Affinity Data by PubMed id=21438612

PubMed code 21438612

Found 4 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Acetylcholinesterase (Homo sapiens (Human))	BDBM50364217 (CHEMBL1952048) Show SMILES CCCCN=C(CN=O)N(C)C \|w:4.3\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Human BioMolecular Research Institute Curated by ChEMBL					Assay Description Inhibition of recombinant AChE using acetylthiocholine as substrate after 1 hr by Ellman's method				J Med Chem 54: 3319-30 (2011) Article DOI: 10.1021/jm200054r BindingDB Entry DOI: 10.7270/Q25D8S9W
Human BioMolecular Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Cholinesterase (Homo sapiens (Human))	BDBM50364217 (CHEMBL1952048) Show SMILES CCCCN=C(CN=O)N(C)C \|w:4.3\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Human BioMolecular Research Institute Curated by ChEMBL					Assay Description Inhibition of BuChE using butyrylthiocholine as substrate after 20 mins by Ellman's method				J Med Chem 54: 3319-30 (2011) Article DOI: 10.1021/jm200054r BindingDB Entry DOI: 10.7270/Q25D8S9W
Human BioMolecular Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Rattus norvegicus (rat))	BDBM50011780 (2-[(E)-(hydroxyimino)methyl]-1-methylpyridinium ch...) Show SMILES C[n+]1ccccc1CN=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	2.10E+5	n/a	n/a	n/a	n/a	n/a
Human BioMolecular Research Institute Curated by ChEMBL					Assay Description Binding affinity to AChE in rat brain homogenate				J Med Chem 54: 3319-30 (2011) Article DOI: 10.1021/jm200054r BindingDB Entry DOI: 10.7270/Q25D8S9W
Human BioMolecular Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Rattus norvegicus (rat))	BDBM50020522 (1-(((4-carbamoylpyridinium-1-yl)methoxy)methyl)-2-...) Show SMILES NC(=O)c1cc[n+](COC[n+]2ccccc2CN=O)cc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	2.40E+4	n/a	n/a	n/a	n/a	n/a
Human BioMolecular Research Institute Curated by ChEMBL					Assay Description Binding affinity to AChE in rat brain homogenate				J Med Chem 54: 3319-30 (2011) Article DOI: 10.1021/jm200054r BindingDB Entry DOI: 10.7270/Q25D8S9W
Human BioMolecular Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%