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PubMed code 21257309

Compile data set for download or QSAR
Found 98 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417875
PNG
(CHEMBL1668063)
Show SMILES CCN(C[C@](O)(CNc1cccc2n(ncc12)-c1ccc(F)cc1)C(F)(F)F)C(=O)c1c(Cl)cccc1Cl |r|
Show InChI InChI=1S/C26H22Cl2F4N4O2/c1-2-35(24(37)23-19(27)5-3-6-20(23)28)15-25(38,26(30,31)32)14-33-21-7-4-8-22-18(21)13-34-36(22)17-11-9-16(29)10-12-17/h3-13,33,38H,2,14-15H2,1H3/t25-/m1/s1
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n/an/a 0.0794n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417887
PNG
(CHEMBL1668077)
Show SMILES CC(C)Nc1cccc(c1)-n1ncc2c(NC[C@H](C)NS(=O)(=O)c3c(C)cc(C)cc3C)cc(C)cc12 |r|
Show InChI InChI=1S/C29H37N5O2S/c1-18(2)32-24-9-8-10-25(15-24)34-28-14-20(4)13-27(26(28)17-31-34)30-16-23(7)33-37(35,36)29-21(5)11-19(3)12-22(29)6/h8-15,17-18,23,30,32-33H,16H2,1-7H3/t23-/m0/s1
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n/an/a 0.126n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417890
PNG
(CHEMBL1668080)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1cccc(N[C@H](C)C(N)=O)c1)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C29H36N6O3S/c1-17-10-19(3)28(20(4)11-17)39(37,38)34-21(5)15-31-26-12-18(2)13-27-25(26)16-32-35(27)24-9-7-8-23(14-24)33-22(6)29(30)36/h7-14,16,21-22,31,33-34H,15H2,1-6H3,(H2,30,36)/t21-,22+/m0/s1
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n/an/a 0.200n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417889
PNG
(CHEMBL1668079)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1cccc(NCC(N)=O)c1)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C28H34N6O3S/c1-17-9-19(3)28(20(4)10-17)38(36,37)33-21(5)14-31-25-11-18(2)12-26-24(25)15-32-34(26)23-8-6-7-22(13-23)30-16-27(29)35/h6-13,15,21,30-31,33H,14,16H2,1-5H3,(H2,29,35)/t21-/m0/s1
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n/an/a 0.251n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417875
PNG
(CHEMBL1668063)
Show SMILES CCN(C[C@](O)(CNc1cccc2n(ncc12)-c1ccc(F)cc1)C(F)(F)F)C(=O)c1c(Cl)cccc1Cl |r|
Show InChI InChI=1S/C26H22Cl2F4N4O2/c1-2-35(24(37)23-19(27)5-3-6-20(23)28)15-25(38,26(30,31)32)14-33-21-7-4-8-22-18(21)13-34-36(22)17-11-9-16(29)10-12-17/h3-13,33,38H,2,14-15H2,1H3/t25-/m1/s1
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n/an/a 0.316n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at GR in human A549 cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activity

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417888
PNG
(CHEMBL1668078)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1cccc(NC2CC2)c1)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C29H35N5O2S/c1-18-11-20(3)29(21(4)12-18)37(35,36)33-22(5)16-30-27-13-19(2)14-28-26(27)17-31-34(28)25-8-6-7-24(15-25)32-23-9-10-23/h6-8,11-15,17,22-23,30,32-33H,9-10,16H2,1-5H3/t22-/m0/s1
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n/an/a 0.316n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417891
PNG
(CHEMBL1668081)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1cccc(N[C@@H](C)C(N)=O)c1)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C29H36N6O3S/c1-17-10-19(3)28(20(4)11-17)39(37,38)34-21(5)15-31-26-12-18(2)13-27-25(26)16-32-35(27)24-9-7-8-23(14-24)33-22(6)29(30)36/h7-14,16,21-22,31,33-34H,15H2,1-6H3,(H2,30,36)/t21-,22-/m0/s1
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n/an/a 0.501n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417887
PNG
(CHEMBL1668077)
Show SMILES CC(C)Nc1cccc(c1)-n1ncc2c(NC[C@H](C)NS(=O)(=O)c3c(C)cc(C)cc3C)cc(C)cc12 |r|
Show InChI InChI=1S/C29H37N5O2S/c1-18(2)32-24-9-8-10-25(15-24)34-28-14-20(4)13-27(26(28)17-31-34)30-16-23(7)33-37(35,36)29-21(5)11-19(3)12-22(29)6/h8-15,17-18,23,30,32-33H,16H2,1-7H3/t23-/m0/s1
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n/an/a 0.501n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at GR in human A549 cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activity

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM18207
PNG
((1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dih...)
Show SMILES [H][C@@]12C[C@@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C |c:28,t:24|
Show InChI InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
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n/an/a 1n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417883
PNG
(CHEMBL1668073)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1ccc(NC2CC2)cc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C29H35N5O2S/c1-18-12-20(3)29(21(4)13-18)37(35,36)33-22(5)16-30-27-14-19(2)15-28-26(27)17-31-34(28)25-10-8-24(9-11-25)32-23-6-7-23/h8-15,17,22-23,30,32-33H,6-7,16H2,1-5H3/t22-/m0/s1
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n/an/a 1.26n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417876
PNG
(CHEMBL1668064)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1ccc(F)cc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C26H29FN4O2S/c1-16-10-18(3)26(19(4)11-16)34(32,33)30-20(5)14-28-24-12-17(2)13-25-23(24)15-29-31(25)22-8-6-21(27)7-9-22/h6-13,15,20,28,30H,14H2,1-5H3/t20-/m0/s1
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n/an/a 1.26n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417888
PNG
(CHEMBL1668078)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1cccc(NC2CC2)c1)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C29H35N5O2S/c1-18-11-20(3)29(21(4)12-18)37(35,36)33-22(5)16-30-27-13-19(2)14-28-26(27)17-31-34(28)25-8-6-7-24(15-25)32-23-9-10-23/h6-8,11-15,17,22-23,30,32-33H,9-10,16H2,1-5H3/t22-/m0/s1
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n/an/a 1.26n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at GR in human A549 cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activity

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417891
PNG
(CHEMBL1668081)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1cccc(N[C@@H](C)C(N)=O)c1)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C29H36N6O3S/c1-17-10-19(3)28(20(4)11-17)39(37,38)34-21(5)15-31-26-12-18(2)13-27-25(26)16-32-35(27)24-9-7-8-23(14-24)33-22(6)29(30)36/h7-14,16,21-22,31,33-34H,15H2,1-6H3,(H2,30,36)/t21-,22-/m0/s1
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n/an/a 1.58n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at GR in human A549 cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activity

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417890
PNG
(CHEMBL1668080)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1cccc(N[C@H](C)C(N)=O)c1)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C29H36N6O3S/c1-17-10-19(3)28(20(4)11-17)39(37,38)34-21(5)15-31-26-12-18(2)13-27-25(26)16-32-35(27)24-9-7-8-23(14-24)33-22(6)29(30)36/h7-14,16,21-22,31,33-34H,15H2,1-6H3,(H2,30,36)/t21-,22+/m0/s1
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n/an/a 2n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at GR in human A549 cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activity

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417896
PNG
(CHEMBL1668086)
Show SMILES CC(C)NC(=O)c1cccc(c1)-n1ncc2c(NC[C@H](C)NS(=O)(=O)C3CC3)cc(C)cc12 |r|
Show InChI InChI=1S/C24H31N5O3S/c1-15(2)27-24(30)18-6-5-7-19(12-18)29-23-11-16(3)10-22(21(23)14-26-29)25-13-17(4)28-33(31,32)20-8-9-20/h5-7,10-12,14-15,17,20,25,28H,8-9,13H2,1-4H3,(H,27,30)/t17-/m0/s1
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GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417882
PNG
(CHEMBL1668072)
Show SMILES CC(C)Nc1ccc(cc1)-n1ncc2c(NC[C@H](C)NS(=O)(=O)c3c(C)cc(C)cc3C)cc(C)cc12 |r|
Show InChI InChI=1S/C29H37N5O2S/c1-18(2)32-24-8-10-25(11-9-24)34-28-15-20(4)14-27(26(28)17-31-34)30-16-23(7)33-37(35,36)29-21(5)12-19(3)13-22(29)6/h8-15,17-18,23,30,32-33H,16H2,1-7H3/t23-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417879
PNG
(CHEMBL1668068)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1ccc(cc1)C#N)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C27H29N5O2S/c1-17-10-19(3)27(20(4)11-17)35(33,34)31-21(5)15-29-25-12-18(2)13-26-24(25)16-30-32(26)23-8-6-22(14-28)7-9-23/h6-13,16,21,29,31H,15H2,1-5H3/t21-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417900
PNG
(CHEMBL1668090)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1cccc(c1)C(=O)N(C)[C@H](C)C(N)=O)NS(=O)(=O)C1CC1 |r|
Show InChI InChI=1S/C25H32N6O4S/c1-15-10-22(27-13-16(2)29-36(34,35)20-8-9-20)21-14-28-31(23(21)11-15)19-7-5-6-18(12-19)25(33)30(4)17(3)24(26)32/h5-7,10-12,14,16-17,20,27,29H,8-9,13H2,1-4H3,(H2,26,32)/t16-,17+/m0/s1
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n/an/a 2.51n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417889
PNG
(CHEMBL1668079)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1cccc(NCC(N)=O)c1)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C28H34N6O3S/c1-17-9-19(3)28(20(4)10-17)38(36,37)33-21(5)14-31-25-11-18(2)12-26-24(25)15-32-34(26)23-8-6-7-22(13-23)30-16-27(29)35/h6-13,15,21,30-31,33H,14,16H2,1-5H3,(H2,29,35)/t21-/m0/s1
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n/an/a 2.51n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at GR in human A549 cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activity

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417884
PNG
(CHEMBL1668074)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1ccc(NCC(N)=O)cc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C28H34N6O3S/c1-17-10-19(3)28(20(4)11-17)38(36,37)33-21(5)14-31-25-12-18(2)13-26-24(25)15-32-34(26)23-8-6-22(7-9-23)30-16-27(29)35/h6-13,15,21,30-31,33H,14,16H2,1-5H3,(H2,29,35)/t21-/m0/s1
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n/an/a 3.16n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417902
PNG
(CHEMBL1668089)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1cccc(c1)C(=O)N[C@H](C)C(N)=O)NS(=O)(=O)C1CC1 |r|
Show InChI InChI=1S/C24H30N6O4S/c1-14-9-21(26-12-15(2)29-35(33,34)19-7-8-19)20-13-27-30(22(20)10-14)18-6-4-5-17(11-18)24(32)28-16(3)23(25)31/h4-6,9-11,13,15-16,19,26,29H,7-8,12H2,1-3H3,(H2,25,31)(H,28,32)/t15-,16+/m0/s1
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n/an/a 3.16n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM18207
PNG
((1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dih...)
Show SMILES [H][C@@]12C[C@@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C |c:28,t:24|
Show InChI InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
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n/an/a 3.98n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at GR in human A549 cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activity

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417876
PNG
(CHEMBL1668064)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1ccc(F)cc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C26H29FN4O2S/c1-16-10-18(3)26(19(4)11-16)34(32,33)30-20(5)14-28-24-12-17(2)13-25-23(24)15-29-31(25)22-8-6-21(27)7-9-22/h6-13,15,20,28,30H,14H2,1-5H3/t20-/m0/s1
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n/an/a 3.98n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at GR in human A549 cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activity

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417891
PNG
(CHEMBL1668081)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1cccc(N[C@@H](C)C(N)=O)c1)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C29H36N6O3S/c1-17-10-19(3)28(20(4)11-17)39(37,38)34-21(5)15-31-26-12-18(2)13-27-25(26)16-32-35(27)24-9-7-8-23(14-24)33-22(6)29(30)36/h7-14,16,21-22,31,33-34H,15H2,1-6H3,(H2,30,36)/t21-,22-/m0/s1
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n/an/a 5.01n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Displacement of fluorescent-labelled Dexamethasone from glucocorticoid receptor

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417879
PNG
(CHEMBL1668068)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1ccc(cc1)C#N)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C27H29N5O2S/c1-17-10-19(3)27(20(4)11-17)35(33,34)31-21(5)15-29-25-12-18(2)13-26-24(25)16-30-32(26)23-8-6-22(14-28)7-9-23/h6-13,16,21,29,31H,15H2,1-5H3/t21-/m0/s1
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n/an/a 5.01n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at GR in human A549 cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activity

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417880
PNG
(CHEMBL1668069)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1ccc(cc1)S(C)(=O)=O)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C27H32N4O4S2/c1-17-11-19(3)27(20(4)12-17)37(34,35)30-21(5)15-28-25-13-18(2)14-26-24(25)16-29-31(26)22-7-9-23(10-8-22)36(6,32)33/h7-14,16,21,28,30H,15H2,1-6H3/t21-/m0/s1
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n/an/a 5.01n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417897
PNG
(CHEMBL1668087)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1cccc(c1)C(=O)NCC(N)=O)NS(=O)(=O)C1CC1 |r|
Show InChI InChI=1S/C23H28N6O4S/c1-14-8-20(25-11-15(2)28-34(32,33)18-6-7-18)19-12-27-29(21(19)9-14)17-5-3-4-16(10-17)23(31)26-13-22(24)30/h3-5,8-10,12,15,18,25,28H,6-7,11,13H2,1-2H3,(H2,24,30)(H,26,31)/t15-/m0/s1
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n/an/a 5.01n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417881
PNG
(CHEMBL1668071)
Show SMILES CNc1ccc(cc1)-n1ncc2c(NC[C@H](C)NS(=O)(=O)c3c(C)cc(C)cc3C)cc(C)cc12 |r|
Show InChI InChI=1S/C27H33N5O2S/c1-17-11-19(3)27(20(4)12-17)35(33,34)31-21(5)15-29-25-13-18(2)14-26-24(25)16-30-32(26)23-9-7-22(28-6)8-10-23/h7-14,16,21,28-29,31H,15H2,1-6H3/t21-/m0/s1
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n/an/a 5.01n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417898
PNG
(CHEMBL1668088)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1cccc(c1)C(=O)N[C@@H](C)C(N)=O)NS(=O)(=O)C1CC1 |r|
Show InChI InChI=1S/C24H30N6O4S/c1-14-9-21(26-12-15(2)29-35(33,34)19-7-8-19)20-13-27-30(22(20)10-14)18-6-4-5-17(11-18)24(32)28-16(3)23(25)31/h4-6,9-11,13,15-16,19,26,29H,7-8,12H2,1-3H3,(H2,25,31)(H,28,32)/t15-,16-/m0/s1
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n/an/a 5.01n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417901
PNG
(CHEMBL1668065)
Show SMILES C[C@H](CNS(=O)(=O)c1c(C)cc(C)cc1C)Nc1cc(C)cc2n(ncc12)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C26H29FN4O2S/c1-16-10-18(3)26(19(4)11-16)34(32,33)29-14-20(5)30-24-12-17(2)13-25-23(24)15-28-31(25)22-8-6-21(27)7-9-22/h6-13,15,20,29-30H,14H2,1-5H3/t20-/m1/s1
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n/an/a 6.31n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417887
PNG
(CHEMBL1668077)
Show SMILES CC(C)Nc1cccc(c1)-n1ncc2c(NC[C@H](C)NS(=O)(=O)c3c(C)cc(C)cc3C)cc(C)cc12 |r|
Show InChI InChI=1S/C29H37N5O2S/c1-18(2)32-24-9-8-10-25(15-24)34-28-14-20(4)13-27(26(28)17-31-34)30-16-23(7)33-37(35,36)29-21(5)11-19(3)12-22(29)6/h8-15,17-18,23,30,32-33H,16H2,1-7H3/t23-/m0/s1
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n/an/a 6.31n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Displacement of fluorescent-labelled Dexamethasone from glucocorticoid receptor

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417883
PNG
(CHEMBL1668073)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1ccc(NC2CC2)cc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C29H35N5O2S/c1-18-12-20(3)29(21(4)13-18)37(35,36)33-22(5)16-30-27-14-19(2)15-28-26(27)17-31-34(28)25-10-8-24(9-11-25)32-23-6-7-23/h8-15,17,22-23,30,32-33H,6-7,16H2,1-5H3/t22-/m0/s1
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n/an/a 7.94n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at GR in human A549 cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activity

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417886
PNG
(CHEMBL1668076)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1ccc(N[C@@H](C)C(N)=O)cc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C29H36N6O3S/c1-17-11-19(3)28(20(4)12-17)39(37,38)34-21(5)15-31-26-13-18(2)14-27-25(26)16-32-35(27)24-9-7-23(8-10-24)33-22(6)29(30)36/h7-14,16,21-22,31,33-34H,15H2,1-6H3,(H2,30,36)/t21-,22-/m0/s1
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n/an/a 7.94n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417883
PNG
(CHEMBL1668073)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1ccc(NC2CC2)cc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C29H35N5O2S/c1-18-12-20(3)29(21(4)13-18)37(35,36)33-22(5)16-30-27-14-19(2)15-28-26(27)17-31-34(28)25-10-8-24(9-11-25)32-23-6-7-23/h8-15,17,22-23,30,32-33H,6-7,16H2,1-5H3/t22-/m0/s1
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n/an/a 7.94n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Displacement of fluorescent-labelled Dexamethasone from glucocorticoid receptor

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417885
PNG
(CHEMBL1668075)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1ccc(N[C@H](C)C(N)=O)cc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C29H36N6O3S/c1-17-11-19(3)28(20(4)12-17)39(37,38)34-21(5)15-31-26-13-18(2)14-27-25(26)16-32-35(27)24-9-7-23(8-10-24)33-22(6)29(30)36/h7-14,16,21-22,31,33-34H,15H2,1-6H3,(H2,30,36)/t21-,22+/m0/s1
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n/an/a 7.94n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417895
PNG
(CHEMBL1668085)
Show SMILES CC(C)NC(=O)c1cccc(c1)-n1ncc2c(NC[C@H](C)NS(=O)(=O)C(C)C)cc(C)cc12 |r|
Show InChI InChI=1S/C24H33N5O3S/c1-15(2)27-24(30)19-8-7-9-20(12-19)29-23-11-17(5)10-22(21(23)14-26-29)25-13-18(6)28-33(31,32)16(3)4/h7-12,14-16,18,25,28H,13H2,1-6H3,(H,27,30)/t18-/m0/s1
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n/an/a 7.94n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417888
PNG
(CHEMBL1668078)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1cccc(NC2CC2)c1)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C29H35N5O2S/c1-18-11-20(3)29(21(4)12-18)37(35,36)33-22(5)16-30-27-13-19(2)14-28-26(27)17-31-34(28)25-8-6-7-24(15-25)32-23-9-10-23/h6-8,11-15,17,22-23,30,32-33H,9-10,16H2,1-5H3/t22-/m0/s1
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n/an/a 7.94n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Displacement of fluorescent-labelled Dexamethasone from glucocorticoid receptor

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417897
PNG
(CHEMBL1668087)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1cccc(c1)C(=O)NCC(N)=O)NS(=O)(=O)C1CC1 |r|
Show InChI InChI=1S/C23H28N6O4S/c1-14-8-20(25-11-15(2)28-34(32,33)18-6-7-18)19-12-27-29(21(19)9-14)17-5-3-4-16(10-17)23(31)26-13-22(24)30/h3-5,8-10,12,15,18,25,28H,6-7,11,13H2,1-2H3,(H2,24,30)(H,26,31)/t15-/m0/s1
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n/an/a 7.94n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Displacement of fluorescent-labelled Dexamethasone from glucocorticoid receptor

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417877
PNG
(CHEMBL1668066)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1cccc(F)c1)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C26H29FN4O2S/c1-16-9-18(3)26(19(4)10-16)34(32,33)30-20(5)14-28-24-11-17(2)12-25-23(24)15-29-31(25)22-8-6-7-21(27)13-22/h6-13,15,20,28,30H,14H2,1-5H3/t20-/m0/s1
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n/an/a 7.94n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417882
PNG
(CHEMBL1668072)
Show SMILES CC(C)Nc1ccc(cc1)-n1ncc2c(NC[C@H](C)NS(=O)(=O)c3c(C)cc(C)cc3C)cc(C)cc12 |r|
Show InChI InChI=1S/C29H37N5O2S/c1-18(2)32-24-8-10-25(11-9-24)34-28-15-20(4)14-27(26(28)17-31-34)30-16-23(7)33-37(35,36)29-21(5)12-19(3)13-22(29)6/h8-15,17-18,23,30,32-33H,16H2,1-7H3/t23-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at GR in human A549 cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activity

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417889
PNG
(CHEMBL1668079)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1cccc(NCC(N)=O)c1)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C28H34N6O3S/c1-17-9-19(3)28(20(4)10-17)38(36,37)33-21(5)14-31-25-11-18(2)12-26-24(25)15-32-34(26)23-8-6-7-22(13-23)30-16-27(29)35/h6-13,15,21,30-31,33H,14,16H2,1-5H3,(H2,29,35)/t21-/m0/s1
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n/an/a 12.6n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Displacement of fluorescent-labelled Dexamethasone from glucocorticoid receptor

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM18207
PNG
((1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dih...)
Show SMILES [H][C@@]12C[C@@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C |c:28,t:24|
Show InChI InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
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n/an/a 12.6n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Displacement of fluorescent-labelled Dexamethasone from glucocorticoid receptor

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417882
PNG
(CHEMBL1668072)
Show SMILES CC(C)Nc1ccc(cc1)-n1ncc2c(NC[C@H](C)NS(=O)(=O)c3c(C)cc(C)cc3C)cc(C)cc12 |r|
Show InChI InChI=1S/C29H37N5O2S/c1-18(2)32-24-8-10-25(11-9-24)34-28-15-20(4)14-27(26(28)17-31-34)30-16-23(7)33-37(35,36)29-21(5)12-19(3)13-22(29)6/h8-15,17-18,23,30,32-33H,16H2,1-7H3/t23-/m0/s1
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n/an/a 12.6n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Displacement of fluorescent-labelled Dexamethasone from glucocorticoid receptor

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417894
PNG
(CHEMBL1668084)
Show SMILES CCCS(=O)(=O)N[C@@H](C)CNc1cc(C)cc2n(ncc12)-c1cccc(c1)C(=O)NC(C)C |r|
Show InChI InChI=1S/C24H33N5O3S/c1-6-10-33(31,32)28-18(5)14-25-22-11-17(4)12-23-21(22)15-26-29(23)20-9-7-8-19(13-20)24(30)27-16(2)3/h7-9,11-13,15-16,18,25,28H,6,10,14H2,1-5H3,(H,27,30)/t18-/m0/s1
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n/an/a 12.6n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Displacement of fluorescent-labelled Dexamethasone from glucocorticoid receptor

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417878
PNG
(CHEMBL1668067)
Show SMILES COc1ccc(cc1)-n1ncc2c(NC[C@H](C)NS(=O)(=O)c3c(C)cc(C)cc3C)cc(C)cc12 |r|
Show InChI InChI=1S/C27H32N4O3S/c1-17-11-19(3)27(20(4)12-17)35(32,33)30-21(5)15-28-25-13-18(2)14-26-24(25)16-29-31(26)22-7-9-23(34-6)10-8-22/h7-14,16,21,28,30H,15H2,1-6H3/t21-/m0/s1
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n/an/a 12.6n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417880
PNG
(CHEMBL1668069)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1ccc(cc1)S(C)(=O)=O)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C27H32N4O4S2/c1-17-11-19(3)27(20(4)12-17)37(34,35)30-21(5)15-28-25-13-18(2)14-26-24(25)16-29-31(26)22-7-9-23(10-8-22)36(6,32)33/h7-14,16,21,28,30H,15H2,1-6H3/t21-/m0/s1
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n/an/a 12.6n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at GR in human A549 cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activity

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417901
PNG
(CHEMBL1668065)
Show SMILES C[C@H](CNS(=O)(=O)c1c(C)cc(C)cc1C)Nc1cc(C)cc2n(ncc12)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C26H29FN4O2S/c1-16-10-18(3)26(19(4)11-16)34(32,33)29-14-20(5)30-24-12-17(2)13-25-23(24)15-28-31(25)22-8-6-21(27)7-9-22/h6-13,15,20,29-30H,14H2,1-5H3/t20-/m1/s1
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n/an/a 12.6n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Displacement of fluorescent-labelled Dexamethasone from glucocorticoid receptor

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417896
PNG
(CHEMBL1668086)
Show SMILES CC(C)NC(=O)c1cccc(c1)-n1ncc2c(NC[C@H](C)NS(=O)(=O)C3CC3)cc(C)cc12 |r|
Show InChI InChI=1S/C24H31N5O3S/c1-15(2)27-24(30)18-6-5-7-19(12-18)29-23-11-16(3)10-22(21(23)14-26-29)25-13-17(4)28-33(31,32)20-8-9-20/h5-7,10-12,14-15,17,20,25,28H,8-9,13H2,1-4H3,(H,27,30)/t17-/m0/s1
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n/an/a 12.6n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at GR in human A549 cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activity

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417884
PNG
(CHEMBL1668074)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1ccc(NCC(N)=O)cc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C28H34N6O3S/c1-17-10-19(3)28(20(4)11-17)38(36,37)33-21(5)14-31-25-12-18(2)13-26-24(25)15-32-34(26)23-8-6-22(7-9-23)30-16-27(29)35/h6-13,15,21,30-31,33H,14,16H2,1-5H3,(H2,29,35)/t21-/m0/s1
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n/an/a 15.8n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Displacement of fluorescent-labelled Dexamethasone from glucocorticoid receptor

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417876
PNG
(CHEMBL1668064)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1ccc(F)cc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C26H29FN4O2S/c1-16-10-18(3)26(19(4)11-16)34(32,33)30-20(5)14-28-24-12-17(2)13-25-23(24)15-29-31(25)22-8-6-21(27)7-9-22/h6-13,15,20,28,30H,14H2,1-5H3/t20-/m0/s1
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n/an/a 15.8n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Displacement of fluorescent-labelled Dexamethasone from glucocorticoid receptor

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417879
PNG
(CHEMBL1668068)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1ccc(cc1)C#N)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C27H29N5O2S/c1-17-10-19(3)27(20(4)11-17)35(33,34)31-21(5)15-29-25-12-18(2)13-26-24(25)16-30-32(26)23-8-6-22(14-28)7-9-23/h6-13,16,21,29,31H,15H2,1-5H3/t21-/m0/s1
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n/an/a 15.8n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Displacement of fluorescent-labelled Dexamethasone from glucocorticoid receptor

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417896
PNG
(CHEMBL1668086)
Show SMILES CC(C)NC(=O)c1cccc(c1)-n1ncc2c(NC[C@H](C)NS(=O)(=O)C3CC3)cc(C)cc12 |r|
Show InChI InChI=1S/C24H31N5O3S/c1-15(2)27-24(30)18-6-5-7-19(12-18)29-23-11-16(3)10-22(21(23)14-26-29)25-13-17(4)28-33(31,32)20-8-9-20/h5-7,10-12,14-15,17,20,25,28H,8-9,13H2,1-4H3,(H,27,30)/t17-/m0/s1
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n/an/a 15.8n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Displacement of fluorescent-labelled Dexamethasone from glucocorticoid receptor

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417877
PNG
(CHEMBL1668066)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1cccc(F)c1)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C26H29FN4O2S/c1-16-9-18(3)26(19(4)10-16)34(32,33)30-20(5)14-28-24-11-17(2)12-25-23(24)15-29-31(25)22-8-6-7-21(27)13-22/h6-13,15,20,28,30H,14H2,1-5H3/t20-/m0/s1
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n/an/a 15.8n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Displacement of fluorescent-labelled Dexamethasone from glucocorticoid receptor

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417890
PNG
(CHEMBL1668080)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1cccc(N[C@H](C)C(N)=O)c1)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C29H36N6O3S/c1-17-10-19(3)28(20(4)11-17)39(37,38)34-21(5)15-31-26-12-18(2)13-27-25(26)16-32-35(27)24-9-7-8-23(14-24)33-22(6)29(30)36/h7-14,16,21-22,31,33-34H,15H2,1-6H3,(H2,30,36)/t21-,22+/m0/s1
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n/an/a 15.8n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Displacement of fluorescent-labelled Dexamethasone from glucocorticoid receptor

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417875
PNG
(CHEMBL1668063)
Show SMILES CCN(C[C@](O)(CNc1cccc2n(ncc12)-c1ccc(F)cc1)C(F)(F)F)C(=O)c1c(Cl)cccc1Cl |r|
Show InChI InChI=1S/C26H22Cl2F4N4O2/c1-2-35(24(37)23-19(27)5-3-6-20(23)28)15-25(38,26(30,31)32)14-33-21-7-4-8-22-18(21)13-34-36(22)17-11-9-16(29)10-12-17/h3-13,33,38H,2,14-15H2,1H3/t25-/m1/s1
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n/an/a 15.8n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Displacement of fluorescent-labelled Dexamethasone from glucocorticoid receptor

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417886
PNG
(CHEMBL1668076)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1ccc(N[C@@H](C)C(N)=O)cc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C29H36N6O3S/c1-17-11-19(3)28(20(4)12-17)39(37,38)34-21(5)15-31-26-13-18(2)14-27-25(26)16-32-35(27)24-9-7-23(8-10-24)33-22(6)29(30)36/h7-14,16,21-22,31,33-34H,15H2,1-6H3,(H2,30,36)/t21-,22-/m0/s1
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n/an/a 15.8n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at GR in human A549 cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activity

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417878
PNG
(CHEMBL1668067)
Show SMILES COc1ccc(cc1)-n1ncc2c(NC[C@H](C)NS(=O)(=O)c3c(C)cc(C)cc3C)cc(C)cc12 |r|
Show InChI InChI=1S/C27H32N4O3S/c1-17-11-19(3)27(20(4)12-17)35(32,33)30-21(5)15-28-25-13-18(2)14-26-24(25)16-29-31(26)22-7-9-23(34-6)10-8-22/h7-14,16,21,28,30H,15H2,1-6H3/t21-/m0/s1
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n/an/a 15.8n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Displacement of fluorescent-labelled Dexamethasone from glucocorticoid receptor

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417892
PNG
(CHEMBL1668082)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1cccc(c1)N1CCCC(CO)C1)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C32H41N5O3S/c1-21-12-23(3)32(24(4)13-21)41(39,40)35-25(5)17-33-30-14-22(2)15-31-29(30)18-34-37(31)28-10-6-9-27(16-28)36-11-7-8-26(19-36)20-38/h6,9-10,12-16,18,25-26,33,35,38H,7-8,11,17,19-20H2,1-5H3/t25-,26?/m0/s1
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n/an/a 19.9n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417894
PNG
(CHEMBL1668084)
Show SMILES CCCS(=O)(=O)N[C@@H](C)CNc1cc(C)cc2n(ncc12)-c1cccc(c1)C(=O)NC(C)C |r|
Show InChI InChI=1S/C24H33N5O3S/c1-6-10-33(31,32)28-18(5)14-25-22-11-17(4)12-23-21(22)15-26-29(23)20-9-7-8-19(13-20)24(30)27-16(2)3/h7-9,11-13,15-16,18,25,28H,6,10,14H2,1-5H3,(H,27,30)/t18-/m0/s1
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n/an/a 19.9n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417881
PNG
(CHEMBL1668071)
Show SMILES CNc1ccc(cc1)-n1ncc2c(NC[C@H](C)NS(=O)(=O)c3c(C)cc(C)cc3C)cc(C)cc12 |r|
Show InChI InChI=1S/C27H33N5O2S/c1-17-11-19(3)27(20(4)12-17)35(33,34)31-21(5)15-29-25-13-18(2)14-26-24(25)16-30-32(26)23-9-7-22(28-6)8-10-23/h7-14,16,21,28-29,31H,15H2,1-6H3/t21-/m0/s1
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n/an/a 19.9n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Displacement of fluorescent-labelled Dexamethasone from glucocorticoid receptor

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417892
PNG
(CHEMBL1668082)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1cccc(c1)N1CCCC(CO)C1)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C32H41N5O3S/c1-21-12-23(3)32(24(4)13-21)41(39,40)35-25(5)17-33-30-14-22(2)15-31-29(30)18-34-37(31)28-10-6-9-27(16-28)36-11-7-8-26(19-36)20-38/h6,9-10,12-16,18,25-26,33,35,38H,7-8,11,17,19-20H2,1-5H3/t25-,26?/m0/s1
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n/an/a 20n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417892
PNG
(CHEMBL1668082)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1cccc(c1)N1CCCC(CO)C1)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C32H41N5O3S/c1-21-12-23(3)32(24(4)13-21)41(39,40)35-25(5)17-33-30-14-22(2)15-31-29(30)18-34-37(31)28-10-6-9-27(16-28)36-11-7-8-26(19-36)20-38/h6,9-10,12-16,18,25-26,33,35,38H,7-8,11,17,19-20H2,1-5H3/t25-,26?/m0/s1
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n/an/a 20n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417892
PNG
(CHEMBL1668082)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1cccc(c1)N1CCCC(CO)C1)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C32H41N5O3S/c1-21-12-23(3)32(24(4)13-21)41(39,40)35-25(5)17-33-30-14-22(2)15-31-29(30)18-34-37(31)28-10-6-9-27(16-28)36-11-7-8-26(19-36)20-38/h6,9-10,12-16,18,25-26,33,35,38H,7-8,11,17,19-20H2,1-5H3/t25-,26?/m0/s1
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n/an/a 25.1n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Displacement of fluorescent-labelled Dexamethasone from glucocorticoid receptor

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417892
PNG
(CHEMBL1668082)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1cccc(c1)N1CCCC(CO)C1)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C32H41N5O3S/c1-21-12-23(3)32(24(4)13-21)41(39,40)35-25(5)17-33-30-14-22(2)15-31-29(30)18-34-37(31)28-10-6-9-27(16-28)36-11-7-8-26(19-36)20-38/h6,9-10,12-16,18,25-26,33,35,38H,7-8,11,17,19-20H2,1-5H3/t25-,26?/m0/s1
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n/an/a 25.1n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Displacement of fluorescent-labelled Dexamethasone from glucocorticoid receptor

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417892
PNG
(CHEMBL1668082)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1cccc(c1)N1CCCC(CO)C1)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C32H41N5O3S/c1-21-12-23(3)32(24(4)13-21)41(39,40)35-25(5)17-33-30-14-22(2)15-31-29(30)18-34-37(31)28-10-6-9-27(16-28)36-11-7-8-26(19-36)20-38/h6,9-10,12-16,18,25-26,33,35,38H,7-8,11,17,19-20H2,1-5H3/t25-,26?/m0/s1
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n/an/a 25.1n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Displacement of fluorescent-labelled Dexamethasone from glucocorticoid receptor

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417885
PNG
(CHEMBL1668075)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1ccc(N[C@H](C)C(N)=O)cc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C29H36N6O3S/c1-17-11-19(3)28(20(4)12-17)39(37,38)34-21(5)15-31-26-13-18(2)14-27-25(26)16-32-35(27)24-9-7-23(8-10-24)33-22(6)29(30)36/h7-14,16,21-22,31,33-34H,15H2,1-6H3,(H2,30,36)/t21-,22+/m0/s1
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n/an/a 25.1n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Displacement of fluorescent-labelled Dexamethasone from glucocorticoid receptor

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417877
PNG
(CHEMBL1668066)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1cccc(F)c1)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C26H29FN4O2S/c1-16-9-18(3)26(19(4)10-16)34(32,33)30-20(5)14-28-24-11-17(2)12-25-23(24)15-29-31(25)22-8-6-7-21(27)13-22/h6-13,15,20,28,30H,14H2,1-5H3/t20-/m0/s1
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n/an/a 25.1n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at GR in human A549 cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activity

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417886
PNG
(CHEMBL1668076)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1ccc(N[C@@H](C)C(N)=O)cc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C29H36N6O3S/c1-17-11-19(3)28(20(4)12-17)39(37,38)34-21(5)15-31-26-13-18(2)14-27-25(26)16-32-35(27)24-9-7-23(8-10-24)33-22(6)29(30)36/h7-14,16,21-22,31,33-34H,15H2,1-6H3,(H2,30,36)/t21-,22-/m0/s1
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n/an/a 31.6n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Displacement of fluorescent-labelled Dexamethasone from glucocorticoid receptor

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417902
PNG
(CHEMBL1668089)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1cccc(c1)C(=O)N[C@H](C)C(N)=O)NS(=O)(=O)C1CC1 |r|
Show InChI InChI=1S/C24H30N6O4S/c1-14-9-21(26-12-15(2)29-35(33,34)19-7-8-19)20-13-27-30(22(20)10-14)18-6-4-5-17(11-18)24(32)28-16(3)23(25)31/h4-6,9-11,13,15-16,19,26,29H,7-8,12H2,1-3H3,(H2,25,31)(H,28,32)/t15-,16+/m0/s1
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n/an/a 31.6n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Displacement of fluorescent-labelled Dexamethasone from glucocorticoid receptor

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417880
PNG
(CHEMBL1668069)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1ccc(cc1)S(C)(=O)=O)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C27H32N4O4S2/c1-17-11-19(3)27(20(4)12-17)37(34,35)30-21(5)15-28-25-13-18(2)14-26-24(25)16-29-31(26)22-7-9-23(10-8-22)36(6,32)33/h7-14,16,21,28,30H,15H2,1-6H3/t21-/m0/s1
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n/an/a 31.6n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Displacement of fluorescent-labelled Dexamethasone from glucocorticoid receptor

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417900
PNG
(CHEMBL1668090)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1cccc(c1)C(=O)N(C)[C@H](C)C(N)=O)NS(=O)(=O)C1CC1 |r|
Show InChI InChI=1S/C25H32N6O4S/c1-15-10-22(27-13-16(2)29-36(34,35)20-8-9-20)21-14-28-31(23(21)11-15)19-7-5-6-18(12-19)25(33)30(4)17(3)24(26)32/h5-7,10-12,14,16-17,20,27,29H,8-9,13H2,1-4H3,(H2,26,32)/t16-,17+/m0/s1
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n/an/a 31.6n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Displacement of fluorescent-labelled Dexamethasone from glucocorticoid receptor

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417898
PNG
(CHEMBL1668088)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1cccc(c1)C(=O)N[C@@H](C)C(N)=O)NS(=O)(=O)C1CC1 |r|
Show InChI InChI=1S/C24H30N6O4S/c1-14-9-21(26-12-15(2)29-35(33,34)19-7-8-19)20-13-27-30(22(20)10-14)18-6-4-5-17(11-18)24(32)28-16(3)23(25)31/h4-6,9-11,13,15-16,19,26,29H,7-8,12H2,1-3H3,(H2,25,31)(H,28,32)/t15-,16-/m0/s1
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n/an/a 39.8n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Displacement of fluorescent-labelled Dexamethasone from glucocorticoid receptor

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417895
PNG
(CHEMBL1668085)
Show SMILES CC(C)NC(=O)c1cccc(c1)-n1ncc2c(NC[C@H](C)NS(=O)(=O)C(C)C)cc(C)cc12 |r|
Show InChI InChI=1S/C24H33N5O3S/c1-15(2)27-24(30)19-8-7-9-20(12-19)29-23-11-17(5)10-22(21(23)14-26-29)25-13-18(6)28-33(31,32)16(3)4/h7-12,14-16,18,25,28H,13H2,1-6H3,(H,27,30)/t18-/m0/s1
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n/an/a 39.8n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Displacement of fluorescent-labelled Dexamethasone from glucocorticoid receptor

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417895
PNG
(CHEMBL1668085)
Show SMILES CC(C)NC(=O)c1cccc(c1)-n1ncc2c(NC[C@H](C)NS(=O)(=O)C(C)C)cc(C)cc12 |r|
Show InChI InChI=1S/C24H33N5O3S/c1-15(2)27-24(30)19-8-7-9-20(12-19)29-23-11-17(5)10-22(21(23)14-26-29)25-13-18(6)28-33(31,32)16(3)4/h7-12,14-16,18,25,28H,13H2,1-6H3,(H,27,30)/t18-/m0/s1
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n/an/a 50.1n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at GR in human A549 cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activity

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417903
PNG
(CHEMBL1668070)
Show SMILES COc1cccc(c1)-n1ncc2c(NC[C@H](C)NS(=O)(=O)c3c(C)cc(C)cc3C)cc(C)cc12 |r|
Show InChI InChI=1S/C27H32N4O3S/c1-17-10-19(3)27(20(4)11-17)35(32,33)30-21(5)15-28-25-12-18(2)13-26-24(25)16-29-31(26)22-8-7-9-23(14-22)34-6/h7-14,16,21,28,30H,15H2,1-6H3/t21-/m0/s1
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n/an/a 50.1n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417901
PNG
(CHEMBL1668065)
Show SMILES C[C@H](CNS(=O)(=O)c1c(C)cc(C)cc1C)Nc1cc(C)cc2n(ncc12)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C26H29FN4O2S/c1-16-10-18(3)26(19(4)11-16)34(32,33)29-14-20(5)30-24-12-17(2)13-25-23(24)15-28-31(25)22-8-6-21(27)7-9-22/h6-13,15,20,29-30H,14H2,1-5H3/t20-/m1/s1
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n/an/a 50.1n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at GR in human A549 cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activity

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417878
PNG
(CHEMBL1668067)
Show SMILES COc1ccc(cc1)-n1ncc2c(NC[C@H](C)NS(=O)(=O)c3c(C)cc(C)cc3C)cc(C)cc12 |r|
Show InChI InChI=1S/C27H32N4O3S/c1-17-11-19(3)27(20(4)12-17)35(32,33)30-21(5)15-28-25-13-18(2)14-26-24(25)16-29-31(26)22-7-9-23(34-6)10-8-22/h7-14,16,21,28,30H,15H2,1-6H3/t21-/m0/s1
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n/an/a 50.1n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at GR in human A549 cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activity

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417900
PNG
(CHEMBL1668090)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1cccc(c1)C(=O)N(C)[C@H](C)C(N)=O)NS(=O)(=O)C1CC1 |r|
Show InChI InChI=1S/C25H32N6O4S/c1-15-10-22(27-13-16(2)29-36(34,35)20-8-9-20)21-14-28-31(23(21)11-15)19-7-5-6-18(12-19)25(33)30(4)17(3)24(26)32/h5-7,10-12,14,16-17,20,27,29H,8-9,13H2,1-4H3,(H2,26,32)/t16-,17+/m0/s1
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n/an/a 50.1n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at GR in human A549 cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activity

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417884
PNG
(CHEMBL1668074)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1ccc(NCC(N)=O)cc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C28H34N6O3S/c1-17-10-19(3)28(20(4)11-17)38(36,37)33-21(5)14-31-25-12-18(2)13-26-24(25)15-32-34(26)23-8-6-22(7-9-23)30-16-27(29)35/h6-13,15,21,30-31,33H,14,16H2,1-5H3,(H2,29,35)/t21-/m0/s1
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n/an/a 63.1n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at GR in human A549 cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activity

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417894
PNG
(CHEMBL1668084)
Show SMILES CCCS(=O)(=O)N[C@@H](C)CNc1cc(C)cc2n(ncc12)-c1cccc(c1)C(=O)NC(C)C |r|
Show InChI InChI=1S/C24H33N5O3S/c1-6-10-33(31,32)28-18(5)14-25-22-11-17(4)12-23-21(22)15-26-29(23)20-9-7-8-19(13-20)24(30)27-16(2)3/h7-9,11-13,15-16,18,25,28H,6,10,14H2,1-5H3,(H,27,30)/t18-/m0/s1
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n/an/a 79.4n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at GR in human A549 cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activity

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417899
PNG
(CHEMBL1668092)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1cccc(c1)C(=O)N1CCCC(CO)C1)NS(=O)(=O)C1CC1 |r|
Show InChI InChI=1S/C27H35N5O4S/c1-18-11-25(28-14-19(2)30-37(35,36)23-8-9-23)24-15-29-32(26(24)12-18)22-7-3-6-21(13-22)27(34)31-10-4-5-20(16-31)17-33/h3,6-7,11-13,15,19-20,23,28,30,33H,4-5,8-10,14,16-17H2,1-2H3/t19-,20?/m0/s1
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n/an/a 126n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Displacement of fluorescent-labelled Dexamethasone from glucocorticoid receptor

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417902
PNG
(CHEMBL1668089)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1cccc(c1)C(=O)N[C@H](C)C(N)=O)NS(=O)(=O)C1CC1 |r|
Show InChI InChI=1S/C24H30N6O4S/c1-14-9-21(26-12-15(2)29-35(33,34)19-7-8-19)20-13-27-30(22(20)10-14)18-6-4-5-17(11-18)24(32)28-16(3)23(25)31/h4-6,9-11,13,15-16,19,26,29H,7-8,12H2,1-3H3,(H2,25,31)(H,28,32)/t15-,16+/m0/s1
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n/an/a 126n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at GR in human A549 cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activity

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417893
PNG
(CHEMBL1668083)
Show SMILES CC(C)NC(=O)c1cccc(c1)-n1ncc2c(NC[C@H](C)NS(C)(=O)=O)cc(C)cc12 |r|
Show InChI InChI=1S/C22H29N5O3S/c1-14(2)25-22(28)17-7-6-8-18(11-17)27-21-10-15(3)9-20(19(21)13-24-27)23-12-16(4)26-31(5,29)30/h6-11,13-14,16,23,26H,12H2,1-5H3,(H,25,28)/t16-/m0/s1
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n/an/a 126n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Displacement of fluorescent-labelled Dexamethasone from glucocorticoid receptor

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417874
PNG
(CHEMBL1668091)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1cccc(c1)C(=O)N1CCC[C@H]1C(N)=O)NS(=O)(=O)C1CC1 |r|
Show InChI InChI=1S/C26H32N6O4S/c1-16-11-22(28-14-17(2)30-37(35,36)20-8-9-20)21-15-29-32(24(21)12-16)19-6-3-5-18(13-19)26(34)31-10-4-7-23(31)25(27)33/h3,5-6,11-13,15,17,20,23,28,30H,4,7-10,14H2,1-2H3,(H2,27,33)/t17-,23-/m0/s1
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n/an/a 158n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Displacement of fluorescent-labelled Dexamethasone from glucocorticoid receptor

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417885
PNG
(CHEMBL1668075)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1ccc(N[C@H](C)C(N)=O)cc1)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C29H36N6O3S/c1-17-11-19(3)28(20(4)12-17)39(37,38)34-21(5)15-31-26-13-18(2)14-27-25(26)16-32-35(27)24-9-7-23(8-10-24)33-22(6)29(30)36/h7-14,16,21-22,31,33-34H,15H2,1-6H3,(H2,30,36)/t21-,22+/m0/s1
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n/an/a 158n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at GR in human A549 cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activity

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417898
PNG
(CHEMBL1668088)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1cccc(c1)C(=O)N[C@@H](C)C(N)=O)NS(=O)(=O)C1CC1 |r|
Show InChI InChI=1S/C24H30N6O4S/c1-14-9-21(26-12-15(2)29-35(33,34)19-7-8-19)20-13-27-30(22(20)10-14)18-6-4-5-17(11-18)24(32)28-16(3)23(25)31/h4-6,9-11,13,15-16,19,26,29H,7-8,12H2,1-3H3,(H2,25,31)(H,28,32)/t15-,16-/m0/s1
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n/an/a 200n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at GR in human A549 cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activity

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417903
PNG
(CHEMBL1668070)
Show SMILES COc1cccc(c1)-n1ncc2c(NC[C@H](C)NS(=O)(=O)c3c(C)cc(C)cc3C)cc(C)cc12 |r|
Show InChI InChI=1S/C27H32N4O3S/c1-17-10-19(3)27(20(4)11-17)35(32,33)30-21(5)15-28-25-12-18(2)13-26-24(25)16-29-31(26)22-8-7-9-23(14-22)34-6/h7-14,16,21,28,30H,15H2,1-6H3/t21-/m0/s1
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n/an/a 200n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at GR in human A549 cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activity

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417893
PNG
(CHEMBL1668083)
Show SMILES CC(C)NC(=O)c1cccc(c1)-n1ncc2c(NC[C@H](C)NS(C)(=O)=O)cc(C)cc12 |r|
Show InChI InChI=1S/C22H29N5O3S/c1-14(2)25-22(28)17-7-6-8-18(11-17)27-21-10-15(3)9-20(19(21)13-24-27)23-12-16(4)26-31(5,29)30/h6-11,13-14,16,23,26H,12H2,1-5H3,(H,25,28)/t16-/m0/s1
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n/an/a 200n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417897
PNG
(CHEMBL1668087)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1cccc(c1)C(=O)NCC(N)=O)NS(=O)(=O)C1CC1 |r|
Show InChI InChI=1S/C23H28N6O4S/c1-14-8-20(25-11-15(2)28-34(32,33)18-6-7-18)19-12-27-29(21(19)9-14)17-5-3-4-16(10-17)23(31)26-13-22(24)30/h3-5,8-10,12,15,18,25,28H,6-7,11,13H2,1-2H3,(H2,24,30)(H,26,31)/t15-/m0/s1
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n/an/a 200n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at GR in human A549 cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activity

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417892
PNG
(CHEMBL1668082)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1cccc(c1)N1CCCC(CO)C1)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C32H41N5O3S/c1-21-12-23(3)32(24(4)13-21)41(39,40)35-25(5)17-33-30-14-22(2)15-31-29(30)18-34-37(31)28-10-6-9-27(16-28)36-11-7-8-26(19-36)20-38/h6,9-10,12-16,18,25-26,33,35,38H,7-8,11,17,19-20H2,1-5H3/t25-,26?/m0/s1
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n/an/a 251n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at GR in human A549 cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activity

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417892
PNG
(CHEMBL1668082)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1cccc(c1)N1CCCC(CO)C1)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C32H41N5O3S/c1-21-12-23(3)32(24(4)13-21)41(39,40)35-25(5)17-33-30-14-22(2)15-31-29(30)18-34-37(31)28-10-6-9-27(16-28)36-11-7-8-26(19-36)20-38/h6,9-10,12-16,18,25-26,33,35,38H,7-8,11,17,19-20H2,1-5H3/t25-,26?/m0/s1
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n/an/a 251n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at GR in human A549 cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activity

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417881
PNG
(CHEMBL1668071)
Show SMILES CNc1ccc(cc1)-n1ncc2c(NC[C@H](C)NS(=O)(=O)c3c(C)cc(C)cc3C)cc(C)cc12 |r|
Show InChI InChI=1S/C27H33N5O2S/c1-17-11-19(3)27(20(4)12-17)35(33,34)31-21(5)15-29-25-13-18(2)14-26-24(25)16-30-32(26)23-9-7-22(28-6)8-10-23/h7-14,16,21,28-29,31H,15H2,1-6H3/t21-/m0/s1
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n/an/a 251n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at GR in human A549 cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activity

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417899
PNG
(CHEMBL1668092)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1cccc(c1)C(=O)N1CCCC(CO)C1)NS(=O)(=O)C1CC1 |r|
Show InChI InChI=1S/C27H35N5O4S/c1-18-11-25(28-14-19(2)30-37(35,36)23-8-9-23)24-15-29-32(26(24)12-18)22-7-3-6-21(13-22)27(34)31-10-4-5-20(16-31)17-33/h3,6-7,11-13,15,19-20,23,28,30,33H,4-5,8-10,14,16-17H2,1-2H3/t19-,20?/m0/s1
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n/an/a 251n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417892
PNG
(CHEMBL1668082)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1cccc(c1)N1CCCC(CO)C1)NS(=O)(=O)c1c(C)cc(C)cc1C |r|
Show InChI InChI=1S/C32H41N5O3S/c1-21-12-23(3)32(24(4)13-21)41(39,40)35-25(5)17-33-30-14-22(2)15-31-29(30)18-34-37(31)28-10-6-9-27(16-28)36-11-7-8-26(19-36)20-38/h6,9-10,12-16,18,25-26,33,35,38H,7-8,11,17,19-20H2,1-5H3/t25-,26?/m0/s1
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n/an/a 630n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at GR in human A549 cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activity

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417874
PNG
(CHEMBL1668091)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1cccc(c1)C(=O)N1CCC[C@H]1C(N)=O)NS(=O)(=O)C1CC1 |r|
Show InChI InChI=1S/C26H32N6O4S/c1-16-11-22(28-14-17(2)30-37(35,36)20-8-9-20)21-15-29-32(24(21)12-16)19-6-3-5-18(13-19)26(34)31-10-4-7-23(31)25(27)33/h3,5-6,11-13,15,17,20,23,28,30H,4,7-10,14H2,1-2H3,(H2,27,33)/t17-,23-/m0/s1
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n/an/a 794n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417893
PNG
(CHEMBL1668083)
Show SMILES CC(C)NC(=O)c1cccc(c1)-n1ncc2c(NC[C@H](C)NS(C)(=O)=O)cc(C)cc12 |r|
Show InChI InChI=1S/C22H29N5O3S/c1-14(2)25-22(28)17-7-6-8-18(11-17)27-21-10-15(3)9-20(19(21)13-24-27)23-12-16(4)26-31(5,29)30/h6-11,13-14,16,23,26H,12H2,1-5H3,(H,25,28)/t16-/m0/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at GR in human A549 cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activity

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417874
PNG
(CHEMBL1668091)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1cccc(c1)C(=O)N1CCC[C@H]1C(N)=O)NS(=O)(=O)C1CC1 |r|
Show InChI InChI=1S/C26H32N6O4S/c1-16-11-22(28-14-17(2)30-37(35,36)20-8-9-20)21-15-29-32(24(21)12-16)19-6-3-5-18(13-19)26(34)31-10-4-7-23(31)25(27)33/h3,5-6,11-13,15,17,20,23,28,30H,4,7-10,14H2,1-2H3,(H2,27,33)/t17-,23-/m0/s1
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n/an/a 3.98E+3n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at GR in human A549 cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activity

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50417899
PNG
(CHEMBL1668092)
Show SMILES C[C@@H](CNc1cc(C)cc2n(ncc12)-c1cccc(c1)C(=O)N1CCCC(CO)C1)NS(=O)(=O)C1CC1 |r|
Show InChI InChI=1S/C27H35N5O4S/c1-18-11-25(28-14-19(2)30-37(35,36)23-8-9-23)24-15-29-32(26(24)12-18)22-7-3-6-21(13-22)27(34)31-10-4-5-20(16-31)17-33/h3,6-7,11-13,15,19-20,23,28,30,33H,4-5,8-10,14,16-17H2,1-2H3/t19-,20?/m0/s1
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n/an/a>6.31E+3n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Center

Curated by ChEMBL


Assay Description
Agonist activity at GR in human A549 cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activity

Bioorg Med Chem Lett 21: 1126-33 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.121
BindingDB Entry DOI: 10.7270/Q2571D8H
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%