Found 35 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50325764
(4-(2'-(trifluoromethoxy)biphenyl-3-yl)thiazole-2-c...)Show SMILES NC(=O)c1nc(cs1)-c1cccc(c1)-c1ccccc1OC(F)(F)F Show InChI InChI=1S/C17H11F3N2O2S/c18-17(19,20)24-14-7-2-1-6-12(14)10-4-3-5-11(8-10)13-9-25-16(22-13)15(21)23/h1-9H,(H2,21,23) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 230 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human Nav1.7 by VIPR assay |
Bioorg Med Chem Lett 20: 7479-82 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.017 BindingDB Entry DOI: 10.7270/Q2MW2HDH |
More data for this Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50325762
(1-(2',4'-bis(trifluoromethyl)biphenyl-3-yl)-5-meth...)Show SMILES Cc1cc(nn1-c1cccc(c1)-c1ccc(cc1C(F)(F)F)C(F)(F)F)C(N)=O Show InChI InChI=1S/C19H13F6N3O/c1-10-7-16(17(26)29)27-28(10)13-4-2-3-11(8-13)14-6-5-12(18(20,21)22)9-15(14)19(23,24)25/h2-9H,1H3,(H2,26,29) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 340 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human Nav1.7 by VIPR assay |
Bioorg Med Chem Lett 20: 7479-82 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.017 BindingDB Entry DOI: 10.7270/Q2MW2HDH |
More data for this Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50332656
(CHEMBL1631089 | ethyl 3-carbamoyl-1-(2'-(trifluoro...)Show SMILES CCOC(=O)c1cc(nn1-c1cccc(c1)-c1ccccc1OC(F)(F)F)C(N)=O Show InChI InChI=1S/C20H16F3N3O4/c1-2-29-19(28)16-11-15(18(24)27)25-26(16)13-7-5-6-12(10-13)14-8-3-4-9-17(14)30-20(21,22)23/h3-11H,2H2,1H3,(H2,24,27) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human Nav1.7 by VIPR assay |
Bioorg Med Chem Lett 20: 7479-82 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.017 BindingDB Entry DOI: 10.7270/Q2MW2HDH |
More data for this Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50332657
(CHEMBL1631090 | N5-ethyl-1-(2'-(trifluoromethoxy)b...)Show SMILES CCNC(=O)c1cc(nn1-c1cccc(c1)-c1ccccc1OC(F)(F)F)C(N)=O Show InChI InChI=1S/C20H17F3N4O3/c1-2-25-19(29)16-11-15(18(24)28)26-27(16)13-7-5-6-12(10-13)14-8-3-4-9-17(14)30-20(21,22)23/h3-11H,2H2,1H3,(H2,24,28)(H,25,29) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human Nav1.7 by VIPR assay |
Bioorg Med Chem Lett 20: 7479-82 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.017 BindingDB Entry DOI: 10.7270/Q2MW2HDH |
More data for this Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50332649
(1-(5'-fluoro-2'-(2,2,3,3,3-pentafluoropropoxy)biph...)Show SMILES NC(=O)c1cc(C(N)=O)n(n1)-c1cccc(c1)-c1cc(F)ccc1OCC(F)(F)C(F)(F)F Show InChI InChI=1S/C20H14F6N4O3/c21-11-4-5-16(33-9-19(22,23)20(24,25)26)13(7-11)10-2-1-3-12(6-10)30-15(18(28)32)8-14(29-30)17(27)31/h1-8H,9H2,(H2,27,31)(H2,28,32) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human Nav1.7 by VIPR assay |
Bioorg Med Chem Lett 20: 7479-82 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.017 BindingDB Entry DOI: 10.7270/Q2MW2HDH |
More data for this Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50332652
(1-(2'-(trifluoromethoxy)biphenyl-3-yl)-1H-pyrazole...)Show SMILES NC(=O)c1cn(nc1C(N)=O)-c1cccc(c1)-c1ccccc1OC(F)(F)F Show InChI InChI=1S/C18H13F3N4O3/c19-18(20,21)28-14-7-2-1-6-12(14)10-4-3-5-11(8-10)25-9-13(16(22)26)15(24-25)17(23)27/h1-9H,(H2,22,26)(H2,23,27) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 49 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human Nav1.7 by VIPR assay |
Bioorg Med Chem Lett 20: 7479-82 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.017 BindingDB Entry DOI: 10.7270/Q2MW2HDH |
More data for this Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50332650
(1-(2'-(2,2,3,3,3-pentafluoropropoxy)-3'-(trifluoro...)Show SMILES NC(=O)c1cc(C(N)=O)n(n1)-c1cccc(c1)-c1cccc(OC(F)(F)F)c1OCC(F)(F)C(F)(F)F Show InChI InChI=1S/C21H14F8N4O4/c22-19(23,20(24,25)26)9-36-16-12(5-2-6-15(16)37-21(27,28)29)10-3-1-4-11(7-10)33-14(18(31)35)8-13(32-33)17(30)34/h1-8H,9H2,(H2,30,34)(H2,31,35) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 64 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human Nav1.7 by VIPR assay |
Bioorg Med Chem Lett 20: 7479-82 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.017 BindingDB Entry DOI: 10.7270/Q2MW2HDH |
More data for this Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50332662
(1-(4'-fluoro-2'-(2,2,3,3,3-pentafluoropropoxy)biph...)Show SMILES NC(=O)c1cc(C(N)=O)n(n1)-c1cccc(c1)-c1ccc(F)cc1OCC(F)(F)C(F)(F)F Show InChI InChI=1S/C20H14F6N4O3/c21-11-4-5-13(16(7-11)33-9-19(22,23)20(24,25)26)10-2-1-3-12(6-10)30-15(18(28)32)8-14(29-30)17(27)31/h1-8H,9H2,(H2,27,31)(H2,28,32) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 106 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human Nav1.7 by VIPR assay |
Bioorg Med Chem Lett 20: 7479-82 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.017 BindingDB Entry DOI: 10.7270/Q2MW2HDH |
More data for this Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50332647
(1-(2'-fluoro-6'-(trifluoromethoxy)biphenyl-3-yl)-1...)Show SMILES NC(=O)c1cc(C(N)=O)n(n1)-c1cccc(c1)-c1c(F)cccc1OC(F)(F)F Show InChI InChI=1S/C18H12F4N4O3/c19-11-5-2-6-14(29-18(20,21)22)15(11)9-3-1-4-10(7-9)26-13(17(24)28)8-12(25-26)16(23)27/h1-8H,(H2,23,27)(H2,24,28) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 106 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human Nav1.7 by VIPR assay |
Bioorg Med Chem Lett 20: 7479-82 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.017 BindingDB Entry DOI: 10.7270/Q2MW2HDH |
More data for this Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50332654
(1-(2'-(trifluoromethoxy)biphenyl-3-yl)-1H-pyrazole...)Show SMILES NC(=O)c1nn(c(C(N)=O)c1C(N)=O)-c1cccc(c1)-c1ccccc1OC(F)(F)F Show InChI InChI=1S/C19H14F3N5O4/c20-19(21,22)31-12-7-2-1-6-11(12)9-4-3-5-10(8-9)27-15(18(25)30)13(16(23)28)14(26-27)17(24)29/h1-8H,(H2,23,28)(H2,24,29)(H2,25,30) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 115 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human Nav1.7 by VIPR assay |
Bioorg Med Chem Lett 20: 7479-82 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.017 BindingDB Entry DOI: 10.7270/Q2MW2HDH |
More data for this Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50332655
(1-(2'-(trifluoromethoxy)biphenyl-3-yl)-1H-pyrazole...)Show SMILES NC(=O)c1cc(C(N)=O)n(n1)-c1cccc(c1)-c1ccccc1OC(F)(F)F Show InChI InChI=1S/C18H13F3N4O3/c19-18(20,21)28-15-7-2-1-6-12(15)10-4-3-5-11(8-10)25-14(17(23)27)9-13(24-25)16(22)26/h1-9H,(H2,22,26)(H2,23,27) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 132 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human Nav1.7 by VIPR assay |
Bioorg Med Chem Lett 20: 7479-82 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.017 BindingDB Entry DOI: 10.7270/Q2MW2HDH |
More data for this Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50332651
(1-(2'-(2,2,3,3,3-pentafluoropropoxy)-3'-(trifluoro...)Show SMILES NC(=O)c1cc(C(N)=O)n(n1)-c1cccc(c1)-c1cccc(c1OCC(F)(F)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C21H14F8N4O3/c22-19(23,21(27,28)29)9-36-16-12(5-2-6-13(16)20(24,25)26)10-3-1-4-11(7-10)33-15(18(31)35)8-14(32-33)17(30)34/h1-8H,9H2,(H2,30,34)(H2,31,35) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 147 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human Nav1.7 by VIPR assay |
Bioorg Med Chem Lett 20: 7479-82 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.017 BindingDB Entry DOI: 10.7270/Q2MW2HDH |
More data for this Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50332649
(1-(5'-fluoro-2'-(2,2,3,3,3-pentafluoropropoxy)biph...)Show SMILES NC(=O)c1cc(C(N)=O)n(n1)-c1cccc(c1)-c1cc(F)ccc1OCC(F)(F)C(F)(F)F Show InChI InChI=1S/C20H14F6N4O3/c21-11-4-5-16(33-9-19(22,23)20(24,25)26)13(7-11)10-2-1-3-12(6-10)30-15(18(28)32)8-14(29-30)17(27)31/h1-8H,9H2,(H2,27,31)(H2,28,32) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 149 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human Nav1.8 by VIPR assay |
Bioorg Med Chem Lett 20: 7479-82 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.017 BindingDB Entry DOI: 10.7270/Q2MW2HDH |
More data for this Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50332659
(1-(2'-(trifluoromethyl)biphenyl-3-yl)-1H-pyrazole-...)Show SMILES NC(=O)c1cc(C(N)=O)n(n1)-c1cccc(c1)-c1ccccc1C(F)(F)F Show InChI InChI=1S/C18H13F3N4O2/c19-18(20,21)13-7-2-1-6-12(13)10-4-3-5-11(8-10)25-15(17(23)27)9-14(24-25)16(22)26/h1-9H,(H2,22,26)(H2,23,27) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 155 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human Nav1.7 by VIPR assay |
Bioorg Med Chem Lett 20: 7479-82 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.017 BindingDB Entry DOI: 10.7270/Q2MW2HDH |
More data for this Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50332653
(5-methyl-1-(2'-(trifluoromethoxy)biphenyl-3-yl)-1H...)Show SMILES Cc1c(C(N)=O)c(nn1-c1cccc(c1)-c1ccccc1OC(F)(F)F)C(N)=O Show InChI InChI=1S/C19H15F3N4O3/c1-10-15(17(23)27)16(18(24)28)25-26(10)12-6-4-5-11(9-12)13-7-2-3-8-14(13)29-19(20,21)22/h2-9H,1H3,(H2,23,27)(H2,24,28) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 185 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human Nav1.7 by VIPR assay |
Bioorg Med Chem Lett 20: 7479-82 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.017 BindingDB Entry DOI: 10.7270/Q2MW2HDH |
More data for this Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50332658
(1-(2',3'-dichlorobiphenyl-3-yl)-1H-pyrazole-3,5-di...)Show SMILES NC(=O)c1cc(C(N)=O)n(n1)-c1cccc(c1)-c1cccc(Cl)c1Cl Show InChI InChI=1S/C17H12Cl2N4O2/c18-12-6-2-5-11(15(12)19)9-3-1-4-10(7-9)23-14(17(21)25)8-13(22-23)16(20)24/h1-8H,(H2,20,24)(H2,21,25) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 195 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human Nav1.7 by VIPR assay |
Bioorg Med Chem Lett 20: 7479-82 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.017 BindingDB Entry DOI: 10.7270/Q2MW2HDH |
More data for this Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50332650
(1-(2'-(2,2,3,3,3-pentafluoropropoxy)-3'-(trifluoro...)Show SMILES NC(=O)c1cc(C(N)=O)n(n1)-c1cccc(c1)-c1cccc(OC(F)(F)F)c1OCC(F)(F)C(F)(F)F Show InChI InChI=1S/C21H14F8N4O4/c22-19(23,20(24,25)26)9-36-16-12(5-2-6-15(16)37-21(27,28)29)10-3-1-4-11(7-10)33-14(18(31)35)8-13(32-33)17(30)34/h1-8H,9H2,(H2,30,34)(H2,31,35) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 203 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human Nav1.8 by VIPR assay |
Bioorg Med Chem Lett 20: 7479-82 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.017 BindingDB Entry DOI: 10.7270/Q2MW2HDH |
More data for this Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50325771
(5-methyl-1-(2'-(trifluoromethoxy)biphenyl-3-yl)-1H...)Show SMILES Cc1cc(nn1-c1cccc(c1)-c1ccccc1OC(F)(F)F)C(N)=O Show InChI InChI=1S/C18H14F3N3O2/c1-11-9-15(17(22)25)23-24(11)13-6-4-5-12(10-13)14-7-2-3-8-16(14)26-18(19,20)21/h2-10H,1H3,(H2,22,25) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 224 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human Nav1.7 by VIPR assay |
Bioorg Med Chem Lett 20: 7479-82 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.017 BindingDB Entry DOI: 10.7270/Q2MW2HDH |
More data for this Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50332646
(1-(2'-fluoro-3'-(trifluoromethoxy)biphenyl-3-yl)-1...)Show SMILES NC(=O)c1cc(C(N)=O)n(n1)-c1cccc(c1)-c1cccc(OC(F)(F)F)c1F Show InChI InChI=1S/C18H12F4N4O3/c19-15-11(5-2-6-14(15)29-18(20,21)22)9-3-1-4-10(7-9)26-13(17(24)28)8-12(25-26)16(23)27/h1-8H,(H2,23,27)(H2,24,28) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 282 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human Nav1.7 by VIPR assay |
Bioorg Med Chem Lett 20: 7479-82 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.017 BindingDB Entry DOI: 10.7270/Q2MW2HDH |
More data for this Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50332651
(1-(2'-(2,2,3,3,3-pentafluoropropoxy)-3'-(trifluoro...)Show SMILES NC(=O)c1cc(C(N)=O)n(n1)-c1cccc(c1)-c1cccc(c1OCC(F)(F)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C21H14F8N4O3/c22-19(23,21(27,28)29)9-36-16-12(5-2-6-13(16)20(24,25)26)10-3-1-4-11(7-10)33-15(18(31)35)8-14(32-33)17(30)34/h1-8H,9H2,(H2,30,34)(H2,31,35) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 299 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human Nav1.8 by VIPR assay |
Bioorg Med Chem Lett 20: 7479-82 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.017 BindingDB Entry DOI: 10.7270/Q2MW2HDH |
More data for this Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50332648
(1-(2'-(trifluoromethoxy)-5'-(trifluoromethyl)biphe...)Show SMILES NC(=O)c1cc(C(N)=O)n(n1)-c1cccc(c1)-c1cc(ccc1OC(F)(F)F)C(F)(F)F Show InChI InChI=1S/C19H12F6N4O3/c20-18(21,22)10-4-5-15(32-19(23,24)25)12(7-10)9-2-1-3-11(6-9)29-14(17(27)31)8-13(28-29)16(26)30/h1-8H,(H2,26,30)(H2,27,31) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 325 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human Nav1.7 by VIPR assay |
Bioorg Med Chem Lett 20: 7479-82 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.017 BindingDB Entry DOI: 10.7270/Q2MW2HDH |
More data for this Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50332661
(1-(6-fluoro-2'-(trifluoromethoxy)biphenyl-3-yl)-1H...)Show SMILES NC(=O)c1cc(C(N)=O)n(n1)-c1ccc(F)c(c1)-c1ccccc1OC(F)(F)F Show InChI InChI=1S/C18H12F4N4O3/c19-12-6-5-9(26-14(17(24)28)8-13(25-26)16(23)27)7-11(12)10-3-1-2-4-15(10)29-18(20,21)22/h1-8H,(H2,23,27)(H2,24,28) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 477 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human Nav1.7 by VIPR assay |
Bioorg Med Chem Lett 20: 7479-82 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.017 BindingDB Entry DOI: 10.7270/Q2MW2HDH |
More data for this Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50332655
(1-(2'-(trifluoromethoxy)biphenyl-3-yl)-1H-pyrazole...)Show SMILES NC(=O)c1cc(C(N)=O)n(n1)-c1cccc(c1)-c1ccccc1OC(F)(F)F Show InChI InChI=1S/C18H13F3N4O3/c19-18(20,21)28-15-7-2-1-6-12(15)10-4-3-5-11(8-10)25-14(17(23)27)9-13(24-25)16(22)26/h1-9H,(H2,22,26)(H2,23,27) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 554 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human Nav1.8 by VIPR assay |
Bioorg Med Chem Lett 20: 7479-82 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.017 BindingDB Entry DOI: 10.7270/Q2MW2HDH |
More data for this Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50332660
(1-(2',6'-bis(trifluoromethyl)biphenyl-3-yl)-1H-pyr...)Show SMILES NC(=O)c1cc(C(N)=O)n(n1)-c1cccc(c1)-c1c(cccc1C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C19H12F6N4O2/c20-18(21,22)11-5-2-6-12(19(23,24)25)15(11)9-3-1-4-10(7-9)29-14(17(27)31)8-13(28-29)16(26)30/h1-8H,(H2,26,30)(H2,27,31) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 715 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human Nav1.7 by VIPR assay |
Bioorg Med Chem Lett 20: 7479-82 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.017 BindingDB Entry DOI: 10.7270/Q2MW2HDH |
More data for this Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50332647
(1-(2'-fluoro-6'-(trifluoromethoxy)biphenyl-3-yl)-1...)Show SMILES NC(=O)c1cc(C(N)=O)n(n1)-c1cccc(c1)-c1c(F)cccc1OC(F)(F)F Show InChI InChI=1S/C18H12F4N4O3/c19-11-5-2-6-14(29-18(20,21)22)15(11)9-3-1-4-10(7-9)26-13(17(24)28)8-12(25-26)16(23)27/h1-8H,(H2,23,27)(H2,24,28) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 802 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human Nav1.8 by VIPR assay |
Bioorg Med Chem Lett 20: 7479-82 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.017 BindingDB Entry DOI: 10.7270/Q2MW2HDH |
More data for this Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50332645
(1-(2',5'-bis(trifluoromethyl)biphenyl-3-yl)-1H-pyr...)Show SMILES NC(=O)c1cc(C(N)=O)n(n1)-c1cccc(c1)-c1cc(ccc1C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C19H12F6N4O2/c20-18(21,22)10-4-5-13(19(23,24)25)12(7-10)9-2-1-3-11(6-9)29-15(17(27)31)8-14(28-29)16(26)30/h1-8H,(H2,26,30)(H2,27,31) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 810 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human Nav1.7 by VIPR assay |
Bioorg Med Chem Lett 20: 7479-82 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.017 BindingDB Entry DOI: 10.7270/Q2MW2HDH |
More data for this Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50332659
(1-(2'-(trifluoromethyl)biphenyl-3-yl)-1H-pyrazole-...)Show SMILES NC(=O)c1cc(C(N)=O)n(n1)-c1cccc(c1)-c1ccccc1C(F)(F)F Show InChI InChI=1S/C18H13F3N4O2/c19-18(20,21)13-7-2-1-6-12(13)10-4-3-5-11(8-10)25-15(17(23)27)9-14(24-25)16(22)26/h1-9H,(H2,22,26)(H2,23,27) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 915 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human Nav1.8 by VIPR assay |
Bioorg Med Chem Lett 20: 7479-82 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.017 BindingDB Entry DOI: 10.7270/Q2MW2HDH |
More data for this Ligand-Target Pair | |
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human)) | BDBM50332645
(1-(2',5'-bis(trifluoromethyl)biphenyl-3-yl)-1H-pyr...)Show SMILES NC(=O)c1cc(C(N)=O)n(n1)-c1cccc(c1)-c1cc(ccc1C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C19H12F6N4O2/c20-18(21,22)10-4-5-13(19(23,24)25)12(7-10)9-2-1-3-11(6-9)29-15(17(27)31)8-14(28-29)16(26)30/h1-8H,(H2,26,30)(H2,27,31) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.32E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of Nav1.5 by VIPR assay |
Bioorg Med Chem Lett 20: 7479-82 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.017 BindingDB Entry DOI: 10.7270/Q2MW2HDH |
More data for this Ligand-Target Pair | |
Cytochrome P450 2C9
(Homo sapiens (Human)) | BDBM50332645
(1-(2',5'-bis(trifluoromethyl)biphenyl-3-yl)-1H-pyr...)Show SMILES NC(=O)c1cc(C(N)=O)n(n1)-c1cccc(c1)-c1cc(ccc1C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C19H12F6N4O2/c20-18(21,22)10-4-5-13(19(23,24)25)12(7-10)9-2-1-3-11(6-9)29-15(17(27)31)8-14(28-29)16(26)30/h1-8H,(H2,26,30)(H2,27,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.03E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of CYP2C9 |
Bioorg Med Chem Lett 20: 7479-82 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.017 BindingDB Entry DOI: 10.7270/Q2MW2HDH |
More data for this Ligand-Target Pair | |
Nuclear receptor subfamily 1 group I member 2
(Homo sapiens (Human)) | BDBM50332645
(1-(2',5'-bis(trifluoromethyl)biphenyl-3-yl)-1H-pyr...)Show SMILES NC(=O)c1cc(C(N)=O)n(n1)-c1cccc(c1)-c1cc(ccc1C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C19H12F6N4O2/c20-18(21,22)10-4-5-13(19(23,24)25)12(7-10)9-2-1-3-11(6-9)29-15(17(27)31)8-14(28-29)16(26)30/h1-8H,(H2,26,30)(H2,27,31) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Induction of PXR |
Bioorg Med Chem Lett 20: 7479-82 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.017 BindingDB Entry DOI: 10.7270/Q2MW2HDH |
More data for this Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM50332645
(1-(2',5'-bis(trifluoromethyl)biphenyl-3-yl)-1H-pyr...)Show SMILES NC(=O)c1cc(C(N)=O)n(n1)-c1cccc(c1)-c1cc(ccc1C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C19H12F6N4O2/c20-18(21,22)10-4-5-13(19(23,24)25)12(7-10)9-2-1-3-11(6-9)29-15(17(27)31)8-14(28-29)16(26)30/h1-8H,(H2,26,30)(H2,27,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of CYP3A4 |
Bioorg Med Chem Lett 20: 7479-82 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.017 BindingDB Entry DOI: 10.7270/Q2MW2HDH |
More data for this Ligand-Target Pair | |
Cytochrome P450 2D6
(Homo sapiens (Human)) | BDBM50332645
(1-(2',5'-bis(trifluoromethyl)biphenyl-3-yl)-1H-pyr...)Show SMILES NC(=O)c1cc(C(N)=O)n(n1)-c1cccc(c1)-c1cc(ccc1C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C19H12F6N4O2/c20-18(21,22)10-4-5-13(19(23,24)25)12(7-10)9-2-1-3-11(6-9)29-15(17(27)31)8-14(28-29)16(26)30/h1-8H,(H2,26,30)(H2,27,31) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of CYP2D6 |
Bioorg Med Chem Lett 20: 7479-82 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.017 BindingDB Entry DOI: 10.7270/Q2MW2HDH |
More data for this Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50332648
(1-(2'-(trifluoromethoxy)-5'-(trifluoromethyl)biphe...)Show SMILES NC(=O)c1cc(C(N)=O)n(n1)-c1cccc(c1)-c1cc(ccc1OC(F)(F)F)C(F)(F)F Show InChI InChI=1S/C19H12F6N4O3/c20-18(21,22)10-4-5-15(32-19(23,24)25)12(7-10)9-2-1-3-11(6-9)29-14(17(27)31)8-13(28-29)16(26)30/h1-8H,(H2,26,30)(H2,27,31) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.18E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human Nav1.8 by VIPR assay |
Bioorg Med Chem Lett 20: 7479-82 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.017 BindingDB Entry DOI: 10.7270/Q2MW2HDH |
More data for this Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50332646
(1-(2'-fluoro-3'-(trifluoromethoxy)biphenyl-3-yl)-1...)Show SMILES NC(=O)c1cc(C(N)=O)n(n1)-c1cccc(c1)-c1cccc(OC(F)(F)F)c1F Show InChI InChI=1S/C18H12F4N4O3/c19-15-11(5-2-6-14(15)29-18(20,21)22)9-3-1-4-10(7-9)26-13(17(24)28)8-12(25-26)16(23)27/h1-8H,(H2,23,27)(H2,24,28) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.51E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human Nav1.8 by VIPR assay |
Bioorg Med Chem Lett 20: 7479-82 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.017 BindingDB Entry DOI: 10.7270/Q2MW2HDH |
More data for this Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50332645
(1-(2',5'-bis(trifluoromethyl)biphenyl-3-yl)-1H-pyr...)Show SMILES NC(=O)c1cc(C(N)=O)n(n1)-c1cccc(c1)-c1cc(ccc1C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C19H12F6N4O2/c20-18(21,22)10-4-5-13(19(23,24)25)12(7-10)9-2-1-3-11(6-9)29-15(17(27)31)8-14(28-29)16(26)30/h1-8H,(H2,26,30)(H2,27,31) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human Nav1.8 by VIPR assay |
Bioorg Med Chem Lett 20: 7479-82 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.017 BindingDB Entry DOI: 10.7270/Q2MW2HDH |
More data for this Ligand-Target Pair | |