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PubMed code 21071223

Compile data set for download or QSAR
Found 190 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332091
PNG
(CHEMBL1288160 | N-(4,4'-bithiazol-5-yl)-2-(isoquin...)
Show SMILES O=C(Cc1cccc2cnccc12)Nc1scnc1-c1cscn1
Show InChI InChI=1S/C17H12N4OS2/c22-15(6-11-2-1-3-12-7-18-5-4-13(11)12)21-17-16(20-10-24-17)14-8-23-9-19-14/h1-5,7-10H,6H2,(H,21,22)
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n/an/a 48n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332091
PNG
(CHEMBL1288160 | N-(4,4'-bithiazol-5-yl)-2-(isoquin...)
Show SMILES O=C(Cc1cccc2cnccc12)Nc1scnc1-c1cscn1
Show InChI InChI=1S/C17H12N4OS2/c22-15(6-11-2-1-3-12-7-18-5-4-13(11)12)21-17-16(20-10-24-17)14-8-23-9-19-14/h1-5,7-10H,6H2,(H,21,22)
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n/an/a 77n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332086
PNG
(2-(isoquinolin-5-yl)-N-(2-(thiazol-4-yl)thiophen-3...)
Show SMILES O=C(Cc1cccc2cnccc12)Nc1ccsc1-c1cscn1
Show InChI InChI=1S/C18H13N3OS2/c22-17(8-12-2-1-3-13-9-19-6-4-14(12)13)21-15-5-7-24-18(15)16-10-23-11-20-16/h1-7,9-11H,8H2,(H,21,22)
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n/an/a 140n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332086
PNG
(2-(isoquinolin-5-yl)-N-(2-(thiazol-4-yl)thiophen-3...)
Show SMILES O=C(Cc1cccc2cnccc12)Nc1ccsc1-c1cscn1
Show InChI InChI=1S/C18H13N3OS2/c22-17(8-12-2-1-3-13-9-19-6-4-14(12)13)21-15-5-7-24-18(15)16-10-23-11-20-16/h1-7,9-11H,8H2,(H,21,22)
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n/an/a 160n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332082
PNG
(2-(4-methoxyphenyl)-N-(2-(oxazol-2-yl)thiophen-3-y...)
Show SMILES COc1ccc(CC(=O)Nc2ccsc2-c2ncco2)cc1
Show InChI InChI=1S/C16H14N2O3S/c1-20-12-4-2-11(3-5-12)10-14(19)18-13-6-9-22-15(13)16-17-7-8-21-16/h2-9H,10H2,1H3,(H,18,19)
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n/an/a 220n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332073
PNG
(CHEMBL1287974 | N-(2-(5-methyl-1H-1,2,4-triazol-3-...)
Show SMILES Cc1nnc([nH]1)-c1sccc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C19H16N4OS/c1-12-20-19(23-22-12)18-16(9-10-25-18)21-17(24)11-14-7-4-6-13-5-2-3-8-15(13)14/h2-10H,11H2,1H3,(H,21,24)(H,20,22,23)
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n/an/a 250n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332085
PNG
(CHEMBL1288099 | N-(2-(4H-1,2,4-triazol-3-yl)thioph...)
Show SMILES O=C(Cc1cccc2ncccc12)Nc1ccsc1-c1nnc[nH]1
Show InChI InChI=1S/C17H13N5OS/c23-15(9-11-3-1-5-13-12(11)4-2-7-18-13)21-14-6-8-24-16(14)17-19-10-20-22-17/h1-8,10H,9H2,(H,21,23)(H,19,20,22)
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n/an/a 270n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332050
PNG
(CHEMBL1288215 | methyl 3-(2-(isoquinolin-5-yl)acet...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1cccc2cnccc12
Show InChI InChI=1S/C17H14N2O3S/c1-22-17(21)16-14(6-8-23-16)19-15(20)9-11-3-2-4-12-10-18-7-5-13(11)12/h2-8,10H,9H2,1H3,(H,19,20)
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n/an/a 270n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332086
PNG
(2-(isoquinolin-5-yl)-N-(2-(thiazol-4-yl)thiophen-3...)
Show SMILES O=C(Cc1cccc2cnccc12)Nc1ccsc1-c1cscn1
Show InChI InChI=1S/C18H13N3OS2/c22-17(8-12-2-1-3-13-9-19-6-4-14(12)13)21-15-5-7-24-18(15)16-10-23-11-20-16/h1-7,9-11H,8H2,(H,21,22)
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n/an/a 270n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332051
PNG
(CHEMBL1288216 | methyl 3-(2-(quinolin-5-yl)acetami...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1cccc2ncccc12
Show InChI InChI=1S/C17H14N2O3S/c1-22-17(21)16-14(7-9-23-16)19-15(20)10-11-4-2-6-13-12(11)5-3-8-18-13/h2-9H,10H2,1H3,(H,19,20)
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n/an/a 300n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332053
PNG
(CHEMBL1288966 | ethyl 3-(2-phenylacetamido)thiophe...)
Show SMILES CCOC(=O)c1sccc1NC(=O)Cc1ccccc1
Show InChI InChI=1S/C15H15NO3S/c1-2-19-15(18)14-12(8-9-20-14)16-13(17)10-11-6-4-3-5-7-11/h3-9H,2,10H2,1H3,(H,16,17)
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n/an/a 300n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332048
PNG
(CHEMBL1288188 | methyl 3-(2-(naphthalen-1-yl)aceta...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C18H15NO3S/c1-22-18(21)17-15(9-10-23-17)19-16(20)11-13-7-4-6-12-5-2-3-8-14(12)13/h2-10H,11H2,1H3,(H,19,20)
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n/an/a 400n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332090
PNG
(2-(isoquinolin-5-yl)-N-(4-(pyrazin-2-yl)thiazol-5-...)
Show SMILES O=C(Cc1cccc2cnccc12)Nc1scnc1-c1cnccn1
Show InChI InChI=1S/C18H13N5OS/c24-16(8-12-2-1-3-13-9-19-5-4-14(12)13)23-18-17(22-11-25-18)15-10-20-6-7-21-15/h1-7,9-11H,8H2,(H,23,24)
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n/an/a 410n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332044
PNG
(CHEMBL1288157 | methyl 3-(2-(4-(pyridin-4-yl)pheny...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1ccc(cc1)-c1ccncc1
Show InChI InChI=1S/C19H16N2O3S/c1-24-19(23)18-16(8-11-25-18)21-17(22)12-13-2-4-14(5-3-13)15-6-9-20-10-7-15/h2-11H,12H2,1H3,(H,21,22)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332090
PNG
(2-(isoquinolin-5-yl)-N-(4-(pyrazin-2-yl)thiazol-5-...)
Show SMILES O=C(Cc1cccc2cnccc12)Nc1scnc1-c1cnccn1
Show InChI InChI=1S/C18H13N5OS/c24-16(8-12-2-1-3-13-9-19-5-4-14(12)13)23-18-17(22-11-25-18)15-10-20-6-7-21-15/h1-7,9-11H,8H2,(H,23,24)
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n/an/a 470n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332091
PNG
(CHEMBL1288160 | N-(4,4'-bithiazol-5-yl)-2-(isoquin...)
Show SMILES O=C(Cc1cccc2cnccc12)Nc1scnc1-c1cscn1
Show InChI InChI=1S/C17H12N4OS2/c22-15(6-11-2-1-3-12-7-18-5-4-13(11)12)21-17-16(20-10-24-17)14-8-23-9-19-14/h1-5,7-10H,6H2,(H,21,22)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332054
PNG
(CHEMBL1288243 | isopropyl 3-(2-phenylacetamido)thi...)
Show SMILES CC(C)OC(=O)c1sccc1NC(=O)Cc1ccccc1
Show InChI InChI=1S/C16H17NO3S/c1-11(2)20-16(19)15-13(8-9-21-15)17-14(18)10-12-6-4-3-5-7-12/h3-9,11H,10H2,1-2H3,(H,17,18)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332070
PNG
(CHEMBL1287916 | N-(2-(1H-1,2,4-triazol-3-yl)thioph...)
Show SMILES O=C(Cc1cccc2ccccc12)Nc1ccsc1-c1nnc[nH]1
Show InChI InChI=1S/C18H14N4OS/c23-16(10-13-6-3-5-12-4-1-2-7-14(12)13)21-15-8-9-24-17(15)18-19-11-20-22-18/h1-9,11H,10H2,(H,21,23)(H,19,20,22)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332073
PNG
(CHEMBL1287974 | N-(2-(5-methyl-1H-1,2,4-triazol-3-...)
Show SMILES Cc1nnc([nH]1)-c1sccc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C19H16N4OS/c1-12-20-19(23-22-12)18-16(9-10-25-18)21-17(24)11-14-7-4-6-13-5-2-3-8-15(13)14/h2-10H,11H2,1H3,(H,21,24)(H,20,22,23)
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n/an/a 550n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332085
PNG
(CHEMBL1288099 | N-(2-(4H-1,2,4-triazol-3-yl)thioph...)
Show SMILES O=C(Cc1cccc2ncccc12)Nc1ccsc1-c1nnc[nH]1
Show InChI InChI=1S/C17H13N5OS/c23-15(9-11-3-1-5-13-12(11)4-2-7-18-13)21-14-6-8-24-16(14)17-19-10-20-22-17/h1-8,10H,9H2,(H,21,23)(H,19,20,22)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332047
PNG
(CHEMBL1288187 | methyl 3-(2-(naphthalen-2-yl)aceta...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1ccc2ccccc2c1
Show InChI InChI=1S/C18H15NO3S/c1-22-18(21)17-15(8-9-23-17)19-16(20)11-12-6-7-13-4-2-3-5-14(13)10-12/h2-10H,11H2,1H3,(H,19,20)
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n/an/a 600n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332050
PNG
(CHEMBL1288215 | methyl 3-(2-(isoquinolin-5-yl)acet...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1cccc2cnccc12
Show InChI InChI=1S/C17H14N2O3S/c1-22-17(21)16-14(6-8-23-16)19-15(20)9-11-3-2-4-12-10-18-7-5-13(11)12/h2-8,10H,9H2,1H3,(H,19,20)
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n/an/a 610n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332051
PNG
(CHEMBL1288216 | methyl 3-(2-(quinolin-5-yl)acetami...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1cccc2ncccc12
Show InChI InChI=1S/C17H14N2O3S/c1-22-17(21)16-14(7-9-23-16)19-15(20)10-11-4-2-6-13-12(11)5-3-8-18-13/h2-9H,10H2,1H3,(H,19,20)
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n/an/a 610n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332044
PNG
(CHEMBL1288157 | methyl 3-(2-(4-(pyridin-4-yl)pheny...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1ccc(cc1)-c1ccncc1
Show InChI InChI=1S/C19H16N2O3S/c1-24-19(23)18-16(8-11-25-18)21-17(22)12-13-2-4-14(5-3-13)15-6-9-20-10-7-15/h2-11H,12H2,1H3,(H,21,22)
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n/an/a 690n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332053
PNG
(CHEMBL1288966 | ethyl 3-(2-phenylacetamido)thiophe...)
Show SMILES CCOC(=O)c1sccc1NC(=O)Cc1ccccc1
Show InChI InChI=1S/C15H15NO3S/c1-2-19-15(18)14-12(8-9-20-14)16-13(17)10-11-6-4-3-5-7-11/h3-9H,2,10H2,1H3,(H,16,17)
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n/an/a 700n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332041
PNG
(CHEMBL1288930 | methyl 3-(2-phenylacetamido)thioph...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1ccccc1
Show InChI InChI=1S/C14H13NO3S/c1-18-14(17)13-11(7-8-19-13)15-12(16)9-10-5-3-2-4-6-10/h2-8H,9H2,1H3,(H,15,16)
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n/an/a 700n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332085
PNG
(CHEMBL1288099 | N-(2-(4H-1,2,4-triazol-3-yl)thioph...)
Show SMILES O=C(Cc1cccc2ncccc12)Nc1ccsc1-c1nnc[nH]1
Show InChI InChI=1S/C17H13N5OS/c23-15(9-11-3-1-5-13-12(11)4-2-7-18-13)21-14-6-8-24-16(14)17-19-10-20-22-17/h1-8,10H,9H2,(H,21,23)(H,19,20,22)
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n/an/a 710n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332088
PNG
(CHEMBL1288128 | N-(4-(1H-1,2,4-triazol-3-yl)thiazo...)
Show SMILES O=C(Cc1cccc2cnccc12)Nc1scnc1-c1nnc[nH]1
Show InChI InChI=1S/C16H12N6OS/c23-13(6-10-2-1-3-11-7-17-5-4-12(10)11)21-16-14(19-9-24-16)15-18-8-20-22-15/h1-5,7-9H,6H2,(H,21,23)(H,18,20,22)
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n/an/a 710n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332080
PNG
(CHEMBL1288039 | N-(2-(5-amino-1H-1,2,4-triazol-3-y...)
Show SMILES COc1ccc(CC(=O)Nc2ccsc2-c2nnc(N)[nH]2)cc1
Show InChI InChI=1S/C15H15N5O2S/c1-22-10-4-2-9(3-5-10)8-12(21)17-11-6-7-23-13(11)14-18-15(16)20-19-14/h2-7H,8H2,1H3,(H,17,21)(H3,16,18,19,20)
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n/an/a 790n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332043
PNG
(CHEMBL1288156 | methyl 3-(2-(4-methoxyphenyl)aceta...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1ccc(OC)cc1
Show InChI InChI=1S/C15H15NO4S/c1-19-11-5-3-10(4-6-11)9-13(17)16-12-7-8-21-14(12)15(18)20-2/h3-8H,9H2,1-2H3,(H,16,17)
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n/an/a 800n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332082
PNG
(2-(4-methoxyphenyl)-N-(2-(oxazol-2-yl)thiophen-3-y...)
Show SMILES COc1ccc(CC(=O)Nc2ccsc2-c2ncco2)cc1
Show InChI InChI=1S/C16H14N2O3S/c1-20-12-4-2-11(3-5-12)10-14(19)18-13-6-9-22-15(13)16-17-7-8-21-16/h2-9H,10H2,1H3,(H,18,19)
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n/an/a 800n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332088
PNG
(CHEMBL1288128 | N-(4-(1H-1,2,4-triazol-3-yl)thiazo...)
Show SMILES O=C(Cc1cccc2cnccc12)Nc1scnc1-c1nnc[nH]1
Show InChI InChI=1S/C16H12N6OS/c23-13(6-10-2-1-3-11-7-17-5-4-12(10)11)21-16-14(19-9-24-16)15-18-8-20-22-15/h1-5,7-9H,6H2,(H,21,23)(H,18,20,22)
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n/an/a 820n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332077
PNG
(CHEMBL1288006 | N-(2-(2H-1,2,3-triazol-2-yl)thioph...)
Show SMILES COc1ccc(CC(=O)Nc2ccsc2-n2nccn2)cc1
Show InChI InChI=1S/C15H14N4O2S/c1-21-12-4-2-11(3-5-12)10-14(20)18-13-6-9-22-15(13)19-16-7-8-17-19/h2-9H,10H2,1H3,(H,18,20)
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n/an/a 830n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332064
PNG
(CHEMBL1287859 | methyl 4-(2-(naphthalen-1-yl)aceta...)
Show SMILES COC(=O)c1cscc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C18H15NO3S/c1-22-18(21)15-10-23-11-16(15)19-17(20)9-13-7-4-6-12-5-2-3-8-14(12)13/h2-8,10-11H,9H2,1H3,(H,19,20)
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n/an/a 890n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332064
PNG
(CHEMBL1287859 | methyl 4-(2-(naphthalen-1-yl)aceta...)
Show SMILES COC(=O)c1cscc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C18H15NO3S/c1-22-18(21)15-10-23-11-16(15)19-17(20)9-13-7-4-6-12-5-2-3-8-14(12)13/h2-8,10-11H,9H2,1H3,(H,19,20)
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n/an/a 900n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332070
PNG
(CHEMBL1287916 | N-(2-(1H-1,2,4-triazol-3-yl)thioph...)
Show SMILES O=C(Cc1cccc2ccccc12)Nc1ccsc1-c1nnc[nH]1
Show InChI InChI=1S/C18H14N4OS/c23-16(10-13-6-3-5-12-4-1-2-7-14(12)13)21-15-8-9-24-17(15)18-19-11-20-22-18/h1-9,11H,10H2,(H,21,23)(H,19,20,22)
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n/an/a 920n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332045
PNG
(CHEMBL1288158 | methyl 3-(2-(4-(1H-imidazol-1-yl)p...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1ccc(cc1)-n1ccnc1
Show InChI InChI=1S/C17H15N3O3S/c1-23-17(22)16-14(6-9-24-16)19-15(21)10-12-2-4-13(5-3-12)20-8-7-18-11-20/h2-9,11H,10H2,1H3,(H,19,21)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332043
PNG
(CHEMBL1288156 | methyl 3-(2-(4-methoxyphenyl)aceta...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1ccc(OC)cc1
Show InChI InChI=1S/C15H15NO4S/c1-19-11-5-3-10(4-6-11)9-13(17)16-12-7-8-21-14(12)15(18)20-2/h3-8H,9H2,1-2H3,(H,16,17)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332084
PNG
(2-(4-methoxyphenyl)-N-(2-(pyrazin-2-yl)thiophen-3-...)
Show SMILES COc1ccc(CC(=O)Nc2ccsc2-c2cnccn2)cc1
Show InChI InChI=1S/C17H15N3O2S/c1-22-13-4-2-12(3-5-13)10-16(21)20-14-6-9-23-17(14)15-11-18-7-8-19-15/h2-9,11H,10H2,1H3,(H,20,21)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332089
PNG
(2-(isoquinolin-5-yl)-N-(4-(1-methyl-1H-1,2,4-triaz...)
Show SMILES Cn1ncnc1-c1ncsc1NC(=O)Cc1cccc2cnccc12
Show InChI InChI=1S/C17H14N6OS/c1-23-16(19-9-21-23)15-17(25-10-20-15)22-14(24)7-11-3-2-4-12-8-18-6-5-13(11)12/h2-6,8-10H,7H2,1H3,(H,22,24)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332054
PNG
(CHEMBL1288243 | isopropyl 3-(2-phenylacetamido)thi...)
Show SMILES CC(C)OC(=O)c1sccc1NC(=O)Cc1ccccc1
Show InChI InChI=1S/C16H17NO3S/c1-11(2)20-16(19)15-13(8-9-21-15)17-14(18)10-12-6-4-3-5-7-12/h3-9,11H,10H2,1-2H3,(H,17,18)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332048
PNG
(CHEMBL1288188 | methyl 3-(2-(naphthalen-1-yl)aceta...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C18H15NO3S/c1-22-18(21)17-15(9-10-23-17)19-16(20)11-13-7-4-6-12-5-2-3-8-14(12)13/h2-10H,11H2,1H3,(H,19,20)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332077
PNG
(CHEMBL1288006 | N-(2-(2H-1,2,3-triazol-2-yl)thioph...)
Show SMILES COc1ccc(CC(=O)Nc2ccsc2-n2nccn2)cc1
Show InChI InChI=1S/C15H14N4O2S/c1-21-12-4-2-11(3-5-12)10-14(20)18-13-6-9-22-15(13)19-16-7-8-17-19/h2-9H,10H2,1H3,(H,18,20)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332075
PNG
(CHEMBL1288004 | N-(2-(5-methyl-1H-pyrazol-3-yl)thi...)
Show SMILES Cc1cc(n[nH]1)-c1sccc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C20H17N3OS/c1-13-11-18(23-22-13)20-17(9-10-25-20)21-19(24)12-15-7-4-6-14-5-2-3-8-16(14)15/h2-11H,12H2,1H3,(H,21,24)(H,22,23)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332084
PNG
(2-(4-methoxyphenyl)-N-(2-(pyrazin-2-yl)thiophen-3-...)
Show SMILES COc1ccc(CC(=O)Nc2ccsc2-c2cnccn2)cc1
Show InChI InChI=1S/C17H15N3O2S/c1-22-13-4-2-12(3-5-13)10-16(21)20-14-6-9-23-17(14)15-11-18-7-8-19-15/h2-9,11H,10H2,1H3,(H,20,21)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332045
PNG
(CHEMBL1288158 | methyl 3-(2-(4-(1H-imidazol-1-yl)p...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1ccc(cc1)-n1ccnc1
Show InChI InChI=1S/C17H15N3O3S/c1-23-17(22)16-14(6-9-24-16)19-15(21)10-12-2-4-13(5-3-12)20-8-7-18-11-20/h2-9,11H,10H2,1H3,(H,19,21)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332089
PNG
(2-(isoquinolin-5-yl)-N-(4-(1-methyl-1H-1,2,4-triaz...)
Show SMILES Cn1ncnc1-c1ncsc1NC(=O)Cc1cccc2cnccc12
Show InChI InChI=1S/C17H14N6OS/c1-23-16(19-9-21-23)15-17(25-10-20-15)22-14(24)7-11-3-2-4-12-8-18-6-5-13(11)12/h2-6,8-10H,7H2,1H3,(H,22,24)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332087
PNG
(CHEMBL1288127 | methyl 5-(2-(isoquinolin-5-yl)acet...)
Show SMILES COC(=O)c1ncsc1NC(=O)Cc1cccc2cnccc12
Show InChI InChI=1S/C16H13N3O3S/c1-22-16(21)14-15(23-9-18-14)19-13(20)7-10-3-2-4-11-8-17-6-5-12(10)11/h2-6,8-9H,7H2,1H3,(H,19,20)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332080
PNG
(CHEMBL1288039 | N-(2-(5-amino-1H-1,2,4-triazol-3-y...)
Show SMILES COc1ccc(CC(=O)Nc2ccsc2-c2nnc(N)[nH]2)cc1
Show InChI InChI=1S/C15H15N5O2S/c1-22-10-4-2-9(3-5-10)8-12(21)17-11-6-7-23-13(11)14-18-15(16)20-19-14/h2-7H,8H2,1H3,(H,17,21)(H3,16,18,19,20)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332063
PNG
(CHEMBL1287858 | methyl 2-(2-(naphthalen-1-yl)aceta...)
Show SMILES COC(=O)c1ccccc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C20H17NO3/c1-24-20(23)17-11-4-5-12-18(17)21-19(22)13-15-9-6-8-14-7-2-3-10-16(14)15/h2-12H,13H2,1H3,(H,21,22)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332087
PNG
(CHEMBL1288127 | methyl 5-(2-(isoquinolin-5-yl)acet...)
Show SMILES COC(=O)c1ncsc1NC(=O)Cc1cccc2cnccc12
Show InChI InChI=1S/C16H13N3O3S/c1-22-16(21)14-15(23-9-18-14)19-13(20)7-10-3-2-4-11-8-17-6-5-12(10)11/h2-6,8-9H,7H2,1H3,(H,19,20)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332071
PNG
(CHEMBL1287944 | N-(2-(5-methyl-1,3,4-oxadiazol-2-y...)
Show SMILES Cc1nnc(o1)-c1sccc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C19H15N3O2S/c1-12-21-22-19(24-12)18-16(9-10-25-18)20-17(23)11-14-7-4-6-13-5-2-3-8-15(13)14/h2-10H,11H2,1H3,(H,20,23)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332040
PNG
(CHEMBL1288895 | methyl 3-(2-(thiophen-2-yl)acetami...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1cccs1
Show InChI InChI=1S/C12H11NO3S2/c1-16-12(15)11-9(4-6-18-11)13-10(14)7-8-3-2-5-17-8/h2-6H,7H2,1H3,(H,13,14)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332046
PNG
(CHEMBL1288186 | methyl 3-(2-(4-(trifluoromethyl)ph...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C15H12F3NO3S/c1-22-14(21)13-11(6-7-23-13)19-12(20)8-9-2-4-10(5-3-9)15(16,17)18/h2-7H,8H2,1H3,(H,19,20)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332090
PNG
(2-(isoquinolin-5-yl)-N-(4-(pyrazin-2-yl)thiazol-5-...)
Show SMILES O=C(Cc1cccc2cnccc12)Nc1scnc1-c1cnccn1
Show InChI InChI=1S/C18H13N5OS/c24-16(8-12-2-1-3-13-9-19-5-4-14(12)13)23-18-17(22-11-25-18)15-10-20-6-7-21-15/h1-7,9-11H,8H2,(H,23,24)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332071
PNG
(CHEMBL1287944 | N-(2-(5-methyl-1,3,4-oxadiazol-2-y...)
Show SMILES Cc1nnc(o1)-c1sccc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C19H15N3O2S/c1-12-21-22-19(24-12)18-16(9-10-25-18)20-17(23)11-14-7-4-6-13-5-2-3-8-15(13)14/h2-10H,11H2,1H3,(H,20,23)
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n/an/a 2.10E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332063
PNG
(CHEMBL1287858 | methyl 2-(2-(naphthalen-1-yl)aceta...)
Show SMILES COC(=O)c1ccccc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C20H17NO3/c1-24-20(23)17-11-4-5-12-18(17)21-19(22)13-15-9-6-8-14-7-2-3-10-16(14)15/h2-12H,13H2,1H3,(H,21,22)
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n/an/a 2.10E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332065
PNG
(CHEMBL1287886 | methyl 4-(2-(naphthalen-1-yl)aceta...)
Show SMILES COC(=O)c1[nH]ncc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C17H15N3O3/c1-23-17(22)16-14(10-18-20-16)19-15(21)9-12-7-4-6-11-5-2-3-8-13(11)12/h2-8,10H,9H2,1H3,(H,18,20)(H,19,21)
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n/an/a 2.10E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332040
PNG
(CHEMBL1288895 | methyl 3-(2-(thiophen-2-yl)acetami...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1cccs1
Show InChI InChI=1S/C12H11NO3S2/c1-16-12(15)11-9(4-6-18-11)13-10(14)7-8-3-2-5-17-8/h2-6H,7H2,1H3,(H,13,14)
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n/an/a 2.20E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332056
PNG
(CHEMBL1288244 | N-(2-methoxyethyl)-3-(2-phenylacet...)
Show SMILES COCCNC(=O)c1sccc1NC(=O)Cc1ccccc1
Show InChI InChI=1S/C16H18N2O3S/c1-21-9-8-17-16(20)15-13(7-10-22-15)18-14(19)11-12-5-3-2-4-6-12/h2-7,10H,8-9,11H2,1H3,(H,17,20)(H,18,19)
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n/an/a 2.30E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332073
PNG
(CHEMBL1287974 | N-(2-(5-methyl-1H-1,2,4-triazol-3-...)
Show SMILES Cc1nnc([nH]1)-c1sccc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C19H16N4OS/c1-12-20-19(23-22-12)18-16(9-10-25-18)21-17(24)11-14-7-4-6-13-5-2-3-8-15(13)14/h2-10H,11H2,1H3,(H,21,24)(H,20,22,23)
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n/an/a 2.40E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332088
PNG
(CHEMBL1288128 | N-(4-(1H-1,2,4-triazol-3-yl)thiazo...)
Show SMILES O=C(Cc1cccc2cnccc12)Nc1scnc1-c1nnc[nH]1
Show InChI InChI=1S/C16H12N6OS/c23-13(6-10-2-1-3-11-7-17-5-4-12(10)11)21-16-14(19-9-24-16)15-18-8-20-22-15/h1-5,7-9H,6H2,(H,21,23)(H,18,20,22)
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n/an/a 2.60E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332055
PNG
(3-(2-phenylacetamido)thiophene-2-carboxamide | CHE...)
Show SMILES NC(=O)c1sccc1NC(=O)Cc1ccccc1
Show InChI InChI=1S/C13H12N2O2S/c14-13(17)12-10(6-7-18-12)15-11(16)8-9-4-2-1-3-5-9/h1-7H,8H2,(H2,14,17)(H,15,16)
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n/an/a 2.60E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332041
PNG
(CHEMBL1288930 | methyl 3-(2-phenylacetamido)thioph...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1ccccc1
Show InChI InChI=1S/C14H13NO3S/c1-18-14(17)13-11(7-8-19-13)15-12(16)9-10-5-3-2-4-6-10/h2-8H,9H2,1H3,(H,15,16)
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n/an/a 2.70E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332051
PNG
(CHEMBL1288216 | methyl 3-(2-(quinolin-5-yl)acetami...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1cccc2ncccc12
Show InChI InChI=1S/C17H14N2O3S/c1-22-17(21)16-14(7-9-23-16)19-15(20)10-11-4-2-6-13-12(11)5-3-8-18-13/h2-9H,10H2,1H3,(H,19,20)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332070
PNG
(CHEMBL1287916 | N-(2-(1H-1,2,4-triazol-3-yl)thioph...)
Show SMILES O=C(Cc1cccc2ccccc12)Nc1ccsc1-c1nnc[nH]1
Show InChI InChI=1S/C18H14N4OS/c23-16(10-13-6-3-5-12-4-1-2-7-14(12)13)21-15-8-9-24-17(15)18-19-11-20-22-18/h1-9,11H,10H2,(H,21,23)(H,19,20,22)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332050
PNG
(CHEMBL1288215 | methyl 3-(2-(isoquinolin-5-yl)acet...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1cccc2cnccc12
Show InChI InChI=1S/C17H14N2O3S/c1-22-17(21)16-14(6-8-23-16)19-15(20)9-11-3-2-4-12-10-18-7-5-13(11)12/h2-8,10H,9H2,1H3,(H,19,20)
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n/an/a 3.10E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332069
PNG
(CHEMBL1287915 | N-(2-(1H-pyrazol-3-yl)thiophen-3-y...)
Show SMILES O=C(Cc1cccc2ccccc12)Nc1ccsc1-c1cc[nH]n1
Show InChI InChI=1S/C19H15N3OS/c23-18(12-14-6-3-5-13-4-1-2-7-15(13)14)21-16-9-11-24-19(16)17-8-10-20-22-17/h1-11H,12H2,(H,20,22)(H,21,23)
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n/an/a 3.20E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332067
PNG
(CHEMBL1287888 | N-(2-(1,3,4-oxadiazol-2-yl)thiophe...)
Show SMILES O=C(Cc1cccc2ccccc12)Nc1ccsc1-c1nnco1
Show InChI InChI=1S/C18H13N3O2S/c22-16(10-13-6-3-5-12-4-1-2-7-14(12)13)20-15-8-9-24-17(15)18-21-19-11-23-18/h1-9,11H,10H2,(H,20,22)
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n/an/a 3.20E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332075
PNG
(CHEMBL1288004 | N-(2-(5-methyl-1H-pyrazol-3-yl)thi...)
Show SMILES Cc1cc(n[nH]1)-c1sccc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C20H17N3OS/c1-13-11-18(23-22-13)20-17(9-10-25-20)21-19(24)12-15-7-4-6-14-5-2-3-8-16(14)15/h2-11H,12H2,1H3,(H,21,24)(H,22,23)
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n/an/a 3.40E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332079
PNG
(2-(4-methoxyphenyl)-N-(2-(5-(trifluoromethyl)-1H-1...)
Show SMILES COc1ccc(CC(=O)Nc2ccsc2-c2nnc([nH]2)C(F)(F)F)cc1
Show InChI InChI=1S/C16H13F3N4O2S/c1-25-10-4-2-9(3-5-10)8-12(24)20-11-6-7-26-13(11)14-21-15(23-22-14)16(17,18)19/h2-7H,8H2,1H3,(H,20,24)(H,21,22,23)
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n/an/a 3.40E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332069
PNG
(CHEMBL1287915 | N-(2-(1H-pyrazol-3-yl)thiophen-3-y...)
Show SMILES O=C(Cc1cccc2ccccc12)Nc1ccsc1-c1cc[nH]n1
Show InChI InChI=1S/C19H15N3OS/c23-18(12-14-6-3-5-13-4-1-2-7-15(13)14)21-16-9-11-24-19(16)17-8-10-20-22-17/h1-11H,12H2,(H,20,22)(H,21,23)
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n/an/a 3.60E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332056
PNG
(CHEMBL1288244 | N-(2-methoxyethyl)-3-(2-phenylacet...)
Show SMILES COCCNC(=O)c1sccc1NC(=O)Cc1ccccc1
Show InChI InChI=1S/C16H18N2O3S/c1-21-9-8-17-16(20)15-13(7-10-22-15)18-14(19)11-12-5-3-2-4-6-12/h2-7,10H,8-9,11H2,1H3,(H,17,20)(H,18,19)
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n/an/a 3.80E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332047
PNG
(CHEMBL1288187 | methyl 3-(2-(naphthalen-2-yl)aceta...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1ccc2ccccc2c1
Show InChI InChI=1S/C18H15NO3S/c1-22-18(21)17-15(8-9-23-17)19-16(20)11-12-6-7-13-4-2-3-5-14(13)10-12/h2-10H,11H2,1H3,(H,19,20)
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n/an/a 3.90E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332055
PNG
(3-(2-phenylacetamido)thiophene-2-carboxamide | CHE...)
Show SMILES NC(=O)c1sccc1NC(=O)Cc1ccccc1
Show InChI InChI=1S/C13H12N2O2S/c14-13(17)12-10(6-7-18-12)15-11(16)8-9-4-2-1-3-5-9/h1-7H,8H2,(H2,14,17)(H,15,16)
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n/an/a 4.40E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332077
PNG
(CHEMBL1288006 | N-(2-(2H-1,2,3-triazol-2-yl)thioph...)
Show SMILES COc1ccc(CC(=O)Nc2ccsc2-n2nccn2)cc1
Show InChI InChI=1S/C15H14N4O2S/c1-21-12-4-2-11(3-5-12)10-14(20)18-13-6-9-22-15(13)19-16-7-8-17-19/h2-9H,10H2,1H3,(H,18,20)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332087
PNG
(CHEMBL1288127 | methyl 5-(2-(isoquinolin-5-yl)acet...)
Show SMILES COC(=O)c1ncsc1NC(=O)Cc1cccc2cnccc12
Show InChI InChI=1S/C16H13N3O3S/c1-22-16(21)14-15(23-9-18-14)19-13(20)7-10-3-2-4-11-8-17-6-5-12(10)11/h2-6,8-9H,7H2,1H3,(H,19,20)
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n/an/a 5.30E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332067
PNG
(CHEMBL1287888 | N-(2-(1,3,4-oxadiazol-2-yl)thiophe...)
Show SMILES O=C(Cc1cccc2ccccc12)Nc1ccsc1-c1nnco1
Show InChI InChI=1S/C18H13N3O2S/c22-16(10-13-6-3-5-12-4-1-2-7-14(12)13)20-15-8-9-24-17(15)18-21-19-11-23-18/h1-9,11H,10H2,(H,20,22)
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n/an/a 5.30E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332065
PNG
(CHEMBL1287886 | methyl 4-(2-(naphthalen-1-yl)aceta...)
Show SMILES COC(=O)c1[nH]ncc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C17H15N3O3/c1-23-17(22)16-14(10-18-20-16)19-15(21)9-12-7-4-6-11-5-2-3-8-13(11)12/h2-8,10H,9H2,1H3,(H,18,20)(H,19,21)
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n/an/a 5.40E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332084
PNG
(2-(4-methoxyphenyl)-N-(2-(pyrazin-2-yl)thiophen-3-...)
Show SMILES COc1ccc(CC(=O)Nc2ccsc2-c2cnccn2)cc1
Show InChI InChI=1S/C17H15N3O2S/c1-22-13-4-2-12(3-5-13)10-16(21)20-14-6-9-23-17(14)15-11-18-7-8-19-15/h2-9,11H,10H2,1H3,(H,20,21)
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n/an/a 5.70E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332079
PNG
(2-(4-methoxyphenyl)-N-(2-(5-(trifluoromethyl)-1H-1...)
Show SMILES COc1ccc(CC(=O)Nc2ccsc2-c2nnc([nH]2)C(F)(F)F)cc1
Show InChI InChI=1S/C16H13F3N4O2S/c1-25-10-4-2-9(3-5-10)8-12(24)20-11-6-7-26-13(11)14-21-15(23-22-14)16(17,18)19/h2-7H,8H2,1H3,(H,20,24)(H,21,22,23)
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n/an/a 5.90E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332052
PNG
(CHEMBL1288932 | N-(2-acetylthiophen-3-yl)-2-phenyl...)
Show SMILES CC(=O)c1sccc1NC(=O)Cc1ccccc1
Show InChI InChI=1S/C14H13NO2S/c1-10(16)14-12(7-8-18-14)15-13(17)9-11-5-3-2-4-6-11/h2-8H,9H2,1H3,(H,15,17)
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n/an/a 6.30E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332066
PNG
(CHEMBL1287887 | methyl 4-(2-(naphthalen-1-yl)aceta...)
Show SMILES COC(=O)c1cnccc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C19H16N2O3/c1-24-19(23)16-12-20-10-9-17(16)21-18(22)11-14-7-4-6-13-5-2-3-8-15(13)14/h2-10,12H,11H2,1H3,(H,20,21,22)
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n/an/a 6.40E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332066
PNG
(CHEMBL1287887 | methyl 4-(2-(naphthalen-1-yl)aceta...)
Show SMILES COC(=O)c1cnccc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C19H16N2O3/c1-24-19(23)16-12-20-10-9-17(16)21-18(22)11-14-7-4-6-13-5-2-3-8-15(13)14/h2-10,12H,11H2,1H3,(H,20,21,22)
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n/an/a 6.50E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332042
PNG
(CHEMBL1288931 | methyl 3-(2-(pyridin-4-yl)acetamid...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1ccncc1
Show InChI InChI=1S/C13H12N2O3S/c1-18-13(17)12-10(4-7-19-12)15-11(16)8-9-2-5-14-6-3-9/h2-7H,8H2,1H3,(H,15,16)
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n/an/a 6.60E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332046
PNG
(CHEMBL1288186 | methyl 3-(2-(4-(trifluoromethyl)ph...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C15H12F3NO3S/c1-22-14(21)13-11(6-7-23-13)19-12(20)8-9-2-4-10(5-3-9)15(16,17)18/h2-7H,8H2,1H3,(H,19,20)
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n/an/a 6.90E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332049
PNG
(CHEMBL1288214 | methyl 3-(2-(2-(1H-1,2,3-triazol-4...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1ccccc1-c1c[nH]nn1
Show InChI InChI=1S/C16H14N4O3S/c1-23-16(22)15-12(6-7-24-15)18-14(21)8-10-4-2-3-5-11(10)13-9-17-20-19-13/h2-7,9H,8H2,1H3,(H,18,21)(H,17,19,20)
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n/an/a 7.00E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332089
PNG
(2-(isoquinolin-5-yl)-N-(4-(1-methyl-1H-1,2,4-triaz...)
Show SMILES Cn1ncnc1-c1ncsc1NC(=O)Cc1cccc2cnccc12
Show InChI InChI=1S/C17H14N6OS/c1-23-16(19-9-21-23)15-17(25-10-20-15)22-14(24)7-11-3-2-4-12-8-18-6-5-13(11)12/h2-6,8-10H,7H2,1H3,(H,22,24)
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n/an/a 7.60E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332080
PNG
(CHEMBL1288039 | N-(2-(5-amino-1H-1,2,4-triazol-3-y...)
Show SMILES COc1ccc(CC(=O)Nc2ccsc2-c2nnc(N)[nH]2)cc1
Show InChI InChI=1S/C15H15N5O2S/c1-22-10-4-2-9(3-5-10)8-12(21)17-11-6-7-23-13(11)14-18-15(16)20-19-14/h2-7H,8H2,1H3,(H,17,21)(H3,16,18,19,20)
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n/an/a 8.70E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332068
PNG
(CHEMBL1287914 | N-(2-(1H-imidazol-1-yl)thiophen-3-...)
Show SMILES O=C(Cc1cccc2ccccc12)Nc1ccsc1-n1ccnc1
Show InChI InChI=1S/C19H15N3OS/c23-18(12-15-6-3-5-14-4-1-2-7-16(14)15)21-17-8-11-24-19(17)22-10-9-20-13-22/h1-11,13H,12H2,(H,21,23)
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n/an/a 9.00E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332075
PNG
(CHEMBL1288004 | N-(2-(5-methyl-1H-pyrazol-3-yl)thi...)
Show SMILES Cc1cc(n[nH]1)-c1sccc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C20H17N3OS/c1-13-11-18(23-22-13)20-17(9-10-25-20)21-19(24)12-15-7-4-6-14-5-2-3-8-16(14)15/h2-11H,12H2,1H3,(H,21,24)(H,22,23)
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n/an/a 9.40E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332064
PNG
(CHEMBL1287859 | methyl 4-(2-(naphthalen-1-yl)aceta...)
Show SMILES COC(=O)c1cscc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C18H15NO3S/c1-22-18(21)15-10-23-11-16(15)19-17(20)9-13-7-4-6-12-5-2-3-8-14(12)13/h2-8,10-11H,9H2,1H3,(H,19,20)
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n/an/a 9.90E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332082
PNG
(2-(4-methoxyphenyl)-N-(2-(oxazol-2-yl)thiophen-3-y...)
Show SMILES COc1ccc(CC(=O)Nc2ccsc2-c2ncco2)cc1
Show InChI InChI=1S/C16H14N2O3S/c1-20-12-4-2-11(3-5-12)10-14(19)18-13-6-9-22-15(13)16-17-7-8-21-16/h2-9H,10H2,1H3,(H,18,19)
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n/an/a 1.19E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332049
PNG
(CHEMBL1288214 | methyl 3-(2-(2-(1H-1,2,3-triazol-4...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1ccccc1-c1c[nH]nn1
Show InChI InChI=1S/C16H14N4O3S/c1-23-16(22)15-12(6-7-24-15)18-14(21)8-10-4-2-3-5-11(10)13-9-17-20-19-13/h2-7,9H,8H2,1H3,(H,18,21)(H,17,19,20)
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n/an/a 1.26E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332063
PNG
(CHEMBL1287858 | methyl 2-(2-(naphthalen-1-yl)aceta...)
Show SMILES COC(=O)c1ccccc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C20H17NO3/c1-24-20(23)17-11-4-5-12-18(17)21-19(22)13-15-9-6-8-14-7-2-3-10-16(14)15/h2-12H,13H2,1H3,(H,21,22)
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n/an/a 1.31E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332043
PNG
(CHEMBL1288156 | methyl 3-(2-(4-methoxyphenyl)aceta...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1ccc(OC)cc1
Show InChI InChI=1S/C15H15NO4S/c1-19-11-5-3-10(4-6-11)9-13(17)16-12-7-8-21-14(12)15(18)20-2/h3-8H,9H2,1-2H3,(H,16,17)
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n/an/a 1.41E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332048
PNG
(CHEMBL1288188 | methyl 3-(2-(naphthalen-1-yl)aceta...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C18H15NO3S/c1-22-18(21)17-15(9-10-23-17)19-16(20)11-13-7-4-6-12-5-2-3-8-14(12)13/h2-10H,11H2,1H3,(H,19,20)
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n/an/a 1.46E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332079
PNG
(2-(4-methoxyphenyl)-N-(2-(5-(trifluoromethyl)-1H-1...)
Show SMILES COc1ccc(CC(=O)Nc2ccsc2-c2nnc([nH]2)C(F)(F)F)cc1
Show InChI InChI=1S/C16H13F3N4O2S/c1-25-10-4-2-9(3-5-10)8-12(24)20-11-6-7-26-13(11)14-21-15(23-22-14)16(17,18)19/h2-7H,8H2,1H3,(H,20,24)(H,21,22,23)
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n/an/a 1.50E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332071
PNG
(CHEMBL1287944 | N-(2-(5-methyl-1,3,4-oxadiazol-2-y...)
Show SMILES Cc1nnc(o1)-c1sccc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C19H15N3O2S/c1-12-21-22-19(24-12)18-16(9-10-25-18)20-17(23)11-14-7-4-6-13-5-2-3-8-15(13)14/h2-10H,11H2,1H3,(H,20,23)
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n/an/a 1.63E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332052
PNG
(CHEMBL1288932 | N-(2-acetylthiophen-3-yl)-2-phenyl...)
Show SMILES CC(=O)c1sccc1NC(=O)Cc1ccccc1
Show InChI InChI=1S/C14H13NO2S/c1-10(16)14-12(7-8-18-14)15-13(17)9-11-5-3-2-4-6-11/h2-8H,9H2,1H3,(H,15,17)
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n/an/a 1.70E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332042
PNG
(CHEMBL1288931 | methyl 3-(2-(pyridin-4-yl)acetamid...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1ccncc1
Show InChI InChI=1S/C13H12N2O3S/c1-18-13(17)12-10(4-7-19-12)15-11(16)8-9-2-5-14-6-3-9/h2-7H,8H2,1H3,(H,15,16)
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n/an/a 1.72E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332040
PNG
(CHEMBL1288895 | methyl 3-(2-(thiophen-2-yl)acetami...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1cccs1
Show InChI InChI=1S/C12H11NO3S2/c1-16-12(15)11-9(4-6-18-11)13-10(14)7-8-3-2-5-17-8/h2-6H,7H2,1H3,(H,13,14)
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n/an/a 2.14E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332041
PNG
(CHEMBL1288930 | methyl 3-(2-phenylacetamido)thioph...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1ccccc1
Show InChI InChI=1S/C14H13NO3S/c1-18-14(17)13-11(7-8-19-13)15-12(16)9-10-5-3-2-4-6-10/h2-8H,9H2,1H3,(H,15,16)
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n/an/a 2.28E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332083
PNG
(2-(4-methoxyphenyl)-N-(2-(2-methyl-1H-imidazol-4-y...)
Show SMILES COc1ccc(CC(=O)Nc2ccsc2-c2c[nH]c(C)n2)cc1
Show InChI InChI=1S/C17H17N3O2S/c1-11-18-10-15(19-11)17-14(7-8-23-17)20-16(21)9-12-3-5-13(22-2)6-4-12/h3-8,10H,9H2,1-2H3,(H,18,19)(H,20,21)
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n/an/a 2.34E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332066
PNG
(CHEMBL1287887 | methyl 4-(2-(naphthalen-1-yl)aceta...)
Show SMILES COC(=O)c1cnccc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C19H16N2O3/c1-24-19(23)16-12-20-10-9-17(16)21-18(22)11-14-7-4-6-13-5-2-3-8-15(13)14/h2-10,12H,11H2,1H3,(H,20,21,22)
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n/an/a 2.36E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332081
PNG
(2-(4-methoxyphenyl)-N-(2-(1-methyl-1H-imidazol-4-y...)
Show SMILES COc1ccc(CC(=O)Nc2ccsc2-c2cn(C)cn2)cc1
Show InChI InChI=1S/C17H17N3O2S/c1-20-10-15(18-11-20)17-14(7-8-23-17)19-16(21)9-12-3-5-13(22-2)6-4-12/h3-8,10-11H,9H2,1-2H3,(H,19,21)
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n/an/a 2.39E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50332088
PNG
(CHEMBL1288128 | N-(4-(1H-1,2,4-triazol-3-yl)thiazo...)
Show SMILES O=C(Cc1cccc2cnccc12)Nc1scnc1-c1nnc[nH]1
Show InChI InChI=1S/C16H12N6OS/c23-13(6-10-2-1-3-11-7-17-5-4-12(10)11)21-16-14(19-9-24-16)15-18-8-20-22-15/h1-5,7-9H,6H2,(H,21,23)(H,18,20,22)
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n/an/a 2.40E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant Erk2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332072
PNG
(CHEMBL1287945 | N-(2-(1-methyl-1H-pyrazol-3-yl)thi...)
Show SMILES Cn1ccc(n1)-c1sccc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C20H17N3OS/c1-23-11-9-18(22-23)20-17(10-12-25-20)21-19(24)13-15-7-4-6-14-5-2-3-8-16(14)15/h2-12H,13H2,1H3,(H,21,24)
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n/an/a 2.41E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332065
PNG
(CHEMBL1287886 | methyl 4-(2-(naphthalen-1-yl)aceta...)
Show SMILES COC(=O)c1[nH]ncc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C17H15N3O3/c1-23-17(22)16-14(10-18-20-16)19-15(21)9-12-7-4-6-11-5-2-3-8-13(11)12/h2-8,10H,9H2,1H3,(H,18,20)(H,19,21)
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n/an/a 2.67E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332068
PNG
(CHEMBL1287914 | N-(2-(1H-imidazol-1-yl)thiophen-3-...)
Show SMILES O=C(Cc1cccc2ccccc12)Nc1ccsc1-n1ccnc1
Show InChI InChI=1S/C19H15N3OS/c23-18(12-15-6-3-5-14-4-1-2-7-16(14)15)21-17-8-11-24-19(17)22-10-9-20-13-22/h1-11,13H,12H2,(H,21,23)
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n/an/a 2.69E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332083
PNG
(2-(4-methoxyphenyl)-N-(2-(2-methyl-1H-imidazol-4-y...)
Show SMILES COc1ccc(CC(=O)Nc2ccsc2-c2c[nH]c(C)n2)cc1
Show InChI InChI=1S/C17H17N3O2S/c1-11-18-10-15(19-11)17-14(7-8-23-17)20-16(21)9-12-3-5-13(22-2)6-4-12/h3-8,10H,9H2,1-2H3,(H,18,19)(H,20,21)
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n/an/a 2.70E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332067
PNG
(CHEMBL1287888 | N-(2-(1,3,4-oxadiazol-2-yl)thiophe...)
Show SMILES O=C(Cc1cccc2ccccc12)Nc1ccsc1-c1nnco1
Show InChI InChI=1S/C18H13N3O2S/c22-16(10-13-6-3-5-12-4-1-2-7-14(12)13)20-15-8-9-24-17(15)18-21-19-11-23-18/h1-9,11H,10H2,(H,20,22)
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n/an/a 2.71E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332095
PNG
(CHEMBL1288964 | N-(2-(1-(hydroxyimino)ethyl)thioph...)
Show SMILES CC(N=O)c1sccc1NC(=O)Cc1ccccc1
Show InChI InChI=1S/C14H14N2O2S/c1-10(16-18)14-12(7-8-19-14)15-13(17)9-11-5-3-2-4-6-11/h2-8,10H,9H2,1H3,(H,15,17)
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n/an/a 2.90E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332074
PNG
(CHEMBL1287975 | N-(2-(1,3-dimethyl-1H-1,2,4-triazo...)
Show SMILES Cc1nc(-c2sccc2NC(=O)Cc2cccc3ccccc23)n(C)n1
Show InChI InChI=1S/C20H18N4OS/c1-13-21-20(24(2)23-13)19-17(10-11-26-19)22-18(25)12-15-8-5-7-14-6-3-4-9-16(14)15/h3-11H,12H2,1-2H3,(H,22,25)
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n/an/a 3.03E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332081
PNG
(2-(4-methoxyphenyl)-N-(2-(1-methyl-1H-imidazol-4-y...)
Show SMILES COc1ccc(CC(=O)Nc2ccsc2-c2cn(C)cn2)cc1
Show InChI InChI=1S/C17H17N3O2S/c1-20-10-15(18-11-20)17-14(7-8-23-17)19-16(21)9-12-3-5-13(22-2)6-4-12/h3-8,10-11H,9H2,1-2H3,(H,19,21)
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n/an/a 3.10E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332074
PNG
(CHEMBL1287975 | N-(2-(1,3-dimethyl-1H-1,2,4-triazo...)
Show SMILES Cc1nc(-c2sccc2NC(=O)Cc2cccc3ccccc23)n(C)n1
Show InChI InChI=1S/C20H18N4OS/c1-13-21-20(24(2)23-13)19-17(10-11-26-19)22-18(25)12-15-8-5-7-14-6-3-4-9-16(14)15/h3-11H,12H2,1-2H3,(H,22,25)
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n/an/a 3.15E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332049
PNG
(CHEMBL1288214 | methyl 3-(2-(2-(1H-1,2,3-triazol-4...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1ccccc1-c1c[nH]nn1
Show InChI InChI=1S/C16H14N4O3S/c1-23-16(22)15-12(6-7-24-15)18-14(21)8-10-4-2-3-5-11(10)13-9-17-20-19-13/h2-7,9H,8H2,1H3,(H,18,21)(H,17,19,20)
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n/an/a 3.50E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332078
PNG
(2-(4-methoxyphenyl)-N-(2-(2-oxooxazolidin-3-yl)thi...)
Show SMILES COc1ccc(CC(=O)Nc2ccsc2N2CCOC2=O)cc1
Show InChI InChI=1S/C16H16N2O4S/c1-21-12-4-2-11(3-5-12)10-14(19)17-13-6-9-23-15(13)18-7-8-22-16(18)20/h2-6,9H,7-8,10H2,1H3,(H,17,19)
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n/an/a 3.70E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332072
PNG
(CHEMBL1287945 | N-(2-(1-methyl-1H-pyrazol-3-yl)thi...)
Show SMILES Cn1ccc(n1)-c1sccc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C20H17N3OS/c1-23-11-9-18(22-23)20-17(10-12-25-20)21-19(24)13-15-7-4-6-14-5-2-3-8-16(14)15/h2-12H,13H2,1H3,(H,21,24)
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n/an/a 4.25E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332076
PNG
(CHEMBL1288005 | N-(2-(1H-1,2,4-triazol-1-yl)thioph...)
Show SMILES COc1ccc(CC(=O)Nc2ccsc2-n2cncn2)cc1
Show InChI InChI=1S/C15H14N4O2S/c1-21-12-4-2-11(3-5-12)8-14(20)18-13-6-7-22-15(13)19-10-16-9-17-19/h2-7,9-10H,8H2,1H3,(H,18,20)
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n/an/a 4.36E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332076
PNG
(CHEMBL1288005 | N-(2-(1H-1,2,4-triazol-1-yl)thioph...)
Show SMILES COc1ccc(CC(=O)Nc2ccsc2-n2cncn2)cc1
Show InChI InChI=1S/C15H14N4O2S/c1-21-12-4-2-11(3-5-12)8-14(20)18-13-6-7-22-15(13)19-10-16-9-17-19/h2-7,9-10H,8H2,1H3,(H,18,20)
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n/an/a 4.56E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332053
PNG
(CHEMBL1288966 | ethyl 3-(2-phenylacetamido)thiophe...)
Show SMILES CCOC(=O)c1sccc1NC(=O)Cc1ccccc1
Show InChI InChI=1S/C15H15NO3S/c1-2-19-15(18)14-12(8-9-20-14)16-13(17)10-11-6-4-3-5-7-11/h3-9H,2,10H2,1H3,(H,16,17)
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n/an/a 4.66E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332054
PNG
(CHEMBL1288243 | isopropyl 3-(2-phenylacetamido)thi...)
Show SMILES CC(C)OC(=O)c1sccc1NC(=O)Cc1ccccc1
Show InChI InChI=1S/C16H17NO3S/c1-11(2)20-16(19)15-13(8-9-21-15)17-14(18)10-12-6-4-3-5-7-12/h3-9,11H,10H2,1-2H3,(H,17,18)
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n/an/a 4.77E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332076
PNG
(CHEMBL1288005 | N-(2-(1H-1,2,4-triazol-1-yl)thioph...)
Show SMILES COc1ccc(CC(=O)Nc2ccsc2-n2cncn2)cc1
Show InChI InChI=1S/C15H14N4O2S/c1-21-12-4-2-11(3-5-12)8-14(20)18-13-6-7-22-15(13)19-10-16-9-17-19/h2-7,9-10H,8H2,1H3,(H,18,20)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50332086
PNG
(2-(isoquinolin-5-yl)-N-(2-(thiazol-4-yl)thiophen-3...)
Show SMILES O=C(Cc1cccc2cnccc12)Nc1ccsc1-c1cscn1
Show InChI InChI=1S/C18H13N3OS2/c22-17(8-12-2-1-3-13-9-19-6-4-14(12)13)21-15-5-7-24-18(15)16-10-23-11-20-16/h1-7,9-11H,8H2,(H,21,22)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50332091
PNG
(CHEMBL1288160 | N-(4,4'-bithiazol-5-yl)-2-(isoquin...)
Show SMILES O=C(Cc1cccc2cnccc12)Nc1scnc1-c1cscn1
Show InChI InChI=1S/C17H12N4OS2/c22-15(6-11-2-1-3-12-7-18-5-4-13(11)12)21-17-16(20-10-24-17)14-8-23-9-19-14/h1-5,7-10H,6H2,(H,21,22)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant Erk2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332042
PNG
(CHEMBL1288931 | methyl 3-(2-(pyridin-4-yl)acetamid...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1ccncc1
Show InChI InChI=1S/C13H12N2O3S/c1-18-13(17)12-10(4-7-19-12)15-11(16)8-9-2-5-14-6-3-9/h2-7H,8H2,1H3,(H,15,16)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332046
PNG
(CHEMBL1288186 | methyl 3-(2-(4-(trifluoromethyl)ph...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C15H12F3NO3S/c1-22-14(21)13-11(6-7-23-13)19-12(20)8-9-2-4-10(5-3-9)15(16,17)18/h2-7H,8H2,1H3,(H,19,20)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332069
PNG
(CHEMBL1287915 | N-(2-(1H-pyrazol-3-yl)thiophen-3-y...)
Show SMILES O=C(Cc1cccc2ccccc12)Nc1ccsc1-c1cc[nH]n1
Show InChI InChI=1S/C19H15N3OS/c23-18(12-14-6-3-5-13-4-1-2-7-15(13)14)21-16-9-11-24-19(16)17-8-10-20-22-17/h1-11H,12H2,(H,20,22)(H,21,23)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50332050
PNG
(CHEMBL1288215 | methyl 3-(2-(isoquinolin-5-yl)acet...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1cccc2cnccc12
Show InChI InChI=1S/C17H14N2O3S/c1-22-17(21)16-14(6-8-23-16)19-15(20)9-11-3-2-4-12-10-18-7-5-13(11)12/h2-8,10H,9H2,1H3,(H,19,20)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant Erk2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50332065
PNG
(CHEMBL1287886 | methyl 4-(2-(naphthalen-1-yl)aceta...)
Show SMILES COC(=O)c1[nH]ncc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C17H15N3O3/c1-23-17(22)16-14(10-18-20-16)19-15(21)9-12-7-4-6-11-5-2-3-8-13(11)12/h2-8,10H,9H2,1H3,(H,18,20)(H,19,21)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant Erk2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50332079
PNG
(2-(4-methoxyphenyl)-N-(2-(5-(trifluoromethyl)-1H-1...)
Show SMILES COc1ccc(CC(=O)Nc2ccsc2-c2nnc([nH]2)C(F)(F)F)cc1
Show InChI InChI=1S/C16H13F3N4O2S/c1-25-10-4-2-9(3-5-10)8-12(24)20-11-6-7-26-13(11)14-21-15(23-22-14)16(17,18)19/h2-7H,8H2,1H3,(H,20,24)(H,21,22,23)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50332083
PNG
(2-(4-methoxyphenyl)-N-(2-(2-methyl-1H-imidazol-4-y...)
Show SMILES COc1ccc(CC(=O)Nc2ccsc2-c2c[nH]c(C)n2)cc1
Show InChI InChI=1S/C17H17N3O2S/c1-11-18-10-15(19-11)17-14(7-8-23-17)20-16(21)9-12-3-5-13(22-2)6-4-12/h3-8,10H,9H2,1-2H3,(H,18,19)(H,20,21)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant Erk2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50332087
PNG
(CHEMBL1288127 | methyl 5-(2-(isoquinolin-5-yl)acet...)
Show SMILES COC(=O)c1ncsc1NC(=O)Cc1cccc2cnccc12
Show InChI InChI=1S/C16H13N3O3S/c1-22-16(21)14-15(23-9-18-14)19-13(20)7-10-3-2-4-11-8-17-6-5-12(10)11/h2-6,8-9H,7H2,1H3,(H,19,20)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332058
PNG
(CHEMBL1288272 | methyl 4-(2-(naphthalen-1-yl)aceta...)
Show SMILES COC(=O)c1nonc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C16H13N3O4/c1-22-16(21)14-15(19-23-18-14)17-13(20)9-11-7-4-6-10-5-2-3-8-12(10)11/h2-8H,9H2,1H3,(H,17,19,20)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332061
PNG
(CHEMBL1288298 | methyl 2-(2-(naphthalen-1-yl)aceta...)
Show SMILES COC(=O)c1cccnc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C19H16N2O3/c1-24-19(23)16-10-5-11-20-18(16)21-17(22)12-14-8-4-7-13-6-2-3-9-15(13)14/h2-11H,12H2,1H3,(H,20,21,22)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332072
PNG
(CHEMBL1287945 | N-(2-(1-methyl-1H-pyrazol-3-yl)thi...)
Show SMILES Cn1ccc(n1)-c1sccc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C20H17N3OS/c1-23-11-9-18(22-23)20-17(10-12-25-20)21-19(24)13-15-7-4-6-14-5-2-3-8-16(14)15/h2-12H,13H2,1H3,(H,21,24)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332057
PNG
(CHEMBL1288271 | methyl 5-(2-(naphthalen-1-yl)aceta...)
Show SMILES COC(=O)c1nnsc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C16H13N3O3S/c1-22-16(21)14-15(23-19-18-14)17-13(20)9-11-7-4-6-10-5-2-3-8-12(10)11/h2-8H,9H2,1H3,(H,17,20)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332058
PNG
(CHEMBL1288272 | methyl 4-(2-(naphthalen-1-yl)aceta...)
Show SMILES COC(=O)c1nonc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C16H13N3O4/c1-22-16(21)14-15(19-23-18-14)17-13(20)9-11-7-4-6-10-5-2-3-8-12(10)11/h2-8H,9H2,1H3,(H,17,19,20)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332059
PNG
(CHEMBL1288273 | ethyl 3-methyl-5-(2-(naphthalen-1-...)
Show SMILES CCOC(=O)c1c(C)nsc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C19H18N2O3S/c1-3-24-19(23)17-12(2)21-25-18(17)20-16(22)11-14-9-6-8-13-7-4-5-10-15(13)14/h4-10H,3,11H2,1-2H3,(H,20,22)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50332089
PNG
(2-(isoquinolin-5-yl)-N-(4-(1-methyl-1H-1,2,4-triaz...)
Show SMILES Cn1ncnc1-c1ncsc1NC(=O)Cc1cccc2cnccc12
Show InChI InChI=1S/C17H14N6OS/c1-23-16(19-9-21-23)15-17(25-10-20-15)22-14(24)7-11-3-2-4-12-8-18-6-5-13(11)12/h2-6,8-10H,7H2,1H3,(H,22,24)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant Erk2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50332090
PNG
(2-(isoquinolin-5-yl)-N-(4-(pyrazin-2-yl)thiazol-5-...)
Show SMILES O=C(Cc1cccc2cnccc12)Nc1scnc1-c1cnccn1
Show InChI InChI=1S/C18H13N5OS/c24-16(8-12-2-1-3-13-9-19-5-4-14(12)13)23-18-17(22-11-25-18)15-10-20-6-7-21-15/h1-7,9-11H,8H2,(H,23,24)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant Erk2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332045
PNG
(CHEMBL1288158 | methyl 3-(2-(4-(1H-imidazol-1-yl)p...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1ccc(cc1)-n1ccnc1
Show InChI InChI=1S/C17H15N3O3S/c1-23-17(22)16-14(6-9-24-16)19-15(21)10-12-2-4-13(5-3-12)20-8-7-18-11-20/h2-9,11H,10H2,1H3,(H,19,21)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332055
PNG
(3-(2-phenylacetamido)thiophene-2-carboxamide | CHE...)
Show SMILES NC(=O)c1sccc1NC(=O)Cc1ccccc1
Show InChI InChI=1S/C13H12N2O2S/c14-13(17)12-10(6-7-18-12)15-11(16)8-9-4-2-1-3-5-9/h1-7H,8H2,(H2,14,17)(H,15,16)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50332086
PNG
(2-(isoquinolin-5-yl)-N-(2-(thiazol-4-yl)thiophen-3...)
Show SMILES O=C(Cc1cccc2cnccc12)Nc1ccsc1-c1cscn1
Show InChI InChI=1S/C18H13N3OS2/c22-17(8-12-2-1-3-13-9-19-6-4-14(12)13)21-15-5-7-24-18(15)16-10-23-11-20-16/h1-7,9-11H,8H2,(H,21,22)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant Erk2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332078
PNG
(2-(4-methoxyphenyl)-N-(2-(2-oxooxazolidin-3-yl)thi...)
Show SMILES COc1ccc(CC(=O)Nc2ccsc2N2CCOC2=O)cc1
Show InChI InChI=1S/C16H16N2O4S/c1-21-12-4-2-11(3-5-12)10-14(19)17-13-6-9-23-15(13)18-7-8-22-16(18)20/h2-6,9H,7-8,10H2,1H3,(H,17,19)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332047
PNG
(CHEMBL1288187 | methyl 3-(2-(naphthalen-2-yl)aceta...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1ccc2ccccc2c1
Show InChI InChI=1S/C18H15NO3S/c1-22-18(21)17-15(8-9-23-17)19-16(20)11-12-6-7-13-4-2-3-5-14(13)10-12/h2-10H,11H2,1H3,(H,19,20)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332092
PNG
(CHEMBL1288245 | N-(2-methoxyethyl)-N-methyl-3-(2-p...)
Show SMILES COCCN(C)C(=O)c1sccc1NC(=O)Cc1ccccc1
Show InChI InChI=1S/C17H20N2O3S/c1-19(9-10-22-2)17(21)16-14(8-11-23-16)18-15(20)12-13-6-4-3-5-7-13/h3-8,11H,9-10,12H2,1-2H3,(H,18,20)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332060
PNG
(CHEMBL1288297 | methyl 4-(2-(naphthalen-1-yl)aceta...)
Show SMILES COC(=O)c1scnc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C17H14N2O3S/c1-22-17(21)15-16(18-10-23-15)19-14(20)9-12-7-4-6-11-5-2-3-8-13(11)12/h2-8,10H,9H2,1H3,(H,19,20)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332068
PNG
(CHEMBL1287914 | N-(2-(1H-imidazol-1-yl)thiophen-3-...)
Show SMILES O=C(Cc1cccc2ccccc12)Nc1ccsc1-n1ccnc1
Show InChI InChI=1S/C19H15N3OS/c23-18(12-15-6-3-5-14-4-1-2-7-16(14)15)21-17-8-11-24-19(17)22-10-9-20-13-22/h1-11,13H,12H2,(H,21,23)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332060
PNG
(CHEMBL1288297 | methyl 4-(2-(naphthalen-1-yl)aceta...)
Show SMILES COC(=O)c1scnc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C17H14N2O3S/c1-22-17(21)15-16(18-10-23-15)19-14(20)9-12-7-4-6-11-5-2-3-8-13(11)12/h2-8,10H,9H2,1H3,(H,19,20)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332061
PNG
(CHEMBL1288298 | methyl 2-(2-(naphthalen-1-yl)aceta...)
Show SMILES COC(=O)c1cccnc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C19H16N2O3/c1-24-19(23)16-10-5-11-20-18(16)21-17(22)12-14-8-4-7-13-6-2-3-9-15(13)14/h2-11H,12H2,1H3,(H,20,21,22)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332094
PNG
(CHEMBL1288933 | N-(2-(hydroxymethyl)thiophen-3-yl)...)
Show SMILES OCc1sccc1NC(=O)Cc1ccccc1
Show InChI InChI=1S/C13H13NO2S/c15-9-12-11(6-7-17-12)14-13(16)8-10-4-2-1-3-5-10/h1-7,15H,8-9H2,(H,14,16)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50332050
PNG
(CHEMBL1288215 | methyl 3-(2-(isoquinolin-5-yl)acet...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1cccc2cnccc12
Show InChI InChI=1S/C17H14N2O3S/c1-22-17(21)16-14(6-8-23-16)19-15(20)9-11-3-2-4-12-10-18-7-5-13(11)12/h2-8,10H,9H2,1H3,(H,19,20)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50332080
PNG
(CHEMBL1288039 | N-(2-(5-amino-1H-1,2,4-triazol-3-y...)
Show SMILES COc1ccc(CC(=O)Nc2ccsc2-c2nnc(N)[nH]2)cc1
Show InChI InChI=1S/C15H15N5O2S/c1-22-10-4-2-9(3-5-10)8-12(21)17-11-6-7-23-13(11)14-18-15(16)20-19-14/h2-7H,8H2,1H3,(H,17,21)(H3,16,18,19,20)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant Erk2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50332084
PNG
(2-(4-methoxyphenyl)-N-(2-(pyrazin-2-yl)thiophen-3-...)
Show SMILES COc1ccc(CC(=O)Nc2ccsc2-c2cnccn2)cc1
Show InChI InChI=1S/C17H15N3O2S/c1-22-13-4-2-12(3-5-13)10-16(21)20-14-6-9-23-17(14)15-11-18-7-8-19-15/h2-9,11H,10H2,1H3,(H,20,21)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50332085
PNG
(CHEMBL1288099 | N-(2-(4H-1,2,4-triazol-3-yl)thioph...)
Show SMILES O=C(Cc1cccc2ncccc12)Nc1ccsc1-c1nnc[nH]1
Show InChI InChI=1S/C17H13N5OS/c23-15(9-11-3-1-5-13-12(11)4-2-7-18-13)21-14-6-8-24-16(14)17-19-10-20-22-17/h1-8,10H,9H2,(H,21,23)(H,19,20,22)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant Erk2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332058
PNG
(CHEMBL1288272 | methyl 4-(2-(naphthalen-1-yl)aceta...)
Show SMILES COC(=O)c1nonc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C16H13N3O4/c1-22-16(21)14-15(19-23-18-14)17-13(20)9-11-7-4-6-10-5-2-3-8-12(10)11/h2-8H,9H2,1H3,(H,17,19,20)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332059
PNG
(CHEMBL1288273 | ethyl 3-methyl-5-(2-(naphthalen-1-...)
Show SMILES CCOC(=O)c1c(C)nsc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C19H18N2O3S/c1-3-24-19(23)17-12(2)21-25-18(17)20-16(22)11-14-9-6-8-13-7-4-5-10-15(13)14/h4-10H,3,11H2,1-2H3,(H,20,22)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332060
PNG
(CHEMBL1288297 | methyl 4-(2-(naphthalen-1-yl)aceta...)
Show SMILES COC(=O)c1scnc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C17H14N2O3S/c1-22-17(21)15-16(18-10-23-15)19-14(20)9-12-7-4-6-11-5-2-3-8-13(11)12/h2-8,10H,9H2,1H3,(H,19,20)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332052
PNG
(CHEMBL1288932 | N-(2-acetylthiophen-3-yl)-2-phenyl...)
Show SMILES CC(=O)c1sccc1NC(=O)Cc1ccccc1
Show InChI InChI=1S/C14H13NO2S/c1-10(16)14-12(7-8-18-14)15-13(17)9-11-5-3-2-4-6-11/h2-8H,9H2,1H3,(H,15,17)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332056
PNG
(CHEMBL1288244 | N-(2-methoxyethyl)-3-(2-phenylacet...)
Show SMILES COCCNC(=O)c1sccc1NC(=O)Cc1ccccc1
Show InChI InChI=1S/C16H18N2O3S/c1-21-9-8-17-16(20)15-13(7-10-22-15)18-14(19)11-12-5-3-2-4-6-12/h2-7,10H,8-9,11H2,1H3,(H,17,20)(H,18,19)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332057
PNG
(CHEMBL1288271 | methyl 5-(2-(naphthalen-1-yl)aceta...)
Show SMILES COC(=O)c1nnsc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C16H13N3O3S/c1-22-16(21)14-15(23-19-18-14)17-13(20)9-11-7-4-6-10-5-2-3-8-12(10)11/h2-8H,9H2,1H3,(H,17,20)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332062
PNG
(CHEMBL1288299 | N-(4-methylpyridin-3-yl)-2-(naphth...)
Show SMILES Cc1ccncc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C18H16N2O/c1-13-9-10-19-12-17(13)20-18(21)11-15-7-4-6-14-5-2-3-8-16(14)15/h2-10,12H,11H2,1H3,(H,20,21)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332092
PNG
(CHEMBL1288245 | N-(2-methoxyethyl)-N-methyl-3-(2-p...)
Show SMILES COCCN(C)C(=O)c1sccc1NC(=O)Cc1ccccc1
Show InChI InChI=1S/C17H20N2O3S/c1-19(9-10-22-2)17(21)16-14(8-11-23-16)18-15(20)12-13-6-4-3-5-7-13/h3-8,11H,9-10,12H2,1-2H3,(H,18,20)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332062
PNG
(CHEMBL1288299 | N-(4-methylpyridin-3-yl)-2-(naphth...)
Show SMILES Cc1ccncc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C18H16N2O/c1-13-9-10-19-12-17(13)20-18(21)11-15-7-4-6-14-5-2-3-8-16(14)15/h2-10,12H,11H2,1H3,(H,20,21)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332096
PNG
(2-phenyl-N-(2-(prop-1-en-2-yl)thiophen-3-yl)acetam...)
Show SMILES CC(=C)c1sccc1NC(=O)Cc1ccccc1
Show InChI InChI=1S/C15H15NOS/c1-11(2)15-13(8-9-18-15)16-14(17)10-12-6-4-3-5-7-12/h3-9H,1,10H2,2H3,(H,16,17)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50332088
PNG
(CHEMBL1288128 | N-(4-(1H-1,2,4-triazol-3-yl)thiazo...)
Show SMILES O=C(Cc1cccc2cnccc12)Nc1scnc1-c1nnc[nH]1
Show InChI InChI=1S/C16H12N6OS/c23-13(6-10-2-1-3-11-7-17-5-4-12(10)11)21-16-14(19-9-24-16)15-18-8-20-22-15/h1-5,7-9H,6H2,(H,21,23)(H,18,20,22)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50332081
PNG
(2-(4-methoxyphenyl)-N-(2-(1-methyl-1H-imidazol-4-y...)
Show SMILES COc1ccc(CC(=O)Nc2ccsc2-c2cn(C)cn2)cc1
Show InChI InChI=1S/C17H17N3O2S/c1-20-10-15(18-11-20)17-14(7-8-23-17)19-16(21)9-12-3-5-13(22-2)6-4-12/h3-8,10-11H,9H2,1-2H3,(H,19,21)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50332083
PNG
(2-(4-methoxyphenyl)-N-(2-(2-methyl-1H-imidazol-4-y...)
Show SMILES COc1ccc(CC(=O)Nc2ccsc2-c2c[nH]c(C)n2)cc1
Show InChI InChI=1S/C17H17N3O2S/c1-11-18-10-15(19-11)17-14(7-8-23-17)20-16(21)9-12-3-5-13(22-2)6-4-12/h3-8,10H,9H2,1-2H3,(H,18,19)(H,20,21)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50332084
PNG
(2-(4-methoxyphenyl)-N-(2-(pyrazin-2-yl)thiophen-3-...)
Show SMILES COc1ccc(CC(=O)Nc2ccsc2-c2cnccn2)cc1
Show InChI InChI=1S/C17H15N3O2S/c1-22-13-4-2-12(3-5-13)10-16(21)20-14-6-9-23-17(14)15-11-18-7-8-19-15/h2-9,11H,10H2,1H3,(H,20,21)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant Erk2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50332089
PNG
(2-(isoquinolin-5-yl)-N-(4-(1-methyl-1H-1,2,4-triaz...)
Show SMILES Cn1ncnc1-c1ncsc1NC(=O)Cc1cccc2cnccc12
Show InChI InChI=1S/C17H14N6OS/c1-23-16(19-9-21-23)15-17(25-10-20-15)22-14(24)7-11-3-2-4-12-8-18-6-5-13(11)12/h2-6,8-10H,7H2,1H3,(H,22,24)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332061
PNG
(CHEMBL1288298 | methyl 2-(2-(naphthalen-1-yl)aceta...)
Show SMILES COC(=O)c1cccnc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C19H16N2O3/c1-24-19(23)16-10-5-11-20-18(16)21-17(22)12-14-8-4-7-13-6-2-3-9-15(13)14/h2-11H,12H2,1H3,(H,20,21,22)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332062
PNG
(CHEMBL1288299 | N-(4-methylpyridin-3-yl)-2-(naphth...)
Show SMILES Cc1ccncc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C18H16N2O/c1-13-9-10-19-12-17(13)20-18(21)11-15-7-4-6-14-5-2-3-8-16(14)15/h2-10,12H,11H2,1H3,(H,20,21)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332044
PNG
(CHEMBL1288157 | methyl 3-(2-(4-(pyridin-4-yl)pheny...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1ccc(cc1)-c1ccncc1
Show InChI InChI=1S/C19H16N2O3S/c1-24-19(23)18-16(8-11-25-18)21-17(22)12-13-2-4-14(5-3-13)15-6-9-20-10-7-15/h2-11H,12H2,1H3,(H,21,22)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332093
PNG
(CHEMBL1287857 | N-(3-methylpyrazin-2-yl)-2-(naphth...)
Show SMILES Cc1nccnc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C17H15N3O/c1-12-17(19-10-9-18-12)20-16(21)11-14-7-4-6-13-5-2-3-8-15(13)14/h2-10H,11H2,1H3,(H,19,20,21)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332078
PNG
(2-(4-methoxyphenyl)-N-(2-(2-oxooxazolidin-3-yl)thi...)
Show SMILES COc1ccc(CC(=O)Nc2ccsc2N2CCOC2=O)cc1
Show InChI InChI=1S/C16H16N2O4S/c1-21-12-4-2-11(3-5-12)10-14(19)17-13-6-9-23-15(13)18-7-8-22-16(18)20/h2-6,9H,7-8,10H2,1H3,(H,17,19)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332081
PNG
(2-(4-methoxyphenyl)-N-(2-(1-methyl-1H-imidazol-4-y...)
Show SMILES COc1ccc(CC(=O)Nc2ccsc2-c2cn(C)cn2)cc1
Show InChI InChI=1S/C17H17N3O2S/c1-20-10-15(18-11-20)17-14(7-8-23-17)19-16(21)9-12-3-5-13(22-2)6-4-12/h3-8,10-11H,9H2,1-2H3,(H,19,21)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332093
PNG
(CHEMBL1287857 | N-(3-methylpyrazin-2-yl)-2-(naphth...)
Show SMILES Cc1nccnc1NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C17H15N3O/c1-12-17(19-10-9-18-12)20-16(21)11-14-7-4-6-13-5-2-3-8-15(13)14/h2-10H,11H2,1H3,(H,19,20,21)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50332079
PNG
(2-(4-methoxyphenyl)-N-(2-(5-(trifluoromethyl)-1H-1...)
Show SMILES COc1ccc(CC(=O)Nc2ccsc2-c2nnc([nH]2)C(F)(F)F)cc1
Show InChI InChI=1S/C16H13F3N4O2S/c1-25-10-4-2-9(3-5-10)8-12(24)20-11-6-7-26-13(11)14-21-15(23-22-14)16(17,18)19/h2-7H,8H2,1H3,(H,20,24)(H,21,22,23)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant Erk2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 20: 7303-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.066
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50332081
PNG
(2-(4-methoxyphenyl)-N-(2-(1-methyl-1H-imidazol-4-y...)
Show SMILES COc1ccc(CC(=O)Nc2ccsc2-c2cn(C)cn2)cc1
Show InChI InChI=1S/C17H17N3O2S/c1-20-10-15(18-11-20)17-14(7-8-23-17)19-16(21)9-12-3-5-13(22-2)6-4-12/h3-8,10-11H,9H2,1-2H3,(H,19,21)