Affinity Data by PubMed id=21055954

PubMed code 21055954

Found 21 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Extracellular calcium-sensing receptor (Homo sapiens (Human))	BDBM50331964 (CHEMBL1290328 \| N-(1-Adamantyl)-7,7-dimethyl-5-phe...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Antagonist activity at CaSR expressed in CHO cells assessed as [35S]-GTPgammaS binding by scintillation counting				Bioorg Med Chem 18: 8501-11 (2010) Article DOI: 10.1016/j.bmc.2010.10.035 BindingDB Entry DOI: 10.7270/Q2CJ8DRD
Takeda Pharmaceutical Company Limited Curated by ChEMBL					More data for this Ligand-Target Pair
Extracellular calcium-sensing receptor (Homo sapiens (Human))	BDBM50331946 (CHEMBL1289345 \| N-(1-Adamantyl)-5-phenyl-7-(triflu...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Antagonist activity at CaSR expressed in CHO cells assessed as [35S]-GTPgammaS binding by scintillation counting				Bioorg Med Chem 18: 8501-11 (2010) Article DOI: 10.1016/j.bmc.2010.10.035 BindingDB Entry DOI: 10.7270/Q2CJ8DRD
Takeda Pharmaceutical Company Limited Curated by ChEMBL					More data for this Ligand-Target Pair
Extracellular calcium-sensing receptor (Homo sapiens (Human))	BDBM50331960 (CHEMBL1290106 \| N-(1-Adamantyl)-7-methyl-5-phenyl-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	76	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Antagonist activity at CaSR expressed in CHO cells assessed as [35S]-GTPgammaS binding by scintillation counting				Bioorg Med Chem 18: 8501-11 (2010) Article DOI: 10.1016/j.bmc.2010.10.035 BindingDB Entry DOI: 10.7270/Q2CJ8DRD
Takeda Pharmaceutical Company Limited Curated by ChEMBL					More data for this Ligand-Target Pair
Extracellular calcium-sensing receptor (Homo sapiens (Human))	BDBM50331947 (1-Adamantyl-5-phenyl-7-(trifluoromethyl)-4,5,6,7-t...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	97	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Antagonist activity at CaSR expressed in CHO cells assessed as [35S]-GTPgammaS binding by scintillation counting				Bioorg Med Chem 18: 8501-11 (2010) Article DOI: 10.1016/j.bmc.2010.10.035 BindingDB Entry DOI: 10.7270/Q2CJ8DRD
Takeda Pharmaceutical Company Limited Curated by ChEMBL					More data for this Ligand-Target Pair
Extracellular calcium-sensing receptor (Homo sapiens (Human))	BDBM50331951 (CHEMBL1289573 \| N-(1-Adamantyl)-5-(2-chlorophenyl)...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Antagonist activity at CaSR expressed in CHO cells assessed as [35S]-GTPgammaS binding by scintillation counting				Bioorg Med Chem 18: 8501-11 (2010) Article DOI: 10.1016/j.bmc.2010.10.035 BindingDB Entry DOI: 10.7270/Q2CJ8DRD
Takeda Pharmaceutical Company Limited Curated by ChEMBL					More data for this Ligand-Target Pair
Extracellular calcium-sensing receptor (Homo sapiens (Human))	BDBM50331952 (CHEMBL1289679 \| N-(1-Adamantyl)-5-(3-chlorophenyl)...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Antagonist activity at CaSR expressed in CHO cells assessed as [35S]-GTPgammaS binding by scintillation counting				Bioorg Med Chem 18: 8501-11 (2010) Article DOI: 10.1016/j.bmc.2010.10.035 BindingDB Entry DOI: 10.7270/Q2CJ8DRD
Takeda Pharmaceutical Company Limited Curated by ChEMBL					More data for this Ligand-Target Pair
Extracellular calcium-sensing receptor (Homo sapiens (Human))	BDBM50331956 (CHEMBL1289892 \| N-(1-Adamantyl)-5-(2-furanyl)-7-(t...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Antagonist activity at CaSR expressed in CHO cells assessed as [35S]-GTPgammaS binding by scintillation counting				Bioorg Med Chem 18: 8501-11 (2010) Article DOI: 10.1016/j.bmc.2010.10.035 BindingDB Entry DOI: 10.7270/Q2CJ8DRD
Takeda Pharmaceutical Company Limited Curated by ChEMBL					More data for this Ligand-Target Pair
Extracellular calcium-sensing receptor (Homo sapiens (Human))	BDBM50331965 (CHEMBL1290329 \| N-(1-Adamantyl)-7,7-dimethyl-5-phe...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	580	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Antagonist activity at CaSR expressed in CHO cells assessed as [35S]-GTPgammaS binding by scintillation counting				Bioorg Med Chem 18: 8501-11 (2010) Article DOI: 10.1016/j.bmc.2010.10.035 BindingDB Entry DOI: 10.7270/Q2CJ8DRD
Takeda Pharmaceutical Company Limited Curated by ChEMBL					More data for this Ligand-Target Pair
Extracellular calcium-sensing receptor (Homo sapiens (Human))	BDBM50331959 (CHEMBL1290007 \| N-(1-Adamantyl)-5,7-diphenyl-4,5,6...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Antagonist activity at CaSR expressed in CHO cells assessed as [35S]-GTPgammaS binding by scintillation counting				Bioorg Med Chem 18: 8501-11 (2010) Article DOI: 10.1016/j.bmc.2010.10.035 BindingDB Entry DOI: 10.7270/Q2CJ8DRD
Takeda Pharmaceutical Company Limited Curated by ChEMBL					More data for this Ligand-Target Pair
Extracellular calcium-sensing receptor (Homo sapiens (Human))	BDBM50331963 (CHEMBL1290216 \| N-(1-Adamantyl)-5-phenyl-4,5,6,7-t...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Antagonist activity at CaSR expressed in CHO cells assessed as [35S]-GTPgammaS binding by scintillation counting				Bioorg Med Chem 18: 8501-11 (2010) Article DOI: 10.1016/j.bmc.2010.10.035 BindingDB Entry DOI: 10.7270/Q2CJ8DRD
Takeda Pharmaceutical Company Limited Curated by ChEMBL					More data for this Ligand-Target Pair
Extracellular calcium-sensing receptor (Homo sapiens (Human))	BDBM50331958 (CHEMBL1290006 \| N-(1-Adamantyl)-5-tert-butyl-7-(tr...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Antagonist activity at CaSR expressed in CHO cells assessed as [35S]-GTPgammaS binding by scintillation counting				Bioorg Med Chem 18: 8501-11 (2010) Article DOI: 10.1016/j.bmc.2010.10.035 BindingDB Entry DOI: 10.7270/Q2CJ8DRD
Takeda Pharmaceutical Company Limited Curated by ChEMBL					More data for this Ligand-Target Pair
Extracellular calcium-sensing receptor (Homo sapiens (Human))	BDBM50331949 (CHEMBL1289464 \| N-[5-Phenyl-7-(trifluoromethyl)-4,...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Antagonist activity at CaSR expressed in CHO cells assessed as [35S]-GTPgammaS binding by scintillation counting				Bioorg Med Chem 18: 8501-11 (2010) Article DOI: 10.1016/j.bmc.2010.10.035 BindingDB Entry DOI: 10.7270/Q2CJ8DRD
Takeda Pharmaceutical Company Limited Curated by ChEMBL					More data for this Ligand-Target Pair
Extracellular calcium-sensing receptor (Homo sapiens (Human))	BDBM50331955 (CHEMBL1289783 \| N-(1-Adamantyl)-5-(4-ethyphenyl)-7...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Antagonist activity at CaSR expressed in CHO cells assessed as [35S]-GTPgammaS binding by scintillation counting				Bioorg Med Chem 18: 8501-11 (2010) Article DOI: 10.1016/j.bmc.2010.10.035 BindingDB Entry DOI: 10.7270/Q2CJ8DRD
Takeda Pharmaceutical Company Limited Curated by ChEMBL					More data for this Ligand-Target Pair
Extracellular calcium-sensing receptor (Homo sapiens (Human))	BDBM50331950 (CHEMBL1289572 \| N-{[5-Phenyl-7-(trifluoromethyl)-4...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Antagonist activity at CaSR expressed in CHO cells assessed as [35S]-GTPgammaS binding by scintillation counting				Bioorg Med Chem 18: 8501-11 (2010) Article DOI: 10.1016/j.bmc.2010.10.035 BindingDB Entry DOI: 10.7270/Q2CJ8DRD
Takeda Pharmaceutical Company Limited Curated by ChEMBL					More data for this Ligand-Target Pair
Extracellular calcium-sensing receptor (Homo sapiens (Human))	BDBM50331957 (CHEMBL1289893 \| N-(1-Adamantyl)-5-pyridin-3-yl-7-(...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Antagonist activity at CaSR expressed in CHO cells assessed as [35S]-GTPgammaS binding by scintillation counting				Bioorg Med Chem 18: 8501-11 (2010) Article DOI: 10.1016/j.bmc.2010.10.035 BindingDB Entry DOI: 10.7270/Q2CJ8DRD
Takeda Pharmaceutical Company Limited Curated by ChEMBL					More data for this Ligand-Target Pair
Extracellular calcium-sensing receptor (Homo sapiens (Human))	BDBM50331962 (CHEMBL1290215 \| N-(1-Adamantyl)-7-trifluoromethyl-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Antagonist activity at CaSR expressed in CHO cells assessed as [35S]-GTPgammaS binding by scintillation counting				Bioorg Med Chem 18: 8501-11 (2010) Article DOI: 10.1016/j.bmc.2010.10.035 BindingDB Entry DOI: 10.7270/Q2CJ8DRD
Takeda Pharmaceutical Company Limited Curated by ChEMBL					More data for this Ligand-Target Pair
Extracellular calcium-sensing receptor (Homo sapiens (Human))	BDBM50331953 (CHEMBL1289680 \| N-(1-Adamantyl)-5-(4-chlorophenyl)...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Antagonist activity at CaSR expressed in CHO cells assessed as [35S]-GTPgammaS binding by scintillation counting				Bioorg Med Chem 18: 8501-11 (2010) Article DOI: 10.1016/j.bmc.2010.10.035 BindingDB Entry DOI: 10.7270/Q2CJ8DRD
Takeda Pharmaceutical Company Limited Curated by ChEMBL					More data for this Ligand-Target Pair
Extracellular calcium-sensing receptor (Homo sapiens (Human))	BDBM50331961 (CHEMBL1290107 \| N-(1-Adamantyl)-5-methyl-7-phenyl-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Antagonist activity at CaSR expressed in CHO cells assessed as [35S]-GTPgammaS binding by scintillation counting				Bioorg Med Chem 18: 8501-11 (2010) Article DOI: 10.1016/j.bmc.2010.10.035 BindingDB Entry DOI: 10.7270/Q2CJ8DRD
Takeda Pharmaceutical Company Limited Curated by ChEMBL					More data for this Ligand-Target Pair
Extracellular calcium-sensing receptor (Homo sapiens (Human))	BDBM50331966 (CHEMBL1290440 \| N-(1-Adamantyl)-5-phenyl-7-(triflu...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Antagonist activity at CaSR expressed in CHO cells assessed as [35S]-GTPgammaS binding by scintillation counting				Bioorg Med Chem 18: 8501-11 (2010) Article DOI: 10.1016/j.bmc.2010.10.035 BindingDB Entry DOI: 10.7270/Q2CJ8DRD
Takeda Pharmaceutical Company Limited Curated by ChEMBL					More data for this Ligand-Target Pair
Extracellular calcium-sensing receptor (Homo sapiens (Human))	BDBM50331948 (CHEMBL1289463 \| N-(1-Adamantyl)-4-methyl-7-trifluo...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Antagonist activity at CaSR expressed in CHO cells assessed as [35S]-GTPgammaS binding by scintillation counting				Bioorg Med Chem 18: 8501-11 (2010) Article DOI: 10.1016/j.bmc.2010.10.035 BindingDB Entry DOI: 10.7270/Q2CJ8DRD
Takeda Pharmaceutical Company Limited Curated by ChEMBL					More data for this Ligand-Target Pair
Extracellular calcium-sensing receptor (Homo sapiens (Human))	BDBM50331954 (CHEMBL1289782 \| N-(1-Adamantyl)-5-(4-methoxyphenyl...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Antagonist activity at CaSR expressed in CHO cells assessed as [35S]-GTPgammaS binding by scintillation counting				Bioorg Med Chem 18: 8501-11 (2010) Article DOI: 10.1016/j.bmc.2010.10.035 BindingDB Entry DOI: 10.7270/Q2CJ8DRD
Takeda Pharmaceutical Company Limited Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%