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PubMed code 21398124

Compile data set for download or QSAR
Found 62 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM20880
PNG
((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1
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n/an/a 4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340012
PNG
(6,8-dichloro-4-((5-(4-chlorophenethyl)-4-propyl-4H...)
Show SMILES CCCn1c(CCc2ccc(Cl)cc2)nnc1CN1C(=O)COc2c(Cl)cc(Cl)cc12
Show InChI InChI=1S/C22H21Cl3N4O2/c1-2-9-28-19(8-5-14-3-6-15(23)7-4-14)26-27-20(28)12-29-18-11-16(24)10-17(25)22(18)31-13-21(29)30/h3-4,6-7,10-11H,2,5,8-9,12-13H2,1H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340013
PNG
(6,8-dichloro-4-((5-(4-chlorophenethyl)-4-(3,3,3-tr...)
Show SMILES FC(F)(F)CCn1c(CCc2ccc(Cl)cc2)nnc1CN1C(=O)COc2c(Cl)cc(Cl)cc12
Show InChI InChI=1S/C22H18Cl3F3N4O2/c23-14-4-1-13(2-5-14)3-6-18-29-30-19(31(18)8-7-22(26,27)28)11-32-17-10-15(24)9-16(25)21(17)34-12-20(32)33/h1-2,4-5,9-10H,3,6-8,11-12H2
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340012
PNG
(6,8-dichloro-4-((5-(4-chlorophenethyl)-4-propyl-4H...)
Show SMILES CCCn1c(CCc2ccc(Cl)cc2)nnc1CN1C(=O)COc2c(Cl)cc(Cl)cc12
Show InChI InChI=1S/C22H21Cl3N4O2/c1-2-9-28-19(8-5-14-3-6-15(23)7-4-14)26-27-20(28)12-29-18-11-16(24)10-17(25)22(18)31-13-21(29)30/h3-4,6-7,10-11H,2,5,8-9,12-13H2,1H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]dapagliflozin from human SGLT2 expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340013
PNG
(6,8-dichloro-4-((5-(4-chlorophenethyl)-4-(3,3,3-tr...)
Show SMILES FC(F)(F)CCn1c(CCc2ccc(Cl)cc2)nnc1CN1C(=O)COc2c(Cl)cc(Cl)cc12
Show InChI InChI=1S/C22H18Cl3F3N4O2/c23-14-4-1-13(2-5-14)3-6-18-29-30-19(31(18)8-7-22(26,27)28)11-32-17-10-15(24)9-16(25)21(17)34-12-20(32)33/h1-2,4-5,9-10H,3,6-8,11-12H2
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340013
PNG
(6,8-dichloro-4-((5-(4-chlorophenethyl)-4-(3,3,3-tr...)
Show SMILES FC(F)(F)CCn1c(CCc2ccc(Cl)cc2)nnc1CN1C(=O)COc2c(Cl)cc(Cl)cc12
Show InChI InChI=1S/C22H18Cl3F3N4O2/c23-14-4-1-13(2-5-14)3-6-18-29-30-19(31(18)8-7-22(26,27)28)11-32-17-10-15(24)9-16(25)21(17)34-12-20(32)33/h1-2,4-5,9-10H,3,6-8,11-12H2
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Amgen Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]dapagliflozin from human SGLT2 expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM20880
PNG
((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340008
PNG
(6-chloro-4-((5-(4-chlorophenethyl)-4-(cyclopropylm...)
Show SMILES Clc1ccc(CCc2nnc(CN3C(=O)COc4ccc(Cl)cc34)n2CC2CC2)cc1
Show InChI InChI=1S/C23H22Cl2N4O2/c24-17-6-3-15(4-7-17)5-10-21-26-27-22(29(21)12-16-1-2-16)13-28-19-11-18(25)8-9-20(19)31-14-23(28)30/h3-4,6-9,11,16H,1-2,5,10,12-14H2
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340007
PNG
(4-((4-butyl-5-(4-chlorophenethyl)-4H-1,2,4-triazol...)
Show SMILES CCCCn1c(CCc2ccc(Cl)cc2)nnc1CN1C(=O)COc2ccc(Cl)cc12
Show InChI InChI=1S/C23H24Cl2N4O2/c1-2-3-12-28-21(11-6-16-4-7-17(24)8-5-16)26-27-22(28)14-29-19-13-18(25)9-10-20(19)31-15-23(29)30/h4-5,7-10,13H,2-3,6,11-12,14-15H2,1H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM20875
PNG
(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Show SMILES OC[C@H]1O[C@@H](Oc2cc(O)cc(O)c2C(=O)CCc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1
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n/an/a 36n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of SGLT2

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340029
PNG
(6-chloro-4-((5-(4-chlorophenethyl)-4-propyl-4H-1,2...)
Show SMILES CCCn1c(CCc2ccc(Cl)cc2)nnc1CN1C(=O)COc2ccc(Cl)cc12
Show InChI InChI=1S/C22H22Cl2N4O2/c1-2-11-27-20(10-5-15-3-6-16(23)7-4-15)25-26-21(27)13-28-18-12-17(24)8-9-19(18)30-14-22(28)29/h3-4,6-9,12H,2,5,10-11,13-14H2,1H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340012
PNG
(6,8-dichloro-4-((5-(4-chlorophenethyl)-4-propyl-4H...)
Show SMILES CCCn1c(CCc2ccc(Cl)cc2)nnc1CN1C(=O)COc2c(Cl)cc(Cl)cc12
Show InChI InChI=1S/C22H21Cl3N4O2/c1-2-9-28-19(8-5-14-3-6-15(23)7-4-14)26-27-20(28)12-29-18-11-16(24)10-17(25)22(18)31-13-21(29)30/h3-4,6-7,10-11H,2,5,8-9,12-13H2,1H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340010
PNG
(6-chloro-4-((5-(4-chlorophenethyl)-4-(3,3,3-triflu...)
Show SMILES FC(F)(F)CCn1c(CCc2ccc(Cl)cc2)nnc1CN1C(=O)COc2ccc(Cl)cc12
Show InChI InChI=1S/C22H19Cl2F3N4O2/c23-15-4-1-14(2-5-15)3-8-19-28-29-20(30(19)10-9-22(25,26)27)12-31-17-11-16(24)6-7-18(17)33-13-21(31)32/h1-2,4-7,11H,3,8-10,12-13H2
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340023
PNG
(4-((5-(4-chlorobenzylthio)-4-ethyl-4H-1,2,4-triazo...)
Show SMILES CCn1c(CN2C(=O)COc3ccc(C)cc23)nnc1SCc1ccc(Cl)cc1
Show InChI InChI=1S/C21H21ClN4O2S/c1-3-25-19(23-24-21(25)29-13-15-5-7-16(22)8-6-15)11-26-17-10-14(2)4-9-18(17)28-12-20(26)27/h4-10H,3,11-13H2,1-2H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340021
PNG
(6-bromo-4-((5-(4-chlorobenzylthio)-4-ethyl-4H-1,2,...)
Show SMILES CCn1c(CN2C(=O)COc3ccc(Br)cc23)nnc1SCc1ccc(Cl)cc1
Show InChI InChI=1S/C20H18BrClN4O2S/c1-2-25-18(23-24-20(25)29-12-13-3-6-15(22)7-4-13)10-26-16-9-14(21)5-8-17(16)28-11-19(26)27/h3-9H,2,10-12H2,1H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340022
PNG
(6-chloro-4-((5-(4-chlorobenzylthio)-4-ethyl-4H-1,2...)
Show SMILES CCn1c(CN2C(=O)COc3ccc(Cl)cc23)nnc1SCc1ccc(Cl)cc1
Show InChI InChI=1S/C20H18Cl2N4O2S/c1-2-25-18(23-24-20(25)29-12-13-3-5-14(21)6-4-13)10-26-16-9-15(22)7-8-17(16)28-11-19(26)27/h3-9H,2,10-12H2,1H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340026
PNG
(8-chloro-4-((5-(4-chlorobenzylthio)-4-ethyl-4H-1,2...)
Show SMILES CCn1c(CN2C(=O)COc3c(Cl)cccc23)nnc1SCc1ccc(Cl)cc1
Show InChI InChI=1S/C20H18Cl2N4O2S/c1-2-25-17(23-24-20(25)29-12-13-6-8-14(21)9-7-13)10-26-16-5-3-4-15(22)19(16)28-11-18(26)27/h3-9H,2,10-12H2,1H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340009
PNG
(6-chloro-4-((5-(4-chlorophenethyl)-4-isobutyl-4H-1...)
Show SMILES CC(C)Cn1c(CCc2ccc(Cl)cc2)nnc1CN1C(=O)COc2ccc(Cl)cc12
Show InChI InChI=1S/C23H24Cl2N4O2/c1-15(2)12-29-21(10-5-16-3-6-17(24)7-4-16)26-27-22(29)13-28-19-11-18(25)8-9-20(19)31-14-23(28)30/h3-4,6-9,11,15H,5,10,12-14H2,1-2H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340028
PNG
(4-((5-(4-chlorophenethyl)-4-propyl-4H-1,2,4-triazo...)
Show SMILES CCCn1c(CCc2ccc(Cl)cc2)nnc1CN1C(=O)COc2ccc(cc12)C(F)(F)F
Show InChI InChI=1S/C23H22ClF3N4O2/c1-2-11-30-20(10-5-15-3-7-17(24)8-4-15)28-29-21(30)13-31-18-12-16(23(25,26)27)6-9-19(18)33-14-22(31)32/h3-4,6-9,12H,2,5,10-11,13-14H2,1H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340019
PNG
(4-((5-(4-chlorobenzylthio)-4-ethyl-4H-1,2,4-triazo...)
Show SMILES CCn1c(CN2C(=O)COc3ccc(cc23)C(F)(F)F)nnc1SCc1ccc(Cl)cc1
Show InChI InChI=1S/C21H18ClF3N4O2S/c1-2-28-18(26-27-20(28)32-12-13-3-6-15(22)7-4-13)10-29-16-9-14(21(23,24)25)5-8-17(16)31-11-19(29)30/h3-9H,2,10-12H2,1H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM20875
PNG
(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Show SMILES OC[C@H]1O[C@@H](Oc2cc(O)cc(O)c2C(=O)CCc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1
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n/an/a 330n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of SGLT1

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM20880
PNG
((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1
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n/an/a 370n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340015
PNG
(4-((5-(4-chlorobenzylthio)-4-ethyl-4H-1,2,4-triazo...)
Show SMILES CCn1c(CN2C(=O)CSc3ccc(cc23)C(F)(F)F)nnc1SCc1ccc(Cl)cc1
Show InChI InChI=1S/C21H18ClF3N4OS2/c1-2-28-18(26-27-20(28)32-11-13-3-6-15(22)7-4-13)10-29-16-9-14(21(23,24)25)5-8-17(16)31-12-19(29)30/h3-9H,2,10-12H2,1H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/myo-inositol cotransporter 2


(Homo sapiens (Human))		BDBM20880
PNG
((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1
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n/an/a 380n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of SGLT6 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillation co...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Rattus norvegicus)		BDBM50340014
PNG
(4-((5-(4-chlorobenzylthio)-4-methyl-4H-1,2,4-triaz...)
Show SMILES Cn1c(CN2C(=O)CSc3ccc(cc23)C(F)(F)F)nnc1SCc1ccc(Cl)cc1
Show InChI InChI=1S/C20H16ClF3N4OS2/c1-27-17(25-26-19(27)31-10-12-2-5-14(21)6-3-12)9-28-15-8-13(20(22,23)24)4-7-16(15)30-11-18(28)29/h2-8H,9-11H2,1H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillatio...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340024
PNG
(7-chloro-4-((5-(4-chlorobenzylthio)-4-ethyl-4H-1,2...)
Show SMILES CCn1c(CN2C(=O)COc3cc(Cl)ccc23)nnc1SCc1ccc(Cl)cc1
Show InChI InChI=1S/C20H18Cl2N4O2S/c1-2-25-18(23-24-20(25)29-12-13-3-5-14(21)6-4-13)10-26-16-8-7-15(22)9-17(16)28-11-19(26)27/h3-9H,2,10-12H2,1H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340025
PNG
(7-bromo-4-((5-(4-chlorobenzylthio)-4-ethyl-4H-1,2,...)
Show SMILES CCn1c(CN2C(=O)COc3cc(Br)ccc23)nnc1SCc1ccc(Cl)cc1
Show InChI InChI=1S/C20H18BrClN4O2S/c1-2-25-18(23-24-20(25)29-12-13-3-6-15(22)7-4-13)10-26-16-8-5-14(21)9-17(16)28-11-19(26)27/h3-9H,2,10-12H2,1H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340027
PNG
(4-((5-(4-chlorophenethyl)-4-ethyl-4H-1,2,4-triazol...)
Show SMILES CCn1c(CCc2ccc(Cl)cc2)nnc1CN1C(=O)COc2ccc(cc12)C(F)(F)F
Show InChI InChI=1S/C22H20ClF3N4O2/c1-2-29-19(10-5-14-3-7-16(23)8-4-14)27-28-20(29)12-30-17-11-15(22(24,25)26)6-9-18(17)32-13-21(30)31/h3-4,6-9,11H,2,5,10,12-13H2,1H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340017
PNG
(4-((5-(4-chlorobenzylthio)-4-cyclopropyl-4H-1,2,4-...)
Show SMILES FC(F)(F)c1ccc2SCC(=O)N(Cc3nnc(SCc4ccc(Cl)cc4)n3C3CC3)c2c1
Show InChI InChI=1S/C22H18ClF3N4OS2/c23-15-4-1-13(2-5-15)11-33-21-28-27-19(30(21)16-6-7-16)10-29-17-9-14(22(24,25)26)3-8-18(17)32-12-20(29)31/h1-5,8-9,16H,6-7,10-12H2
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n/an/a 1.10E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Mus musculus (Mouse))		BDBM50340014
PNG
(4-((5-(4-chlorobenzylthio)-4-methyl-4H-1,2,4-triaz...)
Show SMILES Cn1c(CN2C(=O)CSc3ccc(cc23)C(F)(F)F)nnc1SCc1ccc(Cl)cc1
Show InChI InChI=1S/C20H16ClF3N4OS2/c1-27-17(25-26-19(27)31-10-12-2-5-14(21)6-3-12)9-28-15-8-13(20(22,23)24)4-7-16(15)30-11-18(28)29/h2-8H,9-11H2,1H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340016
PNG
(4-((5-(4-chlorobenzylthio)-4-isopropyl-4H-1,2,4-tr...)
Show SMILES CC(C)n1c(CN2C(=O)CSc3ccc(cc23)C(F)(F)F)nnc1SCc1ccc(Cl)cc1
Show InChI InChI=1S/C22H20ClF3N4OS2/c1-13(2)30-19(27-28-21(30)33-11-14-3-6-16(23)7-4-14)10-29-17-9-15(22(24,25)26)5-8-18(17)32-12-20(29)31/h3-9,13H,10-12H2,1-2H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340014
PNG
(4-((5-(4-chlorobenzylthio)-4-methyl-4H-1,2,4-triaz...)
Show SMILES Cn1c(CN2C(=O)CSc3ccc(cc23)C(F)(F)F)nnc1SCc1ccc(Cl)cc1
Show InChI InChI=1S/C20H16ClF3N4OS2/c1-27-17(25-26-19(27)31-10-12-2-5-14(21)6-3-12)9-28-15-8-13(20(22,23)24)4-7-16(15)30-11-18(28)29/h2-8H,9-11H2,1H3
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n/an/a 1.40E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340011
PNG
(6-chloro-4-((5-(4-chlorophenethyl)-4-cyclopropyl-4...)
Show SMILES Clc1ccc(CCc2nnc(CN3C(=O)COc4ccc(Cl)cc34)n2C2CC2)cc1
Show InChI InChI=1S/C22H20Cl2N4O2/c23-15-4-1-14(2-5-15)3-10-20-25-26-21(28(20)17-7-8-17)12-27-18-11-16(24)6-9-19(18)30-13-22(27)29/h1-2,4-6,9,11,17H,3,7-8,10,12-13H2
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n/an/a 1.58E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50340016
PNG
(4-((5-(4-chlorobenzylthio)-4-isopropyl-4H-1,2,4-tr...)
Show SMILES CC(C)n1c(CN2C(=O)CSc3ccc(cc23)C(F)(F)F)nnc1SCc1ccc(Cl)cc1
Show InChI InChI=1S/C22H20ClF3N4OS2/c1-13(2)30-19(27-28-21(30)33-11-14-3-6-16(23)7-4-14)10-29-17-9-15(22(24,25)26)5-8-18(17)32-12-20(29)31/h3-9,13H,10-12H2,1-2H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340020
PNG
(4-((5-(4-chlorobenzylthio)-4-ethyl-4H-1,2,4-triazo...)
Show SMILES CCn1c(CN2C(=O)COc3ccc(cc23)[N+]([O-])=O)nnc1SCc1ccc(Cl)cc1
Show InChI InChI=1S/C20H18ClN5O4S/c1-2-24-18(22-23-20(24)31-12-13-3-5-14(21)6-4-13)10-25-16-9-15(26(28)29)7-8-17(16)30-11-19(25)27/h3-9H,2,10-12H2,1H3
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n/an/a 2.10E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340018
PNG
(4-((5-(4-chlorobenzylthio)-4-phenyl-4H-1,2,4-triaz...)
Show SMILES FC(F)(F)c1ccc2SCC(=O)N(Cc3nnc(SCc4ccc(Cl)cc4)n3-c3ccccc3)c2c1
Show InChI InChI=1S/C25H18ClF3N4OS2/c26-18-9-6-16(7-10-18)14-36-24-31-30-22(33(24)19-4-2-1-3-5-19)13-32-20-12-17(25(27,28)29)8-11-21(20)35-15-23(32)34/h1-12H,13-15H2
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n/an/a 2.11E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50340025
PNG
(7-bromo-4-((5-(4-chlorobenzylthio)-4-ethyl-4H-1,2,...)
Show SMILES CCn1c(CN2C(=O)COc3cc(Br)ccc23)nnc1SCc1ccc(Cl)cc1
Show InChI InChI=1S/C20H18BrClN4O2S/c1-2-25-18(23-24-20(25)29-12-13-3-6-15(22)7-4-13)10-26-16-8-5-14(21)9-17(16)28-11-19(26)27/h3-9H,2,10-12H2,1H3
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n/an/a 2.53E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
SGLT1 protein


(Mus musculus (Mouse))		BDBM50340014
PNG
(4-((5-(4-chlorobenzylthio)-4-methyl-4H-1,2,4-triaz...)
Show SMILES Cn1c(CN2C(=O)CSc3ccc(cc23)C(F)(F)F)nnc1SCc1ccc(Cl)cc1
Show InChI InChI=1S/C20H16ClF3N4OS2/c1-27-17(25-26-19(27)31-10-12-2-5-14(21)6-3-12)9-28-15-8-13(20(22,23)24)4-7-16(15)30-11-18(28)29/h2-8H,9-11H2,1H3
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n/an/a 3.00E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse SGLT1 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50340024
PNG
(7-chloro-4-((5-(4-chlorobenzylthio)-4-ethyl-4H-1,2...)
Show SMILES CCn1c(CN2C(=O)COc3cc(Cl)ccc23)nnc1SCc1ccc(Cl)cc1
Show InChI InChI=1S/C20H18Cl2N4O2S/c1-2-25-18(23-24-20(25)29-12-13-3-5-14(21)6-4-13)10-26-16-8-7-15(22)9-17(16)28-11-19(26)27/h3-9H,2,10-12H2,1H3
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n/an/a 3.29E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50340018
PNG
(4-((5-(4-chlorobenzylthio)-4-phenyl-4H-1,2,4-triaz...)
Show SMILES FC(F)(F)c1ccc2SCC(=O)N(Cc3nnc(SCc4ccc(Cl)cc4)n3-c3ccccc3)c2c1
Show InChI InChI=1S/C25H18ClF3N4OS2/c26-18-9-6-16(7-10-18)14-36-24-31-30-22(33(24)19-4-2-1-3-5-19)13-32-20-12-17(25(27,28)29)8-11-21(20)35-15-23(32)34/h1-12H,13-15H2
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n/an/a 3.47E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50340017
PNG
(4-((5-(4-chlorobenzylthio)-4-cyclopropyl-4H-1,2,4-...)
Show SMILES FC(F)(F)c1ccc2SCC(=O)N(Cc3nnc(SCc4ccc(Cl)cc4)n3C3CC3)c2c1
Show InChI InChI=1S/C22H18ClF3N4OS2/c23-15-4-1-13(2-5-15)11-33-21-28-27-19(30(21)16-6-7-16)10-29-17-9-14(22(24,25)26)3-8-18(17)32-12-20(29)31/h1-5,8-9,16H,6-7,10-12H2
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n/an/a 3.75E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50340015
PNG
(4-((5-(4-chlorobenzylthio)-4-ethyl-4H-1,2,4-triazo...)
Show SMILES CCn1c(CN2C(=O)CSc3ccc(cc23)C(F)(F)F)nnc1SCc1ccc(Cl)cc1
Show InChI InChI=1S/C21H18ClF3N4OS2/c1-2-28-18(26-27-20(28)32-11-13-3-6-15(22)7-4-13)10-29-16-9-14(21(23,24)25)5-8-17(16)31-12-19(29)30/h3-9H,2,10-12H2,1H3
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n/an/a 4.75E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50340021
PNG
(6-bromo-4-((5-(4-chlorobenzylthio)-4-ethyl-4H-1,2,...)
Show SMILES CCn1c(CN2C(=O)COc3ccc(Br)cc23)nnc1SCc1ccc(Cl)cc1
Show InChI InChI=1S/C20H18BrClN4O2S/c1-2-25-18(23-24-20(25)29-12-13-3-6-15(22)7-4-13)10-26-16-9-14(21)5-8-17(16)28-11-19(26)27/h3-9H,2,10-12H2,1H3
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n/an/a 5.32E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50340020
PNG
(4-((5-(4-chlorobenzylthio)-4-ethyl-4H-1,2,4-triazo...)
Show SMILES CCn1c(CN2C(=O)COc3ccc(cc23)[N+]([O-])=O)nnc1SCc1ccc(Cl)cc1
Show InChI InChI=1S/C20H18ClN5O4S/c1-2-24-18(22-23-20(24)31-12-13-3-5-14(21)6-4-13)10-25-16-9-15(26(28)29)7-8-17(16)30-11-19(25)27/h3-9H,2,10-12H2,1H3
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n/an/a 5.61E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50340013
PNG
(6,8-dichloro-4-((5-(4-chlorophenethyl)-4-(3,3,3-tr...)
Show SMILES FC(F)(F)CCn1c(CCc2ccc(Cl)cc2)nnc1CN1C(=O)COc2c(Cl)cc(Cl)cc12
Show InChI InChI=1S/C22H18Cl3F3N4O2/c23-14-4-1-13(2-5-14)3-6-18-29-30-19(31(18)8-7-22(26,27)28)11-32-17-10-15(24)9-16(25)21(17)34-12-20(32)33/h1-2,4-5,9-10H,3,6-8,11-12H2
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n/an/a 6.29E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50340019
PNG
(4-((5-(4-chlorobenzylthio)-4-ethyl-4H-1,2,4-triazo...)
Show SMILES CCn1c(CN2C(=O)COc3ccc(cc23)C(F)(F)F)nnc1SCc1ccc(Cl)cc1
Show InChI InChI=1S/C21H18ClF3N4O2S/c1-2-28-18(26-27-20(28)32-12-13-3-6-15(22)7-4-13)10-29-16-9-14(21(23,24)25)5-8-17(16)31-11-19(29)30/h3-9H,2,10-12H2,1H3
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n/an/a 6.64E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50340009
PNG
(6-chloro-4-((5-(4-chlorophenethyl)-4-isobutyl-4H-1...)
Show SMILES CC(C)Cn1c(CCc2ccc(Cl)cc2)nnc1CN1C(=O)COc2ccc(Cl)cc12
Show InChI InChI=1S/C23H24Cl2N4O2/c1-15(2)12-29-21(10-5-16-3-6-17(24)7-4-16)26-27-22(29)13-28-19-11-18(25)8-9-20(19)31-14-23(28)30/h3-4,6-9,11,15H,5,10,12-14H2,1-2H3
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n/an/a 6.90E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50340014
PNG
(4-((5-(4-chlorobenzylthio)-4-methyl-4H-1,2,4-triaz...)
Show SMILES Cn1c(CN2C(=O)CSc3ccc(cc23)C(F)(F)F)nnc1SCc1ccc(Cl)cc1
Show InChI InChI=1S/C20H16ClF3N4OS2/c1-27-17(25-26-19(27)31-10-12-2-5-14(21)6-3-12)9-28-15-8-13(20(22,23)24)4-7-16(15)30-11-18(28)29/h2-8H,9-11H2,1H3
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n/an/a 7.00E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50340023
PNG
(4-((5-(4-chlorobenzylthio)-4-ethyl-4H-1,2,4-triazo...)
Show SMILES CCn1c(CN2C(=O)COc3ccc(C)cc23)nnc1SCc1ccc(Cl)cc1
Show InChI InChI=1S/C21H21ClN4O2S/c1-3-25-19(23-24-21(25)29-13-15-5-7-16(22)8-6-15)11-26-17-10-14(2)4-9-18(17)28-12-20(26)27/h4-10H,3,11-13H2,1-2H3
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n/an/a 7.13E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50340008
PNG
(6-chloro-4-((5-(4-chlorophenethyl)-4-(cyclopropylm...)
Show SMILES Clc1ccc(CCc2nnc(CN3C(=O)COc4ccc(Cl)cc34)n2CC2CC2)cc1
Show InChI InChI=1S/C23H22Cl2N4O2/c24-17-6-3-15(4-7-17)5-10-21-26-27-22(29(21)12-16-1-2-16)13-28-19-11-18(25)8-9-20(19)31-14-23(28)30/h3-4,6-9,11,16H,1-2,5,10,12-14H2
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n/an/a 7.28E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50340022
PNG
(6-chloro-4-((5-(4-chlorobenzylthio)-4-ethyl-4H-1,2...)
Show SMILES CCn1c(CN2C(=O)COc3ccc(Cl)cc23)nnc1SCc1ccc(Cl)cc1
Show InChI InChI=1S/C20H18Cl2N4O2S/c1-2-25-18(23-24-20(25)29-12-13-3-5-14(21)6-4-13)10-26-16-9-15(22)7-8-17(16)28-11-19(26)27/h3-9H,2,10-12H2,1H3
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n/an/a 7.34E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50340026
PNG
(8-chloro-4-((5-(4-chlorobenzylthio)-4-ethyl-4H-1,2...)
Show SMILES CCn1c(CN2C(=O)COc3c(Cl)cccc23)nnc1SCc1ccc(Cl)cc1
Show InChI InChI=1S/C20H18Cl2N4O2S/c1-2-25-17(23-24-20(25)29-12-13-6-8-14(21)9-7-13)10-26-16-5-3-4-15(22)19(16)28-11-18(26)27/h3-9H,2,10-12H2,1H3
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n/an/a 7.34E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Rattus norvegicus)		BDBM50340014
PNG
(4-((5-(4-chlorobenzylthio)-4-methyl-4H-1,2,4-triaz...)
Show SMILES Cn1c(CN2C(=O)CSc3ccc(cc23)C(F)(F)F)nnc1SCc1ccc(Cl)cc1
Show InChI InChI=1S/C20H16ClF3N4OS2/c1-27-17(25-26-19(27)31-10-12-2-5-14(21)6-3-12)9-28-15-8-13(20(22,23)24)4-7-16(15)30-11-18(28)29/h2-8H,9-11H2,1H3
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n/an/a 9.00E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat SGLT1 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillatio...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50340012
PNG
(6,8-dichloro-4-((5-(4-chlorophenethyl)-4-propyl-4H...)
Show SMILES CCCn1c(CCc2ccc(Cl)cc2)nnc1CN1C(=O)COc2c(Cl)cc(Cl)cc12
Show InChI InChI=1S/C22H21Cl3N4O2/c1-2-9-28-19(8-5-14-3-6-15(23)7-4-14)26-27-20(28)12-29-18-11-16(24)10-17(25)22(18)31-13-21(29)30/h3-4,6-7,10-11H,2,5,8-9,12-13H2,1H3
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n/an/a 9.14E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/myo-inositol cotransporter 2


(Homo sapiens (Human))		BDBM50340013
PNG
(6,8-dichloro-4-((5-(4-chlorophenethyl)-4-(3,3,3-tr...)
Show SMILES FC(F)(F)CCn1c(CCc2ccc(Cl)cc2)nnc1CN1C(=O)COc2c(Cl)cc(Cl)cc12
Show InChI InChI=1S/C22H18Cl3F3N4O2/c23-14-4-1-13(2-5-14)3-6-18-29-30-19(31(18)8-7-22(26,27)28)11-32-17-10-15(24)9-16(25)21(17)34-12-20(32)33/h1-2,4-5,9-10H,3,6-8,11-12H2
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n/an/a 9.20E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of SGLT6 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillation co...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50340028
PNG
(4-((5-(4-chlorophenethyl)-4-propyl-4H-1,2,4-triazo...)
Show SMILES CCCn1c(CCc2ccc(Cl)cc2)nnc1CN1C(=O)COc2ccc(cc12)C(F)(F)F
Show InChI InChI=1S/C23H22ClF3N4O2/c1-2-11-30-20(10-5-15-3-7-17(24)8-4-15)28-29-21(30)13-31-18-12-16(23(25,26)27)6-9-19(18)33-14-22(31)32/h3-4,6-9,12H,2,5,10-11,13-14H2,1H3
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n/an/a 9.88E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50340007
PNG
(4-((4-butyl-5-(4-chlorophenethyl)-4H-1,2,4-triazol...)
Show SMILES CCCCn1c(CCc2ccc(Cl)cc2)nnc1CN1C(=O)COc2ccc(Cl)cc12
Show InChI InChI=1S/C23H24Cl2N4O2/c1-2-3-12-28-21(11-6-16-4-7-17(24)8-5-16)26-27-22(28)14-29-19-13-18(25)9-10-20(19)31-15-23(29)30/h4-5,7-10,13H,2-3,6,11-12,14-15H2,1H3
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n/an/a 1.18E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50340029
PNG
(6-chloro-4-((5-(4-chlorophenethyl)-4-propyl-4H-1,2...)
Show SMILES CCCn1c(CCc2ccc(Cl)cc2)nnc1CN1C(=O)COc2ccc(Cl)cc12
Show InChI InChI=1S/C22H22Cl2N4O2/c1-2-11-27-20(10-5-15-3-6-16(23)7-4-15)25-26-21(27)13-28-18-12-17(24)8-9-19(18)30-14-22(28)29/h3-4,6-9,12H,2,5,10-11,13-14H2,1H3
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n/an/a 1.36E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50340010
PNG
(6-chloro-4-((5-(4-chlorophenethyl)-4-(3,3,3-triflu...)
Show SMILES FC(F)(F)CCn1c(CCc2ccc(Cl)cc2)nnc1CN1C(=O)COc2ccc(Cl)cc12
Show InChI InChI=1S/C22H19Cl2F3N4O2/c23-15-4-1-14(2-5-15)3-8-19-28-29-20(30(19)10-9-22(25,26)27)12-31-17-11-16(24)6-7-18(17)33-13-21(31)32/h1-2,4-7,11H,3,8-10,12-13H2
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n/an/a 1.38E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/myo-inositol cotransporter 2


(Homo sapiens (Human))		BDBM50340012
PNG
(6,8-dichloro-4-((5-(4-chlorophenethyl)-4-propyl-4H...)
Show SMILES CCCn1c(CCc2ccc(Cl)cc2)nnc1CN1C(=O)COc2c(Cl)cc(Cl)cc12
Show InChI InChI=1S/C22H21Cl3N4O2/c1-2-9-28-19(8-5-14-3-6-15(23)7-4-14)26-27-20(28)12-29-18-11-16(24)10-17(25)22(18)31-13-21(29)30/h3-4,6-7,10-11H,2,5,8-9,12-13H2,1H3
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n/an/a 1.44E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of SGLT6 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillation co...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50340011
PNG
(6-chloro-4-((5-(4-chlorophenethyl)-4-cyclopropyl-4...)
Show SMILES Clc1ccc(CCc2nnc(CN3C(=O)COc4ccc(Cl)cc34)n2C2CC2)cc1
Show InChI InChI=1S/C22H20Cl2N4O2/c23-15-4-1-14(2-5-15)3-10-20-25-26-21(28(20)17-7-8-17)12-27-18-11-16(24)6-9-19(18)30-13-22(27)29/h1-2,4-6,9,11,17H,3,7-8,10,12-13H2
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n/an/a 2.50E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50340027
PNG
(4-((5-(4-chlorophenethyl)-4-ethyl-4H-1,2,4-triazol...)
Show SMILES CCn1c(CCc2ccc(Cl)cc2)nnc1CN1C(=O)COc2ccc(cc12)C(F)(F)F
Show InChI InChI=1S/C22H20ClF3N4O2/c1-2-29-19(10-5-14-3-7-16(23)8-4-14)27-28-20(29)12-30-17-11-15(22(24,25)26)6-9-18(17)32-13-21(30)31/h3-4,6-9,11H,2,5,10,12-13H2,1H3
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n/an/a 4.60E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%