboxylic acid...)Show SMILES CC(C)(CNC(=O)C1CCOCC1)CN(C1=NS(=O)(=O)c2ccccc12)c1ccccc1 |t:16| Show InChI InChI=1S/C24H29N3O4S/c1-24(2,16-25-23(28)18-12-14-31-15-13-18)17-27(19-8-4-3-5-9-19)22-20-10-6-7-11-21(20)32(29,30)26-22/h3-11,18H,12-17H2,1-2H3,(H,25,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331484
(1-Hydroxy-cyclopentanecarboxylic acid{3-[(6-fluoro...)Show SMILES CC(C)(CNC(=O)C1(O)CCCC1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:16| Show InChI InChI=1S/C24H28FN3O4S/c1-23(2,15-26-22(29)24(30)12-6-7-13-24)16-28(18-8-4-3-5-9-18)21-19-11-10-17(25)14-20(19)33(31,32)27-21/h3-5,8-11,14,30H,6-7,12-13,15-16H2,1-2H3,(H,26,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 730 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50279106
(4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one | ...)Show InChI InChI=1S/C21H18O5/c22-20-9-8-16-19(26-20)14-18-17(10-13-24-18)21(16)25-12-5-4-11-23-15-6-2-1-3-7-15/h1-3,6-10,13-14H,4-5,11-12H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 740 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331492
(CHEMBL1290739 | Oxazole-4-carboxylic acid{3-[(6-fl...)Show SMILES CC(C)(CNC(=O)c1cocn1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:15| Show InChI InChI=1S/C22H21FN4O4S/c1-22(2,12-24-21(28)18-11-31-14-25-18)13-27(16-6-4-3-5-7-16)20-17-9-8-15(23)10-19(17)32(29,30)26-20/h3-11,14H,12-13H2,1-2H3,(H,24,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 750 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331493
(CHEMBL1289851 | N-{3-[(6-Fluoro-1,1-dioxo-1H-1lamb...)Show SMILES CC(C)(CNC(=O)CC1CCCCO1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:17| Show InChI InChI=1S/C25H30FN3O4S/c1-25(2,16-27-23(30)15-20-10-6-7-13-33-20)17-29(19-8-4-3-5-9-19)24-21-12-11-18(26)14-22(21)34(31,32)28-24/h3-5,8-9,11-12,14,20H,6-7,10,13,15-17H2,1-2H3,(H,27,30) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 780 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331487
(1-Amino-cyclopropanecarboxylic acid{3-[(6-fluoro-1...)Show SMILES CC(C)(CNC(=O)C1(N)CC1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:14| Show InChI InChI=1S/C22H25FN4O3S/c1-21(2,13-25-20(28)22(24)10-11-22)14-27(16-6-4-3-5-7-16)19-17-9-8-15(23)12-18(17)31(29,30)26-19/h3-9,12H,10-11,13-14,24H2,1-2H3,(H,25,28) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 790 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331494
(1-Hydroxy-cyclopropanecarboxylic ac id{3-[(6-fluor...)Show SMILES CC(C)(CNC(=O)C1(O)CC1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:14| Show InChI InChI=1S/C22H24FN3O4S/c1-21(2,13-24-20(27)22(28)10-11-22)14-26(16-6-4-3-5-7-16)19-17-9-8-15(23)12-18(17)31(29,30)25-19/h3-9,12,28H,10-11,13-14H2,1-2H3,(H,24,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 820 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331480
(CHEMBL1289744 | Tetrahydro-furan-2-carboxylic acid...)Show SMILES CC(C)(CNC(=O)C1CCCO1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:15| Show InChI InChI=1S/C23H26FN3O4S/c1-23(2,14-25-22(28)19-9-6-12-31-19)15-27(17-7-4-3-5-8-17)21-18-11-10-16(24)13-20(18)32(29,30)26-21/h3-5,7-8,10-11,13,19H,6,9,12,14-15H2,1-2H3,(H,25,28) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 830 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331495
(3,3-Dimethyl-tetrahydro-pyran-4-carboxylic acid{3-...)Show SMILES CC(C)(CNC(=O)C1CCOCC1(C)C)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:18| Show InChI InChI=1S/C26H32FN3O4S/c1-25(2,15-28-24(31)21-12-13-34-17-26(21,3)4)16-30(19-8-6-5-7-9-19)23-20-11-10-18(27)14-22(20)35(32,33)29-23/h5-11,14,21H,12-13,15-17H2,1-4H3,(H,28,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 840 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331492
(CHEMBL1290739 | Oxazole-4-carboxylic acid{3-[(6-fl...)Show SMILES CC(C)(CNC(=O)c1cocn1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:15| Show InChI InChI=1S/C22H21FN4O4S/c1-22(2,12-24-21(28)18-11-31-14-25-18)13-27(16-6-4-3-5-7-16)20-17-9-8-15(23)10-19(17)32(29,30)26-20/h3-11,14H,12-13H2,1-2H3,(H,24,28) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331495
(3,3-Dimethyl-tetrahydro-pyran-4-carboxylic acid{3-...)Show SMILES CC(C)(CNC(=O)C1CCOCC1(C)C)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:18| Show InChI InChI=1S/C26H32FN3O4S/c1-25(2,15-28-24(31)21-12-13-34-17-26(21,3)4)16-30(19-8-6-5-7-9-19)23-20-11-10-18(27)14-22(20)35(32,33)29-23/h5-11,14,21H,12-13,15-17H2,1-4H3,(H,28,31) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 960 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331496
(4-Hydroxy-tetrahydro-pyran-4-carboxylic acid{3-[(6...)Show SMILES CC(C)(CNC(=O)C1(O)CCOCC1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:17| Show InChI InChI=1S/C24H28FN3O5S/c1-23(2,15-26-22(29)24(30)10-12-33-13-11-24)16-28(18-6-4-3-5-7-18)21-19-9-8-17(25)14-20(19)34(31,32)27-21/h3-9,14,30H,10-13,15-16H2,1-2H3,(H,26,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.07E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331497
(1H-Pyrrole-3-carboxylic acid{3-[(6-fluoro-1,1-diox...)Show SMILES CC(C)(CNC(=O)c1cc[nH]c1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:15| Show InChI InChI=1S/C23H23FN4O3S/c1-23(2,14-26-22(29)16-10-11-25-13-16)15-28(18-6-4-3-5-7-18)21-19-9-8-17(24)12-20(19)32(30,31)27-21/h3-13,25H,14-15H2,1-2H3,(H,26,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.15E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331498
(CHEMBL1290619 | N-{3-[(6-Fluoro-1,1-dioxo-1H-1lamb...)Show SMILES CC(=O)NCC(C)(C)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:10| Show InChI InChI=1S/C20H22FN3O3S/c1-14(25)22-12-20(2,3)13-24(16-7-5-4-6-8-16)19-17-10-9-15(21)11-18(17)28(26,27)23-19/h4-11H,12-13H2,1-3H3,(H,22,25) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.18E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331498
(CHEMBL1290619 | N-{3-[(6-Fluoro-1,1-dioxo-1H-1lamb...)Show SMILES CC(=O)NCC(C)(C)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:10| Show InChI InChI=1S/C20H22FN3O3S/c1-14(25)22-12-20(2,3)13-24(16-7-5-4-6-8-16)19-17-10-9-15(21)11-18(17)28(26,27)23-19/h4-11H,12-13H2,1-3H3,(H,22,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.18E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331499
(CHEMBL1290398 | Morpholine-3-carboxylic acid{3-[(6...)Show SMILES CC(C)(CNC(=O)C1COCCN1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:16| Show InChI InChI=1S/C23H27FN4O4S/c1-23(2,14-26-22(29)19-13-32-11-10-25-19)15-28(17-6-4-3-5-7-17)21-18-9-8-16(24)12-20(18)33(30,31)27-21/h3-9,12,19,25H,10-11,13-15H2,1-2H3,(H,26,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.26E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331497
(1H-Pyrrole-3-carboxylic acid{3-[(6-fluoro-1,1-diox...)Show SMILES CC(C)(CNC(=O)c1cc[nH]c1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:15| Show InChI InChI=1S/C23H23FN4O3S/c1-23(2,14-26-22(29)16-10-11-25-13-16)15-28(18-6-4-3-5-7-18)21-19-9-8-17(24)12-20(19)32(30,31)27-21/h3-13,25H,14-15H2,1-2H3,(H,26,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.32E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331493
(CHEMBL1289851 | N-{3-[(6-Fluoro-1,1-dioxo-1H-1lamb...)Show SMILES CC(C)(CNC(=O)CC1CCCCO1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:17| Show InChI InChI=1S/C25H30FN3O4S/c1-25(2,16-27-23(30)15-20-10-6-7-13-33-20)17-29(19-8-4-3-5-9-19)24-21-12-11-18(26)14-22(21)34(31,32)28-24/h3-5,8-9,11-12,14,20H,6-7,10,13,15-17H2,1-2H3,(H,27,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.35E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331494
(1-Hydroxy-cyclopropanecarboxylic ac id{3-[(6-fluor...)Show SMILES CC(C)(CNC(=O)C1(O)CC1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:14| Show InChI InChI=1S/C22H24FN3O4S/c1-21(2,13-24-20(27)22(28)10-11-22)14-26(16-6-4-3-5-7-16)19-17-9-8-15(23)12-18(17)31(29,30)25-19/h3-9,12,28H,10-11,13-14H2,1-2H3,(H,24,27) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.35E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331500
(CHEMBL1290064 | N-{3-[(6-Fluoro-1,1-dioxo-1H-1lamb...)Show SMILES Cn1cccc1CC(=O)NCC(C)(C)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:17| Show InChI InChI=1S/C25H27FN4O3S/c1-25(2,16-27-23(31)15-20-10-7-13-29(20)3)17-30(19-8-5-4-6-9-19)24-21-12-11-18(26)14-22(21)34(32,33)28-24/h4-14H,15-17H2,1-3H3,(H,27,31) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.39E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331501
(1-Amino-cyclopentanecarboxylic acid{3-[(6-fluoro-1...)Show SMILES CC(C)(CNC(=O)C1(N)CCCC1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:16| Show InChI InChI=1S/C24H29FN4O3S/c1-23(2,15-27-22(30)24(26)12-6-7-13-24)16-29(18-8-4-3-5-9-18)21-19-11-10-17(25)14-20(19)33(31,32)28-21/h3-5,8-11,14H,6-7,12-13,15-16,26H2,1-2H3,(H,27,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.51E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331496
(4-Hydroxy-tetrahydro-pyran-4-carboxylic acid{3-[(6...)Show SMILES CC(C)(CNC(=O)C1(O)CCOCC1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:17| Show InChI InChI=1S/C24H28FN3O5S/c1-23(2,15-26-22(29)24(30)10-12-33-13-11-24)16-28(18-6-4-3-5-7-18)21-19-9-8-17(25)14-20(19)34(31,32)27-21/h3-9,14,30H,10-13,15-16H2,1-2H3,(H,26,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331499
(CHEMBL1290398 | Morpholine-3-carboxylic acid{3-[(6...)Show SMILES CC(C)(CNC(=O)C1COCCN1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:16| Show InChI InChI=1S/C23H27FN4O4S/c1-23(2,14-26-22(29)19-13-32-11-10-25-19)15-28(17-6-4-3-5-7-17)21-18-9-8-16(24)12-20(18)33(30,31)27-21/h3-9,12,19,25H,10-11,13-15H2,1-2H3,(H,26,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331502
(1-{3-[(6-Fluoro-1,1-dioxo-1H-1lambda*6*-benzo[d]is...)Show SMILES CNC(=O)NCC(C)(C)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:11| Show InChI InChI=1S/C20H23FN4O3S/c1-20(2,12-23-19(26)22-3)13-25(15-7-5-4-6-8-15)18-16-10-9-14(21)11-17(16)29(27,28)24-18/h4-11H,12-13H2,1-3H3,(H2,22,23,26) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.22E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331500
(CHEMBL1290064 | N-{3-[(6-Fluoro-1,1-dioxo-1H-1lamb...)Show SMILES Cn1cccc1CC(=O)NCC(C)(C)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:17| Show InChI InChI=1S/C25H27FN4O3S/c1-25(2,16-27-23(31)15-20-10-7-13-29(20)3)17-30(19-8-5-4-6-9-19)24-21-12-11-18(26)14-22(21)34(32,33)28-24/h4-14H,15-17H2,1-3H3,(H,27,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.56E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331501
(1-Amino-cyclopentanecarboxylic acid{3-[(6-fluoro-1...)Show SMILES CC(C)(CNC(=O)C1(N)CCCC1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:16| Show InChI InChI=1S/C24H29FN4O3S/c1-23(2,15-27-22(30)24(26)12-6-7-13-24)16-29(18-8-4-3-5-9-18)21-19-11-10-17(25)14-20(19)33(31,32)28-21/h3-5,8-11,14H,6-7,12-13,15-16,26H2,1-2H3,(H,27,30) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.64E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331503
(1-Methyl-piperidine-2-carboxylic acid{3-[(6-fluoro...)Show SMILES CN1CCCCC1C(=O)NCC(C)(C)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:17| Show InChI InChI=1S/C25H31FN4O3S/c1-25(2,16-27-24(31)21-11-7-8-14-29(21)3)17-30(19-9-5-4-6-10-19)23-20-13-12-18(26)15-22(20)34(32,33)28-23/h4-6,9-10,12-13,15,21H,7-8,11,14,16-17H2,1-3H3,(H,27,31) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.88E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331502
(1-{3-[(6-Fluoro-1,1-dioxo-1H-1lambda*6*-benzo[d]is...)Show SMILES CNC(=O)NCC(C)(C)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:11| Show InChI InChI=1S/C20H23FN4O3S/c1-20(2,12-23-19(26)22-3)13-25(15-7-5-4-6-8-15)18-16-10-9-14(21)11-17(16)29(27,28)24-18/h4-11H,12-13H2,1-3H3,(H2,22,23,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.08E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331503
(1-Methyl-piperidine-2-carboxylic acid{3-[(6-fluoro...)Show SMILES CN1CCCCC1C(=O)NCC(C)(C)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:17| Show InChI InChI=1S/C25H31FN4O3S/c1-25(2,16-27-24(31)21-11-7-8-14-29(21)3)17-30(19-9-5-4-6-10-19)23-20-13-12-18(26)15-22(20)34(32,33)28-23/h4-6,9-10,12-13,15,21H,7-8,11,14,16-17H2,1-3H3,(H,27,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50279106
(4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one | ...)Show InChI InChI=1S/C21H18O5/c22-20-9-8-16-19(26-20)14-18-17(10-13-24-18)21(16)25-12-5-4-11-23-15-6-2-1-3-7-15/h1-3,6-10,13-14H,4-5,11-12H2 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3.45E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331504
(CHEMBL1290171 | Piperidine-2-carboxylic acid{3-[(6...)Show SMILES CC(C)(CNC(=O)C1CCCCN1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:16| Show InChI InChI=1S/C24H29FN4O3S/c1-24(2,15-27-23(30)20-10-6-7-13-26-20)16-29(18-8-4-3-5-9-18)22-19-12-11-17(25)14-21(19)33(31,32)28-22/h3-5,8-9,11-12,14,20,26H,6-7,10,13,15-16H2,1-2H3,(H,27,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331504
(CHEMBL1290171 | Piperidine-2-carboxylic acid{3-[(6...)Show SMILES CC(C)(CNC(=O)C1CCCCN1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:16| Show InChI InChI=1S/C24H29FN4O3S/c1-24(2,15-27-23(30)20-10-6-7-13-26-20)16-29(18-8-4-3-5-9-18)22-19-12-11-17(25)14-21(19)33(31,32)28-22/h3-5,8-9,11-12,14,20,26H,6-7,10,13,15-16H2,1-2H3,(H,27,30) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.97E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331505
(CHEMBL1289418 | N-{3-[(6-Fluoro-1,1-dioxo-1H-1lamb...)Show SMILES CC(C)(CNC(=O)c1ccc[nH]c1=O)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:17| Show InChI InChI=1S/C24H23FN4O4S/c1-24(2,14-27-23(31)19-9-6-12-26-22(19)30)15-29(17-7-4-3-5-8-17)21-18-11-10-16(25)13-20(18)34(32,33)28-21/h3-13H,14-15H2,1-2H3,(H,26,30)(H,27,31) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.06E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331505
(CHEMBL1289418 | N-{3-[(6-Fluoro-1,1-dioxo-1H-1lamb...)Show SMILES CC(C)(CNC(=O)c1ccc[nH]c1=O)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:17| Show InChI InChI=1S/C24H23FN4O4S/c1-24(2,14-27-23(31)19-9-6-12-26-22(19)30)15-29(17-7-4-3-5-8-17)21-18-11-10-16(25)13-20(18)34(32,33)28-21/h3-13H,14-15H2,1-2H3,(H,26,30)(H,27,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.01E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331506
(1-Methyl-piperidine-3-carboxylic acid{3-[(6-fluoro...)Show SMILES CN1CCCC(C1)C(=O)NCC(C)(C)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:17| Show InChI InChI=1S/C25H31FN4O3S/c1-25(2,16-27-24(31)18-8-7-13-29(3)15-18)17-30(20-9-5-4-6-10-20)23-21-12-11-19(26)14-22(21)34(32,33)28-23/h4-6,9-12,14,18H,7-8,13,15-17H2,1-3H3,(H,27,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331507
(1-Methyl-1H-imidazole-4-carboxylic acid{3-[(6-fluo...)Show SMILES Cn1cnc(c1)C(=O)NCC(C)(C)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:16| Show InChI InChI=1S/C23H24FN5O3S/c1-23(2,13-25-22(30)19-12-28(3)15-26-19)14-29(17-7-5-4-6-8-17)21-18-10-9-16(24)11-20(18)33(31,32)27-21/h4-12,15H,13-14H2,1-3H3,(H,25,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.31E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331506
(1-Methyl-piperidine-3-carboxylic acid{3-[(6-fluoro...)Show SMILES CN1CCCC(C1)C(=O)NCC(C)(C)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:17| Show InChI InChI=1S/C25H31FN4O3S/c1-25(2,16-27-24(31)18-8-7-13-29(3)15-18)17-30(20-9-5-4-6-10-20)23-21-12-11-19(26)14-22(21)34(32,33)28-23/h4-6,9-12,14,18H,7-8,13,15-17H2,1-3H3,(H,27,31) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.37E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331507
(1-Methyl-1H-imidazole-4-carboxylic acid{3-[(6-fluo...)Show SMILES Cn1cnc(c1)C(=O)NCC(C)(C)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:16| Show InChI InChI=1S/C23H24FN5O3S/c1-23(2,13-25-22(30)19-12-28(3)15-26-19)14-29(17-7-5-4-6-8-17)21-18-10-9-16(24)11-20(18)33(31,32)27-21/h4-12,15H,13-14H2,1-3H3,(H,25,30) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.39E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331508
(1-{3-[(6-Fluoro-1,1-dioxo-1H-1lambda*6*-benzo[d]is...)Show SMILES CC(C)(CNC(=O)C1(CC1)C(O)=O)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:16| Show InChI InChI=1S/C23H24FN3O5S/c1-22(2,13-25-20(28)23(10-11-23)21(29)30)14-27(16-6-4-3-5-7-16)19-17-9-8-15(24)12-18(17)33(31,32)26-19/h3-9,12H,10-11,13-14H2,1-2H3,(H,25,28)(H,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331509
(1-Methyl-piperidine-4-carboxylic acid{3-[(6-fluoro...)Show SMILES CN1CCC(CC1)C(=O)NCC(C)(C)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:17| Show InChI InChI=1S/C25H31FN4O3S/c1-25(2,16-27-24(31)18-11-13-29(3)14-12-18)17-30(20-7-5-4-6-8-20)23-21-10-9-19(26)15-22(21)34(32,33)28-23/h4-10,15,18H,11-14,16-17H2,1-3H3,(H,27,31) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331510
(CHEMBL1290397 | Piperidine-3-carboxylic acid{3-[(6...)Show SMILES CC(C)(CNC(=O)C1CCCNC1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:16| Show InChI InChI=1S/C24H29FN4O3S/c1-24(2,15-27-23(30)17-7-6-12-26-14-17)16-29(19-8-4-3-5-9-19)22-20-11-10-18(25)13-21(20)33(31,32)28-22/h3-5,8-11,13,17,26H,6-7,12,14-16H2,1-2H3,(H,27,30) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331512
(CHEMBL1289189 | N-{3-[(6-Fluoro-1,1-dioxo-1H-1lamb...)Show SMILES CC(C)(CNC(=O)c1ccncc1O)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:17| Show InChI InChI=1S/C24H23FN4O4S/c1-24(2,14-27-23(31)18-10-11-26-13-20(18)30)15-29(17-6-4-3-5-7-17)22-19-9-8-16(25)12-21(19)34(32,33)28-22/h3-13,30H,14-15H2,1-2H3,(H,27,31) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331512
(CHEMBL1289189 | N-{3-[(6-Fluoro-1,1-dioxo-1H-1lamb...)Show SMILES CC(C)(CNC(=O)c1ccncc1O)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:17| Show InChI InChI=1S/C24H23FN4O4S/c1-24(2,14-27-23(31)18-10-11-26-13-20(18)30)15-29(17-6-4-3-5-7-17)22-19-9-8-16(25)12-21(19)34(32,33)28-22/h3-13,30H,14-15H2,1-2H3,(H,27,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331510
(CHEMBL1290397 | Piperidine-3-carboxylic acid{3-[(6...)Show SMILES CC(C)(CNC(=O)C1CCCNC1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:16| Show InChI InChI=1S/C24H29FN4O3S/c1-24(2,15-27-23(30)17-7-6-12-26-14-17)16-29(19-8-4-3-5-9-19)22-20-11-10-18(25)13-21(20)33(31,32)28-22/h3-5,8-11,13,17,26H,6-7,12,14-16H2,1-2H3,(H,27,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331508
(1-{3-[(6-Fluoro-1,1-dioxo-1H-1lambda*6*-benzo[d]is...)Show SMILES CC(C)(CNC(=O)C1(CC1)C(O)=O)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:16| Show InChI InChI=1S/C23H24FN3O5S/c1-22(2,13-25-20(28)23(10-11-23)21(29)30)14-27(16-6-4-3-5-7-16)19-17-9-8-15(24)12-18(17)33(31,32)26-19/h3-9,12H,10-11,13-14H2,1-2H3,(H,25,28)(H,29,30) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331511
(Benzofuran-2-carboxylic acid{3-[(6-fluoro-1,1-diox...)Show SMILES CC(C)(CNC(=O)c1cc2ccccc2o1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:20| Show InChI InChI=1S/C27H24FN3O4S/c1-27(2,16-29-26(32)23-14-18-8-6-7-11-22(18)35-23)17-31(20-9-4-3-5-10-20)25-21-13-12-19(28)15-24(21)36(33,34)30-25/h3-15H,16-17H2,1-2H3,(H,29,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 3
(Homo sapiens (Human)) | BDBM50331509
(1-Methyl-piperidine-4-carboxylic acid{3-[(6-fluoro...)Show SMILES CN1CCC(CC1)C(=O)NCC(C)(C)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:17| Show InChI InChI=1S/C25H31FN4O3S/c1-25(2,16-27-24(31)18-11-13-29(3)14-12-18)17-30(20-7-5-4-6-8-20)23-21-10-9-19(26)15-22(21)34(32,33)28-23/h4-10,15,18H,11-14,16-17H2,1-3H3,(H,27,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50331511
(Benzofuran-2-carboxylic acid{3-[(6-fluoro-1,1-diox...)Show SMILES CC(C)(CNC(=O)c1cc2ccccc2o1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:20| Show InChI InChI=1S/C27H24FN3O4S/c1-27(2,16-29-26(32)23-14-18-8-6-7-11-22(18)35-23)17-31(20-9-4-3-5-10-20)25-21-13-12-19(28)15-24(21)36(33,34)30-25/h3-15H,16-17H2,1-2H3,(H,29,32) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells |
Bioorg Med Chem Lett 20: 6989-92 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.131
BindingDB Entry DOI: 10.7270/Q2HD7VW2 |
More data for this
Ligand-Target Pair | |
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