Found 66 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50333813
(3-(4-Morpholino-6-(pyridin-2-yl)pyrimidin-2-yl)phe...)Show InChI InChI=1S/C19H18N4O2/c24-15-5-3-4-14(12-15)19-21-17(16-6-1-2-7-20-16)13-18(22-19)23-8-10-25-11-9-23/h1-7,12-13,24H,8-11H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110gamma after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333813
(3-(4-Morpholino-6-(pyridin-2-yl)pyrimidin-2-yl)phe...)Show InChI InChI=1S/C19H18N4O2/c24-15-5-3-4-14(12-15)19-21-17(16-6-1-2-7-20-16)13-18(22-19)23-8-10-25-11-9-23/h1-7,12-13,24H,8-11H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50333813
(3-(4-Morpholino-6-(pyridin-2-yl)pyrimidin-2-yl)phe...)Show InChI InChI=1S/C19H18N4O2/c24-15-5-3-4-14(12-15)19-21-17(16-6-1-2-7-20-16)13-18(22-19)23-8-10-25-11-9-23/h1-7,12-13,24H,8-11H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110beta after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333821
(3-(2-Morpholino-6-(pyridin-2-ylmethoxy)pyrimidin-4...)Show InChI InChI=1S/C20H20N4O3/c25-17-6-3-4-15(12-17)18-13-19(27-14-16-5-1-2-7-21-16)23-20(22-18)24-8-10-26-11-9-24/h1-7,12-13,25H,8-11,14H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333815
(3-(4-Morpholino-6-(pyridin-4-yl)pyrimidin-2-yl)phe...)Show InChI InChI=1S/C19H18N4O2/c24-16-3-1-2-15(12-16)19-21-17(14-4-6-20-7-5-14)13-18(22-19)23-8-10-25-11-9-23/h1-7,12-13,24H,8-11H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333819
(3-(2-Morpholino-6-(2-(pyridin-4-yl)ethylamino)pyri...)Show SMILES Oc1cccc(c1)-c1cc(NCCc2ccncc2)nc(n1)N1CCOCC1 Show InChI InChI=1S/C21H23N5O2/c27-18-3-1-2-17(14-18)19-15-20(23-9-6-16-4-7-22-8-5-16)25-21(24-19)26-10-12-28-13-11-26/h1-5,7-8,14-15,27H,6,9-13H2,(H,23,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50333815
(3-(4-Morpholino-6-(pyridin-4-yl)pyrimidin-2-yl)phe...)Show InChI InChI=1S/C19H18N4O2/c24-16-3-1-2-15(12-16)19-21-17(14-4-6-20-7-5-14)13-18(22-19)23-8-10-25-11-9-23/h1-7,12-13,24H,8-11H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110gamma after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333820
(3-(6-Morpholino-2-(2-(pyridin-2-yl)ethylamino)pyri...)Show SMILES Oc1cccc(c1)-c1cc(nc(NCCc2ccccn2)n1)N1CCOCC1 Show InChI InChI=1S/C21H23N5O2/c27-18-6-3-4-16(14-18)19-15-20(26-10-12-28-13-11-26)25-21(24-19)23-9-7-17-5-1-2-8-22-17/h1-6,8,14-15,27H,7,9-13H2,(H,23,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50333815
(3-(4-Morpholino-6-(pyridin-4-yl)pyrimidin-2-yl)phe...)Show InChI InChI=1S/C19H18N4O2/c24-16-3-1-2-15(12-16)19-21-17(14-4-6-20-7-5-14)13-18(22-19)23-8-10-25-11-9-23/h1-7,12-13,24H,8-11H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110beta after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333828
(3-(4-(3,4-Dichlorophenyl)-6-morpholinopyrimidin-2-...)Show SMILES Oc1cccc(c1)-c1nc(cc(n1)-c1ccc(Cl)c(Cl)c1)N1CCOCC1 Show InChI InChI=1S/C20H17Cl2N3O2/c21-16-5-4-13(11-17(16)22)18-12-19(25-6-8-27-9-7-25)24-20(23-18)14-2-1-3-15(26)10-14/h1-5,10-12,26H,6-9H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333834
(3-(6-Morpholino-2-(2-(pyridin-4-yl)ethylamino)pyri...)Show SMILES Oc1cccc(c1)-c1cc(nc(NCCc2ccncc2)n1)N1CCOCC1 Show InChI InChI=1S/C21H23N5O2/c27-18-3-1-2-17(14-18)19-15-20(26-10-12-28-13-11-26)25-21(24-19)23-9-6-16-4-7-22-8-5-16/h1-5,7-8,14-15,27H,6,9-13H2,(H,23,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333817
(3-(2-Morpholino-6-(2-(pyridin-2-yl)ethylamino)pyri...)Show SMILES Oc1cccc(c1)-c1cc(NCCc2ccccn2)nc(n1)N1CCOCC1 Show InChI InChI=1S/C21H23N5O2/c27-18-6-3-4-16(14-18)19-15-20(23-9-7-17-5-1-2-8-22-17)25-21(24-19)26-10-12-28-13-11-26/h1-6,8,14-15,27H,7,9-13H2,(H,23,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333833
(3-(6-Morpholino-2-(2-(pyridin-3-yl)ethylamino)pyri...)Show SMILES Oc1cccc(c1)-c1cc(nc(NCCc2cccnc2)n1)N1CCOCC1 Show InChI InChI=1S/C21H23N5O2/c27-18-5-1-4-17(13-18)19-14-20(26-9-11-28-12-10-26)25-21(24-19)23-8-6-16-3-2-7-22-15-16/h1-5,7,13-15,27H,6,8-12H2,(H,23,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333818
(3-(2-Morpholino-6-(2-(pyridin-3-yl)ethylamino)pyri...)Show SMILES Oc1cccc(c1)-c1cc(NCCc2cccnc2)nc(n1)N1CCOCC1 Show InChI InChI=1S/C21H23N5O2/c27-18-5-1-4-17(13-18)19-14-20(23-8-6-16-3-2-7-22-15-16)25-21(24-19)26-9-11-28-12-10-26/h1-5,7,13-15,27H,6,8-12H2,(H,23,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333814
(3-(4-Morpholino-6-(pyridin-3-yl)pyrimidin-2-yl)phe...)Show InChI InChI=1S/C19H18N4O2/c24-16-5-1-3-14(11-16)19-21-17(15-4-2-6-20-13-15)12-18(22-19)23-7-9-25-10-8-23/h1-6,11-13,24H,7-10H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50333814
(3-(4-Morpholino-6-(pyridin-3-yl)pyrimidin-2-yl)phe...)Show InChI InChI=1S/C19H18N4O2/c24-16-5-1-3-14(11-16)19-21-17(15-4-2-6-20-13-15)12-18(22-19)23-7-9-25-10-8-23/h1-6,11-13,24H,7-10H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110gamma after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50333821
(3-(2-Morpholino-6-(pyridin-2-ylmethoxy)pyrimidin-4...)Show InChI InChI=1S/C20H20N4O3/c25-17-6-3-4-15(12-17)18-13-19(27-14-16-5-1-2-7-21-16)23-20(22-18)24-8-10-26-11-9-24/h1-7,12-13,25H,8-11,14H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110beta after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50333820
(3-(6-Morpholino-2-(2-(pyridin-2-yl)ethylamino)pyri...)Show SMILES Oc1cccc(c1)-c1cc(nc(NCCc2ccccn2)n1)N1CCOCC1 Show InChI InChI=1S/C21H23N5O2/c27-18-6-3-4-16(14-18)19-15-20(26-10-12-28-13-11-26)25-21(24-19)23-9-7-17-5-1-2-8-22-17/h1-6,8,14-15,27H,7,9-13H2,(H,23,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110gamma after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50333814
(3-(4-Morpholino-6-(pyridin-3-yl)pyrimidin-2-yl)phe...)Show InChI InChI=1S/C19H18N4O2/c24-16-5-1-3-14(11-16)19-21-17(15-4-2-6-20-13-15)12-18(22-19)23-7-9-25-10-8-23/h1-6,11-13,24H,7-10H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110beta after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333809
(4-(1H-indazol-4-yl)-6-morpholino-N-(2-(pyridin-4-y...)Show SMILES C(Cc1ccncc1)Nc1nc(cc(n1)-c1cccc2[nH]ncc12)N1CCOCC1 Show InChI InChI=1S/C22H23N7O/c1-2-17(18-15-25-28-19(18)3-1)20-14-21(29-10-12-30-13-11-29)27-22(26-20)24-9-6-16-4-7-23-8-5-16/h1-5,7-8,14-15H,6,9-13H2,(H,25,28)(H,24,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333800
(4-(4-(1H-indazol-4-yl)-6-(pyridin-2-ylmethoxy)pyri...)Show SMILES C(Oc1cc(nc(n1)N1CCOCC1)-c1cccc2[nH]ncc12)c1ccccn1 Show InChI InChI=1S/C21H20N6O2/c1-2-7-22-15(4-1)14-29-20-12-19(16-5-3-6-18-17(16)13-23-26-18)24-21(25-20)27-8-10-28-11-9-27/h1-7,12-13H,8-11,14H2,(H,23,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333796
(6-(1H-indazol-4-yl)-2-morpholino-N-(2-(pyridin-3-y...)Show SMILES C(Cc1cccnc1)Nc1cc(nc(n1)N1CCOCC1)-c1cccc2[nH]ncc12 Show InChI InChI=1S/C22H23N7O/c1-4-17(18-15-25-28-19(18)5-1)20-13-21(24-8-6-16-3-2-7-23-14-16)27-22(26-20)29-9-11-30-12-10-29/h1-5,7,13-15H,6,8-12H2,(H,25,28)(H,24,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 660 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333827
(3-(4-(4-Chlorophenyl)-6-morpholinopyrimidin-2-yl)p...)Show SMILES Oc1cccc(c1)-c1nc(cc(n1)-c1ccc(Cl)cc1)N1CCOCC1 Show InChI InChI=1S/C20H18ClN3O2/c21-16-6-4-14(5-7-16)18-13-19(24-8-10-26-11-9-24)23-20(22-18)15-2-1-3-17(25)12-15/h1-7,12-13,25H,8-11H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 690 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50331594
(3-(2-morpholino-6-(pyridin-3-ylmethylamino)pyrimid...)Show InChI InChI=1S/C20H21N5O2/c26-17-5-1-4-16(11-17)18-12-19(22-14-15-3-2-6-21-13-15)24-20(23-18)25-7-9-27-10-8-25/h1-6,11-13,26H,7-10,14H2,(H,22,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 720 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50333821
(3-(2-Morpholino-6-(pyridin-2-ylmethoxy)pyrimidin-4...)Show InChI InChI=1S/C20H20N4O3/c25-17-6-3-4-15(12-17)18-13-19(27-14-16-5-1-2-7-21-16)23-20(22-18)24-8-10-26-11-9-24/h1-7,12-13,25H,8-11,14H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 730 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110gamma after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50333819
(3-(2-Morpholino-6-(2-(pyridin-4-yl)ethylamino)pyri...)Show SMILES Oc1cccc(c1)-c1cc(NCCc2ccncc2)nc(n1)N1CCOCC1 Show InChI InChI=1S/C21H23N5O2/c27-18-3-1-2-17(14-18)19-15-20(23-9-6-16-4-7-22-8-5-16)25-21(24-19)26-10-12-28-13-11-26/h1-5,7-8,14-15,27H,6,9-13H2,(H,23,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 740 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110gamma after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333797
(6-(1H-indazol-4-yl)-2-morpholino-N-(2-(pyridin-4-y...)Show SMILES C(Cc1ccncc1)Nc1cc(nc(n1)N1CCOCC1)-c1cccc2[nH]ncc12 Show InChI InChI=1S/C22H23N7O/c1-2-17(18-15-25-28-19(18)3-1)20-14-21(24-9-6-16-4-7-23-8-5-16)27-22(26-20)29-10-12-30-13-11-29/h1-5,7-8,14-15H,6,9-13H2,(H,25,28)(H,24,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 770 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333808
(4-(1H-indazol-4-yl)-6-morpholino-N-(2-(pyridin-3-y...)Show SMILES C(Cc1cccnc1)Nc1nc(cc(n1)-c1cccc2[nH]ncc12)N1CCOCC1 Show InChI InChI=1S/C22H23N7O/c1-4-17(18-15-25-28-19(18)5-1)20-13-21(29-9-11-30-12-10-29)27-22(26-20)24-8-6-16-3-2-7-23-14-16/h1-5,7,13-15H,6,8-12H2,(H,25,28)(H,24,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 820 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50333817
(3-(2-Morpholino-6-(2-(pyridin-2-yl)ethylamino)pyri...)Show SMILES Oc1cccc(c1)-c1cc(NCCc2ccccn2)nc(n1)N1CCOCC1 Show InChI InChI=1S/C21H23N5O2/c27-18-6-3-4-16(14-18)19-15-20(23-9-7-17-5-1-2-8-22-17)25-21(24-19)26-10-12-28-13-11-26/h1-6,8,14-15,27H,7,9-13H2,(H,23,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 830 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110gamma after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333835
(3-(6-Morpholino-2-(pyridin-2-ylmethoxy)pyrimidin-4...)Show InChI InChI=1S/C20H20N4O3/c25-17-6-3-4-15(12-17)18-13-19(24-8-10-26-11-9-24)23-20(22-18)27-14-16-5-1-2-7-21-16/h1-7,12-13,25H,8-11,14H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 860 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333832
(3-(6-Morpholino-2-(pyridin-4-ylmethylamino)pyrimid...)Show InChI InChI=1S/C20H21N5O2/c26-17-3-1-2-16(12-17)18-13-19(25-8-10-27-11-9-25)24-20(23-18)22-14-15-4-6-21-7-5-15/h1-7,12-13,26H,8-11,14H2,(H,22,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 860 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333831
(3-(6-Morpholino-2-(pyridin-3-ylmethylamino)pyrimid...)Show InChI InChI=1S/C20H21N5O2/c26-17-5-1-4-16(11-17)18-12-19(25-7-9-27-10-8-25)24-20(23-18)22-14-15-3-2-6-21-13-15/h1-6,11-13,26H,7-10,14H2,(H,22,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 880 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333816
(3-(2-Morpholino-6-(pyridin-2-ylmethylamino)pyrimid...)Show InChI InChI=1S/C20H21N5O2/c26-17-6-3-4-15(12-17)18-13-19(22-14-16-5-1-2-7-21-16)24-20(23-18)25-8-10-27-11-9-25/h1-7,12-13,26H,8-11,14H2,(H,22,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50333818
(3-(2-Morpholino-6-(2-(pyridin-3-yl)ethylamino)pyri...)Show SMILES Oc1cccc(c1)-c1cc(NCCc2cccnc2)nc(n1)N1CCOCC1 Show InChI InChI=1S/C21H23N5O2/c27-18-5-1-4-17(13-18)19-14-20(23-8-6-16-3-2-7-22-15-16)25-21(24-19)26-9-11-28-12-10-26/h1-5,7,13-15,27H,6,8-12H2,(H,23,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 960 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110gamma after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333829
(3-(2-Morpholino-6-(pyridin-4-ylmethylamino)pyrimid...)Show InChI InChI=1S/C20H21N5O2/c26-17-3-1-2-16(12-17)18-13-19(22-14-15-4-6-21-7-5-15)24-20(23-18)25-8-10-27-11-9-25/h1-7,12-13,26H,8-11,14H2,(H,22,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333830
(3-(6-Morpholino-2-(pyridin-2-ylmethylamino)pyrimid...)Show InChI InChI=1S/C20H21N5O2/c26-17-6-3-4-15(12-17)18-13-19(25-8-10-27-11-9-25)24-20(23-18)22-14-16-5-1-2-7-21-16/h1-7,12-13,26H,8-11,14H2,(H,22,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333807
(4-(1H-indazol-4-yl)-6-morpholino-N-(2-(pyridin-2-y...)Show SMILES C(Cc1ccccn1)Nc1nc(cc(n1)-c1cccc2[nH]ncc12)N1CCOCC1 Show InChI InChI=1S/C22H23N7O/c1-2-8-23-16(4-1)7-9-24-22-26-20(14-21(27-22)29-10-12-30-13-11-29)17-5-3-6-19-18(17)15-25-28-19/h1-6,8,14-15H,7,9-13H2,(H,25,28)(H,24,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333795
(6-(1H-indazol-4-yl)-2-morpholino-N-(2-(pyridin-2-y...)Show SMILES C(Cc1ccccn1)Nc1cc(nc(n1)N1CCOCC1)-c1cccc2[nH]ncc12 Show InChI InChI=1S/C22H23N7O/c1-2-8-23-16(4-1)7-9-24-21-14-20(17-5-3-6-19-18(17)15-25-28-19)26-22(27-21)29-10-12-30-13-11-29/h1-6,8,14-15H,7,9-13H2,(H,25,28)(H,24,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333812
(4-(6-(1H-indazol-4-yl)-2-(pyridin-2-ylmethoxy)pyri...)Show SMILES C(Oc1nc(cc(n1)-c1cccc2[nH]ncc12)N1CCOCC1)c1ccccn1 Show InChI InChI=1S/C21H20N6O2/c1-2-7-22-15(4-1)14-29-21-24-19(12-20(25-21)27-8-10-28-11-9-27)16-5-3-6-18-17(16)13-23-26-18/h1-7,12-13H,8-11,14H2,(H,23,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.35E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50333819
(3-(2-Morpholino-6-(2-(pyridin-4-yl)ethylamino)pyri...)Show SMILES Oc1cccc(c1)-c1cc(NCCc2ccncc2)nc(n1)N1CCOCC1 Show InChI InChI=1S/C21H23N5O2/c27-18-3-1-2-17(14-18)19-15-20(23-9-6-16-4-7-22-8-5-16)25-21(24-19)26-10-12-28-13-11-26/h1-5,7-8,14-15,27H,6,9-13H2,(H,23,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110beta after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50333818
(3-(2-Morpholino-6-(2-(pyridin-3-yl)ethylamino)pyri...)Show SMILES Oc1cccc(c1)-c1cc(NCCc2cccnc2)nc(n1)N1CCOCC1 Show InChI InChI=1S/C21H23N5O2/c27-18-5-1-4-17(13-18)19-14-20(23-8-6-16-3-2-7-22-15-16)25-21(24-19)26-9-11-28-12-10-26/h1-5,7,13-15,27H,6,8-12H2,(H,23,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110beta after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50333816
(3-(2-Morpholino-6-(pyridin-2-ylmethylamino)pyrimid...)Show InChI InChI=1S/C20H21N5O2/c26-17-6-3-4-15(12-17)18-13-19(22-14-16-5-1-2-7-21-16)24-20(23-18)25-8-10-27-11-9-25/h1-7,12-13,26H,8-11,14H2,(H,22,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110beta after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50333817
(3-(2-Morpholino-6-(2-(pyridin-2-yl)ethylamino)pyri...)Show SMILES Oc1cccc(c1)-c1cc(NCCc2ccccn2)nc(n1)N1CCOCC1 Show InChI InChI=1S/C21H23N5O2/c27-18-6-3-4-16(14-18)19-15-20(23-9-7-17-5-1-2-8-22-17)25-21(24-19)26-10-12-28-13-11-26/h1-6,8,14-15,27H,7,9-13H2,(H,23,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110beta after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50333820
(3-(6-Morpholino-2-(2-(pyridin-2-yl)ethylamino)pyri...)Show SMILES Oc1cccc(c1)-c1cc(nc(NCCc2ccccn2)n1)N1CCOCC1 Show InChI InChI=1S/C21H23N5O2/c27-18-6-3-4-16(14-18)19-15-20(26-10-12-28-13-11-26)25-21(24-19)23-9-7-17-5-1-2-8-22-17/h1-6,8,14-15,27H,7,9-13H2,(H,23,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110beta after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333810
(4-(6-(1H-indol-6-yl)-2-(pyridin-2-ylmethoxy)pyrimi...)Show SMILES C(Oc1nc(cc(n1)-c1ccc2cc[nH]c2c1)N1CCOCC1)c1ccccn1 Show InChI InChI=1S/C22H21N5O2/c1-2-7-23-18(3-1)15-29-22-25-20(14-21(26-22)27-9-11-28-12-10-27)17-5-4-16-6-8-24-19(16)13-17/h1-8,13-14,24H,9-12,15H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333811
(CHEMBL1644598 | N-(4-(6-morpholino-2-(pyridin-2-yl...)Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1cc(nc(OCc2ccccn2)n1)N1CCOCC1 Show InChI InChI=1S/C21H23N5O4S/c1-31(27,28)25-17-7-5-16(6-8-17)19-14-20(26-10-12-29-13-11-26)24-21(23-19)30-15-18-4-2-3-9-22-18/h2-9,14,25H,10-13,15H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333802
(4-(1H-indol-6-yl)-6-morpholino-N-(2-(pyridin-3-yl)...)Show SMILES C(Cc1cccnc1)Nc1nc(cc(n1)-c1ccc2cc[nH]c2c1)N1CCOCC1 Show InChI InChI=1S/C23H24N6O/c1-2-17(16-24-7-1)5-8-26-23-27-21(15-22(28-23)29-10-12-30-13-11-29)19-4-3-18-6-9-25-20(18)14-19/h1-4,6-7,9,14-16,25H,5,8,10-13H2,(H,26,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 7.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50333816
(3-(2-Morpholino-6-(pyridin-2-ylmethylamino)pyrimid...)Show InChI InChI=1S/C20H21N5O2/c26-17-6-3-4-15(12-17)18-13-19(22-14-16-5-1-2-7-21-16)24-20(23-18)25-8-10-27-11-9-25/h1-7,12-13,26H,8-11,14H2,(H,22,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 7.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110gamma after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333801
(4-(1H-indol-6-yl)-6-morpholino-N-(2-(pyridin-2-yl)...)Show SMILES C(Cc1ccccn1)Nc1nc(cc(n1)-c1cccc(c1)-c1ccc2cc[nH]c2c1)N1CCOCC1 Show InChI InChI=1S/C29H28N6O/c1-2-11-30-25(6-1)10-13-32-29-33-27(20-28(34-29)35-14-16-36-17-15-35)24-5-3-4-22(18-24)23-8-7-21-9-12-31-26(21)19-23/h1-9,11-12,18-20,31H,10,13-17H2,(H,32,33,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333806
(CHEMBL1644593 | N-(3-(6-morpholino-2-(2-(pyridin-4...)Show SMILES CS(=O)(=O)Nc1cccc(c1)-c1cc(nc(NCCc2ccncc2)n1)N1CCOCC1 Show InChI InChI=1S/C22H26N6O3S/c1-32(29,30)27-19-4-2-3-18(15-19)20-16-21(28-11-13-31-14-12-28)26-22(25-20)24-10-7-17-5-8-23-9-6-17/h2-6,8-9,15-16,27H,7,10-14H2,1H3,(H,24,25,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333798
(4-(4-(1H-indol-6-yl)-6-(pyridin-2-ylmethoxy)pyrimi...)Show SMILES C(Oc1cc(nc(n1)N1CCOCC1)-c1ccc2cc[nH]c2c1)c1ccccn1 Show InChI InChI=1S/C22H21N5O2/c1-2-7-23-18(3-1)15-29-21-14-20(17-5-4-16-6-8-24-19(16)13-17)25-22(26-21)27-9-11-28-12-10-27/h1-8,13-14,24H,9-12,15H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333822
(4-(2-(3-(Benzyloxy)phenyl)-6-(pyridin-2-yl)pyrimid...)Show SMILES C(Oc1cccc(c1)-c1nc(cc(n1)-c1ccccn1)N1CCOCC1)c1ccccc1 Show InChI InChI=1S/C26H24N4O2/c1-2-7-20(8-3-1)19-32-22-10-6-9-21(17-22)26-28-24(23-11-4-5-12-27-23)18-25(29-26)30-13-15-31-16-14-30/h1-12,17-18H,13-16,19H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333823
(4-(2-(3-(Benzyloxy)phenyl)-6-(pyridin-3-yl)pyrimid...)Show SMILES C(Oc1cccc(c1)-c1nc(cc(n1)-c1cccnc1)N1CCOCC1)c1ccccc1 Show InChI InChI=1S/C26H24N4O2/c1-2-6-20(7-3-1)19-32-23-10-4-8-21(16-23)26-28-24(22-9-5-11-27-18-22)17-25(29-26)30-12-14-31-15-13-30/h1-11,16-18H,12-15,19H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333824
(4-(2-(3-(Benzyloxy)phenyl)-6-(pyridin-4-yl)pyrimid...)Show SMILES C(Oc1cccc(c1)-c1nc(cc(n1)-c1ccncc1)N1CCOCC1)c1ccccc1 Show InChI InChI=1S/C26H24N4O2/c1-2-5-20(6-3-1)19-32-23-8-4-7-22(17-23)26-28-24(21-9-11-27-12-10-21)18-25(29-26)30-13-15-31-16-14-30/h1-12,17-18H,13-16,19H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333839
(CHEMBL1644579 | N-(3-(2-morpholino-6-(2-(pyridin-2...)Show SMILES CS(=O)(=O)Nc1cccc(c1)-c1cc(NCCc2ccccn2)nc(n1)N1CCOCC1 Show InChI InChI=1S/C22H26N6O3S/c1-32(29,30)27-19-7-4-5-17(15-19)20-16-21(24-10-8-18-6-2-3-9-23-18)26-22(25-20)28-11-13-31-14-12-28/h2-7,9,15-16,27H,8,10-14H2,1H3,(H,24,25,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333794
(CHEMBL1644581 | N-(3-(2-morpholino-6-(2-(pyridin-4...)Show SMILES CS(=O)(=O)Nc1cccc(c1)-c1cc(NCCc2ccncc2)nc(n1)N1CCOCC1 Show InChI InChI=1S/C22H26N6O3S/c1-32(29,30)27-19-4-2-3-18(15-19)20-16-21(24-10-7-17-5-8-23-9-6-17)26-22(25-20)28-11-13-31-14-12-28/h2-6,8-9,15-16,27H,7,10-14H2,1H3,(H,24,25,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333804
(CHEMBL1644591 | N-(3-(6-morpholino-2-(2-(pyridin-2...)Show SMILES CS(=O)(=O)Nc1cccc(c1)-c1cc(nc(NCCc2ccccn2)n1)N1CCOCC1 Show InChI InChI=1S/C22H26N6O3S/c1-32(29,30)27-19-7-4-5-17(15-19)20-16-21(28-11-13-31-14-12-28)26-22(25-20)24-10-8-18-6-2-3-9-23-18/h2-7,9,15-16,27H,8,10-14H2,1H3,(H,24,25,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333805
(CHEMBL1644592 | N-(3-(6-morpholino-2-(2-(pyridin-3...)Show SMILES CS(=O)(=O)Nc1cccc(c1)-c1cc(nc(NCCc2cccnc2)n1)N1CCOCC1 Show InChI InChI=1S/C22H26N6O3S/c1-32(29,30)27-19-6-2-5-18(14-19)20-15-21(28-10-12-31-13-11-28)26-22(25-20)24-9-7-17-4-3-8-23-16-17/h2-6,8,14-16,27H,7,9-13H2,1H3,(H,24,25,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333840
(CHEMBL1644580 | N-(3-(2-morpholino-6-(2-(pyridin-3...)Show SMILES CS(=O)(=O)Nc1cccc(c1)-c1cc(NCCc2cccnc2)nc(n1)N1CCOCC1 Show InChI InChI=1S/C22H26N6O3S/c1-32(29,30)27-19-6-2-5-18(14-19)20-15-21(24-9-7-17-4-3-8-23-16-17)26-22(25-20)28-10-12-31-13-11-28/h2-6,8,14-16,27H,7,9-13H2,1H3,(H,24,25,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333826
(4-(2-(3-(Benzyloxy)phenyl)-6-(3,4-dichlorophenyl)p...)Show SMILES Clc1ccc(cc1Cl)-c1cc(nc(n1)-c1cccc(OCc2ccccc2)c1)N1CCOCC1 Show InChI InChI=1S/C27H23Cl2N3O2/c28-23-10-9-20(16-24(23)29)25-17-26(32-11-13-33-14-12-32)31-27(30-25)21-7-4-8-22(15-21)34-18-19-5-2-1-3-6-19/h1-10,15-17H,11-14,18H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333836
(6-(1H-indol-6-yl)-2-morpholino-N-(2-(pyridin-2-yl)...)Show SMILES C(Cc1ccccn1)Nc1cc(nc(n1)N1CCOCC1)-c1ccc2cc[nH]c2c1 Show InChI InChI=1S/C23H24N6O/c1-2-8-24-19(3-1)7-10-26-22-16-21(18-5-4-17-6-9-25-20(17)15-18)27-23(28-22)29-11-13-30-14-12-29/h1-6,8-9,15-16,25H,7,10-14H2,(H,26,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333825
(4-(2-(3-(Benzyloxy)phenyl)-6-(4-chlorophenyl)pyrim...)Show SMILES Clc1ccc(cc1)-c1cc(nc(n1)-c1cccc(OCc2ccccc2)c1)N1CCOCC1 Show InChI InChI=1S/C27H24ClN3O2/c28-23-11-9-21(10-12-23)25-18-26(31-13-15-32-16-14-31)30-27(29-25)22-7-4-8-24(17-22)33-19-20-5-2-1-3-6-20/h1-12,17-18H,13-16,19H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333799
(CHEMBL1644586 | N-(4-(2-morpholino-6-(pyridin-2-yl...)Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1cc(OCc2ccccn2)nc(n1)N1CCOCC1 Show InChI InChI=1S/C21H23N5O4S/c1-31(27,28)25-17-7-5-16(6-8-17)19-14-20(30-15-18-4-2-3-9-22-18)24-21(23-19)26-10-12-29-13-11-26/h2-9,14,25H,10-13,15H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333803
(4-(1H-indol-6-yl)-6-morpholino-N-(2-(pyridin-4-yl)...)Show SMILES C(Cc1ccncc1)Nc1nc(cc(n1)-c1ccc2cc[nH]c2c1)N1CCOCC1 Show InChI InChI=1S/C23H24N6O/c1-2-19(15-20-18(1)6-10-25-20)21-16-22(29-11-13-30-14-12-29)28-23(27-21)26-9-5-17-3-7-24-8-4-17/h1-4,6-8,10,15-16,25H,5,9,11-14H2,(H,26,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333837
(6-(1H-indol-6-yl)-2-morpholino-N-(2-(pyridin-3-yl)...)Show SMILES C(Cc1cccnc1)Nc1cc(nc(n1)N1CCOCC1)-c1ccc2cc[nH]c2c1 Show InChI InChI=1S/C23H24N6O/c1-2-17(16-24-7-1)5-8-26-22-15-21(19-4-3-18-6-9-25-20(18)14-19)27-23(28-22)29-10-12-30-13-11-29/h1-4,6-7,9,14-16,25H,5,8,10-13H2,(H,26,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50333838
(6-(1H-indol-6-yl)-2-morpholino-N-(2-(pyridin-4-yl)...)Show SMILES C(Cc1ccncc1)Nc1cc(nc(n1)N1CCOCC1)-c1ccc2cc[nH]c2c1 Show InChI InChI=1S/C23H24N6O/c1-2-19(15-20-18(1)6-10-25-20)21-16-22(26-9-5-17-3-7-24-8-4-17)28-23(27-21)29-11-13-30-14-12-29/h1-4,6-8,10,15-16,25H,5,9,11-14H2,(H,26,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PI3K p110alpha after 1 hr by radiometric scintillation proximity assay |
Bioorg Med Chem 19: 836-51 (2011)
Article DOI: 10.1016/j.bmc.2010.12.006
BindingDB Entry DOI: 10.7270/Q2DV1K45 |
More data for this
Ligand-Target Pair | |
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