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PubMed code 21185187

Compile data set for download or QSAR
Found 42 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))		BDBM50333455
PNG
((2S,3S,4S,5S)-2-butyl-5-(hydroxymethyl)pyrrolidine...)
Show SMILES CCCC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C9H19NO3/c1-2-3-4-6-8(12)9(13)7(5-11)10-6/h6-13H,2-5H2,1H3/t6-,7-,8-,9-/m0/s1
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n/an/a 32n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine sucrase after 30 mins

Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))		BDBM50333457
PNG
((2S,3S,4S,5S)-2-hexyl-5-(hydroxymethyl)pyrrolidine...)
Show SMILES CCCCCC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C11H23NO3/c1-2-3-4-5-6-8-10(14)11(15)9(7-13)12-8/h8-15H,2-7H2,1H3/t8-,9-,10-,11-/m0/s1
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n/an/a 110n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine sucrase after 30 mins

Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
Lysosomal alpha-glucosidase


(Rattus norvegicus)		BDBM50333465
PNG
((2R,3R,4R,5R,6R)-5-((2R,3R,4R,5S,6R)-5-((2R,3R,4S,...)
Show SMILES C[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@H](O[C@@H]3[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O |r,t:37|
Show InChI InChI=1S/C25H43NO18/c1-6-11(26-8-2-7(3-27)12(30)15(33)13(8)31)14(32)19(37)24(40-6)43-22-10(5-29)42-25(20(38)17(22)35)44-21-9(4-28)41-23(39)18(36)16(21)34/h2,6,8-39H,3-5H2,1H3/t6-,8+,9-,10-,11-,12-,13+,14+,15+,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-/m1/s1
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Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine maltase after 30 mins

Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
Lysosomal alpha-glucosidase


(Rattus norvegicus)		BDBM50263044
PNG
(CHEMBL476960 | Voglibose)
Show SMILES OCC(CO)N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C10H21NO7/c12-2-5(3-13)11-6-1-10(18,4-14)9(17)8(16)7(6)15/h5-9,11-18H,1-4H2/t6-,7-,8+,9-,10-/m0/s1
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n/an/a 180n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine maltase after 30 mins

Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))		BDBM50333456
PNG
((2S,3S,4S,5S)-2-(hydroxymethyl)-5-pentylpyrrolidin...)
Show SMILES CCCCC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C10H21NO3/c1-2-3-4-5-7-9(13)10(14)8(6-12)11-7/h7-14H,2-6H2,1H3/t7-,8-,9-,10-/m0/s1
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Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine sucrase after 30 mins

Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
Lysosomal alpha-glucosidase


(Rattus norvegicus)		BDBM50333455
PNG
((2S,3S,4S,5S)-2-butyl-5-(hydroxymethyl)pyrrolidine...)
Show SMILES CCCC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C9H19NO3/c1-2-3-4-6-8(12)9(13)7(5-11)10-6/h6-13H,2-5H2,1H3/t6-,7-,8-,9-/m0/s1
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Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine maltase after 30 mins

Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))		BDBM50333458
PNG
((2S,3S,4S,5S)-2-heptyl-5-(hydroxymethyl)pyrrolidin...)
Show SMILES CCCCCCC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C12H25NO3/c1-2-3-4-5-6-7-9-11(15)12(16)10(8-14)13-9/h9-16H,2-8H2,1H3/t9-,10-,11-,12-/m0/s1
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n/an/a 240n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine sucrase after 30 mins

Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))		BDBM50333454
PNG
((2S,3S,4S,5S)-2-(hydroxymethyl)-5-propylpyrrolidin...)
Show SMILES CCC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C8H17NO3/c1-2-3-5-7(11)8(12)6(4-10)9-5/h5-12H,2-4H2,1H3/t5-,6-,7-,8-/m0/s1
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Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine sucrase after 30 mins

Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
Lysosomal alpha-glucosidase


(Rattus norvegicus)		BDBM50333459
PNG
((2S,3S,4S,5S)-2-(hydroxymethyl)-5-octylpyrrolidine...)
Show SMILES CCCCCCCC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C13H27NO3/c1-2-3-4-5-6-7-8-10-12(16)13(17)11(9-15)14-10/h10-17H,2-9H2,1H3/t10-,11-,12-,13-/m0/s1
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Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine maltase after 30 mins

Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))		BDBM50263044
PNG
(CHEMBL476960 | Voglibose)
Show SMILES OCC(CO)N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C10H21NO7/c12-2-5(3-13)11-6-1-10(18,4-14)9(17)8(16)7(6)15/h5-9,11-18H,1-4H2/t6-,7-,8+,9-,10-/m0/s1
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Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine sucrase after 30 mins

Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
Lysosomal alpha-glucosidase


(Rattus norvegicus)		BDBM50333458
PNG
((2S,3S,4S,5S)-2-heptyl-5-(hydroxymethyl)pyrrolidin...)
Show SMILES CCCCCCC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C12H25NO3/c1-2-3-4-5-6-7-9-11(15)12(16)10(8-14)13-9/h9-16H,2-8H2,1H3/t9-,10-,11-,12-/m0/s1
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n/an/a 380n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine maltase after 30 mins

Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))		BDBM50333459
PNG
((2S,3S,4S,5S)-2-(hydroxymethyl)-5-octylpyrrolidine...)
Show SMILES CCCCCCCC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C13H27NO3/c1-2-3-4-5-6-7-8-10-12(16)13(17)11(9-15)14-10/h10-17H,2-9H2,1H3/t10-,11-,12-,13-/m0/s1
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Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine sucrase after 30 mins

Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
Lysosomal alpha-glucosidase


(Rattus norvegicus)		BDBM50333457
PNG
((2S,3S,4S,5S)-2-hexyl-5-(hydroxymethyl)pyrrolidine...)
Show SMILES CCCCCC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C11H23NO3/c1-2-3-4-5-6-8-10(14)11(15)9(7-13)12-8/h8-15H,2-7H2,1H3/t8-,9-,10-,11-/m0/s1
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Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine maltase after 30 mins

Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
Lysosomal alpha-glucosidase


(Rattus norvegicus)		BDBM50242271
PNG
((2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl)...)
Show SMILES OCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO |r|
Show InChI InChI=1S/C8H17NO5/c10-2-1-9-3-6(12)8(14)7(13)5(9)4-11/h5-8,10-14H,1-4H2/t5-,6+,7-,8-/m1/s1
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Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine maltase after 30 mins

Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))		BDBM50333453
PNG
((2S,3S,4S,5S)-2-ethyl-5-(hydroxymethyl)pyrrolidine...)
Show SMILES CC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C7H15NO3/c1-2-4-6(10)7(11)5(3-9)8-4/h4-11H,2-3H2,1H3/t4-,5-,6-,7-/m0/s1
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n/an/a 680n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine sucrase after 30 mins

Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
Lysosomal alpha-glucosidase


(Rattus norvegicus)		BDBM50333456
PNG
((2S,3S,4S,5S)-2-(hydroxymethyl)-5-pentylpyrrolidin...)
Show SMILES CCCCC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C10H21NO3/c1-2-3-4-5-7-9(13)10(14)8(6-12)11-7/h7-14H,2-6H2,1H3/t7-,8-,9-,10-/m0/s1
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Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine maltase after 30 mins

Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
Lysosomal alpha-glucosidase


(Rattus norvegicus)		BDBM50333461
PNG
((2S,3S,4S,5S)-2-(hydroxymethyl)-5-nonylpyrrolidine...)
Show SMILES CCCCCCCCC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C14H29NO3/c1-2-3-4-5-6-7-8-9-11-13(17)14(18)12(10-16)15-11/h11-18H,2-10H2,1H3/t11-,12-,13-,14-/m0/s1
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n/an/a 840n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine maltase after 30 mins

Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))		BDBM50242271
PNG
((2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl)...)
Show SMILES OCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO |r|
Show InChI InChI=1S/C8H17NO5/c10-2-1-9-3-6(12)8(14)7(13)5(9)4-11/h5-8,10-14H,1-4H2/t5-,6+,7-,8-/m1/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine sucrase after 30 mins

Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
Lysosomal alpha-glucosidase


(Rattus norvegicus)		BDBM50333462
PNG
((2S,3S,4S,5S)-2-decyl-5-(hydroxymethyl)pyrrolidine...)
Show SMILES CCCCCCCCCC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C15H31NO3/c1-2-3-4-5-6-7-8-9-10-12-14(18)15(19)13(11-17)16-12/h12-19H,2-11H2,1H3/t12-,13-,14-,15-/m0/s1
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n/an/a 1.20E+3n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine maltase after 30 mins

Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))		BDBM50333461
PNG
((2S,3S,4S,5S)-2-(hydroxymethyl)-5-nonylpyrrolidine...)
Show SMILES CCCCCCCCC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C14H29NO3/c1-2-3-4-5-6-7-8-9-11-13(17)14(18)12(10-16)15-11/h11-18H,2-10H2,1H3/t11-,12-,13-,14-/m0/s1
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n/an/a 1.40E+3n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine sucrase after 30 mins

Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))		BDBM50333462
PNG
((2S,3S,4S,5S)-2-decyl-5-(hydroxymethyl)pyrrolidine...)
Show SMILES CCCCCCCCCC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C15H31NO3/c1-2-3-4-5-6-7-8-9-10-12-14(18)15(19)13(11-17)16-12/h12-19H,2-11H2,1H3/t12-,13-,14-,15-/m0/s1
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n/an/a 1.70E+3n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine sucrase after 30 mins

Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
Lysosomal alpha-glucosidase


(Rattus norvegicus)		BDBM50333454
PNG
((2S,3S,4S,5S)-2-(hydroxymethyl)-5-propylpyrrolidin...)
Show SMILES CCC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C8H17NO3/c1-2-3-5-7(11)8(12)6(4-10)9-5/h5-12H,2-4H2,1H3/t5-,6-,7-,8-/m0/s1
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n/an/a 1.70E+3n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine maltase after 30 mins

Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
Lysosomal alpha-glucosidase


(Rattus norvegicus)		BDBM50333453
PNG
((2S,3S,4S,5S)-2-ethyl-5-(hydroxymethyl)pyrrolidine...)
Show SMILES CC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C7H15NO3/c1-2-4-6(10)7(11)5(3-9)8-4/h4-11H,2-3H2,1H3/t4-,5-,6-,7-/m0/s1
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n/an/a 2.60E+3n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine maltase after 30 mins

Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))		BDBM50333465
PNG
((2R,3R,4R,5R,6R)-5-((2R,3R,4R,5S,6R)-5-((2R,3R,4S,...)
Show SMILES C[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@H](O[C@@H]3[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O |r,t:37|
Show InChI InChI=1S/C25H43NO18/c1-6-11(26-8-2-7(3-27)12(30)15(33)13(8)31)14(32)19(37)24(40-6)43-22-10(5-29)42-25(20(38)17(22)35)44-21-9(4-28)41-23(39)18(36)16(21)34/h2,6,8-39H,3-5H2,1H3/t6-,8+,9-,10-,11-,12-,13+,14+,15+,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-/m1/s1
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n/an/a 2.90E+3n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine sucrase after 30 mins

Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
Lysosomal alpha-glucosidase


(Rattus norvegicus)		BDBM50333463
PNG
((2S,3S,4S,5S)-2-(hydroxymethyl)-5-undecylpyrrolidi...)
Show SMILES CCCCCCCCCCC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C16H33NO3/c1-2-3-4-5-6-7-8-9-10-11-13-15(19)16(20)14(12-18)17-13/h13-20H,2-12H2,1H3/t13-,14-,15-,16-/m0/s1
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n/an/a 3.90E+3n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine maltase after 30 mins

Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))		BDBM50333455
PNG
((2S,3S,4S,5S)-2-butyl-5-(hydroxymethyl)pyrrolidine...)
Show SMILES CCCC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C9H19NO3/c1-2-3-4-6-8(12)9(13)7(5-11)10-6/h6-13H,2-5H2,1H3/t6-,7-,8-,9-/m0/s1
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n/an/a 4.70E+3n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine isomaltase after 30 mins

Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))		BDBM50263044
PNG
(CHEMBL476960 | Voglibose)
Show SMILES OCC(CO)N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C10H21NO7/c12-2-5(3-13)11-6-1-10(18,4-14)9(17)8(16)7(6)15/h5-9,11-18H,1-4H2/t6-,7-,8+,9-,10-/m0/s1
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n/an/a 5.20E+3n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine isomaltase after 30 mins

Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))		BDBM50333464
PNG
((2S,3S,4S,5S)-1,2-dibutyl-5-(hydroxymethyl)pyrroli...)
Show SMILES CCCC[C@H]1[C@H](O)[C@@H](O)[C@H](CO)N1CCCC |r|
Show InChI InChI=1S/C13H27NO3/c1-3-5-7-10-12(16)13(17)11(9-15)14(10)8-6-4-2/h10-13,15-17H,3-9H2,1-2H3/t10-,11-,12-,13-/m0/s1
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n/an/a 8.80E+3n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine sucrase after 30 mins

Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))		BDBM50333457
PNG
((2S,3S,4S,5S)-2-hexyl-5-(hydroxymethyl)pyrrolidine...)
Show SMILES CCCCCC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C11H23NO3/c1-2-3-4-5-6-8-10(14)11(15)9(7-13)12-8/h8-15H,2-7H2,1H3/t8-,9-,10-,11-/m0/s1
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n/an/a 1.10E+4n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine isomaltase after 30 mins

Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))		BDBM50333453
PNG
((2S,3S,4S,5S)-2-ethyl-5-(hydroxymethyl)pyrrolidine...)
Show SMILES CC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C7H15NO3/c1-2-4-6(10)7(11)5(3-9)8-4/h4-11H,2-3H2,1H3/t4-,5-,6-,7-/m0/s1
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n/an/a 1.10E+4n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine isomaltase after 30 mins

Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))		BDBM50333463
PNG
((2S,3S,4S,5S)-2-(hydroxymethyl)-5-undecylpyrrolidi...)
Show SMILES CCCCCCCCCCC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C16H33NO3/c1-2-3-4-5-6-7-8-9-10-11-13-15(19)16(20)14(12-18)17-13/h13-20H,2-12H2,1H3/t13-,14-,15-,16-/m0/s1
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n/an/a 1.30E+4n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine sucrase after 30 mins

Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))		BDBM50333458
PNG
((2S,3S,4S,5S)-2-heptyl-5-(hydroxymethyl)pyrrolidin...)
Show SMILES CCCCCCC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C12H25NO3/c1-2-3-4-5-6-7-9-11(15)12(16)10(8-14)13-9/h9-16H,2-8H2,1H3/t9-,10-,11-,12-/m0/s1
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n/an/a 1.60E+4n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine isomaltase after 30 mins

Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))		BDBM50333456
PNG
((2S,3S,4S,5S)-2-(hydroxymethyl)-5-pentylpyrrolidin...)
Show SMILES CCCCC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C10H21NO3/c1-2-3-4-5-7-9(13)10(14)8(6-12)11-7/h7-14H,2-6H2,1H3/t7-,8-,9-,10-/m0/s1
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n/an/a 1.80E+4n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine isomaltase after 30 mins

Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
Lysosomal alpha-glucosidase


(Rattus norvegicus)		BDBM50333464
PNG
((2S,3S,4S,5S)-1,2-dibutyl-5-(hydroxymethyl)pyrroli...)
Show SMILES CCCC[C@H]1[C@H](O)[C@@H](O)[C@H](CO)N1CCCC |r|
Show InChI InChI=1S/C13H27NO3/c1-3-5-7-10-12(16)13(17)11(9-15)14(10)8-6-4-2/h10-13,15-17H,3-9H2,1-2H3/t10-,11-,12-,13-/m0/s1
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n/an/a 2.50E+4n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine maltase after 30 mins

Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))		BDBM50242271
PNG
((2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl)...)
Show SMILES OCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO |r|
Show InChI InChI=1S/C8H17NO5/c10-2-1-9-3-6(12)8(14)7(13)5(9)4-11/h5-8,10-14H,1-4H2/t5-,6+,7-,8-/m1/s1
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n/an/a 3.90E+4n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine isomaltase after 30 mins

Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))		BDBM50333454
PNG
((2S,3S,4S,5S)-2-(hydroxymethyl)-5-propylpyrrolidin...)
Show SMILES CCC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C8H17NO3/c1-2-3-5-7(11)8(12)6(4-10)9-5/h5-12H,2-4H2,1H3/t5-,6-,7-,8-/m0/s1
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n/an/a 4.70E+4n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine isomaltase after 30 mins

Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))		BDBM50333459
PNG
((2S,3S,4S,5S)-2-(hydroxymethyl)-5-octylpyrrolidine...)
Show SMILES CCCCCCCC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C13H27NO3/c1-2-3-4-5-6-7-8-10-12(16)13(17)11(9-15)14-10/h10-17H,2-9H2,1H3/t10-,11-,12-,13-/m0/s1
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n/an/a 7.50E+4n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine isomaltase after 30 mins

Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))		BDBM50333461
PNG
((2S,3S,4S,5S)-2-(hydroxymethyl)-5-nonylpyrrolidine...)
Show SMILES CCCCCCCCC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C14H29NO3/c1-2-3-4-5-6-7-8-9-11-13(17)14(18)12(10-16)15-11/h11-18H,2-10H2,1H3/t11-,12-,13-,14-/m0/s1
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n/an/a 1.71E+5n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine isomaltase after 30 mins

Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))		BDBM50333466
PNG
((2R,3S,4S,5S)-2-butyl-5-(hydroxymethyl)pyrrolidine...)
Show SMILES CCCC[C@H]1N[C@@H](CO)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C9H19NO3/c1-2-3-4-6-8(12)9(13)7(5-11)10-6/h6-13H,2-5H2,1H3/t6-,7+,8+,9+/m1/s1
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n/an/a 3.92E+5n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine sucrase after 30 mins

Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
Lysosomal alpha-glucosidase


(Rattus norvegicus)		BDBM50333460
PNG
((2S,3S,4S,5R)-2-(hydroxymethyl)-5-octylpyrrolidine...)
Show SMILES CCCCCCCC[C@H]1N[C@@H](CO)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C13H27NO3/c1-2-3-4-5-6-7-8-10-12(16)13(17)11(9-15)14-10/h10-17H,2-9H2,1H3/t10-,11+,12+,13+/m1/s1
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n/an/a 5.00E+5n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine maltase after 30 mins

Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))		BDBM50333460
PNG
((2S,3S,4S,5R)-2-(hydroxymethyl)-5-octylpyrrolidine...)
Show SMILES CCCCCCCC[C@H]1N[C@@H](CO)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C13H27NO3/c1-2-3-4-5-6-7-8-10-12(16)13(17)11(9-15)14-10/h10-17H,2-9H2,1H3/t10-,11+,12+,13+/m1/s1
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n/an/a 5.90E+5n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine sucrase after 30 mins

Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))		BDBM50333462
PNG
((2S,3S,4S,5S)-2-decyl-5-(hydroxymethyl)pyrrolidine...)
Show SMILES CCCCCCCCCC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C15H31NO3/c1-2-3-4-5-6-7-8-9-10-12-14(18)15(19)13(11-17)16-12/h12-19H,2-11H2,1H3/t12-,13-,14-,15-/m0/s1
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n/an/a 6.06E+5n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine isomaltase after 30 mins

Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%