Affinity Data by PubMed id=21333408

PubMed code 21333408

Found 21 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50340725 (CHEMBL1668584 \| N,5,7-trimethyl-3-(phenylsulfonyl)...) Show SMILES CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor				Eur J Med Chem 46: 1189-97 (2011) Article DOI: 10.1016/j.ejmech.2011.01.038 BindingDB Entry DOI: 10.7270/Q2HT2PMN
Chemical Diversity Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50340725 (CHEMBL1668584 \| N,5,7-trimethyl-3-(phenylsulfonyl)...) Show SMILES CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.260	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...				Eur J Med Chem 46: 1189-97 (2011) Article DOI: 10.1016/j.ejmech.2011.01.038 BindingDB Entry DOI: 10.7270/Q2HT2PMN
Chemical Diversity Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50340726 (5,7-dimethyl-2-(methylthio)-3-(phenylsulfonyl)pyra...) Show SMILES CSc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...				Eur J Med Chem 46: 1189-97 (2011) Article DOI: 10.1016/j.ejmech.2011.01.038 BindingDB Entry DOI: 10.7270/Q2HT2PMN
Chemical Diversity Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50340730 (5,7-Dimethyl-2-(ethylthio)-3-phenylsulfonyl-pyrazo...) Show SMILES CCSc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.91	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...				Eur J Med Chem 46: 1189-97 (2011) Article DOI: 10.1016/j.ejmech.2011.01.038 BindingDB Entry DOI: 10.7270/Q2HT2PMN
Chemical Diversity Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50340726 (5,7-dimethyl-2-(methylthio)-3-(phenylsulfonyl)pyra...) Show SMILES CSc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor				Eur J Med Chem 46: 1189-97 (2011) Article DOI: 10.1016/j.ejmech.2011.01.038 BindingDB Entry DOI: 10.7270/Q2HT2PMN
Chemical Diversity Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50340731 (CHEMBL1762569 \| N,N,5,7-Tetramethyl-3-(phenylsulfo...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	14.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...				Eur J Med Chem 46: 1189-97 (2011) Article DOI: 10.1016/j.ejmech.2011.01.038 BindingDB Entry DOI: 10.7270/Q2HT2PMN
Chemical Diversity Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50340728 (2-{[5,7-Dimethyl-3-(phenylsulfonyl)pyrazolo[1,5-a]...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	22.2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor				Eur J Med Chem 46: 1189-97 (2011) Article DOI: 10.1016/j.ejmech.2011.01.038 BindingDB Entry DOI: 10.7270/Q2HT2PMN
Chemical Diversity Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50340727 (2,5,7-Triimethyl-phenylsulfonyl-pyrazolo[1,5-a]pyr...) Show SMILES Cc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	68.4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor				Eur J Med Chem 46: 1189-97 (2011) Article DOI: 10.1016/j.ejmech.2011.01.038 BindingDB Entry DOI: 10.7270/Q2HT2PMN
Chemical Diversity Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50340727 (2,5,7-Triimethyl-phenylsulfonyl-pyrazolo[1,5-a]pyr...) Show SMILES Cc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	88.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...				Eur J Med Chem 46: 1189-97 (2011) Article DOI: 10.1016/j.ejmech.2011.01.038 BindingDB Entry DOI: 10.7270/Q2HT2PMN
Chemical Diversity Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50340729 (5,7-Dimethyl-3-phenylsulfonyl-pyrazolo[1,5-a]pyrim...) Show SMILES Cc1cc(C)n2ncc(c2n1)S(=O)(=O)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	237	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor				Eur J Med Chem 46: 1189-97 (2011) Article DOI: 10.1016/j.ejmech.2011.01.038 BindingDB Entry DOI: 10.7270/Q2HT2PMN
Chemical Diversity Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50340728 (2-{[5,7-Dimethyl-3-(phenylsulfonyl)pyrazolo[1,5-a]...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	283	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...				Eur J Med Chem 46: 1189-97 (2011) Article DOI: 10.1016/j.ejmech.2011.01.038 BindingDB Entry DOI: 10.7270/Q2HT2PMN
Chemical Diversity Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50340732 (CHEMBL1762572 \| N-[5,7-Dimethyl-3-(phenylsulfonyl)...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	489	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...				Eur J Med Chem 46: 1189-97 (2011) Article DOI: 10.1016/j.ejmech.2011.01.038 BindingDB Entry DOI: 10.7270/Q2HT2PMN
Chemical Diversity Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50340729 (5,7-Dimethyl-3-phenylsulfonyl-pyrazolo[1,5-a]pyrim...) Show SMILES Cc1cc(C)n2ncc(c2n1)S(=O)(=O)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	561	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...				Eur J Med Chem 46: 1189-97 (2011) Article DOI: 10.1016/j.ejmech.2011.01.038 BindingDB Entry DOI: 10.7270/Q2HT2PMN
Chemical Diversity Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50340733 (CHEMBL1762573 \| N'-[5,7-Dimethyl-3-(phenylsulfonyl...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	764	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...				Eur J Med Chem 46: 1189-97 (2011) Article DOI: 10.1016/j.ejmech.2011.01.038 BindingDB Entry DOI: 10.7270/Q2HT2PMN
Chemical Diversity Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM50340725 (CHEMBL1668584 \| N,5,7-trimethyl-3-(phenylsulfonyl)...) Show SMILES CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.04E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobi...				Eur J Med Chem 46: 1189-97 (2011) Article DOI: 10.1016/j.ejmech.2011.01.038 BindingDB Entry DOI: 10.7270/Q2HT2PMN
Chemical Diversity Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50340734 (5,7-Dimethyl-3-(phenylsulfonyl)-2-piperazin-1-ylpy...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.38E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...				Eur J Med Chem 46: 1189-97 (2011) Article DOI: 10.1016/j.ejmech.2011.01.038 BindingDB Entry DOI: 10.7270/Q2HT2PMN
Chemical Diversity Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50340735 ((2-{[5,7-Dimethyl-3-(phenylsulfonyl)pyrazolo[1,5-a...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...				Eur J Med Chem 46: 1189-97 (2011) Article DOI: 10.1016/j.ejmech.2011.01.038 BindingDB Entry DOI: 10.7270/Q2HT2PMN
Chemical Diversity Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50340736 (CHEMBL1762576 \| N'-[5,7-Dimethyl-3-(phenylsulfonyl...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...				Eur J Med Chem 46: 1189-97 (2011) Article DOI: 10.1016/j.ejmech.2011.01.038 BindingDB Entry DOI: 10.7270/Q2HT2PMN
Chemical Diversity Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50340737 (5,7-Dimethyl-2-(methylsulfinyl)-3-(phenylsulfonyl)...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2.96E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...				Eur J Med Chem 46: 1189-97 (2011) Article DOI: 10.1016/j.ejmech.2011.01.038 BindingDB Entry DOI: 10.7270/Q2HT2PMN
Chemical Diversity Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM50340725 (CHEMBL1668584 \| N,5,7-trimethyl-3-(phenylsulfonyl)...) Show SMILES CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.13E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT2B receptor				Eur J Med Chem 46: 1189-97 (2011) Article DOI: 10.1016/j.ejmech.2011.01.038 BindingDB Entry DOI: 10.7270/Q2HT2PMN
Chemical Diversity Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50340725 (CHEMBL1668584 \| N,5,7-trimethyl-3-(phenylsulfonyl)...) Show SMILES CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human ERG by patch clamp method				Eur J Med Chem 46: 1189-97 (2011) Article DOI: 10.1016/j.ejmech.2011.01.038 BindingDB Entry DOI: 10.7270/Q2HT2PMN
Chemical Diversity Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%