Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Extracellular calcium-sensing receptor (Homo sapiens (Human)) | BDBM50339341 ((5R)-(-)-N-[1-Ethyl-1-(4-methylphenyl)propyl]-7,7-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assay | J Med Chem 54: 1430-40 (2011) Article DOI: 10.1021/jm101452x BindingDB Entry DOI: 10.7270/Q2K35TZ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Extracellular calcium-sensing receptor (Homo sapiens (Human)) | BDBM50339329 (CHEMBL1689815 | N-(1-Ethyl-1-phenylpropyl)-7,7-dim...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assay | J Med Chem 54: 1430-40 (2011) Article DOI: 10.1021/jm101452x BindingDB Entry DOI: 10.7270/Q2K35TZ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Extracellular calcium-sensing receptor (Homo sapiens (Human)) | BDBM50339323 (7,7-Dimethyl-N-{1-methyl-1-[4-(trifluoromethyl)phe...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assay | J Med Chem 54: 1430-40 (2011) Article DOI: 10.1021/jm101452x BindingDB Entry DOI: 10.7270/Q2K35TZ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Extracellular calcium-sensing receptor (Homo sapiens (Human)) | BDBM50339325 (7,7-Dimethyl-5-phenyl-N-{1-propyl-1-[4-(trifluorom...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assay | J Med Chem 54: 1430-40 (2011) Article DOI: 10.1021/jm101452x BindingDB Entry DOI: 10.7270/Q2K35TZ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Extracellular calcium-sensing receptor (Homo sapiens (Human)) | BDBM50339341 ((5R)-(-)-N-[1-Ethyl-1-(4-methylphenyl)propyl]-7,7-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assay | J Med Chem 54: 1430-40 (2011) Article DOI: 10.1021/jm101452x BindingDB Entry DOI: 10.7270/Q2K35TZ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Extracellular calcium-sensing receptor (Homo sapiens (Human)) | BDBM50339320 (CHEMBL1688103 | Ethyl 4-(1-{[(7,7-Dimethyl-5-pheny...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assay | J Med Chem 54: 1430-40 (2011) Article DOI: 10.1021/jm101452x BindingDB Entry DOI: 10.7270/Q2K35TZ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Extracellular calcium-sensing receptor (Homo sapiens (Human)) | BDBM50339335 (CHEMBL1687946 | N-[1-Ethyl-1-(4-methylphenyl)propy...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assay | J Med Chem 54: 1430-40 (2011) Article DOI: 10.1021/jm101452x BindingDB Entry DOI: 10.7270/Q2K35TZ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Extracellular calcium-sensing receptor (Homo sapiens (Human)) | BDBM50339336 (CHEMBL1688087 | N-[1-Ethyl-1-(4-methoxyphenyl)prop...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 6.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assay | J Med Chem 54: 1430-40 (2011) Article DOI: 10.1021/jm101452x BindingDB Entry DOI: 10.7270/Q2K35TZ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Extracellular calcium-sensing receptor (Homo sapiens (Human)) | BDBM50339332 (CHEMBL1689818 | N-[1-Ethyl-1-(4-fluorophenyl)propy...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 7.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assay | J Med Chem 54: 1430-40 (2011) Article DOI: 10.1021/jm101452x BindingDB Entry DOI: 10.7270/Q2K35TZ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Extracellular calcium-sensing receptor (Homo sapiens (Human)) | BDBM50339330 (CHEMBL1689816 | N-[1-(4-Chlorophenyl)-1-ethylpropy...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 7.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assay | J Med Chem 54: 1430-40 (2011) Article DOI: 10.1021/jm101452x BindingDB Entry DOI: 10.7270/Q2K35TZ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Extracellular calcium-sensing receptor (Homo sapiens (Human)) | BDBM50339324 (CHEMBL1689810 | N-{1-Ethyl-1-[4-(trifluoromethyl)p...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 7.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assay | J Med Chem 54: 1430-40 (2011) Article DOI: 10.1021/jm101452x BindingDB Entry DOI: 10.7270/Q2K35TZ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Extracellular calcium-sensing receptor (Homo sapiens (Human)) | BDBM50339337 (CHEMBL1688088 | N-{1-[4-(Benzyloxy)phenyl]-1-ethyl...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 8.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assay | J Med Chem 54: 1430-40 (2011) Article DOI: 10.1021/jm101452x BindingDB Entry DOI: 10.7270/Q2K35TZ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Extracellular calcium-sensing receptor (Homo sapiens (Human)) | BDBM50331964 (CHEMBL1290328 | N-(1-Adamantyl)-7,7-dimethyl-5-phe...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assay | J Med Chem 54: 1430-40 (2011) Article DOI: 10.1021/jm101452x BindingDB Entry DOI: 10.7270/Q2K35TZ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Extracellular calcium-sensing receptor (Homo sapiens (Human)) | BDBM50339340 (CHEMBL1688092 | N-{1-Ethyl-1-[4-(2-oxobutoxy)pheny...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assay | J Med Chem 54: 1430-40 (2011) Article DOI: 10.1021/jm101452x BindingDB Entry DOI: 10.7270/Q2K35TZ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Extracellular calcium-sensing receptor (Homo sapiens (Human)) | BDBM50339334 (CHEMBL1688086 | N-[1-Ethyl-1-(2-fluorophenyl)propy...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assay | J Med Chem 54: 1430-40 (2011) Article DOI: 10.1021/jm101452x BindingDB Entry DOI: 10.7270/Q2K35TZ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Extracellular calcium-sensing receptor (Homo sapiens (Human)) | BDBM50339338 (4-(1-{[(7,7-Dimethyl-5-phenyl-4,5,6,7-tetrahydropy...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assay | J Med Chem 54: 1430-40 (2011) Article DOI: 10.1021/jm101452x BindingDB Entry DOI: 10.7270/Q2K35TZ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Extracellular calcium-sensing receptor (Homo sapiens (Human)) | BDBM50339331 (CHEMBL1689817 | N-[1-(3-Chlorophenyl)-1-ethylpropy...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assay | J Med Chem 54: 1430-40 (2011) Article DOI: 10.1021/jm101452x BindingDB Entry DOI: 10.7270/Q2K35TZ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Extracellular calcium-sensing receptor (Homo sapiens (Human)) | BDBM50339326 (CHEMBL1689812 | N-{1-Butyl-1-[4-(trifluoromethyl)p...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assay | J Med Chem 54: 1430-40 (2011) Article DOI: 10.1021/jm101452x BindingDB Entry DOI: 10.7270/Q2K35TZ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Extracellular calcium-sensing receptor (Homo sapiens (Human)) | BDBM50339333 (CHEMBL1688085 | N-[1-Ethyl-1-(3-fluorophenyl)propy...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assay | J Med Chem 54: 1430-40 (2011) Article DOI: 10.1021/jm101452x BindingDB Entry DOI: 10.7270/Q2K35TZ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Extracellular calcium-sensing receptor (Homo sapiens (Human)) | BDBM50339327 (CHEMBL1689813 | N-{1-Isopropyl-2-methyl-1-[4-(trif...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assay | J Med Chem 54: 1430-40 (2011) Article DOI: 10.1021/jm101452x BindingDB Entry DOI: 10.7270/Q2K35TZ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Extracellular calcium-sensing receptor (Homo sapiens (Human)) | BDBM50339342 ((5S)-(+)-N-[1-Ethyl-1-(4-methylphenyl)propyl]-7,7-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assay | J Med Chem 54: 1430-40 (2011) Article DOI: 10.1021/jm101452x BindingDB Entry DOI: 10.7270/Q2K35TZ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Extracellular calcium-sensing receptor (Homo sapiens (Human)) | BDBM50339339 (4-(1-{[(7,7-Dimethyl-5-phenyl-4,5,6,7-tetrahydropy...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assay | J Med Chem 54: 1430-40 (2011) Article DOI: 10.1021/jm101452x BindingDB Entry DOI: 10.7270/Q2K35TZ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Extracellular calcium-sensing receptor (Homo sapiens (Human)) | BDBM50331946 (CHEMBL1289345 | N-(1-Adamantyl)-5-phenyl-7-(triflu...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assay | J Med Chem 54: 1430-40 (2011) Article DOI: 10.1021/jm101452x BindingDB Entry DOI: 10.7270/Q2K35TZ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Extracellular calcium-sensing receptor (Homo sapiens (Human)) | BDBM50339328 (CHEMBL1689814 | N-{Dicyclohexyl[4-(trifluoromethyl...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assay | J Med Chem 54: 1430-40 (2011) Article DOI: 10.1021/jm101452x BindingDB Entry DOI: 10.7270/Q2K35TZ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Extracellular calcium-sensing receptor (Homo sapiens (Human)) | BDBM50339322 ((5S,7R)-N-benzhydryl-5-phenyl-7-(trifluoromethyl)-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assay | J Med Chem 54: 1430-40 (2011) Article DOI: 10.1021/jm101452x BindingDB Entry DOI: 10.7270/Q2K35TZ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Extracellular calcium-sensing receptor (Homo sapiens (Human)) | BDBM50339321 ((5S,7R)-5-phenyl-7-(trifluoromethyl)-N-(4-(trifluo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assay | J Med Chem 54: 1430-40 (2011) Article DOI: 10.1021/jm101452x BindingDB Entry DOI: 10.7270/Q2K35TZ9 | |||||||||||
More data for this Ligand-Target Pair |