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PubMed code 21316234

Compile data set for download or QSAR
Found 133 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50338292
PNG
(CHEMBL1682014 | N-(4-chloro-3-(1H-1,2,4-triazol-5-...)
Show SMILES Clc1csc(NC(=O)CN2C(=O)CCc3ccccc23)c1-c1nnc[nH]1
Show InChI InChI=1S/C17H14ClN5O2S/c18-11-8-26-17(15(11)16-19-9-20-22-16)21-13(24)7-23-12-4-2-1-3-10(12)5-6-14(23)25/h1-4,8-9H,5-7H2,(H,21,24)(H,19,20,22)
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n/an/a 4n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50338292
PNG
(CHEMBL1682014 | N-(4-chloro-3-(1H-1,2,4-triazol-5-...)
Show SMILES Clc1csc(NC(=O)CN2C(=O)CCc3ccccc23)c1-c1nnc[nH]1
Show InChI InChI=1S/C17H14ClN5O2S/c18-11-8-26-17(15(11)16-19-9-20-22-16)21-13(24)7-23-12-4-2-1-3-10(12)5-6-14(23)25/h1-4,8-9H,5-7H2,(H,21,24)(H,19,20,22)
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n/an/a 5n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50338293
PNG
(CHEMBL1682015 | N-(4-cyano-3-(1H-1,2,4-triazol-5-y...)
Show SMILES O=C(CN1C(=O)CCc2ccccc12)Nc1scc(C#N)c1-c1nnc[nH]1
Show InChI InChI=1S/C18H14N6O2S/c19-7-12-9-27-18(16(12)17-20-10-21-23-17)22-14(25)8-24-13-4-2-1-3-11(13)5-6-15(24)26/h1-4,9-10H,5-6,8H2,(H,22,25)(H,20,21,23)
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n/an/a 6n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50338264
PNG
(CHEMBL1682018 | N-(4-cyano-3-(1H-1,2,4-triazol-5-y...)
Show SMILES O=C(Cc1cccc2cnccc12)Nc1scc(C#N)c1-c1nnc[nH]1
Show InChI InChI=1S/C18H12N6OS/c19-7-13-9-26-18(16(13)17-21-10-22-24-17)23-15(25)6-11-2-1-3-12-8-20-5-4-14(11)12/h1-5,8-10H,6H2,(H,23,25)(H,21,22,24)
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n/an/a 7n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50338293
PNG
(CHEMBL1682015 | N-(4-cyano-3-(1H-1,2,4-triazol-5-y...)
Show SMILES O=C(CN1C(=O)CCc2ccccc12)Nc1scc(C#N)c1-c1nnc[nH]1
Show InChI InChI=1S/C18H14N6O2S/c19-7-12-9-27-18(16(12)17-20-10-21-23-17)22-14(25)8-24-13-4-2-1-3-11(13)5-6-15(24)26/h1-4,9-10H,5-6,8H2,(H,22,25)(H,20,21,23)
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n/an/a 8n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50338293
PNG
(CHEMBL1682015 | N-(4-cyano-3-(1H-1,2,4-triazol-5-y...)
Show SMILES O=C(CN1C(=O)CCc2ccccc12)Nc1scc(C#N)c1-c1nnc[nH]1
Show InChI InChI=1S/C18H14N6O2S/c19-7-12-9-27-18(16(12)17-20-10-21-23-17)22-14(25)8-24-13-4-2-1-3-11(13)5-6-15(24)26/h1-4,9-10H,5-6,8H2,(H,22,25)(H,20,21,23)
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n/an/a 9n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50338292
PNG
(CHEMBL1682014 | N-(4-chloro-3-(1H-1,2,4-triazol-5-...)
Show SMILES Clc1csc(NC(=O)CN2C(=O)CCc3ccccc23)c1-c1nnc[nH]1
Show InChI InChI=1S/C17H14ClN5O2S/c18-11-8-26-17(15(11)16-19-9-20-22-16)21-13(24)7-23-12-4-2-1-3-10(12)5-6-14(23)25/h1-4,8-9H,5-7H2,(H,21,24)(H,19,20,22)
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n/an/a 9n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50338264
PNG
(CHEMBL1682018 | N-(4-cyano-3-(1H-1,2,4-triazol-5-y...)
Show SMILES O=C(Cc1cccc2cnccc12)Nc1scc(C#N)c1-c1nnc[nH]1
Show InChI InChI=1S/C18H12N6OS/c19-7-13-9-26-18(16(13)17-21-10-22-24-17)23-15(25)6-11-2-1-3-12-8-20-5-4-14(11)12/h1-5,8-10H,6H2,(H,23,25)(H,21,22,24)
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n/an/a 11n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50338263
PNG
(CHEMBL1682017 | N-(4-chloro-3-(1H-1,2,4-triazol-5-...)
Show SMILES Clc1csc(NC(=O)Cc2cccc3cnccc23)c1-c1nnc[nH]1
Show InChI InChI=1S/C17H12ClN5OS/c18-13-8-25-17(15(13)16-20-9-21-23-16)22-14(24)6-10-2-1-3-11-7-19-5-4-12(10)11/h1-5,7-9H,6H2,(H,22,24)(H,20,21,23)
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n/an/a 11n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50338267
PNG
(CHEMBL1682021 | N-(4-cyano-3-(1H-1,2,4-triazol-5-y...)
Show SMILES O=C(Cc1cccc2ncccc12)Nc1scc(C#N)c1-c1nnc[nH]1
Show InChI InChI=1S/C18H12N6OS/c19-8-12-9-26-18(16(12)17-21-10-22-24-17)23-15(25)7-11-3-1-5-14-13(11)4-2-6-20-14/h1-6,9-10H,7H2,(H,23,25)(H,21,22,24)
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n/an/a 12n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50338267
PNG
(CHEMBL1682021 | N-(4-cyano-3-(1H-1,2,4-triazol-5-y...)
Show SMILES O=C(Cc1cccc2ncccc12)Nc1scc(C#N)c1-c1nnc[nH]1
Show InChI InChI=1S/C18H12N6OS/c19-8-12-9-26-18(16(12)17-21-10-22-24-17)23-15(25)7-11-3-1-5-14-13(11)4-2-6-20-14/h1-6,9-10H,7H2,(H,23,25)(H,21,22,24)
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n/an/a 12n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50338263
PNG
(CHEMBL1682017 | N-(4-chloro-3-(1H-1,2,4-triazol-5-...)
Show SMILES Clc1csc(NC(=O)Cc2cccc3cnccc23)c1-c1nnc[nH]1
Show InChI InChI=1S/C17H12ClN5OS/c18-13-8-25-17(15(13)16-20-9-21-23-16)22-14(24)6-10-2-1-3-11-7-19-5-4-12(10)11/h1-5,7-9H,6H2,(H,22,24)(H,20,21,23)
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n/an/a 14n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50338266
PNG
(CHEMBL1682020 | N-(4-chloro-3-(1H-1,2,4-triazol-5-...)
Show SMILES Clc1csc(NC(=O)Cc2cccc3ncccc23)c1-c1nnc[nH]1
Show InChI InChI=1S/C17H12ClN5OS/c18-12-8-25-17(15(12)16-20-9-21-23-16)22-14(24)7-10-3-1-5-13-11(10)4-2-6-19-13/h1-6,8-9H,7H2,(H,22,24)(H,20,21,23)
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n/an/a 15n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50338289
PNG
(CHEMBL1682012 | N-(4-methyl-3-(3-methyl-1H-1,2,4-t...)
Show SMILES Cc1nnc([nH]1)-c1c(C)csc1NC(=O)CN1C(=O)CCc2ccccc12
Show InChI InChI=1S/C19H19N5O2S/c1-11-10-27-19(17(11)18-20-12(2)22-23-18)21-15(25)9-24-14-6-4-3-5-13(14)7-8-16(24)26/h3-6,10H,7-9H2,1-2H3,(H,21,25)(H,20,22,23)
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n/an/a 15n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50338266
PNG
(CHEMBL1682020 | N-(4-chloro-3-(1H-1,2,4-triazol-5-...)
Show SMILES Clc1csc(NC(=O)Cc2cccc3ncccc23)c1-c1nnc[nH]1
Show InChI InChI=1S/C17H12ClN5OS/c18-12-8-25-17(15(12)16-20-9-21-23-16)22-14(24)7-10-3-1-5-13-11(10)4-2-6-19-13/h1-6,8-9H,7H2,(H,22,24)(H,20,21,23)
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n/an/a 18n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50338291
PNG
(CHEMBL1682013 | N-(4-bromo-3-(1H-1,2,4-triazol-5-y...)
Show SMILES Brc1csc(NC(=O)CN2C(=O)CCc3ccccc23)c1-c1nnc[nH]1
Show InChI InChI=1S/C17H14BrN5O2S/c18-11-8-26-17(15(11)16-19-9-20-22-16)21-13(24)7-23-12-4-2-1-3-10(12)5-6-14(23)25/h1-4,8-9H,5-7H2,(H,21,24)(H,19,20,22)
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n/an/a 25n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50338290
PNG
(CHEMBL1614820 | N-(4-methyl-3-(1H-1,2,4-triazol-5-...)
Show SMILES Cc1csc(NC(=O)CN2C(=O)CCc3ccccc23)c1-c1nnc[nH]1
Show InChI InChI=1S/C18H17N5O2S/c1-11-9-26-18(16(11)17-19-10-20-22-17)21-14(24)8-23-13-5-3-2-4-12(13)6-7-15(23)25/h2-5,9-10H,6-8H2,1H3,(H,21,24)(H,19,20,22)
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n/an/a 25n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50338289
PNG
(CHEMBL1682012 | N-(4-methyl-3-(3-methyl-1H-1,2,4-t...)
Show SMILES Cc1nnc([nH]1)-c1c(C)csc1NC(=O)CN1C(=O)CCc2ccccc12
Show InChI InChI=1S/C19H19N5O2S/c1-11-10-27-19(17(11)18-20-12(2)22-23-18)21-15(25)9-24-14-6-4-3-5-13(14)7-8-16(24)26/h3-6,10H,7-9H2,1-2H3,(H,21,25)(H,20,22,23)
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n/an/a 25n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50338264
PNG
(CHEMBL1682018 | N-(4-cyano-3-(1H-1,2,4-triazol-5-y...)
Show SMILES O=C(Cc1cccc2cnccc12)Nc1scc(C#N)c1-c1nnc[nH]1
Show InChI InChI=1S/C18H12N6OS/c19-7-13-9-26-18(16(13)17-21-10-22-24-17)23-15(25)6-11-2-1-3-12-8-20-5-4-14(11)12/h1-5,8-10H,6H2,(H,23,25)(H,21,22,24)
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n/an/a 26n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50338291
PNG
(CHEMBL1682013 | N-(4-bromo-3-(1H-1,2,4-triazol-5-y...)
Show SMILES Brc1csc(NC(=O)CN2C(=O)CCc3ccccc23)c1-c1nnc[nH]1
Show InChI InChI=1S/C17H14BrN5O2S/c18-11-8-26-17(15(11)16-19-9-20-22-16)21-13(24)7-23-12-4-2-1-3-10(12)5-6-14(23)25/h1-4,8-9H,5-7H2,(H,21,24)(H,19,20,22)
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n/an/a 28n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50338262
PNG
(CHEMBL1682016 | N-(4-bromo-3-(1H-1,2,4-triazol-5-y...)
Show SMILES Brc1csc(NC(=O)Cc2cccc3cnccc23)c1-c1nnc[nH]1
Show InChI InChI=1S/C17H12BrN5OS/c18-13-8-25-17(15(13)16-20-9-21-23-16)22-14(24)6-10-2-1-3-11-7-19-5-4-12(10)11/h1-5,7-9H,6H2,(H,22,24)(H,20,21,23)
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n/an/a 28n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50338290
PNG
(CHEMBL1614820 | N-(4-methyl-3-(1H-1,2,4-triazol-5-...)
Show SMILES Cc1csc(NC(=O)CN2C(=O)CCc3ccccc23)c1-c1nnc[nH]1
Show InChI InChI=1S/C18H17N5O2S/c1-11-9-26-18(16(11)17-19-10-20-22-17)21-14(24)8-23-13-5-3-2-4-12(13)6-7-15(23)25/h2-5,9-10H,6-8H2,1H3,(H,21,24)(H,19,20,22)
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n/an/a 31n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50338281
PNG
(CHEMBL1681791 | methyl 2-(2-(isoquinolin-5-yl)acet...)
Show SMILES COC(=O)c1c(C)csc1NC(=O)Cc1cccc2cnccc12
Show InChI InChI=1S/C18H16N2O3S/c1-11-10-24-17(16(11)18(22)23-2)20-15(21)8-12-4-3-5-13-9-19-7-6-14(12)13/h3-7,9-10H,8H2,1-2H3,(H,20,21)
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n/an/a 31n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50338290
PNG
(CHEMBL1614820 | N-(4-methyl-3-(1H-1,2,4-triazol-5-...)
Show SMILES Cc1csc(NC(=O)CN2C(=O)CCc3ccccc23)c1-c1nnc[nH]1
Show InChI InChI=1S/C18H17N5O2S/c1-11-9-26-18(16(11)17-19-10-20-22-17)21-14(24)8-23-13-5-3-2-4-12(13)6-7-15(23)25/h2-5,9-10H,6-8H2,1H3,(H,21,24)(H,19,20,22)
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n/an/a 32n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50338262
PNG
(CHEMBL1682016 | N-(4-bromo-3-(1H-1,2,4-triazol-5-y...)
Show SMILES Brc1csc(NC(=O)Cc2cccc3cnccc23)c1-c1nnc[nH]1
Show InChI InChI=1S/C17H12BrN5OS/c18-13-8-25-17(15(13)16-20-9-21-23-16)22-14(24)6-10-2-1-3-11-7-19-5-4-12(10)11/h1-5,7-9H,6H2,(H,22,24)(H,20,21,23)
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n/an/a 33n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50338265
PNG
(CHEMBL1682019 | N-(4-bromo-3-(1H-1,2,4-triazol-5-y...)
Show SMILES Brc1csc(NC(=O)Cc2cccc3ncccc23)c1-c1nnc[nH]1
Show InChI InChI=1S/C17H12BrN5OS/c18-12-8-25-17(15(12)16-20-9-21-23-16)22-14(24)7-10-3-1-5-13-11(10)4-2-6-19-13/h1-6,8-9H,7H2,(H,22,24)(H,20,21,23)
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n/an/a 34n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50338267
PNG
(CHEMBL1682021 | N-(4-cyano-3-(1H-1,2,4-triazol-5-y...)
Show SMILES O=C(Cc1cccc2ncccc12)Nc1scc(C#N)c1-c1nnc[nH]1
Show InChI InChI=1S/C18H12N6OS/c19-8-12-9-26-18(16(12)17-21-10-22-24-17)23-15(25)7-11-3-1-5-14-13(11)4-2-6-20-14/h1-6,9-10H,7H2,(H,23,25)(H,21,22,24)
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n/an/a 41n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50338266
PNG
(CHEMBL1682020 | N-(4-chloro-3-(1H-1,2,4-triazol-5-...)
Show SMILES Clc1csc(NC(=O)Cc2cccc3ncccc23)c1-c1nnc[nH]1
Show InChI InChI=1S/C17H12ClN5OS/c18-12-8-25-17(15(12)16-20-9-21-23-16)22-14(24)7-10-3-1-5-13-11(10)4-2-6-19-13/h1-6,8-9H,7H2,(H,22,24)(H,20,21,23)
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n/an/a 42n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50338291
PNG
(CHEMBL1682013 | N-(4-bromo-3-(1H-1,2,4-triazol-5-y...)
Show SMILES Brc1csc(NC(=O)CN2C(=O)CCc3ccccc23)c1-c1nnc[nH]1
Show InChI InChI=1S/C17H14BrN5O2S/c18-11-8-26-17(15(11)16-19-9-20-22-16)21-13(24)7-23-12-4-2-1-3-10(12)5-6-14(23)25/h1-4,8-9H,5-7H2,(H,21,24)(H,19,20,22)
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n/an/a 42n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50338289
PNG
(CHEMBL1682012 | N-(4-methyl-3-(3-methyl-1H-1,2,4-t...)
Show SMILES Cc1nnc([nH]1)-c1c(C)csc1NC(=O)CN1C(=O)CCc2ccccc12
Show InChI InChI=1S/C19H19N5O2S/c1-11-10-27-19(17(11)18-20-12(2)22-23-18)21-15(25)9-24-14-6-4-3-5-13(14)7-8-16(24)26/h3-6,10H,7-9H2,1-2H3,(H,21,25)(H,20,22,23)
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n/an/a 42n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50338265
PNG
(CHEMBL1682019 | N-(4-bromo-3-(1H-1,2,4-triazol-5-y...)
Show SMILES Brc1csc(NC(=O)Cc2cccc3ncccc23)c1-c1nnc[nH]1
Show InChI InChI=1S/C17H12BrN5OS/c18-12-8-25-17(15(12)16-20-9-21-23-16)22-14(24)7-10-3-1-5-13-11(10)4-2-6-19-13/h1-6,8-9H,7H2,(H,22,24)(H,20,21,23)
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n/an/a 42n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50338263
PNG
(CHEMBL1682017 | N-(4-chloro-3-(1H-1,2,4-triazol-5-...)
Show SMILES Clc1csc(NC(=O)Cc2cccc3cnccc23)c1-c1nnc[nH]1
Show InChI InChI=1S/C17H12ClN5OS/c18-13-8-25-17(15(13)16-20-9-21-23-16)22-14(24)6-10-2-1-3-11-7-19-5-4-12(10)11/h1-5,7-9H,6H2,(H,22,24)(H,20,21,23)
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n/an/a 43n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50338287
PNG
(CHEMBL1682010 | N-(4-methyl-3-(3-methyl-1H-1,2,4-t...)
Show SMILES Cc1nnc([nH]1)-c1c(C)csc1NC(=O)Cc1cccc2ncccc12
Show InChI InChI=1S/C19H17N5OS/c1-11-10-26-19(17(11)18-21-12(2)23-24-18)22-16(25)9-13-5-3-7-15-14(13)6-4-8-20-15/h3-8,10H,9H2,1-2H3,(H,22,25)(H,21,23,24)
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n/an/a 45n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50338262
PNG
(CHEMBL1682016 | N-(4-bromo-3-(1H-1,2,4-triazol-5-y...)
Show SMILES Brc1csc(NC(=O)Cc2cccc3cnccc23)c1-c1nnc[nH]1
Show InChI InChI=1S/C17H12BrN5OS/c18-13-8-25-17(15(13)16-20-9-21-23-16)22-14(24)6-10-2-1-3-11-7-19-5-4-12(10)11/h1-5,7-9H,6H2,(H,22,24)(H,20,21,23)
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n/an/a 50n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50338280
PNG
(CHEMBL1682004 | methyl 4-methyl-2-(2-(quinolin-5-y...)
Show SMILES COC(=O)c1c(C)csc1NC(=O)Cc1cccc2ncccc12
Show InChI InChI=1S/C18H16N2O3S/c1-11-10-24-17(16(11)18(22)23-2)20-15(21)9-12-5-3-7-14-13(12)6-4-8-19-14/h3-8,10H,9H2,1-2H3,(H,20,21)
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n/an/a 55n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50338281
PNG
(CHEMBL1681791 | methyl 2-(2-(isoquinolin-5-yl)acet...)
Show SMILES COC(=O)c1c(C)csc1NC(=O)Cc1cccc2cnccc12
Show InChI InChI=1S/C18H16N2O3S/c1-11-10-24-17(16(11)18(22)23-2)20-15(21)8-12-4-3-5-13-9-19-7-6-14(12)13/h3-7,9-10H,8H2,1-2H3,(H,20,21)
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n/an/a 62n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50338282
PNG
(CHEMBL1682005 | methyl 4-methyl-2-(2-(2-oxo-3,4-di...)
Show SMILES COC(=O)c1c(C)csc1NC(=O)CN1C(=O)CCc2ccccc12
Show InChI InChI=1S/C18H18N2O4S/c1-11-10-25-17(16(11)18(23)24-2)19-14(21)9-20-13-6-4-3-5-12(13)7-8-15(20)22/h3-6,10H,7-9H2,1-2H3,(H,19,21)
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n/an/a 78n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50338287
PNG
(CHEMBL1682010 | N-(4-methyl-3-(3-methyl-1H-1,2,4-t...)
Show SMILES Cc1nnc([nH]1)-c1c(C)csc1NC(=O)Cc1cccc2ncccc12
Show InChI InChI=1S/C19H17N5OS/c1-11-10-26-19(17(11)18-21-12(2)23-24-18)22-16(25)9-13-5-3-7-15-14(13)6-4-8-20-15/h3-8,10H,9H2,1-2H3,(H,22,25)(H,21,23,24)
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n/an/a 80n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50338287
PNG
(CHEMBL1682010 | N-(4-methyl-3-(3-methyl-1H-1,2,4-t...)
Show SMILES Cc1nnc([nH]1)-c1c(C)csc1NC(=O)Cc1cccc2ncccc12
Show InChI InChI=1S/C19H17N5OS/c1-11-10-26-19(17(11)18-21-12(2)23-24-18)22-16(25)9-13-5-3-7-15-14(13)6-4-8-20-15/h3-8,10H,9H2,1-2H3,(H,22,25)(H,21,23,24)
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n/an/a 81n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50338265
PNG
(CHEMBL1682019 | N-(4-bromo-3-(1H-1,2,4-triazol-5-y...)
Show SMILES Brc1csc(NC(=O)Cc2cccc3ncccc23)c1-c1nnc[nH]1
Show InChI InChI=1S/C17H12BrN5OS/c18-12-8-25-17(15(12)16-20-9-21-23-16)22-14(24)7-10-3-1-5-13-11(10)4-2-6-19-13/h1-6,8-9H,7H2,(H,22,24)(H,20,21,23)
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n/an/a 90n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50338279
PNG
(CHEMBL1682003 | methyl 4-methyl-2-(2-(quinoxalin-5...)
Show SMILES COC(=O)c1c(C)csc1NC(=O)Cc1cccc2nccnc12
Show InChI InChI=1S/C17H15N3O3S/c1-10-9-24-16(14(10)17(22)23-2)20-13(21)8-11-4-3-5-12-15(11)19-7-6-18-12/h3-7,9H,8H2,1-2H3,(H,20,21)
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n/an/a 95n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50338276
PNG
(CHEMBL1682000 | methyl 4-methyl-2-(2-(4-(3-(piperi...)
Show SMILES COC(=O)c1c(C)csc1NC(=O)Cc1ccc(OCCCN2CCCCC2)cc1
Show InChI InChI=1S/C23H30N2O4S/c1-17-16-30-22(21(17)23(27)28-2)24-20(26)15-18-7-9-19(10-8-18)29-14-6-13-25-11-4-3-5-12-25/h7-10,16H,3-6,11-15H2,1-2H3,(H,24,26)
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n/an/a 99n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50338288
PNG
(CHEMBL1682011 | N-(4-methyl-3-(1H-1,2,4-triazol-5-...)
Show SMILES Cc1csc(NC(=O)Cc2cccc3ncccc23)c1-c1nnc[nH]1
Show InChI InChI=1S/C18H15N5OS/c1-11-9-25-18(16(11)17-20-10-21-23-17)22-15(24)8-12-4-2-6-14-13(12)5-3-7-19-14/h2-7,9-10H,8H2,1H3,(H,22,24)(H,20,21,23)
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n/an/a 105n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50338280
PNG
(CHEMBL1682004 | methyl 4-methyl-2-(2-(quinolin-5-y...)
Show SMILES COC(=O)c1c(C)csc1NC(=O)Cc1cccc2ncccc12
Show InChI InChI=1S/C18H16N2O3S/c1-11-10-24-17(16(11)18(22)23-2)20-15(21)9-12-5-3-7-14-13(12)6-4-8-19-14/h3-8,10H,9H2,1-2H3,(H,20,21)
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n/an/a 110n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50338288
PNG
(CHEMBL1682011 | N-(4-methyl-3-(1H-1,2,4-triazol-5-...)
Show SMILES Cc1csc(NC(=O)Cc2cccc3ncccc23)c1-c1nnc[nH]1
Show InChI InChI=1S/C18H15N5OS/c1-11-9-25-18(16(11)17-20-10-21-23-17)22-15(24)8-12-4-2-6-14-13(12)5-3-7-19-14/h2-7,9-10H,8H2,1H3,(H,22,24)(H,20,21,23)
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n/an/a 125n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50338282
PNG
(CHEMBL1682005 | methyl 4-methyl-2-(2-(2-oxo-3,4-di...)
Show SMILES COC(=O)c1c(C)csc1NC(=O)CN1C(=O)CCc2ccccc12
Show InChI InChI=1S/C18H18N2O4S/c1-11-10-25-17(16(11)18(23)24-2)19-14(21)9-20-13-6-4-3-5-12(13)7-8-15(20)22/h3-6,10H,7-9H2,1-2H3,(H,19,21)
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n/an/a 125n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50338288
PNG
(CHEMBL1682011 | N-(4-methyl-3-(1H-1,2,4-triazol-5-...)
Show SMILES Cc1csc(NC(=O)Cc2cccc3ncccc23)c1-c1nnc[nH]1
Show InChI InChI=1S/C18H15N5OS/c1-11-9-25-18(16(11)17-20-10-21-23-17)22-15(24)8-12-4-2-6-14-13(12)5-3-7-19-14/h2-7,9-10H,8H2,1H3,(H,22,24)(H,20,21,23)
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n/an/a 143n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50338279
PNG
(CHEMBL1682003 | methyl 4-methyl-2-(2-(quinoxalin-5...)
Show SMILES COC(=O)c1c(C)csc1NC(=O)Cc1cccc2nccnc12
Show InChI InChI=1S/C17H15N3O3S/c1-10-9-24-16(14(10)17(22)23-2)20-13(21)8-11-4-3-5-12-15(11)19-7-6-18-12/h3-7,9H,8H2,1-2H3,(H,20,21)
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n/an/a 162n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50338285
PNG
(CHEMBL1682008 | N-(4-methyl-3-(3-methyl-1H-1,2,4-t...)
Show SMILES Cc1csc(NC(=O)Cc2ccc(OCCCN3CCCCC3)cc2)c1-c1nnc(C)[nH]1
Show InChI InChI=1S/C24H31N5O2S/c1-17-16-32-24(22(17)23-25-18(2)27-28-23)26-21(30)15-19-7-9-20(10-8-19)31-14-6-13-29-11-4-3-5-12-29/h7-10,16H,3-6,11-15H2,1-2H3,(H,26,30)(H,25,27,28)
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n/an/a 197n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50338284
PNG
(CHEMBL1682007 | N-(4-methyl-3-(3-methyl-1H-1,2,4-t...)
Show SMILES Cc1nnc([nH]1)-c1c(C)csc1NC(=O)Cc1ccc(cc1)-c1ccncc1
Show InChI InChI=1S/C21H19N5OS/c1-13-12-28-21(19(13)20-23-14(2)25-26-20)24-18(27)11-15-3-5-16(6-4-15)17-7-9-22-10-8-17/h3-10,12H,11H2,1-2H3,(H,24,27)(H,23,25,26)
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n/an/a 226n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50338277
PNG
(CHEMBL1682001 | methyl 4-methyl-2-(2-(4-(3-(pyrrol...)
Show SMILES COC(=O)c1c(C)csc1NC(=O)Cc1ccc(OCCCN2CCCC2)cc1
Show InChI InChI=1S/C22H28N2O4S/c1-16-15-29-21(20(16)22(26)27-2)23-19(25)14-17-6-8-18(9-7-17)28-13-5-12-24-10-3-4-11-24/h6-9,15H,3-5,10-14H2,1-2H3,(H,23,25)
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n/an/a 226n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50338286
PNG
(CHEMBL1682009 | N-(4-methyl-3-(3-methyl-1H-1,2,4-t...)
Show SMILES Cc1nnc([nH]1)-c1c(C)csc1NC(=O)Cc1cccc2nccnc12
Show InChI InChI=1S/C18H16N6OS/c1-10-9-26-18(15(10)17-21-11(2)23-24-17)22-14(25)8-12-4-3-5-13-16(12)20-7-6-19-13/h3-7,9H,8H2,1-2H3,(H,22,25)(H,21,23,24)
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n/an/a 230n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50338274
PNG
(CHEMBL1681998 | methyl 4-methyl-2-(2-(4-(pyridin-4...)
Show SMILES COC(=O)c1c(C)csc1NC(=O)Cc1ccc(cc1)-c1ccncc1
Show InChI InChI=1S/C20H18N2O3S/c1-13-12-26-19(18(13)20(24)25-2)22-17(23)11-14-3-5-15(6-4-14)16-7-9-21-10-8-16/h3-10,12H,11H2,1-2H3,(H,22,23)
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n/an/a 263n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50338274
PNG
(CHEMBL1681998 | methyl 4-methyl-2-(2-(4-(pyridin-4...)
Show SMILES COC(=O)c1c(C)csc1NC(=O)Cc1ccc(cc1)-c1ccncc1
Show InChI InChI=1S/C20H18N2O3S/c1-13-12-26-19(18(13)20(24)25-2)22-17(23)11-14-3-5-15(6-4-14)16-7-9-21-10-8-16/h3-10,12H,11H2,1-2H3,(H,22,23)
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n/an/a 283n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50338277
PNG
(CHEMBL1682001 | methyl 4-methyl-2-(2-(4-(3-(pyrrol...)
Show SMILES COC(=O)c1c(C)csc1NC(=O)Cc1ccc(OCCCN2CCCC2)cc1
Show InChI InChI=1S/C22H28N2O4S/c1-16-15-29-21(20(16)22(26)27-2)23-19(25)14-17-6-8-18(9-7-17)28-13-5-12-24-10-3-4-11-24/h6-9,15H,3-5,10-14H2,1-2H3,(H,23,25)
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n/an/a 284n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50338276
PNG
(CHEMBL1682000 | methyl 4-methyl-2-(2-(4-(3-(piperi...)
Show SMILES COC(=O)c1c(C)csc1NC(=O)Cc1ccc(OCCCN2CCCCC2)cc1
Show InChI InChI=1S/C23H30N2O4S/c1-17-16-30-22(21(17)23(27)28-2)24-20(26)15-18-7-9-19(10-8-18)29-14-6-13-25-11-4-3-5-12-25/h7-10,16H,3-6,11-15H2,1-2H3,(H,24,26)
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n/an/a 295n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50338286
PNG
(CHEMBL1682009 | N-(4-methyl-3-(3-methyl-1H-1,2,4-t...)
Show SMILES Cc1nnc([nH]1)-c1c(C)csc1NC(=O)Cc1cccc2nccnc12
Show InChI InChI=1S/C18H16N6OS/c1-10-9-26-18(15(10)17-21-11(2)23-24-17)22-14(25)8-12-4-3-5-13-16(12)20-7-6-19-13/h3-7,9H,8H2,1-2H3,(H,22,25)(H,21,23,24)
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n/an/a 298n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50338272
PNG
(CHEMBL1681996 | ethyl 4-cyano-2-(2-(4-methoxypheny...)
Show SMILES CCOC(=O)c1c(NC(=O)Cc2ccc(OC)cc2)scc1C#N
Show InChI InChI=1S/C17H16N2O4S/c1-3-23-17(21)15-12(9-18)10-24-16(15)19-14(20)8-11-4-6-13(22-2)7-5-11/h4-7,10H,3,8H2,1-2H3,(H,19,20)
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n/an/a 310n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50338284
PNG
(CHEMBL1682007 | N-(4-methyl-3-(3-methyl-1H-1,2,4-t...)
Show SMILES Cc1nnc([nH]1)-c1c(C)csc1NC(=O)Cc1ccc(cc1)-c1ccncc1
Show InChI InChI=1S/C21H19N5OS/c1-13-12-28-21(19(13)20-23-14(2)25-26-20)24-18(27)11-15-3-5-16(6-4-15)17-7-9-22-10-8-17/h3-10,12H,11H2,1-2H3,(H,24,27)(H,23,25,26)
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n/an/a 324n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50338283
PNG
(2-(4-methoxyphenyl)-N-(4-methyl-3-(3-methyl-1H-1,2...)
Show SMILES COc1ccc(CC(=O)Nc2scc(C)c2-c2nnc(C)[nH]2)cc1
Show InChI InChI=1S/C17H18N4O2S/c1-10-9-24-17(15(10)16-18-11(2)20-21-16)19-14(22)8-12-4-6-13(23-3)7-5-12/h4-7,9H,8H2,1-3H3,(H,19,22)(H,18,20,21)
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n/an/a 331n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50338272
PNG
(CHEMBL1681996 | ethyl 4-cyano-2-(2-(4-methoxypheny...)
Show SMILES CCOC(=O)c1c(NC(=O)Cc2ccc(OC)cc2)scc1C#N
Show InChI InChI=1S/C17H16N2O4S/c1-3-23-17(21)15-12(9-18)10-24-16(15)19-14(20)8-11-4-6-13(22-2)7-5-11/h4-7,10H,3,8H2,1-2H3,(H,19,20)
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n/an/a 350n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50338280
PNG
(CHEMBL1682004 | methyl 4-methyl-2-(2-(quinolin-5-y...)
Show SMILES COC(=O)c1c(C)csc1NC(=O)Cc1cccc2ncccc12
Show InChI InChI=1S/C18H16N2O3S/c1-11-10-24-17(16(11)18(22)23-2)20-15(21)9-12-5-3-7-14-13(12)6-4-8-19-14/h3-8,10H,9H2,1-2H3,(H,20,21)
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n/an/a 409n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50338285
PNG
(CHEMBL1682008 | N-(4-methyl-3-(3-methyl-1H-1,2,4-t...)
Show SMILES Cc1csc(NC(=O)Cc2ccc(OCCCN3CCCCC3)cc2)c1-c1nnc(C)[nH]1
Show InChI InChI=1S/C24H31N5O2S/c1-17-16-32-24(22(17)23-25-18(2)27-28-23)26-21(30)15-19-7-9-20(10-8-19)31-14-6-13-29-11-4-3-5-12-29/h7-10,16H,3-6,11-15H2,1-2H3,(H,26,30)(H,25,27,28)
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n/an/a 463n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50338283
PNG
(2-(4-methoxyphenyl)-N-(4-methyl-3-(3-methyl-1H-1,2...)
Show SMILES COc1ccc(CC(=O)Nc2scc(C)c2-c2nnc(C)[nH]2)cc1
Show InChI InChI=1S/C17H18N4O2S/c1-10-9-24-17(15(10)16-18-11(2)20-21-16)19-14(22)8-12-4-6-13(23-3)7-5-12/h4-7,9H,8H2,1-3H3,(H,19,22)(H,18,20,21)
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n/an/a 465n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50338275
PNG
(CHEMBL1681999 | methyl 2-(2-(4-(3-(1H-imidazol-1-y...)
Show SMILES COC(=O)c1c(C)csc1NC(=O)Cc1ccc(OCCCn2ccnc2)cc1
Show InChI InChI=1S/C21H23N3O4S/c1-15-13-29-20(19(15)21(26)27-2)23-18(25)12-16-4-6-17(7-5-16)28-11-3-9-24-10-8-22-14-24/h4-8,10,13-14H,3,9,11-12H2,1-2H3,(H,23,25)
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n/an/a 504n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50338268
PNG
(CHEMBL1681992 | methyl 2-(2-(4-methoxyphenyl)aceta...)
Show SMILES COC(=O)c1c(C)csc1NC(=O)Cc1ccc(OC)cc1
Show InChI InChI=1S/C16H17NO4S/c1-10-9-22-15(14(10)16(19)21-3)17-13(18)8-11-4-6-12(20-2)7-5-11/h4-7,9H,8H2,1-3H3,(H,17,18)
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n/an/a 590n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50338286
PNG
(CHEMBL1682009 | N-(4-methyl-3-(3-methyl-1H-1,2,4-t...)
Show SMILES Cc1nnc([nH]1)-c1c(C)csc1NC(=O)Cc1cccc2nccnc12
Show InChI InChI=1S/C18H16N6OS/c1-10-9-26-18(15(10)17-21-11(2)23-24-17)22-14(25)8-12-4-3-5-13-16(12)20-7-6-19-13/h3-7,9H,8H2,1-2H3,(H,22,25)(H,21,23,24)
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n/an/a 594n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50338275
PNG
(CHEMBL1681999 | methyl 2-(2-(4-(3-(1H-imidazol-1-y...)
Show SMILES COC(=O)c1c(C)csc1NC(=O)Cc1ccc(OCCCn2ccnc2)cc1
Show InChI InChI=1S/C21H23N3O4S/c1-15-13-29-20(19(15)21(26)27-2)23-18(25)12-16-4-6-17(7-5-16)28-11-3-9-24-10-8-22-14-24/h4-8,10,13-14H,3,9,11-12H2,1-2H3,(H,23,25)
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n/an/a 597n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50338276
PNG
(CHEMBL1682000 | methyl 4-methyl-2-(2-(4-(3-(piperi...)
Show SMILES COC(=O)c1c(C)csc1NC(=O)Cc1ccc(OCCCN2CCCCC2)cc1
Show InChI InChI=1S/C23H30N2O4S/c1-17-16-30-22(21(17)23(27)28-2)24-20(26)15-18-7-9-19(10-8-18)29-14-6-13-25-11-4-3-5-12-25/h7-10,16H,3-6,11-15H2,1-2H3,(H,24,26)
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n/an/a 613n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50338278
PNG
(CHEMBL1682002 | methyl 2-(2-(1H-indol-7-yl)acetami...)
Show SMILES COC(=O)c1c(C)csc1NC(=O)Cc1cccc2cc[nH]c12
Show InChI InChI=1S/C17H16N2O3S/c1-10-9-23-16(14(10)17(21)22-2)19-13(20)8-12-5-3-4-11-6-7-18-15(11)12/h3-7,9,18H,8H2,1-2H3,(H,19,20)
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n/an/a 686n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50338268
PNG
(CHEMBL1681992 | methyl 2-(2-(4-methoxyphenyl)aceta...)
Show SMILES COC(=O)c1c(C)csc1NC(=O)Cc1ccc(OC)cc1
Show InChI InChI=1S/C16H17NO4S/c1-10-9-22-15(14(10)16(19)21-3)17-13(18)8-11-4-6-12(20-2)7-5-11/h4-7,9H,8H2,1-3H3,(H,17,18)
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n/an/a 700n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50338282
PNG
(CHEMBL1682005 | methyl 4-methyl-2-(2-(2-oxo-3,4-di...)
Show SMILES COC(=O)c1c(C)csc1NC(=O)CN1C(=O)CCc2ccccc12
Show InChI InChI=1S/C18H18N2O4S/c1-11-10-25-17(16(11)18(23)24-2)19-14(21)9-20-13-6-4-3-5-12(13)7-8-15(20)22/h3-6,10H,7-9H2,1-2H3,(H,19,21)
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n/an/a 703n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50338279
PNG
(CHEMBL1682003 | methyl 4-methyl-2-(2-(quinoxalin-5...)
Show SMILES COC(=O)c1c(C)csc1NC(=O)Cc1cccc2nccnc12
Show InChI InChI=1S/C17H15N3O3S/c1-10-9-24-16(14(10)17(22)23-2)20-13(21)8-11-4-3-5-12-15(11)19-7-6-18-12/h3-7,9H,8H2,1-2H3,(H,20,21)
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n/an/a 765n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50338283
PNG
(2-(4-methoxyphenyl)-N-(4-methyl-3-(3-methyl-1H-1,2...)
Show SMILES COc1ccc(CC(=O)Nc2scc(C)c2-c2nnc(C)[nH]2)cc1
Show InChI InChI=1S/C17H18N4O2S/c1-10-9-24-17(15(10)16-18-11(2)20-21-16)19-14(22)8-12-4-6-13(23-3)7-5-12/h4-7,9H,8H2,1-3H3,(H,19,22)(H,18,20,21)
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n/an/a 824n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50338281
PNG
(CHEMBL1681791 | methyl 2-(2-(isoquinolin-5-yl)acet...)
Show SMILES COC(=O)c1c(C)csc1NC(=O)Cc1cccc2cnccc12
Show InChI InChI=1S/C18H16N2O3S/c1-11-10-24-17(16(11)18(22)23-2)20-15(21)8-12-4-3-5-13-9-19-7-6-14(12)13/h3-7,9-10H,8H2,1-2H3,(H,20,21)
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n/an/a 863n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50338272
PNG
(CHEMBL1681996 | ethyl 4-cyano-2-(2-(4-methoxypheny...)
Show SMILES CCOC(=O)c1c(NC(=O)Cc2ccc(OC)cc2)scc1C#N
Show InChI InChI=1S/C17H16N2O4S/c1-3-23-17(21)15-12(9-18)10-24-16(15)19-14(20)8-11-4-6-13(22-2)7-5-11/h4-7,10H,3,8H2,1-2H3,(H,19,20)
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n/an/a 930n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50338278
PNG
(CHEMBL1682002 | methyl 2-(2-(1H-indol-7-yl)acetami...)
Show SMILES COC(=O)c1c(C)csc1NC(=O)Cc1cccc2cc[nH]c12
Show InChI InChI=1S/C17H16N2O3S/c1-10-9-23-16(14(10)17(21)22-2)19-13(20)8-12-5-3-4-11-6-7-18-15(11)12/h3-7,9,18H,8H2,1-2H3,(H,19,20)
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n/an/a 1.02E+3n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50338273
PNG
(CHEMBL1681997 | ethyl 4-ethynyl-2-(2-(4-methoxyphe...)
Show SMILES CCOC(=O)c1c(NC(=O)Cc2ccc(OC)cc2)scc1C#C
Show InChI InChI=1S/C18H17NO4S/c1-4-13-11-24-17(16(13)18(21)23-5-2)19-15(20)10-12-6-8-14(22-3)9-7-12/h1,6-9,11H,5,10H2,2-3H3,(H,19,20)
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n/an/a 1.05E+3n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50338284
PNG
(CHEMBL1682007 | N-(4-methyl-3-(3-methyl-1H-1,2,4-t...)
Show SMILES Cc1nnc([nH]1)-c1c(C)csc1NC(=O)Cc1ccc(cc1)-c1ccncc1
Show InChI InChI=1S/C21H19N5OS/c1-13-12-28-21(19(13)20-23-14(2)25-26-20)24-18(27)11-15-3-5-16(6-4-15)17-7-9-22-10-8-17/h3-10,12H,11H2,1-2H3,(H,24,27)(H,23,25,26)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50332040
PNG
(CHEMBL1288895 | methyl 3-(2-(thiophen-2-yl)acetami...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1cccs1
Show InChI InChI=1S/C12H11NO3S2/c1-16-12(15)11-9(4-6-18-11)13-10(14)7-8-3-2-5-17-8/h2-6H,7H2,1H3,(H,13,14)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50338285
PNG
(CHEMBL1682008 | N-(4-methyl-3-(3-methyl-1H-1,2,4-t...)
Show SMILES Cc1csc(NC(=O)Cc2ccc(OCCCN3CCCCC3)cc2)c1-c1nnc(C)[nH]1
Show InChI InChI=1S/C24H31N5O2S/c1-17-16-32-24(22(17)23-25-18(2)27-28-23)26-21(30)15-19-7-9-20(10-8-19)31-14-6-13-29-11-4-3-5-12-29/h7-10,16H,3-6,11-15H2,1-2H3,(H,26,30)(H,25,27,28)
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n/an/a 1.62E+3n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50338274
PNG
(CHEMBL1681998 | methyl 4-methyl-2-(2-(4-(pyridin-4...)
Show SMILES COC(=O)c1c(C)csc1NC(=O)Cc1ccc(cc1)-c1ccncc1
Show InChI InChI=1S/C20H18N2O3S/c1-13-12-26-19(18(13)20(24)25-2)22-17(23)11-14-3-5-15(6-4-14)16-7-9-21-10-8-16/h3-10,12H,11H2,1-2H3,(H,22,23)
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n/an/a 1.84E+3n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50332040
PNG
(CHEMBL1288895 | methyl 3-(2-(thiophen-2-yl)acetami...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1cccs1
Show InChI InChI=1S/C12H11NO3S2/c1-16-12(15)11-9(4-6-18-11)13-10(14)7-8-3-2-5-17-8/h2-6H,7H2,1H3,(H,13,14)
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n/an/a 2.20E+3n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50338277
PNG
(CHEMBL1682001 | methyl 4-methyl-2-(2-(4-(3-(pyrrol...)
Show SMILES COC(=O)c1c(C)csc1NC(=O)Cc1ccc(OCCCN2CCCC2)cc1
Show InChI InChI=1S/C22H28N2O4S/c1-16-15-29-21(20(16)22(26)27-2)23-19(25)14-17-6-8-18(9-7-17)28-13-5-12-24-10-3-4-11-24/h6-9,15H,3-5,10-14H2,1-2H3,(H,23,25)
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n/an/a 2.57E+3n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50338273
PNG
(CHEMBL1681997 | ethyl 4-ethynyl-2-(2-(4-methoxyphe...)
Show SMILES CCOC(=O)c1c(NC(=O)Cc2ccc(OC)cc2)scc1C#C
Show InChI InChI=1S/C18H17NO4S/c1-4-13-11-24-17(16(13)18(21)23-5-2)19-15(20)10-12-6-8-14(22-3)9-7-12/h1,6-9,11H,5,10H2,2-3H3,(H,19,20)
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n/an/a 3.02E+3n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50338268
PNG
(CHEMBL1681992 | methyl 2-(2-(4-methoxyphenyl)aceta...)
Show SMILES COC(=O)c1c(C)csc1NC(=O)Cc1ccc(OC)cc1
Show InChI InChI=1S/C16H17NO4S/c1-10-9-22-15(14(10)16(19)21-3)17-13(18)8-11-4-6-12(20-2)7-5-11/h4-7,9H,8H2,1-3H3,(H,17,18)
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n/an/a 3.14E+3n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50338278
PNG
(CHEMBL1682002 | methyl 2-(2-(1H-indol-7-yl)acetami...)
Show SMILES COC(=O)c1c(C)csc1NC(=O)Cc1cccc2cc[nH]c12
Show InChI InChI=1S/C17H16N2O3S/c1-10-9-23-16(14(10)17(21)22-2)19-13(20)8-12-5-3-4-11-6-7-18-15(11)12/h3-7,9,18H,8H2,1-2H3,(H,19,20)
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n/an/a 4.15E+3n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50338275
PNG
(CHEMBL1681999 | methyl 2-(2-(4-(3-(1H-imidazol-1-y...)
Show SMILES COC(=O)c1c(C)csc1NC(=O)Cc1ccc(OCCCn2ccnc2)cc1
Show InChI InChI=1S/C21H23N3O4S/c1-15-13-29-20(19(15)21(26)27-2)23-18(25)12-16-4-6-17(7-5-16)28-11-3-9-24-10-8-22-14-24/h4-8,10,13-14H,3,9,11-12H2,1-2H3,(H,23,25)
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n/an/a 4.52E+3n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50338284
PNG
(CHEMBL1682007 | N-(4-methyl-3-(3-methyl-1H-1,2,4-t...)
Show SMILES Cc1nnc([nH]1)-c1c(C)csc1NC(=O)Cc1ccc(cc1)-c1ccncc1
Show InChI InChI=1S/C21H19N5OS/c1-13-12-28-21(19(13)20-23-14(2)25-26-20)24-18(27)11-15-3-5-16(6-4-15)17-7-9-22-10-8-17/h3-10,12H,11H2,1-2H3,(H,24,27)(H,23,25,26)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50338284
PNG
(CHEMBL1682007 | N-(4-methyl-3-(3-methyl-1H-1,2,4-t...)
Show SMILES Cc1nnc([nH]1)-c1c(C)csc1NC(=O)Cc1ccc(cc1)-c1ccncc1
Show InChI InChI=1S/C21H19N5OS/c1-13-12-28-21(19(13)20-23-14(2)25-26-20)24-18(27)11-15-3-5-16(6-4-15)17-7-9-22-10-8-17/h3-10,12H,11H2,1-2H3,(H,24,27)(H,23,25,26)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50338285
PNG
(CHEMBL1682008 | N-(4-methyl-3-(3-methyl-1H-1,2,4-t...)
Show SMILES Cc1csc(NC(=O)Cc2ccc(OCCCN3CCCCC3)cc2)c1-c1nnc(C)[nH]1
Show InChI InChI=1S/C24H31N5O2S/c1-17-16-32-24(22(17)23-25-18(2)27-28-23)26-21(30)15-19-7-9-20(10-8-19)31-14-6-13-29-11-4-3-5-12-29/h7-10,16H,3-6,11-15H2,1-2H3,(H,26,30)(H,25,27,28)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50338286
PNG
(CHEMBL1682009 | N-(4-methyl-3-(3-methyl-1H-1,2,4-t...)
Show SMILES Cc1nnc([nH]1)-c1c(C)csc1NC(=O)Cc1cccc2nccnc12
Show InChI InChI=1S/C18H16N6OS/c1-10-9-26-18(15(10)17-21-11(2)23-24-17)22-14(25)8-12-4-3-5-13-16(12)20-7-6-19-13/h3-7,9H,8H2,1-2H3,(H,22,25)(H,21,23,24)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50338285
PNG
(CHEMBL1682008 | N-(4-methyl-3-(3-methyl-1H-1,2,4-t...)
Show SMILES Cc1csc(NC(=O)Cc2ccc(OCCCN3CCCCC3)cc2)c1-c1nnc(C)[nH]1
Show InChI InChI=1S/C24H31N5O2S/c1-17-16-32-24(22(17)23-25-18(2)27-28-23)26-21(30)15-19-7-9-20(10-8-19)31-14-6-13-29-11-4-3-5-12-29/h7-10,16H,3-6,11-15H2,1-2H3,(H,26,30)(H,25,27,28)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50338286
PNG
(CHEMBL1682009 | N-(4-methyl-3-(3-methyl-1H-1,2,4-t...)
Show SMILES Cc1nnc([nH]1)-c1c(C)csc1NC(=O)Cc1cccc2nccnc12
Show InChI InChI=1S/C18H16N6OS/c1-10-9-26-18(15(10)17-21-11(2)23-24-17)22-14(25)8-12-4-3-5-13-16(12)20-7-6-19-13/h3-7,9H,8H2,1-2H3,(H,22,25)(H,21,23,24)
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Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50338270
PNG
(CHEMBL1681994 | ethyl 4-cyclopropyl-2-(2-(4-methox...)
Show SMILES CCOC(=O)c1c(NC(=O)Cc2ccc(OC)cc2)scc1C1CC1
Show InChI InChI=1S/C19H21NO4S/c1-3-24-19(22)17-15(13-6-7-13)11-25-18(17)20-16(21)10-12-4-8-14(23-2)9-5-12/h4-5,8-9,11,13H,3,6-7,10H2,1-2H3,(H,20,21)
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n/an/a 6.29E+3n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50338269
PNG
(CHEMBL1681993 | methyl 4-ethyl-2-(2-(4-methoxyphen...)
Show SMILES CCc1csc(NC(=O)Cc2ccc(OC)cc2)c1C(=O)OC
Show InChI InChI=1S/C17H19NO4S/c1-4-12-10-23-16(15(12)17(20)22-3)18-14(19)9-11-5-7-13(21-2)8-6-11/h5-8,10H,4,9H2,1-3H3,(H,18,19)
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n/an/a 9.11E+3n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50338270
PNG
(CHEMBL1681994 | ethyl 4-cyclopropyl-2-(2-(4-methox...)
Show SMILES CCOC(=O)c1c(NC(=O)Cc2ccc(OC)cc2)scc1C1CC1
Show InChI InChI=1S/C19H21NO4S/c1-3-24-19(22)17-15(13-6-7-13)11-25-18(17)20-16(21)10-12-4-8-14(23-2)9-5-12/h4-5,8-9,11,13H,3,6-7,10H2,1-2H3,(H,20,21)
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n/an/a 9.62E+3n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50338270
PNG
(CHEMBL1681994 | ethyl 4-cyclopropyl-2-(2-(4-methox...)
Show SMILES CCOC(=O)c1c(NC(=O)Cc2ccc(OC)cc2)scc1C1CC1
Show InChI InChI=1S/C19H21NO4S/c1-3-24-19(22)17-15(13-6-7-13)11-25-18(17)20-16(21)10-12-4-8-14(23-2)9-5-12/h4-5,8-9,11,13H,3,6-7,10H2,1-2H3,(H,20,21)
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n/an/a 1.56E+4n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50338271
PNG
(CHEMBL1681995 | ethyl 2-(2-(4-methoxyphenyl)acetam...)
Show SMILES CCOC(=O)c1c(NC(=O)Cc2ccc(OC)cc2)scc1C(F)(F)F
Show InChI InChI=1S/C17H16F3NO4S/c1-3-25-16(23)14-12(17(18,19)20)9-26-15(14)21-13(22)8-10-4-6-11(24-2)7-5-10/h4-7,9H,3,8H2,1-2H3,(H,21,22)
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n/an/a 1.89E+4n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50338269
PNG
(CHEMBL1681993 | methyl 4-ethyl-2-(2-(4-methoxyphen...)
Show SMILES CCc1csc(NC(=O)Cc2ccc(OC)cc2)c1C(=O)OC
Show InChI InChI=1S/C17H19NO4S/c1-4-12-10-23-16(15(12)17(20)22-3)18-14(19)9-11-5-7-13(21-2)8-6-11/h5-8,10H,4,9H2,1-3H3,(H,18,19)
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n/an/a 1.93E+4n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50338291
PNG
(CHEMBL1682013 | N-(4-bromo-3-(1H-1,2,4-triazol-5-y...)
Show SMILES Brc1csc(NC(=O)CN2C(=O)CCc3ccccc23)c1-c1nnc[nH]1
Show InChI InChI=1S/C17H14BrN5O2S/c18-11-8-26-17(15(11)16-19-9-20-22-16)21-13(24)7-23-12-4-2-1-3-10(12)5-6-14(23)25/h1-4,8-9H,5-7H2,(H,21,24)(H,19,20,22)
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n/an/a>2.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50338269
PNG
(CHEMBL1681993 | methyl 4-ethyl-2-(2-(4-methoxyphen...)
Show SMILES CCc1csc(NC(=O)Cc2ccc(OC)cc2)c1C(=O)OC
Show InChI InChI=1S/C17H19NO4S/c1-4-12-10-23-16(15(12)17(20)22-3)18-14(19)9-11-5-7-13(21-2)8-6-11/h5-8,10H,4,9H2,1-3H3,(H,18,19)
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n/an/a 2.25E+4n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50332040
PNG
(CHEMBL1288895 | methyl 3-(2-(thiophen-2-yl)acetami...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1cccs1
Show InChI InChI=1S/C12H11NO3S2/c1-16-12(15)11-9(4-6-18-11)13-10(14)7-8-3-2-5-17-8/h2-6H,7H2,1H3,(H,13,14)
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n/an/a 2.30E+4n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50338273
PNG
(CHEMBL1681997 | ethyl 4-ethynyl-2-(2-(4-methoxyphe...)
Show SMILES CCOC(=O)c1c(NC(=O)Cc2ccc(OC)cc2)scc1C#C
Show InChI InChI=1S/C18H17NO4S/c1-4-13-11-24-17(16(13)18(21)23-5-2)19-15(20)10-12-6-8-14(22-3)9-7-12/h1,6-9,11H,5,10H2,2-3H3,(H,19,20)
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n/an/a 2.84E+4n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50338267
PNG
(CHEMBL1682021 | N-(4-cyano-3-(1H-1,2,4-triazol-5-y...)
Show SMILES O=C(Cc1cccc2ncccc12)Nc1scc(C#N)c1-c1nnc[nH]1
Show InChI InChI=1S/C18H12N6OS/c19-8-12-9-26-18(16(12)17-21-10-22-24-17)23-15(25)7-11-3-1-5-14-13(11)4-2-6-20-14/h1-6,9-10H,7H2,(H,23,25)(H,21,22,24)
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n/an/a 3.51E+4n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50338271
PNG
(CHEMBL1681995 | ethyl 2-(2-(4-methoxyphenyl)acetam...)
Show SMILES CCOC(=O)c1c(NC(=O)Cc2ccc(OC)cc2)scc1C(F)(F)F
Show InChI InChI=1S/C17H16F3NO4S/c1-3-25-16(23)14-12(17(18,19)20)9-26-15(14)21-13(22)8-10-4-6-11(24-2)7-5-10/h4-7,9H,3,8H2,1-2H3,(H,21,22)
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n/an/a 3.88E+4n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50338288
PNG
(CHEMBL1682011 | N-(4-methyl-3-(1H-1,2,4-triazol-5-...)
Show SMILES Cc1csc(NC(=O)Cc2cccc3ncccc23)c1-c1nnc[nH]1
Show InChI InChI=1S/C18H15N5OS/c1-11-9-25-18(16(11)17-20-10-21-23-17)22-15(24)8-12-4-2-6-14-13(12)5-3-7-19-14/h2-7,9-10H,8H2,1H3,(H,22,24)(H,20,21,23)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50338290
PNG
(CHEMBL1614820 | N-(4-methyl-3-(1H-1,2,4-triazol-5-...)
Show SMILES Cc1csc(NC(=O)CN2C(=O)CCc3ccccc23)c1-c1nnc[nH]1
Show InChI InChI=1S/C18H17N5O2S/c1-11-9-26-18(16(11)17-19-10-20-22-17)21-14(24)8-23-13-5-3-2-4-12(13)6-7-15(23)25/h2-5,9-10H,6-8H2,1H3,(H,21,24)(H,19,20,22)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50338292
PNG
(CHEMBL1682014 | N-(4-chloro-3-(1H-1,2,4-triazol-5-...)
Show SMILES Clc1csc(NC(=O)CN2C(=O)CCc3ccccc23)c1-c1nnc[nH]1
Show InChI InChI=1S/C17H14ClN5O2S/c18-11-8-26-17(15(11)16-19-9-20-22-16)21-13(24)7-23-12-4-2-1-3-10(12)5-6-14(23)25/h1-4,8-9H,5-7H2,(H,21,24)(H,19,20,22)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50332040
PNG
(CHEMBL1288895 | methyl 3-(2-(thiophen-2-yl)acetami...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1cccs1
Show InChI InChI=1S/C12H11NO3S2/c1-16-12(15)11-9(4-6-18-11)13-10(14)7-8-3-2-5-17-8/h2-6H,7H2,1H3,(H,13,14)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50338292
PNG
(CHEMBL1682014 | N-(4-chloro-3-(1H-1,2,4-triazol-5-...)
Show SMILES Clc1csc(NC(=O)CN2C(=O)CCc3ccccc23)c1-c1nnc[nH]1
Show InChI InChI=1S/C17H14ClN5O2S/c18-11-8-26-17(15(11)16-19-9-20-22-16)21-13(24)7-23-12-4-2-1-3-10(12)5-6-14(23)25/h1-4,8-9H,5-7H2,(H,21,24)(H,19,20,22)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50338267
PNG
(CHEMBL1682021 | N-(4-cyano-3-(1H-1,2,4-triazol-5-y...)
Show SMILES O=C(Cc1cccc2ncccc12)Nc1scc(C#N)c1-c1nnc[nH]1
Show InChI InChI=1S/C18H12N6OS/c19-8-12-9-26-18(16(12)17-21-10-22-24-17)23-15(25)7-11-3-1-5-14-13(11)4-2-6-20-14/h1-6,9-10H,7H2,(H,23,25)(H,21,22,24)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50338291
PNG
(CHEMBL1682013 | N-(4-bromo-3-(1H-1,2,4-triazol-5-y...)
Show SMILES Brc1csc(NC(=O)CN2C(=O)CCc3ccccc23)c1-c1nnc[nH]1
Show InChI InChI=1S/C17H14BrN5O2S/c18-11-8-26-17(15(11)16-19-9-20-22-16)21-13(24)7-23-12-4-2-1-3-10(12)5-6-14(23)25/h1-4,8-9H,5-7H2,(H,21,24)(H,19,20,22)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50338263
PNG
(CHEMBL1682017 | N-(4-chloro-3-(1H-1,2,4-triazol-5-...)
Show SMILES Clc1csc(NC(=O)Cc2cccc3cnccc23)c1-c1nnc[nH]1
Show InChI InChI=1S/C17H12ClN5OS/c18-13-8-25-17(15(13)16-20-9-21-23-16)22-14(24)6-10-2-1-3-11-7-19-5-4-12(10)11/h1-5,7-9H,6H2,(H,22,24)(H,20,21,23)
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Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50338289
PNG
(CHEMBL1682012 | N-(4-methyl-3-(3-methyl-1H-1,2,4-t...)
Show SMILES Cc1nnc([nH]1)-c1c(C)csc1NC(=O)CN1C(=O)CCc2ccccc12
Show InChI InChI=1S/C19H19N5O2S/c1-11-10-27-19(17(11)18-20-12(2)22-23-18)21-15(25)9-24-14-6-4-3-5-13(14)7-8-16(24)26/h3-6,10H,7-9H2,1-2H3,(H,21,25)(H,20,22,23)
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Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50338293
PNG
(CHEMBL1682015 | N-(4-cyano-3-(1H-1,2,4-triazol-5-y...)
Show SMILES O=C(CN1C(=O)CCc2ccccc12)Nc1scc(C#N)c1-c1nnc[nH]1
Show InChI InChI=1S/C18H14N6O2S/c19-7-12-9-27-18(16(12)17-20-10-21-23-17)22-14(25)8-24-13-4-2-1-3-11(13)5-6-15(24)26/h1-4,9-10H,5-6,8H2,(H,22,25)(H,20,21,23)
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Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50338264
PNG
(CHEMBL1682018 | N-(4-cyano-3-(1H-1,2,4-triazol-5-y...)
Show SMILES O=C(Cc1cccc2cnccc12)Nc1scc(C#N)c1-c1nnc[nH]1
Show InChI InChI=1S/C18H12N6OS/c19-7-13-9-26-18(16(13)17-21-10-22-24-17)23-15(25)6-11-2-1-3-12-8-20-5-4-14(11)12/h1-5,8-10H,6H2,(H,23,25)(H,21,22,24)
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Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50338290
PNG
(CHEMBL1614820 | N-(4-methyl-3-(1H-1,2,4-triazol-5-...)
Show SMILES Cc1csc(NC(=O)CN2C(=O)CCc3ccccc23)c1-c1nnc[nH]1
Show InChI InChI=1S/C18H17N5O2S/c1-11-9-26-18(16(11)17-19-10-20-22-17)21-14(24)8-23-13-5-3-2-4-12(13)6-7-15(23)25/h2-5,9-10H,6-8H2,1H3,(H,21,24)(H,19,20,22)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50338262
PNG
(CHEMBL1682016 | N-(4-bromo-3-(1H-1,2,4-triazol-5-y...)
Show SMILES Brc1csc(NC(=O)Cc2cccc3cnccc23)c1-c1nnc[nH]1
Show InChI InChI=1S/C17H12BrN5OS/c18-13-8-25-17(15(13)16-20-9-21-23-16)22-14(24)6-10-2-1-3-11-7-19-5-4-12(10)11/h1-5,7-9H,6H2,(H,22,24)(H,20,21,23)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50338263
PNG
(CHEMBL1682017 | N-(4-chloro-3-(1H-1,2,4-triazol-5-...)
Show SMILES Clc1csc(NC(=O)Cc2cccc3cnccc23)c1-c1nnc[nH]1
Show InChI InChI=1S/C17H12ClN5OS/c18-13-8-25-17(15(13)16-20-9-21-23-16)22-14(24)6-10-2-1-3-11-7-19-5-4-12(10)11/h1-5,7-9H,6H2,(H,22,24)(H,20,21,23)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50338289
PNG
(CHEMBL1682012 | N-(4-methyl-3-(3-methyl-1H-1,2,4-t...)
Show SMILES Cc1nnc([nH]1)-c1c(C)csc1NC(=O)CN1C(=O)CCc2ccccc12
Show InChI InChI=1S/C19H19N5O2S/c1-11-10-27-19(17(11)18-20-12(2)22-23-18)21-15(25)9-24-14-6-4-3-5-13(14)7-8-16(24)26/h3-6,10H,7-9H2,1-2H3,(H,21,25)(H,20,22,23)
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Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50338287
PNG
(CHEMBL1682010 | N-(4-methyl-3-(3-methyl-1H-1,2,4-t...)
Show SMILES Cc1nnc([nH]1)-c1c(C)csc1NC(=O)Cc1cccc2ncccc12
Show InChI InChI=1S/C19H17N5OS/c1-11-10-26-19(17(11)18-21-12(2)23-24-18)22-16(25)9-13-5-3-7-15-14(13)6-4-8-20-15/h3-8,10H,9H2,1-2H3,(H,22,25)(H,21,23,24)
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Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50338266
PNG
(CHEMBL1682020 | N-(4-chloro-3-(1H-1,2,4-triazol-5-...)
Show SMILES Clc1csc(NC(=O)Cc2cccc3ncccc23)c1-c1nnc[nH]1
Show InChI InChI=1S/C17H12ClN5OS/c18-12-8-25-17(15(12)16-20-9-21-23-16)22-14(24)7-10-3-1-5-13-11(10)4-2-6-19-13/h1-6,8-9H,7H2,(H,22,24)(H,20,21,23)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50338288
PNG
(CHEMBL1682011 | N-(4-methyl-3-(1H-1,2,4-triazol-5-...)
Show SMILES Cc1csc(NC(=O)Cc2cccc3ncccc23)c1-c1nnc[nH]1
Show InChI InChI=1S/C18H15N5OS/c1-11-9-25-18(16(11)17-20-10-21-23-17)22-15(24)8-12-4-2-6-14-13(12)5-3-7-19-14/h2-7,9-10H,8H2,1H3,(H,22,24)(H,20,21,23)
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Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50338293
PNG
(CHEMBL1682015 | N-(4-cyano-3-(1H-1,2,4-triazol-5-y...)
Show SMILES O=C(CN1C(=O)CCc2ccccc12)Nc1scc(C#N)c1-c1nnc[nH]1
Show InChI InChI=1S/C18H14N6O2S/c19-7-12-9-27-18(16(12)17-20-10-21-23-17)22-14(25)8-24-13-4-2-1-3-11(13)5-6-15(24)26/h1-4,9-10H,5-6,8H2,(H,22,25)(H,20,21,23)
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Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50338266
PNG
(CHEMBL1682020 | N-(4-chloro-3-(1H-1,2,4-triazol-5-...)
Show SMILES Clc1csc(NC(=O)Cc2cccc3ncccc23)c1-c1nnc[nH]1
Show InChI InChI=1S/C17H12ClN5OS/c18-12-8-25-17(15(12)16-20-9-21-23-16)22-14(24)7-10-3-1-5-13-11(10)4-2-6-19-13/h1-6,8-9H,7H2,(H,22,24)(H,20,21,23)
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Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50338265
PNG
(CHEMBL1682019 | N-(4-bromo-3-(1H-1,2,4-triazol-5-y...)
Show SMILES Brc1csc(NC(=O)Cc2cccc3ncccc23)c1-c1nnc[nH]1
Show InChI InChI=1S/C17H12BrN5OS/c18-12-8-25-17(15(12)16-20-9-21-23-16)22-14(24)7-10-3-1-5-13-11(10)4-2-6-19-13/h1-6,8-9H,7H2,(H,22,24)(H,20,21,23)
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Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50338265
PNG
(CHEMBL1682019 | N-(4-bromo-3-(1H-1,2,4-triazol-5-y...)
Show SMILES Brc1csc(NC(=O)Cc2cccc3ncccc23)c1-c1nnc[nH]1
Show InChI InChI=1S/C17H12BrN5OS/c18-12-8-25-17(15(12)16-20-9-21-23-16)22-14(24)7-10-3-1-5-13-11(10)4-2-6-19-13/h1-6,8-9H,7H2,(H,22,24)(H,20,21,23)
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Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50338271
PNG
(CHEMBL1681995 | ethyl 2-(2-(4-methoxyphenyl)acetam...)
Show SMILES CCOC(=O)c1c(NC(=O)Cc2ccc(OC)cc2)scc1C(F)(F)F
Show InChI InChI=1S/C17H16F3NO4S/c1-3-25-16(23)14-12(17(18,19)20)9-26-15(14)21-13(22)8-10-4-6-11(24-2)7-5-10/h4-7,9H,3,8H2,1-2H3,(H,21,22)
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Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50332040
PNG
(CHEMBL1288895 | methyl 3-(2-(thiophen-2-yl)acetami...)
Show SMILES COC(=O)c1sccc1NC(=O)Cc1cccs1
Show InChI InChI=1S/C12H11NO3S2/c1-16-12(15)11-9(4-6-18-11)13-10(14)7-8-3-2-5-17-8/h2-6H,7H2,1H3,(H,13,14)
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Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50338287
PNG
(CHEMBL1682010 | N-(4-methyl-3-(3-methyl-1H-1,2,4-t...)
Show SMILES Cc1nnc([nH]1)-c1c(C)csc1NC(=O)Cc1cccc2ncccc12
Show InChI InChI=1S/C19H17N5OS/c1-11-10-26-19(17(11)18-21-12(2)23-24-18)22-16(25)9-13-5-3-7-15-14(13)6-4-8-20-15/h3-8,10H,9H2,1-2H3,(H,22,25)(H,21,23,24)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50338262
PNG
(CHEMBL1682016 | N-(4-bromo-3-(1H-1,2,4-triazol-5-y...)
Show SMILES Brc1csc(NC(=O)Cc2cccc3cnccc23)c1-c1nnc[nH]1
Show InChI InChI=1S/C17H12BrN5OS/c18-13-8-25-17(15(13)16-20-9-21-23-16)22-14(24)6-10-2-1-3-11-7-19-5-4-12(10)11/h1-5,7-9H,6H2,(H,22,24)(H,20,21,23)
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Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50338264
PNG
(CHEMBL1682018 | N-(4-cyano-3-(1H-1,2,4-triazol-5-y...)
Show SMILES O=C(Cc1cccc2cnccc12)Nc1scc(C#N)c1-c1nnc[nH]1
Show InChI InChI=1S/C18H12N6OS/c19-7-13-9-26-18(16(13)17-21-10-22-24-17)23-15(25)6-11-2-1-3-12-8-20-5-4-14(11)12/h1-5,8-10H,6H2,(H,23,25)(H,21,22,24)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 1838-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.046
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%