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PubMed code 21310612

Compile data set for download or QSAR
Found 99 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50337912
PNG
(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)
Show SMILES CNC(C)C1(CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C19H25N/c1-15(20-2)19(12-6-3-7-13-19)18-11-10-16-8-4-5-9-17(16)14-18/h4-5,8-11,14-15,20H,3,6-7,12-13H2,1-2H3
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n/an/a 6n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50337912
PNG
(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)
Show SMILES CNC(C)C1(CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C19H25N/c1-15(20-2)19(12-6-3-7-13-19)18-11-10-16-8-4-5-9-17(16)14-18/h4-5,8-11,14-15,20H,3,6-7,12-13H2,1-2H3
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n/an/a 6n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50337911
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,N-dim...)
Show SMILES CC(N(C)C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H23Cl2N/c1-12(19(2)3)16(9-5-4-6-10-16)13-7-8-14(17)15(18)11-13/h7-8,11-12H,4-6,9-10H2,1-3H3
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n/an/a 7n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]norepinephrine reuptake at human human recombinant NET expressed in HEK293 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50337911
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,N-dim...)
Show SMILES CC(N(C)C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H23Cl2N/c1-12(19(2)3)16(9-5-4-6-10-16)13-7-8-14(17)15(18)11-13/h7-8,11-12H,4-6,9-10H2,1-3H3
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n/an/a 7n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]norepinephrine reuptake at human human recombinant NET expressed in HEK293 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50337916
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,3-dim...)
Show SMILES CNC(CC(C)C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C18H27Cl2N/c1-13(2)11-17(21-3)18(9-5-4-6-10-18)14-7-8-15(19)16(20)12-14/h7-8,12-13,17,21H,4-6,9-11H2,1-3H3
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n/an/a 9n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]dopamine reuptake at human human recombinant DAT expressed in COS-7 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50337911
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,N-dim...)
Show SMILES CC(N(C)C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H23Cl2N/c1-12(19(2)3)16(9-5-4-6-10-16)13-7-8-14(17)15(18)11-13/h7-8,11-12H,4-6,9-10H2,1-3H3
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n/an/a 10n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]norepinephrine reuptake at human human recombinant NET expressed in HEK293 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50337911
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,N-dim...)
Show SMILES CC(N(C)C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H23Cl2N/c1-12(19(2)3)16(9-5-4-6-10-16)13-7-8-14(17)15(18)11-13/h7-8,11-12H,4-6,9-10H2,1-3H3
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n/an/a 12n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50337911
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,N-dim...)
Show SMILES CC(N(C)C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H23Cl2N/c1-12(19(2)3)16(9-5-4-6-10-16)13-7-8-14(17)15(18)11-13/h7-8,11-12H,4-6,9-10H2,1-3H3
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n/an/a 15n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50337911
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,N-dim...)
Show SMILES CC(N(C)C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H23Cl2N/c1-12(19(2)3)16(9-5-4-6-10-16)13-7-8-14(17)15(18)11-13/h7-8,11-12H,4-6,9-10H2,1-3H3
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n/an/a 15n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50337913
PNG
((+/-)-N,N-dimethyl-1-(1-(naphthalen-2-yl)cyclohexy...)
Show SMILES CC(N(C)C)C1(CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C20H27N/c1-16(21(2)3)20(13-7-4-8-14-20)19-12-11-17-9-5-6-10-18(17)15-19/h5-6,9-12,15-16H,4,7-8,13-14H2,1-3H3
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n/an/a 21n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]norepinephrine reuptake at human human recombinant NET expressed in HEK293 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50337838
PNG
(1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methylmetha...)
Show SMILES CNCC1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H19Cl2N/c1-17-10-14(7-3-2-4-8-14)11-5-6-12(15)13(16)9-11/h5-6,9,17H,2-4,7-8,10H2,1H3
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n/an/a 21n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]dopamine reuptake at human human recombinant DAT expressed in COS-7 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50337912
PNG
(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)
Show SMILES CNC(C)C1(CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C19H25N/c1-15(20-2)19(12-6-3-7-13-19)18-11-10-16-8-4-5-9-17(16)14-18/h4-5,8-11,14-15,20H,3,6-7,12-13H2,1-2H3
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n/an/a 23n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]norepinephrine reuptake at human human recombinant NET expressed in HEK293 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50337912
PNG
(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)
Show SMILES CNC(C)C1(CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C19H25N/c1-15(20-2)19(12-6-3-7-13-19)18-11-10-16-8-4-5-9-17(16)14-18/h4-5,8-11,14-15,20H,3,6-7,12-13H2,1-2H3
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n/an/a 23n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]norepinephrine reuptake at human human recombinant NET expressed in HEK293 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50337913
PNG
((+/-)-N,N-dimethyl-1-(1-(naphthalen-2-yl)cyclohexy...)
Show SMILES CC(N(C)C)C1(CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C20H27N/c1-16(21(2)3)20(13-7-4-8-14-20)19-12-11-17-9-5-6-10-18(17)15-19/h5-6,9-12,15-16H,4,7-8,13-14H2,1-3H3
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n/an/a 28n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]dopamine reuptake at human human recombinant DAT expressed in COS-7 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50337914
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)propan-1...)
Show SMILES CCC(N)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H21Cl2N/c1-2-14(18)15(8-4-3-5-9-15)11-6-7-12(16)13(17)10-11/h6-7,10,14H,2-5,8-9,18H2,1H3
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n/an/a 29n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]dopamine reuptake at human human recombinant DAT expressed in COS-7 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50337843
PNG
(CHEMBL1683901 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)
Show SMILES CNCC1(CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C18H23N/c1-19-14-18(11-5-2-6-12-18)17-10-9-15-7-3-4-8-16(15)13-17/h3-4,7-10,13,19H,2,5-6,11-12,14H2,1H3
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n/an/a 34n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50337911
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,N-dim...)
Show SMILES CC(N(C)C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H23Cl2N/c1-12(19(2)3)16(9-5-4-6-10-16)13-7-8-14(17)15(18)11-13/h7-8,11-12H,4-6,9-10H2,1-3H3
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n/an/a 36n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]dopamine reuptake at human human recombinant DAT expressed in COS-7 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50337910
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...)
Show SMILES CNC(C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H21Cl2N/c1-11(18-2)15(8-4-3-5-9-15)12-6-7-13(16)14(17)10-12/h6-7,10-11,18H,3-5,8-9H2,1-2H3
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n/an/a 37n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]norepinephrine reuptake at human human recombinant NET expressed in HEK293 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50337910
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...)
Show SMILES CNC(C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H21Cl2N/c1-11(18-2)15(8-4-3-5-9-15)12-6-7-13(16)14(17)10-12/h6-7,10-11,18H,3-5,8-9H2,1-2H3
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n/an/a 37n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]norepinephrine reuptake at human human recombinant NET expressed in HEK293 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50337913
PNG
((+/-)-N,N-dimethyl-1-(1-(naphthalen-2-yl)cyclohexy...)
Show SMILES CC(N(C)C)C1(CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C20H27N/c1-16(21(2)3)20(13-7-4-8-14-20)19-12-11-17-9-5-6-10-18(17)15-19/h5-6,9-12,15-16H,4,7-8,13-14H2,1-3H3
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n/an/a 61n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]norepinephrine reuptake at human human recombinant NET expressed in HEK293 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50337913
PNG
((+/-)-N,N-dimethyl-1-(1-(naphthalen-2-yl)cyclohexy...)
Show SMILES CC(N(C)C)C1(CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C20H27N/c1-16(21(2)3)20(13-7-4-8-14-20)19-12-11-17-9-5-6-10-18(17)15-19/h5-6,9-12,15-16H,4,7-8,13-14H2,1-3H3
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n/an/a 61n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]norepinephrine reuptake at human human recombinant NET expressed in HEK293 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50337912
PNG
(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)
Show SMILES CNC(C)C1(CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C19H25N/c1-15(20-2)19(12-6-3-7-13-19)18-11-10-16-8-4-5-9-17(16)14-18/h4-5,8-11,14-15,20H,3,6-7,12-13H2,1-2H3
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n/an/a 63n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]dopamine reuptake at human human recombinant DAT expressed in COS-7 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50337913
PNG
((+/-)-N,N-dimethyl-1-(1-(naphthalen-2-yl)cyclohexy...)
Show SMILES CC(N(C)C)C1(CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C20H27N/c1-16(21(2)3)20(13-7-4-8-14-20)19-12-11-17-9-5-6-10-18(17)15-19/h5-6,9-12,15-16H,4,7-8,13-14H2,1-3H3
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n/an/a 63n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50337912
PNG
(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)
Show SMILES CNC(C)C1(CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C19H25N/c1-15(20-2)19(12-6-3-7-13-19)18-11-10-16-8-4-5-9-17(16)14-18/h4-5,8-11,14-15,20H,3,6-7,12-13H2,1-2H3
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n/an/a 63n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]dopamine reuptake at human human recombinant DAT expressed in COS-7 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50337911
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,N-dim...)
Show SMILES CC(N(C)C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H23Cl2N/c1-12(19(2)3)16(9-5-4-6-10-16)13-7-8-14(17)15(18)11-13/h7-8,11-12H,4-6,9-10H2,1-3H3
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n/an/a 64n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]dopamine reuptake at human human recombinant DAT expressed in COS-7 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50337911
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,N-dim...)
Show SMILES CC(N(C)C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H23Cl2N/c1-12(19(2)3)16(9-5-4-6-10-16)13-7-8-14(17)15(18)11-13/h7-8,11-12H,4-6,9-10H2,1-3H3
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n/an/a 64n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]dopamine reuptake at human human recombinant DAT expressed in COS-7 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50337910
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...)
Show SMILES CNC(C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H21Cl2N/c1-11(18-2)15(8-4-3-5-9-15)12-6-7-13(16)14(17)10-12/h6-7,10-11,18H,3-5,8-9H2,1-2H3
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n/an/a 65n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50337910
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...)
Show SMILES CNC(C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H21Cl2N/c1-11(18-2)15(8-4-3-5-9-15)12-6-7-13(16)14(17)10-12/h6-7,10-11,18H,3-5,8-9H2,1-2H3
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n/an/a 65n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50337909
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)ethanami...)
Show SMILES CC(N)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H19Cl2N/c1-10(17)14(7-3-2-4-8-14)11-5-6-12(15)13(16)9-11/h5-6,9-10H,2-4,7-8,17H2,1H3
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n/an/a 69n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]dopamine reuptake at human human recombinant DAT expressed in COS-7 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50337909
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)ethanami...)
Show SMILES CC(N)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H19Cl2N/c1-10(17)14(7-3-2-4-8-14)11-5-6-12(15)13(16)9-11/h5-6,9-10H,2-4,7-8,17H2,1H3
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n/an/a 69n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]dopamine reuptake at human human recombinant DAT expressed in COS-7 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50337913
PNG
((+/-)-N,N-dimethyl-1-(1-(naphthalen-2-yl)cyclohexy...)
Show SMILES CC(N(C)C)C1(CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C20H27N/c1-16(21(2)3)20(13-7-4-8-14-20)19-12-11-17-9-5-6-10-18(17)15-19/h5-6,9-12,15-16H,4,7-8,13-14H2,1-3H3
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n/an/a 72n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]dopamine reuptake at human human recombinant DAT expressed in COS-7 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50337913
PNG
((+/-)-N,N-dimethyl-1-(1-(naphthalen-2-yl)cyclohexy...)
Show SMILES CC(N(C)C)C1(CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C20H27N/c1-16(21(2)3)20(13-7-4-8-14-20)19-12-11-17-9-5-6-10-18(17)15-19/h5-6,9-12,15-16H,4,7-8,13-14H2,1-3H3
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n/an/a 72n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]dopamine reuptake at human human recombinant DAT expressed in COS-7 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50337838
PNG
(1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methylmetha...)
Show SMILES CNCC1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H19Cl2N/c1-17-10-14(7-3-2-4-8-14)11-5-6-12(15)13(16)9-11/h5-6,9,17H,2-4,7-8,10H2,1H3
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n/an/a 85n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]norepinephrine reuptake at human human recombinant NET expressed in HEK293 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50337910
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...)
Show SMILES CNC(C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H21Cl2N/c1-11(18-2)15(8-4-3-5-9-15)12-6-7-13(16)14(17)10-12/h6-7,10-11,18H,3-5,8-9H2,1-2H3
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n/an/a 86n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]dopamine reuptake at human human recombinant DAT expressed in COS-7 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50337910
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...)
Show SMILES CNC(C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H21Cl2N/c1-11(18-2)15(8-4-3-5-9-15)12-6-7-13(16)14(17)10-12/h6-7,10-11,18H,3-5,8-9H2,1-2H3
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n/an/a 86n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]dopamine reuptake at human human recombinant DAT expressed in COS-7 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50337843
PNG
(CHEMBL1683901 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)
Show SMILES CNCC1(CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C18H23N/c1-19-14-18(11-5-2-6-12-18)17-10-9-15-7-3-4-8-16(15)13-17/h3-4,7-10,13,19H,2,5-6,11-12,14H2,1H3
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n/an/a 90n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]dopamine reuptake at human human recombinant DAT expressed in COS-7 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50337904
PNG
((+/-)-1-(1-(naphthalen-2-yl)cyclohexyl)ethanamine ...)
Show SMILES CC(N)C1(CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C18H23N/c1-14(19)18(11-5-2-6-12-18)17-10-9-15-7-3-4-8-16(15)13-17/h3-4,7-10,13-14H,2,5-6,11-12,19H2,1H3
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n/an/a 110n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]dopamine reuptake at human human recombinant DAT expressed in COS-7 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50337905
PNG
(1-(1-(4-(trifluoromethoxy)phenyl)cyclohexyl)ethana...)
Show SMILES CC(N)C1(CCCCC1)c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C15H20F3NO/c1-11(19)14(9-3-2-4-10-14)12-5-7-13(8-6-12)20-15(16,17)18/h5-8,11H,2-4,9-10,19H2,1H3
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n/an/a 110n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50337904
PNG
((+/-)-1-(1-(naphthalen-2-yl)cyclohexyl)ethanamine ...)
Show SMILES CC(N)C1(CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C18H23N/c1-14(19)18(11-5-2-6-12-18)17-10-9-15-7-3-4-8-16(15)13-17/h3-4,7-10,13-14H,2,5-6,11-12,19H2,1H3
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n/an/a 120n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]dopamine reuptake at human human recombinant DAT expressed in COS-7 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50337904
PNG
((+/-)-1-(1-(naphthalen-2-yl)cyclohexyl)ethanamine ...)
Show SMILES CC(N)C1(CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C18H23N/c1-14(19)18(11-5-2-6-12-18)17-10-9-15-7-3-4-8-16(15)13-17/h3-4,7-10,13-14H,2,5-6,11-12,19H2,1H3
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n/an/a 120n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]dopamine reuptake at human human recombinant DAT expressed in COS-7 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50337914
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)propan-1...)
Show SMILES CCC(N)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H21Cl2N/c1-2-14(18)15(8-4-3-5-9-15)11-6-7-12(16)13(17)10-11/h6-7,10,14H,2-5,8-9,18H2,1H3
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Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]norepinephrine reuptake at human human recombinant NET expressed in HEK293 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50337910
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...)
Show SMILES CNC(C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H21Cl2N/c1-11(18-2)15(8-4-3-5-9-15)12-6-7-13(16)14(17)10-12/h6-7,10-11,18H,3-5,8-9H2,1-2H3
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Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50337838
PNG
(1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methylmetha...)
Show SMILES CNCC1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H19Cl2N/c1-17-10-14(7-3-2-4-8-14)11-5-6-12(15)13(16)9-11/h5-6,9,17H,2-4,7-8,10H2,1H3
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Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50337909
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)ethanami...)
Show SMILES CC(N)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H19Cl2N/c1-10(17)14(7-3-2-4-8-14)11-5-6-12(15)13(16)9-11/h5-6,9-10H,2-4,7-8,17H2,1H3
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Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]norepinephrine reuptake at human human recombinant NET expressed in HEK293 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50337909
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)ethanami...)
Show SMILES CC(N)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H19Cl2N/c1-10(17)14(7-3-2-4-8-14)11-5-6-12(15)13(16)9-11/h5-6,9-10H,2-4,7-8,17H2,1H3
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Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]dopamine reuptake at human human recombinant DAT expressed in COS-7 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50337904
PNG
((+/-)-1-(1-(naphthalen-2-yl)cyclohexyl)ethanamine ...)
Show SMILES CC(N)C1(CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C18H23N/c1-14(19)18(11-5-2-6-12-18)17-10-9-15-7-3-4-8-16(15)13-17/h3-4,7-10,13-14H,2,5-6,11-12,19H2,1H3
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Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50337908
PNG
(1-(1-(biphenyl-4-yl)cyclohexyl)ethanamine | CHEMBL...)
Show SMILES CC(N)C1(CCCCC1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C20H25N/c1-16(21)20(14-6-3-7-15-20)19-12-10-18(11-13-19)17-8-4-2-5-9-17/h2,4-5,8-13,16H,3,6-7,14-15,21H2,1H3
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Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50337843
PNG
(CHEMBL1683901 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)
Show SMILES CNCC1(CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C18H23N/c1-19-14-18(11-5-2-6-12-18)17-10-9-15-7-3-4-8-16(15)13-17/h3-4,7-10,13,19H,2,5-6,11-12,14H2,1H3
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Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]norepinephrine reuptake at human human recombinant NET expressed in HEK293 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50337910
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...)
Show SMILES CNC(C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H21Cl2N/c1-11(18-2)15(8-4-3-5-9-15)12-6-7-13(16)14(17)10-12/h6-7,10-11,18H,3-5,8-9H2,1-2H3
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Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]dopamine reuptake at human human recombinant DAT expressed in COS-7 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50337909
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)ethanami...)
Show SMILES CC(N)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H19Cl2N/c1-10(17)14(7-3-2-4-8-14)11-5-6-12(15)13(16)9-11/h5-6,9-10H,2-4,7-8,17H2,1H3
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Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]norepinephrine reuptake at human human recombinant NET expressed in HEK293 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50337909
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)ethanami...)
Show SMILES CC(N)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H19Cl2N/c1-10(17)14(7-3-2-4-8-14)11-5-6-12(15)13(16)9-11/h5-6,9-10H,2-4,7-8,17H2,1H3
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Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]norepinephrine reuptake at human human recombinant NET expressed in HEK293 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50337904
PNG
((+/-)-1-(1-(naphthalen-2-yl)cyclohexyl)ethanamine ...)
Show SMILES CC(N)C1(CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C18H23N/c1-14(19)18(11-5-2-6-12-18)17-10-9-15-7-3-4-8-16(15)13-17/h3-4,7-10,13-14H,2,5-6,11-12,19H2,1H3
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Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]norepinephrine reuptake at human human recombinant NET expressed in HEK293 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50337915
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-3-methy...)
Show SMILES CC(C)CC(N)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H25Cl2N/c1-12(2)10-16(20)17(8-4-3-5-9-17)13-6-7-14(18)15(19)11-13/h6-7,11-12,16H,3-5,8-10,20H2,1-2H3
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Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50337904
PNG
((+/-)-1-(1-(naphthalen-2-yl)cyclohexyl)ethanamine ...)
Show SMILES CC(N)C1(CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C18H23N/c1-14(19)18(11-5-2-6-12-18)17-10-9-15-7-3-4-8-16(15)13-17/h3-4,7-10,13-14H,2,5-6,11-12,19H2,1H3
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Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]norepinephrine reuptake at human human recombinant NET expressed in HEK293 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50337902
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,N,3-t...)
Show SMILES CC(C)CC(N(C)C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H29Cl2N/c1-14(2)12-18(22(3)4)19(10-6-5-7-11-19)15-8-9-16(20)17(21)13-15/h8-9,13-14,18H,5-7,10-12H2,1-4H3
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Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]dopamine reuptake at human human recombinant DAT expressed in COS-7 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50337909
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)ethanami...)
Show SMILES CC(N)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H19Cl2N/c1-10(17)14(7-3-2-4-8-14)11-5-6-12(15)13(16)9-11/h5-6,9-10H,2-4,7-8,17H2,1H3
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Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50337910
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...)
Show SMILES CNC(C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H21Cl2N/c1-11(18-2)15(8-4-3-5-9-15)12-6-7-13(16)14(17)10-12/h6-7,10-11,18H,3-5,8-9H2,1-2H3
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Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]norepinephrine reuptake at human human recombinant NET expressed in HEK293 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50337904
PNG
((+/-)-1-(1-(naphthalen-2-yl)cyclohexyl)ethanamine ...)
Show SMILES CC(N)C1(CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C18H23N/c1-14(19)18(11-5-2-6-12-18)17-10-9-15-7-3-4-8-16(15)13-17/h3-4,7-10,13-14H,2,5-6,11-12,19H2,1H3
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Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50337904
PNG
((+/-)-1-(1-(naphthalen-2-yl)cyclohexyl)ethanamine ...)
Show SMILES CC(N)C1(CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C18H23N/c1-14(19)18(11-5-2-6-12-18)17-10-9-15-7-3-4-8-16(15)13-17/h3-4,7-10,13-14H,2,5-6,11-12,19H2,1H3
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Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50337904
PNG
((+/-)-1-(1-(naphthalen-2-yl)cyclohexyl)ethanamine ...)
Show SMILES CC(N)C1(CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C18H23N/c1-14(19)18(11-5-2-6-12-18)17-10-9-15-7-3-4-8-16(15)13-17/h3-4,7-10,13-14H,2,5-6,11-12,19H2,1H3
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Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]norepinephrine reuptake at human human recombinant NET expressed in HEK293 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50337908
PNG
(1-(1-(biphenyl-4-yl)cyclohexyl)ethanamine | CHEMBL...)
Show SMILES CC(N)C1(CCCCC1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C20H25N/c1-16(21)20(14-6-3-7-15-20)19-12-10-18(11-13-19)17-8-4-2-5-9-17/h2,4-5,8-13,16H,3,6-7,14-15,21H2,1H3
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Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]dopamine reuptake at human human recombinant DAT expressed in COS-7 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50337909
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)ethanami...)
Show SMILES CC(N)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H19Cl2N/c1-10(17)14(7-3-2-4-8-14)11-5-6-12(15)13(16)9-11/h5-6,9-10H,2-4,7-8,17H2,1H3
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n/an/a 540n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50337909
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)ethanami...)
Show SMILES CC(N)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H19Cl2N/c1-10(17)14(7-3-2-4-8-14)11-5-6-12(15)13(16)9-11/h5-6,9-10H,2-4,7-8,17H2,1H3
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n/an/a 540n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50337914
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)propan-1...)
Show SMILES CCC(N)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H21Cl2N/c1-2-14(18)15(8-4-3-5-9-15)11-6-7-12(16)13(17)10-11/h6-7,10,14H,2-5,8-9,18H2,1H3
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n/an/a 660n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50337915
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-3-methy...)
Show SMILES CC(C)CC(N)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H25Cl2N/c1-12(2)10-16(20)17(8-4-3-5-9-17)13-6-7-14(18)15(19)11-13/h6-7,11-12,16H,3-5,8-10,20H2,1-2H3
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n/an/a 890n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]norepinephrine reuptake at human human recombinant NET expressed in HEK293 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50337916
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,3-dim...)
Show SMILES CNC(CC(C)C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C18H27Cl2N/c1-13(2)11-17(21-3)18(9-5-4-6-10-18)14-7-8-15(19)16(20)12-14/h7-8,12-13,17,21H,4-6,9-11H2,1-3H3
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n/an/a 960n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]norepinephrine reuptake at human human recombinant NET expressed in HEK293 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50337907
PNG
(1-(1-(thiophen-2-yl)cyclohexyl)ethanamine | CHEMBL...)
Show SMILES CC(N)C1(CCCCC1)c1cccs1
Show InChI InChI=1S/C12H19NS/c1-10(13)12(7-3-2-4-8-12)11-6-5-9-14-11/h5-6,9-10H,2-4,7-8,13H2,1H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]dopamine reuptake at human human recombinant DAT expressed in COS-7 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50337906
PNG
(1-(1-(4-tert-butoxyphenyl)cyclohexyl)ethanamine | ...)
Show SMILES CC(N)C1(CCCCC1)c1ccc(OC(C)(C)C)cc1
Show InChI InChI=1S/C18H29NO/c1-14(19)18(12-6-5-7-13-18)15-8-10-16(11-9-15)20-17(2,3)4/h8-11,14H,5-7,12-13,19H2,1-4H3
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n/an/a 1.52E+3n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]dopamine reuptake at human human recombinant DAT expressed in COS-7 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50337903
PNG
(1-(1-(naphthalen-1-yl)cyclohexyl)ethanamine | CHEM...)
Show SMILES CC(N)C1(CCCCC1)c1cccc2ccccc12
Show InChI InChI=1S/C18H23N/c1-14(19)18(12-5-2-6-13-18)17-11-7-9-15-8-3-4-10-16(15)17/h3-4,7-11,14H,2,5-6,12-13,19H2,1H3
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n/an/a 1.70E+3n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50337905
PNG
(1-(1-(4-(trifluoromethoxy)phenyl)cyclohexyl)ethana...)
Show SMILES CC(N)C1(CCCCC1)c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C15H20F3NO/c1-11(19)14(9-3-2-4-10-14)12-5-7-13(8-6-12)20-15(16,17)18/h5-8,11H,2-4,9-10,19H2,1H3
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n/an/a 2.30E+3n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]dopamine reuptake at human human recombinant DAT expressed in COS-7 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50337905
PNG
(1-(1-(4-(trifluoromethoxy)phenyl)cyclohexyl)ethana...)
Show SMILES CC(N)C1(CCCCC1)c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C15H20F3NO/c1-11(19)14(9-3-2-4-10-14)12-5-7-13(8-6-12)20-15(16,17)18/h5-8,11H,2-4,9-10,19H2,1H3
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n/an/a 3.20E+3n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]norepinephrine reuptake at human human recombinant NET expressed in HEK293 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50337903
PNG
(1-(1-(naphthalen-1-yl)cyclohexyl)ethanamine | CHEM...)
Show SMILES CC(N)C1(CCCCC1)c1cccc2ccccc12
Show InChI InChI=1S/C18H23N/c1-14(19)18(12-5-2-6-13-18)17-11-7-9-15-8-3-4-10-16(15)17/h3-4,7-11,14H,2,5-6,12-13,19H2,1H3
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n/an/a 4.00E+3n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]norepinephrine reuptake at human human recombinant NET expressed in HEK293 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50337903
PNG
(1-(1-(naphthalen-1-yl)cyclohexyl)ethanamine | CHEM...)
Show SMILES CC(N)C1(CCCCC1)c1cccc2ccccc12
Show InChI InChI=1S/C18H23N/c1-14(19)18(12-5-2-6-13-18)17-11-7-9-15-8-3-4-10-16(15)17/h3-4,7-11,14H,2,5-6,12-13,19H2,1H3
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n/an/a 4.00E+3n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]dopamine reuptake at human human recombinant DAT expressed in COS-7 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50337908
PNG
(1-(1-(biphenyl-4-yl)cyclohexyl)ethanamine | CHEMBL...)
Show SMILES CC(N)C1(CCCCC1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C20H25N/c1-16(21)20(14-6-3-7-15-20)19-12-10-18(11-13-19)17-8-4-2-5-9-17/h2,4-5,8-13,16H,3,6-7,14-15,21H2,1H3
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n/an/a 4.00E+3n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]norepinephrine reuptake at human human recombinant NET expressed in HEK293 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50337913
PNG
((+/-)-N,N-dimethyl-1-(1-(naphthalen-2-yl)cyclohexy...)
Show SMILES CC(N(C)C)C1(CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C20H27N/c1-16(21(2)3)20(13-7-4-8-14-20)19-12-11-17-9-5-6-10-18(17)15-19/h5-6,9-12,15-16H,4,7-8,13-14H2,1-3H3
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n/an/a 4.30E+3n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ERG

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50337913
PNG
((+/-)-N,N-dimethyl-1-(1-(naphthalen-2-yl)cyclohexy...)
Show SMILES CC(N(C)C)C1(CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C20H27N/c1-16(21(2)3)20(13-7-4-8-14-20)19-12-11-17-9-5-6-10-18(17)15-19/h5-6,9-12,15-16H,4,7-8,13-14H2,1-3H3
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n/an/a 4.30E+3n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ERG

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (Human))		BDBM50337913
PNG
((+/-)-N,N-dimethyl-1-(1-(naphthalen-2-yl)cyclohexy...)
Show SMILES CC(N(C)C)C1(CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C20H27N/c1-16(21(2)3)20(13-7-4-8-14-20)19-12-11-17-9-5-6-10-18(17)15-19/h5-6,9-12,15-16H,4,7-8,13-14H2,1-3H3
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n/an/a>5.00E+3n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of CYP2C9

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Cytochrome P450 2C19


(Homo sapiens (Human))		BDBM50337913
PNG
((+/-)-N,N-dimethyl-1-(1-(naphthalen-2-yl)cyclohexy...)
Show SMILES CC(N(C)C)C1(CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C20H27N/c1-16(21(2)3)20(13-7-4-8-14-20)19-12-11-17-9-5-6-10-18(17)15-19/h5-6,9-12,15-16H,4,7-8,13-14H2,1-3H3
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n/an/a>5.00E+3n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of CYP2C19

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50337906
PNG
(1-(1-(4-tert-butoxyphenyl)cyclohexyl)ethanamine | ...)
Show SMILES CC(N)C1(CCCCC1)c1ccc(OC(C)(C)C)cc1
Show InChI InChI=1S/C18H29NO/c1-14(19)18(12-6-5-7-13-18)15-8-10-16(11-9-15)20-17(2,3)4/h8-11,14H,5-7,12-13,19H2,1-4H3
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n/an/a 5.00E+3n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]norepinephrine reuptake at human human recombinant NET expressed in HEK293 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Cytochrome P450 2D6


(Homo sapiens (Human))		BDBM50337913
PNG
((+/-)-N,N-dimethyl-1-(1-(naphthalen-2-yl)cyclohexy...)
Show SMILES CC(N(C)C)C1(CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C20H27N/c1-16(21(2)3)20(13-7-4-8-14-20)19-12-11-17-9-5-6-10-18(17)15-19/h5-6,9-12,15-16H,4,7-8,13-14H2,1-3H3
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n/an/a>5.00E+3n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of CYP2D6

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Cytochrome P450 3A4


(Homo sapiens (Human))		BDBM50337913
PNG
((+/-)-N,N-dimethyl-1-(1-(naphthalen-2-yl)cyclohexy...)
Show SMILES CC(N(C)C)C1(CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C20H27N/c1-16(21(2)3)20(13-7-4-8-14-20)19-12-11-17-9-5-6-10-18(17)15-19/h5-6,9-12,15-16H,4,7-8,13-14H2,1-3H3
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n/an/a>5.00E+3n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of CYP3A4

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50337916
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,3-dim...)
Show SMILES CNC(CC(C)C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C18H27Cl2N/c1-13(2)11-17(21-3)18(9-5-4-6-10-18)14-7-8-15(19)16(20)12-14/h7-8,12-13,17,21H,4-6,9-11H2,1-3H3
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n/an/a 5.90E+3n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50337906
PNG
(1-(1-(4-tert-butoxyphenyl)cyclohexyl)ethanamine | ...)
Show SMILES CC(N)C1(CCCCC1)c1ccc(OC(C)(C)C)cc1
Show InChI InChI=1S/C18H29NO/c1-14(19)18(12-6-5-7-13-18)15-8-10-16(11-9-15)20-17(2,3)4/h8-11,14H,5-7,12-13,19H2,1-4H3
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n/an/a 7.10E+3n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Cytochrome P450 2D6


(Homo sapiens (Human))		BDBM50337910
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...)
Show SMILES CNC(C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H21Cl2N/c1-11(18-2)15(8-4-3-5-9-15)12-6-7-13(16)14(17)10-12/h6-7,10-11,18H,3-5,8-9H2,1-2H3
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n/an/a 8.50E+3n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of CYP2D6

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50337907
PNG
(1-(1-(thiophen-2-yl)cyclohexyl)ethanamine | CHEMBL...)
Show SMILES CC(N)C1(CCCCC1)c1cccs1
Show InChI InChI=1S/C12H19NS/c1-10(13)12(7-3-2-4-8-12)11-6-5-9-14-11/h5-6,9-10H,2-4,7-8,13H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]norepinephrine reuptake at human human recombinant NET expressed in HEK293 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50337902
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,N,3-t...)
Show SMILES CC(C)CC(N(C)C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H29Cl2N/c1-14(2)12-18(22(3)4)19(10-6-5-7-11-19)15-8-9-16(20)17(21)13-15/h8-9,13-14,18H,5-7,10-12H2,1-4H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50337907
PNG
(1-(1-(thiophen-2-yl)cyclohexyl)ethanamine | CHEMBL...)
Show SMILES CC(N)C1(CCCCC1)c1cccs1
Show InChI InChI=1S/C12H19NS/c1-10(13)12(7-3-2-4-8-12)11-6-5-9-14-11/h5-6,9-10H,2-4,7-8,13H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50337902
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,N,3-t...)
Show SMILES CC(C)CC(N(C)C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H29Cl2N/c1-14(2)12-18(22(3)4)19(10-6-5-7-11-19)15-8-9-16(20)17(21)13-15/h8-9,13-14,18H,5-7,10-12H2,1-4H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]norepinephrine reuptake at human human recombinant NET expressed in HEK293 cells by scintillation counting

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50337910
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...)
Show SMILES CNC(C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H21Cl2N/c1-11(18-2)15(8-4-3-5-9-15)12-6-7-13(16)14(17)10-12/h6-7,10-11,18H,3-5,8-9H2,1-2H3
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n/an/a 2.30E+4n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ERG

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50337910
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...)
Show SMILES CNC(C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H21Cl2N/c1-11(18-2)15(8-4-3-5-9-15)12-6-7-13(16)14(17)10-12/h6-7,10-11,18H,3-5,8-9H2,1-2H3
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n/an/a 2.30E+4n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ERG

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Cytochrome P450 3A4


(Homo sapiens (Human))		BDBM50337910
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...)
Show SMILES CNC(C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H21Cl2N/c1-11(18-2)15(8-4-3-5-9-15)12-6-7-13(16)14(17)10-12/h6-7,10-11,18H,3-5,8-9H2,1-2H3
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n/an/a>2.50E+4n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of CYP3A4

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (Human))		BDBM50337911
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,N-dim...)
Show SMILES CC(N(C)C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H23Cl2N/c1-12(19(2)3)16(9-5-4-6-10-16)13-7-8-14(17)15(18)11-13/h7-8,11-12H,4-6,9-10H2,1-3H3
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n/an/a>2.50E+4n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of CYP2C9

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (Human))		BDBM50337910
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...)
Show SMILES CNC(C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H21Cl2N/c1-11(18-2)15(8-4-3-5-9-15)12-6-7-13(16)14(17)10-12/h6-7,10-11,18H,3-5,8-9H2,1-2H3
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n/an/a>2.50E+4n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of CYP2C9

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Cytochrome P450 3A4


(Homo sapiens (Human))		BDBM50337911
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,N-dim...)
Show SMILES CC(N(C)C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H23Cl2N/c1-12(19(2)3)16(9-5-4-6-10-16)13-7-8-14(17)15(18)11-13/h7-8,11-12H,4-6,9-10H2,1-3H3
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n/an/a>2.50E+4n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of CYP3A4

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Cytochrome P450 2D6


(Homo sapiens (Human))		BDBM50337911
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,N-dim...)
Show SMILES CC(N(C)C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H23Cl2N/c1-12(19(2)3)16(9-5-4-6-10-16)13-7-8-14(17)15(18)11-13/h7-8,11-12H,4-6,9-10H2,1-3H3
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n/an/a>2.50E+4n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of CYP2D6

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Cytochrome P450 2C19


(Homo sapiens (Human))		BDBM50337911
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,N-dim...)
Show SMILES CC(N(C)C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H23Cl2N/c1-12(19(2)3)16(9-5-4-6-10-16)13-7-8-14(17)15(18)11-13/h7-8,11-12H,4-6,9-10H2,1-3H3
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n/an/a>2.50E+4n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of CYP2C19

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Cytochrome P450 2C19


(Homo sapiens (Human))		BDBM50337910
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...)
Show SMILES CNC(C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H21Cl2N/c1-11(18-2)15(8-4-3-5-9-15)12-6-7-13(16)14(17)10-12/h6-7,10-11,18H,3-5,8-9H2,1-2H3
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n/an/a>2.50E+4n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of CYP2C19

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50337911
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,N-dim...)
Show SMILES CC(N(C)C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H23Cl2N/c1-12(19(2)3)16(9-5-4-6-10-16)13-7-8-14(17)15(18)11-13/h7-8,11-12H,4-6,9-10H2,1-3H3
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n/an/a 4.00E+4n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ERG

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50337911
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,N-dim...)
Show SMILES CC(N(C)C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H23Cl2N/c1-12(19(2)3)16(9-5-4-6-10-16)13-7-8-14(17)15(18)11-13/h7-8,11-12H,4-6,9-10H2,1-3H3
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n/an/a 4.00E+4n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ERG

Bioorg Med Chem Lett 21: 1434-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.019
BindingDB Entry DOI: 10.7270/Q2CV4J2P
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%